NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|544973675|ref|WP_021376319|]
View 

MFS transporter [Clostridioides difficile]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 12-378 1.41e-26

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17335:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 375  Bit Score: 109.21  E-value: 1.41e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  12 IFYFLSYiiFAFAStkFTPFLS----KLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTMKKIVLISLSVyGITSVI 87
Cdd:cd17335    4 LFYFFFF--AALGS--LLPFLSvylkQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLA-AVLFFL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  88 MFSTESATFIIYLLLVALSGGLLNTCCSLYDTWIIG-CGDKINNYlSFIKTFGSIGWAIGSMVASYLILRFS-YSGLSVA 165
Cdd:cd17335   79 SLFFVAQIFWLLLLLVILGAFFSAPVVPLVDSITLQyLGEERERY-GKQRLWGSIGFGIAALLVGILIDRSStYKNYTIA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 166 --IGLIVVLLIINILLLPDIEKINKKINVTSKDIIELLKGKKYIL-LVCILFLLYSMVVANNCTVIdKMIALNATNSQIS 242
Cdd:cd17335  158 fyVFAVLMLLALLLALKFPFRPKHPEPNENTGGLLALLRNPRVLAfLLVAFLMGFGHGLIYSFLFW-HLQDLGGSKTLIG 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 243 LKWSLQSLLEIPTYLAGSYLLKKYSSLNLLKLSAIMITVQFLLFALTNDLNIIIILCVFQVFSTPLILITSKRLIFEVSP 322
Cdd:cd17335  237 LLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAP 316

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 544973675 323 KKLRSSSQLIALSIFMGGSSLIIPTVTGFLSINIGYNYTLM---ILSLFGCLAYGLIVL 378
Cdd:cd17335  317 PGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRffaIAALAGLLAFFLIQR 375
 
Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 12-378 1.41e-26

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 109.21  E-value: 1.41e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  12 IFYFLSYiiFAFAStkFTPFLS----KLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTMKKIVLISLSVyGITSVI 87
Cdd:cd17335    4 LFYFFFF--AALGS--LLPFLSvylkQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLA-AVLFFL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  88 MFSTESATFIIYLLLVALSGGLLNTCCSLYDTWIIG-CGDKINNYlSFIKTFGSIGWAIGSMVASYLILRFS-YSGLSVA 165
Cdd:cd17335   79 SLFFVAQIFWLLLLLVILGAFFSAPVVPLVDSITLQyLGEERERY-GKQRLWGSIGFGIAALLVGILIDRSStYKNYTIA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 166 --IGLIVVLLIINILLLPDIEKINKKINVTSKDIIELLKGKKYIL-LVCILFLLYSMVVANNCTVIdKMIALNATNSQIS 242
Cdd:cd17335  158 fyVFAVLMLLALLLALKFPFRPKHPEPNENTGGLLALLRNPRVLAfLLVAFLMGFGHGLIYSFLFW-HLQDLGGSKTLIG 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 243 LKWSLQSLLEIPTYLAGSYLLKKYSSLNLLKLSAIMITVQFLLFALTNDLNIIIILCVFQVFSTPLILITSKRLIFEVSP 322
Cdd:cd17335  237 LLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAP 316

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 544973675 323 KKLRSSSQLIALSIFMGGSSLIIPTVTGFLSINIGYNYTLM---ILSLFGCLAYGLIVL 378
Cdd:cd17335  317 PGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRffaIAALAGLLAFFLIQR 375
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 12-291 3.54e-14

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 73.05  E-value: 3.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675   12 IFYFLSYIIFAFASTKFTPFLSKLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTMKKIVLISLSVYGIT-SVIMFS 90
Cdd:pfam12832   6 GFYFFYFAALGCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLfLSVLFI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675   91 TESATFIIYLLLVALSGGLLNTCCSLYDTWIIG-CGDKINNYlSFIKTFGSIGWAIGSMVASYLILRFSYSGLSVAIGLI 169
Cdd:pfam12832  86 PISLTFWWLALLVVLFSFFWNAILPQFEVATLQhLGEKRKDY-GRQRLWGSVGFALSVFGLGALFDHYSVGLLPSVLFYL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  170 VVLLIINILLLPDI---EKINKKINVTsKDIIELLKGKKYILLVCILFLLYSMVVANNCTVIDKMIALNATNSQISLKWS 246
Cdd:pfam12832 165 FAALMLLSLLLPLAppeMEYESKGGSK-AVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGASNTLLGALWA 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 544973675  247 LQSLLEIPTYLAGSYLLKKYSSLNLLKLSAIMITVQFLLFALTND 291
Cdd:pfam12832 244 LGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFVE 288
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
11-343 1.29e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 68.08  E-value: 1.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  11 IIFYFLSYIIFAFASTKFTPFLS----KLGYSAFERGIILSSYAITNILFQLLFGVLADKYqTMKKIVLISLSVYGITSV 86
Cdd:COG2814   12 LLALALGAFLSGLGIGIVLPALPliaaDLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLLLGLLLFALGSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  87 IM-FSTESATFIIYLLLVALSGGLLNTCCSLYDTWIIGcGDKINNYLSFIKTFGSIGWAIGSMVASYLILRFSYSGL-SV 164
Cdd:COG2814   91 LCaLAPSLWLLLAARFLQGLGAGALFPAALALIADLVP-PERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVfLV 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 165 AIGLIVVLLIINILLLPDIEKINKKinVTSKDIIELLKGKKYILLVCILFLLYSMVVANNCTVIDKMIA-LNATNSQISL 243
Cdd:COG2814  170 NAVLALLALLLLLRLLPESRPAARA--RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGL 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 244 KWSLQSLLEIPTYLAGSYLLKKYSSLNLLKLSAIMITVQFLLFALTNDLNIIIILCVFQVFSTPLILITSKRLIFEVSPK 323
Cdd:COG2814  248 LLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPP 327

