|
Name |
Accession |
Description |
Interval |
E-value |
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
16-375 |
1.50e-120 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 353.38 E-value: 1.50e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 16 DLFDALAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLPEAAGWfrRRAAAPGAVEAASFMLPAVEFLRGLL 95
Cdd:COG3852 11 AILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPL--RELLERALAEGQPVTEREVTLRRKDG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 96 PSVRVRASFSSLSpkpsNAPSGTTALLEVVDLDDALRAERDAIAEAGRAANSELLRNLAHEIKNPLGGIRGAAQLLESEL 175
Cdd:COG3852 89 EERPVDVSVSPLR----DAEGEGGVLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLEREL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 176 VRDEDRECTNVILEEAARLQELVDRLLMPYRT-PAAAGPVNIHEVLEHVRSLIGLEFAQGLTIERDYDISAPAVFGDRGR 254
Cdd:COG3852 165 PDDELREYTQLIIEEADRLNNLVDRLLSFSRPrPPEREPVNLHEVLERVLELLRAEAPKNIRIVRDYDPSLPEVLGDPDQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 255 FTQVFLNLARNAAEAMTEGrahgtAVIIFKTRIARDVMLAGTRTRTALRIDVVDNGPGVPEHLKERIFFPLVTGRAEGSG 334
Cdd:COG3852 245 LIQVLLNLVRNAAEAMPEG-----GTITIRTRVERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEKGTG 319
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 547261035 335 LGLALVKTFVEEAGGSITLESRPG-RTDFTVLLPLEGREARE 375
Cdd:COG3852 320 LGLAIVQKIVEQHGGTIEVESEPGkGTTFRIYLPLEQAEEEP 361
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
17-368 |
6.96e-85 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 261.94 E-value: 6.96e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 17 LFDALAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDvaefLPEAAGWFrrraaapgaveaaSFMLpavEFLRGLLP 96
Cdd:PRK11073 12 ILNSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTP----LPELLSYF-------------SLNI---ELMRESLQ 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 97 S------------VRVRASFSSLSPKPSnapSGTTALLEVVDLDDALRAERDAIAEAGRAANSELLRNLAHEIKNPLGGI 164
Cdd:PRK11073 72 AgqgftdnevtlvIDGRSHILSLTAQRL---PEGMILLEMAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 165 RGAAQLLESELVRDEDRECTNVILEEAARLQELVDRLLMPYRtPAAAGPVNIHEVLEHVRSLIGLEFAQGLTIERDYDIS 244
Cdd:PRK11073 149 RGAAQLLSKALPDPALTEYTKVIIEQADRLRNLVDRLLGPQR-PGTHVTESIHKVAERVVQLVSLELPDNVRLIRDYDPS 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 245 APAVFGDRGRFTQVFLNLARNAAEAMTEGraHGTavIIFKTRIARDVMLAGTRTRTALRIDVVDNGPGVPEHLKERIFFP 324
Cdd:PRK11073 228 LPELAHDPDQIEQVLLNIVRNALQALGPE--GGT--ITLRTRTAFQLTLHGERYRLAARIDIEDNGPGIPPHLQDTLFYP 303
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 547261035 325 LVTGRAEGSGLGLALVKTFVEEAGGSITLESRPGRTDFTVLLPL 368
Cdd:PRK11073 304 MVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGHTEFSVYLPI 347
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
17-373 |
1.01e-61 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 204.43 E-value: 1.01e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 17 LFDALAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLPEAAgwfrrrAAAPGAVEAASFMLPAVEFLRGLLP 96
Cdd:COG5000 95 ILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELD------LAELLREALERGWQEEIELTRDGRR 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 97 SVRVRASfsslspkpsnAPSGTTALLEVVDLDDALRAERdaiaeagRAANSELLRNLAHEIKNPLGGIRGAAQLLESEL- 175
Cdd:COG5000 169 TLLVRAS----------PLRDDGYVIVFDDITELLRAER-------LAAWGELARRIAHEIKNPLTPIQLSAERLRRKLa 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 176 -----VRDEDRECTNVILEEAARLQELVDRLLMPYRTPAAA-GPVNIHEVLEHVRSLIGLEFAQ-GLTIERDYDISAPAV 248
Cdd:COG5000 232 dkleeDREDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQlEPVDLNELLREVLALYEPALKEkDIRLELDLDPDLPEV 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 249 FGDRGRFTQVFLNLARNAAEAMTEGrahgtAVIIFKTRIARDvmlagtrtrtALRIDVVDNGPGVPEHLKERIFFPLVTG 328
Cdd:COG5000 312 LADRDQLEQVLINLLKNAIEAIEEG-----GEIEVSTRREDG----------RVRIEVSDNGPGIPEEVLERIFEPFFTT 376
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 547261035 329 RAEGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPLEGREA 373
Cdd:COG5000 377 KPKGTGLGLAIVKKIVEEHGGTIELESRPGGgTTFTIRLPLAEEAE 422
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
23-368 |
1.37e-50 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 173.45 E-value: 1.37e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 23 EAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLPEAAGWFRRRAAAPGAVEAASFMLPAVEFLRGLLPSVRVRA 102
Cdd:COG4191 1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 103 SFSSLSPKPSNAPSGTTALLEVVDLDDALRAERDAIAEAGRA------ANSELLRN------------LAHEIKNPLGGI 164
Cdd:COG4191 81 LLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAeeelreLQEQLVQSeklaalgelaagIAHEINNPLAAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 165 RGAAQLLESELVRDED----RECTNVILEEAARLQELVDRLLMPYR-TPAAAGPVNIHEVLEHVRSLIGLEF-AQGLTIE 238
Cdd:COG4191 161 LGNAELLRRRLEDEPDpeelREALERILEGAERAAEIVRSLRAFSRrDEEEREPVDLNELIDEALELLRPRLkARGIEVE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 239 RDYDISAPAVFGDRGRFTQVFLNLARNAAEAMtEGRAHGTavIIFKTRIARDvmlagtrtrtALRIDVVDNGPGVPEHLK 318
Cdd:COG4191 241 LDLPPDLPPVLGDPGQLEQVLLNLLINAIDAM-EEGEGGR--ITISTRREGD----------YVVISVRDNGPGIPPEVL 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 547261035 319 ERIFFPLVT--GRAEGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPL 368
Cdd:COG4191 308 ERIFEPFFTtkPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGgTTFTITLPL 360
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
37-369 |
2.67e-49 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 169.32 E-value: 2.67e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 37 ANAAAETLIGRTRRALSGVDVAEFLPEAAGWFRRRAAAPGAVEAASFMLPAVEFLRGLLPSVRVRASFSSLSPKPSNAPS 116
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 117 GTTALLEVVDLDDALRAERDAIAEAGRAANSELLRNLAHEIKNPLGGIRGAAQLLESElVRDEDRECTNVILEEAARLQE 196
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE-LDEEQREYLETILRSADRLLR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 197 LVDRLLMPYRTPAAAG-----PVNIHEVLEHVRSLIGLEFAQ-GLTIERDYDISAPAVFGDRGRFTQVFLNLARNAAEAM 270
Cdd:COG0642 160 LINDLLDLSRLEAGKLelepePVDLAELLEEVVELFRPLAEEkGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 271 TEGRAhgtaviifktriardVMLAGTRTRTALRIDVVDNGPGVPEHLKERIFFPLVTG----RAEGSGLGLALVKTFVEE 346
Cdd:COG0642 240 PEGGT---------------VTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTdpsrRGGGTGLGLAIVKRIVEL 304
|
330 340
....*....|....*....|....
gi 547261035 347 AGGSITLESRPGR-TDFTVLLPLE 369
Cdd:COG0642 305 HGGTIEVESEPGKgTTFTVTLPLA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
130-369 |
2.84e-47 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 161.23 E-value: 2.84e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 130 ALRAERDAIAEAgRAANSELLRNLAHEIKNPLGGIRGAAQLLES--ELVRDEDRECTNVILEEAARLQELVDRLLMPYRT 207
Cdd:COG2205 1 ELEEALEELEEL-ERLKSEFLANVSHELRTPLTSILGAAELLLDeeDLSPEERRELLEIIRESAERLLRLIEDLLDLSRL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 208 PAAA-----GPVNIHEVLEHVRSLIGLEFAQ-GLTIERDYDISAPAVFGDRGRFTQVFLNLARNAAEAMTEGRahgtavi 281
Cdd:COG2205 80 ESGKlslelEPVDLAELLEEAVEELRPLAEEkGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGG------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 282 ifktriarDVMLAGTRTRTALRIDVVDNGPGVPEHLKERIFFPLVTG----RAEGSGLGLALVKTFVEEAGGSITLESRP 357
Cdd:COG2205 153 --------TITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGdnsrGEGGTGLGLAIVKRIVEAHGGTIWVESEP 224
|
250
....*....|...
