|
Name |
Accession |
Description |
Interval |
E-value |
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
22-393 |
1.59e-69 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 224.41 E-value: 1.59e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 22 WAAVVSLSLGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIIS 101
Cdd:PRK10213 19 WSAVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 102 STLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFV 181
Cdd:PRK10213 99 CLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFN 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 182 VAGVLGVIALAVQLLTVPSLPPAGAPGLSTMFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEDVPQLGVEAISLVL 261
Cdd:PRK10213 179 AAAVMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 262 LIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFITRVASDEA 341
Cdd:PRK10213 259 LSFGIASFVGTSLSSFILKRSVKLALAGAPLVLAVSALVLTLWGSDKIVATGVAIIWGLTFALVPVGWSTWITRSLADQA 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 549800291 342 ESAGALLLTTFQIAISSGAVLGGLLIDLQGATMVFVFVAIAALLGASLMASR 393
Cdd:PRK10213 339 EKAGSIQVAVIQLANTCGAAIGGYALDNIGLTSPLMLSGTLMLLTALLVTAK 390
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
25-391 |
1.24e-56 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 190.07 E-value: 1.24e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 25 VVSLSLGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIISSTL 104
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 105 AAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAG 184
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 185 VLGVIALAVQLLTVPSLPPAGAPGL---STMFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEDVPQLGVEAISLVL 261
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLgllSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 262 LIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFITRVASDEA 341
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 549800291 342 ESAGALLLTTFQIAISSGAVLGGLLIDLQGATMVFVFVAIAALLGASLMA 391
Cdd:cd17324 321 GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
22-397 |
3.48e-41 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 149.66 E-value: 3.48e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 22 WAAVVSLSLGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIIS 101
Cdd:PRK03545 8 WLRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 102 STLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFV 181
Cdd:PRK03545 88 HVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 182 VAGVLGVIALAVQLLTVPSLPPAGAPGLSTMFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEDVPQLGVEAISLVL 261
Cdd:PRK03545 168 AIGGGALITLLLLIKLLPLLPSEHSGSLKSLPLLFRRPALVSLYLLTVVVVTAHFTAYSYIEPFVQQVAGLSENFATLLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 262 LIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFITRVASDEA 341
Cdd:PRK03545 248 LLFGGAGIIGSVLFSRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGLAMQVKVLKLAPDAT 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 549800291 342 ESAGALLLTTFQIAISSGAVLGGLLIDLQGATMVFVF---VAIAALLGASLMASRRGVV 397
Cdd:PRK03545 328 DVAMALFSGIFNIGIGAGALLGNQVSLHLGLSSIGYVgaaLALAALVWSILIFRRFPVT 386
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
18-353 |
1.05e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 115.07 E-value: 1.05e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 18 PDAKWAAVVSLSLGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTL 97
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 98 LIISSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWR 177
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 178 SAFVVAGVLGVIALAVQLLTVP-SLPPAGAPGLSTMFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEDVPQLGVEA 256
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPeSRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 257 ISLVLLIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFITRV 336
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
330
....*....|....*..
gi 549800291 337 ASDEAESAGALLLTTFQ 353
Cdd:COG2814 325 APPEARGRASGLYNSAF 341
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
25-369 |
1.17e-23 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 101.32 E-value: 1.17e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 25 VVSLSLGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIISSTL 104
Cdd:PRK10091 5 ILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 105 AAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAG 184
Cdd:PRK10091 85 FTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 185 VLGVIALAVQLLTVPSLPPAGAPGLSTMFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEDVPQLGVEAISLVLLIY 264
Cdd:PRK10091 165 VFNIAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFIMMLV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 265 GIGGFFGNLFGGFLAEKNTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFA-FGALPVSVQSFITRVASDEAES 343
Cdd:PRK10091 245 GLGMVLGNLLSGRLSGRYSPLRIAAVTDFIIVLALLMLFFFGGMKTASLIFAFICCAgLFALSAPLQILLLQNAKGGELL 324
|
330 340
....*....|....*....|....*.