                        330       340
                 ....*....|....*....|
gi 544973675 324 KLRSSSQLIALSIFMGGSSL 343
Cdd:COG2814  328 EARGRASGLYNSAFFLGGPL 347
lacY PRK09528
galactoside permease; Reviewed
 10-380 1.72e-05

galactoside permease; Reviewed


Pssm-ID: 236549  Cd Length: 420  Bit Score: 46.43  E-value: 1.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  10 FIIFYFLSYIIFAFASTKFtPFLS-----KLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTMKKIVLIslsvygIT 84
Cdd:PRK09528  12 YWIFSLFFFFFFFIWSSWF-SFFPiwlhdINGLSGTDTGIIFSANSLFALLFQPLYGLISDKLGLKKHLLWI------IS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  85 SVIMFsteSATFIIYL---------LLVALSGGL-----LNTCCSLYDTWIigcgDKINNYLSF----IKTFGSIGWAIG 146
Cdd:PRK09528  85 GLLVL---FGPFFIYVfapllqyniLLGAIVGGIylgfgFLAGAGAIEAYI----ERVSRRSGFeygrARMWGSLGWALC 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 147 SMVASYLI-----LRF---SYSGLSVAIGLIVVLLIINILLLPDIEKINKKINVTSKDIIELLKGKKYILLVcilflLYS 218
Cdd:PRK09528 158 AFIAGILFninpqINFwlgSGSALILLVLLFFAKPDAPSTAKVANALGANASAVSLKDALALLKLPKFWFLV-----LYV 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 219 MVVANNCTVIDKMIAlNATNSQISLKW----------SLQSLLEIPTYLAGSYLLKKYSSLNLLKLSAIMITVQFLLFAL 288
Cdd:PRK09528 233 IGVACFYDVFDQQFP-NFFASFFATPEqgtrvfgylnSFQVFLEALIMFFAPFIINRIGAKNALLLAGTIMAVRIIGSGF 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 289 TNDLNIIIILCVFQVFSTPLILITSKRLIFEVSPKKLRSSSQLIALSIFMGGSSLIIPTVTGFLSINIGYNYTLMILSL- 367
Cdd:PRK09528 312 ATGPLEVSILKLLHAFEVPFLLVGVFKYITLNFDVRLSATIYLVGFQFAKQLGAVFLSTLAGNLYDSIGFQGTYLILGGi 391

                        410
                 ....*....|....
gi 544973675 368 -FGCLAYGLIVLLN 380
Cdd:PRK09528 392 vLLFTLISVFTLSG 405
 
Name Accession Description Interval E-value
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 12-378 1.41e-26

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 109.21  E-value: 1.41e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  12 IFYFLSYiiFAFAStkFTPFLS----KLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTMKKIVLISLSVyGITSVI 87
Cdd:cd17335    4 LFYFFFF--AALGS--LLPFLSvylkQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLA-AVLFFL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  88 MFSTESATFIIYLLLVALSGGLLNTCCSLYDTWIIG-CGDKINNYlSFIKTFGSIGWAIGSMVASYLILRFS-YSGLSVA 165
Cdd:cd17335   79 SLFFVAQIFWLLLLLVILGAFFSAPVVPLVDSITLQyLGEERERY-GKQRLWGSIGFGIAALLVGILIDRSStYKNYTIA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 166 --IGLIVVLLIINILLLPDIEKINKKINVTSKDIIELLKGKKYIL-LVCILFLLYSMVVANNCTVIdKMIALNATNSQIS 242
Cdd:cd17335  158 fyVFAVLMLLALLLALKFPFRPKHPEPNENTGGLLALLRNPRVLAfLLVAFLMGFGHGLIYSFLFW-HLQDLGGSKTLIG 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 243 LKWSLQSLLEIPTYLAGSYLLKKYSSLNLLKLSAIMITVQFLLFALTNDLNIIIILCVFQVFSTPLILITSKRLIFEVSP 322
Cdd:cd17335  237 LLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAP 316

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 544973675 323 KKLRSSSQLIALSIFMGGSSLIIPTVTGFLSINIGYNYTLM---ILSLFGCLAYGLIVL 378
Cdd:cd17335  317 PGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRffaIAALAGLLAFFLIQR 375
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 12-291 3.54e-14