gi 547261035 358 GR-TDFTVLLPLE 369
Cdd:COG2205 225 GGgTTFTVTLPLA 237
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
17-368 |
1.98e-45 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 159.95 E-value: 1.98e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 17 LFDALAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAE---FLPEAAGWFRRRAAAPGAveaaSFMLPAVEFLRG 93
Cdd:COG5807 32 LFDSILEFVFFIDSKGEILECNDFAEDLYGLSQNEYIGKTFVEekcILKDEQLYNKEAFDRIEI----SYLTKNGEFDEI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 94 LLPSVRVRASFSSLSPKPSNApsgtTALLEVVDLDdaLRAERDAIAeagraanSELLRNLAHEIKNPLGGIRGAAQLLES 173
Cdd:COG5807 108 IYPIYYKDGVILGLITVYRDI----TKRKEAEDKL--LRSEKLSVA-------GELAAGIAHEIRNPLTSIKGFLQLLQE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 174 ELVRDEDRECTNVILEEAARLQELVDRLLMPYRTPAAA-GPVNIHEVLEHVRSLIGLEFA-QGLTIERDYDISAPAVFGD 251
Cdd:COG5807 175 SREDSEREEYFNIIISEIDRINTIITELLVLSKPKKFNfKKLNLNDVLEDVIALLSTEAIlKNISIKYDLADDEPVINGD 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 252 RGRFTQVFLNLARNAAEAMTEGrahgtAVIIFKTriardvmlagTRTRTALRIDVVDNGPGVPEHLKERIFFPLVTGRAE 331
Cdd:COG5807 255 KNQLKQVFINLIKNAIEAMETG-----GNITIKT----------YVEGDFVVISVKDEGIGIPEEVLEKIGEPFFTTKEE 319
|
330 340 350
....*....|....*....|....*....|....*...
gi 547261035 332 GSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPL 368
Cdd:COG5807 320 GTGLGLSICKKIIEEHNGTIEVESKPGKgTTFTIYLPL 357
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
256-367 |
3.98e-42 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 143.31 E-value: 3.98e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 256 TQVFLNLARNAAEAMteGRAHGTavIIFKTRIARDVMLAGTRTRTALRIDVVDNGPGVPEHLKERIFFPLVTGRAEGSGL 335
Cdd:cd16918 2 IQVFLNLVRNAAQAL--AGSGGE--IILRTRTQRQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGL 77
|
90 100 110
....*....|....*....|....*....|..
gi 547261035 336 GLALVKTFVEEAGGSITLESRPGRTDFTVLLP 367
Cdd:cd16918 78 GLAIAQNIVSQHGGVIECDSQPGHTVFSVSLP 109
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
22-369 |
5.77e-41 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 152.43 E-value: 5.77e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 22 AEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLPEA---AGWFRRRAAAPGAVEAASFMLPAVEflRGLLPSV 98
Cdd:PRK11360 272 ADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELFPPNtpfASPLLDTLEHGTEHVDLEISFPGRD--RTIELSV 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 99 RvrasfSSLSPKPSNAPSGttALLEVVDLDDALRAERDaIAEAGR-AANSELLRNLAHEIKNPLGGIRGAAQLLESELVR 177
Cdd:PRK11360 350 S-----TSLLHNTHGEMIG--ALVIFSDLTERKRLQRR-VARQERlAALGELVAGVAHEIRNPLTAIRGYVQIWRQQTSD 421
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 178 DEDRECTNVILEEAARLQELVDRLLMPYR-TPAAAGPVNIHEVLEHVRSLIG-LEFAQGLTIERDYDISAPAVFGDRGRF 255
Cdd:PRK11360 422 PPSQEYLSVVLREVDRLNKVIDQLLEFSRpRESQWQPVSLNALVEEVLQLFQtAGVQARVDFETELDNELPPIWADPELL 501
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 256 TQVFLNLARNAAEAMTEGrahGTAVIIFKTRIARDVMlagtrtrtalrIDVVDNGPGVPEHLKERIFFPLVTGRAEGSGL 335
Cdd:PRK11360 502 KQVLLNILINAVQAISAR---GKIRIRTWQYSDGQVA-----------VSIEDNGCGIDPELLKKIFDPFFTTKAKGTGL 567
|
330 340 350
....*....|....*....|....*....|....*
gi 547261035 336 GLALVKTFVEEAGGSITLESRPGR-TDFTVLLPLE 369
Cdd:PRK11360 568 GLALSQRIINAHGGDIEVESEPGVgTTFTLYLPIN 602
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
14-375 |
8.19e-40 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 147.43 E-value: 8.19e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 14 SFDLFDALAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLPEAAgwfRRRAAAPGAVEAASFMLPAVEFLRG 93
Cdd:COG5809 143 FRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDD---QENVAAFISQLLKDGGIAQGEVRFW 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 94 LLPSVRVRASFSSLSPKPSNAPSGTTALL----EVVDLDDALR-AERDAIAeagraanSELLRNLAHEIKNPLGGIRGAA 168
Cdd:COG5809 220 TKDGRWRLLEASGAPIKKNGEVDGIVIIFrditERKKLEELLRkSEKLSVV-------GELAAGIAHEIRNPLTSLKGFI 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 169 QLLEsELVRDEDRECTNVILEEAARLQELVDRLLMPYRTPAAAG-PVNIHEVLEHVRSLIGLEfA--QGLTIERDYDISA 245
Cdd:COG5809 293 QLLK-DTIDEEQKTYLDIMLSELDRIESIISEFLVLAKPQAIKYePKDLNTLIEEVIPLLQPQ-AllKNVQIELELEDDI 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 246 PAVFGDRGRFTQVFLNLARNAAEAMTEGrahGTAVIifKTRIARDvmlagtrtrTALRIDVVDNGPGVPEHLKERIFFPL 325
Cdd:COG5809 371 PDILGDENQLKQVFINLLKNAIEAMPEG---GNITI--ETKAEDD---------DKVVISVTDEGCGIPEERLKKLGEPF 436
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 547261035 326 VTGRAEGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPLEGREARE 375
Cdd:COG5809 437 YTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKgTTFSITLPIKLSEQVS 487
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
15-369 |
1.05e-38 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 142.77 E-value: 1.05e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 15 FDLFDALAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLPEAAGWFRRRAAAPGAVEAASFMLPAVEFLRGL 94
Cdd:COG5002 40 LLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 95 LPSVRVRASFSSLSPKPSNAPSGTTALLEVVDLDDALRAERdaiAEAGRaanSELLRNLAHEIKNPLGGIRGAAQLLESE 174
Cdd:COG5002 120 LLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELER---LEQMR---REFVANVSHELRTPLTSIRGYLELLLDG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 175 LVRDED--RECTNVILEEAARLQELVDRLLMPYR-----TPAAAGPVNIHEVLEHVRSLIGLEFAQ-GLTIERDYDISAP 246
Cdd:COG5002 194 AADDPEerREYLEIILEEAERLSRLVNDLLDLSRlesgeLKLEKEPVDLAELLEEVVEELRPLAEEkGIELELDLPEDPL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 247 AVFGDRGRFTQVFLNLARNAAEAMTEGRAhgtaviifktriardVMLAGTRTRTALRIDVVDNGPGVPEHLKERIFFPLV 326
Cdd:COG5002 274 LVLGDPDRLEQVLTNLLDNAIKYTPEGGT---------------ITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFY 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 547261035 327 TGRA------EGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPLE 369
Cdd:COG5002 339 RVDKsrsretGGTGLGLAIVKHIVEAHGGRIWVESEPGKgTTFTITLPLA 388
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
147-368 |
2.15e-36 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 137.57 E-value: 2.15e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 147 SELLRNLAHEIKNPLGGIRGAAQLLESELVRDEDRECTNVILEEAARLQELV-DRLLMPYRTPAAAGPVNIHEVLEHVRS 225
Cdd:COG5808 242 GTFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQKYFDIIQEEIQRINQIVsEFLVLGKPTAKKLELDDLNELIEEILS 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 226 LIGLEFA-QGLTIER-DYDISAPaVFGDRGRFTQVFLNLARNAAEAMTEGrahgtaviifktriaRDVMLAGTRTRTALR 303
Cdd:COG5808 322 IIDSEANlKNIRVEKqSLDEPLH-IKCDKDRIKQVLLNLIKNAIEAMKEG---------------GKLTISIENDDEKAV 385
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 547261035 304 IDVVDNGPGVPEHLKERIFFPLVTGRAEGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPL 368
Cdd:COG5808 386 IEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKgTTFTIRLPL 451
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
16-368 |
1.86e-34 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 132.93 E-value: 1.86e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 16 DLFDALAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLPEA-----AGWFRRRAAAPGAVEAASFMLPAVEF 90
Cdd:COG5805 161 TLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHPCdkeefKERIESITEVWQEFIIEREIITKDGR 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 91 LRgllpSVRVRasfssLSPKPSNAPSGTTALLEVVDLDDALRAER-----DAIAEAGRAANSellrnLAHEIKNPLGGIR 165
Cdd:COG5805 241 IR----YFEAV-----IVPLIDTDGSVKGILVILRDITEKKEAEElmarsEKLSIAGQLAAG-----IAHEIRNPLTSIK 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 166 GAAQLLESELvrDEDRECTNVILEEAARLQELVDRLLMPYRtPAAAG--PVNIHEVLEHVRSLIGLEfA--QGLTIERDY 241
Cdd:COG5805 307 GFLQLLQPGI--EDKEEYFDIMLSELDRIESIISEFLALAK-PQAVNkeKENINELIQDVVTLLETE-AilHNIQIRLEL 382
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 242 DISAPAVFGDRGRFTQVFLNLARNAAEAMTEGrahGTAVIifktriardvmlagtRTRTA---LRIDVVDNGPGVPEHLK 318
Cdd:COG5805 383 LDEDPFIYCDENQIKQVFINLIKNAIEAMPNG---GTITI---------------HTEEEdnsVIIRVIDEGIGIPEERL 444
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 547261035 319 ERIFFPLVTGRAEGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPL 368
Cdd:COG5805 445 KKLGEPFFTTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKgTTFTITLPL 495
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
130-371 |
1.10e-27 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 113.34 E-value: 1.10e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 130 ALRAERDAIAEAGR----AANSELLRNLAHEIKNPLGGIRGAAQLL-ESELVRDEDRECTNVILEEAARLQELVDRLLMP 204
Cdd:PRK10364 217 YLRSRQLLQDEMKRkeklVALGHLAAGVAHEIRNPLSSIKGLAKYFaERAPAGGEAHQLAQVMAKEADRLNRVVSELLEL 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 205 YR-TPAAAGPVNIHEVLEHVRSLIGLEfAQGLTIERDYDISA--PAVFGDRGRFTQVFLNLARNAAEAMTEgraHGTavi 281
Cdd:PRK10364 297 VKpTHLALQAVDLNDLINHSLQLVSQD-ANSREIQLRFTANDtlPEIQADPDRLTQVLLNLYLNAIQAIGQ---HGV--- 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 282 ifktriardVMLAGTRTRTALRIDVVDNGPGVPEHLKERIFFPLVTGRAEGSGLGLALVKTFVEEAGGSITLESRPGR-T 360
Cdd:PRK10364 370 ---------ISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKgA 440
|
250
....*....|.
