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Conserved domains on  [gi|544960038|ref|WP_021364773|]
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tagatose-bisphosphate aldolase subunit GatY [Clostridioides difficile]

Protein Classification

beta/alpha barrel domain-containing protein( domain architecture ID 229392)

beta/alpha barrel domain-containing protein belongs to a large superfamily with a wide variety of enzymatic functions

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
TIM super family cl21457
TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate ...
 1-283 8.59e-169

TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate isomerase (TIM) which, in general, share an eight beta/alpha closed barrel structure.


The actual alignment was detected with superfamily member PRK09195:

Pssm-ID: 473867  Cd Length: 284  Bit Score: 468.84  E-value: 8.59e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMH 80
Cdd:PRK09195   1 MYLVSTKQMLNNAQRGGYAVPAFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSYAGTEYLLAIVSAAAKQYHHPLALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  81 LDHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGA-YTDPLEA 159
Cdd:PRK09195  81 LDHHEKFDDIAQKVRSGVRSVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQEDDLQVDEADAlYTDPAQA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 160 KEFVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYS 239
Cdd:PRK09195 161 REFVEATGIDSLAVAIGTAHGMYKGEPKLDFDRLENIRQWVNIPLVLHGASGLPTKDIQQTIKLGICKVNVATELKIAFS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 544960038 240 NGVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:PRK09195 241 QALKNYLTEHPEANDPRHYLQPAKSAMKDVVSKVIADCGCEGKA 284
 
Name Accession Description Interval E-value
gatY PRK09195
tagatose-bisphosphate aldolase; Reviewed
 1-283 8.59e-169

tagatose-bisphosphate aldolase; Reviewed


Pssm-ID: 181690  Cd Length: 284  Bit Score: 468.84  E-value: 8.59e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMH 80
Cdd:PRK09195   1 MYLVSTKQMLNNAQRGGYAVPAFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSYAGTEYLLAIVSAAAKQYHHPLALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  81 LDHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGA-YTDPLEA 159
Cdd:PRK09195  81 LDHHEKFDDIAQKVRSGVRSVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQEDDLQVDEADAlYTDPAQA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 160 KEFVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYS 239
Cdd:PRK09195 161 REFVEATGIDSLAVAIGTAHGMYKGEPKLDFDRLENIRQWVNIPLVLHGASGLPTKDIQQTIKLGICKVNVATELKIAFS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 544960038 240 NGVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:PRK09195 241 QALKNYLTEHPEANDPRHYLQPAKSAMKDVVSKVIADCGCEGKA 284
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 2-283 3.83e-150

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 421.42  E-value: 3.83e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   2 ALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMHL 81
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASVPVALHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  82 DHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGK-EDDLDGGDGGAYTDPLEAK 160
Cdd:COG0191   81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEeDGVDVDDAEALYTDPEEAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 161 EFVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYSN 240
Cdd:COG0191  161 EFVEETGVDALAVAIGTVHGVYKGEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAFTA 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 544960038 241 GVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:COG0191  241 AVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIRLFGSAGKA 283
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
4-282 1.34e-138

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 391.78  E-value: 1.34e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038    4 VTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKY--AGLDYYLANVKVASEKASVPVAMHL 81
Cdd:pfam01116   1 VNLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKyaGGAEALAALVRAAAEAAGVPVALHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   82 DHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGgAYTDPLEAKE 161
Cdd:pfam01116  81 DHGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEEDGVVVDEK-LYTDPEEAAE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  162 FVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYSNG 241
Cdd:pfam01116 160 FVEATGVDALAVAIGNVHGVYKPGPKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTAA 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 544960038  242 VKDVlnsdPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGK 282
Cdd:pfam01116 240 VREY----PPNKDPRKYLRPAEEAMKEVVKEKIRLFGSAGK 276
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 6-281 2.96e-132

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 375.71  E-value: 2.96e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   6 TKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMHLDHGS 85
Cdd:cd00947    1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERASVPVALHLDHGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  86 SFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVgGKEDDLDGGDGGAYTDPLEAKEFVER 165
Cdd:cd00947   81 SFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRI-GGEEDGVVGDEGLLTDPEEAEEFVEE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 166 TGVSSLAVAIGTAHGLYKG-EPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYSNGVKD 244
Cdd:cd00947  160 TGVDALAVAIGTSHGAYKGgEPKLDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAALRE 239

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 544960038 245 VLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVG 281
Cdd:cd00947  240 YLAENPKEFDPRKYLAPAIEAVKEVVKHKMELFGSAG 276
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 1-283 1.26e-117

