MULTISPECIES: hypothetical protein [Enterobacteriaceae]
Protein Classification
phage holin family protein( domain architecture ID 6603)
phage holin family protein may function in the transport of murein hydrolases (endolysins) across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Phage_holin_2_1 super family | cl04868 | Bacteriophage P21 holin S; Phage_holin_2_1 is a family of small hydrophobic holin proteins ... |
4-57 | 1.38e-03 | ||
Bacteriophage P21 holin S; Phage_holin_2_1 is a family of small hydrophobic holin proteins with one or more transmembrane domains. Members of this family fall into the holin superfamily II, and Phage 21 S holin is the prototype for this superfamily. It has two transmembrane segments with both the N- and C-termini on the cytoplasmic side of the inner membrane in E. coli. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the build up of a holin oligomer which causes the lysis. The actual alignment was detected with superfamily member pfam16080: Pssm-ID: 446536 Cd Length: 56 Bit Score: 33.89 E-value: 1.38e-03
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| Name | Accession | Description | Interval | E-value | ||
| Phage_holin_2_3 | pfam16080 | Bacteriophage holin family HP1; Phage_holin_2_3 is a family of small hydrophobic phage ... |
4-57 | 1.38e-03 | ||
Bacteriophage holin family HP1; Phage_holin_2_3 is a family of small hydrophobic phage proteins called holins with one transmembrane domain. Holins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion 1,2]. Pssm-ID: 435124 Cd Length: 56 Bit Score: 33.89 E-value: 1.38e-03
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| Name | Accession | Description | Interval | E-value | ||
| Phage_holin_2_3 | pfam16080 | Bacteriophage holin family HP1; Phage_holin_2_3 is a family of small hydrophobic phage ... |
4-57 | 1.38e-03 | ||
Bacteriophage holin family HP1; Phage_holin_2_3 is a family of small hydrophobic phage proteins called holins with one transmembrane domain. Holins are produced by double-stranded DNA bacteriophages that use an endolysin-holin strategy to achieve lysis of their hosts. The endolysins are peptidoglycan-degrading enzymes that are usually accumulated in the cytosol until access to the cell wall substrate is provided by the holin membrane lesion 1,2]. Pssm-ID: 435124 Cd Length: 56 Bit Score: 33.89 E-value: 1.38e-03
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