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Conserved domains on  [gi|544826400|ref|WP_021242391|]
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hypothetical protein [Enterobacter roggenkampii]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CdiI_EcoliA0-like cd20693
inhibitor (or immunity protein) of the contact-dependent growth inhibition (CDI) system of ...
1-120 1.09e-44

inhibitor (or immunity protein) of the contact-dependent growth inhibition (CDI) system of Escherichia coli A0 34/86, and similar proteins; CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the inhibitor (CdiI, also called CdiI immunity protein) of the CdiA effector protein from Escherichia coli A0 34/86, and similar proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via its C-terminal domain (CdiA-CT). The CdiI immunity proteins are intracellular proteins that inactivate the toxin/effector protein to prevent auto-inhibition. They are specific for their cognate CdiA-CT and do not protect cells from the toxins of other CDI+ bacteria. Thus, CDI systems encode a complex network of toxin-immunity protein pairs that are deployed for intercellular competition. This E. coli CdiI binds its cognate toxin CdiA-CT domain with high affinity.


:

Pssm-ID: 412047  Cd Length: 124  Bit Score: 141.53  E-value: 1.09e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826400   1 MSLFEECKEALSADFSIIDKEE-ERVTTILEGYPFVS--GNISWSEISFRDFETSDELLCQSWLKNENVYVIADDANIPI 77
Cdd:cd20693    1 MTLFEECIEALGEDFRILSDEEsKEIYDKFENYFPFTswGRIDWSKINKKDIEIIDELLSLLNLKNEEVYIIWDDADIPV 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 544826400  78 FRTNLRLVLENIYDVAALSPKMFIFNE-NMILQPLFPTDaLRLG 120
Cdd:cd20693   81 IKTNLKLILENIDDVTAVSFDTWIFNPeNYVIEFYHEGE-ITVG 123
 
Name Accession Description Interval E-value
CdiI_EcoliA0-like cd20693
inhibitor (or immunity protein) of the contact-dependent growth inhibition (CDI) system of ...
1-120 1.09e-44

inhibitor (or immunity protein) of the contact-dependent growth inhibition (CDI) system of Escherichia coli A0 34/86, and similar proteins; CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the inhibitor (CdiI, also called CdiI immunity protein) of the CdiA effector protein from Escherichia coli A0 34/86, and similar proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via its C-terminal domain (CdiA-CT). The CdiI immunity proteins are intracellular proteins that inactivate the toxin/effector protein to prevent auto-inhibition. They are specific for their cognate CdiA-CT and do not protect cells from the toxins of other CDI+ bacteria. Thus, CDI systems encode a complex network of toxin-immunity protein pairs that are deployed for intercellular competition. This E. coli CdiI binds its cognate toxin CdiA-CT domain with high affinity.


Pssm-ID: 412047  Cd Length: 124  Bit Score: 141.53  E-value: 1.09e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826400   1 MSLFEECKEALSADFSIIDKEE-ERVTTILEGYPFVS--GNISWSEISFRDFETSDELLCQSWLKNENVYVIADDANIPI 77
Cdd:cd20693    1 MTLFEECIEALGEDFRILSDEEsKEIYDKFENYFPFTswGRIDWSKINKKDIEIIDELLSLLNLKNEEVYIIWDDADIPV 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 544826400  78 FRTNLRLVLENIYDVAALSPKMFIFNE-NMILQPLFPTDaLRLG 120
Cdd:cd20693   81 IKTNLKLILENIDDVTAVSFDTWIFNPeNYVIEFYHEGE-ITVG 123
 
Name Accession Description Interval E-value
CdiI_EcoliA0-like cd20693
inhibitor (or immunity protein) of the contact-dependent growth inhibition (CDI) system of ...
1-120 1.09e-44

inhibitor (or immunity protein) of the contact-dependent growth inhibition (CDI) system of Escherichia coli A0 34/86, and similar proteins; CDI toxins are expressed by gram-negative bacteria as part of a mechanism to inhibit the growth of neighboring cells. This model represents the inhibitor (CdiI, also called CdiI immunity protein) of the CdiA effector protein from Escherichia coli A0 34/86, and similar proteins. CdiA secretion is dependent on the outer membrane protein CdiB. Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via its C-terminal domain (CdiA-CT). The CdiI immunity proteins are intracellular proteins that inactivate the toxin/effector protein to prevent auto-inhibition. They are specific for their cognate CdiA-CT and do not protect cells from the toxins of other CDI+ bacteria. Thus, CDI systems encode a complex network of toxin-immunity protein pairs that are deployed for intercellular competition. This E. coli CdiI binds its cognate toxin CdiA-CT domain with high affinity.


Pssm-ID: 412047  Cd Length: 124  Bit Score: 141.53  E-value: 1.09e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826400   1 MSLFEECKEALSADFSIIDKEE-ERVTTILEGYPFVS--GNISWSEISFRDFETSDELLCQSWLKNENVYVIADDANIPI 77
Cdd:cd20693    1 MTLFEECIEALGEDFRILSDEEsKEIYDKFENYFPFTswGRIDWSKINKKDIEIIDELLSLLNLKNEEVYIIWDDADIPV 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 544826400  78 FRTNLRLVLENIYDVAALSPKMFIFNE-NMILQPLFPTDaLRLG 120
Cdd:cd20693   81 IKTNLKLILENIDDVTAVSFDTWIFNPeNYVIEFYHEGE-ITVG 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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