gi 549800291 344 AGALLLTTFQIAISSGAVLGGLLIDL 369
Cdd:PRK10091 325 GAAGGQIAFNLGSAIGAYCGGMMLTL 350
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-391 |
5.01e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 84.54 E-value: 5.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 21 KWAAVVSLSLGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLII 100
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 101 SSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAF 180
Cdd:COG2271 88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 181 VVAGVLGVIALAVQLLTVpslppagapglstmfrllqrtqvrigLLTTLFIVAGHFAGFTYVRPFLEDVPQLGVEAISLV 260
Cdd:COG2271 168 LILGLPGLLLALLRFWLL--------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 261 LLIYGIGGFFGNLFGGFLAEK--NTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFITRVAS 338
Cdd:COG2271 222 LSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 549800291 339 DEAE-SAGALLLTTFQIAISSGAVLGGLLIDLQGATMVFVFVAIAALLGASLMA 391
Cdd:COG2271 302 KKARgTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
28-394 |
7.22e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 84.55 E-value: 7.22e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 28 LSLGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIISSTLAAF 107
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 108 ANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAGVLG 187
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 188 VIALAVQLLTVP---SLPPAGAPGLSTMFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFL----EDVPQLGVEAISLV 260
Cdd:cd17325 161 LLALVLALLLLPeprPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLplyaAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 261 LLIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFITRVASDE 340
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 549800291 341 A-ESAGALLLTTFQIAISSGAVLGGLLIDLQGATMVFVFVAIAALLGASLMASRR 394
Cdd:cd17325 321 GrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
28-390 |
3.21e-16 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 79.56 E-value: 3.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 28 LSLGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIISSTLAAF 107
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 108 ANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAGVLG 187
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 188 VIALAVQLL--TVPSLPPAGAPGLSTMFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEdvpQLGVEAISLVLLIYG 265
Cdd:cd17489 161 LLALLLVFLvkDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAA---ERGISNAGLFFTVYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 266 IGGFFGNLFGGFLAEK-NTAWAVTFAATLIAASASILVIAGaSPVVAGLAIASWGFAFGALPVSVQS-FITRVASDEAES 343
Cdd:cd17489 238 IALLLSRPFSGKLSDRkGPKTVIIPGLLLLALGLLLLSFAG-SPWMLLLAAVLYGLGFGLLFPALQAlAVDLVPPHRRGA 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 549800291 344 AGALLLTTFQIAISSGAVLGGLLIDLQGATMVFVFVAIAALLGASLM 390
Cdd:cd17489 317 ANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
40-360 |
1.46e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 77.07 E-value: 1.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 40 FLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIISSTLAAFANGLFMLFASRV 119
Cdd:pfam07690 14 LLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 120 LLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAGVLGVIALAVQLLTVP 199
Cdd:pfam07690 94 LQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 200 SLPPAGAPGLSTMFRLL------QRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEDVPQLGVEAISLVLLIYGIGGFFGNL 273
Cdd:pfam07690 174 PPESKRPKPAEEARLSLivawkaLLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 274 FGGFLAEK---NTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFITRVAS-DEAESAGALLL 349
Cdd:pfam07690 254 LLGRLSDRlgrRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPkEERGTASGLYN 333
|
330
....*....|.
gi 549800291 350 TTFQIAISSGA 360
Cdd:pfam07690 334 TAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
21-403 |
5.25e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 76.07 E-value: 5.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 21 KWAAVVSLSLGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLII 100
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 101 SSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAF 180
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 181 VVAGVLGVIALAVQLLTVPSLPP----AGAPGLSTMFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEDVPQLGVEA 256
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAgaaaAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAAT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 257 ISLVLLIYGIGGFFGNLFGGFLAEKNTAWAVTFAA-TLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFI-T 334
Cdd:COG2223 243 AGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVfALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVpD 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 335 RVASDEAESAGALLLTTFQIAISSGAVLGGLLIDLQGA-TMVFVFVAIAALLGASLMASRRGVVPQVEAS 403
Cdd:COG2223 323 IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
43-389 |
2.08e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 74.14 E-value: 2.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 43 VSLLTPLSADLSISSGIAGQSITVTALVAAVAGP--GVVIGTRGidRRWTLLGLTTLLIISSTLAAFANGLFMLFASRVL 120
Cdd:cd17474 19 DPILPAIAEALGASPAQVGLLITAFTLPAAVLMPvaGVLADRFG--RKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 121 LGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGAtLGWRSAFVVAGVLGVIALAVQLLTVPS 200
Cdd:cd17474 97 QGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLAILFLLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 201 LPPAGAPGLSTMFRLLQRTQVRIGLLTTLFIVA----GHFAGFTYVRPFLEDVPQLGVEAISLVLLIYGIGGFFGNLFGG 276
Cdd:cd17474 176 PKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFlyffLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 277 -FLAEKNTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFITRVASDEAES-AGALLLTTFQI 354
Cdd:cd17474 256 rLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGtASSLYNFVRFL 335
|
330 340 350
....*....|....*....|....*....|....*
gi 549800291 355 AISSGAVLGGLLIDLQGATMVFVFVAIAALLGASL 389
Cdd:cd17474 336 GQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
12-396 |
5.32e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 69.90 E-value: 5.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 12 TPRRHEPDAKWAAVVSLSLGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTL 91
Cdd:COG2807 7 SARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 92 LGLTTLLIISSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPiEKMPRAMAIILTGVSVATVCAAPVGAWIG 171
Cdd:COG2807 87 LLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 172 ATLGWRSAFVVAGVLGVIALAVQLLTVPSLPPA--GAPGLSTMFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEDV 249
Cdd:COG2807 166 AALGWRGALAVWALLALLALLLWLPLLRRRPAAaaAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 250 pQLGVEAISLVLLIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSV 329
Cdd:COG2807 246 -GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLA 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 549800291 330 QSFITRVASDEAESA--GALLLTTFQIAISSGAVLGGLLIDLQG---ATMVFVFVAIAALLGASLMASRRGV 396
Cdd:COG2807 325 LTLIGLRARTPAEAAalSGMAQSVGYLLAALGPLLVGALHDATGswtAALLLLAALAVLMLVAGLLAGRPYV 396
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
28-387 |
9.48e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 68.99 E-value: 9.48e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 28 LSLGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIISSTLAAF 107
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 108 ANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWI--GATLGWRSAFVVAGV 185
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 186 LGVIALAVQLLTVPSLPPAGAPG---------LSTMFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEDVPQLGVEA 256
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKneeassksvLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 257 ISLVLLIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLI-AASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFITR 335
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLlMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 549800291 336 VASDEAESAGALLLTTFQI--AISSGAVLGGLLIDLQGATMVFVFVAIAALLGA 387
Cdd:cd06174 321 LFPPEIRGTAFGLLNTFGFlgGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAA 374
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
46-372 |
8.81e-12 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 66.06 E-value: 8.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 46 LTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIISSTLAAFANGLFMLFASRVLLGIGL 125
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 126 GGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAGVLGVIAlavqLLTVPSLPpag 205
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILA----LLLAPLLD--- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 206 apglstmFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEDVPQLGVEAISLVLLIYGIGGFFGNLFGGFLAEK-NTA 284
Cdd:cd17503 172 -------LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKfGPR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 285 WAVTFAATLIAASASIL----VIAGASPVVAGLAIASWGFAFGALPVSVQSFITrVASDEAESAGALLLTTFQIAISSGA 360
Cdd:cd17503 245 LLLLAGLLLLALGTLLLafltPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNS-LPPEQIGDATALFNTIRQLGGSIGT 323
|
330
....*....|..
