|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
19-445 |
8.26e-118 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 351.38 E-value: 8.26e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 19 KILFFALPLAASSILQQLFNSADVAVVGRFAGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKVKEAV 98
Cdd:cd13138 4 TLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKAV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 99 HTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCLIISG 178
Cdd:cd13138 84 GTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVIIAC 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 179 IINILLNLLLVIVFHLSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVKVIKIGAPAGLQGVVFSL 258
Cdd:cd13138 164 VLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLKDFRFDKEILKEILKIGLPSALQQSLVSI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 259 SNVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGMALTLVMSFIFV 338
Cdd:cd13138 244 SFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLVF 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 339 GATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVIGSCGFRVVWLYTVFKVVP-TF 417
Cdd:cd13138 324 FFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLSRLTGlGL 403
|
410 420
....*....|....*....|....*...
gi 547471031 418 TMLMNVYPVTWVITGTMVMTSYLIIRKR 445
Cdd:cd13138 404 FGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
11-436 |
1.49e-88 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 276.25 E-value: 1.49e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 11 MIHGPMFYKILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGR 90
Cdd:COG0534 1 LTEGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGRL-GTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 91 EDKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKP 170
Cdd:COG0534 80 REEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 171 LYCLIISGIINILLNLLLVIVFHLSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVKVIKIGAPAG 250
Cdd:COG0534 160 MIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 251 LQGVVFSLSNVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGMALT 330
Cdd:COG0534 240 LQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 331 LVMSFIFVGATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVIGSCGFRVVWLYTV 410
Cdd:COG0534 320 LLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLL 399
|
410 420
....*....|....*....|....*.
gi 547471031 411 FKVVPTFTMLMNVYPVTWVITGTMVM 436
Cdd:COG0534 400 AFLGLGLTGVWLALPIGEVLRALLLL 425
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
19-414 |
1.73e-64 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 213.91 E-value: 1.73e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 19 KILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKVKEAV 98
Cdd:cd13137 2 RIWSLAWPVILENLLQTLVGLVDVFMVGRL-GAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 99 HTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCLIISG 178
Cdd:cd13137 81 GQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 179 IINILLNLL----LVIVFHLSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVKVIKIGAPAGLQGV 254
Cdd:cd13137 161 VLNIVLDYVlifgLWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKISFKGFRLDRKIIKKLLRIGLPAGLEQL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 255 VFSLSNVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGMALTLVMS 334
Cdd:cd13137 241 LRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLLG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 335 FIFVGATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVIGSCGFRVVWLYTVFKVV 414
Cdd:cd13137 321 LLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLGFVL 400
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
10-404 |
5.94e-54 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 186.24 E-value: 5.94e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 10 DMIHGPMFYKILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQG 89
Cdd:cd13142 3 NILEGSILRTLLKLAWPIIVSNLLQVAYNLADTFWLGRL-GADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 90 REDKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLM-INTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETR 168
Cdd:cd13142 82 DYDKANKVAGQTFSFVIILSLILAVLGYILSRPLLLLlIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 169 KPLYCLIISGIINILL----NLLLVIVFHLSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVKVIK 244
Cdd:cd13142 162 TPMKIMFGSVLLNVILdpllIFGIGPFPGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKISLRDLKPDWEWLKKIFR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 245 IGAPAGLQGVVFSLSNVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLV 324
Cdd:cd13142 242 IGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAAL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 325 TGMALTLVMSFIFVGATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVIGSCGFRV 404
Cdd:cd13142 322 LIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRI 401
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
14-398 |
4.34e-45 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 162.31 E-value: 4.34e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 14 GPMFYKILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDK 93
Cdd:cd13140 1 GPILKTLLRLALPIMGTSFIQMAYNLTDMFWVGRL-GSDAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 94 VKEAVHTVMSVALISGVSLLVIGIIIAKPILLMIN-TPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLY 172
Cdd:cd13140 80 ARKYARNALQLNLLLGILYGLLLLLFAKPLIGFFNlGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 173 CLIISGIINILLNLLLVIVF----HLSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVKVIKIGAP 248
Cdd:cd13140 160 INAIGLVLNIILDPLLIFGFgpfpALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIKEILKLGLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 249 AGLQGVVFSLSNVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGMA 328
Cdd:cd13140 240 VALQSILFALISMILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASA 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 329 LTLVMSFIFVGATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVIG 398
Cdd:cd13140 320 IGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISIVF 389
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
20-402 |
3.60e-44 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 159.60 E-value: 3.60e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 20 ILFFALPLAASSILQQLFNSADVAVVGRFAGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKVKEAVH 99
Cdd:cd13143 6 FLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRIFS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 100 TVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCLIISGI 179
Cdd:cd13143 86 TALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 180 INILLNLLLVIVFHLSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVKVIKIGAPAGLQGVVFSLS 259
Cdd:cd13143 166 LNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILALGFPSFLMQLSSSVV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 260 NVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMI-NAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGMALTLVMSFIFV 338