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 73.05  E-value: 3.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675   12 IFYFLSYIIFAFASTKFTPFLSKLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTMKKIVLISLSVYGIT-SVIMFS 90
Cdd:pfam12832   6 GFYFFYFAALGCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLfLSVLFI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675   91 TESATFIIYLLLVALSGGLLNTCCSLYDTWIIG-CGDKINNYlSFIKTFGSIGWAIGSMVASYLILRFSYSGLSVAIGLI 169
Cdd:pfam12832  86 PISLTFWWLALLVVLFSFFWNAILPQFEVATLQhLGEKRKDY-GRQRLWGSVGFALSVFGLGALFDHYSVGLLPSVLFYL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  170 VVLLIINILLLPDI---EKINKKINVTsKDIIELLKGKKYILLVCILFLLYSMVVANNCTVIDKMIALNATNSQISLKWS 246
Cdd:pfam12832 165 FAALMLLSLLLPLAppeMEYESKGGSK-AVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGASNTLLGALWA 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 544973675  247 LQSLLEIPTYLAGSYLLKKYSSLNLLKLSAIMITVQFLLFALTND 291
Cdd:pfam12832 244 LGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFVE 288
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
11-343 1.29e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 68.08  E-value: 1.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  11 IIFYFLSYIIFAFASTKFTPFLS----KLGYSAFERGIILSSYAITNILFQLLFGVLADKYqTMKKIVLISLSVYGITSV 86
Cdd:COG2814   12 LLALALGAFLSGLGIGIVLPALPliaaDLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLLLGLLLFALGSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  87 IM-FSTESATFIIYLLLVALSGGLLNTCCSLYDTWIIGcGDKINNYLSFIKTFGSIGWAIGSMVASYLILRFSYSGL-SV 164
Cdd:COG2814   91 LCaLAPSLWLLLAARFLQGLGAGALFPAALALIADLVP-PERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVfLV 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 165 AIGLIVVLLIINILLLPDIEKINKKinVTSKDIIELLKGKKYILLVCILFLLYSMVVANNCTVIDKMIA-LNATNSQISL 243
Cdd:COG2814  170 NAVLALLALLLLLRLLPESRPAARA--RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGL 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 244 KWSLQSLLEIPTYLAGSYLLKKYSSLNLLKLSAIMITVQFLLFALTNDLNIIIILCVFQVFSTPLILITSKRLIFEVSPK 323
Cdd:COG2814  248 LLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPP 327

                        330       340
                 ....*....|....*....|
gi 544973675 324 KLRSSSQLIALSIFMGGSSL 343
Cdd:COG2814  328 EARGRASGLYNSAFFLGGPL 347
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-372 5.39e-12

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 66.42  E-value: 5.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675   1 MINKAIKFKFII---FYFLSYIIFAFASTKFTPFLSKLGYSAFERGIILSSYAITNILFQLLFGVLADKYqTMKKIVLIS 77
Cdd:COG0738    1 MSKKNYRRALIAiylLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRF-GYKRGLLLG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  78 LSVYGITSVIMFSTES-ATFIIYLLLVALSGGLLNTCCSLYdtwIIGCGDKINN-YLSFIKTFGSIGWAIGSMVASYLIL 155
Cdd:COG0738   80 LLLMALGLLLFALAPSyPLLLLALFLLGLGLGLLDVAANPY---VAALGPETAAsRLNLLHAFFSLGALLGPLLGGLLIL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 156 -------RFSYSGLSVAIglIVVLLIINILLLPDIEKINKKINVTSKDIIELLKGKKYILLVCILFLLYSM-VVANNCTV 227
Cdd:COG0738  157 lglslswHLPYLILAVLL--LLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAeGAIGDWLP 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 228 IDKMIALNATNSQISLKWSLQSLLEIPTYLAGSYLLKKYSSLNLLKLSAIMITVQFLLFALTNDLNIIIILCVFQVFSTP 307
Cdd:COG0738  235 LYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLS 314

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544973675 308 LILITSKRLIFEVSPKklRSSSQLIALSIFMGGSSLIIPTVTGFLSINIGYNYTLMILSLFGCLA 372
Cdd:COG0738  315 LMFPTIFSLALDGLGK--RTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLI 377
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 15-379 1.21e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 65.29  E-value: 1.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  15 FLSYIIFAFASTKFTPFLSKLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTmKKIVLISLSVYGITSVIM-FSTES 93
Cdd:cd17325    6 FLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGR-KRLLLLGLLLLAVSTLLFaFATSY 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  94 ATFIIYLLLVALSGGLLNTCCSLY--DTWIIgcgDKINNYLSFIKTFGSIGWAIGSMVASYLILRFSYS----GLSVAIG 167
Cdd:cd17325   85 WQLLLARFLQGLASAAVWPAAMALiaDIAPP---EERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRapflVCAALAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 168 LIVVLLIINILLLPDIEKINKKINVTSKDIIELLKGKKYILLVCILFLLYSMVVANNCTVIDKMIA--LNATNSQISLKW 245
Cdd:cd17325  162 LALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAelGGLSPAQIGLLF 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 246 SLQSLLEIPTYLAGSYLLKKYSSLNLLKLSAIMITVQFLLFALTNDLNIIIILCVFQVFSTPLILITSKRLIFEVSPKKL 325
Cdd:cd17325  242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG 321

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 544973675 326 RSSSqLIALSIFMGGSSLIIPTVTGFLSINIGYNYTLMILSLFgCLAYGLIVLL 379
Cdd:cd17325  322 RGTA-MGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAAL-LLLAAVLFLL 373
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 14-301 4.91e-09

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 57.56  E-value: 4.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  14 YFLSYIIFAFASTKFTPFLS-----KLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTMKKIVLISLsVYGITSVIM 88
Cdd:cd17471    1 LLLATLLTGLAGAFVLPYLSlflteELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLAL-LAGALGYLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  89 FSTeSATFIIYLLLVALSGGLLNTCCSL-----YDTWIIGCGDKINNYLSFIKTFGSIGWAIGSMVASYLILRFSYSGLS 163
Cdd:cd17471   80 FAF-LRNYWVLLLVGVVLLSLGAAAFPQlfalaREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 164 VAIGLIVVLLIINILLLPDIEKINKKINVTSKDIIELLKGKKYILLVCILFLLYsmvVANNCTVIDKMIA----LNATNS 239
Cdd:cd17471  159 LLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLF---AANSMYIIAMPLYvtneLGGSES 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544973675 240 QISLKWSLQSLLEIPTYLAGSYLLKKYSSLNLLKLSAIMITVQFLLFALTNDLNIIIILCVF 301
Cdd:cd17471  236 WVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLL 297
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 10-379 5.18e-09