gi 547261035 361 DFTVLLPLEGR 371
Cdd:PRK10364 441 TFTLWLPVNIT 451
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
2-369 |
4.80e-27 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 112.19 E-value: 4.80e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 2 TEKESLTDAVGTSFDLFDALAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLPEAAGWFRRRAAAPGAVEAA 81
Cdd:COG4251 135 LLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLE 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 82 SFMLPAVEFLRGLLPSVRVRASFSSLSPKPSNAPSGTTALLEVVDLDDALRAERDAIAEAGRAANSELlRNLA----HEI 157
Cdd:COG4251 215 AELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEEL-EQFAyvasHDL 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 158 KNPLGGIRGAAQLLESEL---VRDEDRECTNVILEEAARLQELVDRLLMpY----RTPAAAGPVNIHEVLEHVRSLIGLE 230
Cdd:COG4251 294 REPLRKISGFSQLLEEDYgdkLDEEGREYLERIRDAAERMQALIDDLLA-YsrvgRQELEFEPVDLNELLEEVLEDLEPR 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 231 FAQ-GLTIERDydiSAPAVFGDRGRFTQVFLNLARNAAEAMTEGRahgTAVIIFKTRiardvmlagtRTRTALRIDVVDN 309
Cdd:COG4251 373 IEErGAEIEVG---PLPTVRGDPTLLRQVFQNLISNAIKYSRPGE---PPRIEIGAE----------REGGEWVFSVRDN 436
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 547261035 310 GPGVPEHLKERIFFPLVT----GRAEGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPLE 369
Cdd:COG4251 437 GIGIDPEYAEKIFEIFQRlhsrDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEgATFYFTLPKA 501
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
123-358 |
2.65e-25 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 106.85 E-value: 2.65e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 123 EVVDLDDALRAERDAIAeaGRAANSELLRNLAHEIKNPLGGIRGAAQLLESELVRDEDRECTNVILEEAARLQELVDRLL 202
Cdd:PRK11100 235 ELRELAQALESMRVKLE--GKAYVEQYVQTLTHELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLL 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 203 MPYR-----TPAAAGPVNIHEVLEHVRSLIGLEFAQ-GLTIErdYDISAPAVFGDRGRFTQVFLNLARNAAEAMTEGrah 276
Cdd:PRK11100 313 ELARleqrqELEVLEPVALAALLEELVEAREAQAAAkGITLR--LRPDDARVLGDPFLLRQALGNLLDNAIDFSPEG--- 387
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 277 GTaviifktriardVMLAGTRTRTALRIDVVDNGPGVPEHLKERI---FFPLV---TGRaEGSGLGLALVKTFVEEAGGS 350
Cdd:PRK11100 388 GT------------ITLSAEVDGEQVALSVEDQGPGIPDYALPRIferFYSLPrpaNGR-KSTGLGLAFVREVARLHGGE 454
|
....*...
gi 547261035 351 ITLESRPG 358
Cdd:PRK11100 455 VTLRNRPE 462
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
128-368 |
2.04e-24 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 103.41 E-value: 2.04e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 128 DDALRAERDAIAeagraanSELLRNLAHEIKNPLGGIRGAAQLLESELVRDEDR-ECTNVILEEAARLQELV-DRLLMPY 205
Cdd:COG5806 190 KELQRAEKLEVV-------SELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRkQYIRIALEELDRAEAIItDYLTFAK 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 206 RTPAAAGPVNIHEVLEHVRSLIgLEFAQGLTIERDYDISAPA-VFGDRGRFTQVFLNLARNAAEAMTEGrahGTAVIifk 284
Cdd:COG5806 263 PQPEKLEKIDVSEELEHVIDVL-SPYANMNNVEIQTELEPGLyIEGDRQKLQQCLINIIKNGIEAMPNG---GTLTI--- 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 285 triarDVMLAGtrtRTALrIDVVDNGPGV-PEHLkERIFFPLVTGRAEGSGLGLALVKTFVEEAGGSITLESRPGR-TDF 362
Cdd:COG5806 336 -----DVSIDK---NKVI-ISIKDTGVGMtKEQL-ERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKgTTF 405
|
....*.
gi 547261035 363 TVLLPL 368
Cdd:COG5806 406 TITLPL 411
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
153-373 |
4.46e-24 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 104.37 E-value: 4.46e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 153 LAHEIKNPLGGIRGAAQLLESELVRDED-RECTNVILEEAARLQELVDRLL-MPYRTPAAAGPVNIHEVLEHVRSLIGLE 230
Cdd:PRK13837 457 IAHNFNNILGAILGYAEMALNKLARHSRaARYIDEIISAGARARLIIDQILaFGRKGERNTKPFDLSELVTEIAPLLRVS 536
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 231 FAQGLTIERDYDISAPAVFGDRGRFTQVFLNLARNAAEAMTEGrahGTAVIIFKTRIAR--DVMLAGT-RTRTALRIDVV 307
Cdd:PRK13837 537 LPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGA---GRVDISLSRAKLRapKVLSHGVlPPGRYVLLRVS 613
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 547261035 308 DNGPGVPEHLKERIFFPLVTGRAEGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPLEGREA 373
Cdd:PRK13837 614 DTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRgTRFDVYLPPSSKVP 680
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
250-369 |
4.18e-23 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 92.71 E-value: 4.18e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 250 GDRGRFTQVFLNLARNAAEAMTEGRahgtaviifktriarDVMLAGTRTRTALRIDVVDNGPGVPEHLKERIFFPLVTGR 329
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGG---------------RITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD 65
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 547261035 330 A-----EGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPLE 369
Cdd:smart00387 66 KrsrkiGGTGLGLSIVKKLVELHGGEISVESEPGGgTTFTITLPLE 111
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
17-371 |
5.41e-23 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 99.15 E-value: 5.41e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 17 LFDALAEAVFLLDDEGRITSANAAAETLIGRtrrALSGVDVAEFLPEAAGWFRRRAaapgaveaasfmlpaVEFLRGLLP 96
Cdd:COG3290 89 VLESIREGVIAVDRDGRITLINDAARRLLGL---DAIGRPIDEVLAEVLETGERDE---------------EILLNGRVL 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 97 SVRVRASFSSlspkpsNAPSGTTALLEVVDLDDALRAERDAIAEAgraanSELLRNLAHEIKNPLGGIRGAAQLLESELV 176
Cdd:COG3290 151 VVNRVPIRDD------GRVVGAVATFRDRTELERLEEELEGVKEL-----AEALRAQRHDFRNHLHTISGLLQLGEYDEA 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 177 RDedrectnVILEEAARLQELVDRLLmpyrtpaaagpVNIHEVLehVRSLIGLEFAQG------LTIERDYDISAPAVfg 250
Cdd:COG3290 220 LE-------YIDEISEELQELIDSLL-----------SRIGNPV--LAALLLGKAARArergidLTIDIDSDLPDLPL-- 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 251 DRGRFTQVFLNLARNAAEAMTEGRAHgtaviifktriARDVMLAGTRTRTALRIDVVDNGPGVPEHLKERIFFPLV-TGR 329
Cdd:COG3290 278 SDTDLVTILGNLLDNAIEAVEKLPEE-----------ERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFsTKL 346
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 547261035 330 AEGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPLEGR 371
Cdd:COG3290 347 GEGRGLGLALVKQIVEKYGGTIEVESEEGEgTVFTVRLPKEGE 389
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
257-367 |
7.50e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 83.60 E-value: 7.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 257 QVFLNLARNAAEAMTEGRAHGTAVIIFKTRIARDvmlagtrtrtALRIDVVDNGPGVPEHLKERIFFPLVTGRAEGSGLG 336
Cdd:cd16920 3 QVLINLVRNGIEAMSEGGCERRELTIRTSPADDR----------AVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMG 72
|
90 100 110
....*....|....*....|....*....|..
