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Conserved domains on  [gi|545255658|ref|WP_021551810|]
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MULTISPECIES: type II toxin-antitoxin system HigB family toxin [Enterobacteriaceae]

Protein Classification

type II toxin-antitoxin system HigB family toxin( domain architecture ID 10008707)

type II toxin-antitoxin (TA) system HigB family toxin similar to Escherichia coli mRNA interferase HigB, the toxin component of the HigB-HigA TA system; induced by amino acid starvation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HigB COG4680
mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB ...
 3-90 3.82e-52

mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB toxin-antitoxin module [Translation, ribosomal structure and biogenesis, Defense mechanisms];


:

Pssm-ID: 443716  Cd Length: 89  Bit Score: 158.00  E-value: 3.82e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545255658   3 IISVKTLRDFWAKNPDAEQPLKAWVDEATKADWKNPAEIKEQYRTASILKNRRVVFNIKGNDYRLIVAIAYQRGWMFVKF 82
Cdd:COG4680    2 IISRKTLREFWEKHPDAEQALDAWYREAKKADWKNPADLKKTFPSADIVGNNRVVFNIKGNKYRLIVAINYERQIVYIKF 81


                 ....*...
gi 545255658  83 IGTHKEYD 90
Cdd:COG4680   82 IGTHAEYD 89
 
Name Accession Description Interval E-value
HigB COG4680
mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB ...
 3-90 3.82e-52

mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB toxin-antitoxin module [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443716  Cd Length: 89  Bit Score: 158.00  E-value: 3.82e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545255658   3 IISVKTLRDFWAKNPDAEQPLKAWVDEATKADWKNPAEIKEQYRTASILKNRRVVFNIKGNDYRLIVAIAYQRGWMFVKF 82
Cdd:COG4680    2 IISRKTLREFWEKHPDAEQALDAWYREAKKADWKNPADLKKTFPSADIVGNNRVVFNIKGNKYRLIVAINYERQIVYIKF 81


                 ....*...
gi 545255658  83 IGTHKEYD 90
Cdd:COG4680   82 IGTHAEYD 89
HigB_toxin pfam09907
HigB_toxin, RelE-like toxic component of a toxin-antitoxin system; HigB_toxin is a family of ...
 19-91 1.37e-38

HigB_toxin, RelE-like toxic component of a toxin-antitoxin system; HigB_toxin is a family of RelE-like prokaryotic proteins that function as mRNA interferases. HigB cleaves translated mRNA only, and cleavage depended on translation of the target RNAs. HigB belongs to the RelE super-family of RNases. The toxin-antitoxin gene-pair is induced by environmental stress factors.


Pssm-ID: 462925  Cd Length: 73  Bit Score: 123.35  E-value: 1.37e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 545255658   19 AEQPLKAWVDEATKADWKNPAEIKEQYRTASILKNRRVVFNIKGNDYRLIVAIAYQRGWMFVKFIGTHKEYDA 91
Cdd:pfam09907   1 AEQALEAWYREVKKAEWKSPADVKAVFPSADIVGNNRVVFNIGGNKYRLIVAIDYERQKVYIKFIGTHAEYDK 73
 
Name Accession Description Interval E-value
HigB COG4680
mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB ...
 3-90 3.82e-52

mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB toxin-antitoxin module [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443716  Cd Length: 89  Bit Score: 158.00  E-value: 3.82e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545255658   3 IISVKTLRDFWAKNPDAEQPLKAWVDEATKADWKNPAEIKEQYRTASILKNRRVVFNIKGNDYRLIVAIAYQRGWMFVKF 82
Cdd:COG4680    2 IISRKTLREFWEKHPDAEQALDAWYREAKKADWKNPADLKKTFPSADIVGNNRVVFNIKGNKYRLIVAINYERQIVYIKF 81


                 ....*...
gi 545255658  83 IGTHKEYD 90
Cdd:COG4680   82 IGTHAEYD 89
HigB_toxin pfam09907
HigB_toxin, RelE-like toxic component of a toxin-antitoxin system; HigB_toxin is a family of ...
 19-91 1.37e-38

HigB_toxin, RelE-like toxic component of a toxin-antitoxin system; HigB_toxin is a family of RelE-like prokaryotic proteins that function as mRNA interferases. HigB cleaves translated mRNA only, and cleavage depended on translation of the target RNAs. HigB belongs to the RelE super-family of RNases. The toxin-antitoxin gene-pair is induced by environmental stress factors.


Pssm-ID: 462925  Cd Length: 73  Bit Score: 123.35  E-value: 1.37e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 545255658   19 AEQPLKAWVDEATKADWKNPAEIKEQYRTASILKNRRVVFNIKGNDYRLIVAIAYQRGWMFVKFIGTHKEYDA 91
Cdd:pfam09907   1 AEQALEAWYREVKKAEWKSPADVKAVFPSADIVGNNRVVFNIGGNKYRLIVAIDYERQKVYIKFIGTHAEYDK 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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