|
Name |
Accession |
Description |
Interval |
E-value |
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
3-449 |
8.59e-80 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 254.62 E-value: 8.59e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 3 RLSITIRLTLLFILLLSVAGAGIVWTLYNGLASELKWRDDTTLINRTAQIKQLLIDGVNPDT----LPVYFNRMMDVSQD 78
Cdd:TIGR01386 1 PRSLTLRLALLFAAVTALVFALSGFMLYSSLERHFEERDREELQGKLEQVRRFLRDPADLDEdikrLQEKIDDLLVGHSD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 79 I--LIIHGDG--------INKIVNRTNVSDDMLNNIPAtetISAPGIYRSIINDteIDALQININeiSPVLTVTVAKLAS 148
Cdd:TIGR01386 81 LalSILNPDGrllferaqGAALVPAVAANDALLELDQA---DAKMTHYRSILRS--VAALPGGKG--RKPVQITVALDIN 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 149 ARHNMLEQYKINSIIICIVAIILCSVLSPLLIRTGLREIKKLSGVTEALNYNDTREPVEVSALPSELKPLGQALNKMHHA 228
Cdd:TIGR01386 154 AHTHLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 229 LVKDFERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIGELENISRLTENILFLARADKNNVLVKLD 308
Cdd:TIGR01386 234 LEDAFQRLSQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGQLALERV 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 309 LLSLNKEVGNLLDYLEYLSDEKEIRFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSLIHItSFLDFNGYLNIDIAS 388
Cdd:TIGR01386 314 RLDLAAELAKVAEYFEPLAEERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITV-RIERRSDEVRVSVSN 392
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 545289548 389 PGKKINES--EKIFRRFWRGDNSRH--SAGQGLGLSLVKAIAELHGGSATYHYINENNVFRIALP 449
Cdd:TIGR01386 393 PGPGIPPEhlSRLFDRFYRVDPARSnsGEGTGLGLAIVRSIMEAHGGRASAESPDGKTRFILRFP 457
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
221-449 |
7.04e-46 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 158.92 E-value: 7.04e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 221 ALNKMHHALVKDFERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIG-ELENISRLTENILFLARAD 299
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIReSAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 300 KNNVLVKLDLLSLNKEVGNLLDYLEYLSDEKEIRFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSLIHITSFL 376
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElplVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545289548 377 DfNGYLNIDIASPGKKINES--EKIFRRFWRGDNSRHSAGQGLGLSLVKAIAELHGGSATYHYINEN-NVFRIALP 449
Cdd:COG2205 161 E-GDGVRISVSDNGPGIPEEelERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGgTTFTVTLP 235
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
175-449 |
8.15e-46 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 161.61 E-value: 8.15e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 175 LSPLLIRTGLREIKKLSGVTEALNYNDTREPVEVSALPSELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINAL 254
Cdd:COG0642 49 LLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAI 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 255 LGQNQVTLSQTRsiAEYQKTIAGNIGELENISRLTENILFLARADKNNVLVKLDLLSLNKEVGNLLDYLEYLSDEKEIRF 334
Cdd:COG0642 129 RGYLELLLEELD--EEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIEL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 335 KVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDfNGYLNIDIASPGKKINES--EKIFRRFWRGDNS 409
Cdd:COG0642 207 ELDLPDDlptVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRRE-GDRVRISVEDTGPGIPPEdlERIFEPFFRTDPS 285
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 545289548 410 RHSAGQGLGLSLVKAIAELHGGSATYHY-INENNVFRIALP 449
Cdd:COG0642 286 RRGGGTGLGLAIVKRIVELHGGTIEVESePGKGTTFTVTLP 326
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-449 |
4.59e-41 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 141.76 E-value: 4.59e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 349 LQRMLSNLIVNAIRYSPEKSLIHITSFLDfNGYLNIDIASPGKKINES--EKIFRRFWRGDNSRHSAGQGLGLSLVKAIA 426
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLT-DDVVNIMFKNPSSHPLDFklEKLFERFYRGDNSRNTEGAGLGLSIAKAII 79
|
90 100
....*....|....*....|...
gi 545289548 427 ELHGGSATYHYINENNVFRIALP 449
Cdd:cd16923 80 ELHGGSASAEYDDNHDLFKVRLP 102
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
178-432 |
6.85e-41 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 152.23 E-value: 6.85e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 178 LLIRTGLREIKKLSGVTEALNYNDTREPVEVSALPSELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINALLGQ 257
Cdd:PRK09835 204 LAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQ 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 258 NQVTLSQTRSIAEYQKTIAGNIGELENISRLTENILFLARADKNNVLVKLDLLSLNKEVGNLLDYLEYLSDEKEIRFKVE 337
Cdd:PRK09835 284 TEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFV 363
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 338 CNQ-QIFADKILLQRMLSNLIVNAIRYSP--EKSLIHITSFLDFngyLNIDIASPGKKINESE--KIFRRFWRGDNSRHS 412
Cdd:PRK09835 364 GDPcQVAGDPLMLRRAISNLLSNALRYTPagEAITVRCQEVDHQ---VQLVVENPGTPIAPEHlpRLFDRFYRVDPSRQR 440
|
250 260
....*....|....*....|..
gi 545289548 413 AGQ--GLGLSLVKAIAELHGGS 432
Cdd:PRK09835 441 KGEgsGIGLAIVKSIVVAHKGT 462
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
228-449 |
5.35e-40 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 147.78 E-value: 5.35e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 228 ALVKDFERLSQFADDLAHELRTPINALLGQNQVTLSQ-TRSIAEYQKTIAGNIGELENISRLTENILFLARADKNNVLVK 306
Cdd:COG5002 157 ELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGaADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLE 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 307 LDLLSLNKEVGNLLDYLEYLSDEKEIRFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDfNGYLN 383
Cdd:COG5002 237 KEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDpllVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREE-DDQVR 315
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 545289548 384 IDIASPGKKINES--EKIFRRFWRGDNS--RHSAGQGLGLSLVKAIAELHGGSATYHY-INENNVFRIALP 449
Cdd:COG5002 316 ISVRDTGIGIPEEdlPRIFERFYRVDKSrsRETGGTGLGLAIVKHIVEAHGGRIWVESePGKGTTFTITLP 386
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
108-431 |
1.72e-24 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 105.29 E-value: 1.72e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 108 ETISAPGIYRSI-INDTEIDALQInineiSPVLTVTvaklASARHNMLEQYKiNSIIICIVAIILCSVLSPLLIRTGLRE 186
Cdd:NF012163 121 DPVSDDGTRRPIlVNGQEVGALGA-----SPVERLT----RNTDINFDSQQK-RASWLIVALALLLAALAAFLLARGLLA 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 187 -IKKLSGVTEALNYNDTREPVEVSAlPSELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINALLGQNQVTLSQT 265
Cdd:NF012163 191 pVKRLVEATHRLAAGDYTTRVTPTS-NDELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQDGI 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 266 RSIAeyQKTIAGNIGELENISRLTENILFLARADKNNV---LVKLDLLS-LNKEVGNLLDYLEylSDEKEIRFKVECNQQ 341
Cdd:NF012163 270 RKFT--PESLDSLQAEVGTLTKLVDDLHDLSMSDEGALayqKASVDLVPlLEVEGGAFRERFA--SAGLELEVSLPDSSL 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 342 IFADKILLQRMLSNLIVNAIRYSPEKSLIHI-TSFLDFNGYLNIDIASPGKKINESEKIFRRFWRGDNSRH--SAGQGLG 418
Cdd:NF012163 346 VFGDRDRLMQLFNNLLENSLRYTDSGGSLHIsASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNraSGGSGLG 425
|
330
....*....|...
gi 545289548 419 LSLVKAIAELHGG 431
Cdd:NF012163 426 LAISLNIVQAHGG 438
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
185-436 |
2.47e-23 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 102.23 E-value: 2.47e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 185 REIKKLSGVTEALNYNdtrEPVEVSAL-PSELKPLGQALNKMHHALV-KDF-ERLSQfadDLAHELRTPINALLGQNQvt 261
Cdd:PRK11100 208 RSIRRLTRYADAVTEG---KPVPLPKLgSSELRELAQALESMRVKLEgKAYvEQYVQ---TLTHELKSPLAAIRGAAE-- 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 262 LSQTRSIAEYQKTIAGNI-GELENISRLTENILFLARADKNNVLVKLDLLSLNKEVGNLLDYLEYLSDEKEIRFKVEC-N 339
Cdd:PRK11100 280 LLQEDPPPEDRARFTGNIlTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPdD 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 340 QQIFADKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDfNGYLNIDIASPGKKINES--EKIFRRFW---RGDNSRHSAG 414
Cdd:PRK11100 360 ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVD-GEQVALSVEDQGPGIPDYalPRIFERFYslpRPANGRKSTG 438
|
250 260
....*....|....*....|..
gi 545289548 415 qgLGLSLVKAIAELHGGSATYH 436
Cdd:PRK11100 439 --LGLAFVREVARLHGGEVTLR 458
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
349-436 |
1.50e-22 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 91.90 E-value: 1.50e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 349 LQRMLSNLIVNAIRYSPEKSLIHITSFLDFNGYLnIDIASPGKKINES--EKIFRRFWRGDNSRHSAGQGLGLSLVKAIA 426
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVV-LEVEDNGPGIPEEdlERIFERFYRGDKSREGGGTGLGLAIVRRIV 79
|
90
....*....|
gi 545289548 427 ELHGGSATYH 436
Cdd:cd00075 80 EAHGGRITVE 89
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
344-449 |
6.57e-22 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 90.40 E-value: 6.57e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 344 ADKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDfNGYLNIDIASPGKKINES--EKIFRRFWRGD-NSRHSAGQGLGLS 420
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERD-GDHVEITVEDNGPGIPPEdlEKIFEPFFRTDkRSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|..
gi 545289548 421 LVKAIAELHGGsaTYHYINENN---VFRIALP 449
Cdd:smart00387 80 IVKKLVELHGG--EISVESEPGggtTFTITLP 109
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
178-435 |
2.63e-21 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 95.87 E-value: 2.63e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 178 LLIRTGL--REIKKLSGVTEALNYN--DTREPVEVSALPSELKPLGQALN----KMHHALVKdfERlsQFADDLAHELRT 249
Cdd:PRK10337 175 LIILMVLlgRELAPLKKLALALRMRdpDSETPLNATGVPSEVRPLVEALNqlfaRTHAMMVR--ER--RFTSDAAHELRS 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 250 PINALLGQNQVT-LSQTRsiAEYQKTIAGNIGE-LENISRLTENILFLARADKNNVLVKLDLLSLNKEVGNLLDYLEYLS 327
Cdd:PRK10337 251 PLAALKVQTEVAqLSDDD--PQARKKALLQLHAgIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDIYHTA 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 328 DEKEIRFKVECNqqifADKI-------LLQRMLSNLIVNAIRYSPEKSLIHITsfLDFNGYLNIDiASPGKKINESEKIF 400
Cdd:PRK10337 329 QQAGIDVRLTLN----AHPVirtgqplLLSLLVRNLLDNAIRYSPQGSVVDVT--LNARNFTVRD-NGPGVTPEALARIG 401
|
250 260 270
....*....|....*....|....*....|....*
gi 545289548 401 RRFWRgDNSRHSAGQGLGLSLVKAIAELHGGSATY 435
Cdd:PRK10337 402 ERFYR-PPGQEATGSGLGLSIVRRIAKLHGMNVSF 435
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
213-432 |
3.79e-21 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 95.06 E-value: 3.79e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 213 SELKPLGQALNKMH---HALVKDFErlsQFADDLAHELRTPINALlgQNQVTLSQTRSIAEyQKTIAGNIGELENisrLT 289
Cdd:PRK10604 189 SSLERLGVAFNQMAdniNALIASKK---QLIDGIAHELRTPLVRL--RYRLEMSDNLSAAE-SQALNRDIGQLEA---LI 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 290 ENILFLARADKNNVLVKLDLLSLNKEVGNLLDYLEYLSDEKEIRFKVECNQQIFA-DKILLQRMLSNLIVNAIRYSPEKS 368
Cdd:PRK10604 260 EELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGAlDMRLMERVLDNLLNNALRYAHSRV 339
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545289548 369 LIHITsFLDFNGYLNIDIASPGKKINESEKIFRRFWRGDNSRHSA--GQGLGLSLVKAIAELHGGS 432
Cdd:PRK10604 340 RVSLL-LDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRAtgGCGLGLAIVHSIALAMGGS 404
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
243-451 |
9.00e-21 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 95.49 E-value: 9.00e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 243 LAHELRTPINALLGQNQVTlsqTRSIAEYQKTIAGNIGELE----NISRLTENILFLARADKNNVLVKLDLLSLNKEVGN 318
Cdd:PRK10490 671 LSHDLRTPLTVLFGQAEIL---TLDLASEGSPHARQASEIRqqvlNTTRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGS 747
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 319 LLDYLEYLSDEKEIRFKVECNQQ-IFADKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDfNGYLNIDI--ASPGKKINE 395
Cdd:PRK10490 748 ALQMLEPGLSGHPINLSLPEPLTlIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVE-GERLQLDVwdNGPGIPPGQ 826
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 545289548 396 SEKIFRRFWRGDNSRHSAGQGLGLSLVKAIAELHGGSATYhyinENN-----VFRIALPQK 451
Cdd:PRK10490 827 EQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWA----ENRpeggaCFRVTLPLE 883
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
214-451 |
1.22e-20 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 94.47 E-value: 1.22e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 214 ELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINALLGQNQVTLSQTRS-----IAEYQKTIAGNIgelENISRL 288
Cdd:COG4251 260 ELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYGDkldeeGREYLERIRDAA---ERMQAL 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 289 TENILFLARADKNNVlvKLDLLSLNKEVGNLLDYLEYLSDEKEIRFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKS 368
Cdd:COG4251 337 IDDLLAYSRVGRQEL--EFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGE 414
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 369 --LIHITSFLDfNGYLNIDIASPGKKINE--SEKIFRRFWRGDNSRHSAGQGLGLSLVKAIAELHGGSATYHY-INENNV 443
Cdd:COG4251 415 ppRIEIGAERE-GGEWVFSVRDNGIGIDPeyAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESePGEGAT 493
|
....*...
gi 545289548 444 FRIALPQK 451
Cdd:COG4251 494 FYFTLPKA 501
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-432 |
5.87e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 84.76 E-value: 5.87e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 339 NQQIFADKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDFNGYLNIDIASPGKKINESEKIFRRFWRGDnSRHSAGQGLG 418
Cdd:cd16940 4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYRSD-GQNYGGSGLG 82
|
90
....*....|....
gi 545289548 419 LSLVKAIAELHGGS 432
Cdd:cd16940 83 LSIVKRIVELHGGQ 96
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
243-449 |
8.82e-19 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 88.10 E-value: 8.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 243 LAHELR---TPI--NALLGQNQVTLSQTRSIAEYQKTIAGNIGELENISRLTENILFLARADKNNvLVKLDLLSLnkeVG 317
Cdd:COG5000 208 IAHEIKnplTPIqlSAERLRRKLADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQ-LEPVDLNEL---LR 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 318 NLLDYLEYLSDEKEIRFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDfNGYLNIDIASPGKKIN 394
Cdd:COG5000 284 EVLALYEPALKEKDIRLELDLDPDlpeVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRRE-DGRVRIEVSDNGPGIP 362
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 395 ES--EKIFRRFwrgdNSRHSAGQGLGLSLVKAIAELHGGSATYHyiNENN---VFRIALP 449
Cdd:COG5000 363 EEvlERIFEPF----FTTKPKGTGLGLAIVKKIVEEHGGTIELE--SRPGggtTFTIRLP 416
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
344-449 |
2.66e-18 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 80.10 E-value: 2.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 344 ADKILLQRMLSNLIVNAIRYSPEKSLIHITsfLDFNGYLNIDIASPGKKINES--EKIFRRFWRGDNSRHSaGQGLGLSL 421
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVT--LSEGGELTLTVEDNGIGIPPEdlPRIFEPFSTADKRGGG-GTGLGLSI 77
|
90 100
....*....|....*....|....*....
gi 545289548 422 VKAIAELHGGSATYHY-INENNVFRIALP 449
Cdd:pfam02518 78 VRKLVELLGGTITVESePGGGTTVTLTLP 106
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
175-431 |
3.86e-18 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 85.40 E-value: 3.86e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 175 LSPLLIRTGLREIkklSGVTEALNyndtrepvevsalpselkplgQALNKMHHALvkDFERLsqFADDLAHELRTPINA- 253
Cdd:PRK10755 104 LTPIAIHSSTLEI---EAVTSALN---------------------QLVSRLTSTL--DQERL--FTADVAHELRTPLAGi 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 254 -----LLGQNQVTLSQTRsiaeyqktiagnIGELENISRLTENILFLARADKNNVLVKLDLLSLNKEV-GNLLDYLEYLS 327
Cdd:PRK10755 156 rlhleLLEKQHHIDVAPL------------IARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKLLEDViLPSQDELSEML 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 328 DEKEIRFKVECNQQIFA---DKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDfNGYLNIDIASPGKKINESE-----KI 399
Cdd:PRK10755 224 EQRQQTLLLPESAADITvqgDATLLRLLLRNLVENAHRYSPEGSTITIKLSQE-DGGAVLAVEDEGPGIDESKcgelsKA 302
|
250 260 270
....*....|....*....|....*....|..
gi 545289548 400 FRRFwrgdNSRHSaGQGLGLSLVKAIAELHGG 431
Cdd:PRK10755 303 FVRM----DSRYG-GIGLGLSIVSRITQLHHG 329
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
201-431 |
3.82e-17 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 82.26 E-value: 3.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 201 DTREPVE-VSALPSELK------PLGqalNKMHHALVKDFERLSQ-------FADDLAHELRTPINALLGQNQvTLSQTR 266
Cdd:TIGR02966 68 RFSEPLElPSPINSERVleiriaPYG---EEQKLLVARDVTRLRRleqmrrdFVANVSHELRTPLTVLRGYLE-TLADGP 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 267 SI--AEYQKTIAGNIGELENISRLTENILFLAR---ADKNNVLVKLDLLSLnkeVGNLLDYLEYLSDEKE--IRFKVECN 339
Cdd:TIGR02966 144 DEdpEEWNRALEIMLEQSQRMQSLVEDLLTLSRlesAASPLEDEPVDMPAL---LDHLRDEAEALSQGKNhqITFEIDGG 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 340 QQIFADKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDFNGyLNIDIASPGKKINESE--KIFRRFWRGD--NSRHSAGQ 415
Cdd:TIGR02966 221 VDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGG-AEFSVTDTGIGIAPEHlpRLTERFYRVDksRSRDTGGT 299
|
250
....*....|....*.
gi 545289548 416 GLGLSLVKAIAELHGG 431
Cdd:TIGR02966 300 GLGLAIVKHVLSRHHA 315
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
214-449 |
4.34e-17 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 83.54 E-value: 4.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 214 ELKPLGQALNKMHHAL------VKDFERLSQ-FADDLAHELRTPINA------LLGQNQVTL-SQTRSIAEYQKTiagni 279
Cdd:NF040691 242 DLARLARSFNQMADSLqrqirqLEELSRLQQrFVSDVSHELRTPLTTirmaadVIHDSRDDFdPATARSAELLHT----- 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 280 gELENISRLTENILFLARADKNNVLVKLDLLSLNKEVGNLLDYLEYLSDEKEIRFKVECNQQIF---ADKILLQRMLSNL 356
Cdd:NF040691 317 -ELDRFESLLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGTPVvaeVDPRRVERVLRNL 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 357 IVNAIRYSpEKSLIHITsfLDFNG---YLNIDIASPGKKINESEKIFRRFWRGDNSR--HSAGQGLGLSLVKAIAELHGG 431
Cdd:NF040691 396 VVNAIEHG-EGKPVVVT--VAQDDtavAVTVRDHGVGLKPGEVALVFDRFWRADPARarTTGGTGLGLAIALEDARLHGG 472
|
250
....*....|....*....
gi 545289548 432 SATYH-YINENNVFRIALP 449
Cdd:NF040691 473 WLEAWgRPGQGSQFRLTLP 491
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
178-432 |
1.26e-16 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 81.60 E-value: 1.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 178 LLIRTGLREIKKLSGVTEALNYNDTREPVEVSAlPSELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINALLG- 256
Cdd:PRK10549 183 LLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTS-RDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGe 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 257 ----QNQVTLSQTRSIAEYQktiagniGELENISRLTENILFLARADKNNvlvkldlLSLNKEVGNLLDYLE-------- 324
Cdd:PRK10549 262 leaiQDGVRKFTPESVASLQ-------AEVGTLTKLVDDLHQLSLSDEGA-------LAYRKTPVDLVPLLEvaggafre 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 325 -YLSDEKEIRFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDFNGY-LNIDIASPGKKINESEKIFRR 402
Cdd:PRK10549 328 rFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLrLTFADSAPGVSDEQLQKLFER 407
|
250 260 270
....*....|....*....|....*....|..
gi 545289548 403 FWRGDNSRH--SAGQGLGLSLVKAIAELHGGS 432
Cdd:PRK10549 408 FYRTEGSRNraSGGSGLGLAICLNIVEAHNGR 439
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
212-450 |
3.39e-15 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 76.57 E-value: 3.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 212 PSELKPLGQALNKMHHALVKDFERLSQFADDLAHELRTPINALLGQNQVTLSqtrSIAEYQKTIAGN-IGELENISRLTE 290
Cdd:NF012226 114 SAEISELMHNFNDMAQKLESSVKNAQVWNAAIAHELRTPITILQGRLQGILD---GVFEPDPALFKSlLNQVEGLSHLVE 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 291 NILFLARADKNNVLVKLDLLSLNKEVGNLLDYLEYLSDEKEIRFKVE-CNQQIFADKILLQRMLSNLIVNAIRYSpEKSL 369
Cdd:NF012226 191 DLRTLSLVENQQLRLNYESVDLKDSIEKVLKMFEDRLEQAQLTIVLNlTATPVFCDRRRIEQVLIALIDNAIRYA-NAGK 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 370 IHITSFLDFNGY-LNIDIASPGKKINESEKIFRRFWRGDNSRHSA--GQGLGLSLVKAIAELHGGSATYHYINENNVFRI 446
Cdd:NF012226 270 LKISSSVIQDDWiLQIEDEGPGIAEEYQQDLFNPFFRLEQSRNKEfgGTGLGLAVVHAIVIAHKGSIEYSNSQGNSVFTI 349
|
....
gi 545289548 447 ALPQ 450
Cdd:NF012226 350 KLPA 353
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
207-449 |
5.79e-15 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 75.99 E-value: 5.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 207 EVSALPSELKPLGQALNKMHHAlvkdfERLS---QFADDLAHELRTPINALLGQNQV---TLSQTRSIAEYQKTIAGNIG 280
Cdd:COG4191 115 DITELERAEEELRELQEQLVQS-----EKLAalgELAAGIAHEINNPLAAILGNAELlrrRLEDEPDPEELREALERILE 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 281 ELENISRLTENILFLARADKnnvlVKLDLLSLNKEVGNLLDYLEYLSDEKEIRFKVECNQ---QIFADKILLQRMLSNLI 357
Cdd:COG4191 190 GAERAAEIVRSLRAFSRRDE----EEREPVDLNELIDEALELLRPRLKARGIEVELDLPPdlpPVLGDPGQLEQVLLNLL 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 358 VNAIRYSPEKS--LIHITSFLDfNGYLNIDIASPGKKINES--EKIFRRFW----RGDnsrhsaGQGLGLSLVKAIAELH 429
Cdd:COG4191 266 INAIDAMEEGEggRITISTRRE-GDYVVISVRDNGPGIPPEvlERIFEPFFttkpVGK------GTGLGLSISYGIVEKH 338
|
250 260
....*....|....*....|....*
gi 545289548 430 GGSATYhyinENN-----VFRIALP 449
Cdd:COG4191 339 GGRIEV----ESEpgggtTFTITLP 359
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-449 |
1.35e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 69.28 E-value: 1.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 349 LQRMLSNLIVNAIRYSPEKSLIHITSFLDFnGYLNIDIASPGKKINESEKIFRRFWRGDNSR--HSAGQGLGLSLVKAIA 426
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDGDQ-WTITITDDGPGVPEDQLEQIFLPFYRVDSARdrESGGTGLGLAIAERAI 79
|
90 100
....*....|....*....|....*...
gi 545289548 427 ELHGGSAtyhyINENN-----VFRIALP 449
Cdd:cd16949 80 EQHGGKI----KASNRkpgglRVRIWLP 103
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
212-432 |
3.52e-14 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 74.20 E-value: 3.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 212 PSELKPLGQALNKMHHAL---VKDFERLsqfADDLAHELRTPI------NALLgqnqvtlsqTRSIAEYQktiagnigEL 282
Cdd:PRK09470 219 PQEFRQAGASFNQMVTALermMTSQQRL---LSDISHELRTPLtrlqlaTALL---------RRRQGESK--------EL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 283 ENI----SRLTENI---LFLARADKNNVLVKlDLLSLNKEVGNLLDYLEYLSDEKEIRFKVECNQQ---IFADKILLQRM 352
Cdd:PRK09470 279 ERIeteaQRLDSMIndlLVLSRNQQKNHLER-ETFKANSLWSEVLEDAKFEAEQMGKSLTVSAPPGpwpINGNPNALASA 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 353 LSNLIVNAIRYSpeKSLIHITSFLDFNG-YLNIDIASPGKKINESEKIFRRFWRGDNSR--HSAGQGLGLSLVKAIAELH 429
Cdd:PRK09470 358 LENIVRNALRYS--HTKIEVAFSVDKDGlTITVDDDGPGVPEEEREQIFRPFYRVDEARdrESGGTGLGLAIVENAIQQH 435
|
...
gi 545289548 430 GGS 432
Cdd:PRK09470 436 RGW 438
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
243-431 |
4.74e-14 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 73.45 E-value: 4.74e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 243 LAHELRTPINAL--------LGQNQ-VTLSQTRSIAEYQKTIAGnigELENISRLTENILFLARAdKNNVL----VKLDL 309
Cdd:PRK09303 158 LAHDLRTPLTAAslaletleLGQIDeDTELKPALIEQLQDQARR---QLEEIERLITDLLEVGRT-RWEALrfnpQKLDL 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 310 LSLNKEVgnLLDYLEYLSdEKEIRFKVECNQQI---FADKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDFNGYLNIDI 386
Cdd:PRK09303 234 GSLCQEV--ILELEKRWL-AKSLEIQTDIPSDLpsvYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLHRTTQKVQVSI 310
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 545289548 387 AS--PGKKINESEKIFRRFWRGDNSRHSAGQGLGLSLVKAIAELHGG 431
Cdd:PRK09303 311 CDtgPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYG 357
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-434 |
1.07e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 66.70 E-value: 1.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 349 LQRMLSNLIVNAIRYSpeKSLIHITSFLDFNgYLNIDIASPGKKINESE--KIFRRFWRGDNSRHSAGQGLGLSLVKAIA 426
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGN-RTRIQVLDNGPGIAPEEvdELFQPFYRGDNARGTSGTGLGLAIVQRIS 77
|
....*...
gi 545289548 427 ELHGGSAT 434
Cdd:cd16950 78 DAHGGSLT 85
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
344-449 |
1.22e-13 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 67.13 E-value: 1.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 344 ADKIllQRMLSNLIVNAIRYSPEKSLIH-ITSFLDFNGYL-NIDIASPGKKINESEKIFRRFWRG--DNSRHSAGQGLGL 419
Cdd:cd16925 2 AEKY--ERVVLNLLSNAFKFTPDGGRIRcILEKFRLNRFLlTVSDSGPGIPPNLREEIFERFRQGdgSSTRAHGGTGLGL 79
|
90 100 110
....*....|....*....|....*....|.
gi 545289548 420 SLVKAIAELHGGSATYHYINENN-VFRIALP 449
Cdd:cd16925 80 SIVKEFVELHGGTVTVSDAPGGGaLFQVELP 110
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-434 |
2.68e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 65.95 E-value: 2.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 345 DKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDFNgYLNIDIASPGKKINES--EKIFRRFWRGDNSRHSAGQ-GLGLSL 421
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEE-YLYFEIWDNGHGFSEQdlKKALELFYRDDTSRRSGGHyGMGLYI 79
|
90
....*....|...
gi 545289548 422 VKAIAELHGGSAT 434
Cdd:cd16975 80 AKNLVEKHGGSLI 92
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-432 |
4.01e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 65.56 E-value: 4.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 345 DKILLQRMLSNLIVNAIRYSPEKSLIHI-TSFLDFNGYLNIDIASPGKKINESEKIFRRFWRGDNSRH--SAGQGLGLSL 421
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIrAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNraSGGSGLGLAI 80
|
90
....*....|.
gi 545289548 422 VKAIAELHGGS 432
Cdd:cd16946 81 CHNIALAHGGT 91
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-448 |
6.62e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 65.23 E-value: 6.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 334 FKVECN---QQIFA--DKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDfNGYLNIDIASPGKKINES--EKIFRRFWRG 406
Cdd:cd16947 1 FQVEINipdRPIYAnaNTEALQRILKNLISNAIKYGSDGKFLGMTLRED-EKHVYIDIWDKGKGISETekDHVFERLYTL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 545289548 407 DNSRHSA--GQGLGLSLVKAIAELHGGSATYH-YINENNVFRIAL 448
Cdd:cd16947 80 EDSRNSAkqGNGLGLTITKRLAESMGGSIYVNsKPYEKTVFTVTL 124
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
234-431 |
6.99e-13 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 70.38 E-value: 6.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 234 ERLS---QFADDLAHELRTPINALLGQNQVTLSQTRSIaEYQKTIAGNIGELENISRLTENILFLARADKnnvlVKLDLL 310
Cdd:PRK11360 385 ERLAalgELVAGVAHEIRNPLTAIRGYVQIWRQQTSDP-PSQEYLSVVLREVDRLNKVIDQLLEFSRPRE----SQWQPV 459
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 311 SLNKEVGNLLDYLEYLSDEKEIRFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDFNGYLNIDIA 387
Cdd:PRK11360 460 SLNALVEEVLQLFQTAGVQARVDFETELDNElppIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQVAVSIE 539
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 545289548 388 SPGKKINES--EKIFRRFWrgdnSRHSAGQGLGLSLVKAIAELHGG 431
Cdd:PRK11360 540 DNGCGIDPEllKKIFDPFF----TTKAKGTGLGLALSQRIINAHGG 581
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
329-432 |
6.17e-12 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 67.24 E-value: 6.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 329 EKEIRFKV-ECNQQIFADKILLQRMLSNLIVNAIRYSpeKSLIHITSFLDFNgYLNIDIASPGKKINES--EKIFRRFWR 405
Cdd:PRK09467 311 EREIETALqPGPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEGK-RAWFQVEDDGPGIPPEqlKHLFQPFTR 387
|
90 100
....*....|....*....|....*..
gi 545289548 406 GDNSRHSAGQGLGLSLVKAIAELHGGS 432
Cdd:PRK09467 388 GDSARGSSGTGLGLAIVKRIVDQHNGK 414
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
245-431 |
1.12e-11 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 66.70 E-value: 1.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 245 HELRTP-------INAL---------LGQN--QVTLSQT-RSIaeyqktiagnigelenisRLTENILFLARADKNNVLV 305
Cdd:NF033092 381 HELRTPlttmrsyLEALadgawkdpeLAPRflGVTQNETeRMI------------------RLVNDLLQLSRMDSKDYKL 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 306 KLDLLSLNKEVGNLLDYLEYLSDEKEIRFKVEC-NQQIFA----DKIllQRMLSNLIVNAIRYSPEKSLIHItSFLDFNG 380
Cdd:NF033092 443 NKEWVNFNEFFNYIIDRFEMILKNKNITFKREFpKRDLWVeidtDKI--TQVLDNIISNAIKYSPEGGTITF-RLLETHN 519
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 545289548 381 YLNIDIAS-----PGKKInesEKIFRRFWRGDN--SRHSAGQGLGLSLVKAIAELHGG 431
Cdd:NF033092 520 RIIISISDqglgiPKKDL---DKIFDRFYRVDKarSRKMGGTGLGLAIAKEVVEAHGG 574
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
236-449 |
1.39e-11 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 65.64 E-value: 1.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 236 LSQFADDLAHELRTPINALLGQNQVtLSQTRSIAEYQKTIAGNIGELENISRLTENILFLARADKnnvlVKLDLLSLNKE 315
Cdd:COG3852 135 VGELAAGLAHEIRNPLTGIRGAAQL-LERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRP----PEREPVNLHEV 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 316 VGNLLDYLEYLSDeKEIRFKVECNQ---QIFADKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDFN---------GYLN 383
Cdd:COG3852 210 LERVLELLRAEAP-KNIRIVRDYDPslpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQvtlgglrprLYVR 288
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 545289548 384 IDIASPGKKINES--EKIFRRFWrgdnSRHSAGQGLGLSLVKAIAELHGGSATYH-YINENNVFRIALP 449
Cdd:COG3852 289 IEVIDNGPGIPEEilDRIFEPFF----TTKEKGTGLGLAIVQKIVEQHGGTIEVEsEPGKGTTFRIYLP 353
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
239-423 |
8.25e-11 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 63.49 E-value: 8.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 239 FADdLAHELRTPINALLG-----QNQVTLSQTRSIA-----EYQKTIAGNIGELENISRLtENILFLARADKNNVLVKLD 308
Cdd:PRK11006 208 FAN-VSHELRTPLTVLQGylemmQDQPLEGALREKAlhtmrEQTQRMEGLVKQLLTLSKI-EAAPTIDLNEKVDVPMMLR 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 309 LLSlnKEVgnlldylEYLSDEK-EIRFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDFNG-YLNIDI 386
Cdd:PRK11006 286 VLE--REA-------QTLSQGKhTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGaEFSVED 356
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 545289548 387 ASPGkkInESEKIFR---RFWRGDN--SRHSAGQGLGLSLVK 423
Cdd:PRK11006 357 NGPG--I-APEHIPRlteRFYRVDKarSRQTGGSGLGLAIVK 395
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
234-297 |
1.34e-10 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 56.84 E-value: 1.34e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 545289548 234 ERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIGELENISRLTENILFLAR 297
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-433 |
2.60e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 57.44 E-value: 2.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 349 LQRMLSNLIVNAIRYSpeKSLIHItSFLDFNGYLNIDIASPGKKINES--EKIFRRFWRGDNSR--HSAGQGLGLSLVKA 424
Cdd:cd16939 1 MARALDNLLRNALRYA--HRTVRI-ALLVSGGRLTLIVEDDGPGIPAAarERVFEPFVRLDPSRdrATGGFGLGLAIVHR 77
|
....*....
gi 545289548 425 IAELHGGSA 433
Cdd:cd16939 78 VALWHGGHV 86
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
349-432 |
5.10e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 56.73 E-value: 5.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 349 LQRMLSNLIVNAIRYSPEKSL---IHITSFLDFNGYLNIDIASPGKKINESE--KIFRRFWRGDNS--RHSAGQGLGLSL 421
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVtlrVSLEEEEEDGVQLRFSVEDTGIGIPEEQqaRLFEPFSQADSSttRKYGGTGLGLAI 80
|
90
....*....|.
gi 545289548 422 VKAIAELHGGS 432
Cdd:cd16922 81 SKKLVELMGGD 91
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-441 |
1.59e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 55.16 E-value: 1.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 345 DKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDFNGyLNIDIASPGKKINES--EKIFRRFW---RGDNSRHSAGqgLGL 419
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEG-IELLVFDEGSGIPDYalNRVFERFYslpRPHSGQKSTG--LGL 77
|
90 100
....*....|....*....|..
gi 545289548 420 SLVKAIAELHGGSATYHYINEN 441
Cdd:cd16945 78 AFVQEVAQLHGGRITLRNRPDG 99
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
213-432 |
3.30e-09 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 58.83 E-value: 3.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 213 SELKPLGQALNKMhhalvkdfERLS---QFADDLAHELRTPINALLGQNQVTLSqtrSIAEYQKTIAGNI-GELENISRL 288
Cdd:COG5809 252 TERKKLEELLRKS--------EKLSvvgELAAGIAHEIRNPLTSLKGFIQLLKD---TIDEEQKTYLDIMlSELDRIESI 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 289 TENILFLARADKnnvlVKLDLLSLNKEVGNLLDYLEYLSDEKEIRFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSP 365
Cdd:COG5809 321 ISEFLVLAKPQA----IKYEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDipdILGDENQLKQVFINLLKNAIEAMP 396
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 545289548 366 EKSLIHITSFLDFNGYLNIDIASPGKKINES--EKIFRRFWrgdnSRHSAGQGLGLSLVKAIAELHGGS 432
Cdd:COG5809 397 EGGNITIETKAEDDDKVVISVTDEGCGIPEErlKKLGEPFY----TTKEKGTGLGLMVSYKIIEEHGGK 461
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
274-451 |
4.41e-09 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 57.94 E-value: 4.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 274 TIAGNI--GELENISRLTENILflarADKNNVLVKLDLLSLNKEVGNLLDYLEYLSDEKEIRFKVECNQQIFADKI---L 348
Cdd:COG3290 206 TISGLLqlGEYDEALEYIDEIS----EELQELIDSLLSRIGNPVLAALLLGKAARARERGIDLTIDIDSDLPDLPLsdtD 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 349 LQRMLSNLIVNAIRYS----PEKSLIHITsFLDFNGYLNIDIASPGKKINEsEKIFRRFWRGDNSRHSAGQGLGLSLVKA 424
Cdd:COG3290 282 LVTILGNLLDNAIEAVeklpEEERRVELS-IRDDGDELVIEVEDSGPGIPE-ELLEKIFERGFSTKLGEGRGLGLALVKQ 359
|
170 180
....*....|....*....|....*...
gi 545289548 425 IAELHGGSATYHYINENN-VFRIALPQK 451
Cdd:COG3290 360 IVEKYGGTIEVESEEGEGtVFTVRLPKE 387
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-447 |
5.62e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 53.73 E-value: 5.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 349 LQRMLSNLIVNAIRYSPEKSlIHITSFLDFNG-YLNIDIAS--PGKKINESEKIFRRFWRGDNSRHSAGQ--GLGLSLVK 423
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDT-GRITVSAMPTGkMVTISVEDegPGIPQEKLESIFDRFYTERPANEAFGQhsGLGLSISR 79
|
90 100
....*....|....*....|....
gi 545289548 424 AIAELHGGSATYHYINENNVFRIA 447
Cdd:cd16953 80 QIIEAHGGISVAENHNQPGQVIGA 103
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
243-432 |
7.34e-09 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 57.77 E-value: 7.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 243 LAHELRTPINAL-----LGQNQVTLSQTRSIAEYQKTIAGNIGELENISRLTENilFLARADknnvlVKLDLLSLNKEVG 317
Cdd:COG4192 440 LAHELNQPLNAMsmylfSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQ--FSRKSD-----TPLQPVDLRQVIE 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 318 NLLDYLEYLSDEKEIRFKVECNQQIFADKILLQRMLSNLIVNAIRYSPEKSLIHItSFLDFNGYLNIDIASPGKKINESE 397
Cdd:COG4192 513 QAWELVESRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISV-DLLSNAENLRVAISDNGNGWPLVD 591
|
170 180 190
....*....|....*....|....*....|....*
gi 545289548 398 KIFRRFwrgdNSRHSAGQGLGLSLVKAIAELHGGS 432
Cdd:COG4192 592 KLFTPF----TTTKEVGLGLGLSICRSIMQQFGGD 622
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
235-299 |
1.29e-08 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 51.06 E-value: 1.29e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 545289548 235 RLSQFADDLAHELRTPINALLGQNQVtLSQTRSIAEYQKTIAGNIGELENISRLTENILFLARAD 299
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLEL-LRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIE 64
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
314-435 |
1.60e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 53.02 E-value: 1.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 314 KEVGNLLDYLEYLSDEKEIRFKVEC--NQQIFADKILLQRMLSNLIVNAIRYSPEKslIHITSFLDFNG-YLNIDIASPG 390
Cdd:cd16954 1 PLLDSLCSALNKVYQRKGVSISLDIspELRFPGERNDLMELLGNLLDNACKWCLEF--VEVTARQTDGGlHLIVDDDGPG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 545289548 391 KKINESEKIFRRFWRGDNSRhsAGQGLGLSLVKAIAELHGGSATY 435
Cdd:cd16954 79 VPESQRSKIFQRGQRLDEQR--PGQGLGLAIAKEIVEQYGGELSL 121
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
237-449 |
9.03e-08 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 54.74 E-value: 9.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 237 SQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIGELENISRLTENILFLARADKNNVLVKLDLLSLNKEV 316
Cdd:PRK09959 713 SQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLV 792
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 317 GNLLDYLEYLSDEKEIrfKVECNQQiFADKILL-------QRMLSNLIVNAIRYSPE------KSLIHITsflDFNGYLN 383
Cdd:PRK09959 793 QNTCHSFGAIAASKSI--ALSCSST-FPDHYLVkidpqafKQVLSNLLSNALKFTTEgavkitTSLGHID---DNHAVIK 866
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 545289548 384 IDIASPGKKIN--ESEKIFRRFWRGDNSRHSAGQGLGLSLVKA-IAELHGGSATYHYINENNVFRIALP 449
Cdd:PRK09959 867 MTIMDSGSGLSqeEQQQLFKRYSQTSAGRQQTGSGLGLMICKElIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
223-451 |
9.79e-08 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 53.97 E-value: 9.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 223 NKMHHALVKDFERLS---QFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIagnIGELENISRLTENILFLARaD 299
Cdd:COG5805 271 KKEAEELMARSEKLSiagQLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEEYFDIM---LSELDRIESIISEFLALAK-P 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 300 KNNVLVKLDLLSLNKEVGNLLdYLEYLSDEKEIRFKV-ECNQQIFADKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDf 378
Cdd:COG5805 347 QAVNKEKENINELIQDVVTLL-ETEAILHNIQIRLELlDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEE- 424
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 545289548 379 NGYLNIDIASPGKKINES--EKIFRRFWrgdnSRHSAGQGLGLSLVKAIAELHGGsaTYHYINENN---VFRIALPQK 451
Cdd:COG5805 425 DNSVIIRVIDEGIGIPEErlKKLGEPFF----TTKEKGTGLGLMVSYKIIENHNG--TIDIDSKVGkgtTFTITLPLS 496
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
235-299 |
1.07e-07 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 48.72 E-value: 1.07e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 545289548 235 RLSQFADDLAHELRTPINALLGQNQVTLSQTRSiAEYQKTIAGNIGELENISRLTENILFLARAD 299
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELS-EEQREYLETILREAERLLRLINDLLDLSRIE 64
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-427 |
4.25e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 48.44 E-value: 4.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 345 DKILLQRMLSNLIVNAIRYSPEKSLIHITSFlDFNGYLNIDIASPGKKINESE--KIFRRFWRGDNSRHS-AGQGLGLSL 421
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSE-TNEQGVVLSIKDFGIGIPEEDlpRVFDKGFTGENGRNFqESTGMGLYL 80
|
....*.
gi 545289548 422 VKAIAE 427
Cdd:cd16948 81 VKKLCD 86
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-434 |
4.45e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 48.09 E-value: 4.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 349 LQRMLSNLIVNAIRYSPEK--SLIHITSFLDFNGYLnIDIASPGKKINE--SEKIFRRFWRGDNSRHSAGQGLGLSLVKA 424
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWT-FYVRDNGIGIDPeyAEKVFGIFQRLHSREEYEGTGVGLAIVRK 79
|
90
....*....|
gi 545289548 425 IAELHGGSAT 434
Cdd:cd16921 80 IIERHGGRIW 89
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-429 |
6.72e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 47.58 E-value: 6.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 349 LQRMLSNLIVNAIRYSPEKSLIHITSFLDFNG-YLNIDIASPGKKINESEKIFRRFWRGD--NSRHSAGQGLGLSLVKAI 425
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGaRLSVEDTGPGIPPEHIPRLTERFYRVDieRCRNTGGTGLGLAIVKHV 80
|
....
gi 545289548 426 AELH 429
Cdd:cd16952 81 MSRH 84
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
236-451 |
1.97e-06 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 49.78 E-value: 1.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 236 LSQFADDLAHELRTPinallgqnqvtLSQTRSIAEY--QKTIAGN---------IGELENISRLTENILFLARADKnnvl 304
Cdd:PRK10364 237 LGHLAAGVAHEIRNP-----------LSSIKGLAKYfaERAPAGGeahqlaqvmAKEADRLNRVVSELLELVKPTH---- 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 305 VKLDLLSLNKEVGNLLDYLEYLSDEKEIRFKVECNQQ---IFADKILLQRMLSNLIVNAIRYSPEKSLIHITSFLDFNGy 381
Cdd:PRK10364 302 LALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTlpeIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAG- 380
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 545289548 382 LNIDIASPGKKI--NESEKIFRRFWRGDNSrhsaGQGLGLSLVKAIAELHGGSATYHYI-NENNVFRIALPQK 451
Cdd:PRK10364 381 VKISVTDSGKGIaaDQLEAIFTPYFTTKAE----GTGLGLAVVHNIVEQHGGTIQVASQeGKGATFTLWLPVN 449
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
239-431 |
3.00e-06 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 49.55 E-value: 3.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 239 FADDLAHELRTPINALLGQNQVTLsQTRSIAE---YQKTIAGNIGELENIsrlTENILFLARADKNnvlvKLDLlsLNKE 315
Cdd:PRK11091 286 FISTISHELRTPLNGIVGLSRILL-DTELTAEqrkYLKTIHVSAITLGNI---FNDIIDMDKMERR----KLQL--DNQP 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 316 VgNLLDYLEYLS-------DEKEIRFKVECN----QQIFADKILLQRMLSNLIVNAIRYSPEKSlIHITSFLDFNGYLNI 384
Cdd:PRK11091 356 I-DFTDFLADLEnlsglqaEQKGLRFDLEPLlplpHKVITDGTRLRQILWNLISNAVKFTQQGG-VTVRVRYEEGDMLTF 433
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 545289548 385 DIASPGKKINESE--KIFRRFWR---GDNSRHSAGQGLGLSLVKAIAELHGG 431
Cdd:PRK11091 434 EVEDSGIGIPEDEldKIFAMYYQvkdSHGGKPATGTGIGLAVSKRLAQAMGG 485
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
180-432 |
3.87e-06 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 49.25 E-value: 3.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 180 IRTGLREIKKL-SGVTEALNYNDTREpvevsalpseLKPLGQALNKMhhaLVKDFERLSQFA---DDLAHELRTPINALl 255
Cdd:PRK10815 219 IEALAKQVRELeEGEREQLDPNPPRE----------LTSLVRNLNRL---LKNERERYTKYRttlTDLTHSLKTPLAVL- 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 256 gqnQVTLSQTRSiaEYQKTI--AGNIgELENISRLTENI-LFLARAD---KNNVLVKlDLLSLNKEVGNLLDYLEYLSDE 329
Cdd:PRK10815 285 ---QSTLRSLRS--GKQMSVeqAEPI-MLEQISRISQQIgYYLHRASmrsEHNLLSR-ELHSVAPLLDNLTSALNKVYQR 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 330 KEIRFKVECNQQI--FADKILLQRMLSNLIVNAIRYSPEksLIHITSFLDFNG-YLNIDIASPGKKINESEKIFRRFWRG 406
Cdd:PRK10815 358 KGVNITLDISPEItfVGEKNDFMEVMGNVLDNACKYCLE--FVEISARQTDEHlHIVVEDDGPGIPESKRELIFDRGQRA 435
|
250 260
....*....|....*....|....*.
gi 545289548 407 DNSRhsAGQGLGLSLVKAIAELHGGS 432
Cdd:PRK10815 436 DTLR--PGQGLGLSVAREITEQYEGK 459
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
352-449 |
3.81e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 42.66 E-value: 3.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 352 MLSNLIVNAI----RYSPEKSLIHItSFLDFNGYLNIDIASPGKKINEsEKIFRRFWRGDNSRHSAGQGLGLSLVKAIAE 427
Cdd:cd16915 4 IVGNLIDNALdalaATGAPNKQVEV-FLRDEGDDLVIEVRDTGPGIAP-ELRDKVFERGVSTKGQGERGIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 545289548 428 LHGGSATY-HYINENNVFRIALP 449
Cdd:cd16915 82 RLGGSITVeSEPGGGTTFSIRIP 104
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
349-449 |
4.97e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 42.38 E-value: 4.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 349 LQRMLSNLIVNAIR----YSPEKSLIHITSFLDFNGYLNIDIASPGKKI--NESEKIFRRFWrgdnSRHSAGQGLGLSLV 422
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERRELTIRTSPADDRAVTISVKDTGPGIaeEVAGQLFDPFY----TTKSEGLGMGLSIC 76
|
90 100
....*....|....*....|....*...
gi 545289548 423 KAIAELHGGSATYHYINENN-VFRIALP 449
Cdd:cd16920 77 RSIIEAHGGRLSVESPAGGGaTFQFTLP 104
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
237-436 |
2.11e-04 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 43.68 E-value: 2.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 237 SQFADDLAHELRTPINALLG------QNQVTLSQTrsiaEYQKTI---AGN----IGELENISRL------TENILFLAR 297
Cdd:PRK11107 294 SEFLANMSHELRTPLNGVIGftrqtlKTPLTPTQR----DYLQTIersANNllaiINDILDFSKLeagklvLENIPFSLR 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 298 AdknnvlvkldllSLNkEVGNLldyLEYLSDEKEIRFKVECNQQI----FADKILLQRMLSNLIVNAIRYSPEKS---LI 370
Cdd:PRK11107 370 E------------TLD-EVVTL---LAHSAHEKGLELTLNIDPDVpdnvIGDPLRLQQIITNLVGNAIKFTESGNidiLV 433
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 545289548 371 HITSFLDFNGYLNIDIASPGKKINES--EKIFRRFWRGDNS---RHsAGQGLGLSLVKAIAELHGGSATYH 436
Cdd:PRK11107 434 ELRALSNTKVQLEVQIRDTGIGISERqqSQLFQAFRQADASisrRH-GGTGLGLVITQKLVNEMGGDISFH 503
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
220-434 |
5.68e-04 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 42.32 E-value: 5.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 220 QALNKMHHALVKDFERLSQFADDLAHELRTPINALLGQnqVTLSQTRSIAEYQKTIAgnigelENISRLTENILFLArad 299
Cdd:PRK15347 382 QALAEAKQRAEQANKRKSEHLTTISHEIRTPLNGVLGA--LELLQNTPLTAEQMDLA------DTARQCTLSLLAII--- 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 300 kNNVL----VKLDLLSLNKEVGNLLDYLEYL-------SDEKEIRFKVECNQQI----FADKILLQRMLSNLIVNAIRYS 364
Cdd:PRK15347 451 -NNLLdfsrIESGQMTLSLEETALLPLLDQAmltiqgpAQSKSLTLRTFVGAHVplylHLDSLRLRQILVNLLGNAVKFT 529
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 545289548 365 PEKS-LIHITSFldfNGYLNIDIASPGKKINES--EKIFRRFWRGDNsrHSAGQGLGLSLVKAIAELHGGSAT 434
Cdd:PRK15347 530 ETGGiRLRVKRH---EQQLCFTVEDTGCGIDIQqqQQIFTPFYQADT--HSQGTGLGLTIASSLAKMMGGELT 597
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-449 |
1.13e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 38.56 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 348 LLQRMLSNLIVNAIRYSPEKSLIHITSFLDFNGYLnIDIASPGKKINES--EKIFRRFWrgDNSRHSAGQGLGLSLVKAI 425
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVL-IEVEDTGSGIDPEilGRIFDPFF--TTKPVGEGTGLGLSLSYRI 79
|
90 100
....*....|....*....|....*
gi 545289548 426 AELHGGSATYHYI-NENNVFRIALP 449
Cdd:cd16943 80 IQKHGGTIRVASVpGGGTRFTIILP 104
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
45-449 |
2.77e-03 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 40.00 E-value: 2.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 45 LINRTAQIKQLLIDGVNPDTLPVYFNRMMDVSQDILIIHGDGINKIVNRTNVSDDMLNNIPATETISAPGIYRSIINDTE 124
Cdd:COG2972 47 LILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 125 IDALQININEISPVLTVTVAKLASArhnmLEQYKINSIIICIVAIILCSVLSPLLIRTGLREIKKLSGVTEALNYNDTRE 204
Cdd:COG2972 127 IILLLLSLLGWTLVSLIPKSELFRG----LFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVR 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 205 PVEVSalPSELKPLGQALNKMH---HALVKDFERLSQfaddLAHELRtpINALlgQNQV-------TLSQTRSIAEyqkt 274
Cdd:COG2972 203 LEVSG--NDEIGILARSFNEMVeriKELIEEVYELEL----EKKEAE--LKAL--QAQInphflfnTLNSIRWLAE---- 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 275 iagnIGELENISRLTENILFLARA--DKNNvlvklDLLSLNKEVGNLLDYLE-----YlsdEKEIRFKVECNQQIfADKI 347
Cdd:COG2972 269 ----LEDPEEAEEMLEALSKLLRYslSKGD-----ELVTLEEELELIKSYLEiqklrF---GDRLEVEIEIDEEL-LDLL 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 348 LLQRMLSNLIVNAIRY----SPEKSLIHITSFLDfNGYLNIDIASPGKKINES--EKIFRRFwrgdnSRHSAGQGLGLSL 421
Cdd:COG2972 336 IPKLILQPLVENAIEHgiepKEGGGTIRISIRKE-GDRLVITVEDNGVGMPEEklEKLLEEL-----SSKGEGRGIGLRN 409
|
410 420 430
....*....|....*....|....*....|..
gi 545289548 422 VKAIAELH-GGSATYHYINENNVF---RIALP 449
Cdd:COG2972 410 VRERLKLYyGEEYGLEIESEPGEGttvTIRIP 441
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
206-431 |
2.86e-03 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 40.05 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 206 VEVSALPSELKPLGQALnkmHHAlvKDFERLSQFADDLAHELRTPINALLGQNQVTLSQTRSIAEYQKTIAGNIGELENI 285
Cdd:PRK13837 425 IERRRLETERDALERRL---EHA--RRLEAVGTLASGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARA 499
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 286 SRLTENILFLARAdKNNVLVKLDLLSLNKEVGNLLDyleyLSDEKEIRFKVECNQQ---IFADKILLQRMLSNLIVNAIR 362
Cdd:PRK13837 500 RLIIDQILAFGRK-GERNTKPFDLSELVTEIAPLLR----VSLPPGVELDFDQDQEpavVEGNPAELQQVLMNLCSNAAQ 574
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545289548 363 YSPEKSLIHIT--------------SFLDFNGYLNIDIASPGKKINES--EKIFRRFWrgdnSRHSAGQGLGLSLVKAIA 426
Cdd:PRK13837 575 AMDGAGRVDISlsraklrapkvlshGVLPPGRYVLLRVSDTGAGIDEAvlPHIFEPFF----TTRAGGTGLGLATVHGIV 650
|
....*
gi 545289548 427 ELHGG 431
Cdd:PRK13837 651 SAHAG 655
|
|
| |
