|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
58-386 |
2.82e-67 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 217.88 E-value: 2.82e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 58 AVILFYQVKITFANIRGRFVFAVIIMALFSPFLYIVGFTRWLSKRFVKNINQPLHLLIDASKKIKEKDLDFEIDYYSDNE 137
Cdd:COG5002 58 LLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 138 LGKLcSAFSEMKDELKGSLSAQWKMEQERVEMVEALAHDLKSPLSIILGYTDALIGNNTDDNEKLHRYLTVIRENTEKSA 217
Cdd:COG5002 138 LSAL-LLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIILEEAERLS 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 218 ALVQKMQYTSDLEKSNIQLNLVPINLPEFLRQKVQDYELQAHQKEVELILKMQGNiQSPIQIDVDRLTRIFDNIISNSLQ 297
Cdd:COG5002 217 RLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPED-PLLVLGDPDRLEQVLTNLLDNAIK 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 298 YTPSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGGHSGLGLYIVKQLVEQLGGSVKIENSK 377
Cdd:COG5002 296 YTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEP 375
|
....*....
gi 544954659 378 SGGACVKFW 386
Cdd:COG5002 376 GKGTTFTIT 384
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
151-386 |
9.79e-65 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 206.30 E-value: 9.79e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 151 ELKGSLSAQWKMEQERVEMVEALAHDLKSPLSIILGYTDALIGNNTDDNEKLHRYLTVIRENTEKSAALVQKMQYTSDLE 230
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 231 KSNIQLNLVPINLPEFLRQKVQDYELQAHQKEVELILKMQGNIQsPIQIDVDRLTRIFDNIISNSLQYTPSGGNISITVK 310
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELP-LVYADPELLEQVLANLLDNAIKYSPPGGTITISAR 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544954659 311 DEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGghSGLGLYIVKQLVEQLGGSVKIENSKSGGACVKFW 386
Cdd:COG2205 160 REGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGG--TGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVT 233
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
161-386 |
1.36e-60 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 198.59 E-value: 1.36e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 161 KMEQERVEMVEALAHDLKSPLSIILGYTDALIgnnTDDNEKLHRYLTVIRENTEKSAALVQKMQYTSDLEKSNIQLNLVP 240
Cdd:COG0642 105 EANEAKSRFLANVSHELRTPLTAIRGYLELLL---EELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEP 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 241 INLPEFLRQKVQDYELQAHQKEVELILKMQGNIQsPIQIDVDRLTRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEI 320
Cdd:COG0642 182 VDLAELLEEVVELFRPLAEEKGIELELDLPDDLP-TVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISV 260
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544954659 321 CDSGRGFSSKDLKKALDKFYRGDEARQTKGghSGLGLYIVKQLVEQLGGSVKIENSKSGGACVKFW 386
Cdd:COG0642 261 EDTGPGIPPEDLERIFEPFFRTDPSRRGGG--TGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVT 324
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
280-387 |
1.08e-52 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 170.72 E-value: 1.08e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 280 DVDRLTRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARqTKGGHSGLGLYI 359
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79
|
90 100
....*....|....*....|....*...
gi 544954659 360 VKQLVEQLGGSVKIENSKSGGACVKFWH 387
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
70-386 |
1.29e-35 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 135.09 E-value: 1.29e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 70 ANIRGRFVFAVIIMALFSPFLyIVGFTRWLSKRFVKninqPLHLLIDASKKIKEKDLDFEIDYYSDNELGKLCSAFSEMK 149
Cdd:COG5000 1 SGLQILFLLLLLLIALLLLLL-ALWLALLLARRLTR----PLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 150 DELKGS----------------------------------------------------------------------LSAQ 159
Cdd:COG5000 76 DQLKEQreeleerrryletilenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellreaLERG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 160 WKME-----------------------------------QERV----EMVEALAHDLKSPLSIILGYT----DALIGNNT 196
Cdd:COG5000 156 WQEEieltrdgrrtllvrasplrddgyvivfdditellrAERLaawgELARRIAHEIKNPLTPIQLSAerlrRKLADKLE 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 197 DDNEKLHRYLTVIRENTEKSAALVQKMqytSDLEKSnIQLNLVPINLPEFLRQKVQDYELQAHQKEVELILKMQGNIQsP 276
Cdd:COG5000 236 EDREDLERALDTIIRQVDRLKRIVDEF---LDFARL-PEPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLP-E 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 277 IQIDVDRLTRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYrgdearQTKGGHSGLG 356
Cdd:COG5000 311 VLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF------TTKPKGTGLG 384
|
410 420 430
....*....|....*....|....*....|
gi 544954659 357 LYIVKQLVEQLGGSVKIENSKSGGACVKFW 386
Cdd:COG5000 385 LAIVKKIVEEHGGTIELESRPGGGTTFTIR 414
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
279-386 |
7.18e-33 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 118.91 E-value: 7.18e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 279 IDVDRLTRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGGHsGLGLY 358
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGT-GLGLS 79
|
90 100
....*....|....*....|....*...
gi 544954659 359 IVKQLVEQLGGSVKIENSKSGGACVKFW 386
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTIT 107
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
56-386 |
4.84e-32 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 124.14 E-value: 4.84e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 56 EGAVILFYQVKITFANIRGRFVFAVIIMALFSPFLYIVGFTRWLSKRFVKNINQPLHLLIDASKKIKEKDLDFEIDYYSD 135
Cdd:COG4191 27 LLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEEN 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 136 NELGKLCSAFSEMKDELKGSLSAQWKMEQ-ERV----EMVEALAHDLKSPLSIILGYTDALIG--NNTDDNEKLHRYLTV 208
Cdd:COG4191 107 AELEELERDITELERAEEELRELQEQLVQsEKLaalgELAAGIAHEINNPLAAILGNAELLRRrlEDEPDPEELREALER 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 209 IRENTEKSAALVQKMQYTSDLEKSNIQlnlvPINLPEFLRQKVQDYELQAHQKEVELILKMQGNIqSPIQIDVDRLTRIF 288
Cdd:COG4191 187 ILEGAERAAEIVRSLRAFSRRDEEERE----PVDLNELIDEALELLRPRLKARGIEVELDLPPDL-PPVLGDPGQLEQVL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 289 DNIISNSLQYTPSG--GNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYrgdearQTK--GGHSGLGLYIVKQLV 364
Cdd:COG4191 262 LNLLINAIDAMEEGegGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFF------TTKpvGKGTGLGLSISYGIV 335
|
330 340
....*....|....*....|..
gi 544954659 365 EQLGGSVKIENSKSGGACVKFW 386
Cdd:COG4191 336 EKHGGRIEVESEPGGGTTFTIT 357
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
88-385 |
7.37e-29 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 116.63 E-value: 7.37e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 88 PFLYIVGFTRWLSKRFVKNINQPLHL---------------LIDASKKIKEKDLDFEIDYYSDNELGKLCSAFSEMKDEL 152
Cdd:PRK10604 126 PYLYYLHQMRLLDIALLALIGLSLAFpvflwmrphwqdmlkLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNI 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 153 kGSLSAQWKmeqervEMVEALAHDLKSPLsIILGYTDALIGNNTDDNEK-LHRYLTVIRenteksaALVQKMQYTSDLEK 231
Cdd:PRK10604 206 -NALIASKK------QLIDGIAHELRTPL-VRLRYRLEMSDNLSAAESQaLNRDIGQLE-------ALIEELLTYARLDR 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 232 SNIQLNLVPINLPEFLRQKVQDYELQAHQKEVELILKMQGNiqsPIQIDVDRLTRIFDNIISNSLQYTPSGGNISITVKD 311
Cdd:PRK10604 271 PQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGD---YGALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDG 347
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544954659 312 EKNCISYEicDSGRGFSSKDLKKALDKFYRGDEARQTKGGHSGLGLYIVKQLVEQLGGSVKIENSKSGGACVKF 385
Cdd:PRK10604 348 NQACLIVE--DDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSF 419
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
161-385 |
7.48e-28 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 114.50 E-value: 7.48e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 161 KMEQERVEMVEAL--------------AHDLKSPLSIILGYTDALIGNNTDD-NEKLHRYLTVIRENTEKSAALVQKMQY 225
Cdd:COG4251 263 ELEEELEERTAELersneeleqfayvaSHDLREPLRKISGFSQLLEEDYGDKlDEEGREYLERIRDAAERMQALIDDLLA 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 226 TSDLEKSniQLNLVPINLPEFLRQKVQDYELQAHQKEVELilkmqgNIQSPIQIDVDR--LTRIFDNIISNSLQYTPSG- 302
Cdd:COG4251 343 YSRVGRQ--ELEFEPVDLNELLEEVLEDLEPRIEERGAEI------EVGPLPTVRGDPtlLRQVFQNLISNAIKYSRPGe 414
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 303 -GNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGghSGLGLYIVKQLVEQLGGSVKIENSKSGGA 381
Cdd:COG4251 415 pPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEG--TGIGLAIVKKIVERHGGRIWVESEPGEGA 492
|
....