gi 549800291 361 VLGGLLIDLQGA 372
Cdd:cd17503 324 ALLATLLTNRTQ 335
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
68-199 |
2.18e-10 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 58.43 E-value: 2.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 68 ALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIISSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPR 147
Cdd:TIGR00880 8 ALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGV 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 549800291 148 AMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAGVLGVIALAVQLLTVP 199
Cdd:TIGR00880 88 ALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
102-387 |
4.00e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 60.66 E-value: 4.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 102 STLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFV 181
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 182 VAGVLGVIALAVQLLTVPSLppagapglstmfrllqrtqvrIGLLTTLFIVAGHFAGFTYVRP-FLEDVPQLGVEAISLV 260
Cdd:cd17319 162 IEGLLGLLLAVLWWFYLRQV---------------------WGLALGYFGINYALYGLLTWLPtYLKQARGFSLKQVGLL 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 261 LLIYGIGGFFGNLFGGFLAEKNTAWA---VTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFITRVA 337
Cdd:cd17319 221 AAIPFLAGAIGMILGGRLSDRLLRGArrlVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLL 300
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 549800291 338 SDE-AESAGALLLTTFQIAISSGAVLGGLLIDLQGA-TMVFVFVAIAALLGA 387
Cdd:cd17319 301 PGEaAATAGGLINSGGNLGGFVAPLLIGYLVDATGSyTAAFLFLAAVALLAA 352
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
21-385 |
4.17e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 61.02 E-value: 4.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 21 KWAAVVSLSLGVFGLVTAefLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLII 100
Cdd:COG0738 8 RALIAIYLLFFLWGFATA--LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 101 SSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRaMAIILTGVSVATVCAAPVGAWI---GATLGWR 177
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLillGLSLSWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 178 SAFVVAGVLGVIALAVQLLT----VPSLPPAGAPGLSTMFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEDVPQLG 253
Cdd:COG0738 165 LPYLILAVLLLLLALLFLRSklpeIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 254 VEAISLVLLIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFI 333
Cdd:COG0738 245 EATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLA 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 549800291 334 TRVASDEAESAGALLLTTFQIAISSGAVLGGLLIDLQGATMVFVFVAIAALL 385
Cdd:COG0738 325 LDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLL 376
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
99-367 |
1.83e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 58.72 E-value: 1.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 99 IISSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRS 178
Cdd:cd17321 72 GLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRW 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 179 AFVVAGVLGVIALAvqlltvpslppagapgLSTMFRLlqrtqvriGLLTTLFIVAGHFAGFTYVRPFLEDVPQLGVEAIS 258
Cdd:cd17321 152 IFLINVPIGLVALL----------------LARTFSG--------AVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAG 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 259 LVLLIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLIAASASIL-----VIAGASPVVAGLAIASWGFAFGALPVSVQSfI 333
Cdd:cd17321 208 LALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLlallgADSSVWLLLPGLVLLGLGLGLFATPLTNAA-L 286
|
250 260 270
....*....|....*....|....*....|....
gi 549800291 334 TRVASDEAESAGALLLTTFQIAISSGAVLGGLLI 367
Cdd:cd17321 287 SSVPKEKAGAASGILNTARQLGGALGVALLGALL 320
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
99-390 |
2.01e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 58.74 E-value: 2.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 99 IISSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRS 178
Cdd:cd17320 75 ILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRA 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 179 AFVVAGVLGVIALAVQLLTVPSLPPAGAPG------LSTMFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEDVPQL 252
Cdd:cd17320 155 IFVFLALLGLLLLLLVLLFLPETLPEEKRKpllsslLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGL 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 253 GVEAISLVLLIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLIAASASILVIAGAS-------PVVAGLAIASwgFAFGAL 325
Cdd:cd17320 235 SPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALlgglslwPLVAPLFLIF--FGFGLI 312
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 549800291 326 PVSVQSFITRVASDEAESAGALLLTTFQIAISSGAVLGGLLIDLQGATMVFVFVAIAALLGASLM 390
Cdd:cd17320 313 FPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLI 377
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
99-385 |
2.10e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 58.77 E-value: 2.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 99 IISSTLAAFANGLFMLFASRVLLGIGlggfwAMSA---ALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLG 175
Cdd:cd17472 73 IAGSLLAAYATSIYGLILGRALQGSG-----AISSvvmALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 176 WRSAFVVAGVLGVIALAVQLLTVPSLPPAGAPGLSTMFRLLQRTQVRIGLLTTLFIVAGHFA--GFTYVRPFLEDVPQLG 253
Cdd:cd17472 148 VSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVlmAFFYILPLLLTQLGGG 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 254 VEAISLVLLIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGF--AFGALPVSVQS 331
Cdd:cd17472 228 KGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFfiGFNLLEALLPS 307
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 549800291 332 FITRVASDEAESAGALLLTTFQ-IAISSGAVLGGLLIDLQGATMVFVFVAIAALL 385
Cdd:cd17472 308 LVSKIAPKEYRGTAMGIYNTSQfLGSFLGGALGGLLWGLLGYSSVFLTILILALL 362
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
39-199 |
4.82e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 57.63 E-value: 4.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 39 EFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPgvVIGTRG--IDRRWTLLGLTTLLIISSTLAAFANGLFMLFA 116
Cdd:cd17328 15 RFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSP--IFGYLGdrYNRKWILAVGILIWSAATLLSSFAPNFWQLLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 117 SRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIG-ATLGWRSAFVVAGVLGVIALAVQL 195
Cdd:cd17328 93 FRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGWRWAFRVTGVLGVLLAILLL 172
|
....