Cdd:cd13143 246 TIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPlIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLILL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 547471031 339 GATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVIGSCGF 402
Cdd:cd13143 326 LFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLF 389
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
24-409 |
4.20e-44 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 159.41 E-value: 4.20e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 24 ALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKVKEAVHTVMS 103
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRL-LGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 104 VALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCLIIS---GII 180
Cdd:cd12082 80 LAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSnllNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 181 NILLNLLLVIVFHLSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVKVIKIGAPAGLQGVVFSLSN 260
Cdd:cd12082 160 LDPLLIFGLGPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 261 VFIQSAINGF-GTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGMALTLVMSFIFVG 339
Cdd:cd12082 240 LIIVAIVAAFgGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILL 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 340 ATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVIGSCGFRVVWLYT 409
Cdd:cd12082 320 FPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYV 389
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-405 |
2.22e-40 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 149.57 E-value: 2.22e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 20 ILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKVKEAVH 99
Cdd:cd13134 5 LFALAWPIFIELLLQMLLGTIDTFMLSRY-SDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 100 TVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCLIISGI 179
Cdd:cd13134 84 VALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 180 INILLNLLLVIVFH----LSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVKVIKIGAPAGLQGVV 255
Cdd:cd13134 164 LNIVGNYLLIFGWFglpkLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRPFPKKLLKKILKIGLPSAGEELS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 256 FSLSNVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGMALTLVMSF 335
Cdd:cd13134 244 YNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAVAL 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 336 IFVGATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVIGSCGFRVV 405
Cdd:cd13134 324 LLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVP 393
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-400 |
2.07e-38 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 144.37 E-value: 2.07e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 11 MIHGPMFYKILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGR 90
Cdd:cd13149 2 LTEGSIPRHLIKLTLPMIFGILAMLIFNLTDTFFVGKL-GTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 91 EDKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKP 170
Cdd:cd13149 81 RNKAKRLATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 171 LYCLIISGIINILLNLLLVIVF----HLSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVKVIKIG 246
Cdd:cd13149 161 SLVMLGAALVNVILDPILIFGFgpipGMGIAGAAIATVISRALGLGAALYFLHYHHRLIDFSEPSLKALFRSWKDILSIG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 247 APAGLQGVVFSLSNVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTG 326
Cdd:cd13149 241 IPAALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFS 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 547471031 327 MALTLVMSFIFVGATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVIGSC 400
Cdd:cd13149 321 LIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVF 394
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
26-352 |
3.69e-36 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 136.22 E-value: 3.69e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 26 PLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKVKEAVHTVMSVA 105
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHL-GPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 106 LISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCLIISGIINILLN 185
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 186 LLLVIVFH--LSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVKVIKIGAPAGLQGVVFSLSNVFI 263
Cdd:TIGR00797 160 YILIFGKFgfLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 264 QSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGMALTLVMSFIFVGATDF 343
Cdd:TIGR00797 240 ALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREF 319
|
....*....
gi 547471031 344 FAGIYTNDP 352
Cdd:TIGR00797 320 IARLFTNDP 328
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
10-385 |
6.82e-36 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 137.34 E-value: 6.82e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 10 DMIHGPMFYKILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQG 89
Cdd:cd13145 1 DLTKGPIPKLIRKLAIPASVGFFFNTMFNVVDTFFAGKI-STEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 90 REDKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRK 169
Cdd:cd13145 80 DRRKARRYAAQGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 170 PLYCLIISGIINILL----NLLLVIVFHLSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVKVIKI 245
Cdd:cd13145 160 YRNFLIIGFFLNIILdplfIFGGGGIPAMGVSGIALATIISQFIGMFYLLYKVRKSGIISGCRLRDFIPRLDVYKEILKQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 246 GAPAGLQGVVFSLSNVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVT 325
Cdd:cd13145 240 GFPASLNMMTIGLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKY 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 326 GMALTLVMSFIFVGATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGM 385
Cdd:cd13145 320 GFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGL 379
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-404 |
1.72e-35 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 136.21 E-value: 1.72e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 11 MIHGPMFYKILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGR 90
Cdd:cd13144 1 MGSGPVLRLLLTMSIPAMISMLFQALYNIVDSIFVARL-GENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 91 EDKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRI---YFLGMPFVMVYNfgaAILRSTGET 167
Cdd:cd13144 80 QKEANKAANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWcviFSFGMFFQILCE---KVLQSTGNT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 168 RKPLYCLIISGIINILLNLLLVIVFH----LSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVKVI 243
Cdd:cd13144 157 ITPMIAQLIGAIINIILDPILIFGLFgfpaMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRLFRPSLRIIKEIY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 244 KIGAPAGLQGVVFSLSNVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISL 323
Cdd:cd13144 237 AVGLPSIIMQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAI 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 324 VTGMALTLVMSFIFVGATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVIGSCGFR 403
Cdd:cd13144 317 LIAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVL 396
|
.