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 339.29  E-value: 1.26e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038    1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKY-AGLDYYLANVKVASEKAS--VPV 77
Cdd:TIGR00167   1 MMLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYiAGLGAISAMVKAMSEAYPygVPV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   78 AMHLDHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGA-YTDP 156
Cdd:TIGR00167  81 ALHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGVSVADESAlYTDP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  157 LEAKEFVERTGVSSLAVAIGTAHGLYKGEPK-LDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELR 235
Cdd:TIGR00167 161 EEAKEFVKLTGVDSLAAAIGNVHGVYKGEPKgLDFERLEEIQKYVNLPLVLHGGSGIPDEEIKKAISLGVVKVNIDTELQ 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 544960038  236 IAYSNGVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:TIGR00167 241 IAFAAAVRNYYAENKDYYDPRVWLRPGEKAMKEVVLEKIKLFGSANKA 288
 
Name Accession Description Interval E-value
gatY PRK09195
tagatose-bisphosphate aldolase; Reviewed
 1-283 8.59e-169

tagatose-bisphosphate aldolase; Reviewed


Pssm-ID: 181690  Cd Length: 284  Bit Score: 468.84  E-value: 8.59e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMH 80
Cdd:PRK09195   1 MYLVSTKQMLNNAQRGGYAVPAFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSYAGTEYLLAIVSAAAKQYHHPLALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  81 LDHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGA-YTDPLEA 159
Cdd:PRK09195  81 LDHHEKFDDIAQKVRSGVRSVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQEDDLQVDEADAlYTDPAQA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 160 KEFVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYS 239
Cdd:PRK09195 161 REFVEATGIDSLAVAIGTAHGMYKGEPKLDFDRLENIRQWVNIPLVLHGASGLPTKDIQQTIKLGICKVNVATELKIAFS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 544960038 240 NGVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:PRK09195 241 QALKNYLTEHPEANDPRHYLQPAKSAMKDVVSKVIADCGCEGKA 284
gatY PRK12737
tagatose-bisphosphate aldolase subunit GatY;
1-283 1.77e-150

tagatose-bisphosphate aldolase subunit GatY;


Pssm-ID: 183710  Cd Length: 284  Bit Score: 422.18  E-value: 1.77e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMH 80
Cdd:PRK12737   1 MYIISTKNMLKKAQAEGYAVPAFNIHNLETLQVVVETAAELRSPVILAGTPGTFSYAGTDYIVAIAEVAARKYNIPLALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  81 LDHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGA-YTDPLEA 159
Cdd:PRK12737  81 LDHHEDLDDIKKKVRAGIRSVMIDGSHLSFEENIAIVKEVVEFCHRYDASVEAELGRLGGQEDDLVVDEKDAmYTNPDAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 160 KEFVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYS 239
Cdd:PRK12737 161 AEFVERTGIDSLAVAIGTAHGLYKGEPKLDFERLAEIREKVSIPLVLHGASGVPDEDVKKAISLGICKVNVATELKIAFS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 544960038 240 NGVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:PRK12737 241 DAVKKYFYENPKANDPRKYMTPGKAAMKEVVREKIKVCGSEGKL 284
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 2-283 3.83e-150

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 421.42  E-value: 3.83e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   2 ALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMHL 81
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASVPVALHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  82 DHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGK-EDDLDGGDGGAYTDPLEAK 160
Cdd:COG0191   81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEeDGVDVDDAEALYTDPEEAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 161 EFVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYSN 240
Cdd:COG0191  161 EFVEETGVDALAVAIGTVHGVYKGEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAFTA 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 544960038 241 GVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:COG0191  241 AVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIRLFGSAGKA 283
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
4-282 1.34e-138

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 391.78  E-value: 1.34e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038    4 VTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKY--AGLDYYLANVKVASEKASVPVAMHL 81
Cdd:pfam01116   1 VNLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKyaGGAEALAALVRAAAEAAGVPVALHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   82 DHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGgAYTDPLEAKE 161
Cdd:pfam01116  81 DHGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEEDGVVVDEK-LYTDPEEAAE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  162 FVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYSNG 241
Cdd:pfam01116 160 FVEATGVDALAVAIGNVHGVYKPGPKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTAA 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 544960038  242 VKDVlnsdPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGK 282
Cdd:pfam01116 240 VREY----PPNKDPRKYLRPAEEAMKEVVKEKIRLFGSAGK 276
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 6-281 2.96e-132

