|
Name |
Accession |
Description |
Interval |
E-value |
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
166-430 |
8.60e-48 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 169.32 E-value: 8.60e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 166 CAWIAVRQVVRPFShftravdALDPAA--------STPMTEKGPLEVQRAAHAFNAMQARIQSYLRERAQILASISHDLQ 237
Cdd:PRK09467 169 GGWLFIRIQNRPLV-------ALEHAAlqvgkgeiPPPLREYGASEVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSHDLR 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 238 TPITRMKLRVEMAGEPE--LRDKLLNDLDNMSRLVREGIAYARSSEslEETSLKLELNAWINSIACDYQDIGKNVHFQAS 315
Cdd:PRK09467 242 TPLTRIRLATEMMSEEDgyLAESINKDIEECNAIIEQFIDYLRTGQ--EMPMEMADLNALLGEVIAAESGYEREIETALQ 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 316 ETRLPIVTRPQALRRVMTNLLDNALKFGeRAAIAIDDSSDSE-VIIHIMDDGPGIPEAELEAVLQPFYRVETSRNrdTGG 394
Cdd:PRK09467 320 PGPIEVPMNPIAIKRALANLVVNAARYG-NGWIKVSSGTEGKrAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSG 396
|
250 260 270
....*....|....*....|....*....|....*.
gi 544826497 395 TGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:PRK09467 397 TGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLP 432
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
217-433 |
1.56e-44 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 159.33 E-value: 1.56e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 217 RIQSYLRERAQILASISHDLQTPITRMKLRVEM-----AGEPELRDKLLN----DLDNMSRLVREGIAYARssesLEETS 287
Cdd:COG5002 157 ELERLEQMRREFVANVSHELRTPLTSIRGYLELlldgaADDPEERREYLEiileEAERLSRLVNDLLDLSR----LESGE 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 288 LKLE-----LNAWINSIACDYQDIGKN----VHFQASETRLPIVTRPQALRRVMTNLLDNALKFG-ERAAIAID-DSSDS 356
Cdd:COG5002 233 LKLEkepvdLAELLEEVVEELRPLAEEkgieLELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTpEGGTITVSlREEDD 312
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 544826497 357 EVIIHIMDDGPGIPEAELEAVLQPFYRVETSRNRDTGGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLPRRS 433
Cdd:COG5002 313 QVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLAR 389
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
121-432 |
5.48e-44 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 156.61 E-value: 5.48e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 121 AISHIQAHLTLRDGAPLTIDLIPRMPPVASWLPVVLILQLLVLAVCAWIAVRQVVRPFSHFTRAVDALDPAASTPMTEKG 200
Cdd:COG0642 6 LLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 201 PLEVQRAAHAFNAMQARIQSYLRERAQILASISHDLQTPITRMKLRVEMA---GEPELR---DKLLNDLDNMSRLVREGI 274
Cdd:COG0642 86 LLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLleeLDEEQReylETILRSADRLLRLINDLL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 275 AYARS-SESLEETSLKLELNAWINSIACDYQDI--GKNVHF--QASETRLPIVTRPQALRRVMTNLLDNALKFGER-AAI 348
Cdd:COG0642 166 DLSRLeAGKLELEPEPVDLAELLEEVVELFRPLaeEKGIELelDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEgGTV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 349 AID-DSSDSEVIIHIMDDGPGIPEAELEAVLQPFYRVETSRNrdTGGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAI 427
Cdd:COG0642 246 TVSvRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRR--GGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTV 323
|
....*
gi 544826497 428 TLPRR 432
Cdd:COG0642 324 TLPLA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
210-433 |
2.10e-42 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 149.67 E-value: 2.10e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 210 AFNAMQARIQSYLRERAQILASISHDLQTPITRMKLRVEMAGE-----PELRDKLLNDL----DNMSRLVREGIAYARss 280
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDeedlsPEERRELLEIIresaERLLRLIEDLLDLSR-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 281 esLEETSLKLE-----LNAWINSIACDYQDI----GKNVHFQASETRLPIVTRPQALRRVMTNLLDNALKFG-ERAAIAI 350
Cdd:COG2205 79 --LESGKLSLElepvdLAELLEEAVEELRPLaeekGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSpPGGTITI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 351 D-DSSDSEVIIHIMDDGPGIPEAELEAVLQPFYRVETSRNrdTGGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITL 429
Cdd:COG2205 157 SaRREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRG--EGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
....
gi 544826497 430 PRRS 433
Cdd:COG2205 235 PLAE 238
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
195-430 |
5.59e-37 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 140.45 E-value: 5.59e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 195 PMTEKGPLEVQRAAHAFNAMQARIQSYLRERAQILASISHDLQTPITRMKLRVEMA----GE-PELR---------DKLL 260
Cdd:PRK09470 213 PELETGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLATALLrrrqGEsKELErieteaqrlDSMI 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 261 NDLDNMSR------LVREGI-AYARSSESLEETSLKLELNawinsiacdyqdiGKNVHFQASETRLPIVTRPQALRRVMT 333
Cdd:PRK09470 293 NDLLVLSRnqqknhLERETFkANSLWSEVLEDAKFEAEQM-------------GKSLTVSAPPGPWPINGNPNALASALE 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 334 NLLDNALKFGE---RAAIAIDDSsdsEVIIHIMDDGPGIPEAELEAVLQPFYRVETSRNRDTGGTGLGLAIAAQLTAQLE 410
Cdd:PRK09470 360 NIVRNALRYSHtkiEVAFSVDKD---GLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHR 436
|
250 260
....*....|....*....|.
gi 544826497 411 GKLRlANRAG-GGLDVAITLP 430
Cdd:PRK09470 437 GWVK-AEDSPlGGLRLTIWLP 456
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
210-430 |
1.59e-31 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 124.72 E-value: 1.59e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 210 AFNAMQARIQSYLRERAQILASISHDLQTPITRMKLRVEMA---GEPElRDKLLNDLDNMSRLVREGIAYARssesLE-- 284
Cdd:PRK10604 197 AFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSdnlSAAE-SQALNRDIGQLEALIEELLTYAR----LDrp 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 285 ETSLKLE---LNAWINSIACDYQDI--GKNVHFQASETRLPIVTRPQALRRVMTNLLDNALKF-GERAAIAIDdSSDSEV 358
Cdd:PRK10604 272 QNELHLSepdLPAWLSTHLADIQAVtpEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYaHSRVRVSLL-LDGNQA 350
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544826497 359 IIHIMDDGPGIPEAELEAVLQPFYRVETSRNRDTGGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:PRK10604 351 CLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-430 |
2.98e-29 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 109.85 E-value: 2.98e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 328 LRRVMTNLLDNALKFGeraAIAIDDSSDSE---VIIHIMDDGPGIPEAELEAVLQPFYRVETSRnrDTGGTGLGLAIAAQ 404
Cdd:cd16950 1 LKRVLSNLVDNALRYG---GGWVEVSSDGEgnrTRIQVLDNGPGIAPEEVDELFQPFYRGDNAR--GTSGTGLGLAIVQR 75
|
90 100
....*....|....*....|....*.
gi 544826497 405 LTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:cd16950 76 ISDAHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-430 |
5.62e-29 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 109.34 E-value: 5.62e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 328 LRRVMTNLLDNALKFGeRAAIAIDDSSDS-EVIIHIMDDGPGIPEAELEAVLQPFYRVETSRNRDTGGTGLGLAIAAQLT 406
Cdd:cd16949 1 LARALENVLRNALRYS-PSKILLDISQDGdQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAI 79
|
90 100
....*....|....*....|....