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 57.44  E-value: 5.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  10 FIIFYFLSYIIFAFASTKFTPFLSKLGYSAFERGIILSSYAITNILFQLLFGVLADKYqTMKKIVLISLSVYGITSVIM- 88
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-GRRPVLLLGLLLFALGALLFa 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  89 FSTESATFIIYLLLVALSGGLLNTCCSLYDTWIIGcGDKINNYLSFIKTFGSIGWAIGSMVASYLILRFSYS-----GLS 163
Cdd:cd06174   80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFP-ERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwravfLIA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 164 VAIGLIVVLLIINILLLPDIEKINKKINVTSKDIIELLKGKKYILLVCILFLLYSMVVANNCTVID-----KMIALNATN 238
Cdd:cd06174  159 AALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTllplfLLDLGGLSV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 239 SQISLKWSLQSLLEIPTYLAGSYLLKKYSSL-NLLKLSAIMITVQFLLFALTNDLNIIIILCVFQVFSTPLILITSKRLI 317
Cdd:cd06174  239 AVAGLLLSLFGLAGALGSLLLGLLSDRLIGRkPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544973675 318 FEVSPKKLRSSSQLIaLSIFMGGSSLIIPTVTGFLsINIGYNYTLMILSLFGCLAYGLIVLL 379
Cdd:cd06174  319 AELFPPEIRGTAFGL-LNTFGFLGGAIGPLLAGFL-LAATFGLTGAFLVLAVLLLLAAILLL 378
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
11-379 5.32e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 54.11  E-value: 5.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  11 IIFYFLSYIIFAFASTKFTPFLSKLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTmKKIVLISLSVYGITSVIM-F 89
Cdd:COG2271   16 FLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGR-RRVLAIGLLLWGLATLLFgF 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  90 STESATFIIYLLLVALSGGLLNTCCSLYDT-WIIgcGDKINNYLSFIKTFGSIGWAIGSMVASYLILRFSYSGLSVAIGL 168
Cdd:COG2271   95 ATSFWQLLLLRFLLGLGEAGFFPAALKLIAeWFP--PKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 169 IVVLLIINIlllpdiekinkkinvtskdiiellkgkkyILLVCILFLLYSMVVANNCTVIDKMI--ALNATNSQISLKWS 246
Cdd:COG2271  173 PGLLLALLR-----------------------------FWLLALAYFLVYFALYGFLTWLPTYLveVRGLSLAQAGLLLS 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 247 LQSLLEIPTYLAGSYLLKKYSSLN--LLKLSAIMITVQFLLFALTNDLNIIIILCVFQVFSTPLILITSKRLIFEVSPKK 324
Cdd:COG2271  224 LPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKK 303

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 544973675 325 LRSSSQLIALSIFMGGSSLiIPTVTGFLSINIGYNYTLMILSLFGCLAYGLIVLL 379
Cdd:COG2271  304 ARGTASGLVNTFGFLGGAL-GPLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 11-379 1.09e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 53.39  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  11 IIFYFLSYIIFAFASTKFTPFLSK-----LGYSAFERGIILSSYAITNILFQLLFGVLADKYQTmKKIVLISLSVYGITS 85
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIylhqqLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGR-KPVMLAGLLLRALGF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  86 VIMFSTESA-TFIIYLLLVALSGGLLNTCCSLYDTWIIGCGDKINNYlSFIKTFGSIGWAIGSMVASYLiLRFSYSGLSV 164
Cdd:cd17329   80 ALLGFAHSPwLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAF-SLLYWAINLGVAIGPLLGGLL-LLYSFRLLFL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 165 AIGLIVVLLIINILLLPDIEKINKKINVTSKDIIEL---LKGKKYILLVCILFLLYSMVVA-NNCTVIDKMIALNATNSQ 240
Cdd:cd17329  158 AAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYkivLRDRAFLLFLLASFLISLIYFQlESTLPVYVVEILGLGESL 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 241 ISLKWSLQSLLEIPTYLAGSYLLKKYSSLNLLKLSAIMITVQFLLFALTNDLNIIIILCVFQVFSTPLILITSKRLIFEV 320
Cdd:cd17329  238 LGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAAL 317

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 544973675 321 SPKKLRSSSQLIAlSIFMGGSSLIIPTVTGFLSINIGYNYTLMILSLFGCLAYGLIVLL 379
Cdd:cd17329  318 APPDKRGSYMGFY-ALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
MFS_1 pfam07690
Major Facilitator Superfamily;
10-343 1.17e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 53.19  E-value: 1.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675   10 FIIFYFLSYIIFAFASTKFTPFLSK-LGYSAFERGIILSSYAITNILFQLLFGVLADKYQTmKKIVLISLSVYGITSV-I 87
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEdLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGR-RRVLLIGLLLFALGLLlL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675   88 MFSTESATFIIYLLLVALSGGLLNTCCSLYDTWIIGcGDKINNYLSFIKTFGSIGWAIGSMVASYLILRFSYSGLSVAIG 167
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFP-PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  168 LIVVLLIINILLLPD-----IEKINKKINVTSKDIIELLKGKKYILLVCILFLLYSMVVANNCTVIDKMIALNATNSQIS 242
Cdd:pfam07690 159 ILSLLAAVLLLLPRPppeskRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  243 LKWSLQSLLEIPTYLAGSYLLKKYSSLNLLK---LSAIMITVQFLLFALTNDLNIIIILCVFQVFSTPLILITSKRLIFE 319
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLlalLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318