gi 544954659 382 CVKF 385
Cdd:COG4251 493 TFYF 496
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
110-374 |
1.12e-26 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 110.55 E-value: 1.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 110 PLHLLIDASKKIKEKDLDFEIDyySDN---ELGKLCSAFSEMKDELKGSLsaqwkmeqERVEMVEA-LAHDLKSPLSIIL 185
Cdd:TIGR01386 191 PLRRLSAVAARISPESLDQRLD--PSRapaELRELAQSFNAMLGRLEDAF--------QRLSQFSAdLAHELRTPLTNLL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 186 GYTDALIGNNTDDNEklhrYLTVIRENTE---KSAALVQKMQYTSDLEKSNIQLNLVPINLPEFLRQKVQDYELQAHQKE 262
Cdd:TIGR01386 261 GQTQVALSQPRTGEE----YREVLESNLEeleRLSRMVSDMLFLARADNGQLALERVRLDLAAELAKVAEYFEPLAEERG 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 263 VELilKMQGNIQSPIqiDVDRLTRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRG 342
Cdd:TIGR01386 337 VRI--RVEGEGLVRG--DPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRV 412
|
250 260 270
....*....|....*....|....*....|..
gi 544954659 343 DEARQTKGGHSGLGLYIVKQLVEQLGGSVKIE 374
Cdd:TIGR01386 413 DPARSNSGEGTGLGLAIVRSIMEAHGGRASAE 444
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
93-386 |
1.62e-26 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 110.32 E-value: 1.62e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 93 VGFTRWLskrfvkniNQPLHLLIDASKKIKEKDlDFEIDYYSDNELGKLCSAFSEMKDELKGslsaqwKMEQERVemVEA 172
Cdd:PRK11100 200 AGVVWWL--------NRSIRRLTRYADAVTEGK-PVPLPKLGSSELRELAQALESMRVKLEG------KAYVEQY--VQT 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 173 LAHDLKSPLSIILGYTDALIGNNTDdnEKLHRYLTVIRENTEKSAALVQKMQYTSDLEKSNIQLNLVPINLPEFLRQKVQ 252
Cdd:PRK11100 263 LTHELKSPLAAIRGAAELLQEDPPP--EDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVE 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 253 DYELQAHQKEVELILKMQGniqSPIQIDVDRLTRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEICDSGRGFSSKDL 332
Cdd:PRK11100 341 AREAQAAAKGITLRLRPDD---ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYAL 417
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 544954659 333 KKALDKFY---RGDEARqtKGghSGLGLYIVKQLVEQLGGSVKIENSKSGGACVKFW 386
Cdd:PRK11100 418 PRIFERFYslpRPANGR--KS--TGLGLAFVREVARLHGGEVTLRNRPEGGVLATLT 470
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
156-386 |
2.32e-26 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 108.40 E-value: 2.32e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 156 LSAQWKMEQERV---------EMVEALAHDLKSPLSIILGYTDaLIGNNTDDNEkLHRYLTVIRENTEKSAALVQKMQYT 226
Cdd:COG3852 116 ITERKRLERELRraeklaavgELAAGLAHEIRNPLTGIRGAAQ-LLERELPDDE-LREYTQLIIEEADRLNNLVDRLLSF 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 227 SDLEksniQLNLVPINLPEFLRQKVQDYELQAhQKEVELILKMQGNIqSPIQIDVDRLTRIFDNIISNSLQYTPSGGNIS 306
Cdd:COG3852 194 SRPR----PPEREPVNLHEVLERVLELLRAEA-PKNIRIVRDYDPSL-PEVLGDPDQLIQVLLNLVRNAAEAMPEGGTIT 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 307 ITVKDE----------KNCISYEICDSGRGFSSKDLKKALDKFYRgdearqTKGGHSGLGLYIVKQLVEQLGGSVKIENS 376
Cdd:COG3852 268 IRTRVErqvtlgglrpRLYVRIEVIDNGPGIPEEILDRIFEPFFT------TKEKGTGLGLAIVQKIVEQHGGTIEVESE 341
|
250
....*....|
gi 544954659 377 KSGGACVKFW 386
Cdd:COG3852 342 PGKGTTFRIY 351
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
280-386 |
5.52e-26 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 100.52 E-value: 5.52e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 280 DVDRLTRIFDNIISNSLQYTPSGGNISITVKDEkNCISYEICDSGRGFSSKDLKKALDKFYRGDearQTKGGHSGLGLYI 359
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLSI 77
|
90 100
....*....|....*....|....*..
gi 544954659 360 VKQLVEQLGGSVKIENSKSGGACVKFW 386
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLT 104
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
91-380 |
4.25e-22 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 97.40 E-value: 4.25e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 91 YIVGFT-------RWLSKRfvkNINQPLHLLIDASKKIKEKDLDFEIDYYSDNELGKLCSAFSEMKDELKgslsaqwKME 163
Cdd:PRK10549 168 LIVALStllaalaTFLLAR---GLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLE-------KNE 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 164 QERVEMVEALAHDLKSPLSIILGYTDALI-GNNTDDNEKLHRYLTVIrenteksaALVQKMqyTSDLEksniQLNL---- 238
Cdd:PRK10549 238 QMRRDFMADISHELRTPLAVLRGELEAIQdGVRKFTPESVASLQAEV--------GTLTKL--VDDLH----QLSLsdeg 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 239 ------VPINLPEFLRQKVQDYELQAHQKEVELILKMQGNIqsPIQIDVDRLTRIFDNIISNSLQYTPSGGNISITVKDE 312
Cdd:PRK10549 304 alayrkTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSA--TVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQR 381
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544954659 313 KNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGGHSGLGLYIVKQLVEQLGGSVKIENSKSGG 380
Cdd:PRK10549 382 DKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGG 449
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
76-386 |
1.08e-20 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 93.05 E-value: 1.08e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 76 FVFAVIIMALfspflyIVGFTrWLskrFVKNINQPLHLLIDASKKIKEKDLDFEIDYYSDNELGKLCSAFSEMKDELKGs 155
Cdd:PRK09467 156 FRYTLAIGLL------SVAGG-WL---FIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIKQ- 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 156 lsaqwkMEQERVEMVEALAHDLKSPLSIIL----------GYTDALIGNNTDD-NEKLHRYLTVIRenteksaaLVQKMQ 224
Cdd:PRK09467 225 ------LEDDRTLLMAGVSHDLRTPLTRIRlatemmseedGYLAESINKDIEEcNAIIEQFIDYLR--------TGQEMP 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 225 YTSdleksnIQLNLVpinlpefLRQKVQ---DYElqahqKEVELILKMqgniqSPIQIDVDRLT--RIFDNIISNSLQYt 299
Cdd:PRK09467 291 MEM------ADLNAL-------LGEVIAaesGYE-----REIETALQP-----GPIEVPMNPIAikRALANLVVNAARY- 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 300 pSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGghSGLGLYIVKQLVEQLGGSVKIENSKSG 379
Cdd:PRK09467 347 -GNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSSG--TGLGLAIVKRIVDQHNGKVELGNSEEG 423
|
....*..
gi 544954659 380 GACVKFW 386
Cdd:PRK09467 424 GLSARAW 430
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
284-386 |
8.57e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 83.53 E-value: 8.57e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 284 LTRIFDNIISNSLQYTPSGGNISITVkdEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGGHSGLGLYIVKQL 363
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQ--DGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|...
gi 544954659 364 VEQLGGSVKIENSKSGGACVKFW 386
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIW 101
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
280-380 |
9.78e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 83.67 E-value: 9.78e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 280 DVDRLTRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGGHSGLGLYI 359
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|.