gi 549800291 196 LTVP 199
Cdd:cd17328 173 LFVR 176
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
24-204 |
6.57e-09 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 57.39 E-value: 6.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 24 AVVSLSLGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIISST 103
Cdd:TIGR00711 3 LTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 104 LAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVA 183
Cdd:TIGR00711 83 LCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLIN 162
|
170 180
....*....|....*....|.
gi 549800291 184 GVLGVIALAVQLLTVPSLPPA 204
Cdd:TIGR00711 163 VPIGIIVVVVAFFILPRDKPA 183
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
49-394 |
4.19e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 54.54 E-value: 4.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 49 LSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIISSTLAAFANGLFMLFASRVLLGIGLGGF 128
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 129 WAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIgATLGWRSAFVVAGVLGVIALAVQLLTVP-----SLPP 203
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLFLAAAVLFLLAALVLLFLLPetrpkRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 204 AGAPGLSTMFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEDVPQLGVEAISLVLLIYGIGGFFGNLFGGFLAEKNT 283
Cdd:cd17329 185 EKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 284 AWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFITRVASDEAE-SAGALLLTTFQIAISSGAVL 362
Cdd:cd17329 265 LRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRgSYMGFYALAWGLGRAIGPLV 344
|
330 340 350
....*....|....*....|....*....|..
gi 549800291 363 GGLLIDLQGATMVFVFVAIAALLGASLMASRR 394
Cdd:cd17329 345 GGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
49-368 |
4.30e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 54.51 E-value: 4.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 49 LSADLSISSGIAGQSITVTALVAAVAGPgvVIGTRG--IDRRWTLLGLTTLLIISSTLAAFANGLFMLFASRVLLGIGLG 126
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTP--ILGRLGdlYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 127 GFwAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAGVLGVIALAVqlltVPSLPPaga 206
Cdd:cd17504 100 VF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL----VPLIDL--- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 207 pglstmfRLLQRTQVRIGLLTTLFIVAGHFAGFtYVRPFLEDVPQ-----LGVEAISLVLLIYGIGGFFGNLFGGFLAEK 281
Cdd:cd17504 172 -------RLLRRRNVLLANITALLAGFGMFMVF-QLLPQLLQLPTptgfgLGITEAGLLLLPGALVMLIAGPLAGRLIAR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 282 NTA-WAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFITRVAS-DEAESAGALLLTTFQIAISSG 359
Cdd:cd17504 244 VGPrRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPpDRTGIATGMNTVLRTIGSAIG 323
|
....*....
gi 549800291 360 AVLGGLLID 368
Cdd:cd17504 324 PAIAGAILT 332
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
21-304 |
9.67e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 53.28 E-value: 9.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 21 KWAAVVSLSLGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLII 100
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 101 SSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAF 180
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 181 VVAGVLGVIALAVQLLTVPSLPPAGAPGLSTMFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEDVPQLGVEAISLV 260
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 549800291 261 LLIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLIAASASILVIA 304
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
63-391 |
1.44e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 53.01 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 63 SITVTALVAAVAGPGVVIGT----RGIDR---RWTLLGLTTLLIISSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAAL 135
Cdd:cd17475 29 SLAQVGLLLSALNLGVAVSMlpagWLLDRfgeRRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 136 ALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAGVLGVIALAVQLL------TVPSLPPAGAPGL 209
Cdd:cd17475 109 IMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLfyreppAASAATESASTLL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 210 STMFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEDVPQLGVEAISLVLLIYGIGGFFGNLFGGFLAEKNTA----- 284
Cdd:cd17475 189 RSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGgrrrp 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 285 --WAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFITRVASDEAESAGALLLTTFQIAISSGAVL 362
Cdd:cd17475 269 vlVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPL 348
|
330 340 350
....*....|....*....|....*....|
gi 549800291 363 GGLLIDLQGA-TMVFVFVAIAALLGASLMA 391
Cdd:cd17475 349 FGLLVDATHSyAPAWLALALLLVLAALLLL 378
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
99-390 |
1.63e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 52.99 E-value: 1.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 99 IISSTLAAFANGLFMLFASRVLLGIGlGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRS 178
Cdd:cd17490 73 VLASLIMILFPSPWGLLIARFLSGIA-AATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRA 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 179 AFVVAGVLGVIALAVQLLTVPSLPPA--GAPGLSTMFRLLqrTQVRIGLLTTLFIVAgHFAGFTYVRPFLEDVP-QLGVE 255
Cdd:cd17490 152 PFLLAALAGVLGFILSLFIKEERREKkpVLTELKELLSVL--KDKKLLFFSLLAILQ-QMITFSTTFGFTPLIAkQLGAS 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 256 AISLVLL--IYGIGGFFGNLFGGFLAEK--NTAWAVTFAATLIAASASILVIAGASPVVAGLAIASwGFAFGAL-PVSVQ 330