                         330       340
                  ....*....|....*....|....
gi 544973675  320 VSPKKLRSSSQLIALSIFMGGSSL 343
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLGGAL 342
MFS_LacY cd06172
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ...
 10-372 3.05e-07

LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340862 [Multi-domain]  Cd Length: 389  Bit Score: 51.85  E-value: 3.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  10 FIIFYFLSY-IIFAFASTKFTpflSKLGYSAFERGIILSSYAITNILFQLLFGVLADKYqTMKKIVLISLS--------- 79
Cdd:cd06172    7 FFFLFFFIWsASFSFFPIWLT---QINHLSGSETGIVFSANSLFALLFQPVYGLISDKL-GLKKHLLWFISgllvlfgpf 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  80 ---VYGITSVIMFSTESATFIIYLLLVALSGgllntcCSLYDTWIIGCGDKINNYLSFIKTFGSIGWAIGSMVASYLI-- 154
Cdd:cd06172   83 fifVYGPLLQSNILLGAIVGGIYLGFAFLAG------CGAIESYIERVSRRFNFEYGRARMWGSLGWALAAFFAGILFni 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 155 ---LRFSYSGLSVAIGLIVVLLIINILLLPDIEKINKKINVTSKDIIELLKGKKYILlvcilFLLYSMVVANNCTVIDKM 231
Cdd:cd06172  157 npnINFWLGSGFALILLLLLLFAKPEDSDTAAAAGANASSVSLKDVLELFRMPKFWF-----FILFVIGVSCFYDVFDQQ 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 232 IALNAT---------NSQISLKWSLQSLLEIPTYLAGSYLLKKYSSLNLLKLSAIMITVQFLLFALTNDLNIIIILCVFQ 302
Cdd:cd06172  232 FPPYFTslfatpeqgNRVFGYLNSAQVFLEAGMMFLAPLIVNRIGAKNGLLLAGTIMAVRIIGSGLATSPLEISILKLLH 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 303 VFSTPLILITSKRLIFEVSPKKLRSSSQLIALSIFMGGSSLIIPTVTGFLSINIGYNYTLMILSLFGCLA 372
Cdd:cd06172  312 AFEVPLLLVSIFKYITSHFDTRLSATLYLVGFQFAKQLGAVVLSPLAGNLYDSIGFQQTYLVLGGIVLVF 381
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 28-372 1.55e-06

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 49.53  E-value: 1.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  28 FTPFLSKLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTMKKIVLISLSVYGITSVIMFSTESATFIiyLLLVALSG 107
Cdd:cd17490   19 LSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIMILFPSPWGL--LIARFLSG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 108 gllntccSLYDTWIIGC--------GDKINNYLSFIKTFGSIGWAIGSMVASYLILRFSYSGLSVAIGLIVVLLIINILL 179
Cdd:cd17490   97 -------IAAATWVSFTvlyasyfpPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLF 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 180 LPDIEKINKKINVTSKDIIELLKgKKYILLVCILFLLYSMVVANNCTVIDKMIA--LNATNSQISLKWSLQSLLEI-PTY 256
Cdd:cd17490  170 IKEERREKKPVLTELKELLSVLK-DKKLLFFSLLAILQQMITFSTTFGFTPLIAkqLGASSFQLGLLSIIYLLPNAlASL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 257 LAGSYLLKKYSSLNLLKLSAIMITVQFLLFALTNDLNIIIILCVFQVFSTPLILITSKRLIFEVSPKKLRSSSQLIALSI 336
Cdd:cd17490  249 LSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAI 328

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 544973675 337 FMGGSSLiIPTVTGFLSINIGYNYTLMILSLFGCLA 372
Cdd:cd17490  329 YALGMFL-GPVLVGIISEAFGLQTGFFVIGVIALLA 363
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 6-167 2.45e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 49.11  E-value: 2.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675   6 IKFKFIIFYFLSYIIFAFASTKFTPFLS-----KLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTmKKIVLISLSV 80
Cdd:cd17325  196 LRDRRLLALFLAIFVLAFAFGALEPFLPlyaaeLGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGR-KPLILIGLLL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  81 YGITSVIMFSteSATFIIYLLLVALSGGLLNTCCSLYDTWIIGCGDKIN--NYLSFIKTFGSIGWAIGSMVASYLILRFS 158
Cdd:cd17325  275 SAVALLLLPL--ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGrgTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352


                 ....*....
gi 544973675 159 YSGLSVAIG 167
Cdd:cd17325  353 FATPFLAAA 361
lacY PRK09528
galactoside permease; Reviewed
 10-380 1.72e-05

galactoside permease; Reviewed


Pssm-ID: 236549  Cd Length: 420  Bit Score: 46.43  E-value: 1.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  10 FIIFYFLSYIIFAFASTKFtPFLS-----KLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTMKKIVLIslsvygIT 84
Cdd:PRK09528  12 YWIFSLFFFFFFFIWSSWF-SFFPiwlhdINGLSGTDTGIIFSANSLFALLFQPLYGLISDKLGLKKHLLWI------IS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  85 SVIMFsteSATFIIYL---------LLVALSGGL-----LNTCCSLYDTWIigcgDKINNYLSF----IKTFGSIGWAIG 146
Cdd:PRK09528  85 GLLVL---FGPFFIYVfapllqyniLLGAIVGGIylgfgFLAGAGAIEAYI----ERVSRRSGFeygrARMWGSLGWALC 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 147 SMVASYLI-----LRF---SYSGLSVAIGLIVVLLIINILLLPDIEKINKKINVTSKDIIELLKGKKYILLVcilflLYS 218
Cdd:PRK09528 158 AFIAGILFninpqINFwlgSGSALILLVLLFFAKPDAPSTAKVANALGANASAVSLKDALALLKLPKFWFLV-----LYV 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 219 MVVANNCTVIDKMIAlNATNSQISLKW----------SLQSLLEIPTYLAGSYLLKKYSSLNLLKLSAIMITVQFLLFAL 288
Cdd:PRK09528 233 IGVACFYDVFDQQFP-NFFASFFATPEqgtrvfgylnSFQVFLEALIMFFAPFIINRIGAKNALLLAGTIMAVRIIGSGF 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 289 TNDLNIIIILCVFQVFSTPLILITSKRLIFEVSPKKLRSSSQLIALSIFMGGSSLIIPTVTGFLSINIGYNYTLMILSL- 367
Cdd:PRK09528 312 ATGPLEVSILKLLHAFEVPFLLVGVFKYITLNFDVRLSATIYLVGFQFAKQLGAVFLSTLAGNLYDSIGFQGTYLILGGi 391