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 375.71  E-value: 2.96e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   6 TKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMHLDHGS 85
Cdd:cd00947    1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERASVPVALHLDHGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  86 SFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVgGKEDDLDGGDGGAYTDPLEAKEFVER 165
Cdd:cd00947   81 SFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRI-GGEEDGVVGDEGLLTDPEEAEEFVEE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 166 TGVSSLAVAIGTAHGLYKG-EPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYSNGVKD 244
Cdd:cd00947  160 TGVDALAVAIGTSHGAYKGgEPKLDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAALRE 239

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 544960038 245 VLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVG 281
Cdd:cd00947  240 YLAENPKEFDPRKYLAPAIEAVKEVVKHKMELFGSAG 276
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
1-283 5.59e-119

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 342.48  E-value: 5.59e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMH 80
Cdd:PRK12857   1 MMLVTVAELLKKAEKGGYAVGAFNCNNMEIVQAIVAAAEAEKSPVIIQASQGAIKYAGIEYISAMVRTAAEKASVPVALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  81 LDHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGA-YTDPLEA 159
Cdd:PRK12857  81 LDHGTDFEQVMKCIRNGFTSVMIDGSKLPLEENIALTKKVVEIAHAVGVSVEAELGKIGGTEDDITVDEREAaMTDPEEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 160 KEFVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYS 239
Cdd:PRK12857 161 RRFVEETGVDALAIAIGTAHGPYKGEPKLDFDRLAKIKELVNIPIVLHGSSGVPDEAIRKAISLGVRKVNIDTNIREAFV 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 544960038 240 NGVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:PRK12857 241 ARLREVLEKNPDEIDPRKILGPAREAAKEVIREKIRLFGSAGKA 284
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 1-283 1.26e-117

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 339.29  E-value: 1.26e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038    1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKY-AGLDYYLANVKVASEKAS--VPV 77
Cdd:TIGR00167   1 MMLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYiAGLGAISAMVKAMSEAYPygVPV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   78 AMHLDHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGA-YTDP 156
Cdd:TIGR00167  81 ALHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGVSVADESAlYTDP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  157 LEAKEFVERTGVSSLAVAIGTAHGLYKGEPK-LDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELR 235
Cdd:TIGR00167 161 EEAKEFVKLTGVDSLAAAIGNVHGVYKGEPKgLDFERLEEIQKYVNLPLVLHGGSGIPDEEIKKAISLGVVKVNIDTELQ 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 544960038  236 IAYSNGVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:TIGR00167 241 IAFAAAVRNYYAENKDYYDPRVWLRPGEKAMKEVVLEKIKLFGSANKA 288
tag_bisphos_ald TIGR01858
class II aldolase, tagatose bisphosphate family; This model describes tagatose-1, ...
 3-283 5.83e-114

class II aldolase, tagatose bisphosphate family; This model describes tagatose-1,6-bisphosphate aldolases, and perhaps other closely related class II aldolases. This tetrameric, Zn2+-dependent enzyme is related to the class II fructose bisphosphate aldolase; fructose 1,6-bisphosphate and tagatose 1,6 bisphosphate differ only in chirality at C4.


Pssm-ID: 130917  Cd Length: 282  Bit Score: 329.90  E-value: 5.83e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038    3 LVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMHLD 82
Cdd:TIGR01858   1 IVSTKYMLQDAQAGGYAVPAFNIHNLETIQAVVETAAEMRSPVILAGTPGTFKHAGTEYIVALCSAASTTYNMPLALHLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   83 HGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGA-YTDPLEAKE 161
Cdd:TIGR01858  81 HHESLDDIRQKVHAGVRSAMIDGSHFPFAQNVKLVKEVVDFCHRQDCSVEAELGRLGGVEDDLSVDEEDAlYTDPQEAKE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  162 FVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYSNG 241
Cdd:TIGR01858 161 FVEATGVDSLAVAIGTAHGLYKKTPKLDFDRLAEIREVVDVPLVLHGASDVPDEDVRRTIELGICKVNVATELKIAFSGA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 544960038  242 VKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:TIGR01858 241 VKAYFAENPQANDPRYYMRPGKDAMKKVVRNKINVCGSAGRA 282
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 3-283 4.15e-110