Cdd:cd17490 229 SFQLGLLsiIYLLPNALASLLSGTLFYKklGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALN-GFGTGILfPLLMS 307
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 331 SFITRVASDEAESAGALLLTTFQIAISSGAVLGGLLIDLQGATMVFVFVAIAALLGASLM 390
Cdd:cd17490 308 LSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILS 367
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
102-394 |
2.41e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 52.20 E-value: 2.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 102 STLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFV 181
Cdd:cd17365 78 TLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFL 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 182 VAGVLGVIALAVQLLTvpslppagapglstmfrllqrtqvrIGLLTTLFIVAGHFAGFTYVRPFLEDVPQLGVEAISLVL 261
Cdd:cd17365 158 LGGVPPLILLPLLRGT-------------------------LLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTIT 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 262 LIYGIGGFFGNLFGGFLAEK-NTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFITRVASDE 340
Cdd:cd17365 213 LLLNIGGVIGSLLLGWLADRfGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTE 292
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 549800291 341 AESAG-ALLLTTFQIAISSGAVLGGLLIDLQ-GATMVFVFVAIAALLGASLMASRR 394
Cdd:cd17365 293 VRATGvGWALGVGRLGAILGPLLGGLLLAAGlGPESVFLALAIPAALGALAVLLLR 348
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
87-391 |
3.79e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.45 E-value: 3.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 87 RRWTLLGLTTLLIISSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPV 166
Cdd:cd17316 65 RKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALV 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 167 GAWI----GATLGWRSAFVVAGVLGVIALAVQLLTVpslppagapglstmfrllqrtqvrIGLLTTLFIVAGHFAGFTYV 242
Cdd:cd17316 145 ASLLipllSGDWGWRILFLIGALPALLALLLRRRTL------------------------LLILLWFFISFGYYGLTTFL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 243 RPFLEDVPQLGVEAISLVLLIYGIGGFFGNLFGGFLAEK-NTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFA 321
Cdd:cd17316 201 PTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRiGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSF 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 549800291 322 FGALPVSVQ-SFITRVASDEAESAGALLLTTFQIAISSGA-VLGGLLIDLQGATMVFVFVAIAALLGASLMA 391
Cdd:cd17316 281 FVGGVWGALyAYLAELFPTEVRATGVGLSYNLGRLGGGGApPLIALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
21-391 |
6.34e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 51.12 E-value: 6.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 21 KWAAVVSLSLGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGP--GVVIGTRGIdrRWTLLGLTTLL 98
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPfvGRLLDRFGP--RRVMLLGLLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 99 IISSTLAAFANGLFMLFASRVLL-GIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWR 177
Cdd:cd17355 79 AAGLVLLALATSLWQLYLLWGLLgGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 178 SAFVV-AGVLGVIALAVQLLTVPSLPPAGAPGLSTMFRLLQRTQVRIG--------LLTTLFIVAGHFAGFTYVRPFLED 248
Cdd:cd17355 159 TALLVlALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEAlrsasfwlLALAFFLCGFAVVGLIVHLVPYLA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 249 VPQLGVEAISLVLLIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLI-AASASILVIAGASPVVAGLAIASWGFAFGA-LP 326
Cdd:cd17355 239 DRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALrALGLALLLLLPFPPLALLLFAALFGLGWGAtVP 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 549800291 327 VSVQSFITRVASDEAESAGALLLTTFQIAISSGAVLGGLLIDLQGATMVFVFVAIAALLGASLMA 391
Cdd:cd17355 319 LTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLV 383
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
45-195 |
8.99e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 50.76 E-value: 8.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 45 LLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIISSTLAAFANGLFMLFASRVLLGIG 124
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLG 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 549800291 125 LGGFWAMSAALALRLVPIEKMPRAMAIILTGVSV----ATVCAAPVGAWIGATLGWRSAFVVAGVLGVIALAVQL 195
Cdd:cd17371 101 FGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVgwllATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRR 175
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
64-394 |
1.11e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 50.26 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 64 ITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIISSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIE 143
Cdd:cd17473 41 LTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 144 KMPRAMAIILTGVSVATVCAAPVGAWIgATLGWRSAFVVAGVLGVIALAVQLL---TVPSLPPAGAPGLSTMFRLLQRTQ 220
Cdd:cd17473 121 ERAKMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFLVYLLALPVLILVLLFlpePARKSKSAASPGAATAAALPWKRV 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 221 VRIGLLTTLFIVAgHFAGFTYVRPFLEDVPQLGVEAISLVLLIYGIGGFFGNLFGGFLAeKNTAWAVTFAATLIAASASI 300
Cdd:cd17473 200 LPIYFLAFLAMLL-FYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLK-RRLGKRRLLAIGFALMALGF 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 301 LVIAGAS-PVVAGLAIASWGFAFGALPVSVQSFITRVASDEAESAGALLLTTFQI--AISSGAVLGGLLIDLQGATMVFV 377
Cdd:cd17473 278 LLLALASgLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFlgQFLSPLVLGPLVNLTGGLSGAFL 357
|
330
....*....|....*..