gi 544954659 360 VKQLVEQLGGSVKIENSKSGG 380
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGG 101
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
163-385 |
2.82e-19 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 89.71 E-value: 2.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 163 EQERVEMVEALAHDLKSPLSIILGYTDALIGNNTDDNEKLHRYLTVIRENTEKSAALVQKMQYTSDLEKSNIQLNLVPIN 242
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGSPHARQASEIRQQVLNTTRLVNNLLDMARIQSGGFNLRKEWLT 740
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 243 LPEFLRQKVQ--DYELQAHQKEVELILKMQgniqsPIQIDVDRLTRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEI 320
Cdd:PRK10490 741 LEEVVGSALQmlEPGLSGHPINLSLPEPLT-----LIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDV 815
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544954659 321 CDSGRGFSSKDLKKALDKFYRGDEARQTKGghSGLGLYIVKQLVEQLGGSVKIENSKSGGACVKF 385
Cdd:PRK10490 816 WDNGPGIPPGQEQLIFDKFARGNKESAIPG--VGLGLAICRAIVEVHGGTIWAENRPEGGACFRV 878
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
82-385 |
4.97e-19 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 88.87 E-value: 4.97e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 82 IMALFSPFLYIVGFTR--WLSKRF--VKNINQPL-HLLIDASKKiKEKDLDFEIDYY-SDNELGKLCSAfSEMKD---EL 152
Cdd:PRK11360 284 ITTMNPAAEVITGLQRheLVGKPYseLFPPNTPFaSPLLDTLEH-GTEHVDLEISFPgRDRTIELSVST-SLLHNthgEM 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 153 KGSL------SAQWKME-----QERV----EMVEALAHDLKSPLSIILGYtdALIGNNTDDNEKLHRYLTVIRENTEKSA 217
Cdd:PRK11360 362 IGALvifsdlTERKRLQrrvarQERLaalgELVAGVAHEIRNPLTAIRGY--VQIWRQQTSDPPSQEYLSVVLREVDRLN 439
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 218 ALVQKMQYTSDLEKSNIQlnlvPINLPEFLRQKVQDYELQAHQKEVELILKMQGNIqSPIQIDVDRLTRIFDNIISNSLQ 297
Cdd:PRK11360 440 KVIDQLLEFSRPRESQWQ----PVSLNALVEEVLQLFQTAGVQARVDFETELDNEL-PPIWADPELLKQVLLNILINAVQ 514
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 298 YTPSGGNISITVKDEKN-CISYEICDSGRGFSSKDLKKALDKFYrgdearQTKGGHSGLGLYIVKQLVEQLGGSVKIENS 376
Cdd:PRK11360 515 AISARGKIRIRTWQYSDgQVAVSIEDNGCGIDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESE 588
|
....*....
gi 544954659 377 KSGGACVKF 385
Cdd:PRK11360 589 PGVGTTFTL 597
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
284-386 |
2.07e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 79.80 E-value: 2.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 284 LTRIFDNIISNSLQYtpSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGghSGLGLYIVKQL 363
Cdd:cd16950 1 LKRVLSNLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSG--TGLGLAIVQRI 76
|
90 100
....*....|....*....|...
gi 544954659 364 VEQLGGSVKIENSKSGGACVKFW 386
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIE 99
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
110-374 |
4.11e-18 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 85.59 E-value: 4.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 110 PLHLLIDASKKIKEKDLDFEIDYYS-DNELGKLCSAFSEMKDELKGSLSAQWKMEQErvemveaLAHDLKSPLSIILGYT 188
Cdd:PRK09835 212 PIRSVSRQIQNITSKDLDVRLDPQTvPIELEQLVLSFNHMIERIEDVFTRQSNFSAD-------IAHEIRTPITNLITQT 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 189 DALIGNNTDDNEkLHRYLTVIRENTEKSAALVQKMQYTSDLEKSNIQLNLVPINLPEFLRQKVQDYELQAHQKEVELilK 268
Cdd:PRK09835 285 EIALSQSRSQKE-LEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVEL--R 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 269 MQGniqSPIQIDVD--RLTRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEAR 346
Cdd:PRK09835 362 FVG---DPCQVAGDplMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSR 438
|
250 260
....*....|....*....|....*...
gi 544954659 347 QTKGGHSGLGLYIVKQLVEQLGGSVKIE 374
Cdd:PRK09835 439 QRKGEGSGIGLAIVKSIVVAHKGTVAVT 466
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
95-385 |
7.24e-18 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 84.68 E-value: 7.24e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 95 FTRWLSKRfvkNINQPLHLLIDAskkikEKDLDFEIDYYSDNELGKLCSAFSEMKdelkgslsaqwKMEQERVEMVEALA 174
Cdd:PRK11006 152 FTQYLKTR---DFSRPLTLVLNN-----GRHLEIRVMPYTEGQLLMVARDVTQMH-----------QLEGARRNFFANVS 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 175 HDLKSPLSIILGYTDaLIGNNTDDNEKLHRYLTVIRENTEKSAALVQKMQYTSDLEKS-NIQLNLVpINLPEFLRqkvqd 253
Cdd:PRK11006 213 HELRTPLTVLQGYLE-MMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAApTIDLNEK-VDVPMMLR----- 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 254 yelqAHQKEVELIlkmqGNIQSPIQIDVDRLTRIF----------DNIISNSLQYTPSGGNISITVKDEKNCISYEICDS 323
Cdd:PRK11006 286 ----VLEREAQTL----SQGKHTITFEVDNSLKVFgnedqlrsaiSNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDN 357
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544954659 324 GRGFSSKDLKKALDKFYRGDEARQTKGGHSGLGLYIVKQLVEQLGGSVKIENSKSGGACVKF 385
Cdd:PRK11006 358 GPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSF 419
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
280-374 |
9.83e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 78.10 E-value: 9.83e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 280 DVDRLTRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGGhSGLGLYI 359
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQES-TGMGLYL 80
|
90
....*....|....*
gi 544954659 360 VKQLVEQLGGSVKIE 374
Cdd:cd16948 81 VKKLCDKLGHKIDVE 95
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
168-383 |
1.51e-17 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 83.36 E-value: 1.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 168 EMVEAL---AHDLKSPLSIILGYTDalignnTDDNEKLHRYLTvirenteksaALVQKMQYTSDLEKSNIQlnlvPINLP 244
Cdd:COG3290 188 ELAEALraqRHDFRNHLHTISGLLQ------LGEYDEALEYID----------EISEELQELIDSLLSRIG----NPVLA 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 245 EFLRQKVQdyelQAHQKEVELILKMQGNIqSPIQIDVDRLTRIFDNIISNSLQYT----PSGGNISITVKDEKNCISYEI 320
Cdd:COG3290 248 ALLLGKAA----RARERGIDLTIDIDSDL-PDLPLSDTDLVTILGNLLDNAIEAVeklpEEERRVELSIRDDGDELVIEV 322
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544954659 321 CDSGRGFSSKDLKKAldkFYRGDEarqTK-GGHSGLGLYIVKQLVEQLGGSVKIENSKSGGACV 383
Cdd:COG3290 323 EDSGPGIPEELLEKI---FERGFS---TKlGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVF 380
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
163-386 |
2.59e-17 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 83.30 E-value: 2.59e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 163 EQERVEMVEAL-------AHDLKSPLSIILGYTdALIGNNTDDNEKLHRYLTVIRENTEKSAALVQKMqytsdLEKSN-I 234
Cdd:PRK10364 227 EMKRKEKLVALghlaagvAHEIRNPLSSIKGLA-KYFAERAPAGGEAHQLAQVMAKEADRLNRVVSEL-----LELVKpT 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 235 QLNLVPINLPEFLRQKVQDYELQAHQKEVELILKMQGNIQSpIQIDVDRLTRIFDNIISNSLQYTPSGGNISITVKDEKN 314
Cdd:PRK10364 301 HLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPE-IQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGA 379
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544954659 315 CISYEICDSGRGFSSKDLKKALDKFYrgdearQTKGGHSGLGLYIVKQLVEQLGGSVKIENSKSGGACVKFW 386
Cdd:PRK10364 380 GVKISVTDSGKGIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLW 445
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
280-381 |
4.35e-17 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 76.38 E-value: 4.35e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 280 DVDRLTRIFDNIISNSLQYTPSGGNISITV-KDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGGHSGLGLY 358
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILeKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100
....*....|....*....|...