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 320.08  E-value: 4.15e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038    3 LVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAG-LDYYLANVKVASEKAS-VPVAMH 80
Cdd:TIGR01859   1 LVNGKEILQKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGgYKMAVAMVKTLIERMSiVPVALH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   81 LDHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGaYTDPLEAK 160
Cdd:TIGR01859  81 LDHGSSYESCIKAIKAGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGIEDGVDEKEAE-LADPDEAE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  161 EFVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYSN 240
Cdd:TIGR01859 160 QFVKETGVDYLAAAIGTSHGKYKGEPGLDFERLKEIKELTNIPLVLHGASGIPEEQIKKAIKLGIAKINIDTDCRIAFTA 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 544960038  241 GVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:TIGR01859 240 AIRKVLTEKKDEYDPRKILGPAREAIKETVKEKMRLFGSAGKA 282
kbaY PRK12738
tagatose-bisphosphate aldolase subunit KbaY;
1-282 1.36e-99

tagatose-bisphosphate aldolase subunit KbaY;


Pssm-ID: 183711  Cd Length: 286  Bit Score: 293.48  E-value: 1.36e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMH 80
Cdd:PRK12738   1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  81 LDHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGAY-TDPLEA 159
Cdd:PRK12738  81 LDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFlTDPQEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 160 KEFVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYS 239
Cdd:PRK12738 161 KRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFA 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 544960038 240 NGVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGK 282
Cdd:PRK12738 241 GAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANR 283
PRK08185 PRK08185
hypothetical protein; Provisional
 7-283 2.27e-95

hypothetical protein; Provisional


Pssm-ID: 181275  Cd Length: 283  Bit Score: 282.77  E-value: 2.27e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   7 KQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGlDYYLANVKVASEKASVPVAMHLDHGSS 86
Cdd:PRK08185   2 KELLKVAKEHQFAVGAFNVADSCFLRAVVEEAEANNAPAIIAIHPNELDFLG-DNFFAYVRERAKRSPVPFVIHLDHGAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  87 FGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKV-GGKEDDLDGGDGGAYTDPLEAKEFVER 165
Cdd:PRK08185  81 IEDVMRAIRCGFTSVMIDGSLLPYEENVALTKEVVELAHKVGVSVEGELGTIgNTGTSIEGGVSEIIYTDPEQAEDFVSR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 166 TGVSSLAVAIGTAHGLYK--GEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYSNGVK 243
Cdd:PRK08185 161 TGVDTLAVAIGTAHGIYPkdKKPELQMDLLKEINERVDIPLVLHGGSANPDAEIAESVQLGVGKINISSDMKYAFFKKVR 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 544960038 244 DVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:PRK08185 241 EILSDNPSLYEPNQIYPSAIEAAKEVVRHKMDLFNSTGKA 280
PRK06806 PRK06806
class II aldolase;
1-283 5.03e-86

class II aldolase;


Pssm-ID: 180705  Cd Length: 281  Bit Score: 258.92  E-value: 5.03e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMH 80
Cdd:PRK06806   1 MPLVQMKELLKKANQENYGVGAFSVANMEMVMGAIKAAEELNSPIILQIAEVRLNHSPLHLIGPLMVAAAKQAKVPVAVH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  81 LDHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGaYTDPLEAK 160
Cdd:PRK06806  81 FDHGMTFEKIKEALEIGFTSVMFDGSHLPLEENIQKTKEIVELAKQYGATVEAEIGRVGGSEDGSEDIEML-LTSTTEAK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 161 EFVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATelriAYSN 240
Cdd:PRK06806 160 RFAEETDVDALAVAIGNAHGMYNGDPNLRFDRLQEINDVVHIPLVLHGGSGISPEDFKKCIQHGIRKINVAT----ATFN 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 544960038 241 GVKDV---LNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:PRK06806 236 SVITAvnnLVLNTPYSDYFTYHQDVIKAAYENVKKHMQIFGSENKA 281
PRK08610 PRK08610
fructose-bisphosphate aldolase; Reviewed
 1-283 7.42e-84

fructose-bisphosphate aldolase; Reviewed


Pssm-ID: 181501  Cd Length: 286  Bit Score: 253.37  E-value: 7.42e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLDYYLANVK---VASEKASVPV 77
Cdd:PRK08610   1 MPLVSMKEMLIDAKENGYAVGQYNLNNLEFTQAILEASQEENAPVILGVSEGAARYMSGFYTVVKMVeglMHDLNITIPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  78 AMHLDHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGaYTDPL 157
Cdd:PRK08610  81 AIHLDHGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVGGQEDDVVADGII-YADPK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 158 EAKEFVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIA 237
Cdd:PRK08610 160 ECQELVEKTGIDALAPALGSVHGPYKGEPKLGFKEMEEIGLSTGLPLVLHGGTGIPTKDIQKAIPFGTAKINVNTENQIA 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 544960038 238 YSNGVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:PRK08610 240 SAKAVRDVLNNDKEVYDPRKYLGPAREAIKETVKGKIKEFGTSNRA 285
PRK05835 PRK05835
class II fructose-1,6-bisphosphate aldolase;
3-282 1.03e-82

