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Conserved domains on  [gi|545169223|ref|WP_021523678|]
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alpha/beta hydrolase [Escherichia coli]

Protein Classification

alpha/beta hydrolase( domain architecture ID 11429202)

alpha/beta hydrolase catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
53-266 3.18e-28

Acetyl esterase/lipase [Lipid transport and metabolism];


:

Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 106.88  E-value: 3.18e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223  53 VLIIPGGGYRRIVYEReGLDVGRWIA-GQGYTAFILSYRMPSVNGYY-SFADAKNALNFI----SYWAGMSERtfksVGC 126
Cdd:COG0657   16 VVYFHGGGWVSGSKDT-HDPLARRLAaRAGAAVVSVDYRLAPEHPFPaALEDAYAALRWLranaAELGIDPDR----IAV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223 127 MGFSAGGHLAGYIThLHYEEETSVRPDWMALIYPVISLDRSIAHqgcrkrlldageseysASLENsvteyTPPVFIVHAT 206
Cdd:COG0657   91 AGDSAGGHLAAALA-LRARDRGGPRPAAQVLIYPVLDLTASPLR----------------ADLAG-----LPPTLIVTGE 148
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223 207 DDkdVPVIHSLRYFNSIRDKGHHAEAHFFDKGGHGFGVsGKNGYPIEKWQSLLLEWLAEH 266
Cdd:COG0657  149 AD--PLVDESEALAAALRAAGVPVELHVYPGGGHGFGL-LAGLPEARAALAEIAAFLRRA 205
 
Name Accession Description Interval E-value
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
53-266 3.18e-28

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 106.88  E-value: 3.18e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223  53 VLIIPGGGYRRIVYEReGLDVGRWIA-GQGYTAFILSYRMPSVNGYY-SFADAKNALNFI----SYWAGMSERtfksVGC 126
Cdd:COG0657   16 VVYFHGGGWVSGSKDT-HDPLARRLAaRAGAAVVSVDYRLAPEHPFPaALEDAYAALRWLranaAELGIDPDR----IAV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223 127 MGFSAGGHLAGYIThLHYEEETSVRPDWMALIYPVISLDRSIAHqgcrkrlldageseysASLENsvteyTPPVFIVHAT 206
Cdd:COG0657   91 AGDSAGGHLAAALA-LRARDRGGPRPAAQVLIYPVLDLTASPLR----------------ADLAG-----LPPTLIVTGE 148
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223 207 DDkdVPVIHSLRYFNSIRDKGHHAEAHFFDKGGHGFGVsGKNGYPIEKWQSLLLEWLAEH 266
Cdd:COG0657  149 AD--PLVDESEALAAALRAAGVPVELHVYPGGGHGFGL-LAGLPEARAALAEIAAFLRRA 205
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
95-266 2.62e-08

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 53.00  E-value: 2.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223   95 NGYYSFADaknalnFISYWAGMSERTFKS---VGCMGFSAGGHLAGYITHLH---YEEETSVRP--DWMALIY-PVISLD 165
Cdd:pfam00326  40 LGQNEFDD------FIAAAEYLIEQGYTDpdrLAIWGGSYGGYLTGAALNQRpdlFKAAVAHVPvvDWLAYMSdTSLPFT 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223  166 RSIAHQGCRKRLLDAGESEYSASLENSVTEYtPPVFIVHATDDKDVPVIHSLRYFNSIRDKGHHAEAHFFDKGGHGFGvS 245
Cdd:pfam00326 114 ERYMEWGNPWDNEEGYDYLSPYSPADNVKVY-PPLLLIHGLLDDRVPPWQSLKLVAALQRKGVPFLLLIFPDEGHGIG-K 191
                         170       180
                  ....*....|....*....|.
gi 545169223  246 GKNGYpieKWQSLLLEWLAEH 266
Cdd:pfam00326 192 PRNKV---EEYARELAFLLEY 209
 
Name Accession Description Interval E-value
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
53-266 3.18e-28