gi 547261035 337 LALVKTFVEEAGGSITLESRPGR-TDFTVLLP 367
Cdd:cd16920 73 LSICRSIIEAHGGRLSVESPAGGgATFQFTLP 104
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
250-369 |
1.21e-19 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 83.19 E-value: 1.21e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 250 GDRGRFTQVFLNLARNAAEAMTEGrahGTAVIifktRIARDVMLagtrtrtalRIDVVDNGPGVPEHLKERIFFPLVTG- 328
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKA---GEITV----TLSEGGEL---------TLTVEDNGIGIPPEDLPRIFEPFSTAd 64
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 547261035 329 --RAEGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPLE 369
Cdd:pfam02518 65 krGGGGTGLGLSIVRKLVELLGGTITVESEPGGgTTVTLTLPLA 108
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
105-358 |
1.15e-18 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 86.54 E-value: 1.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 105 SSLSPKPSNAPSGTTALLEVVDLDDALRAERDAIAEAGRAANSeLLRNLAHEIKNPLGGIRGAAQLLESELVRDEDRECT 184
Cdd:PRK09303 111 ENLQPSEIDSGRYSQELLQLSDELFVLRQENETLLEQLKFKDR-VLAMLAHDLRTPLTAASLALETLELGQIDEDTELKP 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 185 NVI--LEEAARLQ-ELVDRL----LMPYRTPAAAGPVNIH---------EVLEHVRSLIgleFAQGLTIERDYDISAPAV 248
Cdd:PRK09303 190 ALIeqLQDQARRQlEEIERLitdlLEVGRTRWEALRFNPQkldlgslcqEVILELEKRW---LAKSLEIQTDIPSDLPSV 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 249 FGDRGRFTQVFLNLARNAAEAMTEGrahGTAVIIfktriardvMLAgtRTRTALRIDVVDNGPGVPEHLKERIFFPLV-- 326
Cdd:PRK09303 267 YADQERIRQVLLNLLDNAIKYTPEG---GTITLS---------MLH--RTTQKVQVSICDTGPGIPEEEQERIFEDRVrl 332
|
250 260 270
....*....|....*....|....*....|....
gi 547261035 327 --TGRAEGSGLGLALVKTFVEEAGGSITLESRPG 358
Cdd:PRK09303 333 prDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPG 366
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
257-368 |
1.08e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 77.92 E-value: 1.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 257 QVFLNLARNAAEAMTEGrahgtAVIIfktRIARDvmlAGTRTRTALRIDVVDNGPGVPEHLKERIFFPLV------TGRA 330
Cdd:cd16922 3 QILLNLLGNAIKFTEEG-----EVTL---RVSLE---EEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSqadsstTRKY 71
|
90 100 110
....*....|....*....|....*....|....*....
gi 547261035 331 EGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPL 368
Cdd:cd16922 72 GGTGLGLAISKKLVELMGGDISVESEPGQgSTFTFTLPL 110
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
251-359 |
6.04e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 76.04 E-value: 6.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 251 DRGRFTQVFLNLARNAAEAMtEGRAHGTAVIIFKTRIARDVMLAgtrtrtalrIDVVDNGPGVPEHLKERIFFPLVTGRA 330
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAI-EGRPSDVGEVRIRVEADQDGRIV---------LIVCDNGKGFPREMRHRATEPYVTTRP 70
|
90 100
....*....|....*....|....*....
gi 547261035 331 EGSGLGLALVKTFVEEAGGSITLESRPGR 359
Cdd:cd16944 71 KGTGLGLAIVKKIMEEHGGRISLSNREAG 99
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
257-368 |
8.14e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 75.54 E-value: 8.14e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 257 QVFLNLARNAAEAMtEGRahGTAVIifktRIARDVmlagtrtrTALRIDVVDNGPGVPEHLKERIFFPLVTGR--AEGSG 334
Cdd:cd16943 6 QVLLNLLVNAAQAM-EGR--GRITI----RTWAHV--------DQVLIEVEDTGSGIDPEILGRIFDPFFTTKpvGEGTG 70
|
90 100 110
....*....|....*....|....*....|....*
gi 547261035 335 LGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPL 368
Cdd:cd16943 71 LGLSLSYRIIQKHGGTIRVASVPGGgTRFTIILPI 105
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
133-369 |
9.11e-15 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 76.22 E-value: 9.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 133 AERD-AIAEAGRAA------NSELLRNLAHEIKNPLGGIRGAAQLLE-SEL------VRDEDRECTNVIL---------- 188
Cdd:PRK15347 378 AERTqALAEAKQRAeqankrKSEHLTTISHEIRTPLNGVLGALELLQnTPLtaeqmdLADTARQCTLSLLaiinnlldfs 457
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 189 -----------EEAARLQeLVDRLLMPYRTPAAAGPVNIhevlehvRSLIGLEFAQGLTIerdydisapavfgDRGRFTQ 257
Cdd:PRK15347 458 riesgqmtlslEETALLP-LLDQAMLTIQGPAQSKSLTL-------RTFVGAHVPLYLHL-------------DSLRLRQ 516
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 258 VFLNLARNAAEAMTEGRahgtaviifktriardVMLAGTRTRTALRIDVVDNGPGVPEHLKERIFFPL--VTGRAEGSGL 335
Cdd:PRK15347 517 ILVNLLGNAVKFTETGG----------------IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFyqADTHSQGTGL 580
|
250 260 270
....*....|....*....|....*....|....*
gi 547261035 336 GLALVKTFVEEAGGSITLESRPGR-TDFTVLLPLE 369
Cdd:PRK15347 581 GLTIASSLAKMMGGELTLFSTPGVgSCFSLVLPLN 615
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
255-367 |
1.13e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 69.72 E-value: 1.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 255 FTQVFLNLARNAAEAMTEGrahgtAVIIFKTRIAR-----DVMLAGTRTRTALRIDVVDNGPGVPEHLKERIFFPLVT-- 327
Cdd:cd16919 1 LELAILNLAVNARDAMPEG-----GRLTIETSNQRvdadyALNYRDLIPGNYVCLEVSDTGSGMPAEVLRRAFEPFFTtk 75
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 547261035 328 GRAEGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLP 367
Cdd:cd16919 76 EVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVgTTVRIYLP 116
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
135-368 |
1.37e-14 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 75.33 E-value: 1.37e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 135 RDAIAEAGRA--ANSELLRNLAHEIKNPLGGIRGAAQLLESELVRDEDRECTNVILEEAARLQELVDRLLMPYRTPAAAG 212
Cdd:PRK11466 431 RQARAEAEKAsqAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTILNDILDYSAIEAGGK 510
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 213 PVNIHEVLEHVRSLI--GLEFAQGLTIER------DYDISAPAVF-GDRGRFTQVFLNLARNAAEAMTEGrahgtaVIIF 283
Cdd:PRK11466 511 NVSVSDEPFEPRPLLesTLQLMSGRVKGRpirlatDIADDLPTALmGDPRRIRQVITNLLSNALRFTDEG------SIVL 584
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 284 KTRIardvmlagtrTRTALRIDVVDNGPGVPEHLKERIFFPLV--TGRAEGSGLGLALVKTFVEEAGGSITLESRPGR-T 360
Cdd:PRK11466 585 RSRT----------DGEQWLVEVEDSGCGIDPAKLAEIFQPFVqvSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVgS 654
|
....*...
gi 547261035 361 DFTVLLPL 368
Cdd:PRK11466 655 CFCLRLPL 662
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
145-202 |
1.57e-14 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 67.62 E-value: 1.57e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 547261035 145 ANSELLRNLAHEIKNPLGGIRGAAQLLESELVRDEDRECTNVILEEAARLQELVDRLL 202
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLL 58
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
125-369 |
2.89e-13 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 71.42 E-value: 2.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 125 VDLDDA-LRAErdaiaEAGRAaNSELLRNLAHEIKNPLGGIRG-AAQLLESELV---RDE----DRECTNV------ILE 189
Cdd:PRK11107 277 VELDLAkKRAQ-----EAARI-KSEFLANMSHELRTPLNGVIGfTRQTLKTPLTptqRDYlqtiERSANNLlaiindILD 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 190 ----EAARLqelvdrLL--MPYrtpaaagpvNIHEVLEHVRSLI-------GLEfaqgLTIERDYDISaPAVFGDRGRFT 256
Cdd:PRK11107 351 fsklEAGKL------VLenIPF---------SLRETLDEVVTLLahsahekGLE----LTLNIDPDVP-DNVIGDPLRLQ 410
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 257 QVFLNLARNAAEaMTEgraHGTAVIIFKTRiardvmlAGTRTRTALRIDVVDNGPGVPEHLKERIFFPL------VTGRA 330
Cdd:PRK11107 411 QIITNLVGNAIK-FTE---SGNIDILVELR-------ALSNTKVQLEVQIRDTGIGISERQQSQLFQAFrqadasISRRH 479
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 547261035 331 EGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPLE 369
Cdd:PRK11107 480 GGTGLGLVITQKLVNEMGGDISFHSQPNRgSTFWFHLPLD 519
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
145-202 |
3.97e-13 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 63.74 E-value: 3.97e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 547261035 145 ANSELLRNLAHEIKNPLGGIRGAAQLLESELVRDEDRECTNVILEEAARLQELVDRLL 202
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLL 58
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
152-375 |
4.23e-13 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 70.43 E-value: 4.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 152 NLAHEIKNPLGGIRGAAQLLEsELVRDEDRECTNVILEEAARLQELVDRL---------LMPYRTpaaaGPVNIHEVLEH 222
Cdd:PRK10549 246 DISHELRTPLAVLRGELEAIQ-DGVRKFTPESVASLQAEVGTLTKLVDDLhqlslsdegALAYRK----TPVDLVPLLEV 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 223 VRSLIGLEFAQ-GLTIERDYDISAPaVFGDRGRFTQVFLNLARNAAEAMTEGRAhgtaviifktriardVMLAGTRTRTA 301
Cdd:PRK10549 321 AGGAFRERFASrGLTLQLSLPDSAT-VFGDPDRLMQLFNNLLENSLRYTDSGGS---------------LHISAEQRDKT 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 302 LRIDVVDNGPGVPEHLKERIF--FPlvtgRAE--------GSGLGLALVKTFVEEAGGSITLESRP-GRTDFTVLLPLEG 370
Cdd:PRK10549 385 LRLTFADSAPGVSDEQLQKLFerFY----RTEgsrnrasgGSGLGLAICLNIVEAHNGRIIAAHSPfGGVSITVELPLER 460
|
....*
gi 547261035 371 REARE 375
Cdd:PRK10549 461 DLQRE 465
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
144-202 |
1.05e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 62.62 E-value: 1.05e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 144 AANSELLRNLAHEIKNPLGGIRGAAQLLESELVRDED-RECTNVILEEAARLQELVDRLL 202
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEqREYLERIREEAERLLRLINDLL 61
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
261-367 |
1.07e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 63.85 E-value: 1.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 261 NLARNAAEAMTEGRAHGTAVIIFKTRIARDVMlagtrtrtalrIDVVDNGPGVPEHLKERIFFPLVTGRAEGS-GLGLAL 339
Cdd:cd16915 7 NLIDNALDALAATGAPNKQVEVFLRDEGDDLV-----------IEVRDTGPGIAPELRDKVFERGVSTKGQGErGIGLAL 75
|
90 100
....*....|....*....|....*....
gi 547261035 340 VKTFVEEAGGSITLES-RPGRTDFTVLLP 367
Cdd:cd16915 76 VRQSVERLGGSITVESePGGGTTFSIRIP 104
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
117-380 |
1.12e-12 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 69.76 E-value: 1.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 117 GTTALLEVVDLDDALRAERDAIAEAgRAANSELLRNLAHEIKNPLGGIRGAAQLLESELVRDEDR-ECTNVILEEAARLQ 195
Cdd:PRK09959 684 GWQDITETRDLIHALEVERNKAINA-TVAKSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRvEAISLAYATGQSLL 762
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 196 ELVDRLLMPYRTPAAAGP-----VNIHEVLEHVRSLIGlefaqGLTIERDYDISAPAVFGDR-------GRFTQVFLNLA 263
Cdd:PRK09959 763 GLIGEILDVDKIESGNYQlqpqwVDIPTLVQNTCHSFG-----AIAASKSIALSCSSTFPDHylvkidpQAFKQVLSNLL 837
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 264 RNAAEAMTEGrahgtAVIIFKTRIARDvmlagtRTRTALRIDVVDNGPGVPEHLKERIF---FPLVTGRAE-GSGLGLAL 339
Cdd:PRK09959 838 SNALKFTTEG-----AVKITTSLGHID------DNHAVIKMTIMDSGSGLSQEEQQQLFkrySQTSAGRQQtGSGLGLMI 906
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 547261035 340 VKTFVEEAGGSITLESRPG-RTDFTVLLPLEGREARENREAK 380
Cdd:PRK09959 907 CKELIKNMQGDLSLESHPGiGTTFTITIPVEISQQVATVEAK 948
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
304-366 |
8.84e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 61.76 E-value: 8.84e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 304 IDVVDNGPGVPEHLKERIFFPLVT------GRAEGSGLGLALVKTFVEEAGGSITLESRPG-RTDFTVLL 366
Cdd:cd16947 55 IDIWDKGKGISETEKDHVFERLYTledsrnSAKQGNGLGLTITKRLAESMGGSIYVNSKPYeKTVFTVTL 124
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
135-380 |
9.33e-12 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 66.23 E-value: 9.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 135 RDAIAEAGRAANSELLRNL----AHEIKNPLGGIRGAAQLLESELVR-DEDRE----CTNVILEEAARLQELVDRLLMPY 205
Cdd:PRK13557 148 RDAEDALRQAQKMEALGQLtggiAHDFNNLLQVMSGYLDVIQAALSHpDADRGrmarSVENIRAAAERAATLTQQLLAFA 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 206 RTPAAAG-PVNIHEVLEHVRSLIGLEFAQGLTIERDYdisAPAVFGDRGRFTQV---FLNLARNAAEAMTEGrahGTAVI 281
Cdd:PRK13557 228 RKQRLEGrVLNLNGLVSGMGELAERTLGDAVTIETDL---APDLWNCRIDPTQAevaLLNVLINARDAMPEG---GRVTI 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 282 IFKTRIARD---VMLAGTRTRTALRIDVVDNGPGVPEHLKERIFFPLVTGRAE--GSGLGLALVKTFVEEAGGSITLESR 356
Cdd:PRK13557 302 RTRNVEIEDedlAMYHGLPPGRYVSIAVTDTGSGMPPEILARVMDPFFTTKEEgkGTGLGLSMVYGFAKQSGGAVRIYSE 381
|
250 260
....*....|....*....|....
gi 547261035 357 PGRTDfTVLLPLEGREARENREAK 380
Cdd:PRK13557 382 VGEGT-TVRLYFPASDQAENPEQE 404
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
302-372 |
1.52e-11 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 65.70 E-value: 1.52e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 547261035 302 LRIDVVDNGPGVPEHLKERIFFPLVTGRAEGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPLEGRE 372
Cdd:PRK11086 468 LHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVgTQFFVQIPWDGER 539
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
148-367 |
3.57e-11 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 64.47 E-value: 3.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 148 ELLRNLAHEIKNPLGGIRGAAQLLESELVRDedrectnVILEEAARLQELVDRLLMPYRTPAAAGPV--NIHEVLEhvrs 225
Cdd:PRK15053 340 ESLRTLRHEHLNWMSTLNGLLQMKEYDRVLE-------MVQGESQAQQQLIDSLREAFADRQVAGLLfgKVQRARE---- 408
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 226 lIGLEfaqgLTIERDYDISAPAVFGDRGRFTQVFLNLARNAAEAMTEGRAHGTAVIIFKTRIARDVMlagtrtrtalrID 305
Cdd:PRK15053 409 -LGLK----MVIVPGSQLSQLPPGLDSTEFAAIVGNLLDNAFEASLRSDEGNKIVELFLSDEGDDVV-----------IE 472
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 547261035 306 VVDNGPGVPEHLKERIFFPLVTGRAEGS---GLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLP 367
Cdd:PRK15053 473 VADQGCGVPESLRDKIFEQGVSTRADEPgehGIGLYLIASYVTRCGGVITLEDNDPCgTLFSIFIP 538
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
139-369 |
9.16e-11 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 63.52 E-value: 9.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 139 AEAGR-AANSELLRN-----LAHEIKNPLGGIRGAAQLLESELVRDEDRECT--NVILEEAARLQELVDRLLMPYRTpaA 210
Cdd:PRK10490 651 EEQARlASEREQLRNallaaLSHDLRTPLTVLFGQAEILTLDLASEGSPHARqaSEIRQQVLNTTRLVNNLLDMARI--Q 728
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 211 AGPVNIHEVLEHVRSLIG-----LEFA-QGLTIERDYDISAPAVFGDRGRFTQVFLNLARNAAEamtegRAHGTAVIIFK 284
Cdd:PRK10490 729 SGGFNLRKEWLTLEEVVGsalqmLEPGlSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVK-----YAGAQAEIGID 803
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 285 TRIARDvmlagtrtrtALRIDVVDNGPGVPEHLKERIFFPLVTGRAE----GSGLGLALVKTFVEEAGGSITLESRP-GR 359
Cdd:PRK10490 804 AHVEGE----------RLQLDVWDNGPGIPPGQEQLIFDKFARGNKEsaipGVGLGLAICRAIVEVHGGTIWAENRPeGG 873
|
250
....*....|
gi 547261035 360 TDFTVLLPLE 369
Cdd:PRK10490 874 ACFRVTLPLE 883
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
257-367 |
3.36e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 56.57 E-value: 3.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 257 QVFLNLARNAAEAMTEGRAhgtaviifktriaRDVMLAGTRTRTALRIDVVDNGPGVPEHLKERIF--FPLVTGRA--EG 332
Cdd:cd16921 3 QVLTNLLGNAIKFRRPRRP-------------PRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFgiFQRLHSREeyEG 69
|
90 100 110
....*....|....*....|....*....|....*.
gi 547261035 333 SGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLP 367
Cdd:cd16921 70 TGVGLAIVRKIIERHGGRIWLESEPGEgTTFYFTLP 105
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
289-368 |
5.30e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 56.18 E-value: 5.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 289 RDVMLAGTRTRTALRIDVVDNGPGVPEHLKERIFFPL------VTGRAEGSGLGLALVKTFVEEAGGSITLESR-PGRTD 361
Cdd:cd16949 18 SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFyrvdsaRDRESGGTGLGLAIAERAIEQHGGKIKASNRkPGGLR 97
|
....*..
gi 547261035 362 FTVLLPL 368
Cdd:cd16949 98 VRIWLPA 104
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
257-358 |
9.87e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 55.16 E-value: 9.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 257 QVFLNLARNAAEAMtEGRAHGtaviifKTRIARDVmLAGtrtRTALRidVVDNGPGVPEHLKERIFFPLVTGR--AEGSG 334
Cdd:cd16976 3 QVLMNLLQNALDAM-GKVENP------RIRIAARR-LGG---RLVLV--VRDNGPGIAEEHLSRVFDPFFTTKpvGKGTG 69
|
90 100
....*....|....*....|....
gi 547261035 335 LGLALVKTFVEEAGGSITLESRPG 358
Cdd:cd16976 70 LGLSISYGIVEEHGGRLSVANEEG 93
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
134-355 |
1.08e-09 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 60.09 E-value: 1.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 134 ERDAIAEAGRAANSEL------------LRNLAHEIKNPLGGIR-------------GAAQLLESelvrdedrectnviL 188
Cdd:COG4192 409 ERKRIEKNLRQTQDELiqaakmavvgqtMTSLAHELNQPLNAMSmylfsakkaleqeNYAQLPTS--------------L 474
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 189 EEAARLQELVDRLLMPYRTPAAAG-----PVNIHEVLEHVRSLIGLEFA--QG-LTIERDydisaPAVFGDRGRFTQVFL 260
Cdd:COG4192 475 DKIEGLIERMDKIIKSLRQFSRKSdtplqPVDLRQVIEQAWELVESRAKpqQItLHIPDD-----LMVQGDQVLLEQVLV 549
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 261 NLARNAAEAMTEgrahgtaviifktriARDVMLAGTRTRTALRIDVVDNGPGVPehLKERIFFPLVTGRAEGSGLGLALV 340
Cdd:COG4192 550 NLLVNALDAVAT---------------QPQISVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFTTTKEVGLGLGLSIC 612
|
250
....*....|....*
gi 547261035 341 KTFVEEAGGSITLES 355
Cdd:COG4192 613 RSIMQQFGGDLYLAS 627
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
251-367 |
1.11e-09 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 55.58 E-value: 1.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 251 DRGRFTQVFLNLARNAAEAMTEGrahgtaviifkTRIArdVMLAGTRTRTALrIDVVDNGPGVPEHLKERIF--FPLVTG 328
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDG-----------GRIR--CILEKFRLNRFL-LTVSDSGPGIPPNLREEIFerFRQGDG 66
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 547261035 329 RAE----GSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLP 367
Cdd:cd16925 67 SSTrahgGTGLGLSIVKEFVELHGGTVTVSDAPGGgALFQVELP 110
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
152-367 |
1.81e-09 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 58.87 E-value: 1.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 152 NLAHEIKNPLGGIRGAAQLLESELVRDEDRE-CTNVILEEAARLQELVDRLLMPYRTPAAAGpVNIHEVLEHVRSLIGLE 230
Cdd:PRK11006 210 NVSHELRTPLTVLQGYLEMMQDQPLEGALREkALHTMREQTQRMEGLVKQLLTLSKIEAAPT-IDLNEKVDVPMMLRVLE 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 231 F-AQGLTIER---DYDISAP-AVFGDRGRFTQVFLNLARNAAEAMTEGrahgtaviifkTRIardvMLAGTRTRTALRID 305
Cdd:PRK11006 289 ReAQTLSQGKhtiTFEVDNSlKVFGNEDQLRSAISNLVYNAVNHTPEG-----------THI----TVRWQRVPQGAEFS 353
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 306 VVDNGPGV-PEH---LKERiFFPLVTGRAE---GSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLP 367
Cdd:PRK11006 354 VEDNGPGIaPEHiprLTER-FYRVDKARSRqtgGSGLGLAIVKHALSHHDSRLEIESEVGKgTRFSFVLP 422
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
153-368 |
4.23e-09 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 58.41 E-value: 4.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 153 LAHEIKNPLGGIRGAAQ-LLESELvRDEDRECTNVILEEAARLQEL---------VDRllmpYRTPAAAGPVNIHEVLEH 222
Cdd:PRK11091 290 ISHELRTPLNGIVGLSRiLLDTEL-TAEQRKYLKTIHVSAITLGNIfndiidmdkMER----RKLQLDNQPIDFTDFLAD 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 223 VRSLIGLEFAQ-GL--TIERDYDISApAVFGDRGRFTQVFLNLARNAAEAMTEGRahgtaVIIfktRIARDvmlagtrTR 299
Cdd:PRK11091 365 LENLSGLQAEQkGLrfDLEPLLPLPH-KVITDGTRLRQILWNLISNAVKFTQQGG-----VTV---RVRYE-------EG 428
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 547261035 300 TALRIDVVDNGPGVPEHLKERIF-----FPLVTG--RAEGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPL 368
Cdd:PRK11091 429 DMLTFEVEDSGIGIPEDELDKIFamyyqVKDSHGgkPATGTGIGLAVSKRLAQAMGGDITVTSEEGKgSCFTLTIHA 505
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
302-358 |
4.05e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 50.91 E-value: 4.05e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 547261035 302 LRIDVVDNGPGVPEHLKERIFFPLVTGRA----EGSGLGLALVKTFVEEAGGSITLESRPG 358
Cdd:cd16950 31 TRIQVLDNGPGIAPEEVDELFQPFYRGDNargtSGTGLGLAIVQRISDAHGGSLTLANRAG 91
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
304-358 |
6.12e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 50.48 E-value: 6.12e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 547261035 304 IDVVDNGPGVPEHLKERI---FFPLVTGRAEGSGLGLALVKTFVEEAGGSITLESRPG 358
Cdd:cd16940 47 IRVEDNGPGIDEEELEALferFYRSDGQNYGGSGLGLSIVKRIVELHGGQIFLGNAQG 104
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
251-367 |
6.79e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 50.15 E-value: 6.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 251 DRGRFTQVFLNLARNAAEAMTEGrahGTaviifktriardVMLAGTRTRTALRIDVVDNGPGVPE----HLKERiFFPLV 326
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTG---GK------------LRIRAAQTPQEVRLDVEDSAPGVSDdqlaRLFER-FYRVE 64
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 547261035 327 TGR---AEGSGLGLALVKTFVEEAGGSITLESRP-GRTDFTVLLP 367
Cdd:cd16946 65 SSRnraSGGSGLGLAICHNIALAHGGTISAEHSPlGGLRLVLTLP 109
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
297-357 |
1.04e-07 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 53.38 E-value: 1.04e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 547261035 297 RTRTALRIDVVDNGPGVPEHLKERIFFPLVTG-RA---EGSGLGLALVKTFVEEAGGSITLESRP 357
Cdd:PRK09467 357 TEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGdSArgsSGTGLGLAIVKRIVDQHNGKVELGNSE 421
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
152-367 |
1.17e-07 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 53.62 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 152 NLAHEIKNPLGGIrgaaqLLESELVRDEDR---ECTNVI---LEEAARLQELV-DRL---------LMPYRTPaaagpVN 215
Cdd:PRK09835 268 DIAHEIRTPITNL-----ITQTEIALSQSRsqkELEDVLysnLEELTRMAKMVsDMLflaqadnnqLIPEKKM-----LD 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 216 IHEVLEHVrsligLEFAQGLTIERD----YDISAPAVFGDRGRFTQVFLNLARNAAEAMTEGRAhgtaVIIFKTRIARDV 291
Cdd:PRK09835 338 LADEVGKV-----FDFFEAWAEERGvelrFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEA----ITVRCQEVDHQV 408
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 292 MLagtrtrtalridVVDNgPGVP---EHLKeRIF--F----PLVTGRAEGSGLGLALVKTFVEEAGGSITLESRPGRTDF 362
Cdd:PRK09835 409 QL------------VVEN-PGTPiapEHLP-RLFdrFyrvdPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRF 474
|
....*
gi 547261035 363 TVLLP 367
Cdd:PRK09835 475 VISLP 479
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
288-368 |
2.52e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 48.58 E-value: 2.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 288 ARDVMLAGTRTRTALRIDVVDNGPGVPEHLKERIFFPLV------TGRAEGSGLGLALVKTFVEEAGGSITLESRP-GRT 360
Cdd:cd16939 17 HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpsrDRATGGFGLGLAIVHRVALWHGGHVECDDSElGGA 96
|
....*...
gi 547261035 361 DFTVLLPL 368
Cdd:cd16939 97 CFRLTWPR 104
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
149-371 |
2.92e-07 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 52.24 E-value: 2.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 149 LLRNLAHEIKNPLGGIRGAAQLL-----ES-ELVRdedrectnvILEEAARLQELVDRLLMPYRTPaaagpVNIHEVLE- 221
Cdd:PRK09470 246 LLSDISHELRTPLTRLQLATALLrrrqgESkELER---------IETEAQRLDSMINDLLVLSRNQ-----QKNHLEREt 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 222 -HVRSLIG--LEFAQ------GLTIERDYDISAPAVFGDRGRFTQVFLNLARNAAEamtegRAHGTAVIIFKTriardvm 292
Cdd:PRK09470 312 fKANSLWSevLEDAKfeaeqmGKSLTVSAPPGPWPINGNPNALASALENIVRNALR-----YSHTKIEVAFSV------- 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 293 lagtrTRTALRIDVVDNGPGVPEHLKERIFFPLV---TGRAE---GSGLGLALVKTFVEEAGGSITLESRP-GRTDFTVL 365
Cdd:PRK09470 380 -----DKDGLTITVDDDGPGVPEEEREQIFRPFYrvdEARDResgGTGLGLAIVENAIQQHRGWVKAEDSPlGGLRLTIW 454
|
....*.
gi 547261035 366 LPLEGR 371
Cdd:PRK09470 455 LPLYKR 460
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
17-63 |
9.43e-07 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 45.85 E-value: 9.43e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 547261035 17 LFDALAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLPE 63
Cdd:smart00091 6 ILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHP 52
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
303-367 |
2.86e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 45.66 E-value: 2.86e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 547261035 303 RIDVVDNGPGV-PEH---LKERiFFPLVTGRAE---GSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLP 367
Cdd:cd16952 34 RLSVEDTGPGIpPEHiprLTER-FYRVDIERCRntgGTGLGLAIVKHVMSRHDARLLIASELGKgSRFTCLFP 105
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
291-371 |
3.21e-06 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 48.86 E-value: 3.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 291 VMLAGTRTRTALRIDVVDNGPGVPEHLKERIFFPLVTGRaEGSGLGLALVK-----TFVEEAGgsITLESRPGR-TDFTV 364
Cdd:COG2972 362 IRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKG-EGRGIGLRNVRerlklYYGEEYG--LEIESEPGEgTTVTI 438
|
....*..
gi 547261035 365 LLPLEGR 371
Cdd:COG2972 439 RIPLEEE 445
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-367 |
3.54e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 45.07 E-value: 3.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 258 VFLNLARNAAE-AMTEGRAHGTAVIifktriardvmlagtrTRTALRIDVVDNGPGVPEHLKERIFFPLVTG----RAEG 332
Cdd:cd16923 4 VFSNLLSNAIKySPENTRIYITSFL----------------TDDVVNIMFKNPSSHPLDFKLEKLFERFYRGdnsrNTEG 67
|
90 100 110
....*....|....*....|....*....|....*
gi 547261035 333 SGLGLALVKTFVEEAGGSITLESRPGRTDFTVLLP 367
Cdd:cd16923 68 AGLGLSIAKAIIELHGGSASAEYDDNHDLFKVRLP 102
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
257-367 |
3.85e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 45.26 E-value: 3.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 257 QVFLNLARNAAEAMTEGRAHGTaviifktriardVMLAGTRTRtaLRIDVVDNGPGVPEHLKERIFFPLVTGRAEG---- 332
Cdd:cd16953 3 QVLRNLIGNAISFSPPDTGRIT------------VSAMPTGKM--VTISVEDEGPGIPQEKLESIFDRFYTERPANeafg 68
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 547261035 333 --SGLGLALVKTFVEEAGGSITLESR--PGRTD---FTVLLP 367
Cdd:cd16953 69 qhSGLGLSISRQIIEAHGGISVAENHnqPGQVIgarFTVQLP 110
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
294-368 |
9.97e-06 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 47.29 E-value: 9.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 294 AGTRTRTALRID-------VVDNGPGVPEHLKERIFFPLV-----TGRAEGS-GLGLALVKTFVEEAGGSITLESRP-GR 359
Cdd:PRK10604 335 AHSRVRVSLLLDgnqacliVEDDGPGIPPEERERVFEPFVrldpsRDRATGGcGLGLAIVHSIALAMGGSVNCDESElGG 414
|
....*....
gi 547261035 360 TDFTVLLPL 368
Cdd:PRK10604 415 ARFSFSWPV 423
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
242-357 |
1.90e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 43.77 E-value: 1.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 242 DISAPAVF-GDRGRFTQVFLNLARNAaeamtegrahgtaviiFKTRIARdVMLAGTRTRTALRIDVVDNGPGVPEHLKER 320
Cdd:cd16954 24 DISPELRFpGERNDLMELLGNLLDNA----------------CKWCLEF-VEVTARQTDGGLHLIVDDDGPGVPESQRSK 86
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 547261035 321 IFfplVTG-RAE----GSGLGLALVKTFVEEAGGSITLESRP 357
Cdd:cd16954 87 IF---QRGqRLDeqrpGQGLGLAIAKEIVEQYGGELSLSDSP 125
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
139-368 |
2.03e-05 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 46.89 E-value: 2.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 139 AEAGRAANSELLRNLAHEIKNPLGGIRGAAQLLES-ELVRDEDRECTNV-------------ILE----EAARLQelvdr 200
Cdd:PRK10841 440 AEQASQSKSMFLATVSHELRTPLYGIIGNLDLLQTkELPKGVDRLVTAMnnssslllkiisdILDfskiESEQLK----- 514
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 201 lLMPyrtpaaaGPVNIHEVLEHVRS-LIGLEFAQGLT----IERDydisAP-AVFGDRGRFTQVFLNLARNAAEaMTEgr 274
Cdd:PRK10841 515 -IEP-------REFSPREVINHITAnYLPLVVKKRLGlycfIEPD----VPvALNGDPMRLQQVISNLLSNAIK-FTD-- 579
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 275 ahgTAVIIFKTRIARDVmlagtrtrtaLRIDVVDNGPGVPEHLKERIFFPLV---TG--RA-EGSGLGLALVKTFVEEAG 348
Cdd:PRK10841 580 ---TGCIVLHVRVDGDY----------LSFRVRDTGVGIPAKEVVRLFDPFFqvgTGvqRNfQGTGLGLAICEKLINMMD 646
|
250 260
....*....|....*....|.