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180280 [Multi-domain]  Cd Length: 307  Bit Score: 251.43  E-value: 1.03e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   3 LVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLDYYLANVKVASEK-ASVPVAMHL 81
Cdd:PRK05835   2 LVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERyPHIPVALHL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  82 DHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGA-YTDPLEAK 160
Cdd:PRK05835  82 DHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAvLVNPKEAE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 161 EFVERTGVSSLAVAIGTAHGL--YKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEV---------------------I 217
Cdd:PRK05835 162 QFVKESQVDYLAPAIGTSHGAfkFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDDVrksyldaggdlkgskgvpfefL 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544960038 218 KESIKRGICKVNYATELRIAYSNGVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGK 282
Cdd:PRK05835 242 QESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANK 306
PRK07709 PRK07709
fructose-bisphosphate aldolase; Provisional
 1-283 3.04e-80

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 169068  Cd Length: 285  Bit Score: 244.19  E-value: 3.04e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKY-AGLDYYLANVKVASEKA--SVPV 77
Cdd:PRK07709   1 MPLVSMKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHmTGFKTVVAMVKALIEEMniTVPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  78 AMHLDHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGaYTDPL 157
Cdd:PRK07709  81 AIHLDHGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVGGQEDDVIAEGVI-YADPA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 158 EAKEFVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIA 237
Cdd:PRK07709 160 ECKHLVEATGIDCLAPALGSVHGPYKGEPNLGFAEMEQVRDFTGVPLVLHGGTGIPTADIEKAISLGTSKINVNTENQIE 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 544960038 238 YSNGVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:PRK07709 240 FTKAVREVLNKDQEVYDPRKFIGPGRDAIKATVIGKIREFGSNGKA 285
PRK06801 PRK06801
ketose 1,6-bisphosphate aldolase;
1-283 5.91e-80

ketose 1,6-bisphosphate aldolase;


Pssm-ID: 180701  Cd Length: 286  Bit Score: 243.50  E-value: 5.91e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMH 80
Cdd:PRK06801   1 MALISLANGLAHARKHGYALGAFNVLDSHFLRALFAAAKQERSPFIINIAEVHFKYISLESLVEAVKFEAARHDIPVVLN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  81 LDHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKV--GGKEDDLDGGDGGAYTDPLE 158
Cdd:PRK06801  81 LDHGLHFEAVVRALRLGFSSVMFDGSTLEYEENVRQTREVVKMCHAVGVSVEAELGAVggDEGGALYGEADSAKFTDPQL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 159 AKEFVERTGVSSLAVAIGTAHGLYKGEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAY 238
Cdd:PRK06801 161 ARDFVDRTGIDALAVAIGNAHGKYKGEPKLDFARLAAIHQQTGLPLVLHGGSGISDADFRRAIELGIHKINFYTGMSQAA 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 544960038 239 SNGVKDVLNSDPEVIDPKKYGKKGLE-SVKDFVKSRMEVCGCVGKA 283
Cdd:PRK06801 241 LAAVEQRMTHRHAIYDEFAELLLGIEeAISDTVAQQMRIFGSAGQA 286
gatY PRK07998
class II aldolase;
1-276 4.27e-76

class II aldolase;


Pssm-ID: 181192  Cd Length: 283  Bit Score: 233.50  E-value: 4.27e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLDYYLANVKVASEKASVPVAMH 80
Cdd:PRK07998   1 MPLVNGRILLDRIQEKHVLAGAFNTTNLETTISILNAIERSGLPNFIQIAPTNAQLSGYDYIYEIVKRHADKMDVPVSLH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  81 LDHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVgGKEDDLDGGDGGAYTDPLEAK 160
Cdd:PRK07998  81 LDHGKTFEDVKQAVRAGFTSVMIDGAALPFEENIAFTKEAVDFAKSYGVPVEAELGAI-LGKEDDHVSEADCKTEPEKVK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 161 EFVERTGVSSLAVAIGTAHGLYKgEPKLDLDRLSEIREVVSVPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYSN 240
Cdd:PRK07998 160 DFVERTGCDMLAVSIGNVHGLED-IPRIDIPLLKRIAEVSPVPLVIHGGSGIPPEILRSFVNYKVAKVNIASDLRKAFIT 238