gi 544826497 407 AQLEGKLRLANRAGGGLDVAITLP 430
Cdd:cd16949 80 EQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
325-432 |
5.19e-28 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 106.96 E-value: 5.19e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 325 PQALRRVMTNLLDNALKFG-ERAAIAID-DSSDSEVIIHIMDDGPGIPEAELEAVLQPFYRVEtSRNRDTGGTGLGLAIA 402
Cdd:smart00387 3 PDRLRQVLSNLLDNAIKYTpEGGRITVTlERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD-KRSRKIGGTGLGLSIV 81
|
90 100 110
....*....|....*....|....*....|
gi 544826497 403 AQLTAQLEGKLRLANRAGGGLDVAITLPRR 432
Cdd:smart00387 82 KKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
328-429 |
5.19e-26 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 101.14 E-value: 5.19e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 328 LRRVMTNLLDNALKFG-ERAAIAID-DSSDSEVIIHIMDDGPGIPEAELEAVLQPFYRVETSRNRdtGGTGLGLAIAAQL 405
Cdd:cd00075 1 LEQVLSNLLDNALKYSpPGGTIEISlRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 544826497 406 TAQLEGKLRLANRAGGGLDVAITL 429
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
226-431 |
2.44e-25 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 106.97 E-value: 2.44e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 226 AQILASISHDLQTPIT---------RMKLRVEMAGEPELRDKLL----NDLDNMSRLVREGIAYARSSE-SLEETSLkle 291
Cdd:COG5000 202 GELARRIAHEIKNPLTpiqlsaerlRRKLADKLEEDREDLERALdtiiRQVDRLKRIVDEFLDFARLPEpQLEPVDL--- 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 292 lNAWINSIACDYQD--IGKNVHFQAS--ETRLPIVTRPQALRRVMTNLLDNALK-FGERAAIAID-DSSDSEVIIHIMDD 365
Cdd:COG5000 279 -NELLREVLALYEPalKEKDIRLELDldPDLPEVLADRDQLEQVLINLLKNAIEaIEEGGEIEVStRREDGRVRIEVSDN 357
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544826497 366 GPGIPEAELEAVLQPFYrveTSRnrdTGGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLPR 431
Cdd:COG5000 358 GPGIPEEVLERIFEPFF---TTK---PKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
325-432 |
3.82e-25 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 98.98 E-value: 3.82e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 325 PQALRRVMTNLLDNALKF---GERAAIAIDDssDSEVIIHIMDDGPGIPEAELEAVLQPFYRVETsrnRDTGGTGLGLAI 401
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHaakAGEITVTLSE--GGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|.
gi 544826497 402 AAQLTAQLEGKLRLANRAGGGLDVAITLPRR 432
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
167-401 |
4.28e-24 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 104.01 E-value: 4.28e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 167 AWIAVRQVVRPFSHFTRAVDALDP---AASTPMTEKgPLEVQRAAHAFNAMQARIQSYLRERAQILASISHDLQTPITRM 243
Cdd:TIGR01386 181 GWWITRLGLEPLRRLSAVAARISPeslDQRLDPSRA-PAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNL 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 244 KLRVEMA-----GEPELRDKL---LNDLDNMSRLVREGIAYARSSESLEETSL-KLELNAWINSIACDYQDIgknvhfqA 314
Cdd:TIGR01386 260 LGQTQVAlsqprTGEEYREVLesnLEELERLSRMVSDMLFLARADNGQLALERvRLDLAAELAKVAEYFEPL-------A 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 315 SETRLPIVTR--------PQALRRVMTNLLDNALKF---GERAAIAIDDSSDsEVIIHIMDDGPGIPEAELEAVLQPFYR 383
Cdd:TIGR01386 333 EERGVRIRVEgeglvrgdPQMFRRAISNLLSNALRHtpdGGTITVRIERRSD-EVRVSVSNPGPGIPPEHLSRLFDRFYR 411
|
250
....*....|....*...
gi 544826497 384 VETSRNRDTGGTGLGLAI 401
Cdd:TIGR01386 412 VDPARSNSGEGTGLGLAI 429
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
107-431 |
3.36e-23 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 100.26 E-value: 3.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 107 LAAHYPLSFTAVPGAISHIQAHLTLRDGAPLTIDLIPRMPPVASWLPVVLILQLLVLAVCAWIAVRQVVRPFSHFTRAVD 186
Cdd:COG4191 22 LALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAAL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 187 ALDPAASTPMTEKGPLEVQRAAHAFNAMQAR-IQSylrER----AQILASISHDLQTPIT-------RMKLRVEMAGEPE 254
Cdd:COG4191 102 DAEENAELEELERDITELERAEEELRELQEQlVQS---EKlaalGELAAGIAHEINNPLAailgnaeLLRRRLEDEPDPE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 255 LRDKLLNDLDN----MSRLVREGIAYARSSESLEETslkLELNAWINSIA------CDYQDIgkNVHFQASETRLPIVTR 324
Cdd:COG4191 179 ELREALERILEgaerAAEIVRSLRAFSRRDEEEREP---VDLNELIDEALellrprLKARGI--EVELDLPPDLPPVLGD 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 325 PQALRRVMTNLLDN---ALKFGERAAIAID-DSSDSEVIIHIMDDGPGIPEAELEAVLQPFYrveTSRnRDTGGTGLGLA 400
Cdd:COG4191 254 PGQLEQVLLNLLINaidAMEEGEGGRITIStRREGDYVVISVRDNGPGIPPEVLERIFEPFF---TTK-PVGKGTGLGLS 329
|
330 340 350
....*....|....*....|....*....|.
gi 544826497 401 IAAQLTAQLEGKLRLANRAGGGLDVAITLPR 431
Cdd:COG4191 330 ISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
328-430 |
3.50e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 90.63 E-value: 3.50e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 328 LRRVMTNLLDNALKFGERAAIAI------DDSSDSEVIIHIMDDGPGIPEAELEAVLQPFYRVETSRNRDTGGTGLGLAI 401
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVTLrvsleeEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 544826497 402 AAQLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
193-430 |
5.76e-21 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 94.70 E-value: 5.76e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 193 STPMTEKGPLEVQRAAHAFNAMQARIQSYLRERAQILASISHDLQTPITRMKLRVE----------------MAGEPELR 256
Cdd:PRK10549 208 TTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELEaiqdgvrkftpesvasLQAEVGTL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 257 DKLLNDLDNMSRLVREGIAYARSSesleetslkLELNAWINSIACDYQDIgknvhFQASE----TRLP----IVTRPQAL 328
Cdd:PRK10549 288 TKLVDDLHQLSLSDEGALAYRKTP---------VDLVPLLEVAGGAFRER-----FASRGltlqLSLPdsatVFGDPDRL 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 329 RRVMTNLLDNALKF---GERAAIAIDdSSDSEVIIHIMDDGPGIPEAELEAVLQPFYRVETSRNRDTGGTGLGLAIAAQL 405
Cdd:PRK10549 354 MQLFNNLLENSLRYtdsGGSLHISAE-QRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNI 432
|
250 260
....*....|....*....|....*
gi 544826497 406 TAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:PRK10549 433 VEAHNGRIIAAHSPFGGVSITVELP 457
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
202-433 |
9.22e-21 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 94.47 E-value: 9.22e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 202 LEVQRAAHAFNAMQARIQSYLRERAQILASISHDLQTPITRMKL---RVEMAGEPELRDKLLNDLD-------NMSRLVR 271
Cdd:COG4251 259 LELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGfsqLLEEDYGDKLDEEGREYLErirdaaeRMQALID 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 272 EGIAYARSSeSLEETSLKLELNAWINSIACDYQDI--GKNVHFQASEtrLPIV-TRPQALRRVMTNLLDNALKF---GER 345
Cdd:COG4251 339 DLLAYSRVG-RQELEFEPVDLNELLEEVLEDLEPRieERGAEIEVGP--LPTVrGDPTLLRQVFQNLISNAIKYsrpGEP 415
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 346 AAIAID-DSSDSEVIIHIMDDGPGIPEAELEAVLQPFYRVETSRNRDtgGTGLGLAIAAQLTAQLEGKLRLANRAGGGLD 424
Cdd:COG4251 416 PRIEIGaEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYE--GTGIGLAIVKKIVERHGGRIWVESEPGEGAT 493
|
....*....