gi 547471031 404 V 404
Cdd:cd13144 397 L 397
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
19-440 |
4.01e-34 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 132.65 E-value: 4.01e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 19 KILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSpVINLLINM-FVGLSIGANVIIANFIGQGREDKVKEA 97
Cdd:cd13133 6 EILKIALPLVLSMLSQTVMGFTDRAFLGRL-SEVALAASGPAG-VLYFAILMlFFGLSSGVQVFVAQYNGAGRYSRIGRV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 98 VHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPL------ 171
Cdd:cd13133 84 LWQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMvanlvm 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 172 --------YCLI--ISGIinillnlllvivFHLSVAGVAIATVIADGVS-AFLVVYFLSHSDDAIRLNIRELSLNKEIVV 240
Cdd:cd13133 164 vvvnivldYALIfgKLGF------------PAMGIAGAAIATVIAEAVSlLFFLLLLFRRKNRRRFGLRRAWRFDRELLR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 241 KVIKIGAPAGLQGVVFSLSNVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFR 320
Cdd:cd13133 232 RILRLGLPSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTR 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 321 ISLVTGMALTLVMSFIFVGATDFFAGIYTNDP---VAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVI 397
Cdd:cd13133 312 RGLKLALAYMLLLGILFLLFPELLLSIFTPGAdfaLIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELI 391
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 547471031 398 gscgfrVVWLYTVFKVVPTFTMLMNVYPVTWVITGTMVMTSYL 440
Cdd:cd13133 392 ------VAWLYLLPPAYLLVVLGAGLAGAWTVETVYVIVLALI 428
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
20-407 |
5.27e-34 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 131.91 E-value: 5.27e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 20 ILFFALPLAASSILQQLFNSADVAVVGRFAGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKVKEAVH 99
Cdd:cd13136 5 ILALALPAILSNITVPLLGLVDTAVVGHLGSAAYLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAIALLV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 100 TVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVyNFGA-AILRSTGETRKPLYCLIISG 178
Cdd:cd13136 85 RALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLL-NYVAtGWFRGLQDTRTPLILQIVGN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 179 IINILLNLLLVIVFHLSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVKVIKIGAPAGLQGVVFSL 258
Cdd:cd13136 164 VVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSKAALKRLFKLNRDIFIRTLALLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 259 SNVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGMALTLVMSFIFV 338
Cdd:cd13136 244 AFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLALLFF 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 547471031 339 GATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVIGSCGFRVVWL 407
Cdd:cd13136 324 LGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSLAVFLPLLF 392
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
24-446 |
4.92e-33 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 129.58 E-value: 4.92e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 24 ALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKVKE-AVHTVM 102
Cdd:cd13147 15 SIPMIIAMLLQTLYNLVDAIWVAGL-GADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNaAVHSIL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 103 sVALISGVSLLVIGIIIAKPILLMINTpSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCLIISGIINI 182
Cdd:cd13147 94 -LGLIISIILTIVLLPFLEPILVLMGA-GEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSILNI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 183 LLNLLLVIVFHLSVAGVAIATVIADGVSAFLVVY-FLSHSDDAIRLNIRELSLNKEIVVKVIKIGAPAGLQGVVFSLSNV 261
Cdd:cd13147 172 ILDPIFIYTLGLGIAGAAWATVISMLISSLVLLYwFFVKKDTYVSLSLKNFKFDKKIVKDILKVGIPASLEQLIMSVLMI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 262 FIQS-AINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGMALTLVMSFIFVGA 340
Cdd:cd13147 252 ILNLiLVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIELIIAILIFIF 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 341 TDFFAGIYTNDPVAIKYA---IIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVIgscgfRVVWLYTVFKVVPTF 417
Cdd:cd13147 332 APQIAYLFTYSEESAHLApeiVAFLRIMCLFLPFVPFGMMSSSMFQGIGKGLTSLIITIL-----RELIFQVLFAYLFAI 406
|
410 420 430
....*....|....*....|....*....|..
gi 547471031 418 TMLMNVYPVTW-VITGTMV--MTSYLIIRKRI 446
Cdd:cd13147 407 VLGLGLFGVWWgIVLGNAIgsIVGYLWARLYI 438
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-404 |
1.54e-31 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 125.42 E-value: 1.54e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 7 KQMDMIHGPMFYKILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFI 86
Cdd:cd13139 3 KEQDFTSGSLNRAIFLLAIPMVLEMVMESLFAVVDLYFVSRL-GALAIATVGLTESVLTIVYSIAIGLSMAATALVARRI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 87 GQGREDKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGE 166
Cdd:cd13139 82 GEKDPEGAGFAAVQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 167 TRKPLYCLIISGIINILLNLLLVIVF----HLSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVKV 242
Cdd:cd13139 162 AAIAMRSLWLANGLNIILDPLFIFGLgpipAMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQIRRRHLKLDWAIIKKI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 243 IKIGAPAGLQGVVFSLSNVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRIS 322
Cdd:cd13139 242 IKIAVGGILQFLIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 323 LVTGMALTLVMSFIFVGATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVIGSCGF 402
Cdd:cd13139 322 GKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLF 401
|
..
gi 547471031 403 RV 404
Cdd:cd13139 402 QI 403
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
19-398 |
3.62e-30 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 121.45 E-value: 3.62e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 19 KILFFALPLAASSILQQLFNSADVAVVGRfAGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKVKEAV 98
Cdd:cd13131 4 ALLRLALPILIAQLAQMAMGFVDTVMAGR-LGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRRAV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 99 HTVMSVALISGVsLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCLIISG 178
Cdd:cd13131 83 RQGLWLALLLSL-PLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 179 IINILLNLL----LVIVFHLSVAGVAIATVIADGVSAFLVVYFLSHSD--DAIRLNIRELSLNKEIVVKVIKIGAPAGLQ 252
Cdd:cd13131 162 VLNIPLNYVlifgKFGLPALGGAGAGLATAIVYWLMFLALAFYIRRHKrfRRYRLFARFWRPDWARLKELLRLGLPIGLT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 253 ----GVVFSLSNVFIQSaingFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGMA 328
Cdd:cd13131 242 iffeVSLFAAVALLMGR----LGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVG 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 329 LTLVMSFIFVGATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVIG 398
Cdd:cd13131 318 FAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALIS 387