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 544960038 241 GVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSRMEV 276
Cdd:PRK07998 239 TVGKAYVNNHNEANLARVMAKAKQAVEEDVYSKIKM 274
PRK07084 PRK07084
class II fructose-1,6-bisphosphate aldolase;
1-283 5.72e-70

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180829  Cd Length: 321  Bit Score: 219.21  E-value: 5.72e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAG--LDYYLANVKVASEK---ASV 75
Cdd:PRK07084   7 LGLVNTREMFAKAVKGGYAIPAYNFNNMEQLQAIIQACVETKSPVILQVSKGARKYANatLLRYMAQGAVEYAKelgCPI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  76 PVAMHLDHGSSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGkVGGKEDDLDGGDGGAYTD 155
Cdd:PRK07084  87 PIVLHLDHGDSFELCKDCIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELG-VLAGVEDEVSAEHHTYTQ 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 156 PLEAKEFVERTGVSSLAVAIGTAHGLYK---GE--PKLDLDRLSEI-REVVSVPLVLHGGS------------------- 210
Cdd:PRK07084 166 PEEVEDFVKKTGVDSLAISIGTSHGAYKfkpGQcpPPLRFDILEEIeKRIPGFPIVLHGSSsvpqeyvktineyggklkd 245

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544960038 211 --GIPDEVIKESIKRGICKVNYATELRIAYSNGVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSR-MEVCGCVGKA 283
Cdd:PRK07084 246 aiGIPEEQLRKAAKSAVCKINIDSDGRLAMTAAIRKVFDEKPEEFDPRKYLGPARDELKKLYKHKiINVLGSNGKA 321
PRK09196 PRK09196
fructose-bisphosphate aldolase class II;
1-286 1.02e-69

fructose-bisphosphate aldolase class II;


Pssm-ID: 181691  Cd Length: 347  Bit Score: 219.44  E-value: 1.02e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGlDYYLANVKVASEKA--SVPVA 78
Cdd:PRK09196   1 MALISLRQLLDHAAEHGYGVPAFNVNNLEQVQAIMEAADETDSPVILQASAGARKYAG-EPFLRHLILAAVEEypHIPVV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  79 MHLDHGSSFGLAMQALRVGYTSIMIDGSHE-------SYEDNISISKSVVDACMPSDIPVEAELG-----------KVGG 140
Cdd:PRK09196  80 MHQDHGNSPATCQRAIQLGFTSVMMDGSLKadgktpaSYEYNVDVTRKVVEMAHACGVSVEGELGclgsletgmggEEDG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 141 KEDDLDGGDGGAYTDPLEAKEFVERTGVSSLAVAIGTAHGLYKGEPK-----LDLDRLSEI-REVVSVPLVLHGGS---- 210
Cdd:PRK09196 160 HGAEGKLSHDQLLTDPEEAADFVKKTQVDALAIAIGTSHGAYKFTRKptgdvLAIDRIKEIhARLPNTHLVMHGSSsvpq 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 211 -----------------GIPDEVIKESIKRGICKVNYATELRIAYSNGVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSR 273
Cdd:PRK09196 240 elldiineyggdmpetyGVPVEEIQEGIKHGVRKVNIDTDLRLAMTGAIRRFLAENPSEFDPRKYLKPAMEAMKKICKAR 319

                        330
                 ....*....|...
gi 544960038 274 MEVCGCVGKAIEI 286
Cdd:PRK09196 320 YEAFGTAGQASKI 332
PRK13399 PRK13399
fructose-bisphosphate aldolase class II;
1-286 1.35e-65

fructose-bisphosphate aldolase class II;


Pssm-ID: 184029  Cd Length: 347  Bit Score: 208.87  E-value: 1.35e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGlDYYLANVKVASEKA--SVPVA 78
Cdd:PRK13399   1 MALITLRQLLDHAAENGYGVPAFNVNNMEQILAIMEAAEATDSPVILQASRGARKYAG-DAMLRHMVLAAAEMypDIPIC 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  79 MHLDHGSSFGLAMQALRVGYTSIMIDGSHE-------SYEDNISISKSVVDACMPSDIPVEAELG-----------KVGG 140
Cdd:PRK13399  80 LHQDHGNSPATCQSAIRSGFTSVMMDGSLLadgktpaSYDYNVDVTRRVTEMAHAVGVSVEGELGclgsletgeagEEDG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 141 KEDDLDGGDGGAYTDPLEAKEFVERTGVSSLAVAIGTAHGLYKGEPK-----LDLDRLSEI-REVVSVPLVLHGGS---- 210
Cdd:PRK13399 160 VGAEGKLSHDQMLTDPDQAVDFVQRTGVDALAIAIGTSHGAYKFTRKpdgdiLAIDRIEEIhARLPNTHLVMHGSSsvpq 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 211 -----------------GIPDEVIKESIKRGICKVNYATELRIAYSNGVKDVLNSDPEVIDPKKYGKKGLESVKDFVKSR 273
Cdd:PRK13399 240 elqeiinayggkmketyGVPVEEIQRGIKHGVRKVNIDTDIRLAMTGAIRKVLAEHPSEFDPRKALKPAMKAMTALCKQR 319