gi 544954659 359 IVKQLVEQLGGSVKIENSKSGGA 381
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGA 103
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
284-374 |
5.69e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 75.89 E-value: 5.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 284 LTRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGghSGLGLYIVKQL 363
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEG--AGLGLSIAKAI 78
|
90
....*....|.
gi 544954659 364 VEQLGGSVKIE 374
Cdd:cd16923 79 IELHGGSASAE 89
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
168-385 |
9.09e-17 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 81.56 E-value: 9.09e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 168 EMVEALAHDLKSPLSIILGYTDALIGNNTDDNEklhRYLTVIRENTEKSAALVQKMQYTSDLEKSNIQlnlvPINLPEFL 247
Cdd:COG5809 272 ELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQK---TYLDIMLSELDRIESIISEFLVLAKPQAIKYE----PKDLNTLI 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 248 RQKVQDYELQAHQKEVELILKMQGNIqSPIQIDVDRLTRIFDNIISNSLQYTPSGGNISITVKD-EKNCISYEICDSGRG 326
Cdd:COG5809 345 EEVIPLLQPQALLKNVQIELELEDDI-PDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAeDDDKVVISVTDEGCG 423
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 544954659 327 FSSKDLKKALDKFYrgdearQTKGGHSGLGLYIVKQLVEQLGGSVKIENSKSGGACVKF 385
Cdd:COG5809 424 IPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSI 476
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
273-386 |
2.58e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 71.67 E-value: 2.58e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 273 IQSPIQI--DVDRLTRIFDNIISNSLQYTPSGGNISITVKDEKNCIsYEICDSGRGFSSKDLKKALDKFYRGDeARQTKG 350
Cdd:cd16940 1 SAADIQVqgDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSD-GQNYGG 78
|
90 100 110
....*....|....*....|....*....|....*.
gi 544954659 351 ghSGLGLYIVKQLVEQLGGSVKIENSKSGGACVKFW 386
Cdd:cd16940 79 --SGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVR 112
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
166-375 |
3.07e-15 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 77.85 E-value: 3.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 166 RVEMVEALAHDLKSPLSIILGYTDALIGNNTDDNEKLHRyLTVIRENTEKSAALVQKMQYTSDLEKSNIQLNLVPINLPE 245
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEA-ISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 246 FLRQKVQDYELQAHQKEVELILKMQGNIQSPIQIDVDRLTRIFDNIISNSLQYTPSGGnISIT-----VKDEKNCISYEI 320
Cdd:PRK09959 791 LVQNTCHSFGAIAASKSIALSCSSTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGA-VKITtslghIDDNHAVIKMTI 869
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 544954659 321 CDSGRGFSSKDLKKALDKFYRGDEARQTKGghSGLGLYIVKQLVEQLGGSVKIEN 375
Cdd:PRK09959 870 MDSGSGLSQEEQQQLFKRYSQTSAGRQQTG--SGLGLMICKELIKNMQGDLSLES 922
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
278-375 |
3.31e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 71.39 E-value: 3.31e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 278 QIDVDRLTRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGGHSGLGL 357
Cdd:cd16947 15 NANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGL 94
|
90
....*....|....*...
gi 544954659 358 YIVKQLVEQLGGSVKIEN 375
Cdd:cd16947 95 TITKRLAESMGGSIYVNS 112
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
173-382 |
1.17e-14 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 75.75 E-value: 1.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 173 LAHDLKSPLSIILGYTDALIgnNTDDNEKLHRYLtvireNTEKSAAL-----------VQKMqytsdlEKSNIQLNLVPI 241
Cdd:PRK11091 290 ISHELRTPLNGIVGLSRILL--DTELTAEQRKYL-----KTIHVSAItlgnifndiidMDKM------ERRKLQLDNQPI 356
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 242 NLPEFLRQKVQDYELQAHQKEVELILKMQGNIQSPIQIDVDRLTRIFDNIISNSLQYTPSGGnISITV-KDEKNCISYEI 320
Cdd:PRK11091 357 DFTDFLADLENLSGLQAEQKGLRFDLEPLLPLPHKVITDGTRLRQILWNLISNAVKFTQQGG-VTVRVrYEEGDMLTFEV 435
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 321 CDSGRGFSSKDLKKALDKFYrgdearQTKGGH-------SGLGLYIVKQLVEQLGGSVKIeNSKSG-GAC 382
Cdd:PRK11091 436 EDSGIGIPEDELDKIFAMYY------QVKDSHggkpatgTGIGLAVSKRLAQAMGGDITV-TSEEGkGSC 498
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
162-384 |
1.44e-14 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 74.69 E-value: 1.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 162 MEQERVEMVEAlAHDLKSPLSIILGYTDaLIGNNTDDNEKLHRYLTVIRENTEKSAALVQKMQYTSDLEK-SNIQlNLVP 240
Cdd:PRK10337 234 MVRERRFTSDA-AHELRSPLAALKVQTE-VAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSlDNLQ-DVAE 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 241 INLPEFLRQKVQDYELQAHQKEVELILKMQGniqSPI--QIDVDRLTRIFDNIISNSLQYTPSGGNISITVkdekNCISY 318
Cdd:PRK10337 311 IPLEDLLQSAVMDIYHTAQQAGIDVRLTLNA---HPVirTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTL----NARNF 383
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544954659 319 EICDSGRGFSSKDLKKALDKFYR--GdearQTKGGhSGLGLYIVKQLVEQLGGSVKIENSKSGGACVK 384
Cdd:PRK10337 384 TVRDNGPGVTPEALARIGERFYRppG----QEATG-SGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAK 446
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
78-383 |
3.87e-14 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 73.95 E-value: 3.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 78 FAVIIMALFSpFLYIVGFTRWL-SKRFVKNINQplhlLIDASKKIKEKDLDFEIDYYSDNELGKL-------CSAFSEMK 149
Cdd:COG4192 326 ILLLAIALLS-LLLAVLINYFYvRRRLVKRLNA----LSDAMAAIAAGDLDVPIPVDGNDEIGRIarllrvfRDQAIEKT 400
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 150 DELKGSLSAQWKMEQERVEMVE----------------ALAHDLKSPLSIILGYT----DALIGNNTddnEKLHRYLTVI 209
Cdd:COG4192 401 QELETEIEERKRIEKNLRQTQDeliqaakmavvgqtmtSLAHELNQPLNAMSMYLfsakKALEQENY---AQLPTSLDKI 477
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 210 RENTEKSAALVQKMQYTSdlEKSNIQLNLVPinlpefLRQKVQD-YELQAHQKEvelilKMQGNIQSP----IQIDVDRL 284
Cdd:COG4192 478 EGLIERMDKIIKSLRQFS--RKSDTPLQPVD------LRQVIEQaWELVESRAK-----PQQITLHIPddlmVQGDQVLL 544
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 285 TRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEICDSGRGFSskDLKKALDKFYrgdearQTKGGHSGLGLYIVKQLV 364
Cdd:COG4192 545 EQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFT------TTKEVGLGLGLSICRSIM 616
|
330
....*....|....*....
gi 544954659 365 EQLGGSVKIENSKSGGACV 383
Cdd:COG4192 617 QQFGGDLYLASTLERGAMV 635
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
284-385 |
1.22e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 66.30 E-value: 1.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 284 LTRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEicDSGRGFSSKDLKKALDKFYRGDEARQTKGGHSGLGLYIVKQL 363
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIVE--DDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|..
gi 544954659 364 VEQLGGSVKIENSKSGGACVKF 385
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRL 100
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
290-385 |
2.72e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 65.59 E-value: 2.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 290 NIISNSLQYTPSGGnISITVK-----DEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGGHSGLGLYIVKQLV 364
Cdd:cd16922 7 NLLGNAIKFTEEGE-VTLRVSleeeeEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKKLV 85
|
90 100
....*....|....*....|..
gi 544954659 365 EQLGGSVKIEnSKSG-GACVKF 385
Cdd:cd16922 86 ELMGGDISVE-SEPGqGSTFTF 106
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
288-386 |
5.38e-13 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 69.96 E-value: 5.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 288 FDNIISNSLQYTPSggNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGGHSGLGLYIVKQLVEQL 367
Cdd:PRK09470 358 LENIVRNALRYSHT--KIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQH 435
|
90
....*....|....*....