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
19-386 |
2.88e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 104.30 E-value: 2.88e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 19 KILFFALPLAASSILQQLFNSADVAVVGRFAgSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKVKEAV 98
Cdd:cd13135 2 KINHIAIPLILQNLVSQLQMLVDRAFLGRIS-IRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 99 HTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETrKPL--YCLII 176
Cdd:cd13135 81 ISSIVYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGET-KPImyGGIIK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 177 SGIINILLNLLLVIVF---HLSVAGVAIATVIADGVSA-FLVVYFLSHSDDAIRL-NIRELSLNKEIVVKVIKIGAPAGL 251
Cdd:cd13135 160 NLLNVILDYVLIFGNFgfpRLGIIGAAIATTIANVLNLiILVYLCRKIKKLTFKLsNTKVLKANIRPYKFTIKLGLPLGG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 252 QGVVFSLSNVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGMALTL 331
Cdd:cd13135 240 EEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYI 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 547471031 332 VMSFIFVGATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMG 386
Cdd:cd13135 320 AAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIG 374
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
10-395 |
1.39e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 102.39 E-value: 1.39e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 10 DMIHGPMFYKILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVinLLINMFVG--LSIGANVIIANFIG 87
Cdd:cd13141 3 DLTQGSIPKHIISMALPIAIGMIIQTLYFLVDLYFVGQL-GDAALAGVSLAGNV--MFFVMALTqvLNVGTAALVSHAVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 88 QGREDKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLR--IYFLGMPFVMVyNFGAAiLRSTG 165
Cdd:cd13141 80 RKDQGEANAVFNQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYwfIPSLALQFILT-VLGAA-LRGTG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 166 ETRKPLYCLIISGIINILLNLLLVIVF----HLSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVK 241
Cdd:cd13141 158 IVKPFMVIQILAVLLNIILAPILITGWgtgrALGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRLDLALWRPDLPTWKR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 242 VIKIGAPAGLQGVVFSLSNVFIQSAINGFGTHAMAGSSAG--LNYEYFTYYMINAFNQTAVTftSQNYGAKDLERCKRAF 319
Cdd:cd13141 238 LLKIGLPSGGEFLLTFVYMAVIYWALRPFGAAAQAGFGIGsrIMQSLFLPAMAIAFAAPAIA--GQNFGAGNYDRVRETF 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 547471031 320 RISLVTGMALTLVMSFIFVGATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSlLPALLT 395
Cdd:cd13141 316 RITAILTTALMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNT-WPSLLS 390
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-367 |
1.44e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 102.48 E-value: 1.44e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 11 MIHGPMFYKILFFALPLAASSILQQLFNSADVAVVGRF--AGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQ 88
Cdd:cd13146 1 MFSGPISPLLIRLALPILIGQLFQLLYNITDTIWISMIdpSDPALVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 89 GREDKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETR 168
Cdd:cd13146 81 QRAKELDQAADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 169 KPLYCLIISGIINILLNLLLVIVFHLSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVKVIKIGAP 248
Cdd:cd13146 161 YMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHIKLSNISSSVIVEILRVGLP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 249 AGLQGVVFSLSNVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGMA 328
Cdd:cd13146 241 QMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIV 320
|
330 340 350
....*....|....*....|....*....|....*....
gi 547471031 329 LTLVMSFIFVGATDFFAGIYTNDPVAIKYAIIRMKHVTL 367
Cdd:cd13146 321 VVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMAL 359
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
26-177 |
4.55e-22 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 92.24 E-value: 4.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 26 PLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKVKEAVHTVMSVA 105
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHL-GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 547471031 106 LISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCLIIS 177
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS 151
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
12-217 |
1.21e-20 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 93.67 E-value: 1.21e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 12 IHGPMFYKILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGRE 91
Cdd:COG0534 223 PDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARL-GTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDY 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 92 DKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPL 171
Cdd:COG0534 302 DRARRAARLALLLALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPM 381
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 547471031 172 YCLIISGIINILLNLLLVIVFHLSVAGVAIATVIADGVSAFLVVYF 217
Cdd:COG0534 382 IISLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-365 |
1.57e-20 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 93.49 E-value: 1.57e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 11 MIHGPMFYKILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGlSIGANV--IIANFIGQ 88
Cdd:cd13148 5 LLTAPILPTLLRLALPNILALLVQTLVGLAETYFVGQL-GTDALAGVALVFPLLMLTQMMSNG-AMGGGVssAIARALGA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 89 GR-EDKVKEAVHTVMsVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGET 167
Cdd:cd13148 83 GDrERAEALVWHALV-IALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 168 RKPLYCLIISGIINILLNLLLVIVF----HLSVAGVAIATVIADGVSAFLVVYFLSHSDDAIRLNIRELSLNKEIVVKVI 243
Cdd:cd13148 162 RVPALVTLVGAVVQIPLSPGLILGWgplpRLGVAGAAVAAVLYYALAALVLLRYLASGRSRLRLRLRALRLERRLFRDIL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 244 KIGAPAGLQGVVFSLSNVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISL 323
Cdd:cd13148 242 RVGLLAALSPLQTNLTVLLLTGLVGRFGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARARRIAWTGA 321
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 547471031 324 VTGMALTLVMSFIFVGATDFFAGIYTNDPVAIKYAIIRMKHV 365
Cdd:cd13148 322 LMAAVLAGAIGLVLALFPELWLGLFTHDPAVLAAGASYLRIV 363
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
16-398 |
2.93e-17 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 83.39 E-value: 2.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 16 MFYKILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFV-GLSIGANVIIANFIGQGREDKV 94
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHL-GKLELAAASLASSFANVTGFSILlGLASALDTLCGQAFGAKNYKLV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 95 keAVHTVMSVALISGVSLLV-IGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYC 173
Cdd:cd13132 80 --GVYLQRALVILLLCCVPIsLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 174 LIISGIINILLNLLLVIVFHLSVAGVAIATVIAD-GVSAFLVVYFLSHSDDAIRLNIRELSLNKEiVVKVIKIGAPAG-- 250
Cdd:cd13132 158 SLVALLLNILLNYLLVFVLGLGFIGAALATSISYwLIVVLLLLYIFFSKGHKATWGGFSREAFRG-WGPFLKLAIPSAlm 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 251 --LQGVVFSLSnVFIQSAINgfGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGMA 328
Cdd:cd13132 237 lcLEWWAFEIL-VLLAGLLP--GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLV 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 329 LTLVMSFIFVGATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVIG 398
Cdd:cd13132 314 IGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVA 383
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
15-218 |
2.35e-14 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 74.67 E-value: 2.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 15 PMFYKILFFALPLAASSILQQLFNSADVAVVGRFAGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKV 94
Cdd:cd12082 216 ELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRA 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 95 KEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCL 174
Cdd:cd12082 296 RRITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVS 375
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 547471031 175 IISGIINILLNLLLVIVFHLSVAGVAIATVIADGVSAFLVVYFL 218
Cdd:cd12082 376 LLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLLLFF 419
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
19-385 |
1.69e-13 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 72.15 E-value: 1.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 19 KILFFALPLAASSILQQLFNSADVAVVGRfAGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKVKEAV 98
Cdd:PRK01766 13 QLLALALPILLAQVAQTAMGFVDTVMAGG-VSATDLAAVAIGTSIWLPVILFGHGLLLALTPIVAQLNGAGRRERIAHQV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 99 HTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNfgaaILRS----TGETRK----- 169
Cdd:PRK01766 92 RQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQ----VLRSfidgLGKTKPtmvig 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 170 --------PLYCLIISGIINILlnlllvivfHLSVAGVAIATVIADGVSAFLVVYFLSHSD--DAIRLNIRELSLNKEIV 239
Cdd:PRK01766 168 flglliniPLNYIFIYGKFGFP---------ELGGVGCGVATAIVYWVMFLAMLIYIKRARrfRDFRLFKGLYKPDWAVI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 240 VKVIKIGAPAGL----QGVVFSLSNVFIQSaingFGTHAMAGSSAGLNYEYFTyYMINAFNQTAVTFT-SQNYGAKDLER 314
Cdd:PRK01766 239 KRLLKLGLPIGLaiffEVSLFAVVTLLVSP----LGTVTVAAHQIALNFSSLL-FMLPLSLAMALTIRvGFELGAGRTLD 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 547471031 315 CKRAFRISLVTGMALTLVMSFIFVGATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGM 385
Cdd:PRK01766 314 ARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGY 384
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
16-217 |
1.97e-13 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 71.77 E-value: 1.97e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 16 MFYKILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVG-GNSpvINLLINM-FVGLSIGANVIIANFIGQGREDK 93
Cdd:cd13137 224 IIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASY-GTAALAAYQiGLR--IESLAFMpGFGFSMAASTLVGQNLGAGDPDE 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 94 VKEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFvMVYNFG-AAILRSTGETRKPLY 172
Cdd:cd13137 301 ARRYGKRALRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPF-LAISFVlSGALRGAGDTRPPLI 379
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 547471031 173 CLIISGIIN-ILLNLLLVIVFHLSVAGVAIATVIADGVSAFLVVYF 217
Cdd:cd13137 380 INLISMWLVrLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYR 425
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
248-399 |
3.66e-11 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 61.43 E-value: 3.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 248 PAGLQGVVFSLSNVFIQSAINGFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGM 327
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 547471031 328 ALTLVMSFIFVGATDFFAGIYTNDPVAIKYAIIRMKHVTLLECLTGVYEISGGALRGMGHSLLPALLTVIGS 399
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISL 152
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
3-207 |
7.56e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 63.68 E-value: 7.56e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 3 KIKKKQMDMIHGPMFYKILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVII 82
Cdd:cd13134 213 RFRLKDLRPFPKKLLKKILKIGLPSAGEELSYNLSQTVITAFIARL-GTAALAARTYASNISMFVFLFSLAIGQATQIIV 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 83 ANFIGQGREDKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILR 162
Cdd:cd13134 292 GHLVGAGDFDEAYKRVLKSLKIGLLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLR 371
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 547471031 163 STGETRKPLYCLIISG-IINILLNLLLVIVFHLSVAGVAIAtVIAD 207
Cdd:cd13134 372 AAGDARFPVLIGIISMwGISVPLAYLLGIVLGLGLLGVWIA-FAAD 416
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
19-218 |
2.11e-10 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 62.14 E-value: 2.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 19 KILFFALPLAASSILQQLFNSADVAVV----GRFAGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKV 94
Cdd:cd13143 223 KIIKEILALGFPSFLMQLSSSVVTIVLnltlLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRV 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 95 KEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYcL 174
Cdd:cd13143 303 KQALKLALIVALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAAL-L 381
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 547471031 175 IISGIINILLNLLLVIVFHLSVAGVAIATVIADGVSAFLVVYFL 218
Cdd:cd13143 382 SLLRQGLFLIPLLLILPRLFGLDGIWLAFPLAEILTLLLALILL 425
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
50-360 |
4.98e-10 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 61.29 E-value: 4.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 50 GSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLMI-- 127
Cdd:PRK10189 60 GKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVIMTLFAVLLAVLIHFFGEQIIDLVag 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 128 NTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYC--------LIISGIINILLNLLLVIVFhlsvAGV 199
Cdd:PRK10189 140 DATPEVKALALTYLELTVWSYPAAAITLIGSGALRGAGNTKIPLLInggmnilnIIISSILIYGLFSWQGLGF----VGA 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 200 AIATVIADGVSAFLVVYFLSHS-DDAIRLNIRE--LSLNKEIVVKVIKIGAPAGLQGVVFSLSNVFIQSAINGFGTHAMA 276
Cdd:PRK10189 216 GLGLTISRYIGAVAIIWVLMIGfNPALRISLKSyfKPLNFAIIWEVMGIGIPASIESVLFNGGKLLTQMFVAGMGTSVIA 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 277 GSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFR-ISLVTGMALTLV--MSFIFVGatdFFAGIYTNDPV 353
Cdd:PRK10189 296 GNFIAFSIAALINLPGNALGSASTIITGTRLGKGQIAQAERQLRhVFWLSTLGLTAIawLSAPFAG---LLASFYTQDPD 372
|
....*..
gi 547471031 354 AIKYAII 360
Cdd:PRK10189 373 VKHVVKI 379
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
23-362 |
1.57e-09 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 59.62 E-value: 1.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 23 FALPLAASSILQQLFNSADVAVVGRFAGSAALAAVGGNSPVINLL--INMFVGLSIGAnvIIANFIGQGREDKVKEAVHT 100
Cdd:PRK09575 17 YTIPSIAAMLVNGLYQIVDGIFIGHYVGAEGLAGINMAWPVIGIIlgIGLMVGMGTGS--LLSIKRGEGDLEKAKRILTT 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 101 VMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCLIISGII 180
Cdd:PRK09575 95 GLLLLLLLGPIVSVILFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDESPNLATGLMVIGALI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 181 NILLNLLLVIVFHLSVAGVAIATVIADGVSAFL-VVYFLShSDDAIRLNIRELSLNKEIVVKVIKIGAPAGLQ----GVV 255
Cdd:PRK09575 175 NIVLDYLFIGWLDWGLTGAAIATALAQLVVTVLgLGYFFS-SRANIRLTLKELRFNWSLAPKIVLLGSSSFFMylygSFV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 256 FSLSN-VFIQsaingFGTHAMAGSSAGLNYEYFTYYM----INAFNQTAVTFtsqNYGAKDLERCKR----AFRISLVTG 326
Cdd:PRK09575 254 VALHNrLFME-----YGSALTVGAYAIVGYLMVLYYLvaegIAEGMQPPVSY---YFGARQYDNIKKllklAMKVTVLAG 325
|
330 340 350
....*....|....*....|....*....|....*....
gi 547471031 327 MALTLVMSFIfvgaTDFFAGIYTN-DPVAIKYAI--IRM 362
Cdd:PRK09575 326 IAWVLLLNLF----PETMIALFNSgDSELIAETIvgIRL 360
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
12-219 |
9.11e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 57.15 E-value: 9.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 12 IHGPMFYKILFFALPlaasSILQQLFNSADVAV----VGRfAGSAALAAvggNSPVINLLINMF---VGLSIGANVIIAN 84
Cdd:cd13133 225 FDRELLRRILRLGLP----SGLQFFLDVGAFTVffllIGR-LGTTELAA---TNIVFSINSLAFlpmIGLGIAVSSLVGQ 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 85 FIGQGREDKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLMINT---PSEVINLAVLYLRI---YFLGMPFVMVYnfgA 158
Cdd:cd13133 297 ALGAGRPDLAMRVTRRGLKLALAYMLLLGILFLLFPELLLSIFTPgadFALIAELAVPLLRFvaaYILFDALALVF---A 373
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 547471031 159 AILRSTGETRKPLYCLIISGIINILLNLLLVIVFHLSVAGV-AIATVIADGVSAFLVVYFLS 219
Cdd:cd13133 374 GALRGAGDTRFVMLAELIVAWLYLLPPAYLLVVLGAGLAGAwTVETVYVIVLALIFLLRFRS 435
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
3-219 |
1.34e-08 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 56.40 E-value: 1.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 3 KIKKKQMDMIHGPMFYKILFFALPLAASSILQQLFNSADVAVVGRFAGSAALAAVGGNSPVINLLINMFVGLSIGANVII 82
Cdd:cd13128 191 KILLPKFFSFDLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRI 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 83 ANFIGQgREDKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSevINLAVLYLRIYFLGMPFVMVYNFGAAILR 162
Cdd:cd13128 271 SELYKN-DKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEE--YLPAALVLQILAWGFLFIFLNGIFGSILQ 347
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 547471031 163 STGETRKPLYCLIISGIINILLNLLLVIVFhlSVAGVAIATVIADGVSAFLVVYFLS 219
Cdd:cd13128 348 AIGKQKLTLKILLIGALLNVILNLLLIPKY--GIIGAAIATLISEFIIFILLLYLLK 402
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
19-222 |
8.89e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 54.12 E-value: 8.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 19 KILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKVKEAV 98
Cdd:cd13142 238 KIFRIGLPSSIEQSARALGFTVMTALVAGF-GTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIV 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 99 HTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCLIIS- 177
Cdd:cd13142 317 KKAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRl 396
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 547471031 178 GIINILLNLLLVIVFHLSVAGVAIATVIADGVSAFLVVYFLSHSD 222
Cdd:cd13142 397 WVIRIPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGT 441
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
20-215 |
1.25e-07 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 53.41 E-value: 1.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 20 ILFFALPLAASSILQQLFNSADVAVVGRFAGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKVKEAVH 99
Cdd:COG2244 175 VLKYSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYR 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 100 TVMSVALISGVSLLVIGIIIAKPILLMINTPSEVInlAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCLIISGI 179
Cdd:COG2244 255 KALRLLLLLGLPLALGLALLAPPLLSLLFGPEYAE--AAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAV 332
|
170 180 190
....*....|....*....|....*....|....*.