gi 547261035 349 GSITLESRPGR-TDFTVLLPL 368
Cdd:PRK10841 647 GDISVDSEPGMgSQFTIRIPL 667
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
302-358 |
3.50e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 42.45 E-value: 3.50e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 547261035 302 LRIDVVDNGPGVPEHLKERIF-----FPLVTGRAEGSGLGLALVKTFVEEAGGSITLESRPG 358
Cdd:cd16945 37 IELLVFDEGSGIPDYALNRVFerfysLPRPHSGQKSTGLGLAFVQEVAQLHGGRITLRNRPD 98
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
5-373 |
4.15e-05 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 45.28 E-value: 4.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 5 ESLTDAVGTSFDLFDALAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLPEAAGWFRRRAAAPGAVEAASFM 84
Cdd:COG3920 154 AELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRL 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 85 LPAVEFLRGLLPSVRVRASFSSLSPKPSNAPSGTTALLEVVDLDDALRAERDAIAEAGRAANSELLRNLAHEIKNPLGGI 164
Cdd:COG3920 234 RAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKELLLRELHHRVKNNLQVV 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 165 RGAAQL----LESELVRDEDRECTNVIL--------------EEAARLQELVDRLLMPYRTPAAAGPVNIHEVLEHVRsl 226
Cdd:COG3920 314 SSLLRLqarrADDPEAREALEESQNRIQalalvhellyqsedWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDVE-- 391
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 227 IGLEFAQGLTIerdydisapavfgdrgrftqvFLN-LARNAAEamtegraHGtaviiFKTRIARDVMLAGTRTRTALRID 305
Cdd:COG3920 392 LPADAAVPLGL---------------------ILNeLVTNALK-------HA-----FLSGEGGRIRVSWRREDGRLRLT 438
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 547261035 306 VVDNGPGVPEHLKERiffplvtgraEGSGLGLALVKTFVEEAGGSITLESRPGrTDFTVLLPLEGREA 373
Cdd:COG3920 439 VSDNGVGLPEDVDPP----------ARKGLGLRLIRALVRQLGGTLELDRPEG-TRVRITFPLAELAA 495
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
17-63 |
6.44e-05 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 40.61 E-value: 6.44e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 547261035 17 LFDALAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLPE 63
Cdd:pfam13188 6 LFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLLDP 52
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
17-63 |
1.15e-04 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 43.99 E-value: 1.15e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 547261035 17 LFDALAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLPE 63
Cdd:COG3829 16 ILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPN 62
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
21-63 |
1.28e-04 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 40.69 E-value: 1.28e-04
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 547261035 21 LAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLPE 63
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHP 43
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
242-357 |
1.60e-04 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 43.47 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 242 DISAPAVF-GDRGRFTQVFLNLARNAAEAMTEgrahgtaviiFktriardVMLAGTRTRTALRIDVVDNGPGVPEHLKER 320
Cdd:PRK10815 365 DISPEITFvGEKNDFMEVMGNVLDNACKYCLE----------F-------VEISARQTDEHLHIVVEDDGPGIPESKREL 427
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 547261035 321 IFfplVTG-RAE----GSGLGLALVKTFVEEAGGSITLESRP 357
Cdd:PRK10815 428 IF---DRGqRADtlrpGQGLGLSVAREITEQYEGKISAGDSP 466
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
18-66 |
2.09e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 40.48 E-value: 2.09e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 547261035 18 FDALAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLPEAAG 66
Cdd:pfam08448 1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDA 49
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
306-367 |
4.16e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 39.58 E-value: 4.16e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 547261035 306 VVDNGPGVPEHLKERIFFPLVTGR-----AEGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLP 367
Cdd:cd16948 42 IKDFGIGIPEEDLPRVFDKGFTGEngrnfQESTGMGLYLVKKLCDKLGHKIDVESEVGEgTTFTITFP 109
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
118-360 |
4.44e-04 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 41.88 E-value: 4.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 118 TTAL-LEVVDLDDALRAERDAIAEAgraansellrnlAHEIKNPLGGIRGAAQLLESELVRDedreCTNVIleeaARLQE 196
Cdd:PRK10755 120 TSALnQLVSRLTSTLDQERLFTADV------------AHELRTPLAGIRLHLELLEKQHHID----VAPLI----ARLDQ 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 197 L---VDRLLMPYRT--PAAAG---PVN-IHEVLEHVRSLIGLEFAQ-GLTIERDYDISAPAVFGDRGRFTQVFLNLARNA 266
Cdd:PRK10755 180 MmhtVEQLLQLARAgqSFSSGhyqTVKlLEDVILPSQDELSEMLEQrQQTLLLPESAADITVQGDATLLRLLLRNLVENA 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 267 AEAMTEGrahgTAVIIfktRIARDVmlagtrtrTALRIDVVDNGPGVPE-HLKE--RIFFPLVTgRAEGSGLGLALVKTF 343
Cdd:PRK10755 260 HRYSPEG----STITI---KLSQED--------GGAVLAVEDEGPGIDEsKCGElsKAFVRMDS-RYGGIGLGLSIVSRI 323
|
250
....*....|....*..
gi 547261035 344 VEEAGGSITLESRPGRT 360
Cdd:PRK10755 324 TQLHHGQFFLQNRQERS 340
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
17-63 |
5.13e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 39.32 E-value: 5.13e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 547261035 17 LFDALAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLPE 63
Cdd:pfam00989 6 ILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPE 52
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
332-367 |
9.98e-04 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 39.87 E-value: 9.98e-04
10 20 30
....*....|....*....|....*....|....*..
gi 547261035 332 GSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLP 367
Cdd:cd16916 142 GRGVGMDVVKRSIESLGGTIEVESEPGQgTTFTIRLP 178
|
|
| TyrR |
COG3283 |
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ... |
17-62 |
1.16e-03 |
|
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];
Pssm-ID: 442513 [Multi-domain] Cd Length: 514 Bit Score: 40.94 E-value: 1.16e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 547261035 17 LFDALAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLP 62
Cdd:COG3283 85 LLEALPDPVFSIDLKGKIELANPAALSLLGLSEEELIGQPLSELLK 130
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
298-358 |
1.63e-03 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 40.40 E-value: 1.63e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 547261035 298 TRTALRIDVVDNGPGV-PEHLK---ERIFFPlvTGR-AEGSGLGLALVKTFVEEAGGSITLESRPG 358
Cdd:PRK10337 377 TLNARNFTVRDNGPGVtPEALArigERFYRP--PGQeATGSGLGLSIVRRIAKLHGMNVSFGNAPE 440
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
132-371 |
2.24e-03 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 39.22 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 132 RAERDAIAEAGRAANSELLR-------NLAHEiknpLGGIRGAAQLLESELVRDED--RECTNVILEEAARLQELVDRLL 202
Cdd:COG4585 37 ELERELAARAEEAREEERRRiarelhdGVGQS----LSAIKLQLEAARRLLDADPEaaREELEEIRELAREALAELRRLV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 203 MPYRTPAAAGpvniHEVLEHVRSLI-GLEFAQGLTIERDYDISAPAVFGDrgrftqVFLNLARNAAEAMTEGRAHGTAvi 281
Cdd:COG4585 113 RGLRPPALDD----LGLAAALEELAeRLLRAAGIRVELDVDGDPDRLPPE------VELALYRIVQEALTNALKHAGA-- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547261035 282 ifkTRIarDVMLagTRTRTALRIDVVDNGPGVPehlkeriffplvTGRAEGSGLGLALVKTFVEEAGGSITLESRPGR-T 360
Cdd:COG4585 181 ---TRV--TVTL--EVDDGELTLTVRDDGVGFD------------PEAAPGGGLGLRGMRERAEALGGTLTIGSAPGGgT 241
|
250
....*....|.
gi 547261035 361 DFTVLLPLEGR 371
Cdd:COG4585 242 RVRATLPLAAA 252
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
296-367 |
3.71e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 36.38 E-value: 3.71e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 547261035 296 TRTRTALRIDVVDNGPGVPEHLKERiffplvtgraeGSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLP 367
Cdd:cd16917 26 SYTADELTLTVVDDGVGFDGPAPPG-----------GGGFGLLGMRERAELLGGTLTIGSRPGGgTRVTARLP 87
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
17-66 |
3.83e-03 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 38.85 E-value: 3.83e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 547261035 17 LFDALAEAVFLLDDEGRITSANAAAETLIGRTRRALSGVDVAEFLPEAAG 66
Cdd:COG2202 142 LVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDR 191
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
332-368 |
4.09e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 39.01 E-value: 4.09e-03
10 20 30
....*....|....*....|....*....|....*...
gi 547261035 332 GSGLGLALVKTFVEEAGGSITLESRPGR-TDFTVLLPL 368
Cdd:COG0643 381 GRGVGMDVVKTNIEALGGTIEIESEPGKgTTFTLRLPL 418
|
|
| |