gi 544954659 368 GGSVKIENSKSGGACVKFW 386
Cdd:PRK09470 436 RGWVKAEDSPLGGLRLTIW 454
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
78-385 |
7.39e-13 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 70.06 E-value: 7.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 78 FAVIIMALFSPFLYIVgFTRWLSK---RFVKNINQ--PLHLlidaSKKIKEKDLDfeidyysdnELGKLCSAFSEMKDEL 152
Cdd:PRK15347 301 FALLILVLLTSVLFLL-LRRYLAKplwRFVDIINKtgPAAL----EPRLPENRLD---------ELGSIAKAYNQLLDTL 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 153 KGSLSAQWKMEQER-VEMVEA-----------------LAHDLKSPLSIILGYTDALigNNTDDNEKLHRYLTVIRENTE 214
Cdd:PRK15347 367 NEQYDTLENKVAERtQALAEAkqraeqankrksehlttISHEIRTPLNGVLGALELL--QNTPLTAEQMDLADTARQCTL 444
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 215 KSAALVQKMQYTSDLEKSNIQLNLVPINLPEFLRQKVQDYELQAHQKEVELILKMQGNIQSPIQIDVDRLTRIFDNIISN 294
Cdd:PRK15347 445 SLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVPLYLHLDSLRLRQILVNLLGN 524
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 295 SLQYTPSGGnISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEarqTKGGhSGLGLYIVKQLVEQLGGSVKIe 374
Cdd:PRK15347 525 AVKFTETGG-IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT---HSQG-TGLGLTIASSLAKMMGGELTL- 598
|
330
....*....|..
gi 544954659 375 NSKSG-GACVKF 385
Cdd:PRK15347 599 FSTPGvGSCFSL 610
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
55-296 |
1.06e-12 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 69.37 E-value: 1.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 55 IEGAVILFYQVKITFANIRGRFVFAVIIMALfspflyIVGFTRWLSKRFVKninqPLHLLIDASKKIKEKDLDFEIDYYS 134
Cdd:COG2770 194 LLGGLLLVVLLEAALAALLLLLLLALLALLL------ALLLALLLARRITR----PLRRLAEAARRIAAGDLDVRIPVSR 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 135 DNELGKLCSAFSEMKDELKGSLSAQWKMEQERVEMVEALAHDLKSPLSIILGYTDALIGNNTDDNEKLHRYLTVIRENTE 214
Cdd:COG2770 264 KDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLL 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 215 KSAALVQkMQYTSDLEKSNIQLNLVPINLPEFLRQKVQDYELQAHQKEVELILKMQGNIQSPIQIDVDRLTRIFDNIISN 294
Cdd:COG2770 344 LLLAADL-LLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALL 422
|
..
gi 544954659 295 SL 296
Cdd:COG2770 423 AL 424
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
284-375 |
6.36e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 61.82 E-value: 6.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 284 LTRIFDNIISNSLQYTP-SGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGGHSGLGLYIVKQ 362
Cdd:cd16953 1 LGQVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80
|
90
....*....|...
gi 544954659 363 LVEQLGGSVKIEN 375
Cdd:cd16953 81 IIEAHGGISVAEN 93
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
59-385 |
7.46e-12 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 66.58 E-value: 7.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 59 VILFYQVKITFANIRGRFVFAVIIMALFSPFLYIVGFtrwlskRFVKNINQPLHLLIDASKKIKEKDLdFEIDYYSDNEL 138
Cdd:COG2972 139 LVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSY------LLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEI 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 139 GKLCSAFSEMKDELKGSLSAQWKMEQERVEMvEALA-------HDLKSPLSIILGYTDalignnTDDNEKLHRYLTvire 211
Cdd:COG2972 212 GILARSFNEMVERIKELIEEVYELELEKKEA-ELKAlqaqinpHFLFNTLNSIRWLAE------LEDPEEAEEMLE---- 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 212 nteksaALVQKMQYTsdLEKSNiqlNLVPINlpeflrqkvqdyelqahqKEVELI--------LKMQGNIQspIQIDVDR 283
Cdd:COG2972 281 ------ALSKLLRYS--LSKGD---ELVTLE------------------EELELIksyleiqkLRFGDRLE--VEIEIDE 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 284 LTR-----------IFDNIISNSLQYTPSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFyrgdearQTKGGH 352
Cdd:COG2972 330 ELLdllipklilqpLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEG 402
|
330 340 350
....*....|....*....|....*....|....*.
gi 544954659 353 SGLGLYIVKQLVEQL---GGSVKIENSKSGGACVKF 385
Cdd:COG2972 403 RGIGLRNVRERLKLYygeEYGLEIESEPGEGTTVTI 438
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
288-381 |
2.52e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 59.91 E-value: 2.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 288 FDNIISNSLQYTPSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGGHSGLGLYIVKQLVEQL 367
Cdd:cd16952 5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRH 84
|
90
....*....|....
gi 544954659 368 GGSVKIENSKSGGA 381
Cdd:cd16952 85 DARLLIASELGKGS 98
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
168-384 |
2.56e-11 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 64.75 E-value: 2.56e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 168 EMVEALAHDLKSPLSIILGYTDaLIGNNTDDNEKlhrYLTVIRENTEKSAALVQKMQYtsdLEKsNIQLNLVPINLPEFL 247
Cdd:COG5805 289 QLAAGIAHEIRNPLTSIKGFLQ-LLQPGIEDKEE---YFDIMLSELDRIESIISEFLA---LAK-PQAVNKEKENINELI 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 248 RQKVQDYELQAHQKEVELILKMQGNIQSpIQIDVDRLTRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEICDSGRGF 327
Cdd:COG5805 361 QDVVTLLETEAILHNIQIRLELLDEDPF-IYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGI 439
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 544954659 328 SSKDLKKALDKFYrgdearQTKGGHSGLGLYIVKQLVEQLGGSVKIENSKSGGACVK 384
Cdd:COG5805 440 PEERLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFT 490
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
148-385 |
8.21e-11 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 63.05 E-value: 8.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 148 MKDEL------KGSLSAQWKMeQERV-EMveaLAHDLKSPLsiilgyTDALI-------GNNTDDNEK----LHRYLTVI 209
Cdd:PRK09303 130 LSDELfvlrqeNETLLEQLKF-KDRVlAM---LAHDLRTPL------TAASLaletlelGQIDEDTELkpalIEQLQDQA 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 210 RENTEKSAALVQKMQYTSDLEKSNIQLNLVPINLPEFLRQKVQDYELQAHQKEVELILKMQGNIqSPIQIDVDRLTRIFD 289
Cdd:PRK09303 200 RRQLEEIERLITDLLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDL-PSVYADQERIRQVLL 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 290 NIISNSLQYTPSGGNISITV---KDEKNCISyeICDSGRGFSSKDLKKALDKFYRGDEARQTKGghSGLGLYIVKQLVEQ 366
Cdd:PRK09303 279 NLLDNAIKYTPEGGTITLSMlhrTTQKVQVS--ICDTGPGIPEEEQERIFEDRVRLPRDEGTEG--YGIGLSVCRRIVRV 354
|
250
....*....|....*....