                        330
                 ....*....|...
gi 544960038 274 MEVCGCVGKAIEI 286
Cdd:PRK13399 320 FEAFGTAGQASKI 332
PLN02858 PLN02858
fructose-bisphosphate aldolase
 5-283 1.64e-64

fructose-bisphosphate aldolase


Pssm-ID: 215463 [Multi-domain]  Cd Length: 1378  Bit Score: 218.95  E-value: 1.64e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038    5 TTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGLdYYLANVKVASEKASVPVAMHLDHG 84
Cdd:PLN02858 1101 STKELLLNAEKGGYAVGAFNVYNLEGIEAVVAAAEAEKSPAILQVHPGALKQGGI-PLVSCCIAAAEQASVPITVHFDHG 1179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   85 SSFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGA-YTDPLEAKEFV 163
Cdd:PLN02858 1180 TSKHELLEALELGFDSVMVDGSHLSFTENISYTKSISSLAHSKGLMVEAELGRLSGTEDGLTVEEYEAkLTDVDQAKEFI 1259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  164 ERTGVSSLAVAIGTAHGLY-KGEPKLDLDRLSEIREVVS---VPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYS 239
Cdd:PLN02858 1260 DETGIDALAVCIGNVHGKYpASGPNLRLDLLKELRALSSkkgVLLVLHGASGLPESLIKECIENGVRKFNVNTEVRTAYM 1339

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 544960038  240 NGVkdvlnSDPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:PLN02858 1340 EAL-----SSPKKTDLIDVMSAAKEAMKAVVAEKLRLFGSAGKA 1378
FTBP_aldolase_II cd00453
Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1, ...
 6-280 1.78e-62

Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to yield fructose-1,6-bisphosphate. TBP-aldolase is tetrameric and produces tagarose-1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. Although structurally similar, the class I aldolases use a different mechanism and are believed to have an independent evolutionary origin.


Pssm-ID: 238255  Cd Length: 340  Bit Score: 200.42  E-value: 1.78e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   6 TKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPS-TIKYAG---------------LDYYLANVKVA 69
Cdd:cd00453    1 VQKVFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSNGgASFIAGkgvksdvpqgaailgAISGAHHVHQM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  70 SEKASVPVAMHLDHGSSFGL-------------AMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELG 136
Cdd:cd00453   81 AEHYGVPVILHTDHCAKKLLpwidglldagekhFAATGKPLFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 137 KVGGKEDDLDGGDGGA---YTDPLEAKEFVERTG----VSSLAVAIGTAHGLYK-GEPKLDLDRLSEIREVVS------- 201
Cdd:cd00453  161 CTGGEEDGVDNSHMDAsalYTQPEDVDYAYTELSkispRFTIAASFGNVHGVYKkGNVVLTPTILRDSQEYVSkkhnlph 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 202 --VPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYSNGVKDVLNSDPEVI------------------DPKKYGKK 261
Cdd:cd00453  241 nsLNFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVLNYYKANEAYLqgqlgnpkgedqpnkkyyDPRVWLRA 320

                        330
                 ....*....|....*....
gi 544960038 262 GLESVKDFVKSRMEVCGCV 280
Cdd:cd00453  321 GQTSMIARLEKAFQELNAI 339
PRK07315 PRK07315
fructose-bisphosphate aldolase; Provisional
 1-283 9.52e-60