gi 549800291 378 FVAIAALLGASLMASRR 394
Cdd:cd17473 358 ILGVLALVLAIVLLLLR 374
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
43-390 |
1.03e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 47.19 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 43 VSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIISSTLAAFANGLFMLFASRVLLG 122
Cdd:cd17330 19 LPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 123 IGLGGFWAMSAALAlRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAGVLGVIALAVQLLTVPSLP 202
Cdd:cd17330 99 LTGGNVSVAQAYIA-DITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 203 pagapglstmfrllqrtqvriGLLTTLFIVAGHFAGFTYVRP-FLEDVPQLGVEAISLVLLIYGIGGFFGNLFGGFLAEK 281
Cdd:cd17330 178 ---------------------RLLLVYFLIALAFAGLESVFSlFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 282 NTA-WAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFITRVASDEAESAGALLLTTFQ-IAISSG 359
Cdd:cd17330 237 RLGeRKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQsLARIIG 316
|
330 340 350
....*....|....*....|....*....|.
gi 549800291 360 AVLGGLLIDLQGATMVFVFVAIAALLGASLM 390
Cdd:cd17330 317 PLLAGPLYSFLGPGVPFLLAAGLLLIALFLL 347
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
103-201 |
1.11e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 47.16 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 103 TLAAFANGLFMLFASRVLLGIGLG-GFWAMSAALAlRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFV 181
Cdd:cd17380 81 TPLLAYSSLPLLILSRILLGLGEGvHFPSMTSLFS-RWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFY 159
|
90 100
....*....|....*....|
gi 549800291 182 VAGVLGVIALAVQLLTVPSL 201
Cdd:cd17380 160 FFGLLGLLWALVWLIYLPPV 179
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
110-387 |
1.30e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 110 GLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAGVLGVI 189
Cdd:cd06173 91 SLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLL 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 190 ALAVQLLTVPSLPPAGAP-------GLSTMFRLLQRTQVRIGLLTTLFIVAGHFAGFTYVRP-FLEDVPQLGVEAISLVL 261
Cdd:cd06173 171 SALLLLFIRRPPPAAPGEssslllrDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPlLAKEVLGGGAAGYGLLL 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 262 LIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFI-TRVASDE 340
Cdd:cd06173 251 AAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLqLRVPDEL 330
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 549800291 341 AESAGALLLTTFQIAISSGAVLGGLLIDLQGATMVFVFVAIAALLGA 387
Cdd:cd06173 331 RGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAA 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
22-199 |
1.64e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 46.40 E-value: 1.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 22 WAAVVSLSLGVFGLVTAEFLPVSLLTP-LSADLSISSGIAGQSITVTALVAAVAGP--GVVIGTRGIDRRWTLLGLTTLL 98
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLlgGWLSDRLGRRRKLVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 99 IISSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRS 178
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|.
gi 549800291 179 AFVVAGVLGVIALAVQLLTVP 199
Cdd:COG2271 339 AFLLLAALALLAALLALLLLR 359
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
85-193 |
2.62e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 45.63 E-value: 2.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 85 IDRRWTLLGLTTLLIISSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAA 164
Cdd:cd17502 57 FGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGP 136
|
90 100
....*....|....*....|....*....
gi 549800291 165 PVGAWIGATLGWRSAFVVAGVLGVIALAV 193
Cdd:cd17502 137 LIGGAFTDHLSWRWCFYINLPIGGLALAL 165
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
49-199 |
3.16e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 45.81 E-value: 3.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 49 LSADLSISSGIAGqSITVTALVAAVAGpGVVIGTRG--IDRRWTLLGLTTLLIISSTLAAFANGLFMLFASRVLLGIGLG 126
Cdd:TIGR00895 43 ISAEWGLDPVQLG-FLFSAGLIGMAFG-ALFFGPLAdrIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLG 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 549800291 127 GFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAGVLGVIALAVQLLTVP 199
Cdd:TIGR00895 121 GLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLP 193
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
40-389 |
3.95e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 45.24 E-value: 3.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 40 FLPVsLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIISSTLAAFANGLFMLFASRV 119
Cdd:cd17478 14 FLPA-LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 120 LLGIGLGGFWAMSAALAlRLVPIEKMPRAMAIILTGVSVATvCAAPVGAWIGATLGWRSAFVVAGVLGVIALAVQLLTVP 199
Cdd:cd17478 93 LAGIGSAAFHPEGARLA-SQAAGGRRGLAMSIFSVGGNLGF-ALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 200 SLPPAGAPGLSTMFRLLQRTQVRIGLLTTLFIVAG-----HFAGFTYVRPFLEDVpQLGVEAISLVLLIYGIGGFFGNLF 274
Cdd:cd17478 171 PLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFlrswvLSSLTTFLPFYLVQR-GYSLVFAGLLLSLFLFAGAIGTLI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 275 GGFLAEKNTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVqSFITRVASDEAESAGALLLTTFQI 354
Cdd:cd17478 250 GGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTV-VLAQELLPGNVGLASGLMMGLSFG 328
|
330 340 350
....*....|....*....|....*....|....*
gi 549800291 355 AISSGAVLGGLLIDLQGATMVFVFVAIAALLGASL 389
Cdd:cd17478 329 LGGIGAPVLGALADAFGLESVLLILALLPLLGALL 363
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
24-196 |
7.23e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 44.47 E-value: 7.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 24 AVVSLSLGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVA--GPGVVIGTRGIDRRWTLLGLTTLLIIS 101
Cdd:cd17352 184 TFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGriLLGLLADKPRIGRLYLYIFTLLILGLS 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 102 STLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWI-GATLGWRSAF 180
Cdd:cd17352 264 LLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLrDYTGDYDAAF 343
|
170
....*....|....*.
gi 549800291 181 VVAGVLGVIALAVQLL 196
Cdd:cd17352 344 YFCGACLLLSGVLLFL 359
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
100-189 |
9.01e-05 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 44.53 E-value: 9.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 100 ISSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSA 179
Cdd:PRK12307 95 VGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAA 174
|
90
....*....|
gi 549800291 180 FVVaGVLGVI 189
Cdd:PRK12307 175 FFV-GLLPVL 183
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
110-199 |
1.05e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 44.15 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 110 GLFMLFASRVLLGIGLGGFW-AMSAALALRLVPIEKMpRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAGVLGV 188
Cdd:cd17318 110 GYGALIVLRILQGLAQGVTFpAMHALWAKWAPPLERS-RLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGL 188
|
90
....*....|.
gi 549800291 189 IALAVQLLTVP 199
Cdd:cd17318 189 LWCLLWFFLVL 199
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
32-390 |
1.35e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.70 E-value: 1.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 32 VFGLVTAEFLPVSLLTPLsadLSISSGIAGQSITVTALVAAVAGPGVVIGT-------RGIDRRWTLLGLTTLLIISSTL 104
Cdd:cd17477 1 LLLSVALLGLGSGLLLPL---LSLRLEREGVSTALIGLVASAYYLGILLGSplvprliRRVGHIRAFAAGAAITAVSVLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 105 AAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVcAAPVGAWIGATLGWRsAFVVAG 184
Cdd:cd17477 78 LALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFA-LGPLLLALVGTAGAL-PFLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 185 VLGVIALAVQLLTVPSLPPAGAPGLSTMFRLLQrtQVRIGLLTTLFIVAGHFAGFTYVRPFLEDVpQLGVEAISLVLLIY 264
Cdd:cd17477 156 VLLLLALVPLLLTRRAAPEIEEAESISLRRLLR--IAPLALLGAFVAGFLEGAFYSLLPLYGLRL-GLSVAQAALLLAAF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 265 GIGGFFGNLFGGFLAEK-NTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGAL-PVSVQSFITRVASDEAE 342
Cdd:cd17477 233 VLGGLLLQWPLGWLADRfDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLyTLALALAGDRLPGDELV 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 549800291 343 SAGALLLTTFQIAISSGAVLGGLLIDLQGATMVFVFVAIAALLGASLM 390
Cdd:cd17477 313 AANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
50-387 |
1.55e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 40.33 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 50 SADLSISSGIAgqsITVTALVAAVAGPgvvIGTRGID---RRWTLLGLTTLLIISSTLAAFANGLFMLFASRVLLGIgLG 126
Cdd:cd17391 31 GGLVELWSGLA---FSSTFLVSAIFSP---IWGRLADrygRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGV-FS 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 127 GFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAGVLGVIALAVQLLTVPS--LPPA 204
Cdd:cd17391 104 GYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEdfKPVE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 205 GAPGLSTM--FRLLQRTQVRIGLLTTLFIVagHFAGFT-------YVRPFLEDVPQLGVEAiSLVLLIYGIGGFFGNLFG 275
Cdd:cd17391 184 KKKMVSTKevWNSVPNPSLLISLFVTTFII--QLANQSiepiltlYIRQLMGDASNLAFIS-GLVFSATGVSSLLSAPRL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 276 GFLAEKNTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQSFITRVASDEAESAGALLLTTFQ-I 354
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQyL 340
|
330 340 350
....*....|....*....|....*....|...
gi 549800291 355 AISSGAVLGGLLIDLQGATMVFVFVAIAALLGA 387
Cdd:cd17391 341 GNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNA 373
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
60-198 |
1.59e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.27 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 60 AGQSITVTALVAAVAGP--GVVIGTRGidRRWTLLGLTTLLIISSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALAL 137
Cdd:cd17489 229 AGLFFTVYAIALLLSRPfsGKLSDRKG--PKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAV 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 549800291 138 RLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAGVLGVIALAVQLLTV 198
Cdd:cd17489 307 DLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
88-189 |
5.48e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 38.51 E-value: 5.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 88 RWTLLGLTTLLIISSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAP-V 166
Cdd:TIGR00881 60 RVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPlV 139
|
90 100
....*....|....*....|...
gi 549800291 167 GAWIGATLGWRSAFVVAGVLGVI 189
Cdd:TIGR00881 140 LFGIAELYSWHWVFIVPGIIAII 162
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
87-196 |
6.05e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.37 E-value: 6.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 87 RRWTLLGLTTLLIISSTLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPV 166
Cdd:cd06173 273 RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALL 352
|
90 100 110
....*....|....*....|....*....|
gi 549800291 167 GAWIGATLGWRSAFVVAGVLGVIALAVQLL 196
Cdd:cd06173 353 AGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
30-193 |
7.06e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.29 E-value: 7.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 30 LGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIISSTLAAFAN 109
Cdd:cd17370 206 LLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGS 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 110 GLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAGVLGVI 189
Cdd:cd17370 286 SLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALI 365
|
....