gi 544954659 367 LGGSVKIENSKSGGACVKF 385
Cdd:PRK09303 355 HYGQIWVDSEPGQGSCFHF 373
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
75-389 |
9.83e-11 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 63.71 E-value: 9.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 75 RFVFAVIIMALFSpflyiVGFTRWLSKRFVKNINQPLHLLIDASKKIKEKDLDFEIDYYSDNELgklcsafsemkDELK- 153
Cdd:PRK11107 175 REIFIAFLMLLLG-----IGLALLFAFRLMRDVTGPIRNMVNTVDRIRRGQLDSRVEGNMLGEL-----------DMLKn 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 154 ------GSLSAQW-------------------KMEQERVEM-------VEA-------LA---HDLKSPLSIILGYTDAL 191
Cdd:PRK11107 239 ginamaMSLSAYHeemqqnidqatsdlretleQMEIQNVELdlakkraQEAariksefLAnmsHELRTPLNGVIGFTRQT 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 192 IgnNTDDNEKLHRYLTVIrentEKSA----ALVQKMQYTSDLEKSNIQLNLVPINLPEFLRQKVQdyeLQ---AHQKEVE 264
Cdd:PRK11107 319 L--KTPLTPTQRDYLQTI----ERSAnnllAIINDILDFSKLEAGKLVLENIPFSLRETLDEVVT---LLahsAHEKGLE 389
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 265 LILKMQGNIQSPIQIDVDRLTRIFDNIISNSLQYTPSGgNISITV-----KDEKNCISYEICDSGRGFSSKDLKKALDKF 339
Cdd:PRK11107 390 LTLNIDPDVPDNVIGDPLRLQQIITNLVGNAIKFTESG-NIDILVelralSNTKVQLEVQIRDTGIGISERQQSQLFQAF 468
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 544954659 340 YRGDEARQTKGGHSGLGLYIVKQLVEQLGGSVKIENSKSGGACvkFWHSI 389
Cdd:PRK11107 469 RQADASISRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGST--FWFHL 516
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
284-384 |
1.03e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 58.32 E-value: 1.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 284 LTRIFDNIiSNSLQYTPSG-GNISITVKDEKNC-ISYEICDSGRGFSSKDLKKALDKFYrgdearQTKGGHSGLGLYIVK 361
Cdd:cd16944 9 LTNILKNA-AEAIEGRPSDvGEVRIRVEADQDGrIVLIVCDNGKGFPREMRHRATEPYV------TTRPKGTGLGLAIVK 81
|
90 100
....*....|....*....|...
gi 544954659 362 QLVEQLGGSVKIENSKSGGACVK 384
Cdd:cd16944 82 KIMEEHGGRISLSNREAGGACIR 104
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
218-385 |
1.73e-10 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 62.23 E-value: 1.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 218 ALVQKMQYTSDleksniqlNLVPINLPEFLRQKVQDYELQAHQKEVELILKMQgniqsPIQIDVDRLTR---IFDNIISN 294
Cdd:COG3920 344 ALVHELLYQSE--------DWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGP-----DVELPADAAVPlglILNELVTN 410
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 295 SLQYT-PSG--GNISITVKDEKNCISYEICDSGRGFSskdlkkaldkfyrgdeARQTKGGHSGLGLYIVKQLVEQLGGSV 371
Cdd:COG3920 411 ALKHAfLSGegGRIRVSWRREDGRLRLTVSDNGVGLP----------------EDVDPPARKGLGLRLIRALVRQLGGTL 474
|
170
....*....|....
gi 544954659 372 KIENSKsgGACVKF 385
Cdd:COG3920 475 ELDRPE--GTRVRI 486
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
161-382 |
3.67e-10 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 61.84 E-value: 3.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 161 KMEQERVEMVEALAHDLKSPLSIILGYTDALIGNNTDDNEKlhRYLTVIRENTEKSAALVQKMQYTSDLE--KSNIQLNL 238
Cdd:PRK11466 439 KASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQR--DDLRAITDSGESLLTILNDILDYSAIEagGKNVSVSD 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 239 VPINLPEFLRQKVQDYELQAHQKEVELILKMQGNIQSPIQIDVDRLTRIFDNIISNSLQYTPSGGNISITVKDEKNCIsY 318
Cdd:PRK11466 517 EPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDLPTALMGDPRRIRQVITNLLSNALRFTDEGSIVLRSRTDGEQWL-V 595
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544954659 319 EICDSGRGFSSKDLKKALDKFYRGDEARqtkgGHSGLGLYIVKQLVEQLGGSVKIENSKSGGAC 382
Cdd:PRK11466 596 EVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSC 655
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
284-385 |
7.73e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 55.80 E-value: 7.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 284 LTRIFDNIISNSLQYTPSG--GNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEarQTKGGHSGLGLYIVK 361
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....
gi 544954659 362 QLVEQLGGSVKIENSKSGGACVKF 385
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYF 102
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
55-314 |
1.00e-09 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 59.90 E-value: 1.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 55 IEGAVILFYQVKITFANIRGRFVFAVIIMALfspflyIVGFTRWLSKRFVKninqPLHLLIDASKKIKEKDLDFEIDYYS 134
Cdd:COG3850 100 LLLLLLLLLLLLAAAINRKLALLRLLLALLL------ALLLAYLLRRRIVR----PLRRLTQAAERIARGDFDARVPVSG 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 135 DNELGKLCSAFSEMKDELKGSLSAqwkMEQERVEMVEALAHDLKSPLSI-----ILGYTDALIGNNTDDNEKLHRYLTVI 209
Cdd:COG3850 170 RDELGTLARAFNRMADELQELYAE---LEEEEELEAELELLALLDELLLlaallLLLALLLALLLAALLAALLLLLLLQD 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 210 RENTEKSAALVQKMQYTSDLEKSNIQLNLVPIN-----LPEFLRQKVQDYELQAHQKEVELILKMQGNIQSPIQIDVDRL 284
Cdd:COG3850 247 ALAESELLALNILAGLLELLLALLLLLLASALLlleleLLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANA 326
|
250 260 270
....*....|....*....|....*....|
gi 544954659 285 TRIFDNIISNSLQYTPSGGNISITVKDEKN 314
Cdd:COG3850 327 SLLLIALASVVAALLELASILALQAALEAA 356
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
284-382 |
4.85e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 53.45 E-value: 4.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 284 LTRIFDNIISNSLQYT----PSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYrgdearQTKG-GHSGLGLY 358
Cdd:cd16915 1 LITIVGNLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV------STKGqGERGIGLA 74
|
90 100
....*....|....*....|....
gi 544954659 359 IVKQLVEQLGGSVKIENSKSGGAC 382
Cdd:cd16915 75 LVRQSVERLGGSITVESEPGGGTT 98
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
261-384 |
1.94e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 52.63 E-value: 1.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 261 KEVELILKMQGNIQSPIqiDVDRLTRIFDNIISNSLQYTPSGGNISITVKDEKncisYEIC--DSGRGFSSKDLKKALDK 338
Cdd:cd16954 17 KGVSISLDISPELRFPG--ERNDLMELLGNLLDNACKWCLEFVEVTARQTDGG----LHLIvdDDGPGVPESQRSKIFQR 90
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 544954659 339 FYRGDEARQtkgGHsGLGLYIVKQLVEQLGGSVKIENSKSGGACVK 384
Cdd:cd16954 91 GQRLDEQRP---GQ-GLGLAIAKEIVEQYGGELSLSDSPLGGARFE 132
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
163-223 |
3.44e-08 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 49.90 E-value: 3.44e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544954659 163 EQERVEMVEALAHDLKSPLSIILGYTDALIgNNTDDNEKLHRYLTVIRENTEKSAALVQKM 223
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLE-EELLDDEEQREYLERIREEAERLLRLINDL 60
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
284-380 |
4.19e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 50.92 E-value: 4.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 284 LTRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYrgDEARQTKGGHS-GLGLYIVKQ 362
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFY--SLPRPHSGQKStGLGLAFVQE 82
|
90
....*....|....*...
gi 544954659 363 LVEQLGGSVKIENSKSGG 380
Cdd:cd16945 83 VAQLHGGRITLRNRPDGV 100
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
290-386 |
1.10e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 50.07 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 290 NIISNSLQYTPSGGNISITVKDEK---------------NCISYEICDSGRGFSSKDLKKALDKFYrgdearQTK--GGH 352
Cdd:cd16919 7 NLAVNARDAMPEGGRLTIETSNQRvdadyalnyrdlipgNYVCLEVSDTGSGMPAEVLRRAFEPFF------TTKevGKG 80
|
90 100 110
....*....|....*....|....*....|....
gi 544954659 353 SGLGLYIVKQLVEQLGGSVKIENSKSGGACVKFW 386
Cdd:cd16919 81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIY 114
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
249-374 |
1.67e-07 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 52.99 E-value: 1.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 249 QKVQDYELQ-AHQKEVElILKMQGNIQSPI-------------------QIDVD-------------RLTRIFDNIISNS 295
Cdd:PRK11086 367 DQLEDYILKtANNYQEE-IGSLLGKIKSPViagfllgkisrarelgitlIISEDsqlpdsgdedqvhELITILGNLIENA 445
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 296 LQYTPS--GGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYrgdearQTKGGHSGLGLYIVKQLVEQLGGSVKI 373
Cdd:PRK11086 446 LEAVGGeeGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY------STKGSNRGVGLYLVKQSVENLGGSIAV 519
|
.