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 180926  Cd Length: 293  Bit Score: 192.02  E-value: 9.52e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   1 MALVTTKQILLDAQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIKYAGlDYYLANVKVA----SEKASVP 76
Cdd:PRK07315   1 MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMG-GYKVCKNLIEnlveSMGITVP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  77 VAMHLDHGSsFGLAMQALRVGYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGKVGGKEDDLDGGDGGAYTDp 156
Cdd:PRK07315  80 VAIHLDHGH-YEDALECIEVGYTSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGIIGKGELAPIE- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 157 lEAKEFVErTGVSSLAVAIGTAHGLYKGEPK-LDLDRLSEIREVVS-VPLVLHGGSGIPDEVIKESIKRGICKVNYATEL 234
Cdd:PRK07315 158 -DAKAMVE-TGIDFLAAGIGNIHGPYPENWEgLDLDHLEKLTEAVPgFPIVLHGGSGIPDDQIQEAIKLGVAKVNVNTEC 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 544960038 235 RIAYSNGVKDVLNS---------DPEVIDPKKYGKKGLESVKDFVKSRMEVCGCVGKA 283
Cdd:PRK07315 236 QIAFANATRKFARDyeaneaeydKKKLFDPRKFLAPGVKAIQASVEERIDVFGSANKA 293
PRK09197 PRK09197
fructose-bisphosphate aldolase; Provisional
 8-284 2.39e-29

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 236406  Cd Length: 350  Bit Score: 114.12  E-value: 2.39e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038   8 QILLD-AQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQttpstIKYAGLDYY-------------------LAN-V 66
Cdd:PRK09197  10 QEMFDrAKENGFALPAVNVVGTDSINAVLEGAAEAKSPVIIQ-----FSNGGAAFIagkgvkddgqgaavlgaiaGAKhV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  67 KVASEKASVPVAMHLDHGSSFGL-------AMQALRVG------YTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEA 133
Cdd:PRK09197  85 HEVAEHYGVPVILHTDHCAKKLLpwidgllDAGEKHFAaggkplFSSHMIDLSEEPLEENIEICSKYLERMAKAGMTLEI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 134 ELGKV---GGKEDDLDGGDGGAYTDPLEAKEFVERTGVSS----LAVAIGTAHGLYK-GEPKLDLDRLSEIREVVS---- 201
Cdd:PRK09197 165 ELGVTggeEDGVDNSHEDNSKLYTQPEDVLYAYEALGKISgrftIAASFGNVHGVYKpGNVKLRPEILKDSQEYVSkkfg 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 202 -----VPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYSNGVKD------------VLNSDPEVI------DPKKY 258
Cdd:PRK09197 245 lpakpFDFVFHGGSGSTLEEIREAVSYGVVKMNIDTDTQWAFWRGVLDyyfknydylqgqVGNPEGEDKpnkkyyDPRVW 324

                        330       340
                 ....*....|....*....|....*.
gi 544960038 259 GKKGLESVKDFVKSRMEVCGCVGKAI 284
Cdd:PRK09197 325 LRAAEASMAARLEEAFEDLNSIGVLL 350
FBP_aldolase_IIA cd00946
Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the ...
 10-282 3.35e-27

Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is homodimeric and used in gluconeogenesis and glycolysis. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238476  Cd Length: 345  Bit Score: 108.22  E-value: 3.35e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  10 LLD-AQEGHYAVGAFNVENMEMVMAVIEAAEELKSPVILQTTPSTIK-YAGL----DYYLANVKVA----------SEKA 73
Cdd:cd00946    7 LFDyAKENGFAIPAVNCTSSSTINAVLEAARDAKSPIIIQFSNGGAAfYAGKglknEKQKASIAGAiaaahhvrsmAEHY 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038  74 SVPVAMHLDH----------------GSSFGLAMQALrvgYTSIMIDGSHESYEDNISISKSVVDACMPSDIPVEAELGK 137
Cdd:cd00946   87 GVPVVLHTDHcakkllpwfdglleadEEYFKQHGEPL---FSSHMLDLSEEPLEENIEICKKYLERMAKINMWLEMEIGI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 138 VGGK---EDDLDGGDGGAYTDPLEA----KEFVERTGVSSLAVAIGTAHGLYK-GEPKLDLDRLSEIREVVS-------- 201
Cdd:cd00946  164 TGGEedgVDNSGVDNAELYTQPEDVwyvyEALSKISPNFSIAAAFGNVHGVYKpGNVKLQPEILGEHQDYVReklgladd 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544960038 202 --VPLVLHGGSGIPDEVIKESIKRGICKVNYATELRIAYSNGVKDVL----------NSDPEVI--------DPKKYGKK 261
Cdd:cd00946  244 kpLYFVFHGGSGSTKEEIREAISYGVVKMNIDTDTQWAYWEGVRNYYlknedylqgqIGNPEGPdkpnkkyyDPRVWLRE 323

                        330       340
                 ....*....|....*....|.
gi 544960038 262 GLESVKDFVKSRMEVCGCVGK 282
Cdd:cd00946  324 GEKSMVARVKKAFEDLNSVNK 344
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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