gi 549800291 190 ALAV 193
Cdd:cd17370 366 ALLL 369
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
83-390 |
7.56e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 38.30 E-value: 7.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 83 RGIDRRWTLLGLTTLLIISSTLAAFA-NGLFMLFASRVLLGIGLGGF---WAMSAALALRlVPIEKMPRAMAIILTGVSV 158
Cdd:cd17471 58 RGGDRKPLILLALLAGALGYLLFAFLrNYWVLLLVGVVLLSLGAAAFpqlFALAREYADR-SSGRDATLFNSVLRAAFSL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 159 ATVCAAPVGAWIGATLGWRSAFVVAGVLGVIALAVQLLTVPSLPPAGAPGL--STMFRLLQRTQVRIGLLTTLFIVAGHF 236
Cdd:cd17471 137 AWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATpaSSLVKAPVNRRLLLLFAAFTLLFAANS 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 237 AGFTYVRPFLEDVPQLGVEAISLVLLIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLIAASASILVI-AGASPVVAGLAI 315
Cdd:cd17471 217 MYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLAlATSLWQLIALQL 296
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 549800291 316 ASwGFAFGALPVSVQSFITRVASDEAESAGALLLTTFQIAISSGAVLGGLLIDLQGATMVFVFVAIAALLGASLM 390
Cdd:cd17471 297 LN-AIFIGITAGLGISYFQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLL 370
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
49-240 |
7.68e-03 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 38.13 E-value: 7.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 49 LSADLSISSGIAGQSITVTALVAAVAGPGVVIGTRGIDRRWTLLGLTTLLIISSTLAAFANGLFMLFASRVLLGIGLGGF 128
Cdd:TIGR00710 31 IAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 129 WAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGATLGWRSAFVVAGVLGVIALAVQLLTVP-SLPPAGAP 207
Cdd:TIGR00710 111 SVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPeTLPYEARI 190
|
170 180 190
....*....|....*....|....*....|....*..
gi 549800291 208 GLSTMFR----LLQRTQVRIGLLTTLFIVAGHFAGFT 240
Cdd:TIGR00710 191 QISTYFEtfllLLKSKMFWGYALIYGASFGGFFAFFS 227
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
24-193 |
7.85e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.18 E-value: 7.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 24 AVVSLSLGVFGLVTAEFLPVSLLTPLSADLSISSGIAGQSITVTALVAAVAG--PGVVIGTRGIDRRWTLLGLTTLLIIS 101
Cdd:cd06174 204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGslLLGLLSDRLIGRKPLLLIGLLLMALG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 102 STLAAFANGLFMLFASRVLLGIGLGGFWAMSAALALRLVPIEKMPRAMAIILTGVSVATVCAAPVGAWIGA-TLGWRSAF 180
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAF 363
|
170
....*....|...
gi 549800291 181 VVAGVLGVIALAV 193
Cdd:cd06174 364 LVLAVLLLLAAIL 376
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
104-391 |
8.68e-03 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 38.14 E-value: 8.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 104 LAAFANGLFMLFASRVLLGiGLGgfWAMSAALALRLVPIEKMPR---AMAIILTGVSVATVCAAPVGAWIGATLGWRSAF 180
Cdd:cd17423 84 LASFATSLLHLYLCIGLLS-GLG--WALVFAPTMATVSRYFSRRrslATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 181 VVAGVLGVIALA----VQLLTVPSLPPAGAPGLSTMF--RLLQRTQVRIGLLTTLFIVAGHFAGFTYVRPFLEDVPQLGV 254
Cdd:cd17423 161 LLLSALSLHLVPcgalLRPLALPGDPPAPPRSLSAAFglSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEY 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 255 EAiSLVLLIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLIAASASILVIAGASPVVAGLAIAS--WGFAFGALPVSVQSF 332
Cdd:cd17423 241 QA-AFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAvaYGFCAGALAPLVFSV 319
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 333 ITRVASDE-AESAGALLLTTFQIAISSGAVLGGLLIDLQGATMVFVFVAIAALLGASLMA 391
Cdd:cd17423 320 LPELVGVErVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLIL 379
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
177-390 |
9.78e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 37.91 E-value: 9.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 177 RSAFVVAGVLGVIALAVQLLTVPSLPPAGAPGLSTMFRLLQR--TQVRIGLLTTLFIVAGHFAgftyvRPFL----EDVp 250
Cdd:cd17370 156 RTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKlpKAFWLYLLAVALFALGNFS-----FAFLilraQEL- 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 549800291 251 QLGVEAISLVLLIYGIGGFFGNLFGGFLAEKNTAWAVTFAATLIAASASILVIAGASPVVAGLAIASWGFAFGALPVSVQ 330
Cdd:cd17370 230 GLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIER 309
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 549800291 331 SFITRVASDEAE-SAGALLLTTFQIAISSGAVLGGLLIDLQGATMVFVFVAIAALLGASLM 390
Cdd:cd17370 310 AAVADLVPAELRgTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| |