gi 547471031 180 INILLNLLLVIVFhlSVAGVAIATVIADGVSAFLVV 215
Cdd:COG2244 333 LNLVLNLLLIPRY--GLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
14-221 |
2.06e-07 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 52.86 E-value: 2.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 14 GPMFYKILFFALPLAASSILQQLFNSADVAVVGR------FAGSAALAAVGGNSPVINLLIN--MFVGLSIGANVI--IA 83
Cdd:cd13124 220 KEILKELLSYAIPITLSSLILPLLQLIDSFTVPRrlqaagLSESEATALYGILTGRAQPLVQlpTVIATALSTSLVpaIS 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 84 NFIGQGREDKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEvinlAVLYLRIYFLGMPFVMVYNFGAAILRS 163
Cdd:cd13124 300 EAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSE----GGLILQILAPSILFLSLQQVTAAILQG 375
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 547471031 164 TGETRKPLYCLIISGIINILLNLLLVIVFHlsVAGVAIATVIADGVSAFLVVYFLSHS 221
Cdd:cd13124 376 LGKVKIPVINLLIGLLVKIVLNYVLIPIFG--IYGAAIATVIGFLVAALLNLRALKKL 431
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
65-338 |
1.74e-06 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 50.15 E-value: 1.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 65 NLLINMFVGLSIGANVI--IANFIGQGREDKVKEAVHTVMSVALISGVSLLVIGIIIAKPI--LLMINTPSEVINLAVLY 140
Cdd:COG0728 46 NLLRRLFAEGALSAAFVpvLAEALEKEGEEEARRFASRVLTLLLLVLLVLTLLGILFAPLLvkLLAPGFDPEKFALAVAL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 141 LRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCLIISGIINILLNLLLVIVFHLSVAGVAIATVIADGVSAFLVVYFLSH 220
Cdd:COG0728 126 TRIMFPYILFIGLSALLGGVLNARGRFAAPALAPVLLNLVIIAGLLLLAPLFGPGIYALAWGVLLGGVLQLLIQLPALRR 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 221 SDDAIRLNireLSLNKEIVVKVIKIGAPAGLqGVVFSLSNVFIQSAingFGTHAMAGSSAGLNYEYFTYYM-----INAF 295
Cdd:COG0728 206 LGLRLRPR---FDLRDPGVRRVLKLMLPALL-GVSVSQINLLVDTI---LASFLPEGSVSALYYADRLYQLplglfGVAI 278
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 547471031 296 NQTAVTFTSQNYGAKDLERCKRAFRISLVTGMALTLVMSFIFV 338
Cdd:COG0728 279 GTALLPRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLI 321
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
4-143 |
3.69e-06 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 48.78 E-value: 3.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 4 IKKKQMDMIHGPMFYKILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIA 83
Cdd:TIGR00797 202 LKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALLALLVARL-GSIALAAHQIALNVESLLFMPAFGFGIAVSILVG 280
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 84 NFIGQGREDKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRI 143
Cdd:TIGR00797 281 QALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREFIARLFTNDPEVLELAAIYLIF 340
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
65-338 |
8.00e-06 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 47.83 E-value: 8.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 65 NLLINMFVGLSIGANVI--IANFIGQGREDKVKEAVHTVMSVALISGVSLLVIGIIIAKPI--LLMINTPSEVINLAVLY 140
Cdd:cd13123 39 NLLRRLFAEGALSAAFVpvFSEYLEKEGEEEARRFASRVLTLLLLVLLLLTLLGILFAPLLvkLLAPGFSGDKFELAVAL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 141 LRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCLIISGIINILLNLLLVIVFHLSVAGVAIATVIAdGVSAFLVVYFlsh 220
Cdd:cd13123 119 TRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLVIIAGLLLLAPLFDLGIYALAWGVLLG-GVLQLLVQLP--- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 221 sdDAIRLNIR---ELSLNKEIVVKVIKIGAPAGLqGVVFSLSNVFIQSAingFGTHAMAGSSAGLNYEYFTYYMI----- 292
Cdd:cd13123 195 --ALRRLGFRfrpRLDFRDPGVRRVLKLMLPALL-GVSVSQINLLVDTI---LASFLPEGSISALYYADRLYQLPlgifg 268
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 547471031 293 NAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGMALTLVMSFIFV 338
Cdd:cd13123 269 VAIATALLPRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLI 314
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
17-220 |
1.27e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 47.09 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 17 FYKILFFALPLAASSILQQLFNSADVAVVGRFAGSAALA----AVGGNSPVINLLINMF--VGLSIGANViianfigQGR 90
Cdd:cd13127 198 LKELLSFGSKLLGSNLLNYFSRNLDNLIIGKFLGAAALGyysrAYRLALLPVQNITGPItrVLFPALSRL-------QDD 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 91 EDKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVinLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKP 170
Cdd:cd13127 271 PERLRRAYLKALRLLALITFPLMVGLALLAEPLVLLLLGEKWL--PAVPILQILALAGLFQPLSSLNGSLLLALGRTDLL 348
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 547471031 171 LYcliISGIINILLNLLLVIVFHLSVAGVAIATVIADGVSAFLVVYFLSH 220
Cdd:cd13127 349 LK---LGLIKAVLTVLALLIGIPYGIIGVAIAYVIASLLSFPLNLYLAGR 395
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
3-177 |
3.01e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 45.98 E-value: 3.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 3 KIKKKQMDMIHGPMFYKILFFALPLAASSILQQLFNsadvAVVGRFA---GSAALAAVGGNSPVINLLINMFVGLSIGAN 79
Cdd:cd13140 216 FLKIRILKRPDRKYIKEILKLGLPVALQSILFALIS----MILARIIasfGPVAIAAQKVGSQIESISWMTAEGFSTALA 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 80 VIIANFIGQGREDKVKEAVHTVMSVALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAA 159
Cdd:cd13140 292 AFVGQNYGAGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTG 371
|
170
....*....|....*...