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 106.88  E-value: 3.18e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223  53 VLIIPGGGYRRIVYEReGLDVGRWIA-GQGYTAFILSYRMPSVNGYY-SFADAKNALNFI----SYWAGMSERtfksVGC 126
Cdd:COG0657   16 VVYFHGGGWVSGSKDT-HDPLARRLAaRAGAAVVSVDYRLAPEHPFPaALEDAYAALRWLranaAELGIDPDR----IAV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223 127 MGFSAGGHLAGYIThLHYEEETSVRPDWMALIYPVISLDRSIAHqgcrkrlldageseysASLENsvteyTPPVFIVHAT 206
Cdd:COG0657   91 AGDSAGGHLAAALA-LRARDRGGPRPAAQVLIYPVLDLTASPLR----------------ADLAG-----LPPTLIVTGE 148
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223 207 DDkdVPVIHSLRYFNSIRDKGHHAEAHFFDKGGHGFGVsGKNGYPIEKWQSLLLEWLAEH 266
Cdd:COG0657  149 AD--PLVDESEALAAALRAAGVPVELHVYPGGGHGFGL-LAGLPEARAALAEIAAFLRRA 205
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
53-266 2.54e-15

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 73.13  E-value: 2.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223  53 VLIIPGGGYRRivyEREGLDVGRWIAGQGYTAFILSYR----MPSVNGYYSFADAKNALNFIsywAGMSERTFKSVGCMG 128
Cdd:COG1506   26 VVYVHGGPGSR---DDSFLPLAQALASRGYAVLAPDYRgygeSAGDWGGDEVDDVLAAIDYL---AARPYVDPDRIGIYG 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223 129 FSAGGHLAGYITHLHyeeetSVRPDWMALIYPVISLDRSIAHQGCRKRLLDAGESEYSASL-ENSVTEY----TPPVFIV 203
Cdd:COG1506  100 HSYGGYMALLAAARH-----PDRFKAAVALAGVSDLRSYYGTTREYTERLMGGPWEDPEAYaARSPLAYadklKTPLLLI 174
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 545169223 204 HATDDKDVPVIHSLRYFNSIRDKGHHAEAHFFDKGGHGFGvsgknGYPIEKWQSLLLEWLAEH 266
Cdd:COG1506  175 HGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFS-----GAGAPDYLERILDFLDRH 232
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
95-266 2.62e-08

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 53.00  E-value: 2.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223   95 NGYYSFADaknalnFISYWAGMSERTFKS---VGCMGFSAGGHLAGYITHLH---YEEETSVRP--DWMALIY-PVISLD 165
Cdd:pfam00326  40 LGQNEFDD------FIAAAEYLIEQGYTDpdrLAIWGGSYGGYLTGAALNQRpdlFKAAVAHVPvvDWLAYMSdTSLPFT 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223  166 RSIAHQGCRKRLLDAGESEYSASLENSVTEYtPPVFIVHATDDKDVPVIHSLRYFNSIRDKGHHAEAHFFDKGGHGFGvS 245
Cdd:pfam00326 114 ERYMEWGNPWDNEEGYDYLSPYSPADNVKVY-PPLLLIHGLLDDRVPPWQSLKLVAALQRKGVPFLLLIFPDEGHGIG-K 191
                         170       180
                  ....*....|....*....|.
gi 545169223  246 GKNGYpieKWQSLLLEWLAEH 266
Cdd:pfam00326 192 PRNKV---EEYARELAFLLEY 209
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
53-264 6.30e-08

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 51.89  E-value: 6.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223  53 VLIIPG--GGYRRIVyereglDVGRWIAGQGYTAFIL---------------SYRMPSVNGYYSFADAKNALNFIsywAG 115
Cdd:COG0412   32 VVVLHEifGLNPHIR------DVARRLAAAGYVVLAPdlygrggpgddpdeaRALMGALDPELLAADLRAALDWL---KA 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223 116 MSERTFKSVGCMGFSAGGHLAgyithLHYeeeTSVRPDWMALI--YPvisldrsiahqgcrkRLLDAGESEYSASLensv 193
Cdd:COG0412  103 QPEVDAGRVGVVGFCFGGGLA-----LLA---AARGPDLAAAVsfYG---------------GLPADDLLDLAARI---- 155
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 545169223 194 teyTPPVFIVHATDDKDVPVIHSLRYFNSIRDKGHHAEAHFFDKGGHGFGVSGKNGYPI---EKWQSLLLEWLA 264
Cdd:COG0412  156 ---KAPVLLLYGEKDPLVPPEQVAALEAALAAAGVDVELHVYPGAGHGFTNPGRPRYDPaaaEDAWQRTLAFLA 226
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
53-265 2.08e-06