gi 544826497 425 VAITLPRRS 433
Cdd:COG4251 494 FYFTLPKAP 502
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
169-432 |
2.32e-19 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 90.22 E-value: 2.32e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 169 IAVRQVVRPFSHFTRAVDA---------LDPAAStpmtekgPLEVQRAAHAFNAMQARIQSYLRERAQILASISHDLQTP 239
Cdd:PRK09835 204 LAVHKGHAPIRSVSRQIQNitskdldvrLDPQTV-------PIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTP 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 240 ITRMKLRVEMA-----GEPELRDKL---LNDLDNMSRLVREGIAYARS-SESLEETSLKLELNAWINSIAcDY-----QD 305
Cdd:PRK09835 277 ITNLITQTEIAlsqsrSQKELEDVLysnLEELTRMAKMVSDMLFLAQAdNNQLIPEKKMLDLADEVGKVF-DFfeawaEE 355
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 306 IGKNVHFQASETRlpIVTRPQALRRVMTNLLDNALKF---GERAAIAIDDsSDSEVIIHIMDDGPGIPEAELEAVLQPFY 382
Cdd:PRK09835 356 RGVELRFVGDPCQ--VAGDPLMLRRAISNLLSNALRYtpaGEAITVRCQE-VDHQVQLVVENPGTPIAPEHLPRLFDRFY 432
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 544826497 383 RVETSRNRDTGGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVaITLPRR 432
Cdd:PRK09835 433 RVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFV-ISLPRL 481
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
205-430 |
5.61e-19 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 89.71 E-value: 5.61e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 205 QRAAHAFNAMQARIQSylrERAQI----LASISHDLQTPITRMKLRVEM-------AGEP------ELRD------KLLN 261
Cdd:PRK10490 643 ERLTLTASEEQARLAS---EREQLrnalLAALSHDLRTPLTVLFGQAEIltldlasEGSPharqasEIRQqvlnttRLVN 719
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 262 DLDNMSRLVREGIAYARSSESLEE---TSLK-LELNAWINSIACDYQDIGKNVHFQASetrlpivtrpqALRRVMTNLLD 337
Cdd:PRK10490 720 NLLDMARIQSGGFNLRKEWLTLEEvvgSALQmLEPGLSGHPINLSLPEPLTLIHVDGP-----------LFERVLINLLE 788
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 338 NALKF-GERAAIAIDDSSDSEVI-IHIMDDGPGIPEAELEAVLQPFYRVetsrNRDTG--GTGLGLAIAAQLTAQLEGKL 413
Cdd:PRK10490 789 NAVKYaGAQAEIGIDAHVEGERLqLDVWDNGPGIPPGQEQLIFDKFARG----NKESAipGVGLGLAICRAIVEVHGGTI 864
|
250
....*....|....*..
gi 544826497 414 RLANRAGGGLDVAITLP 430
Cdd:PRK10490 865 WAENRPEGGACFRVTLP 881
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-430 |
1.22e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 80.97 E-value: 1.22e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 325 PQALRRVMTNLLDNALKFGERAA-IAIDDSS-DSEVIIHIMDDGPGIPEAELEAVLQPFYRVETSRNRDTGGTGLGLAIA 402
Cdd:cd16946 2 RDRLQQLFVNLLENSLRYTDTGGkLRIRAAQtPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAIC 81
|
90 100
....*....|....*....|....*...
gi 544826497 403 AQLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:cd16946 82 HNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
176-428 |
4.15e-18 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 85.86 E-value: 4.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 176 RPFSHFTRAVDALDPAASTPMTEKG-PLEVQRAAHAFNAMQARIQSYL-RERaQILASISHDLQTPITRMKLRVEMA--- 250
Cdd:PRK10337 187 APLKKLALALRMRDPDSETPLNATGvPSEVRPLVEALNQLFARTHAMMvRER-RFTSDAAHELRSPLAALKVQTEVAqls 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 251 -GEPELRDKLLNDL----DNMSRLVREGIAYAR-SSESLEETSLKLELNAWINSIACDY----QDIGKNVHFQASETrlP 320
Cdd:PRK10337 266 dDDPQARKKALLQLhagiDRATRLVDQLLTLSRlDSLDNLQDVAEIPLEDLLQSAVMDIyhtaQQAGIDVRLTLNAH--P 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 321 IVTRPQAL--RRVMTNLLDNALKFGERAAIAidDSSDSEVIIHIMDDGPGIPEAELEAVLQPFYRvetSRNRDTGGTGLG 398
Cdd:PRK10337 344 VIRTGQPLllSLLVRNLLDNAIRYSPQGSVV--DVTLNARNFTVRDNGPGVTPEALARIGERFYR---PPGQEATGSGLG 418
|
250 260 270
....*....|....*....|....*....|.
gi 544826497 399 LAIAAQLtAQLEG-KLRLANRAGGGLDVAIT 428
Cdd:PRK10337 419 LSIVRRI-AKLHGmNVSFGNAPEGGFEAKVS 448
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-429 |
8.30e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 78.60 E-value: 8.30e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 328 LRRVMTNLLDNALKF-GERAAIAIDDSSDSEVIIHIMDDGPGIPEAELEAVLQPFYRvetSRNRDTGGTGLGLAIAAQLT 406
Cdd:cd16940 14 LFLLLRNLVDNAVRYsPQGSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYR---SDGQNYGGSGLGLSIVKRIV 90
|
90 100
....*....|....*....|...
gi 544826497 407 AQLEGKLRLANRAGGGLDVAITL 429
Cdd:cd16940 91 ELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-431 |
6.62e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 75.93 E-value: 6.62e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 328 LRRVMTNLLDNALKFGER-AAIAIDDSSDSEVIIhIMDDGPGIPEAELEAVLQPFYRVETSRNRDTGGTGLGLAIAAQLT 406
Cdd:cd16939 1 MARALDNLLRNALRYAHRtVRIALLVSGGRLTLI-VEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVA 79
|
90 100
....*....|....*....|....*
gi 544826497 407 AQLEGKLRLANRAGGGLDVAITLPR 431
Cdd:cd16939 80 LWHGGHVECDDSELGGACFRLTWPR 104
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
168-432 |
4.07e-16 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 79.24 E-value: 4.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 168 WIAVRQVVRPFSHF-----TRAVDALDPAASTPMTEkgplEVQRAAHAFNAMQARIQSYLRERAQILASISHDLQTPITR 242
Cdd:PRK10755 79 FQAVRWITRPLAELqkeleARTADNLTPIAIHSSTL----EIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAG 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 243 MKLRVEM---AGEPELrDKLLNDLDNMSRLVREGIAYARSSESLeeTSLKLELNAWINSIACDYQD------IGKNVHFQ 313
Cdd:PRK10755 155 IRLHLELlekQHHIDV-APLIARLDQMMHTVEQLLQLARAGQSF--SSGHYQTVKLLEDVILPSQDelsemlEQRQQTLL 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 314 ASETRLPIVTRPQA--LRRVMTNLLDNALKFG-ERAAIAID-DSSDSEVIIHIMDDGPGIPEAELEAVLQPFYRVETSrn 389
Cdd:PRK10755 232 LPESAADITVQGDAtlLRLLLRNLVENAHRYSpEGSTITIKlSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDSR-- 309
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 544826497 390 rdTGGTGLGLAIAAQLTAQLEGKLRLANRA-GGGLDVAITLPRR 432
Cdd:PRK10755 310 --YGGIGLGLSIVSRITQLHHGQFFLQNRQeRSGTRAWVWLPKA 351
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
168-430 |
5.17e-16 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 80.46 E-value: 5.17e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 168 WIAVRQVVRPFSHFTRAVDALDPAA-STPMTEKGPLEVQRAAHAFNAMQARIQSYLR-------ERAQILA--------- 230
Cdd:PRK15347 315 LLLRRYLAKPLWRFVDIINKTGPAAlEPRLPENRLDELGSIAKAYNQLLDTLNEQYDtlenkvaERTQALAeakqraeqa 394
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 231 ---------SISHDLQTPITRMKLRVEM-------AGEPELRD----------KLLNDLDNMSRlvregIAYARSSESLE 284
Cdd:PRK15347 395 nkrksehltTISHEIRTPLNGVLGALELlqntpltAEQMDLADtarqctlsllAIINNLLDFSR-----IESGQMTLSLE 469
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 285 ETSLKLELNAWINSIACDYQDIGKNVH-FQASETRLPIVTRPQALRRVMTNLLDNALKFGERAAIAID-DSSDSEVIIHI 362
Cdd:PRK15347 470 ETALLPLLDQAMLTIQGPAQSKSLTLRtFVGAHVPLYLHLDSLRLRQILVNLLGNAVKFTETGGIRLRvKRHEQQLCFTV 549
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544826497 363 MDDGPGIPEAELEAVLQPFYRVETSRnrdtGGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:PRK15347 550 EDTGCGIDIQQQQQIFTPFYQADTHS----QGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
309-418 |
1.72e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 72.55 E-value: 1.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 309 NVHFQASETRLPIVTRPQALRRVMTNLLDNALKFGERAAIAIDDSSDSE--VIIHIMDDGPGIPEAELEAVLQPFYRVET 386
Cdd:cd16947 2 QVEINIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEkhVYIDIWDKGKGISETEKDHVFERLYTLED 81
|
90 100 110
....*....|....*....|....*....|..
gi 544826497 387 SRNRDTGGTGLGLAIAAQLTAQLEGKLRLANR 418
Cdd:cd16947 82 SRNSAKQGNGLGLTITKRLAESMGGSIYVNSK 113
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
303-429 |
1.76e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 72.66 E-value: 1.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 303 YQDIGKNVHFQAS-ETRLPIvtRPQALRRVMTNLLDNALKFG-ERAAIAIDDSSDSEVIIhIMDDGPGIPEAELEAVLQP 380
Cdd:cd16954 14 YQRKGVSISLDISpELRFPG--ERNDLMELLGNLLDNACKWClEFVEVTARQTDGGLHLI-VDDDGPGVPESQRSKIFQR 90
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 544826497 381 FYRVETSRNrdtgGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITL 429
Cdd:cd16954 91 GQRLDEQRP----GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
215-432 |
3.04e-15 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 78.02 E-value: 3.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 215 QARIQSYLRERAQ--ILASISHDLQTPITRM----KLRVEMAGEPELRDKL-------------LNDLDNMSRLVREGIA 275
Cdd:PRK11466 432 QARAEAEKASQAKsaFLAAMSHEIRTPLYGIlgtaQLLADNPALNAQRDDLraitdsgeslltiLNDILDYSAIEAGGKN 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 276 YARSSESLE-----ETSLKL---ELNAWINSIACDYQDIgknvhfqasetrLP--IVTRPQALRRVMTNLLDNALKFGER 345
Cdd:PRK11466 512 VSVSDEPFEprpllESTLQLmsgRVKGRPIRLATDIADD------------LPtaLMGDPRRIRQVITNLLSNALRFTDE 579
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 346 AAIAIDDSSDSEV-IIHIMDDGPGIPEAELEAVLQPFYRVETSRnrdtGGTGLGLAIAAQLTAQLEGKLRLANRAGGGLD 424
Cdd:PRK11466 580 GSIVLRSRTDGEQwLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSC 655
|
....*...
gi 544826497 425 VAITLPRR 432
Cdd:PRK11466 656 FCLRLPLR 663
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
307-433 |
7.10e-15 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 76.42 E-value: 7.10e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 307 GKNVHFQASETRLPIVTRPQALRRVMTNLLDNALKFG-ERAAIAIDDSSDSE-VIIHIMDDGPGIPEAELEAVLQPFY-- 382
Cdd:PRK11100 348 AKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSpEGGTITLSAEVDGEqVALSVEDQGPGIPDYALPRIFERFYsl 427
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 544826497 383 -RVETSRNrdtgGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLPRRS 433
Cdd:PRK11100 428 pRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
215-433 |
1.27e-14 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 75.77 E-value: 1.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 215 QARIQSYLR--ERAQIL----ASISHDLQTPITRMKLRVEM----AGEPELRDKL---LNDLDNMSRLVREGIAYARSSE 281
Cdd:PRK11360 374 RKRLQRRVArqERLAALgelvAGVAHEIRNPLTAIRGYVQIwrqqTSDPPSQEYLsvvLREVDRLNKVIDQLLEFSRPRE 453
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 282 SLEEtslKLELNAWINSIACDYQDIGK--NVHFQAS-ETRLP-IVTRPQALRRVMTNLLDNALK-FGERAAIAIDD--SS 354
Cdd:PRK11360 454 SQWQ---PVSLNALVEEVLQLFQTAGVqaRVDFETElDNELPpIWADPELLKQVLLNILINAVQaISARGKIRIRTwqYS 530
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544826497 355 DSEVIIHIMDDGPGIPEAELEAVLQPFYrveTSRNRdtgGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLPRRS 433
Cdd:PRK11360 531 DGQVAVSIEDNGCGIDPELLKKIFDPFF---TTKAK---GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINP 603
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
225-432 |
1.73e-14 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 75.05 E-value: 1.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 225 RAQILASISHDLQTPITRMKLRVEMAGEPEL----RDKLLN----DLDNMSRLVREGIAYARSsesleETSLKLELNAWI 296
Cdd:PRK11006 204 RRNFFANVSHELRTPLTVLQGYLEMMQDQPLegalREKALHtmreQTQRMEGLVKQLLTLSKI-----EAAPTIDLNEKV 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 297 NSIAC------DYQDIGKNVH---FQASEtRLPIVTRPQALRRVMTNLLDNALKFG-ERAAIAID-DSSDSEVIIHIMDD 365
Cdd:PRK11006 279 DVPMMlrvlerEAQTLSQGKHtitFEVDN-SLKVFGNEDQLRSAISNLVYNAVNHTpEGTHITVRwQRVPQGAEFSVEDN 357
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 544826497 366 GPGIPEAELEAVLQPFYRVETSRNRDTGGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLPRR 432
Cdd:PRK11006 358 GPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPER 424
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-426 |
1.84e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 69.03 E-value: 1.84e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 325 PQALRRVMTNLLDNALKFG-ERAAIAIDDSSDSE-VIIHIMDDGPGIPEAELEAVLQPFYRVETSRNRDTGgTGLGLAIA 402
Cdd:cd16945 2 PFLLRQAINNLLDNAIDFSpEGGLIALQLEADTEgIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKS-TGLGLAFV 80
|
90 100
....*....|....*....|....
