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Conserved domains on  [gi|549799551|ref|WP_022562980|]
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glycosyltransferase family 4 protein [Agrobacterium pusense]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133453)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
SCOP:  3001586

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
5-378 2.69e-54

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 183.12  E-value: 2.69e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551   5 LFVSHTGE--KGGAELFLADIVKA-GPRSWRACFLSGGGAADDLAECGRPPlllsagekmlsIRRDSSFGAMLRGALDVL 81
Cdd:cd03801    3 LLLSPELPppVGGAERHVRELARAlAARGHDVTVLTPADPGEPPEELEDGV-----------IVPLLPSLAALLRARRLL 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  82 AvAWQLSRQAKNHDVICANSQKALFVCALAAKLSRRPLIWILHDIVTDPAFSAANR-----RASLTFSRLFARLVAVnSQ 156
Cdd:cd03801   72 R-ELRPLLRLRKFDVVHAHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAerrllARAEALLRRADAVIAV-SE 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 157 ETGRAFVKAGG-EEDKVRIVYNGFDPakasvyDPARAQQLRRELGLGPQPLIGLFGRLSEWKGQHVFLEAIAAM----EG 231
Cdd:cd03801  150 ALRDELRALGGiPPEKIVVIPNGVDL------ERFSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLlrrgPD 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 232 VQAVIVGSAlfgqEAYEARIRTLasSLGLDSRVRFLGFRP--DVTELMAAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVA 309
Cdd:cd03801  224 VRLVIVGGD----GPLRAELEEL--ELGLGDRVRFLGFVPdeELPALYAAADVFVLPSR-YEGFGLVVLEAMAAGLPVVA 296
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 549799551 310 TRGGGVTEIIRDGETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDVMWRFSLEETCRTISALL 378
Cdd:cd03801  297 TDVGGLPEVVEDGEGGLVVPPDDVEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
5-378 2.69e-54

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 183.12  E-value: 2.69e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551   5 LFVSHTGE--KGGAELFLADIVKA-GPRSWRACFLSGGGAADDLAECGRPPlllsagekmlsIRRDSSFGAMLRGALDVL 81
Cdd:cd03801    3 LLLSPELPppVGGAERHVRELARAlAARGHDVTVLTPADPGEPPEELEDGV-----------IVPLLPSLAALLRARRLL 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  82 AvAWQLSRQAKNHDVICANSQKALFVCALAAKLSRRPLIWILHDIVTDPAFSAANR-----RASLTFSRLFARLVAVnSQ 156
Cdd:cd03801   72 R-ELRPLLRLRKFDVVHAHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAerrllARAEALLRRADAVIAV-SE 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 157 ETGRAFVKAGG-EEDKVRIVYNGFDPakasvyDPARAQQLRRELGLGPQPLIGLFGRLSEWKGQHVFLEAIAAM----EG 231
Cdd:cd03801  150 ALRDELRALGGiPPEKIVVIPNGVDL------ERFSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLlrrgPD 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 232 VQAVIVGSAlfgqEAYEARIRTLasSLGLDSRVRFLGFRP--DVTELMAAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVA 309
Cdd:cd03801  224 VRLVIVGGD----GPLRAELEEL--ELGLGDRVRFLGFVPdeELPALYAAADVFVLPSR-YEGFGLVVLEAMAAGLPVVA 296
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 549799551 310 TRGGGVTEIIRDGETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDVMWRFSLEETCRTISALL 378
Cdd:cd03801  297 TDVGGLPEVVEDGEGGLVVPPDDVEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
204-360 7.80e-31

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 115.06  E-value: 7.80e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  204 QPLIGLFGRLSEWKGQHVFLEAIA----AMEGVQAVIVGsalfgQEAYEARIRTLASSLGLDSRVRFLGF--RPDVTELM 277
Cdd:pfam00534   2 KKIILFVGRLEPEKGLDLLIKAFAllkeKNPNLKLVIAG-----DGEEEKRLKKLAEKLGLGDNVIFLGFvsDEDLPELL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  278 AAMDAVAHTSVVaEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGETGLLVPPADAPALAAALGRILTDPTLAEKLGKKG 357
Cdd:pfam00534  77 KIADVFVLPSRY-EGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPNNAEALAEAIDKLLEDEELRERLGENA 155

                  ...
gi 549799551  358 RED 360
Cdd:pfam00534 156 RKR 158
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
171-377 4.22e-24

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 102.11  E-value: 4.22e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  171 KVRIVYNGFDPAKASVYDPARAQQLRRELGLGPQPLIGLFGRLSEWKGQHVFLEAIAAM--------EGVQAVIVGSAlf 242
Cdd:TIGR03088 161 KIHQIYNGVDTERFHPSRGDRSPILPPDFFADESVVVGTVGRLQAVKDQPTLVRAFALLvrqlpegaERLRLVIVGDG-- 238
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  243 gqeAYEARIRTLASSLGLDSRVRFLGFRPDVTELMAAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDG 322
Cdd:TIGR03088 239 ---PARGACEQMVRAAGLAHLVWLPGERDDVPALMQALDLFVLPSL-AEGISNTILEAMASGLPVIATAVGGNPELVQHG 314
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 549799551  323 ETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDVMWRFSLEETCRTISAL 377
Cdd:TIGR03088 315 VTGALVPPGDAVALARALQPYVSDPAARRAHGAAGRARAEQQFSINAMVAAYAGL 369
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
276-381 6.73e-22

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 90.05  E-value: 6.73e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 276 LMAAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGETGLLVPPADAPALAAALGRILTDPTLAEKLGK 355
Cdd:COG0438   17 LLAAADVFVLPSR-SEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAILRLLEDPELRRRLGE 95
                         90       100
                 ....*....|....*....|....*.
gi 549799551 356 KGREDVMWRFSLEETCRTISALLSEV 381
Cdd:COG0438   96 AARERAEERFSWEAIAERLLALYEEL 121
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
172-368 2.11e-16

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 79.83  E-value: 2.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 172 VRIVYNGFDPakaSVYDPARAQQLRRELGLGPQPLIGLF-GRLSEWKGQHVFLEA----IAAMEGVQAVIVG----SALF 242
Cdd:PRK15484 163 ISIVPNGFCL---ETYQSNPQPNLRQQLNISPDETVLLYaGRISPDKGILLLMQAfeklATAHSNLKLVVVGdptaSSKG 239
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 243 GQEAYEARIRTLASSLGldSRVRFLGFRP--DVTELMAAMDAVAHTSVVAEPFGRVVVEAMMCGRPVVATRGGGVTEIIR 320
Cdd:PRK15484 240 EKAAYQKKVLEAAKRIG--DRCIMLGGQPpeKMHNYYPLADLVVVPSQVEEAFCMVAVEAMAAGKPVLASTKGGITEFVL 317
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 549799551 321 DGETGL-LVPPADAPALAAALGRILTDPTLAEkLGKKGREDVMWRFSLE 368
Cdd:PRK15484 318 EGITGYhLAEPMTSDSIISDINRTLADPELTQ-IAEQAKDFVFSKYSWE 365
PelF NF038011
GT4 family glycosyltransferase PelF; Proteins of this family are components of the ...
163-319 1.48e-13

GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter.


Pssm-ID: 411604 [Multi-domain]  Cd Length: 489  Bit Score: 71.89  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 163 VKAGGEEDKVRIVYNGFDPAKasvYDPARAQqlRRElglGPQPLIGLFGRLSEWKGQHVFLEAI----AAMEGVQAVIVG 238
Cdd:NF038011 273 IADGAPPERTRVIPNGIDLPR---LAPLRAQ--RPA---GIPPVVGLIGRVVPIKDIKTFIRAMrtvvRAMPEAEGWIVG 344
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 239 SAlfgQE--AYEARIRTLASSLGLDSRVRFLGFRpDVTELMAAMDAVAHTSVV-AEPFgrVVVEAMMCGRPVVATRGGGV 315
Cdd:NF038011 345 PE---EEdpAYAAECRSLVASLGLQDKVKFLGFQ-KIDDLLPQVGLMVLSSISeALPL--VVLEAFAAGVPVVTTDVGSC 418

                 ....
gi 549799551 316 TEII 319
Cdd:NF038011 419 RQLI 422
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
5-378 2.69e-54