gi 547471031 160 ILRSTGETRkplYCLIIS 177
Cdd:cd13140 372 AFNGLGRTK---PPAIIS 386
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
17-205 |
3.51e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 42.66 E-value: 3.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 17 FYKILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGR-EDKVK 95
Cdd:cd13135 227 YKFTIKLGLPLGGEEFLWNIGNLAVIRILNRI-GELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDlKEALR 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 96 EAVHTVMSVALISGVSLLVIgIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCLI 175
Cdd:cd13135 306 IGNICLGLGLLIYIAAAIVF-LAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQI 384
|
170 180 190
....*....|....*....|....*....|
gi 547471031 176 ISGIINILLNLLLVIVFHLSVAGVAIATVI 205
Cdd:cd13135 385 IGTIIVVSVALLLIFVFKLGLAGVYITLFI 414
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
20-385 |
4.69e-04 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 42.42 E-value: 4.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 20 ILFFALPLAASSILQQLFNSADVAVVGRFaGSAALAAVGGNSPVINLLINMFVGLSIGANVIIAnfIGQGREDKvkEAVH 99
Cdd:PRK00187 12 ILRLAGPLIASQLAHMLMVFTDTLMMGRL-GPEALAGGGLGAASYSFVSIFCVGVIAAVGTLVA--IRHGAGDI--EGAT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 100 TVMSVALISGVSLLVIGIII---AKPILLMINTPSEVINLAVLYLRIYFLGMP----FVMVYNFGAAILRSTgetrkPLY 172
Cdd:PRK00187 87 RLAQAGLWLAWLLALVAALLlwnLKPLLLLFGQAPQNVDAAMQFLHLLPFALPgylsFMALRGFTSALGRAG-----PVM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 173 CLIISGIINILLNLLLVIVF-----HLSVAGVAIAT-VIADGVSAFLVVYFLSHSD-DAIRLNIRELSLNKEIVVKVIKI 245
Cdd:PRK00187 162 VISLAGAVANLLLNYALIEGwfglpKLGLMGIGLVTaLVSNGMALALALYIRRHPAyAAYPLRKGLSRPSRAALRELWRL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 246 GAPAGLQGVVFSLSNVFIQSAINGFGTHAMAGSSAGLNYEYfTYYMINAFNQTAVTF-TSQNYGAKDLERCKRAFRISLV 324
Cdd:PRK00187 242 GLPIGGTYAVEVGLFTFAALCMGALGSTQLAAHQIALQIVS-VAFMVPVGLSYAVTMrVGQHYGAGRLLEARRAGRVGIG 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 547471031 325 TGMALTLVMSFIFVGATDFFAGIYT--NDPVaikYAIIRMKHVTLL------ECLTGVYEISGGALRGM 385
Cdd:PRK00187 321 FGAVVMLLFAGLFWLLPEAIIGLFLdrNDPA---FAEIVQLAVSLLavaawfELFDGTQTIAMGAIRGL 386
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
24-338 |
1.48e-03 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 40.88 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 24 ALPLAASSILQQLFNSADVAVVGRFAGSAALAAVGGNSPVINLLINMFVGLSIGANVIIANFIGQGREDKVKEAVHTVMS 103
Cdd:PRK10367 15 ALPMIFSNITVPLLGLVDTAVIGHLDSPVYLGGVAVGATATSFLFMLLLFLRMSTTGLTAQAFGAKNPQALARALVQPLL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 104 VALISGVSLLVIGIIIAKPILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNFGAAILRSTGETRKPLYCLIISGIINIL 183
Cdd:PRK10367 95 LALGAGALIALLRTPLIDLALHIVGGSEAVLEQARRFLEIRWLSAPASLANLVLLGWLLGVQYARAPVILLVVGNILNIV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 184 LNLLLVIVFHLSVAGVAIATVIADGVSAFLVVYF-----------LSHSDDAIRLNIREL-SLNKEIVVKVIkigapagL 251
Cdd:PRK10367 175 LDLWLVMGLHMNVQGAALATVIAEYATLLIGLLMvrkvlklrgisLEMLKTAWRGNFRRLlALNRDIMLRSL-------L 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 252 QGVVFSLSNVFIQSaingFGTHAMAGSSAGLNYEYFTYYMINAFNQTAVTFTSQNYGAKDLERCKRAFRISLVTGMALTL 331
Cdd:PRK10367 248 LQLCFGAITVLGAR----LGSDIIAVNAVLMTLLTFTAYALDGFAYAVEAHSGQAYGARDGSQLLDVWRAACRQSGIVAL 323
|
....*..
gi 547471031 332 VMSFIFV 338
Cdd:PRK10367 324 LFSLVYA 330
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
77-258 |
1.75e-03 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 40.60 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 77 GANVIIANFIGQGREDKVKEAVHTVMSVALISGVSLLVIgiiiakpILLMINTPSEVINLAVLYLRIYFLGMPFVMVYNF 156
Cdd:cd13128 55 GLPTALVREIARYRKEKIREIISTSLVLKLILGILALLL-------LFLFAFLIAFYDPELVLLLYILALSLPFSALNSL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547471031 157 GAAILRSTGETRKPLYCLIIsGIINILLNLLLVIVFHLSVAGVAIATVIADGVSAFLVVYFLSHSddaiRLNIRELSLNK 236
Cdd:cd13128 128 FRGIFQGFEKMKYIVIARII-ESVLSLILALILVLLGGGLIGFALAYLIASVLSAILLLYIYRKK----ILLPKFFSFDL 202
|
170 180
....*....|....*....|..
gi 547471031 237 EIVVKVIKIGAPAGLQGVVFSL 258
Cdd:cd13128 203 KLAKELLRFSIPLALSGIFSLI 224
|
|
| |