                        410
                 ....*....|....
gi 544973675 368 -FGCLAYGLIVLLN 380
Cdd:PRK09528 392 vLLFTLISVFTLSG 405
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 31-372 3.46e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 45.24  E-value: 3.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  31 FLSKLGYSAFERGIILSSYAITNILFQLLFGVLADKYqTMKKIVLISLSVYGIT-SVIMFSTESATFIIYLLLVALSGGL 109
Cdd:cd17478   22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRK-PRRYLLPLGPLLTGLGlSLLGFAPNYWLLLLLVALAGIGSAA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 110 LNTCCSLYDTwiIGCGDKINNYLSFIKTFGSIGWAIGSMVASYLILRFSYSGLSV--AIGLIVVLLIINILLLPDIEKIN 187
Cdd:cd17478  101 FHPEGARLAS--QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLIllIIPGLAVALLLLRLRPLKKPEAK 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 188 KKINVTSKDIIELLKGKKYILLVCILFLLYSMVVANNCTVIDKMIALNATNSQISLKWSLQSLLEIPTYLAGSYLLKKYS 267
Cdd:cd17478  179 KAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFG 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 268 SLNLLKLSAIMITVQFLLFALTNDLNIII---ILCVFQVFSTPLILITSKRLIfevsPKKLRSSSQLI-ALSIFMGGssl 343
Cdd:cd17478  259 RRRVIIASLLLAAPFLLLFLLTPGIWSYIllvLAGFLLFASFPVTVVLAQELL----PGNVGLASGLMmGLSFGLGG--- 331

                        330       340
                 ....*....|....*....|....*....
gi 544973675 344 IIPTVTGFLSINIGYNYTLMILSLFGCLA 372
Cdd:cd17478  332 IGAPVLGALADAFGLESVLLILALLPLLG 360
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 35-379 1.24e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 43.72  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  35 LGYSAFERGIILSSYAITNILFQLLFGVLADKYqTMKKIVLISLSVYGITSVIMFSTESATFIIYL-LLVALSGGLLNTC 113
Cdd:cd17473   30 VPNSELLVPLLLTLPALFIALFAPLAGWLADRF-GRKRLLIAGLLLYGIGGVAGLFLDSLYALLASrALLGIGVAGIMTL 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 114 CslydTWIIG---CGDKINNYLSFIKTFGSIGWAIGSMVASYLI-LRFSYSGLSVAIGLIVVLLIINILLLPDIEKINKK 189
Cdd:cd17473  109 A----TALIGdyfEGEERAKMLGLQSAAMSLGGVVFLLLGGALAeIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAA 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 190 INVTSK-DIIELLKGKKYILLVCILFLLYSMVVANNCTVIDKMIALNAtnSQISLKWSLQSLLEIPTYLAGSYLLKKYSS 268
Cdd:cd17473  185 SPGAATaAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSA--ALIGLALAIASLAGAIGALLFGRLKRRLGK 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 269 LNLLKLSAIMITVQFLLFALTNDLNIIIILCVFQVFSTPLILITSKRLIFEVSPKKLRSssqlIALSIFMGGSSL---II 345
Cdd:cd17473  263 RRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRG----RAMGIVTSAFFLgqfLS 338

                        330       340       350
                 ....*....|....*....|....*....|....
gi 544973675 346 PTVTGFLsINIGYNYTLMILSLFGCLAYGLIVLL 379
Cdd:cd17473  339 PLVLGPL-VNLTGGLSGAFLILGVLALVLAIVLL 371
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
11-379 3.33e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.56  E-value: 3.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  11 IIFYFLSYIIFAFASTKFTPFLSKLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTmKKIVLISLSVYGITSVIM-F 89
Cdd:COG2223   11 TLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGP-RRVLLIGLLLLGIGLLLLaL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  90 STESATFIIYLLLVALSGGLL-NTCCSLYDTWIIgcGDKINNYLSFIKTFGSIGWAIGSMVASYLI----LRFSYSGLSV 164
Cdd:COG2223   90 AVSYWLLLLLGLLLGIGGGGSfAVGIALVSKWFP--PDRRGLALGLAAGGGNLGAAVAAFLAPLLIaafgWRNAFLILGI 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 165 AIGLIVVLLIINILLLPDIEKINKKINVtsKDIIELLKGKKYILLVCILFLLYSMVVANNcTVIDKMIALNATNSQISLK 244
Cdd:COG2223  168 LLLVVAVLAWLFLRDPPAGAAAAAKASL--RDQLEALRDPRFWLLSLLYFGTFGSFIGFS-SWLPPYLVDQFGLSAATAG 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 245 W--SLQSLLEIPTYLAGSYLLKKYSSLNLLKLS-AIMITVQFLLFALTNDLNIIIILCVFQVFSTPLILITSKRLIFEVS 321
Cdd:COG2223  245 LlaALFALLGALGRPLGGWLSDRIGGRRVLLIVfALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIF 324