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 183.12  E-value: 2.69e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551   5 LFVSHTGE--KGGAELFLADIVKA-GPRSWRACFLSGGGAADDLAECGRPPlllsagekmlsIRRDSSFGAMLRGALDVL 81
Cdd:cd03801    3 LLLSPELPppVGGAERHVRELARAlAARGHDVTVLTPADPGEPPEELEDGV-----------IVPLLPSLAALLRARRLL 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  82 AvAWQLSRQAKNHDVICANSQKALFVCALAAKLSRRPLIWILHDIVTDPAFSAANR-----RASLTFSRLFARLVAVnSQ 156
Cdd:cd03801   72 R-ELRPLLRLRKFDVVHAHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAerrllARAEALLRRADAVIAV-SE 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 157 ETGRAFVKAGG-EEDKVRIVYNGFDPakasvyDPARAQQLRRELGLGPQPLIGLFGRLSEWKGQHVFLEAIAAM----EG 231
Cdd:cd03801  150 ALRDELRALGGiPPEKIVVIPNGVDL------ERFSPPLRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLlrrgPD 223
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 232 VQAVIVGSAlfgqEAYEARIRTLasSLGLDSRVRFLGFRP--DVTELMAAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVA 309
Cdd:cd03801  224 VRLVIVGGD----GPLRAELEEL--ELGLGDRVRFLGFVPdeELPALYAAADVFVLPSR-YEGFGLVVLEAMAAGLPVVA 296
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 549799551 310 TRGGGVTEIIRDGETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDVMWRFSLEETCRTISALL 378
Cdd:cd03801  297 TDVGGLPEVVEDGEGGLVVPPDDVEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
5-353 5.35e-43

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 152.90  E-value: 5.35e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551   5 LFVSHTGEKGGAELFLADIVKAgprswracFLSGGGAADDLAECGRPPLLLSAGEKMLSIRRDSSFGAMLRGALdvLAVA 84
Cdd:cd03811    3 LFVIPSLSGGGAERVLLNLANA--------LDKRGYDVTLVLLRDEGDLDKQLNGDVKLIRLLIRVLKLIKLGL--LKAI 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  85 WQLSRQAKNH--DVICANSQKALFVcALAAKLSRRPLIWILHDIVTDPAFSAANRRASLTFSRLFARLVAVnSQETGRAF 162
Cdd:cd03811   73 LKLKRILKRAkpDVVISFLGFATYI-VAKLAAARSKVIAWIHSSLSKLYYLKKKLLLKLKLYKKADKIVCV-SKGIKEDL 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 163 VKAGGE-EDKVRIVYNGFDPAkasvydpaRAQQLRRELGLGPQ---PLIGLFGRLSEWKGQHVFLEAIA----AMEGVQA 234
Cdd:cd03811  151 IRLGPSpPEKIEVIYNPIDID--------RIRALAKEPILNEPedgPVILAVGRLDPQKGHDLLIEAFAklrkKYPDVKL 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 235 VIVGSalfGQEayEARIRTLASSLGLDSRVRFLGFRPDVTELMAAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVATRGGG 314
Cdd:cd03811  223 VILGD---GPL--REELEKLAKELGLAERVIFLGFQSNPYPYLKKADLFVLSSR-YEGFPNVLLEAMALGTPVVSTDCPG 296
                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 549799551 315 VTEIIRDGETGLLVPPADAPALAAALGRILTDPTLAEKL 353
Cdd:cd03811  297 PREILDDGENGLLVPDGDAAALAGILAALLQKKLDAALR 335
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
35-364 2.08e-41

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 148.66  E-value: 2.08e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  35 FLSGGGA-------ADDLAECGRPPLLLSAGEKML------SIRRDSSFGAMLRGALDVLAVAWQLSRqaKNHDVICANS 101
Cdd:cd03819    7 ALEIGGAetyildlARALAERGHRVLVVTAGGPLLprlrqiGIGLPGLKVPLLRALLGNVRLARLIRR--ERIDLIHAHS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 102 QKALFVCALAAKLSRRPLIWILHDIVTDPAFSAANRRASLTFSRlfaRLVAVNSQETGRAFVKAGGEEDKVRIVYNGFDP 181
Cdd:cd03819   85 RAPAWLGWLASRLTGVPLVTTVHGSYLATYHPKDFALAVRARGD---RVIAVSELVRDHLIEALGVDPERIRVIPNGVDT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 182 AKasvYDPARAQQLRRELGL-GPQPLIGLFGRLSEWKGQHVFLEAIA---AMEGVQAVIVGSAlfgqeAYEARIRTLASS 257
Cdd:cd03819  162 DR---FPPEAEAEERAQLGLpEGKPVVGYVGRLSPEKGWLLLVDAAAelkDEPDFRLLVAGDG-----PERDEIRRLVER 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 258 LGLDSRVRFLGFRPDVTELMAAMDAVAHTSVVaEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGETGLLVPPADAPALA 337
Cdd:cd03819  234 LGLRDRVTFTGFREDVPAALAASDVVVLPSLH-EEFGRVALEAMACGTPVVATDVGGAREIVVHGRTGLLVPPGDAEALA 312
                        330       340
                 ....*....|....*....|....*..
gi 549799551 338 AALGRILTDPTLAEKLGKKGREDVMWR 364
Cdd:cd03819  313 DAIRAAKLLPEAREKLQAAAALTEAVR 339
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
104-381 2.67e-37

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 138.28  E-value: 2.67e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 104 ALFVCALAAKLSRRPLIWILH--DIV---TDPAFSAANRRASltfsRLFARLVAVnSQETGRAFVKAGGEEDKVRIVYNG 178
Cdd:cd03798  107 AGFAAALLARLYGVPYVVTEHgsDINvfpPRSLLRKLLRWAL----RRAARVIAV-SKALAEELVALGVPRDRVDVIPNG 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 179 fdpakasvYDPARAQQLRRELGLGP-QPLIGLFGRLSEWKGQHVFLEAIA----AMEGVQAVIVGSalfGQEayEARIRT 253
Cdd:cd03798  182 --------VDPARFQPEDRGLGLPLdAFVILFVGRLIPRKGIDLLLEAFArlakARPDVVLLIVGD---GPL--REALRA 248
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 254 LASSLGLDSRVRFLGFRP--DVTELMAAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGETGLLVPPA 331
Cdd:cd03798  249 LAEDLGLGDRVTFTGRLPheQVPAYYRACDVFVLPSR-HEGFGLVLLEAMACGLPVVATDVGGIPEVVGDPETGLLVPPG 327
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 549799551 332 DAPALAAALGRILTDPTLAEkLGKKGREDVMWRFSLEETCRTISALLSEV 381
Cdd:cd03798  328 DADALAAALRRALAEPYLRE-LGEAARARVAERFSWVKAADRIAAAYRDV 376
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
14-378 5.12e-34

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 129.36  E-value: 5.12e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  14 GGAELFLADIVKAGPRSWRAC---FLSGGGA-ADDLAECGRPPLLLSAGEKMlsirrdsSFGAMLRgaldvlavawqLSR 89
Cdd:cd03807   12 GGAETMLLRLLEHMDKSRFEHvviSLTGDGVlGEELLAAGVPVVCLGLSSGK-------DPGVLLR-----------LAK 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  90 QAK--NHDVICANSQKALFVCALAAKLSR-RPLIWILHDIVTDPAFSAANRRASLTFSRLFARLVAvNSQETGRAFVKAG 166
Cdd:cd03807   74 LIRkrNPDVVHTWMYHADLIGGLAAKLAGgVKVIWSVRSSNIPQRLTRLVRKLCLLLSKFSPATVA-NSSAVAEFHQEQG 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 167 GEEDKVRIVYNGFDPAKaSVYDPARAQQLRRELGLGPQ-PLIGLFGRLSEWKGQHVFLEAIA--AMEGVQAVIVgsaLFG 243
Cdd:cd03807  153 YAKNKIVVIYNGIDLFK-LSPDDASRARARRRLGLAEDrRVIGIVGRLHPVKDHSDLLRAAAllVETHPDLRLL---LVG 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 244 QEAYEARIRTLASSLGLDSRVRFLGFRPDVTELMAAMDAVAHTSVVaEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGe 323
Cdd:cd03807  229 RGPERPNLERLLLELGLEDRVHLLGERSDVPALLPAMDIFVLSSRT-EGFPNALLEAMACGLPVVATDVGGAAELVDDG- 306
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 549799551 324 TGLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDVMWRFSLEETCRTISALL 378
Cdd:cd03807  307 TGFLVPAGDPQALADAIRALLEDPEKRARLGRAARERIANEFSIDAMVRRYETLY 361
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
166-376 3.17e-32

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 125.05  E-value: 3.17e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 166 GGEEDKVRIVYNGFDPAKASVYDPARAQqlRRELGLGPQPLIGLF-GRLSEWKGQHVFLEAIAAM----EGVQAVIVGSA 240
Cdd:cd03800  183 GADPSRINVVPPGVDLERFFPVDRAEAR--RARLLLPPDKPVVLAlGRLDPRKGIDTLVRAFAQLpelrELANLVLVGGP 260
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 241 LFGQEAYEA-RIRTLASSLGLDSRVRFLGF--RPDVTELMAAMDAVAHTSVVaEPFGRVVVEAMMCGRPVVATRGGGVTE 317
Cdd:cd03800  261 SDDPLSMDReELAELAEELGLIDRVRFPGRvsRDDLPELYRAADVFVVPSLY-EPFGLTAIEAMACGTPVVATAVGGLQD 339
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 549799551 318 IIRDGETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDVMWRFSLEETCRTISA 376
Cdd:cd03800  340 IVRDGRTGLLVDPHDPEALAAALRRLLDDPALWQRLSRAGLERARAHYTWESVADQLLT 398
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
204-360 7.80e-31