gi 544826497 403 AQLTAQLEGKLRLANRAGGGLDVA 426
Cdd:cd16945 81 QEVAQLHGGRITLRNRPDGVLAFL 104
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
227-430 |
2.93e-14 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 74.38 E-value: 2.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 227 QILASISHDLQTPITRMK-----LRVEMAGEPELRDKLLNDLDNMSRLVREGIAYAR-SSESLEETSLKLELNAWINSIA 300
Cdd:COG5805 289 QLAAGIAHEIRNPLTSIKgflqlLQPGIEDKEEYFDIMLSELDRIESIISEFLALAKpQAVNKEKENINELIQDVVTLLE 368
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 301 CDYQDIGKNVHFQASETRLPIVTRPQALRRVMTNLLDNALKF---GERAAIAIDDSsDSEVIIHIMDDGPGIPEAELEAV 377
Cdd:COG5805 369 TEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAmpnGGTITIHTEEE-DNSVIIRVIDEGIGIPEERLKKL 447
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 544826497 378 LQPFYRVETSrnrdtgGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:COG5805 448 GEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
202-430 |
5.03e-14 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 74.39 E-value: 5.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 202 LEVQRAaHAFNAMQARiqsylrerAQILASISHDLQTPITRMKLRVEMAGEpelrdkllNDLDNMSRLVREGIAYARSS- 280
Cdd:PRK09959 698 LEVERN-KAINATVAK--------SQFLATMSHEIRTPISSIMGFLELLSG--------SGLSKEQRVEAISLAYATGQs 760
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 281 -----------ESLEETSLKLElNAWINsIACDYQDI---------GKNVHFQASET---RLPIVTRPQALRRVMTNLLD 337
Cdd:PRK09959 761 llgligeildvDKIESGNYQLQ-PQWVD-IPTLVQNTchsfgaiaaSKSIALSCSSTfpdHYLVKIDPQAFKQVLSNLLS 838
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 338 NALKFGERAAIAIDDS----SDSEVIIH--IMDDGPGIPEAELEAVLQPFyrVETSRNRDTGGTGLGLAIAAQLTAQLEG 411
Cdd:PRK09959 839 NALKFTTEGAVKITTSlghiDDNHAVIKmtIMDSGSGLSQEEQQQLFKRY--SQTSAGRQQTGSGLGLMICKELIKNMQG 916
|
250
....*....|....*....
gi 544826497 412 KLRLANRAGGGLDVAITLP 430
Cdd:PRK09959 917 DLSLESHPGIGTTFTITIP 935
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-431 |
6.32e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 67.45 E-value: 6.32e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 325 PQALRRVMTNLLDNALK-FGERAAIAIDDS-SDSEVIIHIMDDGPGIPEAELEAVLQPFYrveTSRNRDTGgTGLGLAIA 402
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQaMEGRGRITIRTWaHVDQVLIEVEDTGSGIDPEILGRIFDPFF---TTKPVGEG-TGLGLSLS 76
|
90 100
....*....|....*....|....*....
gi 544826497 403 AQLTAQLEGKLRLANRAGGGLDVAITLPR 431
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
168-431 |
7.74e-14 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 73.13 E-value: 7.74e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 168 WIAVRQVVRPFSHFTRAVDALDPAASTPMTEKGPLEVQRAAHAFNAM-QARIQSYLRERAQiLASISHDLQTPI-----T 241
Cdd:PRK10815 209 WLAAWWSLRPIEALAKQVRELEEGEREQLDPNPPRELTSLVRNLNRLlKNERERYTKYRTT-LTDLTHSLKTPLavlqsT 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 242 RMKLR------VEMAgEPELrdkllndLDNMSRLVREgIAY--ARSSESLEETSLKLELN---AWINSIACD----YQDI 306
Cdd:PRK10815 288 LRSLRsgkqmsVEQA-EPIM-------LEQISRISQQ-IGYylHRASMRSEHNLLSRELHsvaPLLDNLTSAlnkvYQRK 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 307 GKNVHFQASeTRLPIVTRPQALRRVMTNLLDNA----LKFGERAAIaiddSSDSEVIIHIMDDGPGIPEAELEAVLQPFY 382
Cdd:PRK10815 359 GVNITLDIS-PEITFVGEKNDFMEVMGNVLDNAckycLEFVEISAR----QTDEHLHIVVEDDGPGIPESKRELIFDRGQ 433
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 544826497 383 RVETSRNrdtgGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLPR 431
Cdd:PRK10815 434 RADTLRP----GQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIFGR 478
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-413 |
8.86e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 67.03 E-value: 8.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 328 LRRVMTNLLDNALKFG-ERAAIAID-DSSDSEVIIHIMDDGPGIPEAELEAVLQPFYRVETSRNrdTGGTGLGLAIAAQL 405
Cdd:cd16923 1 LQRVFSNLLSNAIKYSpENTRIYITsFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAI 78
|
....*...
gi 544826497 406 TAQLEGKL 413
Cdd:cd16923 79 IELHGGSA 86
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
325-430 |
1.89e-13 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 66.36 E-value: 1.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 325 PQALRRVMTNLLDNALKF---GERAAIAIDDSSDSEVIIHIMDDGPGIPEAELEAVLQPFYRVETSRNRDTGGTGLGLAI 401
Cdd:cd16925 2 AEKYERVVLNLLSNAFKFtpdGGRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSI 81
|
90 100
....*....|....*....|....*....
gi 544826497 402 AAQLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:cd16925 82 VKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
213-401 |
2.18e-13 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 71.14 E-value: 2.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 213 AMQARIQSylreRAQILASISHDLQTPITRMKLRVE----------MAGEPELRDKLL----NDLDNMSRLVREGIAYAR 278
Cdd:PRK09303 143 TLLEQLKF----KDRVLAMLAHDLRTPLTAASLALEtlelgqidedTELKPALIEQLQdqarRQLEEIERLITDLLEVGR 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 279 SS-ESLEETSLKLELNAWINSIACDYQDI--GKNVHFQAS-ETRLPIV-TRPQALRRVMTNLLDNALKF---GERAAIAI 350
Cdd:PRK09303 219 TRwEALRFNPQKLDLGSLCQEVILELEKRwlAKSLEIQTDiPSDLPSVyADQERIRQVLLNLLDNAIKYtpeGGTITLSM 298
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 544826497 351 DDSSDSEVIIHIMDDGPGIPEAELEAVLQPFYRVetSRNRDTGGTGLGLAI 401
Cdd:PRK09303 299 LHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRL--PRDEGTEGYGIGLSV 347
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-430 |
4.11e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 65.04 E-value: 4.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 328 LRRVMTNLLDNALKF-GERAAIAIDDSSD---SEVIIHIMDDGPGIPEAELEAVLQPFYRVETsrNRDTGGTGLGLAIAA 403
Cdd:cd16921 1 LGQVLTNLLGNAIKFrRPRRPPRIEVGAEdvgEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 544826497 404 QLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
227-430 |
4.51e-13 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 70.77 E-value: 4.51e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 227 QILASISHDLQTPITRMK----LRVEMAGEPELR--DKLLNDLDNMSRLVREGIAYAR-SSESLEETSLklelNAWINSI 299
Cdd:COG5809 272 ELAAGIAHEIRNPLTSLKgfiqLLKDTIDEEQKTylDIMLSELDRIESIISEFLVLAKpQAIKYEPKDL----NTLIEEV 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 300 A--CDYQDIGKNVHFQ-ASETRLP-IVTRPQALRRVMTNLLDNALKF---GERAAIAIDDSSDSEVIIHIMDDGPGIPEA 372
Cdd:COG5809 348 IplLQPQALLKNVQIElELEDDIPdILGDENQLKQVFINLLKNAIEAmpeGGNITIETKAEDDDKVVISVTDEGCGIPEE 427
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 544826497 373 ELEAVLQPFYrvetsrNRDTGGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:COG5809 428 RLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-422 |
7.23e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 64.40 E-value: 7.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 328 LRRVMTNLLDNAL-KFGERAAIAID---DSSDSEVIIHIMDDGPGIPEAELEAVLQPFYRVetsrnRDTG-GTGLGLAIA 402
Cdd:cd16976 1 IQQVLMNLLQNALdAMGKVENPRIRiaaRRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTT-----KPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|
gi 544826497 403 AQLTAQLEGKLRLANRAGGG 422
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAG 95
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
214-433 |
1.21e-12 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 68.72 E-value: 1.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 214 MQARIQSYLRERAQ------ILASISHDLQTPIT-------RMKLRVEMAGEPELRDKLLNDLDNMSRLVREGIAYARSS 280
Cdd:COG3852 118 ERKRLERELRRAEKlaavgeLAAGLAHEIRNPLTgirgaaqLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPR 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 281 ESLEETslkLELNAWIN---SIACdyQDIGKNVHFQAS-ETRLPIVT-RPQALRRVMTNLLDNAL----KFGE---RAAI 348
Cdd:COG3852 198 PPEREP---VNLHEVLErvlELLR--AEAPKNIRIVRDyDPSLPEVLgDPDQLIQVLLNLVRNAAeampEGGTitiRTRV 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 349 AIDDSSDSE-----VIIHIMDDGPGIPEAELEAVLQPFYrveTSRnrdTGGTGLGLAIAAQLTAQLEGKLRLANRAGGGL 423
Cdd:COG3852 273 ERQVTLGGLrprlyVRIEVIDNGPGIPEEILDRIFEPFF---TTK---EKGTGLGLAIVQKIVEQHGGTIEVESEPGKGT 346
|
250
....*....|
gi 544826497 424 DVAITLPRRS 433
Cdd:COG3852 347 TFRIYLPLEQ 356
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
308-433 |
1.98e-12 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 68.34 E-value: 1.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 308 KNVHFQAS-ETRLP-IVTRPQALRRVMTNLLDNALkfgeRAAIAIDDS----------SDSEVIIHIMDDGPGIPEAELE 375
Cdd:COG3290 260 RGIDLTIDiDSDLPdLPLSDTDLVTILGNLLDNAI----EAVEKLPEEerrvelsirdDGDELVIEVEDSGPGIPEELLE 335
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 544826497 376 AVLQPfyRVETsrnRDTGGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLPRRS 433
Cdd:COG3290 336 KIFER--GFST---KLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEG 388
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-432 |
3.69e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 62.60 E-value: 3.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 328 LRRVMTNLLDNALKFG-ERAAIAIDDSSD-SEVIIHIMDDGPGIPEAELEAVLQPFYRVETSRNRDTGGTGLGLAIAAQL 405
Cdd:cd16952 1 LRSAFSNLVSNAVKYTpPSDTITVRWSQEeSGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*..
gi 544826497 406 TAQLEGKLRLANRAGGGLDVAITLPRR 432
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFPSS 107
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
223-411 |
1.15e-11 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 66.89 E-value: 1.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 223 RERAQILASISHDLQTPI------TRMKLRVEMAGEPELRDK-----------LLNDLDNMSRLVREGIAYARSSESLEE 285
Cdd:PRK11091 281 RDKTTFISTISHELRTPLngivglSRILLDTELTAEQRKYLKtihvsaitlgnIFNDIIDMDKMERRKLQLDNQPIDFTD 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 286 TSLKLElnawiNSIACDYQDIGKNVHFqasETRLP----IVTRPQALRRVMTNLLDNALKFGERAAIAIDDSSDSEVIIH 361
Cdd:PRK11091 361 FLADLE-----NLSGLQAEQKGLRFDL---EPLLPlphkVITDGTRLRQILWNLISNAVKFTQQGGVTVRVRYEEGDMLT 432
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 544826497 362 --IMDDGPGIPEAELEAVLQPFYRVETSR-NRDTGGTGLGLAIAAQLtAQLEG 411
Cdd:PRK11091 433 feVEDSGIGIPEDELDKIFAMYYQVKDSHgGKPATGTGIGLAVSKRL-AQAMG 484
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-430 |
2.58e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 60.24 E-value: 2.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 327 ALRRVMTNLLDNALKFGERA-------AIAIDDSSDSEVIIHIMDDGPGIPEAELEAVLQPFYrveTSRNRdtgGTGLGL 399
Cdd:cd16944 4 QISQVLTNILKNAAEAIEGRpsdvgevRIRVEADQDGRIVLIVCDNGKGFPREMRHRATEPYV---TTRPK---GTGLGL 77
|
90 100 110
....*....|....*....|....*....|.
gi 544826497 400 AIAAQLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:cd16944 78 AIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
216-422 |
3.90e-11 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 65.26 E-value: 3.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 216 ARIQSylreraQILASISHDLQTPI------TRMKLRVEMAgePELRDKL-------------LNDLDNMSRL-----VR 271
Cdd:PRK11107 290 ARIKS------EFLANMSHELRTPLngvigfTRQTLKTPLT--PTQRDYLqtiersannllaiINDILDFSKLeagklVL 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 272 EGIAYA-RssESLEET-SL--------KLELnawinSIACDyQDIGKNVhfqasetrlpiVTRPQALRRVMTNLLDNALK 341
Cdd:PRK11107 362 ENIPFSlR--ETLDEVvTLlahsahekGLEL-----TLNID-PDVPDNV-----------IGDPLRLQQIITNLVGNAIK 422
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 342 FGERAAIAID----DSSDSEVIIHIM--DDGPGIPEAELEAVLQPFYRVETSRNRDTGGTGLGLAIAAQLTAQLEGKLRL 415
Cdd:PRK11107 423 FTESGNIDILvelrALSNTKVQLEVQirDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDISF 502
|
....*..
gi 544826497 416 ANRAGGG 422
Cdd:PRK11107 503 HSQPNRG 509
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
230-430 |
9.33e-11 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 63.27 E-value: 9.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 230 ASISHDLQTPITRMK-------LRVEMAGEP-ELRDKLLNDLDNMSRLVREGIAYARSSE-SLEETSLKLELNAWINSIA 300
Cdd:PRK10364 242 AGVAHEIRNPLSSIKglakyfaERAPAGGEAhQLAQVMAKEADRLNRVVSELLELVKPTHlALQAVDLNDLINHSLQLVS 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 301 CDYQDIGKNVHFQASETRLPIVTRPQALRRVMTNLLDNALK-FGERAAIAIDDS-SDSEVIIHIMDDGPGIPEAELEAVL 378
Cdd:PRK10364 322 QDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQaIGQHGVISVTASeSGAGVKISVTDSGKGIAADQLEAIF 401
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 544826497 379 QPFYrveTSRNRdtgGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:PRK10364 402 TPYF---TTKAE---GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
326-427 |
1.89e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 57.86 E-value: 1.89e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 326 QALRRVMTNLLDNALKFG-ERAAIAIDDSSDSEVI-IHIMDDGPGIPEAELEAVLQPFYRVETSRNRDtGGTGLGLAIAA 403
Cdd:cd16975 3 LLLSRALINIISNACQYApEGGTVSISIYDEEEYLyFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGLYIAK 81
|
90 100
....*....|....*....|....
gi 544826497 404 QLTAQLEGKLRLANRAGGGLDVAI 427
Cdd:cd16975 82 NLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
167-432 |
2.63e-10 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 61.96 E-value: 2.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 167 AWIAVRQVVRPFSHFTRAVDALDPAASTPMTEKGPLEVQRAAHAFNAMQARIQSYLRERAQILASIS------------- 233
Cdd:COG2972 174 SYLLSRSITRPIKRLKKAMKKVEKGDLVRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKeaelkalqaqinp 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 234 HDLQTPITRMKLRVEMAGEPELRDkLLNDLdnmSRLVREGIayarsSESLEETSLKLELNawinsIACDYQDIGK----- 308
Cdd:COG2972 254 HFLFNTLNSIRWLAELEDPEEAEE-MLEAL---SKLLRYSL-----SKGDELVTLEEELE-----LIKSYLEIQKlrfgd 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 309 --NVHFQASET--RLPIvtrpqaLRRVMTNLLDNALKFG-----ERAAIAID-DSSDSEVIIHIMDDGPGIPEAELEAVL 378
Cdd:COG2972 320 rlEVEIEIDEEllDLLI------PKLILQPLVENAIEHGiepkeGGGTIRISiRKEGDRLVITVEDNGVGMPEEKLEKLL 393
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 544826497 379 QPFyrvetsrNRDTGGTGLGLAIAAQLTAQLEGK---LRLANRAGGGLDVAITLPRR 432
Cdd:COG2972 394 EEL-------SSKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRIPLE 443
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
205-430 |
6.32e-10 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 61.53 E-value: 6.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 205 QRAAHAfnAMQARiQSylreRAQILASISHDLQTP----ITRMKLrVEMAGEPELRDKLLNDLDNMSRLVREGIAYARSS 280
Cdd:PRK10841 434 QEMAQA--AEQAS-QS----KSMFLATVSHELRTPlygiIGNLDL-LQTKELPKGVDRLVTAMNNSSSLLLKIISDILDF 505
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 281 ESLEETSLKLELNAW-----INSIACDYqdigknvhfqasetrLPIVTR--------------------PQALRRVMTNL 335
Cdd:PRK10841 506 SKIESEQLKIEPREFsprevINHITANY---------------LPLVVKkrlglycfiepdvpvalngdPMRLQQVISNL 570
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 336 LDNALKFGERAAIAIDDSSDSEVI-IHIMDDGPGIPEAELEAVLQPFYRVETSRNRDTGGTGLGLAIAAQLTAQLEGKLR 414
Cdd:PRK10841 571 LSNAIKFTDTGCIVLHVRVDGDYLsFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDIS 650
|
250
....*....|....*.
gi 544826497 415 LANRAGGGLDVAITLP 430
Cdd:PRK10841 651 VDSEPGMGSQFTIRIP 666
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-430 |
2.62e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 54.32 E-value: 2.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 328 LRRVMTNLLDNALK-----FGERAAIAIDDSS--DSEVIIHIMDDGPGIPEAELEAVLQPFYRVETSrnrdtgGTGLGLA 400
Cdd:cd16920 1 IQQVLINLVRNGIEamsegGCERRELTIRTSPadDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 544826497 401 IAAQLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-430 |
3.52e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 54.21 E-value: 3.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 328 LRRVMTNLLDNALKF---GERAAIAIDDSsDSEVIIHIMDDGPGIPEAELEAVLQPFYRVETSRNrDTGGTGLGLAIAAQ 404
Cdd:cd16948 6 LSFIIGQIVSNALKYskqGGKIEIYSETN-EQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRN-FQESTGMGLYLVKK 83
|
90 100
....*....|....*....|....*.
gi 544826497 405 LTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:cd16948 84 LCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
203-433 |
1.25e-08 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 55.39 E-value: 1.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 203 EVQRAAHAFNAMQARIQSY-LRERAQILASIsHD--LQTpITRMKLRVEMAGE--PELRDKLLNDLDNMSRLVREGIAYA 277
Cdd:COG4585 31 RAERAAELERELAARAEEArEEERRRIAREL-HDgvGQS-LSAIKLQLEAARRllDADPEAAREELEEIRELAREALAEL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 278 RS------SESLEETSLKLELNAWINSIAcdyQDIGKNVHFQASET--RLPIVTRpQALRRVMTNLLDNALKFGERAAIA 349
Cdd:COG4585 109 RRlvrglrPPALDDLGLAAALEELAERLL---RAAGIRVELDVDGDpdRLPPEVE-LALYRIVQEALTNALKHAGATRVT 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 350 ID-DSSDSEVIIHIMDDGPGIPEAEleavlqpfyrvetsrnrdTGGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAIT 428
Cdd:COG4585 185 VTlEVDDGELTLTVRDDGVGFDPEA------------------APGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRAT 246
|
....*
gi 544826497 429 LPRRS 433
Cdd:COG4585 247 LPLAA 251
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-430 |
1.37e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 52.29 E-value: 1.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 334 NLLDNALKfgerAAIAIDDSS----------DSEVIIHIMDDGPGIPEAELEAVLQPFYRVETSRNRdtggtGLGLAIAA 403
Cdd:cd16915 7 NLIDNALD----ALAATGAPNkqvevflrdeGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----GIGLALVR 77
|
90 100
....*....|....*....|....*..
gi 544826497 404 QLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:cd16915 78 QSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-405 |
4.08e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 51.03 E-value: 4.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 328 LRRVMTNLLDNALKFGERAAIAIDDSSDSE---VIIHIMDDGPGIPEAELEAVLQPFYrVETSRNRDTG-GTGLGLAIAA 403
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDTGRITVSAMPTgkmVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
..
gi 544826497 404 QL 405
Cdd:cd16953 80 QI 81
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
325-413 |
6.12e-07 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 51.24 E-value: 6.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 325 PQALRRVMTNLLDNALK-FGERAA-IAIDDSSDSEVIIH-----------IMDDGPGIPeAELEAVLqpFYRVETSRNrd 391
Cdd:PRK11073 235 PDQIEQVLLNIVRNALQaLGPEGGtITLRTRTAFQLTLHgeryrlaaridIEDNGPGIP-PHLQDTL--FYPMVSGRE-- 309
|
90 100
....*....|....*....|..
gi 544826497 392 tGGTGLGLAIAAQLTAQLEGKL 413
Cdd:PRK11073 310 -GGTGLGLSIARNLIDQHSGKI 330
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-420 |
1.06e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 47.01 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 328 LRRVMTNLLDNALKF--GERAAIAIDDSSDSEVII-----------HIMDDGPGIPeAELEAVLqpFYRVETSRnrdTGG 394
Cdd:cd16918 1 LIQVFLNLVRNAAQAlaGSGGEIILRTRTQRQVTLghprhrlalrvSVIDNGPGIP-PDLQDTI--FYPMVSGR---ENG 74
|
90 100
....*....|....*....|....*.
gi 544826497 395 TGLGLAIAAQLTAQLEGKLRLANRAG 420
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPG 100
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
358-433 |
3.01e-06 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 49.68 E-value: 3.01e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544826497 358 VIIHIMDDGPGIPEAELEAVLQPFYrveTSRNrdtGGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLPRRS 433
Cdd:PRK13837 608 VLLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSS 677
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
225-430 |
3.73e-06 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 49.16 E-value: 3.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 225 RAQILASISHDLQTPITRM-----KLRV--EMAGEPELRDKLLNDLDNMSRLVregiayarsseslEETSL--KLELNAW 295
Cdd:PRK10618 450 RKAFLQNIGDELKQPLQSLaqlaaQLRQtsDEEQQQPELDQLAEQSDVLVRLV-------------DNIQLlnMLETQDW 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 296 -----INSIACDYQDIGK---------------NVHFQASETRlpIVTRPqALRRVMTNLLDNALKFGERAAIAI----D 351
Cdd:PRK10618 517 kpeqeLFSLQDLIDEVLPevlpaikrkglqlliHNHLKAEQLR--IGDRD-ALRKILLLLLNYAITTTAYGKITLevdqD 593
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544826497 352 DSSDSEVIIHIMDDGPGIPEAELEAVLQPFYRvETSRNRDTGGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:PRK10618 594 ESSPDRLTIRILDTGAGVSIKELDNLHFPFLN-QTQGDRYGKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLK 671
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
358-430 |
6.95e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 45.06 E-value: 6.95e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544826497 358 VIIHIMDDGPGIPEAELEAVLQPFYRVetsrnRDTG-GTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:cd16919 48 VCLEVSDTGSGMPAEVLRRAFEPFFTT-----KEVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
318-430 |
9.00e-06 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 47.98 E-value: 9.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 318 RLP-IVTRPQALRRVMTNLLDNAL-----KFGERAAIAIDDSSDSEVI-IHIMDDGPGIPEAELEAVLQPFYRVETSRNR 390
Cdd:TIGR02938 377 TLPaILGRELQLRSLFKALVDNAIeamniKGWKRRELSITTALNGDLIvVSILDSGPGIPQDLRYKVFEPFFTTKGGSRK 456
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 544826497 391 dtgGTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:TIGR02938 457 ---HIGMGLSVAQEIVADHGGIIDLDDDYSEGCRIIVEFR 493
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
224-278 |
1.19e-04 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 39.89 E-value: 1.19e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544826497 224 ERAQILASISHDLQTPITRMKLRVEMAGEP-------ELRDKLLNDLDNMSRLVREGIAYAR 278
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEkldeeqrEYLETILRSAERLLRLINDLLDLSR 62
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
227-416 |
1.35e-04 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 44.29 E-value: 1.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 227 QILASISHDLQTPITRM-------KLRVEMAGEPELR---DKLLNDLDNMSRLVREGIAYAR-SSESLEETSLKLELNAW 295
Cdd:COG4192 435 QTMTSLAHELNQPLNAMsmylfsaKKALEQENYAQLPtslDKIEGLIERMDKIIKSLRQFSRkSDTPLQPVDLRQVIEQA 514
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 296 INSIACDYQDIGKNVHFqasETRLPIVTRPQALRRVMTNLLDNALK-FGERAAIAID-DSSDSEVIIHIMDDGPGIPEAE 373
Cdd:COG4192 515 WELVESRAKPQQITLHI---PDDLMVQGDQVLLEQVLVNLLVNALDaVATQPQISVDlLSNAENLRVAISDNGNGWPLVD 591
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 544826497 374 leAVLQPFYrveTSRnrdTGGTGLGLAIAAQLTAQLEGKLRLA 416
Cdd:COG4192 592 --KLFTPFT---TTK---EVGLGLGLSICRSIMQQFGGDLYLA 626
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
331-430 |
1.63e-04 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 43.75 E-value: 1.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 331 VMTNLLDNALKfgeraaiAIDDSSDSEV-----------IIHIMDDGPGIPEAELEAVLQPFYRVETSrNRdtggtGLGL 399
Cdd:PRK11086 437 ILGNLIENALE-------AVGGEEGGEIsvslhyrngwlHCEVSDDGPGIAPDEIDAIFDKGYSTKGS-NR-----GVGL 503
|
90 100 110
....*....|....*....|....*....|.
gi 544826497 400 AIAAQLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:PRK11086 504 YLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
224-278 |
1.82e-04 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 39.47 E-value: 1.82e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544826497 224 ERAQILASISHDLQTPITRMKLRVEMAGEPEL-------RDKLLNDLDNMSRLVREGIAYAR 278
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELseeqreyLETILREAERLLRLINDLLDLSR 62
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
358-430 |
2.08e-04 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 43.51 E-value: 2.08e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544826497 358 VIIHIMDDGPGIPEAELEAVLQPFYrvetsRNRDTG-GTGLGLAIAAQLTAQLEGKLRLANRAGGGLDVAITLP 430
Cdd:PRK13557 325 VSIAVTDTGSGMPPEILARVMDPFF-----TTKEEGkGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
222-278 |
5.56e-04 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 37.96 E-value: 5.56e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544826497 222 LRERAQILASISHDLQTPITRMKLRVEMAGEP--------ELRDKLLNDLDNMSRLVREGIAYAR 278
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEEllddeeqrEYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
338-430 |
9.81e-04 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 41.38 E-value: 9.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 338 NALKFGERAAIAID--DSSDSEVIIHIMDDGPGIPEAElEAvLQPFyrvetsrnrdtggtglGLAIAAQLTAQLEGKLRL 415
Cdd:PRK10935 482 NAIKHANASEIAVScvTNPDGEHTVSIRDDGIGIGELK-EP-EGHY----------------GLNIMQERAERLGGTLTI 543
|
90
....*....|....*
gi 544826497 416 ANRAGGGLDVAITLP 430
Cdd:PRK10935 544 SQPPGGGTTVSLTFP 558
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
331-431 |
1.28e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 40.97 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 331 VMTNLLDNALKFGERAA-------IAIDDSSDsEVIIHIMDDGPGIPEAELEAVlqpFYRVETSRNRDTGGTGLGLAIAA 403
Cdd:PRK15053 436 IVGNLLDNAFEASLRSDegnkiveLFLSDEGD-DVVIEVADQGCGVPESLRDKI---FEQGVSTRADEPGEHGIGLYLIA 511
|
90 100
....*....|....*....|....*...
gi 544826497 404 QLTAQLEGKLRLANRAGGGLDVAITLPR 431
Cdd:PRK15053 512 SYVTRCGGVITLEDNDPCGTLFSIFIPK 539
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
331-430 |
2.97e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 37.78 E-value: 2.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 331 VMTNLLDNALKFGERAAIAIDDSSDSE-VIIHIMDDGPGIPEAeleavlqpfyrvETSRNRDTggtgLGLAIAAQLTAQL 409
Cdd:cd16951 47 LLQNALKHAFSDREGGTITIRSVVDGDyLRITVIDDGVGLPQD------------EDWPNKGS----LGLQIVRSLVEGE 110
|
90 100
....*....|....*....|.
gi 544826497 410 EGKLRLANRAGGGLDVAITLP 430
Cdd:cd16951 111 LKAFLEVQSAENGTRVNIDIP 131
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-430 |
6.68e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 35.61 E-value: 6.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544826497 328 LRRVMTNLLDNALKFGERAAIAID-DSSDSEVIIHIMDDGPGIPEAeleavlqpfyrvetsrnRDTGGTGLGLAIAAQLT 406
Cdd:cd16917 1 LYRIVQEALTNALKHAGASRVRVTlSYTADELTLTVVDDGVGFDGP-----------------APPGGGGFGLLGMRERA 63
|
90 100
....*....|....*....|....
gi 544826497 407 AQLEGKLRLANRAGGGLDVAITLP 430
Cdd:cd16917 64 ELLGGTLTIGSRPGGGTRVTARLP 87
|
|
| |