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 322 PKKLRSS-SQLIALSIFMGGssLIIPTVTGFLSINIG-YNYTLMILSLFGCLAYGLIVLL 379
Cdd:COG2223  325 PTKNAGAvYGLVGAAGGLGG--FLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLL 382
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 33-379 3.35e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 42.17  E-value: 3.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  33 SKLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTmKKIVLISLSVYGITSVIMFSTES-ATFIIYLLLVALSGGLLN 111
Cdd:cd17474   27 EALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGR-KKVLLPGLLLFGIGGLLCGLSDSfALLLAGRALQGIGAAGLG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 112 tccSLYDTWIIGC--GDKINNYLSFIKTFGSIGWAIGSMVASYLIL---RFSYSGLSVAIGliVVLLIINILLLPDIEKI 186
Cdd:cd17474  106 ---PLALTLIGDLfeGGERAKAMGLYEAALGLGIAVGPLLGGLLAAiswRYPFFLLAALIP--VAFLAILFLLPEPKEKA 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 187 NKKINVTSKDIIELLKGK---KYILLVCILFLLYSMVVANNCTVIDKMIALNATNSQ-ISLKWSLqsLLEIPTYLAGSYL 262
Cdd:cd17474  181 KSSSATKLRDLKKALRGRgllTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGlLFAGWSV--LLALGSLFVGRLL 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 263 LKKYSSLNLLKLSAIMITVQFLLFALTNDLNIIIILCVFQVFSTPLILITSKRLIFEVSPKKLRSS-SQLIALSIFMGGS 341
Cdd:cd17474  259 KKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTaSSLYNFVRFLGQA 338

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 544973675 342 slIIPTVTGFLSINIGYNYTLMILSLFGCLAYGLIVLL 379
Cdd:cd17474  339 --VGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
3-313 5.28e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.81  E-value: 5.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675   3 NKAIKFKFIIFYFLSYIIFAFASTKFTPFLSK-----LGYSAFERGIILSSYAITNILFQLLFGVLADKYQT----MKKI 73
Cdd:COG2211    4 KKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYfytdvLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTrwgrRRPW 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  74 VLISLSVYGITSVIMFSTESATFIIYLLLVALSGGLLNTCCSL----YDTWIigcGDKINNY------LSFIKTFGSIGW 143
Cdd:COG2211   84 ILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLvnipYSALG---AELTPDYeertrlSSWRFAFAGLGG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 144 AIGSMVASYLILRFS------YSGLSVAIGLIVVLLIINILLLPDIEKINKKINVTSKDIIELLKGKKYILLVCILFLLY 217
Cdd:COG2211  161 LLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 218 SMVVANNCTVIDKMIA--LNATNSQISLKWSLQSLLEIPTYLAGSYLLKKYSSLNLLKLSAIMITVQFLLFALTNDLNII 295
Cdd:COG2211  241 FLALALVAALLLYYFKyvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLW 320

                        330
                 ....*....|....*...
gi 544973675 296 IILCVFQVFSTPLILITS 313
Cdd:COG2211  321 LLLVLAALAGIGLGAILV 338
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
10-161 8.21e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.01  E-value: 8.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  10 FIIFYFLSYIIFAFASTKFTPFLSK-LGYSAFERGIILSSYAITNILFQLLFGVLADKYQTMKKIVLISLSVYGITSVIM 88
Cdd:COG2271  185 LALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLL 264

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544973675  89 FSTESATFIIYLLLvALSGGLLNTCCSLYDTWIIGCGDKINNY--LSFIKTFGSIGWAIGSMVASYLILRFSYSG 161
Cdd:COG2271  265 LALLPSPALAIALL-FLAGFGLGGAFGLLWALAAELFPKKARGtaSGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 8-108 1.21e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 40.52  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675   8 FKFIIFYFLS----YIIFAFAstkfTPFLSK-LGYSAFERGIILSSYAITNILFQLLFGVLADKYQTmKKIVLISLSVYG 82
Cdd:COG2270  241 LRFLLAYFFYrdgvQTVIAFA----GIYAAGvLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGP-KRVILVSLVIWI 315

                         90       100
                 ....*....|....*....|....*..
gi 544973675  83 ITSVIMFSTESAT-FIIYLLLVALSGG 108
Cdd:COG2270  316 VVCLAAYFLTTALaFWILGLLIGLVMG 342
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 15-222 1.24e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 40.66  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  15 FLSYIIFAFASTKFTPFLSKLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTmKKIVLISLSVYGITSVIM-FSTES 93
Cdd:cd17489    6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGR-KRLLLIGLLIFALATLLYlLATSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  94 ATFIIYLLLVALSGGLLNTCCSLYDTWIIGcGDKINNYLSFIKTFGSIGWAIGSMVASYLILRFSYSGLSVAIGLIVVLL 173
Cdd:cd17489   85 ALLLVLRLIHGIGWGAFTTAAATLVADIIP-PSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLA 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 544973675 174 IINILLLPDIEKINKKINVTSKDIIELLKGKKyILLVCILFLLYSMVVA 222
Cdd:cd17489  164 LLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKK-VLPPALILFLASIAYG 211
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 8-154 1.65e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.10  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675   8 FKFIIFYFLSYIIFAFASTKFTPFLSK-LGYSAFERGIILSSYAITNILFQLLFGVLADKYQTMKKIVLISLSVYGITSV 86
Cdd:cd06174  206 WLLLLAIFLVNLAYYSFSTLLPLFLLDlGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLA 285