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 115.06  E-value: 7.80e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  204 QPLIGLFGRLSEWKGQHVFLEAIA----AMEGVQAVIVGsalfgQEAYEARIRTLASSLGLDSRVRFLGF--RPDVTELM 277
Cdd:pfam00534   2 KKIILFVGRLEPEKGLDLLIKAFAllkeKNPNLKLVIAG-----DGEEEKRLKKLAEKLGLGDNVIFLGFvsDEDLPELL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  278 AAMDAVAHTSVVaEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGETGLLVPPADAPALAAALGRILTDPTLAEKLGKKG 357
Cdd:pfam00534  77 KIADVFVLPSRY-EGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPNNAEALAEAIDKLLEDEELRERLGENA 155

                  ...
gi 549799551  358 RED 360
Cdd:pfam00534 156 RKR 158
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
166-368 1.80e-29

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 118.59  E-value: 1.80e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 166 GGEEDKVRIVYNGFDPAKasvYDPARAQQLRRElglgpQPLIGLFGRLSEWKGQHVFLEAIA----AMEGVQAVIVGsAL 241
Cdd:cd03813  263 GADPDKTRVIPNGIDIQR---FAPAREERPEKE-----PPVVGLVGRVVPIKDVKTFIRAFKlvrrAMPDAEGWLIG-PE 333
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 242 FGQEAYEARIRTLASSLGLDSRVRFLGFrPDVTELMAAMDAVAHTSVVaEPFGRVVVEAMMCGRPVVATRGGGVTEIIRD 321
Cdd:cd03813  334 DEDPEYAQECKRLVASLGLENKVKFLGF-QNIKEYYPKLGLLVLTSIS-EGQPLVILEAMASGVPVVATDVGSCRELIYG 411
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 549799551 322 -----GETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDVMWRFSLE 368
Cdd:cd03813  412 addalGQAGLVVPPADPEALAEALIKLLRDPELRQAFGEAGRKRVEKYYTLE 463
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
167-359 7.66e-29

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 115.45  E-value: 7.66e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 167 GEEDKVRIVYNGFDPAKASVYDPARaqqLRRELGLGP-QPLIGLFGRLSEWKGQHVFLEAIA---AMEGVQAVIVGSAlf 242
Cdd:cd03817  166 GVKGPIEVIPNGIDLDKFEKPLNTE---ERRKLGLPPdEPILLYVGRLAKEKNIDFLLRAFAelkKEPNIKLVIVGDG-- 240
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 243 gqeAYEARIRTLASSLGLDSRVRFLGFRPD--VTELMAAMDAVAHTSVVaEPFGRVVVEAMMCGRPVVATRGGGVTEIIR 320
Cdd:cd03817  241 ---PEREELKELARELGLADKVIFTGFVPReeLPEYYKAADLFVFASTT-ETQGLVYLEAMAAGLPVVAAKDPAASELVE 316
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 549799551 321 DGETGLLVPPADAPALAAALgRILTDPTLAEKLGKKGRE 359
Cdd:cd03817  317 DGENGFLFEPNDETLAEKLL-HLRENLELLRKLSKNAEI 354
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
5-353 1.97e-28

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 113.96  E-value: 1.97e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551   5 LFVSH---TGEKGGAELFLADIVKA-GPRSWRACFLS---GGGAADDLAECGRPPLLLSAGEKMLSIRRDSSFGAMLR-- 75
Cdd:cd03823    3 LLVNSlypPQRVGGAEISVHDLAEAlVAEGHEVAVLTagvGPPGQATVARSVVRYRRAPDETLPLALKRRGYELFETYnp 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  76 GALDVLAVAWQLSRQaknhDVICANSQKALFVCAL-AAKLSRRPLIWILHDI-VTDPafsaanrRASLTFSRlfARLVAV 153
Cdd:cd03823   83 GLRRLLARLLEDFRP----DVVHTHNLSGLGASLLdAARDLGIPVVHTLHDYwLLCP-------RQFLFKKG--GDAVLA 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 154 NSQETGRAFVKAGGEEDKVRIVYNGFDPakasvyDPARAQQLRRelglGPQPL-IGLFGRLSEWKGQHVFLEAI--AAME 230
Cdd:cd03823  150 PSRFTANLHEANGLFSARISVIPNAVEP------DLAPPPRRRP----GTERLrFGYIGRLTEEKGIDLLVEAFkrLPRE 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 231 GVQAVIVGSALFGQEAyearirtlasSLGLDSRVRFLGFRP--DVTELMAAMDAVAHTSVVAEPFGRVVVEAMMCGRPVV 308
Cdd:cd03823  220 DIELVIAGHGPLSDER----------QIEGGRRIAFLGRVPtdDIKDFYEKIDVLVVPSIWPEPFGLVVREAIAAGLPVI 289
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 549799551 309 ATRGGGVTEIIRDGETGLLVPPADAPALAAALGRILTDPTLAEKL 353
Cdd:cd03823  290 ASDLGGIAELIQPGVNGLLFAPGDAEDLAAAMRRLLTDPALLERL 334
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
205-328 1.55e-27

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 105.67  E-value: 1.55e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  205 PLIGLFGRLSEW-KGQHVFLEAIAAM----EGVQAVIVGSAlfGQEAYEARIRtlasslGLDSRVRFLGFRPDVTELMAA 279
Cdd:pfam13692   2 PVILFVGRLHPNvKGVDYLLEAVPLLrkrdNDVRLVIVGDG--PEEELEELAA------GLEDRVIFTGFVEDLAELLAA 73
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 549799551  280 MDAVAHTSVvAEPFGRVVVEAMMCGRPVVATRGGGVTEIIrDGETGLLV 328
Cdd:pfam13692  74 ADVFVLPSL-YEGFGLKLLEAMAAGLPVVATDVGGIPELV-DGENGLLV 120
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
95-375 6.14e-27

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 109.61  E-value: 6.14e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  95 DVICANSQKALFVCALAAKLSRRPLIwiLHdIVTDPAF-SAANRRASLTFSRL------FARLVAVNSQETGRAFVKAGG 167
Cdd:cd03808   83 DIVHCHTPKPGILGRLAARLAGVPKV--IY-TVHGLGFvFTEGKLLRLLYLLLeklallFTDKVIFVNEDDRDLAIKKGI 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 168 --EEDKVRIVYNGFDPakaSVYDParaqqlRRELGLGPQPLIGLFGRLSEWKGQHVFLEAIAAM----EGVQAVIVGsal 241
Cdd:cd03808  160 ikKKKTVLIPGSGVDL---DRFQY------SPESLPSEKVVFLFVARLLKDKGIDELIEAAKILkkkgPNVRFLLVG--- 227
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 242 FGQEAYEARIrtLASSLGLDSRVRFLGFRPDVTELMAAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVATRGGGVTEIIRD 321
Cdd:cd03808  228 DGELENPSEI--LIEKLGLEGRIEFLGFRSDVPELLAESDVFVLPSY-REGLPRSLLEAMAAGRPVITTDVPGCRELVID 304
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 549799551 322 GETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDVMWRFSLEETCRTIS 375
Cdd:cd03808  305 GVNGFLVPPGDVEALADAIEKLIEDPELRKEMGEAARKRVEEKFDEEKVVNKLL 358
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
109-367 1.50e-24

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 103.30  E-value: 1.50e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 109 ALAAKLSRR---PLIWILH--DIVTDPAFSAANRRASLTFSRLFARL-------VAVnSQETGRAFVKAGGEEDKVRIVY 176
Cdd:cd05844   94 VYALPLARAlgvPLVVTFHgfDITTSRAWLAASPGWPSQFQRHRRALqrpaalfVAV-SGFIRDRLLARGLPAERIHVHY 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 177 NGFDPAKASVYDPAraqqlrrelglGPQPLIGLFGRLSEWKGQHVFLEAIA--AMEGVQAVIVgsaLFGQEAYEARIRTL 254
Cdd:cd05844  173 IGIDPAKFAPRDPA-----------ERAPTILFVGRLVEKKGCDVLIEAFRrlAARHPTARLV---IAGDGPLRPALQAL 238
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 255 ASSLGldsRVRFLGF--RPDVTELMAAMDAVAHTSVVA-----EPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGETGLL 327
Cdd:cd05844  239 AAALG---RVRFLGAlpHAEVQDWMRRAEIFCLPSVTAasgdsEGLGIVLLEAAACGVPVVSSRHGGIPEAILDGETGFL 315
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 549799551 328 VPPADAPALAAALGRILTDPTLAEKLGKKGREDVMWRFSL 367
Cdd:cd05844  316 VPEGDVDALADALQALLADRALADRMGGAARAFVCEQFDI 355
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
171-366 2.71e-24

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 102.41  E-value: 2.71e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 171 KVRIVYNGFDPAkasVYDPARAQQLRRELGLGPQPLIGLFGRLS---EWKGQHVFLEAIAAMEGVQ-AVIVgsaLFGqea 246
Cdd:cd03825  162 PVVVIPNGIDTE---IFAPVDKAKARKRLGIPQDKKVILFGAESvtkPRKGFDELIEALKLLATKDdLLLV---VFG--- 232
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 247 yeariRTLASSLGLDSRVRFLGFRPDVTELM---AAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGE 323
Cdd:cd03825  233 -----KNDPQIVILPFDIISLGYIDDDEQLVdiySAADLFVHPSL-ADNLPNTLLEAMACGTPVVAFDTGGSPEIVQHGV 306
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 549799551 324 TGLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDVMWRFS 366
Cdd:cd03825  307 TGYLVPPGDVQALAEAIEWLLANPKERESLGERARALAENHFD 349
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
171-377 4.22e-24

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 102.11  E-value: 4.22e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  171 KVRIVYNGFDPAKASVYDPARAQQLRRELGLGPQPLIGLFGRLSEWKGQHVFLEAIAAM--------EGVQAVIVGSAlf 242
Cdd:TIGR03088 161 KIHQIYNGVDTERFHPSRGDRSPILPPDFFADESVVVGTVGRLQAVKDQPTLVRAFALLvrqlpegaERLRLVIVGDG-- 238
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  243 gqeAYEARIRTLASSLGLDSRVRFLGFRPDVTELMAAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDG 322
Cdd:TIGR03088 239 ---PARGACEQMVRAAGLAHLVWLPGERDDVPALMQALDLFVLPSL-AEGISNTILEAMASGLPVIATAVGGNPELVQHG 314
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 549799551  323 ETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDVMWRFSLEETCRTISAL 377
Cdd:TIGR03088 315 VTGALVPPGDAVALARALQPYVSDPAARRAHGAAGRARAEQQFSINAMVAAYAGL 369
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
60-368 1.00e-23

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 101.26  E-value: 1.00e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  60 KMLSIRRDSSFGAMLRGALDVLAVAWQLSRQAKNHDVICANSQKALFVCA--LAAKLSRRPLIWILHDIVTDpAFSAANR 137
Cdd:cd03794   65 KLGPIKKNGLIRRLLNYLSFALAALLKLLVREERPDVIIAYSPPITLGLAalLLKKLRGAPFILDVRDLWPE-SLIALGV 143
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 138 RASLTFSRLFARL----------VAVNSQETGRAFVKAGGEEDKVRIVYNGFDPakaSVYDPARAQQLRRELGLGPQPLI 207
Cdd:cd03794  144 LKKGSLLKLLKKLerklyrladaIIVLSPGLKEYLLRKGVPKEKIIVIPNWADL---EEFKPPPKDELRKKLGLDDKFVV 220
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 208 GLFGRLSEWKGQHVFLEAIAAMEGV-QAVIVgsaLFGQEAYEARIRTLASSLGLDsRVRFLGFRP--DVTELMAAMDA-V 283
Cdd:cd03794  221 VYAGNIGKAQGLETLLEAAERLKRRpDIRFL---FVGDGDEKERLKELAKARGLD-NVTFLGRVPkeEVPELLSAADVgL 296
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 284 AHTSVVAEPFGRV---VVEAMMCGRPVVATRGGGVTEIIRDGETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGRED 360
Cdd:cd03794  297 VPLKDNPANRGSSpskLFEYMAAGKPILASDDGGSDLAVEINGCGLVVEPGDPEALADAILELLDDPELRRAMGENGREL 376

                 ....*...
gi 549799551 361 VMWRFSLE 368
Cdd:cd03794  377 AEEKFSRE 384
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
276-381 6.73e-22

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 90.05  E-value: 6.73e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 276 LMAAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGETGLLVPPADAPALAAALGRILTDPTLAEKLGK 355
Cdd:COG0438   17 LLAAADVFVLPSR-SEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAILRLLEDPELRRRLGE 95
                         90       100
                 ....*....|....*....|....*.
gi 549799551 356 KGREDVMWRFSLEETCRTISALLSEV 381
Cdd:COG0438   96 AARERAEERFSWEAIAERLLALYEEL 121
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
169-369 9.51e-22

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 95.03  E-value: 9.51e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 169 EDKVRIVYNGFDPakaSVYDPARAQQLRRELGLGPQPLIGLFGRLSEWKGQHVFLEAiaaMEGVQAVIVgsaLFGQEAYE 248
Cdd:cd03795  159 KNKVRVIPLGIDK---NVYNIPRVDFENIKREKKGKKIFLFIGRLVYYKGLDYLIEA---AQYLNYPIV---IGGEGPLK 229
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 249 ARIRTLASSLGLDsRVRFLGFRPDVTE--LMAAMDAVAHTSVV-AEPFGRVVVEAMMCGRPVVATR-GGGVTEIIRDGET 324
Cdd:cd03795  230 PDLEAQIELNLLD-NVKFLGRVDDEEKviYLHLCDVFVFPSVLrSEAFGIVLLEAMMCGKPVISTNiGTGVPYVNNNGET 308
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 549799551 325 GLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDVMWRFSLEE 369
Cdd:cd03795  309 GLVVPPKDPDALAEAIDKLLSDEELRESYGENAKKRFEELFTAEK 353
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
165-328 1.04e-21

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 94.66  E-value: 1.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 165 AGGEEDKVRIVYNGFDPAkasVYDPARAqqlrrelglgPQPLIGLFGRLSEWKGQHVFLEaIAAMEGVQAVIVGSALFGQ 244
Cdd:cd03802  143 ATPPIDYLTVVHNGLDPA---DYRFQPD----------PEDYLAFLGRIAPEKGLEDAIR-VARRAGLPLKIAGKVRDED 208
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 245 EAYEARirtlasSLGLDSRVRFLGFRPDVT--ELMAAMDAVAHTSVVAEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDG 322
Cdd:cd03802  209 YFYYLQ------EPLPGPRIEFIGEVGHDEkqELLGGARALLFPINWDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHG 282

                 ....*.
gi 549799551 323 ETGLLV 328
Cdd:cd03802  283 ETGFLV 288
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
51-374 8.62e-21

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 92.43  E-value: 8.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  51 PPLLLSAGEKMLSIRRDSSFGAMLRGALDVLAVAwQLSRQAKNHDVICANSQKALFVC---ALAAKLSRRPLIWILHDI- 126
Cdd:cd03809   34 ESVLAVPPLPGELLRLLREYPELSLGVIKIKLWR-ELALLRWLQILLPKKDKPDLLHSphnTAPLLLKGCPQVVTIHDLi 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 127 -VTDPAFSAANRRasLTFSRLF------ARLVAVNSQETGRAFVKAGGE-EDKVRIVYNGFDPakasVYDPARAQQLRRE 198
Cdd:cd03809  113 pLRYPEFFPKRFR--LYYRLLLpislrrADAIITVSEATRDDIIKFYGVpPEKIVVIPLGVDP----SFFPPESAAVLIA 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 199 LGLGPQPLIGLFGRLSEWKGQHVFLEAIAAME----GVQAVIVGsalfGQEAYEARIRTLASSLGLDSRVRFLGF--RPD 272
Cdd:cd03809  187 KYLLPEPYFLYVGTLEPRKNHERLLKAFALLKkqggDLKLVIVG----GKGWEDEELLDLVKKLGLGGRVRFLGYvsDED 262
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 273 VTELMAAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVATRGGGVTEIIrdGETGLLVPPADAPALAAALGRILTDPTLAEK 352
Cdd:cd03809  263 LPALYRGARAFVFPSL-YEGFGLPVLEAMACGTPVIASNISVLPEVA--GDAALYFDPLDPESIADAILRLLEDPSLREE 339
                        330       340
                 ....*....|....*....|..
gi 549799551 353 LGKKGREDVMWrFSLEETCRTI 374
Cdd:cd03809  340 LIRKGLERAKK-FSWEKTAEKT 360
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
128-372 4.02e-20

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 90.43  E-value: 4.02e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 128 TDPAFSAANRRASLTFSRLFARLVaVNSQETGRAFVKAGGEedKVRIVYNGFDpakASVYDPARAQQ-LRRELGLGPQPL 206
Cdd:cd03814  127 TLGPLSWLAWAYLRWFHNPFDTTL-VPSPSIARELEGHGFE--RVRLWPRGVD---TELFHPSRRDAaLRRRLGPPGRPL 200
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 207 IGLFGRLSEWKGQHVFLEAI---AAMEGVQAVIVGSalfGQEAYEARIRTLasslgldsRVRFLGFR--PDVTELMAAMD 281
Cdd:cd03814  201 LLYVGRLAPEKNLEALLDADlplAASPPVRLVVVGD---GPARAELEARGP--------DVIFTGFLtgEELARAYASAD 269
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 282 AVAHTSVvAEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGREdV 361
Cdd:cd03814  270 VFVFPSR-TETFGLVVLEAMASGLPVVAADAGGPRDIVRPGGTGALVEPGDAAAFAAALRALLEDPELRRRMAARARA-E 347
                        250
                 ....*....|.
gi 549799551 362 MWRFSLEETCR 372
Cdd:cd03814  348 AERYSWEAFLD 358
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
80-368 4.60e-20

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 90.49  E-value: 4.60e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  80 VLAVAWQLSRQAKNH--DVICANSQKALFVCALAAK--LSRR-PLIWILH--DIV---TDPAFSAANRrasltfsrlFA- 148
Cdd:cd04962   69 TLALASKIVEVAKEHklDVLHAHYAIPHASCAYLAReiLGEKiPIVTTLHgtDITlvgYDPSLQPAVR---------FSi 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 149 ----RLVAVNS---QETGRAFvkagGEEDKVRIVYNGFDpakASVYDPARAQQLRRELGLGPQPLIGL----FGRLSE-W 216
Cdd:cd04962  140 nksdRVTAVSSslrQETYELF----DVDKDIEVIHNFID---EDVFKRKPAGALKRRLLAPPDEKVVIhvsnFRPVKRiD 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 217 KGQHVFlEAIAAMEGVQAVIVGSalfGQEayEARIRTLASSLGLDSRVRFLGFRPDVTELMAAMDAVAHTSVVaEPFGRV 296
Cdd:cd04962  213 DVVRVF-ARVRRKIPAKLLLVGD---GPE--RVPAEELARELGVEDRVLFLGKQDDVEELLSIADLFLLPSEK-ESFGLA 285
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 549799551 297 VVEAMMCGRPVVATRGGGVTEIIRDGETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDVMWRFSLE 368
Cdd:cd04962  286 ALEAMACGVPVVSSNAGGIPEVVKHGETGFLSDVGDVDAMAKSALSILEDDELYNRMGRAARKRAAERFDPE 357
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
211-368 1.37e-18

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 85.75  E-value: 1.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 211 GRLSEWKGQHVFLEAIA----AMEGVQAVIVGSalfGQEayEARIRTLASSLGLDSRVRFLGFRPDVTELMAAMDAVAHT 286
Cdd:cd03820  188 GRLTYQKGFDLLIEAWAliakKHPDWKLRIYGD---GPE--REELEKLIDKLGLEDRVKLLGPTKNIAEEYANSSIFVLS 262
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 287 SVVaEPFGRVVVEAMMCGRPVVATRG-GGVTEIIRDGETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDvMWRF 365
Cdd:cd03820  263 SRY-EGFPMVLLEAMAYGLPIISFDCpTGPSEIIEDGENGLLVPNGDVDALAEALLRLMEDEELRKKMGKNARKN-AERF 340

                 ...
gi 549799551 366 SLE 368
Cdd:cd03820  341 SIE 343
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
210-328 7.76e-18

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 81.68  E-value: 7.76e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 210 FGRLSEWKGQHVFLEAIAA----MEGVQAVIVGSAlfgqeAYEARIRTLASSLGLDSRVRFLGFRPDVTELMAAM---DA 282
Cdd:cd01635  116 VGRLVPEKGIDLLLEALALlkarLPDLVLVLVGGG-----GEREEEEALAAALGLLERVVIIGGLVDDEVLELLLaaaDV 190
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 549799551 283 VAHTSVvAEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGETGLLV 328
Cdd:cd01635  191 FVLPSR-SEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
172-368 2.11e-16

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 79.83  E-value: 2.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 172 VRIVYNGFDPakaSVYDPARAQQLRRELGLGPQPLIGLF-GRLSEWKGQHVFLEA----IAAMEGVQAVIVG----SALF 242
Cdd:PRK15484 163 ISIVPNGFCL---ETYQSNPQPNLRQQLNISPDETVLLYaGRISPDKGILLLMQAfeklATAHSNLKLVVVGdptaSSKG 239
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 243 GQEAYEARIRTLASSLGldSRVRFLGFRP--DVTELMAAMDAVAHTSVVAEPFGRVVVEAMMCGRPVVATRGGGVTEIIR 320
Cdd:PRK15484 240 EKAAYQKKVLEAAKRIG--DRCIMLGGQPpeKMHNYYPLADLVVVPSQVEEAFCMVAVEAMAAGKPVLASTKGGITEFVL 317
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 549799551 321 DGETGL-LVPPADAPALAAALGRILTDPTLAEkLGKKGREDVMWRFSLE 368
Cdd:PRK15484 318 EGITGYhLAEPMTSDSIISDINRTLADPELTQ-IAEQAKDFVFSKYSWE 365
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
155-367 2.02e-15

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 76.71  E-value: 2.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 155 SQETGRAFV--KAGGEeDKVRIVYNGFDPAKASvYDPARAQQLRRELGL-GPQPLIGLFGRLSEWKGQHVFLEAIAAM-- 229
Cdd:cd04951  138 SREALDEFIakKAFSK-NKSVPVYNGIDLNKFK-KDINVRLKIRNKLNLkNDEFVILNVGRLTEAKDYPNLLLAISELil 215
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 230 --EGVQAVIVGSAlfgqeayEAR--IRTLASSLGLDSRVRFLGFRPDVTELMAAMDAVAHTSVvAEPFGRVVVEAMMCGR 305
Cdd:cd04951  216 skNDFKLLIAGDG-------PLRneLERLICNLNLVDRVILLGQISNISEYYNAADLFVLSSE-WEGFGLVVAEAMACER 287
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 549799551 306 PVVATRGGGVTEIIRDGEtgLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDVMWRFSL 367
Cdd:cd04951  288 PVVATDAGGVAEVVGDHN--YVVPVSDPQLLAEKIKEIFDMSDEERDILGNKNEYIAKNFSI 347
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
170-369 4.47e-15

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 75.86  E-value: 4.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 170 DKVRIVYNGFDPAKASVYDPARAQQLRRELGLGPQPLIGLFGR-LSEWKGQHVFLEAIAAMEG----VQAVIVG--SALF 242
Cdd:cd03818  179 DRISVIHDGVDTDRLAPDPAARLRLLNGTELKAGDPVITYVARnLEPYRGFHVFMRALPRIQArrpdARVVVVGgdGVSY 258
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 243 GQEAYEA---RIRTLASSLGLDSRVRFLGFRP--DVTELMAAMDAvaHTsVVAEPFgrV----VVEAMMCGRPVVATRGG 313
Cdd:cd03818  259 GSPPPDGgswKQKMLAELGVDLERVHFVGKVPydQYVRLLQLSDA--HV-YLTYPF--VlswsLLEAMACGCPVIGSDTA 333
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 549799551 314 GVTEIIRDGETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDVMWRFSLEE 369
Cdd:cd03818  334 PVREVIRDGRNGLLVDFFDPDALAAAVLELLEDPDRAAALRRAARRTVERSDSLDV 389
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
5-308 2.93e-14

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 73.09  E-value: 2.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551   5 LFVSHTGEKGGAELFLADIVKAGPRS-WRACFLsgggaADDLAECGRPPLLLSAGEKMLSI-RRDSSFGAMLRGALDVLA 82
Cdd:cd03812    3 LHIVGGMNVGGIETFLMNLYRKLDKSkIEFDFL-----ATSDDKGEYDEELEELGGKIFYIpPKKKNIIKYFIKLLKLIK 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  83 vawqlsrqAKNHDVICANSQKALFVCALAAKLSRRPlIWILHDIVTDpafsAANRRASLTFSRLFARLVAVN-------S 155
Cdd:cd03812   78 --------KEKYDIVHVHGSSSNGIILLLAAKAGVP-VRIAHSHNTK----DSSIKLRKIRKNVLKKLIERLstkylacS 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 156 QETGRaFVKAGGEEDKVRIVYNGFDpAKASVYDPARAQQLRRELGLGPQPLIGLFGRLSEWKGQ----HVFLEAIAAMEG 231
Cdd:cd03812  145 EDAGE-WLFGEVENGKFKVIPNGID-IEKYKFNKEKRRKRRKLLILEDKLVLGHVGRFNEQKNHsfliDIFEELKKKNPN 222
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 549799551 232 VQAVIVGSalfGQEAYEarIRTLASSLGLDSRVRFLGFRPDVTELMAAMDAVAHTSVVaEPFGRVVVEAMMCGRPVV 308
Cdd:cd03812  223 VKLVLVGE---GELKEK--IKEKVKELGLEDKVIFLGFRNDVSEILSAMDVFLFPSLY-EGLPLVAVEAQASGLPCL 293
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
148-322 2.99e-14

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 73.17  E-value: 2.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 148 ARLVAVNSQETGRAFVKAGGEEdKVRIVYNGFDPakaSVYDPARAQqlRRELGLGP-QPLIGLFGRLSEWKGQHVFLEAI 226
Cdd:cd03821  153 AALVHFTSEQEADELRRFGLEP-PIAVIPNGVDI---PEFDPGLRD--RRKHNGLEdRRIILFLGRIHPKKGLDLLIRAA 226
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 227 AAME----GVQAVIVGSalfgQEAYEARIRTLASSLGLDSRVRFLGFRPD--VTELMAAMDAVAHTSVvAEPFGRVVVEA 300
Cdd:cd03821  227 RKLAeqgrDWHLVIAGP----DDGAYPAFLQLQSSLGLGDRVTFTGPLYGeaKWALYASADLFVLPSY-SENFGNVVAEA 301
                        170       180
                 ....*....|....*....|..
gi 549799551 301 MMCGRPVVATRGGGVTEIIRDG 322
Cdd:cd03821  302 LACGLPVVITDKCGLSELVEAG 323
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
143-361 4.53e-14

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 72.48  E-value: 4.53e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 143 FSRLFAR--LVAVNSQETGRAFVKAGGEEDKVRIVYNGFDPAK---ASVYDPARaQQLRrelglgpqplIGLFGRLSEWK 217
Cdd:cd03799  119 YPQLFAQgdLFLPNCELFKHRLIALGCDEKKIIVHRSGIDCNKfrfKPRYLPLD-GKIR----------ILTVGRLTEKK 187
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 218 GQHVFLEAIAAMEGVQAVIvGSALFGQEAYEARIRTLASSLGLDSRVRFLGFRP--DVTELMAAMDAVAHTSVVA----- 290
Cdd:cd03799  188 GLEYAIEAVAKLAQKYPNI-EYQIIGDGDLKEQLQQLIQELNIGDCVKLLGWKPqeEIIEILDEADIFIAPSVTAadgdq 266
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 549799551 291 EPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDV 361
Cdd:cd03799  267 DGPPNTLKEAMAMGLPVISTEHGGIPELVEDGVSGFLVPERDAEAIAEKLTYLIEHPAIWPEMGKAGRARV 337
PelF NF038011
GT4 family glycosyltransferase PelF; Proteins of this family are components of the ...
163-319 1.48e-13

GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter.


Pssm-ID: 411604 [Multi-domain]  Cd Length: 489  Bit Score: 71.89  E-value: 1.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 163 VKAGGEEDKVRIVYNGFDPAKasvYDPARAQqlRRElglGPQPLIGLFGRLSEWKGQHVFLEAI----AAMEGVQAVIVG 238
Cdd:NF038011 273 IADGAPPERTRVIPNGIDLPR---LAPLRAQ--RPA---GIPPVVGLIGRVVPIKDIKTFIRAMrtvvRAMPEAEGWIVG 344
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 239 SAlfgQE--AYEARIRTLASSLGLDSRVRFLGFRpDVTELMAAMDAVAHTSVV-AEPFgrVVVEAMMCGRPVVATRGGGV 315
Cdd:NF038011 345 PE---EEdpAYAAECRSLVASLGLQDKVKFLGFQ-KIDDLLPQVGLMVLSSISeALPL--VVLEAFAAGVPVVTTDVGSC 418

                 ....
gi 549799551 316 TEII 319
Cdd:NF038011 419 RQLI 422
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
174-323 4.10e-13

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 69.73  E-value: 4.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  174 IVYNGFDPAKASVYDPARAQQLRRELGLGPQPLIGLFGRLSEWKGQHVFLEAIAAMEG----VQAVIVGSA-LFGQEAYE 248
Cdd:TIGR04047 163 VVPNGVDAARFSPAADAADAALRRRLGLRGGPYVLAVGGIEPRKNTIDLLEAFALLRArrpqAQLVIAGGAtLFDYDAYR 242
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 549799551  249 ARIRTLASSLGLD-SRVRFLGFRPD--VTELMAAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGE 323
Cdd:TIGR04047 243 REFRARAAELGVDpGPVVITGPVPDadLPALYRCADAFAFPSL-KEGFGLVVLEALASGIPVVASDIAPFTEYLGRFD 319
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
211-327 6.39e-13

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 69.24  E-value: 6.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 211 GRLSEWKGQHVFLEAIAAMeGVQAVIVGSalfGQEayEARIRTLASSlgldsRVRFLGFRPDVTELMAAMDAVAHTSVVA 290
Cdd:cd03804  206 SRLVPYKRIDLAVEAFNEL-PKRLVVIGD---GPD--LDRLRAMASP-----NVEFLGYQPDEVLKELLSKARAFVFAAE 274
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 549799551 291 EPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGETGLL 327
Cdd:cd03804  275 EDFGIVPVEAQACGTPVIAFGKGGALETVRPGPTGIL 311
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
143-368 4.58e-11

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 63.76  E-value: 4.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 143 FSRLFARLVAVNSQETGRAFVKA--GGEEDKVRIVYngfDPAKASVYDPARAQQLRRELGLgpqpliglfgrlseWKGQH 220
Cdd:cd03805  150 FTTGMADQIVVNSNFTAGVFKKTfpSLAKNPPEVLY---PCVDTDSFDSTSEDPDPGDLIA--------------KSNKK 212
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 221 VFLE------------AIAAM----------EGVQAVIVGSalfgqeaYEARI----------RTLA-SSLGLDSRVRFL 267
Cdd:cd03805  213 FFLSinrferkknialAIEAFaklkqklpefENVRLVIAGG-------YDPRVaenveyleelQRLAeELLNVEDQVLFL 285
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 268 gfrPDVTE-----LMAAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGETGLLVPPADAPALAAALgR 342
Cdd:cd03805  286 ---RSISDsqkeqLLSSALALLYTPS-NEHFGIVPLEAMYAGKPVIACNSGGPLETVVEGVTGFLCEPTPEAFAEAML-K 360
                        250       260
                 ....*....|....*....|....*.
gi 549799551 343 ILTDPTLAEKLGKKGREDVMWRFSLE 368
Cdd:cd03805  361 LANDPDLADRMGAAGRKRVKEKFSRE 386
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
135-364 2.17e-10

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 62.04  E-value: 2.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 135 ANRRASLTFsrlfarlvaVNSQETGRAFVKAGGEE-DKVRIVYNGFDpakASVYDPA-RAQQLRREL--GLGPQPLIGLF 210
Cdd:PLN02871 202 LHRAADLTL---------VTSPALGKELEAAGVTAaNRIRVWNKGVD---SESFHPRfRSEEMRARLsgGEPEKPLIVYV 269
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 211 GRLSEWKGQHVFLEAIAAMEGVQAVIVGSAlfgqeAYEARIRTLASslglDSRVRFLG-FRPDvtELMAAMdAVAHTSVV 289
Cdd:PLN02871 270 GRLGAEKNLDFLKRVMERLPGARLAFVGDG-----PYREELEKMFA----GTPTVFTGmLQGD--ELSQAY-ASGDVFVM 337
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 290 ---AEPFGRVVVEAMMCGRPVVATRGGGVTEIIRD---GETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGREDVM- 362
Cdd:PLN02871 338 pseSETLGFVVLEAMASGVPVVAARAGGIPDIIPPdqeGKTGFLYTPGDVDDCVEKLETLLADPELRERMGAAAREEVEk 417

                 ....
gi 549799551 363 --WR 364
Cdd:PLN02871 418 wdWR 421
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
276-365 5.38e-10

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 60.41  E-value: 5.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 276 LMAAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGETGLLVPPADAPALAAAlgRILTDPTLAEKLGK 355
Cdd:cd03792  276 LQRAATVVLQLST-REGFGLTVSEALWKGKPVIATPAGGIPLQVIDGETGFLVNSVEGAAVRIL--RLLTDPELRRKMGL 352
                         90
                 ....*....|
gi 549799551 356 KGREDVMWRF 365
Cdd:cd03792  353 AAREHVRDNF 362
GT28_Beta-DGS-like cd17507
beta-diglucosyldiacylglycerol synthase and similar proteins; beta-diglucosyldiacylglycerol ...
153-311 2.50e-09

beta-diglucosyldiacylglycerol synthase and similar proteins; beta-diglucosyldiacylglycerol synthase (processive diacylglycerol beta-glucosyltransferase EC 2.4.1.315) is involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. This family of glycosyltransferases also contains plant major galactolipid synthase (chloroplastic monogalactosyldiacylglycerol synthase 1 EC 2.4.1.46). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340861 [Multi-domain]  Cd Length: 364  Bit Score: 58.10  E-value: 2.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 153 VNSQETGRAFVKAGGEEDKVRIvyNGF--DPAKASVYDparAQQLRRELGLGPQPLIGLFGrlsewkGQHVFLEAIAAMe 230
Cdd:cd17507  148 VASEEVKRELVERGVTPSQIKV--TGIpvRPSFAEVRD---KDEARNELNLSPDKPTVLLM------GGGGGMGPVKET- 215
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 231 gVQAvIVGSALFGQEAY-----EARIRTLASSLGLDSRVRFLGFRPDVTELMAAMDAvahtsVVAEPFGRVVVEAMMCGR 305
Cdd:cd17507  216 -VEA-LLDSLRAGQVLVvcgknKKLYEKLSGLEEDYINVRVLGYVDDMNELMAASDL-----VITKPGGLTISEALARGL 288

                 ....*.
gi 549799551 306 PVVATR 311
Cdd:cd17507  289 PVIIYD 294
GT5_Glycogen_synthase_DULL1-like cd03791
Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 ...
193-325 5.13e-09

Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.


Pssm-ID: 340822 [Multi-domain]  Cd Length: 474  Bit Score: 57.57  E-value: 5.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 193 QQLRRELGLgPQ----PLIGLFGRLSEWKGQHVFLEAIAAM--EGVQAVIVGSalfGQEAYEARIRTLASSLGldSRVRF 266
Cdd:cd03791  280 AALQKELGL-PVdpdaPLFGFVGRLTEQKGVDLILDALPELleEGGQLVVLGS---GDPEYEQAFRELAERYP--GKVAV 353
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 549799551 267 -LGF-RPDVTELMAAMDAVAHTSVVaEPFGRVVVEAMMCGRPVVATRGGG----VTEIIRDGETG 325
Cdd:cd03791  354 vIGFdEALAHRIYAGADFFLMPSRF-EPCGLVQMYAMRYGTLPIVRRTGGladtVFDYDPETGEG 417
GT4_mannosyltransferase-like cd03822
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ...
91-357 6.73e-09

mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.


Pssm-ID: 340849 [Multi-domain]  Cd Length: 370  Bit Score: 57.01  E-value: 6.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  91 AKNHDVICANSQKALF-----VCALAAKLS-RRPLIWILHDIVTDPAFSAANRRasltfsrLFARLVAVNsqeTGRAFVK 164
Cdd:cd03822   73 FKKPDVVHIQHEFGIFggkygLYALGLLLHlRIPVITTLHTVLDLSDPGKQALK-------VLFRIATLS---ERVVVMA 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 165 AGGEEDKVRivYNGFDPAKAS-----VYDPARAQQLRRELGLGPQ--PLIGLFGRLSEWKGQHVFLEAI----AAMEGVQ 233
Cdd:cd03822  143 PISRFLLVR--IKLIPAVNIEviphgVPEVPQDPTTALKRLLLPEgkKVILTFGFIGPGKGLEILLEALpelkAEFPDVR 220
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 234 AVIVG----SALFGQ-EAYEARIrtlASSLGLDSRVRF-LGFRP--DVTELMAAMDavahtsVVAEPF---GR----VVV 298
Cdd:cd03822  221 LVIAGelhpSLARYEgERYRKAA---IEELGLQDHVDFhNNFLPeeEVPRYISAAD------VVVLPYlntEQsssgTLS 291
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 549799551 299 EAMMCGRPVVATRGGGVTEIIRDGEtGLLVPPADAPALAAALGRILTDPTLAEKLGKKG 357
Cdd:cd03822  292 YAIACGKPVISTPLRHAEELLADGR-GVLVPFDDPSAIAEAILRLLEDDERRQAIAERA 349
PRK15179 PRK15179
Vi polysaccharide biosynthesis protein TviE; Provisional
8-369 7.72e-09

Vi polysaccharide biosynthesis protein TviE; Provisional


Pssm-ID: 185101 [Multi-domain]  Cd Length: 694  Bit Score: 57.35  E-value: 7.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551   8 SHTgEKGGAELFLADIVKAG-PRS-------WRACFLSGGGAAddLAECGR--PPLLLSAGEKMLSIRRDSSFgamlrga 77
Cdd:PRK15179 332 SLR-SREGADFFAATLADAGiPVSvysdmqaWGGCEFSSLLAP--YREYLRflPKQIIEGTTKLTDVMRSSVP------- 401
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  78 lDVLAVaWQlsrqaknhdvicansQKALFVCALAAKLSRRPLIwilHDIVTDPAFSAANRRASLTFSRLFARLVAV---- 153
Cdd:PRK15179 402 -SVVHI-WQ---------------DGSIFACALAALLAGVPRI---VLSVRTMPPVDRPDRYRVEYDIIYSELLKMrgva 461
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 154 ---NSQETGRAFVK-AGGEEDKVRIVYNGFDPAK--ASVYDPARAQQLRRELGLGPQPLIGLFgRLSEWKGQHVFLEA-- 225
Cdd:PRK15179 462 lssNSQFAAHRYADwLGVDERRIPVVYNGLAPLKsvQDDACTAMMAQFDARTSDARFTVGTVM-RVDDNKRPFLWVEAaq 540
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 226 --IAAMEGVQAVIVGSALFGQEayearIRTLASSLGLDSRVRFLGFRPDVTELMAAMDAVAHTSVVaEPFGRVVVEAMMC 303
Cdd:PRK15179 541 rfAASHPKVRFIMVGGGPLLES-----VREFAQRLGMGERILFTGLSRRVGYWLTQFNAFLLLSRF-EGLPNVLIEAQFS 614
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 549799551 304 GRPVVATRGGGVTEIIRDGETGLLVPPADAPA--LAAALGRILTDPTLAEKLGKKGREDVMWRFSLEE 369
Cdd:PRK15179 615 GVPVVTTLAGGAGEAVQEGVTGLTLPADTVTApdVAEALARIHDMCAADPGIARKAADWASARFSLNQ 682
sucrsPsyn_pln TIGR02468
sucrose phosphate synthase/possible sucrose phosphate phosphatase, plant; Members of this ...
271-382 2.29e-07

sucrose phosphate synthase/possible sucrose phosphate phosphatase, plant; Members of this family are sucrose-phosphate synthases of plants. This enzyme is known to exist in multigene families in several species of both monocots and dicots. The N-terminal domain is the glucosyltransferase domain. Members of this family also have a variable linker region and a C-terminal domain that resembles sucrose phosphate phosphatase (SPP) (EC 3.1.3.24) (see TIGR01485), the next and final enzyme of sucrose biosynthesis. The SPP-like domain likely serves a binding and not a catalytic function, as the reported SPP is always encoded by a distinct protein.


Pssm-ID: 274147 [Multi-domain]  Cd Length: 1050  Bit Score: 52.86  E-value: 2.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551   271 PDVTELMAAMDAVAHTSVVAEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGETGLLVPPADAPALAAALGRILTDPTLA 350
Cdd:TIGR02468  562 PDIYRLAAKTKGVFINPAFIEPFGLTLIEAAAHGLPMVATKNGGPVDIHRVLDNGLLVDPHDQQAIADALLKLVADKQLW 641
                           90       100       110
                   ....*....|....*....|....*....|..
gi 549799551   351 EKLGKKGREDVMwRFSLEETCRTisaLLSEVA 382
Cdd:TIGR02468  642 AECRQNGLKNIH-LFSWPEHCKT---YLSRIA 669
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
59-182 2.77e-07

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 49.84  E-value: 2.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551   59 EKMLSIRRDSSFGAMLRGALDVLAVAWQLSRQAKNH--DVICANSQKALFVCALAAKLSRR-PLIWILHDIVTD------ 129
Cdd:pfam13439  35 EVVRVVRVPRVPLPLPPRLLRSLAFLRRLRRLLRRErpDVVHAHSPFPLGLAALAARLRLGiPLVVTYHGLFPDykrlga 114
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 549799551  130 --PAFSAANRRASLTFSRLFARLVAVnSQETGRAFVKA-GGEEDKVRIVYNGFDPA 182
Cdd:pfam13439 115 rlSPLRRLLRRLERRLLRRADRVIAV-SEAVADELRRLyGVPPEKIRVIPNGVDLE 169
GlgA COG0297
Glycogen synthase [Carbohydrate transport and metabolism];
193-255 2.21e-06

Glycogen synthase [Carbohydrate transport and metabolism];


Pssm-ID: 440066 [Multi-domain]  Cd Length: 476  Bit Score: 49.32  E-value: 2.21e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 549799551 193 QQLRRELGLGPQ---PLIGLFGRLSEWKGQHVFLEAIAAM--EGVQAVIVGSalfGQEAYEARIRTLA 255
Cdd:COG0297  281 AALQEELGLPVDpdaPLIGMVSRLTEQKGLDLLLEALDELleEDVQLVVLGS---GDPEYEEAFRELA 345
Glyco_trans_4_4 pfam13579
Glycosyl transferase 4-like domain;
81-178 7.95e-06

Glycosyl transferase 4-like domain;


Pssm-ID: 433325 [Multi-domain]  Cd Length: 158  Bit Score: 45.47  E-value: 7.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551   81 LAVAWQLSR--QAKNHDVICANSQKALFVCALAAKLSRRPLIWILHDIVTDPAFSAAnRRASLTFSRLFAR---LVAVNS 155
Cdd:pfam13579  57 LAALRRLRRllRAERPDVVHAHSPTAGLAARLARRRRGVPLVVTVHGLALDYGSGWK-RRLARALERRLLRradAVVVVS 135
                          90       100
                  ....*....|....*....|...
gi 549799551  156 QETGRAFVKAGGEEDKVRIVYNG 178
Cdd:pfam13579 136 EAEAELLRALGVPAARVVVVPNG 158
PLN00142 PLN00142
sucrose synthase
291-325 1.39e-05

sucrose synthase


Pssm-ID: 215073 [Multi-domain]  Cd Length: 815  Bit Score: 47.28  E-value: 1.39e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 549799551 291 EPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGETG 325
Cdd:PLN00142 677 EAFGLTVVEAMTCGLPTFATCQGGPAEIIVDGVSG 711
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
211-359 1.75e-05

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 46.14  E-value: 1.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 211 GRLSEWKGQHVFLEAIAamegvQAVIVGSA----LFGQEAYEARIRTLASSLGLDSRVRFLGFRPDVTELMAAMDAVAHT 286
Cdd:cd04949  167 SRLAPEKQLDHLIEAVA-----KAVKKVPEitldIYGYGEEREKLKKLIEELHLEDNVFLKGYHSNLDQEYQDAYLSLLT 241
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 549799551 287 SVvAEPFGRVVVEAMMCGRPVVATRGG-GVTEIIRDGETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGRE 359
Cdd:cd04949  242 SQ-MEGFGLTLMEAIGHGLPVVSYDVKyGPSELIEDGENGYLIEKNNIDALADKIIELLNDPEKLQQFSEESYK 314
glgA PRK00654
glycogen synthase GlgA;
192-269 2.43e-05

glycogen synthase GlgA;


Pssm-ID: 234809 [Multi-domain]  Cd Length: 466  Bit Score: 46.26  E-value: 2.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 192 AQQLRRELGLgPQ---PLIGLFGRLSEWKGQHVFLEAIAAM--EGVQAVIVGSalfGQEAYEARIRTLASSLGldSRVRF 266
Cdd:PRK00654 268 KRALQERFGL-PDddaPLFAMVSRLTEQKGLDLVLEALPELleQGGQLVLLGT---GDPELEEAFRALAARYP--GKVGV 341

                 ....
gi 549799551 267 -LGF 269
Cdd:PRK00654 342 qIGY 345
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
243-327 3.95e-05

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 45.14  E-value: 3.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 243 GQEAYEARIRTLASSLGLDSRVRFLGFRP--DVTEL--MAAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVATRGGGVTEI 318
Cdd:cd04946  264 GGGPLKERLEKLAENKLENVKVNFTGEVSnkEVKQLykENDVDVFVNVSE-SEGIPVSIMEAISFGIPVIATNVGGTREI 342

                 ....*....
gi 549799551 319 IRDGETGLL 327
Cdd:cd04946  343 VENETNGLL 351
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
285-368 1.83e-04

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 39.89  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  285 HTSVVAEPFGRVVVEAMMCGRPVVATRGGGVTEIIRDGETGLLVPPADAPALAAAlgRILTDPTLAEKLGKKGREDVMWR 364
Cdd:pfam13524   4 NPSRRPDSPNMRVFEAAACGAPLLTDRTPGLEELFEPGEEILLYRDPEELAEKIR--YLLEHPEERRAIAAAGRERVLAE 81

                  ....
gi 549799551  365 FSLE 368
Cdd:pfam13524  82 HTYA 85
LpxB COG0763
Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis]; Lipid A disaccharide ...
181-319 4.42e-04

Lipid A disaccharide synthetase [Cell wall/membrane/envelope biogenesis]; Lipid A disaccharide synthetase is part of the Pathway/BioSystem: Lipid A biosynthesis


Pssm-ID: 440526  Cd Length: 378  Bit Score: 41.97  E-value: 4.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 181 PAKASVYDPARAQQLRRELGLGP-QPLIGLF-G-RLSEWKgQH--VFLEAIAAME----GVQAVIVGSAlfgqEAYEARI 251
Cdd:COG0763  161 PLADEIPLEPDRAAARARLGLDPdKPVIALLpGsRRSEIK-RLlpVFLEAAKLLAarrpDLQFVVPLAP----SLRRELI 235
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 549799551 252 RTLASSLGLDSRVrflgFRPDVTELMAAMDAVAHTSvvaepfGRVVVEAMMCGRP-VVATRGGGVTEII 319
Cdd:COG0763  236 EAALADWPLPVTL----VDGQTYDAMAAADAALVAS------GTATLEAALLGVPmVVAYKVSPLTYWI 294
PRK14099 PRK14099
glycogen synthase GlgA;
180-326 7.86e-04

glycogen synthase GlgA;


Pssm-ID: 237610 [Multi-domain]  Cd Length: 485  Bit Score: 41.24  E-value: 7.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 180 DPAKASVYD----PARA---QQLRRELGLGPQP---LIGLFGRLSEWKGQHVFLEAIAAM--EGVQAVIVGSalfGQEAY 247
Cdd:PRK14099 261 DELIAATYDvetlAARAankAALQARFGLDPDPdalLLGVISRLSWQKGLDLLLEALPTLlgEGAQLALLGS---GDAEL 337
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 248 EARIRtlASSLGLDSRV-RFLGFRPDVTELM-AAMDAVAHTSVVaEPFGRVVVEAMMCGR-PVVATRGGGVTEIIRDGET 324
Cdd:PRK14099 338 EARFR--AAAQAYPGQIgVVIGYDEALAHLIqAGADALLVPSRF-EPCGLTQLCALRYGAvPVVARVGGLADTVVDANEM 414

                 ..
gi 549799551 325 GL 326
Cdd:PRK14099 415 AI 416
PRK15490 PRK15490
Vi polysaccharide biosynthesis glycosyltransferase TviE;
241-328 1.30e-03

Vi polysaccharide biosynthesis glycosyltransferase TviE;


Pssm-ID: 185387 [Multi-domain]  Cd Length: 578  Bit Score: 40.84  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 241 LFGQEAYEARIRTLASSLGLDSRVRFLGFRPDVTELMAAMDAVAHTSVVaEPFGRVVVEAMMCGRPVVATRGGGVTEIIR 320
Cdd:PRK15490 434 LVGDGDLRAEAQKRAEQLGILERILFVGASRDVGYWLQKMNVFILFSRY-EGLPNVLIEAQMVGVPVISTPAGGSAECFI 512

                 ....*...
gi 549799551 321 DGETGLLV 328
Cdd:PRK15490 513 EGVSGFIL 520
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
260-318 1.61e-03

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 40.30  E-value: 1.61e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 549799551 260 LDSRVRFLGFRP--DVTELMAAMDAVAHTSVvAEPFGRVVVEAMMCGRPVVATRGGGVTEI 318
Cdd:cd03796  248 LQDRVELLGAVPheEVRDVLVQGHIFLNTSL-TEAFCIAIVEAASCGLLVVSTRVGGIPEV 307
PRK10307 PRK10307
colanic acid biosynthesis glycosyltransferase WcaI;
68-359 1.83e-03

colanic acid biosynthesis glycosyltransferase WcaI;


Pssm-ID: 236670 [Multi-domain]  Cd Length: 412  Bit Score: 39.96  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551  68 SSFGAMLRGALdvlavaWqlsrqaKNHDVICAnsQKALFvCA----LAAKLSRRPLIWILHDIVTDPAF------SAANR 137
Cdd:PRK10307  94 SSFFPLLAQRR------W------RPDRVIGV--VPTLF-CApgarLLARLSGARTWLHIQDYEVDAAFglgllkGGKVA 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 138 RASLTFSRLFARLVAVNSQETGRAFVKA---GGEEDKVRIVYNGFDPAKASVYDPARAQQLRRELGLGPQPLIGLF-GRL 213
Cdd:PRK10307 159 RLATAFERSLLRRFDNVSTISRSMMNKArekGVAAEKVIFFPNWSEVARFQPVADADVDALRAQLGLPDGKKIVLYsGNI 238
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549799551 214 SEWKGQHVFLEAIAAMEGVQAVIVgsALFGQEAYEARIRTLASSLGLDsRVRFLGFRPdvTELMAAMDAVAHTSVVaePF 293
Cdd:PRK10307 239 GEKQGLELVIDAARRLRDRPDLIF--VICGQGGGKARLEKMAQCRGLP-NVHFLPLQP--YDRLPALLKMADCHLL--PQ 311
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 549799551 294 GRVVVEAMM---------CGRPVVAT--RGGGVTEIIRdgETGLLVPPADAPALAAALGRILTDPTLAEKLGKKGRE 359
Cdd:PRK10307 312 KAGAADLVLpskltnmlaSGRNVVATaePGTELGQLVE--GIGVCVEPESVEALVAAIAALARQALLRPKLGTVARE 386
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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