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 47.30  E-value: 2.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223  53 VLIIPGGGYRRIVYERegldVGRWIAGQGYTAFILSYR-----------MPSVNGYysFADAKNALNFISywagmsERTF 121
Cdd:COG2267   31 VVLVHGLGEHSGRYAE----LAEALAAAGYAVLAFDLRghgrsdgprghVDSFDDY--VDDLRAALDALR------ARPG 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223 122 KSVGCMGFSAGGHLAgyithLHYEEETSVRPDWMALIYPVISLDrsiAHQGCRKRLLdageseYSASLENSVTEYTPPVF 201
Cdd:COG2267   99 LPVVLLGHSMGGLIA-----LLYAARYPDRVAGLVLLAPAYRAD---PLLGPSARWL------RALRLAEALARIDVPVL 164
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 545169223 202 IVHATDDKDVPVIHSLRYFNSIrdkGHHAEAHFFDKGGHGFgvsgKNGYPIEKWQSLLLEWLAE 265
Cdd:COG2267  165 VLHGGADRVVPPEAARRLAARL---SPDVELVLLPGARHEL----LNEPAREEVLAAILAWLER 221
COG4099 COG4099
Predicted peptidase [General function prediction only];
199-267 1.75e-05

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 44.96  E-value: 1.75e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 545169223 199 PVFIVHATDDKDVPVIHSLRYFNSIRDKGhhAEAHF--FDKGGHGfgvSGKNGYPIEKwqslLLEWLAEHK 267
Cdd:COG4099  172 PVWIFHGAKDDVVPVEESRAMVEALKAAG--ADVKYteYPGVGHN---SWDPAYANPD----LYDWLFAQK 233
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
69-266 1.88e-03

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 38.77  E-value: 1.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223  69 EGLDVGRWIAGQGYTafILSYRMP------------SVNGYYsfADAKNALNFISywagmseRTFKSVGCMGFSAGGHLA 136
Cdd:COG1647   30 EMRPLAEALAKAGYT--VYAPRLPghgtspedllktTWEDWL--EDVEEAYEILK-------AGYDKVIVIGLSMGGLLA 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223 137 GYITHlHYEE-------ETSVR-PDWMALIYPVIS-LDRSIAHQGCRKRLLDAGESEYSASLENSVTE------------ 195
Cdd:COG1647   99 LLLAA-RYPDvaglvllSPALKiDDPSAPLLPLLKyLARSLRGIGSDIEDPEVAEYAYDRTPLRALAElqrlirevrrdl 177
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 545169223 196 --YTPPVFIVHATDDKDVPVIHSLRYFNSIRDKghHAEAHFFDKGGHGFGVsgknGYPIEKWQSLLLEWLAEH 266
Cdd:COG1647  178 pkITAPTLIIQSRKDEVVPPESARYIYERLGSP--DKELVWLEDSGHVITL----DKDREEVAEEILDFLERL 244
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
127-266 2.37e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 38.44  E-value: 2.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545169223 127 MGFSAGGHLAGYITHLHyeeetsvrPDW---MALIYPVIS-LDRSIAHQGCRKRLLDAG-ESEYSASLENSVTEYTPPVF 201
Cdd:COG0596   94 VGHSMGGMVALELAARH--------PERvagLVLVDEVLAaLAEPLRRPGLAPEALAALlRALARTDLRERLARITVPTL 165
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 545169223 202 IVHATDDKDVPVIHSLRYFNSIRdkghHAEAHFFDKGGHGFgvsgkngyPIEKWQ---SLLLEWLAEH 266
Cdd:COG0596  166 VIWGEKDPIVPPALARRLAELLP----NAELVVLPGAGHFP--------PLEQPEafaAALRDFLARL 221
YpfH COG0400
Predicted esterase [General function prediction only];
198-241 4.54e-03

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 37.19  E-value: 4.54e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 545169223 198 PPVFIVHATDDKDVPVIHSLRYFNSIRDKGHHAEAHFFDkGGHG 241
Cdd:COG0400  140 TPVFLAHGTQDPVIPVERAREAAEALEAAGADVTYREYP-GGHE 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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