gi 544954659 374 E 374
Cdd:PRK11086 520 E 520
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
81-385 |
1.94e-07 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 52.28 E-value: 1.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 81 IIMALFSPFLYIVGFTRWLSKRFVKNINQPLHLLidaSKKIKEKDLD--FEIDYYSD-NELGKLCSAFSEMKDELKGSLs 157
Cdd:PRK10755 59 AVASLLVPSLVMVSLTLLICFQAVRWITRPLAEL---QKELEARTADnlTPIAIHSStLEIEAVTSALNQLVSRLTSTL- 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 158 aqwkmEQERVEMVEAlAHDLKSPLSII---------LGYTD-----ALIGNNTDDNEKLhryLTVIRENTEKSAALVQKM 223
Cdd:PRK10755 135 -----DQERLFTADV-AHELRTPLAGIrlhlellekQHHIDvapliARLDQMMHTVEQL---LQLARAGQSFSSGHYQTV 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 224 QYTSDLeksniqlnLVPI--NLPEFLRQKVQDYELQahqkEVELILKMQGniqspiqiDVDRLTRIFDNIISNSLQYTPS 301
Cdd:PRK10755 206 KLLEDV--------ILPSqdELSEMLEQRQQTLLLP----ESAADITVQG--------DATLLRLLLRNLVENAHRYSPE 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 302 GGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDearqTKGGHSGLGLYIVKQLVEQLGGSVKIENSKSGG- 380
Cdd:PRK10755 266 GSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHGQFFLQNRQERSg 341
|
....*..
gi 544954659 381 --ACVKF 385
Cdd:PRK10755 342 trAWVWL 348
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
165-230 |
2.25e-07 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 47.59 E-value: 2.25e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544954659 165 ERVEMVEALAHDLKSPLSIILGYTDALIgnNTDDNEKLHRYLTVIRENTEKSAALVQKMQYTSDLE 230
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLR--DEKLDEEQREYLETILRSAERLLRLINDLLDLSRIE 64
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
165-230 |
2.80e-07 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 47.18 E-value: 2.80e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544954659 165 ERVEMVEALAHDLKSPLSIILGYTDALIgnNTDDNEKLHRYLTVIRENTEKSAALVQKMQYTSDLE 230
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLL--DTELSEEQREYLETILREAERLLRLINDLLDLSRIE 64
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
284-381 |
6.29e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 47.42 E-value: 6.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 284 LTRIFDNIISNSLQYTPSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYrgdearQTK--GGHSGLGLYIVK 361
Cdd:cd16943 4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF------TTKpvGEGTGLGLSLSY 77
|
90 100
....*....|....*....|
gi 544954659 362 QLVEQLGGSVKIENSKSGGA 381
Cdd:cd16943 78 RIIQKHGGTIRVASVPGGGT 97
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
109-152 |
6.71e-07 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 45.51 E-value: 6.71e-07
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 544954659 109 QPLHLLIDASKKIKEKDLDFEIDYYSDNELGKLCSAFSEMKDEL 152
Cdd:cd06225 2 RPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
105-157 |
9.24e-07 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 45.32 E-value: 9.24e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 544954659 105 KNINQPLHLLIDASKKIKEKDLDFEIDYYSDNELGKLCSAFSEMKDELKGSLS 157
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
290-385 |
1.14e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 46.62 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 290 NIISNSL----QYTPSGGNISITV-KDEKNCISYEICDSGRGFSSKDLKKALDKFYrgdearQTKGGHSGLGLYIVKQLV 364
Cdd:cd16920 7 NLVRNGIeamsEGGCERRELTIRTsPADDRAVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLSICRSII 80
|
90 100
....*....|....*....|.
gi 544954659 365 EQLGGSVKIENSKSGGACVKF 385
Cdd:cd16920 81 EAHGGRLSVESPAGGGATFQF 101
|
|
| HAMP |
pfam00672 |
HAMP domain; |
102-153 |
1.18e-06 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 45.31 E-value: 1.18e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 544954659 102 RFVKNINQPLHLLIDASKKIKEKDLDFEIDYYSDNELGKLCSAFSEMKDELK 153
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLR 52
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
54-157 |
4.18e-06 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 48.86 E-value: 4.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 54 KIEGAVILFYQVKITFANIRGRFVFAVIIMALFSPFLYIVGFTRWLSKRFVKNINQPLHLLIDASKKIKEKDLDFEIDYY 133
Cdd:COG0840 153 LAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVD 232
|
90 100
....*....|....*....|....
gi 544954659 134 SDNELGKLCSAFSEMKDELKGSLS 157
Cdd:COG0840 233 SKDEIGQLADAFNRMIENLRELVG 256
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
161-379 |
4.76e-06 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 48.78 E-value: 4.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 161 KMEQERVEMVEALAHDLKSPLSIILGYTDALigNNTDDNEKLHRYLTVIRENTEKSAALVQKMQYTSDLEKSNIQLNLVP 240
Cdd:PRK10618 445 KNQQARKAFLQNIGDELKQPLQSLAQLAAQL--RQTSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQEL 522
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 241 INLPEFLRQKVQDYELQAHQKEVELILKMQGNIQSPIQIDVDRLTRIfdniISNSLQY---TPSGGNISITV---KDEKN 314
Cdd:PRK10618 523 FSLQDLIDEVLPEVLPAIKRKGLQLLIHNHLKAEQLRIGDRDALRKI----LLLLLNYaitTTAYGKITLEVdqdESSPD 598
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544954659 315 CISYEICDSGRGFSSKD--------LKKAL-DKFYRGdearqtkgghSGLGLYIVKQLVEQLGGSVKIeNSKSG 379
Cdd:PRK10618 599 RLTIRILDTGAGVSIKEldnlhfpfLNQTQgDRYGKA----------SGLTFFLCNQLCRKLGGHLTI-KSREG 661
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
63-152 |
8.05e-06 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 47.93 E-value: 8.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 63 YQVKIT-FANIRGRFVFA--------VIIMALFSPF-----LYIVGFTRWLSKRFVKninQPLHLLIDASKKIKEKDLDF 128
Cdd:PRK10935 121 YQANIAnYVDQIDLFVLAlqhfaerkLILLAAISLLgliliLTLVFFTVRFTRRQVV---APLNQLVTASQQIEKGQFDH 197
|
90 100
....*....|....*....|....*
gi 544954659 129 -EIDYYSDNELGKLCSAFSEMKDEL 152
Cdd:PRK10935 198 iPLDTTLPNELGLLAKAFNQMSSEL 222
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
168-374 |
1.19e-05 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 47.00 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 168 EMVEALAHDLKSPLSIILGYTDALIGNNTDdnEKLHRYLTVIRENTEKSAALVQKM---QYTSDLEKSNIQL------NL 238
Cdd:PRK11073 132 DLVRGLAHEIKNPLGGLRGAAQLLSKALPD--PALTEYTKVIIEQADRLRNLVDRLlgpQRPGTHVTESIHKvaervvQL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 239 VPINLPEFLRQkVQDYElqahqkevelilkmqgniqsP----IQIDVDRLTRIFDNIISNSLQ-YTPSGGNISI---TV- 309
Cdd:PRK11073 210 VSLELPDNVRL-IRDYD--------------------PslpeLAHDPDQIEQVLLNIVRNALQaLGPEGGTITLrtrTAf 268
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 544954659 310 ------KDEKNCISYEICDSGRGFSSKdLKKALdkFYRGDEARQtkgGHSGLGLYIVKQLVEQLGGsvKIE 374
Cdd:PRK11073 269 qltlhgERYRLAARIDIEDNGPGIPPH-LQDTL--FYPMVSGRE---GGTGLGLSIARNLIDQHSG--KIE 331
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
165-385 |
1.39e-05 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 47.36 E-value: 1.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 165 ERVEMVEALAHDLKSPLSII--LGYTDAlignntddnEKLH--RYLTVIRENTEK--SAALVQKMQYTSDleksniqlNL 238
Cdd:PRK13560 604 EKEVLLKEIHHRVKNNLQIIssLLDLQA---------EKLHdeEAKCAFAESQDRicAMALAHEKLYQSE--------DL 666
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 239 VPINLPEFLRQkvqdyeLQAHQKEVELIlkMQGNIQSPIQ-----IDVDRLTR---IFDNIISNSLQYT-PSG--GNISI 307
Cdd:PRK13560 667 ADIDFLDYIES------LTAHLKNSFAI--DFGRIDCKIDaddgcLDIDKAIPcglIISELLSNALKHAfPDGaaGNIKV 738
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544954659 308 TVKDEKN-CISYEICDSGRGfsskdLKKALDkfYRGDEArqtkgghsgLGLYIVKQLVEQLGGSVKIENSKSGGACVKF 385
Cdd:PRK13560 739 EIREQGDgMVNLCVADDGIG-----LPAGFD--FRAAET---------LGLQLVCALVKQLDGEIALDSRGGARFNIRF 801
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
291-385 |
3.05e-05 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 43.36 E-value: 3.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 291 IISNSLQYT---PSGGNISITVKDEKNCISYEICDSGRGFSSKDLKKALDkfyrgDEARqtkgghSGLGLYIVKQLVEQL 367
Cdd:COG2172 42 AVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYS-----TLAE------GGRGLFLIRRLMDEV 110
|
90
....*....|....*...
gi 544954659 368 GgsvkIEnSKSGGACVKF 385
Cdd:COG2172 111 E----YE-SDPGGTTVRL 123
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
276-374 |
7.28e-05 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 44.96 E-value: 7.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 276 PIQIDVD--RLTRIFDNIISNSLQYTPSGGnISITVKDEKNCISYEICDSGRGFSSKDLKKALDKFYRGDEARQTKGGHS 353
Cdd:PRK10841 553 PVALNGDpmRLQQVISNLLSNAIKFTDTGC-IVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGT 631
|
90 100
....*....|....*....|.
gi 544954659 354 GLGLYIVKQLVEQLGGSVKIE 374
Cdd:PRK10841 632 GLGLAICEKLINMMDGDISVD 652
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
260-380 |
8.81e-05 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 44.44 E-value: 8.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 260 QKEVELILKMqgNI-------QSPIQIDVDRLTRIFDNIISNSLQY---TPSGGN-ISITVKDEKNCISYEICDSGRGFS 328
Cdd:PRK15053 404 QRARELGLKM--VIvpgsqlsQLPPGLDSTEFAAIVGNLLDNAFEAslrSDEGNKiVELFLSDEGDDVVIEVADQGCGVP 481
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 544954659 329 SKdLKKALdkFYRGDEARQTKGGHSGLGLYIVKQLVEQLGGSVKIENSKSGG 380
Cdd:PRK15053 482 ES-LRDKI--FEQGVSTRADEPGEHGIGLYLIASYVTRCGGVITLEDNDPCG 530
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
163-386 |
1.98e-04 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 42.68 E-value: 1.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 163 EQERvemvEALA---HD-LKSPLSIILGYTDALIGNNTDDNEKLHRYLTVIRENTEKSAALVQKMqyTSDLEksniQLNL 238
Cdd:COG4585 51 EEER----RRIArelHDgVGQSLSAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRL--VRGLR----PPAL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 239 VPINLPEFLRQKVQDYELQAHqkeVELILKMQGNIqSPIQIDVDR-LTRIFDNIISNSLQYTPsGGNISITVKDEKNCIS 317
Cdd:COG4585 121 DDLGLAAALEELAERLLRAAG---IRVELDVDGDP-DRLPPEVELaLYRIVQEALTNALKHAG-ATRVTVTLEVDDGELT 195
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544954659 318 YEICDSGRGFsskdlkkaldkfyrgDEARQTKGGHsglGLYIVKQLVEQLGGSVKIENSKSGGACVKFW 386
Cdd:COG4585 196 LTVRDDGVGF---------------DPEAAPGGGL---GLRGMRERAEALGGTLTIGSAPGGGTRVRAT 246
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
259-379 |
4.74e-04 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 40.64 E-value: 4.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 259 HQKEVELIlkMQGniqSPIQIDVDRLTRIFD---NIISNSLQY------------TPSGGNISITVKDEKNCISYEICDS 323
Cdd:cd16916 16 LGKQVELV--VEG---EDTELDKSVLEKLADpltHLLRNAVDHgieapeerlaagKPPEGTITLRAEHQGNQVVIEVSDD 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544954659 324 GRGFS-SKDLKKALDKFYRGDEARQT-----------KGGHS-----------GLGLYIVKQLVEQLGGSVKIEnSKSG 379
Cdd:cd16916 91 GRGIDrEKIREKAIERGLITADEAATlsddevlnlifAPGFStaeqvtdvsgrGVGMDVVKRSIESLGGTIEVE-SEPG 168
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-385 |
1.16e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 38.21 E-value: 1.16e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544954659 322 DSGRGFSSKDLKKALDKFYrgdearQTK--GGHSGLGLYIVKQLVEQLGGSVKIENSKSGGACVKF 385
Cdd:cd16976 41 DNGPGIAEEHLSRVFDPFF------TTKpvGKGTGLGLSISYGIVEEHGGRLSVANEEGAGARFTF 100
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
292-368 |
1.28e-03 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 37.63 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 292 ISNSLQYT---PSGGNISITVKDEKNCISYEICDSGRGFsskDLKKALDKfyrgDEARQTkgghSGLGLYIVKQLVEQLG 368
Cdd:cd16936 9 VTNAVRHAyrhDGPGPVRLELDLDPDRLRVEVTDSGPGF---DPLRPADP----DAGLRE----GGRGLALIRALMDEVG 77
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|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
301-365 |
2.90e-03 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 37.65 E-value: 2.90e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544954659 301 SGGNISITVKDEKNCISYEICDSGRGFsskDLKKALDkfyRGDEARQTKGGHSGLGLYIVKQLVE 365
Cdd:pfam13581 52 PEGPVEVRLTSDGGGLVVTVADSGPPF---DPLTLPP---PDLEEPDEDRKEGGRGLALIRGLMD 110
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
251-375 |
3.78e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 37.17 E-value: 3.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 251 VQDYELQAHQKEVELILKMQGNIQSPIQiDVDrLTRIFDNIISNSL---QYTPSGGN-ISITVKDEKNCISYEI------ 320
Cdd:cd16935 6 LSEKLELAREKGIEFTIEIDIPILLPIS-PLD-LCIIFGNLLDNAIeacAKIDKENRfIHLKIRQKKGFLIISIensyeg 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 544954659 321 ---CDSGRGFSSKdlkkaldkfyrgdearqtKGGHSGLGLYIVKQLVEQLGGSVKIEN 375
Cdd:cd16935 84 elkKKNGLFLSTK------------------KDKNHGIGLKSIREIVKKYNGNLSIEY 123
|
|
| COG3292 |
COG3292 |
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; |
5-292 |
6.22e-03 |
|
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
Pssm-ID: 442521 [Multi-domain] Cd Length: 924 Bit Score: 38.82 E-value: 6.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 5 VVDNNGNILYGTNPKKLFKTKEELFNNFINKTVRKGGYIHTVPIKGDNGKIEGAVILFYQVKITFANIRGRFVFAVIIMA 84
Cdd:COG3292 454 LEDDNGNLWNFNSASNLGLLSLLGGLLGGLNLGNAIKLPLSNLGLLLTLLLLGINLSLVRSLISLLTLLLLALLLLLSLL 533
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 85 LFSPFLYIVGFTRWLSKRFVKNINQPLHLLIDASKKIKEKDLDFEIDYYSDNELGKLCSAFSEMKDELKGSLSAQWKMEQ 164
Cdd:COG3292 534 LLLLLLLLLLLLLLLLLLLLLLLILLLLLLRLLLLLLLLELLERLLALLLEIELLLTLLLLLLLLLLLLLLLLILLLLLL 613
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544954659 165 ERVEMVEALAHDLKSPLSIILGYTDALIGNNTDDNEKLHRYLTVIRENTEKSAALVQKMQYTSDLEKSNIQLNLVPINLP 244
Cdd:COG3292 614 LLLLLLILLLLLLLLLLLLILLLLLLLLLLLLLLLLRLLLELLLLELELLLELLLLLAELILELLLILLLLLLLLLLALL 693
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 544954659 245 EFLRQKVQDYELQAHQKEVELILKMQGNIQSPIQIDVDRLTRIFDNII 292
Cdd:COG3292 694 LLLLLLLALKLLLLLLLILLLLLLLLGLLLLLLDLVLLLLLLILLIIL 741
|
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| |