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 544973675  87 IMFSTES-ATFIIYLLLVALSGGLLNTCCSLYDTwIIGCGDKINNYLSFIKTFGSIGWAIGSMVASYLI 154
Cdd:cd06174  286 LLLLAPSlLLLLLLLLLLGFGLGGLLPLSFALIA-ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 16-158 1.98e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 39.79  E-value: 1.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  16 LSYIIFAFASTKFTPFL----SKLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTmKKIVLISLSVYGITSVIM-FS 90
Cdd:COG0477   21 LGTFLEGLDFTIVNVALpsiaADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGR-KRVLLIGLLLFGLASLLCgLA 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544973675  91 TESATFIIYLLLVALSGGLLNTCCSLYDTWIIGcGDKINNYLSFIKTFGSIGWAIGSMVASYLILRFS 158
Cdd:COG0477  100 PSPELLIAARALQGIGAGGLMPGALALIAELFP-ARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
15-114 2.02e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.86  E-value: 2.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  15 FLSYIIFAFastkFTPFLSKLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTMKKIVLISLSVYGITSVIMFSTESA 94
Cdd:COG2807  229 LLYYAVVAW----LPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGS 304

                         90       100
                 ....*....|....*....|
gi 544973675  95 TFIIYLLLVALSGGLLNTCC 114
Cdd:COG2807  305 LPWLWAVLLGLGQGGLFPLA 324
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 3-167 2.23e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 39.86  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675   3 NKAIKFKFIIFYFLSYIIFaFASTKFTPFLSKLGY--SAFERGIILSSYAITNILFQLLFGVLADKYQTMKKIVLISLSV 80
Cdd:cd17474  196 RGRGLLTFLVSAFLYFFLY-FAFLTYLPFLLELLYgiSPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  81 YGITSVIMFSTESATFIIylLLVALSGGLLNTCCSLYDTWIIGCGDKINN--YLSFIKTFGSIGWAIGSMVASYLILRFS 158
Cdd:cd17474  275 YALSLLLLGFVPSLALLL--IAIVLFGLGLGLNLPLLTTLVTELAPEEERgtASSLYNFVRFLGQAVGPLLFGLLLEIFG 352


                 ....*....
gi 544973675 159 YSGLSVAIG 167
Cdd:cd17474  353 LSAPFLVGA 361
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 31-167 3.52e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.08  E-value: 3.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  31 FLSKLGYSAFERGIILSSYAITNILFQLLFGVLADKYQtmKKIVLISLSVYGITSVIMFSTESATFIIYLLLVALSGGLL 110
Cdd:cd17477  214 YGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFD--RRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAA 291

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544973675 111 NTccsLYDTWIIGCGDKI--------NNYLSFIKTFGSIgwaIGSMVASYLILRFSYSGLSVAIG 167
Cdd:cd17477  292 GP---LYTLALALAGDRLpgdelvaaNAALLLLYGLGSV---IGPLLAGALMDAFGPHGLFLFLA 350
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 38-375 6.73e-03

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 38.36  E-value: 6.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  38 SAFERGIILSSYAITNILFQLLFGVLADKYqTMKKIVLISLSVYGITSVIMF----STESATFIIYLLLVALSGGLLNTC 113
Cdd:cd17394   32 SNFQASLVQFAFFGAYFIMAIPAGMLIKRY-GYKKGILLGLGLYAIGALLFIpaasLRTYGLFLIALFVLASGLALLQTA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 114 CSLYDTwIIGCGDKINNYLSFIKTFGSIGWAIGSMVASYLILRFSYSG---------------------------LSVAI 166
Cdd:cd17394  111 ANPYVT-VLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTatalaamsaaelqayktaelasvqlpyLGIAL 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 167 GLIVVLLIINILLLPDIEKINKKINVTSKDIIELLKGKKYILLVCILFLLYSMVVANNCTVI----DKMIALNATNSQ-- 240
Cdd:cd17394  190 VLLLLAVLILLSKLPEIEAAEAEALGSKGTLLRLLKNPHLRLGVLAIFFYVGAEVAIWSFLInylmEYIAGLTETSAAtf 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675 241 ISLKWSLQSLleipTYLAGSYLLKKYSSLNLLKLSAIMITVqFLLFALTNDLNIIIILCVFQVFSTPLILITSKRLIFEV 320
Cdd:cd17394  270 VSYYWGGFMV----GRFLGTALLKKISPKKLLAVFALLGLL-LLLGAIFTGGMVALYALVLVGFFNSIMFPTIFSLALKG 344

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 544973675 321 SPKKLRSSSQLIALSIFMGGsslIIPTVTGFLSINIG---YNYTLMILSLFGCLAYGL 375
Cdd:cd17394  345 LGKHTKTGSGLLVMAIVGGA---VVPLIQGAVADDAAglrIAFLVPLLCFAYILFYGL 399
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
10-111 8.19e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 37.94  E-value: 8.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544973675  10 FIIFYFLSYIIFAFASTKFTPFL-SKLGYSAFERGIILSSYAITNILFQLLFGVLADKYQTmKKIVLISLSVYGITSVIM 88
Cdd:COG2223  210 LSLLYFGTFGSFIGFSSWLPPYLvDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG-RRVLLIVFALMALGLLLL 288

                         90       100
                 ....*....|....*....|....*
gi 544973675  89 FSTES--ATFIIYLLLVALSGGLLN 111
Cdd:COG2223  289 ALALGslWLFLVLFLLLGLALGGGN 313
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH