|
Name |
Accession |
Description |
Interval |
E-value |
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
1-267 |
0e+00 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 569.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWIENLSKDKLIPSLK 80
Cdd:PRK11172 1 MSIPAFGLGTFRLKDQVVIDSVKTALELGYRAIDTAQIYDNEAAVGQAIAESGVPRDELFITTKIWIDNLAKDKLIPSLK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 81 ESLKKLRTDYVDLTLIHWPSPGDAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKENIATNQIELSPYLQ 160
Cdd:PRK11172 81 ESLQKLRTDYVDLTLIHWPSPNDEVSVEEFMQALLEAKKQGLTREIGISNFTIALMKQAIAAVGAENIATNQIELSPYLQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 161 NRKVVDWAKQQGIHITSYMTLAYGKALKDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLD 240
Cdd:PRK11172 161 NRKVVAFAKEHGIHVTSYMTLAYGKVLKDPVIARIAAKHNATPAQVILAWAMQLGYSVIPSSTKRENLASNLLAQDLQLD 240
|
250 260
....*....|....*....|....*..
gi 550714234 241 DEDKKAIAALECNDRLVSPEGLAPNWD 267
Cdd:PRK11172 241 AEDMAAIAALDRNGRLVSPEGLAPEWD 267
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
3-250 |
3.12e-174 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 479.93 E-value: 3.12e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWIENLSKDKLIPSLKES 82
Cdd:cd19139 1 IPAFGLGTFRLKDDVVIDSVRTALELGYRHIDTAQIYDNEAAVGQAIAESGVPRDELFITTKIWIDNLSKDKLLPSLEES 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 83 LKKLRTDYVDLTLIHWPSPGDAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKENIATNQIELSPYLQNR 162
Cdd:cd19139 81 LEKLRTDYVDLTLIHWPSPNDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDEAIAVVGAGAIATNQIELSPYLQNR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 163 KVVDWAKQQGIHITSYMTLAYGKALKDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLDDE 242
Cdd:cd19139 161 KLVAHCKQHGIHVTSYMTLAYGKVLDDPVLAAIAERHGATPAQIALAWAMARGYAVIPSSTKREHLRSNLLALDLTLDAD 240
|
....*...
gi 550714234 243 DKKAIAAL 250
Cdd:cd19139 241 DMAAIAAL 248
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
1-256 |
4.93e-138 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 388.64 E-value: 4.93e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWIENLSKDKLIPSLK 80
Cdd:COG0656 3 VEIPALGLGTWQLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIAASGVPREELFVTTKVWNDNHGYDDTLAAFE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 81 ESLKKLRTDYVDLTLIHWPSPGDafsVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGkENIATNQIELSPYLQ 160
Cdd:COG0656 83 ESLERLGLDYLDLYLIHWPGPGP---YVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETG-VKPAVNQVELHPYLQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 161 NRKVVDWAKQQGIHITSYMTLAYGKALKDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLD 240
Cdd:COG0656 159 QRELLAFCREHGIVVEAYSPLGRGKLLDDPVLAEIAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELS 238
|
250
....*....|....*.
gi 550714234 241 DEDKKAIAALECNDRL 256
Cdd:COG0656 239 DEDMAAIDALDRGERL 254
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
3-247 |
8.23e-123 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 349.65 E-value: 8.23e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWIENLSKDKLIPSLKES 82
Cdd:cd19073 1 IPALGLGTWQLRGDDCANAVKEALELGYRHIDTAEIYNNEAEVGEAIAESGVPREDLFITTKVWRDHLRPEDLKKSVDRS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 83 LKKLRTDYVDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAvGKENIATNQIELSPYLQNR 162
Cdd:cd19073 81 LEKLGTDYVDLLLIHWPNP--TVPLEETLGALKELKEAGKVKSIGVSNFTIELLEEALDI-SPLPIAVNQVEFHPFLYQA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 163 KVVDWAKQQGIHITSYMTLAYGKALKDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLDDE 242
Cdd:cd19073 158 ELLEYCRENDIVITAYSPLARGEVLRDPVIQEIAEKYDKTPAQVALRWLVQKGIVVIPKASSEDHLKENLAIFDWELTSE 237
|
....*
gi 550714234 243 DKKAI 247
Cdd:cd19073 238 DVAKI 242
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
2-250 |
5.21e-111 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 320.36 E-value: 5.21e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19140 7 RIPALGLGTYPLTGEECTRAVEHALELGYRHIDTAQMYGNEAQVGEAIAASGVPRDELFLTTKVWPDNYSPDDFLASVEE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 82 SLKKLRTDYVDLTLIHWPSPGDafSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGkENIATNQIELSPYLQN 161
Cdd:cd19140 87 SLRKLRTDYVDLLLLHWPNKDV--PLAETLGALNEAQEAGLARHIGVSNFTVALLREAVELSE-APLFTNQVEYHPYLDQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 162 RKVVDWAKQQGIHITSYMTLAYGKALKDEVIARIAEKHNATAAQVILAWAI-GEGYAVIPSSTKRENLASNLLAWDLQLD 240
Cdd:cd19140 164 RKLLDAAREHGIALTAYSPLARGEVLKDPVLQEIGRKHGKTPAQVALRWLLqQEGVAAIPKATNPERLEENLDIFDFTLS 243
|
250
....*....|
gi 550714234 241 DEDKKAIAAL 250
Cdd:cd19140 244 DEEMARIAAL 253
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
3-248 |
1.45e-106 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 309.03 E-value: 1.45e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWIENLSKDKLIPSLKES 82
Cdd:cd19071 1 MPLIGLGTYKLKPEETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESGVPREELFITTKLWPTDHGYERVREALEES 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 83 LKKLRTDYVDLTLIHWPSPGDAFSVEEFM----QALLEAKEQGLTREIGISNFTIPLMEKaIAAVGKENIATNQIELSPY 158
Cdd:cd19071 81 LKDLGLDYLDLYLIHWPVPGKEGGSKEARletwRALEELVDEGLVRSIGVSNFNVEHLEE-LLAAARIKPAVNQIELHPY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 159 LQNRKVVDWAKQQGIHITSYMTLA--YGKALKDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWD 236
Cdd:cd19071 160 LQQKELVEFCKEHGIVVQAYSPLGrgRRPLLDDPVLKEIAKKYGKTPAQVLLRWALQRGVVVIPKSSNPERIKENLDVFD 239
|
250
....*....|..
gi 550714234 237 LQLDDEDKKAIA 248
Cdd:cd19071 240 FELSEEDMAAID 251
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
1-251 |
1.67e-88 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 263.08 E-value: 1.67e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWIENLSKDKLIPSLK 80
Cdd:cd19131 8 NTIPQLGLGVWQVSNDEAASAVREALEVGYRSIDTAAIYGNEEGVGKAIRASGVPREELFITTKLWNSDQGYDSTLRAFD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 81 ESLKKLRTDYVDLTLIHWPSPGDAFSVEEFmQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKENiATNQIELSPYLQ 160
Cdd:cd19131 88 ESLRKLGLDYVDLYLIHWPVPAQDKYVETW-KALIELKKEGRVKSIGVSNFTIEHLQRLIDETGVVP-VVNQIELHPRFQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 161 NRKVVDWAKQQGIHITSYMTLAYGKALKDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLD 240
Cdd:cd19131 166 QRELRAFHAKHGIQTESWSPLGQGGLLSDPVIGEIAEKHGKTPAQVVIRWHLQNGLVVIPKSVTPSRIAENFDVFDFELD 245
|
250
....*....|.
gi 550714234 241 DEDKKAIAALE 251
Cdd:cd19131 246 ADDMQAIAGLD 256
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
2-251 |
1.15e-85 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 256.04 E-value: 1.15e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19132 6 QIPAIGFGTYPLKGDEGVEAVVAALQAGYRLLDTAFNYENEGAVGEAVRRSGVPREELFVTTKLPGRHHGYEEALRTIEE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 82 SLKKLRTDYVDLTLIHWPSPGDAFSVEEFmQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGkENIATNQIELSPYLQN 161
Cdd:cd19132 86 SLYRLGLDYVDLYLIHWPNPSRDLYVEAW-QALIEAREEGLVRSIGVSNFLPEHLDRLIDETG-VTPAVNQIELHPYFPQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 162 RKVVDWAKQQGIHITSYMTLAYGKA-LKDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLD 240
Cdd:cd19132 164 AEQRAYHREHGIVTQSWSPLGRGSGlLDEPVIKAIAEKHGKTPAQVVLRWHVQLGVVPIPKSANPERQRENLAIFDFELS 243
|
250
....*....|.
gi 550714234 241 DEDKKAIAALE 251
Cdd:cd19132 244 DEDMAAIAALD 254
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
2-257 |
1.54e-85 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 257.34 E-value: 1.54e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAI----EESGVPRHELFITTKIWIENLSKDKLIP 77
Cdd:cd19123 11 LIPALGLGTWKSKPGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALaevfKEGKVKREDLWITSKLWNNSHAPEDVLP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 78 SLKESLKKLRTDYVDLTLIHWP-----------SPGDAFS-----VEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIA 141
Cdd:cd19123 91 ALEKTLADLQLDYLDLYLMHWPvalkkgvgfpeSGEDLLSlspipLEDTWRAMEELVDKGLCRHIGVSNFSVKKLEDLLA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 142 AvGKENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTLAYG------------KALKDEVIARIAEKHNATAAQVILA 209
Cdd:cd19123 171 T-ARIKPAVNQVELHPYLQQPELLAFCRDNGIHLTAYSPLGSGdrpaamkaegepVLLEDPVINKIAEKHGASPAQVLIA 249
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 550714234 210 WAIGEGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAALECNDRLV 257
Cdd:cd19123 250 WAIQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAALDRHHRYV 297
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
3-250 |
6.09e-83 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 249.03 E-value: 6.09e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVI-ASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19133 9 MPILGFGVFQIPDPEECeRAVLEAIKAGYRLIDTAAAYGNEEAVGRAIKKSGIPREELFITTKLWIQDAGYEKAKKAFER 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 82 SLKKLRTDYVDLTLIHWPSpGDafsVEEFMQALLEAKEQGLTREIGISNFTiP--LMEkaIAAVGKENIATNQIELSPYL 159
Cdd:cd19133 89 SLKRLGLDYLDLYLIHQPF-GD---VYGAWRAMEELYKEGKIRAIGVSNFY-PdrLVD--LILHNEVKPAVNQIETHPFN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 160 QNRKVVDWAKQQGIHITSYMTLAYGK--ALKDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDL 237
Cdd:cd19133 162 QQIEAVEFLKKYGVQIEAWGPFAEGRnnLFENPVLTEIAEKYGKSVAQVILRWLIQRGIVVIPKSVRPERIAENFDIFDF 241
|
250
....*....|...
gi 550714234 238 QLDDEDKKAIAAL 250
Cdd:cd19133 242 ELSDEDMEAIAAL 254
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
3-250 |
3.45e-82 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 247.55 E-value: 3.45e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKD-DVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEES----GVPRHELFITTKIWIENLSKDKLIP 77
Cdd:cd19136 1 MPILGLGTFRLRGeEEVRQAVDAALKAGYRLIDTASVYRNEADIGKALRDLlpkyGLSREDIFITSKLAPKDQGYEKARA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 78 SLKESLKKLRTDYVDLTLIHWP-----SPGDAFSVE---EFMQALLEAKEQGLTREIGISNFTIPLMEKaIAAVGKENIA 149
Cdd:cd19136 81 ACLGSLERLGTDYLDLYLIHWPgvqglKPSDPRNAElrrESWRALEDLYKEGKLRAIGVSNYTVRHLEE-LLKYCEVPPA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 150 TNQIELSPYLQNRKVVDWAKQQGIHITSYMTLAYG--KALKDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKREN 227
Cdd:cd19136 160 VNQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGSGdlRLLEDPTVLAIAKKYGRTPAQVLLRWALQQGIGVIPKSTNPER 239
|
250 260
....*....|....*....|...
gi 550714234 228 LASNLLAWDLQLDDEDKKAIAAL 250
Cdd:cd19136 240 IAENIKVFDFELSEEDMAELNAL 262
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
3-255 |
3.37e-78 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 237.29 E-value: 3.37e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDD-VVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19157 10 MPWLGLGVFKVEEGsEVVNAVKTALKNGYRSIDTAAIYGNEEGVGKGIKESGIPREELFITSKVWNADQGYDSTLKAFEA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 82 SLKKLRTDYVDLTLIHWPSPGdafSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKaIAAVGKENIATNQIELSPYLQN 161
Cdd:cd19157 90 SLERLGLDYLDLYLIHWPVKG---KYKETWKALEKLYKDGRVRAIGVSNFQVHHLED-LLADAEIVPMVNQVEFHPRLTQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 162 RKVVDWAKQQGIHITSYMTLAYGKALKDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLDD 241
Cdd:cd19157 166 KELRDYCKKQGIQLEAWSPLMQGQLLDNPVLKEIAEKYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENADVFDFELSQ 245
|
250
....*....|....
gi 550714234 242 EDKKAIAALECNDR 255
Cdd:cd19157 246 EDMDKIDALNENLR 259
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
2-257 |
4.31e-76 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 232.94 E-value: 4.31e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGTFRLKDDV-VIASVKTALELGYRAIDTAQIYDNEAAVGQA----IEESGVPRHELFITTKIWIENLSKDKLI 76
Cdd:cd19116 10 EIPAIALGTWKLKDDEgVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAirekIAEGVVKREDLFITTKLWNSYHEREQVE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 77 PSLKESLKKLRTDYVDLTLIHWP----------SPGDAFSVE----EFMQALLEAKEQGLTREIGISNFTIPLMEKaIAA 142
Cdd:cd19116 90 PALRESLKRLGLDYVDLYLIHWPvafkenndseSNGDGSLSDidylETWRGMEDLVKLGLTRSIGVSNFNSEQINR-LLS 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 143 VGKENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTLAYGKA---------LKDEVIARIAEKHNATAAQVILAWAIG 213
Cdd:cd19116 169 NCNIKPAVNQIEVHPTLTQEKLVAYCQSNGIVVMAYSPFGRLVPrgqtnppprLDDPTLVAIAKKYGKTTAQIVLRYLID 248
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 550714234 214 EGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAALECNDRLV 257
Cdd:cd19116 249 RGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNSFNTNQRVY 292
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
2-251 |
7.14e-76 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 231.34 E-value: 7.14e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19130 9 SIPQLGYGVFKVPPADTQRAVATALEVGYRHIDTAAIYGNEEGVGAAIAASGIPRDELFVTTKLWNDRHDGDEPAAAFAE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 82 SLKKLRTDYVDLTLIHWPSPGDAFSVEEFmQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKENiATNQIELSPYLQN 161
Cdd:cd19130 89 SLAKLGLDQVDLYLVHWPTPAAGNYVHTW-EAMIELRAAGRTRSIGVSNFLPPHLERIVAATGVVP-AVNQIELHPAYQQ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 162 RKVVDWAKQQGIHITSYMTLAYGKALKDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLDD 241
Cdd:cd19130 167 RTIRDWAQAHDVKIEAWSPLGQGKLLGDPPVGAIAAAHGKTPAQIVLRWHLQKGHVVFPKSVRRERMEDNLDVFDFDLTD 246
|
250
....*....|
gi 550714234 242 EDKKAIAALE 251
Cdd:cd19130 247 TEIAAIDALD 256
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
3-251 |
1.12e-74 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 228.09 E-value: 1.12e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKD-DVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19126 9 MPWLGLGVFQTPDgDETERAVQTALENGYRSIDTAAIYKNEEGVGEAIRESGVPREELFVTTKLWNDDQRARRTEDAFQE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 82 SLKKLRTDYVDLTLIHWPSPGdafSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKaIAAVGKENIATNQIELSPYLQN 161
Cdd:cd19126 89 SLDRLGLDYVDLYLIHWPGKD---KFIDTWKALEKLYASGKVKAIGVSNFQEHHLEE-LLAHADVVPAVNQVEFHPYLTQ 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 162 RKVVDWAKQQGIHITSYMTLAYGKALKDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLDD 241
Cdd:cd19126 165 KELRGYCKSKGIVVEAWSPLGQGGLLSNPVLAAIGEKYGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENADIFDFELSE 244
|
250
....*....|
gi 550714234 242 EDKKAIAALE 251
Cdd:cd19126 245 DDMTAIDALN 254
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
3-256 |
2.68e-73 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 225.34 E-value: 2.68e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWienlSKDKLIP--SLK 80
Cdd:PRK11565 15 MPQLGLGVWQASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKEASVAREELFITTKLW----NDDHKRPreALE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 81 ESLKKLRTDYVDLTLIHWPSPGDAFSVEEFmQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKENiATNQIELSPYLQ 160
Cdd:PRK11565 91 ESLKKLQLDYVDLYLMHWPVPAIDHYVEAW-KGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTP-VINQIELHPLMQ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 161 NRKVVDWAKQQGIHITSYMTLAY-GKALKD-EVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQ 238
Cdd:PRK11565 169 QRQLHAWNATHKIQTESWSPLAQgGKGVFDqKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFR 248
|
250
....*....|....*...
gi 550714234 239 LDDEDKKAIAALECNDRL 256
Cdd:PRK11565 249 LDKDELGEIAKLDQGKRL 266
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
2-247 |
1.02e-72 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 223.26 E-value: 1.02e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGTFRL---------KDDVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIEesGVPRHELFITTKIWIEN 69
Cdd:cd19072 3 EVPVLGLGTWGIgggmskdysDDKKAIEALRYAIELGINLIDTAEMYGGghaEELVGKAIK--GFDREDLFITTKVSPDH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 70 LSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKENIA 149
Cdd:cd19072 81 LKYDDVIKAAKESLKRLGTDYIDLYLIHWPNP--SIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEAQSYLKKGPIV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 150 TNQIELSpyLQNRKVVD----WAKQQGIHITSYMTLAYGKALKDE---VIARIAEKHNATAAQVILAWAIG-EGYAVIPS 221
Cdd:cd19072 159 ANQVEYN--LFDREEESgllpYCQKNGIAIIAYSPLEKGKLSNAKgspLLDEIAKKYGKTPAQIALNWLISkPNVIAIPK 236
|
250 260
....*....|....*....|....*.
gi 550714234 222 STKRENLASNLLAWDLQLDDEDKKAI 247
Cdd:cd19072 237 ASNIEHLEENAGALGWELSEEDLQRL 262
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
2-256 |
1.70e-72 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 222.81 E-value: 1.70e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19134 10 TMPVIGLGVGELSDDEAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIAASGIPRGELFVTTKLATPDQGFTASQAACRA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 82 SLKKLRTDYVDLTLIHWPSPGDAFSVEEFmQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGkENIATNQIELSPYLQN 161
Cdd:cd19134 90 SLERLGLDYVDLYLIHWPAGREGKYVDSW-GGLMKLREEGLARSIGVSNFTAEHLENLIDLTF-FTPAVNQIELHPLLNQ 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 162 RKVVDWAKQQGIHITSYMTLAYGKALKDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLDD 241
Cdd:cd19134 168 AELRKVNAQHGIVTQAYSPLGVGRLLDNPAVTAIAAAHGRTPAQVLLRWSLQLGNVVISRSSNPERIASNLDVFDFELTA 247
|
250
....*....|....*
gi 550714234 242 EDKKAIAALECNDRL 256
Cdd:cd19134 248 DHMDALDGLDDGTRF 262
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
3-250 |
2.69e-71 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 220.45 E-value: 2.69e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWieNLSKDKLIPSLKES 82
Cdd:cd19117 14 IPAVGLGTWQSKPNEVAKAVEAALKAGYRHIDTAAIYGNEEEVGQGIKDSGVPREEIFITTKLW--CTWHRRVEEALDQS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 83 LKKLRTDYVDLTLIHWPSPGDAFSVE----------------------EFMQALLEAkeqGLTREIGISNFTIPLMEKAI 140
Cdd:cd19117 92 LKKLGLDYVDLYLMHWPVPLDPDGNDflfkkddgtkdhepdwdfiktwELMQKLPAT---GKVKAIGVSNFSIKNLEKLL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 141 AAVGKENI-ATNQIELSPYLQNRKVVDWAKQQGIHITSYMTLAYGKA--LKDEVIARIAEKHNATAAQVILAWAIGEGYA 217
Cdd:cd19117 169 ASPSAKIVpAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLGSTNAplLKEPVIIKIAKKHGKTPAQVIISWGLQRGYS 248
|
250 260 270
....*....|....*....|....*....|...
gi 550714234 218 VIPSSTKRENLASNLLAWdlQLDDEDKKAIAAL 250
Cdd:cd19117 249 VLPKSVTPSRIESNFKLF--TLSDEEFKEIDEL 279
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
2-249 |
2.27e-70 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 217.49 E-value: 2.27e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGT----FRLKDDVV----IASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIW--IENLS 71
Cdd:cd19120 3 KIPAIAFGTgtawYKSGDDDIqrdlVDSVKLALKAGFRHIDTAEMYGNEKEVGEALKESGVPREDLFITTKVSpgIKDPR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 72 KdklipSLKESLKKLRTDYVDLTLIHWP--SPGDAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKaIAAVGKENIA 149
Cdd:cd19120 83 E-----ALRKSLAKLGVDYVDLYLIHSPffAKEGGPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEE-LLDTAKIKPA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 150 TNQIELSPYLQNR--KVVDWAKQQGIHITSYMTLA-----YGKALkDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSS 222
Cdd:cd19120 157 VNQIEFHPYLYPQqpALLEYCREHGIVVSAYSPLSpltrdAGGPL-DPVLEKIAEKYGVTPAQVLLRWALQKGIVVVTTS 235
|
250 260
....*....|....*....|....*..
gi 550714234 223 TKRENLASNLLAWDLQLDDEDKKAIAA 249
Cdd:cd19120 236 SKEERMKEYLEAFDFELTEEEVEEIDK 262
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
2-251 |
1.59e-69 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 216.06 E-value: 1.59e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESG----VPRHELFITTKIWIENLSKDKLIP 77
Cdd:cd19125 10 KIPAVGLGTWQADPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKKLFedgvVKREDLFITSKLWCTDHAPEDVPP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 78 SLKESLKKLRTDYVDLTLIHWP---------------SPGDAFSVEEFMQALLEAkeqGLTREIGISNFTIPLMEKaIAA 142
Cdd:cd19125 90 ALEKTLKDLQLDYLDLYLIHWPvrlkkgahmpepeevLPPDIPSTWKAMEKLVDS---GKVRAIGVSNFSVKKLED-LLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 143 VGKENIATNQIELSPYLQNRKVVDWAKQQGIHITSY-------MTLAYGKALKDEVIARIAEKHNATAAQVILAWAIGEG 215
Cdd:cd19125 166 VARVPPAVNQVECHPGWQQDKLHEFCKSKGIHLSAYsplgspgTTWVKKNVLKDPIVTKVAEKLGKTPAQVALRWGLQRG 245
|
250 260 270
....*....|....*....|....*....|....*.
gi 550714234 216 YAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAALE 251
Cdd:cd19125 246 TSVLPKSTNEERIKENIDVFDWSIPEEDFAKFSSIE 281
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
2-250 |
9.49e-69 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 213.81 E-value: 9.49e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEES-----GVPRHELFITTKIWIENLSKDKLI 76
Cdd:cd19118 6 KIPAIGLGTWQAEPGEVGAAVKIALKAGYRHLDLAKVYQNQHEVGQALKELlkeepGVKREDLFITSKLWNNSHRPEYVE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 77 PSLKESLKKLRTDYVDLTLIHWP---SPG-------------------DAFSVEEFMQALLEAKEQGLTREIGISNFTIP 134
Cdd:cd19118 86 PALDDTLKELGLDYLDLYLIHWPvafKPTgdlnpltavptnggevdldLSVSLVDTWKAMVELKKTGKVKSIGVSNFSID 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 135 LMEKAIAAVGkENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTL---AYGKAL--KDEVIARIAEKHNATAAQVILA 209
Cdd:cd19118 166 HLQAIIEETG-VVPAVNQIEAHPLLLQDELVDYCKSKNIHITAYSPLgnnLAGLPLlvQHPEVKAIAAKLGKTPAQVLIA 244
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 550714234 210 WAIGEGYAVIPSSTKRENLASNLLawDLQLDDEDKKAIAAL 250
Cdd:cd19118 245 WGIQRGHSVIPKSVTPSRIRSNFE--QVELSDDEFNAVTAL 283
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
2-250 |
6.08e-68 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 211.50 E-value: 6.08e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19127 8 EMPALGLGVFQTPPEETADAVATALADGYRLIDTAAAYGNEREVGEGIRRSGVDRSDIFVTTKLWISDYGYDKALRGFDA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 82 SLKKLRTDYVDLTLIHWPSPGDAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKENiATNQIELSPYLQN 161
Cdd:cd19127 88 SLRRLGLDYVDLYLLHWPVPNDFDRTIQAYKALEKLLAEGRVRAIGVSNFTPEHLERLIDATTVVP-AVNQVELHPYFSQ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 162 RKVVDWAKQQGIHITSYMTLA----YGKA--------LKDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKRENLA 229
Cdd:cd19127 167 KDLRAFHRRLGIVTQAWSPIGgvmrYGASgptgpgdvLQDPTITGLAEKYGKTPAQIVLRWHLQNGVSAIPKSVHPERIA 246
|
250 260
....*....|....*....|.
gi 550714234 230 SNLLAWDLQLDDEDKKAIAAL 250
Cdd:cd19127 247 ENIDIFDFALSAEDMAAIDAL 267
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
3-243 |
7.87e-68 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 211.03 E-value: 7.87e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRL---KDDVVIASVKtalELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWIENLSKDKLIPSL 79
Cdd:cd19135 13 MPILGLGTSHSggySHEAVVYALK---ECGYRHIDTAKRYGCEELLGKAIKESGVPREDLFLTTKLWPSDYGYESTKQAF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 80 KESLKKLRTDYVDLTLIHWPSPGDAF-----SVEEFMQALLEAKEQGLTREIGISNFTIP----LMEKAiaavgkeNIA- 149
Cdd:cd19135 90 EASLKRLGVDYLDLYLLHWPDCPSSGknvkeTRAETWRALEELYDEGLCRAIGVSNFLIEhleqLLEDC-------SVVp 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 150 -TNQIELSPYLQNRKVVDWAKQQGIHITSYMTLAYGKALKDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKRENL 228
Cdd:cd19135 163 hVNQVEFHPFQNPVELIEYCRDNNIVFEGYCPLAKGKALEEPTVTELAKKYQKTPAQILIRWSIQNGVVTIPKSTKEERI 242
|
250
....*....|....*
gi 550714234 229 ASNLLAWDLQLDDED 243
Cdd:cd19135 243 KENCQVFDFSLSEED 257
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
3-256 |
1.06e-66 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 209.19 E-value: 1.06e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAI----EESGVPRHELFITTKIWIENLSKDKLIPS 78
Cdd:cd19154 12 MPLIGLGTWQSKGAEGITAVRTALKAGYRLIDTAFLYQNEEAIGEALaellEEGVVKREDLFITTKLWTHEHAPEDVEEA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 79 LKESLKKLRTDYVDLTLIHWPSPG-----------------DAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEkAIA 141
Cdd:cd19154 92 LRESLKKLQLEYVDLYLIHAPAAFkddegesgtmengmsihDAVDVEDVWRGMEKVYDEGLTKAIGVSNFNNDQIQ-RIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 142 AVGKENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTLAY-GKA--------------LKDEVIARIAEKHNATAAQV 206
Cdd:cd19154 171 DNARVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLGSpGRAnftkstgvspapnlLQDPIVKAIAEKHGKTPAQV 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 550714234 207 ILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAALECNDRL 256
Cdd:cd19154 251 LLRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEEIEKSLRL 300
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
3-256 |
2.51e-65 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 204.67 E-value: 2.51e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKD-DVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESGVPRHELFITTKIWIENLSKDKLIPSLKE 81
Cdd:cd19156 9 MPRLGLGVWRVQDgAEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGIRESGVPREEVFVTTKLWNSDQGYESTLAAFEE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 82 SLKKLRTDYVDLTLIHWPSPGdafSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVgkeNIA--TNQIELSPYL 159
Cdd:cd19156 89 SLEKLGLDYVDLYLIHWPVKG---KFKDTWKAFEKLYKEKKVRAIGVSNFHEHHLEELLKSC---KVApmVNQIELHPLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 160 QNRKVVDWAKQQGIHITSYMTLAYGKALKDEVIARIAEKHNATAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQL 239
Cdd:cd19156 163 TQEPLRKFCKEKNIAVEAWSPLGQGKLLSNPVLKAIGKKYGKSAAQVIIRWDIQHGIITIPKSVHEERIQENFDVFDFEL 242
|
250
....*....|....*..
gi 550714234 240 DDEDKKAIAALECNDRL 256
Cdd:cd19156 243 TAEEIRQIDGLNTDHRY 259
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
2-251 |
5.45e-63 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 199.03 E-value: 5.45e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGT--FRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEE---SGV--PRHELFITTKIWIENLSKDK 74
Cdd:cd19124 4 TMPVIGMGTasDPPSPEDIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEalrLGLvkSRDELFVTSKLWCSDAHPDL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 75 LIPSLKESLKKLRTDYVDLTLIHWP---SPGDA---FSVEEFM--------QALLEAKEQGLTREIGISNFTIPLMEK-- 138
Cdd:cd19124 84 VLPALKKSLRNLQLEYVDLYLIHWPvslKPGKFsfpIEEEDFLpfdikgvwEAMEECQRLGLTKAIGVSNFSCKKLQEll 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 139 AIAAVGKeniATNQIELSPYLQNRKVVDWAKQQGIHITSYMTL-AYGKA------LKDEVIARIAEKHNATAAQVILAWA 211
Cdd:cd19124 164 SFATIPP---AVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLgAPGTKwgsnavMESDVLKEIAAAKGKTVAQVSLRWV 240
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 550714234 212 IGEGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAALE 251
Cdd:cd19124 241 YEQGVSLVVKSFNKERMKQNLDIFDWELTEEDLEKISEIP 280
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
3-247 |
3.66e-62 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 196.25 E-value: 3.66e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRL---------KDDVVIASVKTALELGYRAIDTAQIY---DNEAAVGQAIEEsgVPRHELFITTKIWIENL 70
Cdd:cd19137 4 IPALGLGTWGIggfltpdysRDEEMVELLKTAIELGYTHIDTAEMYgggHTEELVGKAIKD--FPREDLFIVTKVWPTNL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 71 SKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGdaFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVgKENIAT 150
Cdd:cd19137 82 RYDDLLRSLQNSLRRLDTDYIDLYLIHWPNPN--IPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAISKS-QTPIVC 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 151 NQIELSPY---LQNRKVVDWAKQQGIHITSYMTLAYGKALKDEVIARIAEKHNATAAQVILAWAIGEGYAV-IPSSTKRE 226
Cdd:cd19137 159 NQVKYNLEdrdPERDGLLEYCQKNGITVVAYSPLRRGLEKTNRTLEEIAKNYGKTIAQIALAWLIQKPNVVaIPKAGRVE 238
|
250 260
....*....|....*....|.
gi 550714234 227 NLASNLLAWDLQLDDEDKKAI 247
Cdd:cd19137 239 HLKENLKATEIKLSEEEMKLL 259
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
3-256 |
1.76e-61 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 195.41 E-value: 1.76e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAI----EESGVPRHELFITTKIWIENLSKDKLIPS 78
Cdd:cd19111 4 MPVIGLGTYQSPPEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEALkwwlKNGKLKREEVFITTKLPPVYLEFKDTEKS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 79 LKESLKKLRTDYVDLTLIHWP-----------SPGDAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKaIAAVGKEN 147
Cdd:cd19111 84 LEKSLENLKLPYVDLYLIHHPcgfvnkkdkgeRELASSDVTSVWRAMEALVSEGKVKSIGLSNFNPRQINK-ILAYAKVK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 148 IATNQIELSPYLQNRKVVDWAKQQGIHITSYMTL-AYGKA-----------LKDEVIARIAEKHNATAAQVILAWAIGEG 215
Cdd:cd19111 163 PSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLgSPGRAnqslwpdqpdlLEDPTVLAIAKELDKTPAQVLLRFVLQRG 242
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 550714234 216 YAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAALECNDRL 256
Cdd:cd19111 243 TGVLPKSTNKERIEENFEVFDFELTEEHFKKLKTLDRNMKY 283
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
1-247 |
5.76e-60 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 190.92 E-value: 5.76e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTFRLKDDV-----VIASVKTALELGYRAIDTAQIYDN---EAAVGQAIEESgvpRHELFITTKIWIENLSK 72
Cdd:cd19138 9 TKVPALGQGTWYMGEDPakraqEIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRGR---RDKVFLVSKVLPSNASR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 73 DKLIPSLKESLKKLRTDYVDLTLIHWPSpgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKENIATNQ 152
Cdd:cd19138 86 QGTVRACERSLRRLGTDYLDLYLLHWRG---GVPLAETVAAMEELKKEGKIRAWGVSNFDTDDMEELWAVPGGGNCAANQ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 153 IELSpyLQNR----KVVDWAKQQGIHITSYMTLAYG-----KALKDEVIARIAEKHNATAAQVILAWAIGEGYAV-IPSS 222
Cdd:cd19138 163 VLYN--LGSRgieyDLLPWCREHGVPVMAYSPLAQGgllrrGLLENPTLKEIAARHGATPAQVALAWVLRDGNVIaIPKS 240
|
250 260
....*....|....*....|....*
gi 550714234 223 TKRENLASNLLAWDLQLDDEDKKAI 247
Cdd:cd19138 241 GSPEHARENAAAADLELTEEDLAEL 265
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
3-260 |
1.26e-59 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 191.23 E-value: 1.26e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVG----QAIEESGVPRHELFITTKIWIENLSKDKLIPS 78
Cdd:cd19114 4 MPLVGFGTAKIKANETEEVIYNAIKVGYRLIDGALLYGNEAEVGrgirKAIQEGLVKREDLFIVTKLWNNFHGKDHVREA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 79 LKESLKKLRTDYVDLTLIHWPSP----------------GDAFS-------VEEFMQALLEAKEQGLTREIGISNFTIPL 135
Cdd:cd19114 84 FDRQLKDYGLDYIDLYLIHFPIPaayvdpaenypflwkdKELKKfpleqspMQECWREMEKLVDAGLVRNIGIANFNVQL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 136 MEKAIAaVGKENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTLA-------------YGKALKDEVIARIAEKHNAT 202
Cdd:cd19114 164 ILDLLT-YAKIKPAVLQIEHHPYLQQKRLIDWAKKQGIQITAYSSFGnavytkvtkhlkhFTNLLEHPVVKKLADKHKRD 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 550714234 203 AAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAALECNDRLVSPE 260
Cdd:cd19114 243 TGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEALYELEANARFNDPV 300
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
2-259 |
2.01e-59 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 190.67 E-value: 2.01e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEES-----GVPRHELFITTKIWIENLSKDKLI 76
Cdd:cd19106 6 KMPLIGLGTWKSKPGQVKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKvgpgkAVPREDLFVTSKLWNTKHHPEDVE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 77 PSLKESLKKLRTDYVDLTLIHWP---SPGD--------------AFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKa 139
Cdd:cd19106 86 PALRKTLKDLQLDYLDLYLIHWPyafERGDnpfpknpdgtirydSTHYKETWKAMEKLVDKGLVKAIGLSNFNSRQIDD- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 140 IAAVGKENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTL-----AYGKA-----LKDEVIARIAEKHNATAAQVILA 209
Cdd:cd19106 165 ILSVARIKPAVLQVECHPYLAQNELIAHCKARGLVVTAYSPLgspdrPWAKPdepvlLEEPKVKALAKKYNKSPAQILLR 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 550714234 210 WAIGEGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAALECNDRLVSP 259
Cdd:cd19106 245 WQVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDALNRNWRYIVP 294
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
3-260 |
1.28e-57 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 186.15 E-value: 1.28e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEESG----VPRHELFITTKIWieNLSKDKLIPS 78
Cdd:cd19112 11 MPVIGLGVWRMEPGEIKELILNAIKIGYRHFDCAADYKNEKEVGEALAEAFktglVKREDLFITTKLW--NSDHGHVIEA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 79 LKESLKKLRTDYVDLTLIHWP---------SPGDAF------------SVEEFMQALLEAKEQGLTREIGISNFTIPLMe 137
Cdd:cd19112 89 CKDSLKKLQLDYLDLYLVHFPvatkhtgvgTTGSALgedgvldidvtiSLETTWHAMEKLVSAGLVRSIGISNYDIFLT- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 138 KAIAAVGKENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTLAYGKA----------LKDEVIARIAEKHNATAAQVI 207
Cdd:cd19112 168 RDCLAYSKIKPAVNQIETHPYFQRDSLVKFCQKHGISVTAHTPLGGAAAnaewfgsvspLDDPVLKDLAKKYGKSAAQIV 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 550714234 208 LAWAIGEGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAALECNDRLVSPE 260
Cdd:cd19112 248 LRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSLDRKYRTNQPA 300
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
3-247 |
2.32e-57 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 184.66 E-value: 2.32e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEES---GVPRHELFITTKIWieNLSKDKLIPSL 79
Cdd:cd19121 12 IPAVGLGTWQAKAGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAiagGVKREDLFVTTKLW--STYHRRVELCL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 80 KESLKKLRTDYVDLTLIHWPSPGDAFSVEEFMQALLEAK--------------------EQGLTREIGISNFTIPLMEKA 139
Cdd:cd19121 90 DRSLKSLGLDYVDLYLVHWPVLLNPNGNHDLFPTLPDGSrdldwdwnhvdtwkqmekvlKTGKTKAIGVSNYSIPYLEEL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 140 IAAvGKENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTL--AYGKALKDEVIARIAEKHNATAAQVILAWAIGEGYA 217
Cdd:cd19121 170 LKH-ATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPLgsTGSPLISDEPVVEIAKKHNVGPGTVLISYQVARGAV 248
|
250 260 270
....*....|....*....|....*....|
gi 550714234 218 VIPSSTKRENLASNLLAWDlqLDDEDKKAI 247
Cdd:cd19121 249 VLPKSVTPDRIKSNLEIID--LDDEDMNKL 276
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
3-267 |
1.23e-56 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 183.80 E-value: 1.23e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQ----AIEESGVPRHELFITTKIWIENLSKDKLIPS 78
Cdd:cd19113 11 MPSVGFGCWKLDNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEgvnrAIDEGLVKREELFLTSKLWNNFHDPKNVETA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 79 LKESLKKLRTDYVDLTLIHWP------------------SPGDAFSVE-----EFMQALLEAKEQGLTREIGISNFTIPL 135
Cdd:cd19113 91 LNKTLSDLKLDYVDLFLIHFPiafkfvpieekyppgfycGDGDNFVYEdvpilDTWKALEKLVDAGKIKSIGVSNFPGAL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 136 MEKAIAAVgKENIATNQIELSPYLQNRKVVDWAKQQGIHITSY--------MTLAYGKAL------KDEVIARIAEKHNA 201
Cdd:cd19113 171 ILDLLRGA-TIKPAVLQIEHHPYLQQPKLIEYAQKAGITITAYssfgpqsfVELNQGRALntptlfEHDTIKSIAAKHNK 249
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550714234 202 TAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAALECNDRLVSPeglapnWD 267
Cdd:cd19113 250 TPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFEEIAKLDIGLRFNDP------WD 309
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
4-250 |
3.74e-54 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 176.17 E-value: 3.74e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 4 PALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEE----SGVPRHELFITTKIWIENLSKDKLIPSL 79
Cdd:cd19128 2 PRLGFGTYKITESESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEifkdGGVKREDLFITSKLWPTMHQPENVKEQL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 80 KESLKKLRTDYVDLTLIHWP------SPGDAFSVEEF-------MQALLEAKEQ----GLTREIGISNFTIPLMEKAIaA 142
Cdd:cd19128 82 LITLQDLQLEYLDLFLIHWPlafdmdTDGDPRDDNQIqslskkpLEDTWRAMEQcvdeKLTKNIGVSNYSTKLLTDLL-N 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 143 VGKENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTL----AYGKA--LKDEVIARIAEKHNATAAQVILAWAIGE-- 214
Cdd:cd19128 161 YCKIKPFMNQIECHPYFQNDKLIKFCIENNIHVTAYRPLggsyGDGNLtfLNDSELKALATKYNTTPPQVIIAWHLQKwp 240
|
250 260 270
....*....|....*....|....*....|....*..
gi 550714234 215 -GYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAAL 250
Cdd:cd19128 241 kNYSVIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
6-250 |
7.09e-54 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 175.96 E-value: 7.09e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 6 LGLGTFRLK-------DDVVIASVKTALELGYRAIDTAQIYD---NEAAVGQAIEESGVPRHELFITTKI------WIEN 69
Cdd:pfam00248 1 IGLGTWQLGggwgpisKEEALEALRAALEAGINFIDTAEVYGdgkSEELLGEALKDYPVKRDKVVIATKVpdgdgpWPSG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 70 LSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAvGKENIA 149
Cdd:pfam00248 81 GSKENIRKSLEESLKRLGTDYIDLYYLHWPDP--DTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALTK-GKIPIV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 150 TNQIELSPY--LQNRKVVDWAKQQGIHITSYMTLAYGKALK---------------------------DEVIARIAEKHN 200
Cdd:pfam00248 158 AVQVEYNLLrrRQEEELLEYCKKNGIPLIAYSPLGGGLLTGkytrdpdkgpgerrrllkkgtplnleaLEALEEIAKEHG 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 550714234 201 ATAAQVILAWAIGE--GYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAAL 250
Cdd:pfam00248 238 VSPAQVALRWALSKpgVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDEL 289
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
3-255 |
1.05e-53 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 176.07 E-value: 1.05e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIE----ESGVPRHELFITTKIWIENLSKDKLIPS 78
Cdd:cd19107 4 MPILGLGTWKSPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQekikEQVVKREDLFIVSKLWCTFHEKGLVKGA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 79 LKESLKKLRTDYVDLTLIHWPS---PGDAF-----------SVEEFMQ---ALLEAKEQGLTREIGISNFTIPLMEKAIA 141
Cdd:cd19107 84 CQKTLSDLKLDYLDLYLIHWPTgfkPGKELfpldesgnvipSDTTFLDtweAMEELVDEGLVKAIGVSNFNHLQIERILN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 142 AVG-KENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTLA-----YGKA-----LKDEVIARIAEKHNATAAQVILAW 210
Cdd:cd19107 164 KPGlKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGspdrpWAKPedpslLEDPKIKEIAAKHNKTTAQVLIRF 243
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 550714234 211 AIGEGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAALECNDR 255
Cdd:cd19107 244 PIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATILSFNRNWR 288
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
3-244 |
2.67e-53 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 174.61 E-value: 2.67e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDD--VVIASVKTALELGYRAIDTAQIYDNEAAVGQAI----EESGVPRHELFITTKIWieNLSKDKLI 76
Cdd:cd19119 12 IPALGLGTASPHEDraEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIkraiDDGSIKREELFITTKVW--PTFYDEVE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 77 PSLKESLKKLRTDYVDLTLIHWPSP--------GDAFSVE---------------EFMQALLEAKEQGLTREIGISNFTI 133
Cdd:cd19119 90 RSLDESLKALGLDYVDLLLVHWPVCfekdsddsGKPFTPVnddgktryaasgdhiTTYKQLEKIYLDGRAKAIGVSNYSI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 134 PLMEKAIAAVgKENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTLAYGKA--LKDEVIARIAEKHNATAAQVILAWA 211
Cdd:cd19119 170 VYLERLIKEC-KVVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLGSHGApnLKNPLVKKIAEKYNVSTGDILISYH 248
|
250 260 270
....*....|....*....|....*....|...
gi 550714234 212 IGEGYAVIPSSTKRENLASNLLAWDLQLDDEDK 244
Cdd:cd19119 249 VRQGVIVLPKSLKPVRIVSNGKIVSLTKEDLQK 281
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
1-250 |
7.40e-53 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 174.21 E-value: 7.40e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTFRL-------KDDVVIASVKTALELGYRAIDTAQIY---DNEAAVGQAIEesGVPRHELFITTKI----- 65
Cdd:COG0667 11 LKVSRLGLGTMTFggpwggvDEAEAIAILDAALDAGINFFDTADVYgpgRSEELLGEALK--GRPRDDVVIATKVgrrmg 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 66 ---WIENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGDAfsVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIA- 141
Cdd:COG0667 89 pgpNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTP--IEETLGALDELVREGKIRYIGVSNYSAEQLRRALAi 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 142 AVGKENIATNQIELSpyLQNRK----VVDWAKQQGIHITSYMTLAYG----KALKD------------------------ 189
Cdd:COG0667 167 AEGLPPIVAVQNEYS--LLDRSaeeeLLPAARELGVGVLAYSPLAGGlltgKYRRGatfpegdraatnfvqgylternla 244
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 550714234 190 --EVIARIAEKHNATAAQVILAWAIGEGY--AVIPSSTKRENLASNLLAWDLQLDDEDKKAIAAL 250
Cdd:COG0667 245 lvDALRAIAAEHGVTPAQLALAWLLAQPGvtSVIPGARSPEQLEENLAAADLELSAEDLAALDAA 309
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
3-256 |
1.79e-52 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 173.10 E-value: 1.79e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEE---SG-VPRHELFITTKIWIENLSKDKLIPS 78
Cdd:cd19155 12 MPVVGLGTWQSSPEEIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKKwidSGkVKREELFIVTKLPPGGNRREKVEKF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 79 LKESLKKLRTDYVDLTLIHWP-----------SPGDAFSVEEFMQ--------ALLEAKEQGLTREIGISNFTIPLMEKa 139
Cdd:cd19155 92 LLKSLEKLQLDYVDLYLIHFPvgslskeddsgKLDPTGEHKQDYTtdlldiwkAMEAQVDQGLTRSIGLSNFNREQMAR- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 140 IAAVGKENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTL-----------------AYGKALKDEVIARIAEKHNAT 202
Cdd:cd19155 171 ILKNARIKPANLQVELHVYLQQKDLVDFCSTHSITVTAYAPLgspgaahfspgtgspsgSSPDLLQDPVVKAIAERHGKS 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 550714234 203 AAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAALECNDRL 256
Cdd:cd19155 251 PAQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLSSLDKNIRG 304
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
2-257 |
1.03e-51 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 171.14 E-value: 1.03e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGTF----RLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQAIEES----GVPRHELFITTKIWIENLSKD 73
Cdd:cd19109 3 SIPIIGLGTYsepkTTPKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKiaegKVKREDIFYCGKLWNTCHPPE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 74 KLIPSLKESLKKLRTDYVDLTLIHWP---SPGDAF--------------SVEEFMQALLEAKEQGLTREIGISNFTIPLM 136
Cdd:cd19109 83 LVRPTLERTLKVLQLDYVDLYIIEMPmafKPGDEIyprdengkwlyhktNLCATWEALEACKDAGLVKSIGVSNFNRRQL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 137 EKAIAAVG-KENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTLAYGKA-----------LKDEVIARIAEKHNATAA 204
Cdd:cd19109 163 ELILNKPGlKHKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGTCRDpiwvnvsspplLEDPLLNSIGKKYNKTAA 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 550714234 205 QVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAALECNDRLV 257
Cdd:cd19109 243 QVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALNKNVRYV 295
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
3-259 |
1.86e-51 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 170.29 E-value: 1.86e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVGQ----AIEESGVPRHELFITTKIWIENLSKDKLIPS 78
Cdd:cd19115 13 MPLVGFGLWKVNNDTCADQVYNAIKAGYRLFDGACDYGNEVEAGQgvarAIKEGIVKREDLFIVSKLWNTFHDGERVEPI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 79 LKESLKKLRTDYVDLTLIHWP-----------------SPGDAF-----SVEEFMQALLEAKEQGLTREIGISNFTIPL- 135
Cdd:cd19115 93 CRKQLADWGIDYFDLFLIHFPialkyvdpavryppgwfYDGKKVefsnaPIQETWTAMEKLVDKGLARSIGVSNFSAQLl 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 136 MEKAIAAvgKENIATNQIELSPYLQNRKVVDWAKQQGIHIT--------SYMTLAYGKA------LKDEVIARIAEKHNA 201
Cdd:cd19115 173 MDLLRYA--RIRPATLQIEHHPYLTQPRLVKYAQKEGIAVTayssfgpqSFLELDLPGAkdtpplFEHDVIKSIAEKHGK 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 550714234 202 TAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAALECNDRLVSP 259
Cdd:cd19115 251 TPAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAISALDIGLRFNNP 308
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
3-255 |
2.59e-50 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 167.02 E-value: 2.59e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFR----LKDDVVIAsVKTALELGYRAIDTAQIYDNEAAVGQAI----EESGVPRHELFITTKIWIENLSKDK 74
Cdd:cd19108 11 IPVLGFGTYApeevPKSKALEA-TKLAIDAGFRHIDSAYLYQNEEEVGQAIrskiADGTVKREDIFYTSKLWCTFHRPEL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 75 LIPSLKESLKKLRTDYVDLTLIHWP---SPGDA-FSVEEFMQALL---------EA----KEQGLTREIGISNFTIPLME 137
Cdd:cd19108 90 VRPALEKSLKKLQLDYVDLYLIHFPvalKPGEElFPKDENGKLIFdtvdlcatwEAmekcKDAGLAKSIGVSNFNRRQLE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 138 KAIAAVG-KENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTLAYGKA-----------LKDEVIARIAEKHNATAAQ 205
Cdd:cd19108 170 MILNKPGlKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDkewvdqnspvlLEDPVLCALAKKHKRTPAL 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 550714234 206 VILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAALECNDR 255
Cdd:cd19108 250 IALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLR 299
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
3-247 |
2.72e-48 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 161.60 E-value: 2.72e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRL---------KDDVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIEEsgvPRHELFITTKIWIENL 70
Cdd:cd19085 1 VSRLGLGCWQFgggywwgdqDDEESIATIHAALDAGINFFDTAEAYGDghsEEVLGKALKG---RRDDVVIATKVSPDNL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 71 SKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGdaFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVgkeNIAT 150
Cdd:cd19085 78 TPEDVRKSCERSLKRLGTDYIDLYQIHWPSSD--VPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEEALDAG---RIDS 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 151 NQIelsPY-LQNR----KVVDWAKQQGIHITSYMTLAYG----------------------------------KALkdEV 191
Cdd:cd19085 153 NQL---PYnLLWRaieyEILPFCREHGIGVLAYSPLAQGlltgkfssaedfppgdartrlfrhfepgaeeetfEAL--EK 227
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 550714234 192 IARIAEKHNATAAQVILAWAIGEGY--AVIPSSTKRENLASNLLAWDLQLDDEDKKAI 247
Cdd:cd19085 228 LKEIADELGVTMAQLALAWVLQQPGvtSVIVGARNPEQLEENAAAVDLELSPSVLERL 285
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
3-256 |
3.48e-47 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 158.97 E-value: 3.48e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVIASVKTALELGYRAIDTAQIYDNEAAVG----QAIEESGVPRHELFITTKIWIENLSKDKLIPS 78
Cdd:cd19110 4 IPAVGLGTWKASPGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGagirEKIKEGVVRREDLFIVSKLWCTCHKKSLVKTA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 79 LKESLKKLRTDYVDLTLIHWP---SPGDA-----------FSVEEFMQAlLEAKE----QGLTREIGISNFTIPLMEKAI 140
Cdd:cd19110 84 CTRSLKALKLNYLDLYLIHWPmgfKPGEPdlpldrsgmviPSDTDFLDT-WEAMEdlviEGLVKNIGVSNFNHEQLERLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 141 AAVG-KENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTLAyGKA-----LKDEVIARIAEKHNATAAQVILAWAIGE 214
Cdd:cd19110 163 NKPGlRVKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPLG-GSCegvdlIDDPVIQRIAKKHGKSPAQILIRFQIQR 241
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 550714234 215 GYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAALECNDRL 256
Cdd:cd19110 242 NVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRL 283
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
2-227 |
3.52e-46 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 156.46 E-value: 3.52e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGTFrLKDDVVIAS-VKTALELGYRAIDTAQIYDNEAAVGQAIEE----SGVPRHELFITTKIWIENLSKDKLI 76
Cdd:cd19129 5 AIPALGFGTL-IPDPSATRNaVKAALEAGFRHFDCAERYRNEAEVGEAMQEvfkaGKIRREDLFVTTKLWNTNHRPERVK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 77 PSLKESLKKLRTDYVDLTLIHWP---SPGD---------------AFSVEEFMQALLEAKEQGLTREIGISNFTIPLMeK 138
Cdd:cd19129 84 PAFEASLKRLQLDYLDLYLIHTPfafQPGDeqdprdangnviyddGVTLLDTWRAMERLVDEGRCKAIGLSDVSLEKL-R 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 139 AIAAVGKENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTLAYG---KALKDEVIARIAEKHNATAAQVILAWAIGEG 215
Cdd:cd19129 163 EIFEAARIKPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLGHGmepKLLEDPVITAIARRVNKTPAQVLLAWAIQRG 242
|
250
....*....|....*.
gi 550714234 216 YAVIPSSTK----REN 227
Cdd:cd19129 243 TALLTTSKTpsriREN 258
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
4-232 |
3.26e-44 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 149.21 E-value: 3.26e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 4 PALGLGTFRLKDDV----VIASVKTALELGYRAIDTAQIY---DNEAAVGQAIEESGVpRHELFITTKI--------WIE 68
Cdd:cd06660 1 SRLGLGTMTFGGDGdeeeAFALLDAALEAGGNFFDTADVYgdgRSERLLGRWLKGRGN-RDDVVIATKGghppggdpSRS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 69 NLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAV---GK 145
Cdd:cd06660 80 RLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDP--STPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYAkahGL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 146 ENIATNQIELS---PYLQNRKVVDWAKQQGIHITSYMTLAYGkalkdeviariaekhnatAAQVILAWAIGEGY--AVIP 220
Cdd:cd06660 158 PGFAAVQPQYSlldRSPMEEELLDWAEENGLPLLAYSPLARG------------------PAQLALAWLLSQPFvtVPIV 219
|
250
....*....|..
gi 550714234 221 SSTKRENLASNL 232
Cdd:cd06660 220 GARSPEQLEENL 231
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
2-250 |
2.93e-43 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 148.54 E-value: 2.93e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGTFRLKDDV--VIASVKTALELGYRAIDTAQIYDNEAAVGQAI-----EESGVPRHELFITTKIWIENLSKDK 74
Cdd:cd19122 8 KIPAVGFGTFANEGAKgeTYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVrdflkENPSVKREDLFICTKVWNHLHEPED 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 75 LIPSLKESLKKLRTDYVDLTLIHWP-------------SPGDAFSVEEFM--------QALLEAKEQGLTREIGISNFTI 133
Cdd:cd19122 88 VKWSIDNSLKNLKLDYIDLFLVHWPiaaekndqrspklGPDGKYVILKDLtenpeptwRAMEEIYESGKAKAIGVSNWTI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 134 PLMEKaIAAVGKENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTL-------AYGKALKD-EVIARIAEKHNATAAQ 205
Cdd:cd19122 168 PGLKK-LLSFAKVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLgsqnqvpSTGERVSEnPTLNEVAEKGGYSLAQ 246
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 550714234 206 VILAWAIGEGYAVIPSSTKRENLASNLLAwdLQLDDEDKKAIAAL 250
Cdd:cd19122 247 VLIAWGLRRGYVVLPKSSTPSRIESNFKS--IELSDEDFEAINQV 289
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
1-247 |
2.42e-41 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 143.82 E-value: 2.42e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTF--------RLKDDVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIEESgvpRHELFITTK---IW 66
Cdd:cd19084 2 LKVSRIGLGTWaiggtwwgEVDDQESIEAIKAAIDLGINFFDTAPVYGFghsEEILGKALKGR---RDDVVIATKcglRW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 67 IE------NLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAI 140
Cdd:cd19084 79 DGgkgvtkDLSPESIRKEVEQSLRRLQTDYIDLYQIHWPDP--NTPIEETAEALEKLKKEGKIRYIGVSNFSVEQLEEAR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 141 AAVgkeNIATNQIELSPYLQN--RKVVDWAKQQGIHITSYMTLAYG------------------------------KALK 188
Cdd:cd19084 157 KYG---PIVSLQPPYSMLEREieEELLPYCRENGIGVLPYGPLAQGlltgkykkeptfppddrrsrfpffrgenfeKNLE 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550714234 189 D-EVIARIAEKHNATAAQVILAWAIG--EGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAI 247
Cdd:cd19084 234 IvDKLKEIAEKYGKSLAQLAIAWTLAqpGVTSAIVGAKNPEQLEENAGALDWELTEEELKEI 295
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
3-251 |
2.66e-40 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 140.83 E-value: 2.66e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTF-----------RLKDDVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIEESGvPRHELFITTKIWIE 68
Cdd:cd19093 2 VSPLGLGTWqwgdrlwwgygEYGDEDLQAAFDAALEAGVNLFDTAEVYGTgrsERLLGRFLKELG-DRDEVVIATKFAPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 69 --NLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGDAfSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKE 146
Cdd:cd19093 81 pwRLTRRSVVKALKASLERLGLDSIDLYQLHWPGPWYS-QIEALMDGLADAVEEGLVRAVGVSNYSADQLRRAHKALKER 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 147 NI--ATNQIE---LSPYLQNRKVVDWAKQQGIHITSYMTLAYG----------------------KALKD-----EVIAR 194
Cdd:cd19093 160 GVplASNQVEyslLYRDPEQNGLLPACDELGITLIAYSPLAQGlltgkyspenpppggrrrlfgrKNLEKvqpllDALEE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 550714234 195 IAEKHNATAAQVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLDDEDkkaIAALE 251
Cdd:cd19093 240 IAEKYGKTPAQVALNWLIAKGVVPIPGAKNAEQAEENAGALGWRLSEEE---VAELD 293
|
|
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
1-243 |
9.20e-38 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 134.51 E-value: 9.20e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTFRLKD-----DVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIEESGVPRHELFITTKIWIE---- 68
Cdd:COG4989 11 LSVSRIVLGCMRLGEwdlspAEAAALIEAALELGITTFDHADIYGGytcEALFGEALKLSPSLREKIELQTKCGIRlpse 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 69 ---------NLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFT---IPLM 136
Cdd:COG4989 91 ardnrvkhyDTSKEHIIASVEGSLRRLGTDYLDLLLLHRPDP--LMDPEEVAEAFDELKASGKVRHFGVSNFTpsqFELL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 137 EKAIaavgKENIATNQIELSPY----LQNRkVVDWAKQQGIHITSYMTLAYGKALKD---------EVIARIAEKHNATA 203
Cdd:COG4989 169 QSAL----DQPLVTNQIELSLLhtdaFDDG-TLDYCQLNGITPMAWSPLAGGRLFGGfdeqfprlrAALDELAEKYGVSP 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 550714234 204 AQVILAW----------AIGegyavipsSTKRENLASNLLAWDLQLDDED 243
Cdd:COG4989 244 EAIALAWllrhpagiqpVIG--------TTNPERIKAAAAALDIELTREE 285
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
1-243 |
3.99e-37 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 132.29 E-value: 3.99e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTFRLKDDV-----VIASVKTALELGYRAIDTAQIYDN---EAAVGQAIEESGVPRHELFITTKIWIE---- 68
Cdd:cd19092 4 LEVSRLVLGCMRLADWGesaeeLLSLIEAALELGITTFDHADIYGGgkcEELFGEALALNPGLREKIEIQTKCGIRlgdd 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 69 ---------NLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEkA 139
Cdd:cd19092 84 prpgrikhyDTSKEHILASVEGSLKRLGTDYLDLLLLHRPDP--LMDPEEVAEAFDELVKSGKVRYFGVSNFTPSQIE-L 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 140 IAAVGKENIATNQIELSPY---LQNRKVVDWAKQQGIHITSYMTLAYGKALKD---------EVIARIAEKHNATAAQVI 207
Cdd:cd19092 161 LQSYLDQPLVTNQIELSLLhteAIDDGTLDYCQLLDITPMAWSPLGGGRLFGGfderfqrlrAALEELAEEYGVTIEAIA 240
|
250 260 270
....*....|....*....|....*....|....*...
gi 550714234 208 LAWAIGEGYAVIP--SSTKRENLASNLLAWDLQLDDED 243
Cdd:cd19092 241 LAWLLRHPARIQPilGTTNPERIRSAVKALDIELTREE 278
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
3-240 |
1.30e-35 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 127.72 E-value: 1.30e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRL----------KDDVVIASVKTALELGYRAIDTAQIY---DNEAAVGQAIEesgvPRHE-LFITTKI--- 65
Cdd:cd19088 1 VSRLGYGAMRLtgpgiwgppaDREEAIAVLRRALELGVNFIDTADSYgpdVNERLIAEALH----PYPDdVVIATKGglv 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 66 ------WIENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGdaFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKA 139
Cdd:cd19088 77 rtgpgwWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRIDPK--VPFEEQLGALAELQDEGLIRHIGLSNVTVAQIEEA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 140 IAAVGkenIATNQIELSPYlqNRK---VVDWAKQQGIHITSYMTLAYGKALKDEV-IARIAEKHNATAAQVILAW--AIG 213
Cdd:cd19088 155 RAIVR---IVSVQNRYNLA--NRDdegVLDYCEAAGIAFIPWFPLGGGDLAQPGGlLAEVAARLGATPAQVALAWllARS 229
|
250 260
....*....|....*....|....*..
gi 550714234 214 EGYAVIPSSTKRENLASNLLAWDLQLD 240
Cdd:cd19088 230 PVMLPIPGTSSVEHLEENLAAAGLRLS 256
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
3-250 |
6.44e-34 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 124.32 E-value: 6.44e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRL------------KDDVVIASVKTALELGYRAIDTAQIY---DNEAAVGQAIEESgvpRHELFITTK--- 64
Cdd:cd19102 1 LTTIGLGTWAIggggwgggwgpqDDRDSIAAIRAALDLGINWIDTAAVYglgHSEEVVGRALKGL---RDRPIVATKcgl 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 65 IWIEN------LSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGDafSVEEFMQALLEAKEQGLTREIGISNFTIPLMeK 138
Cdd:cd19102 78 LWDEEgrirrsLKPASIRAECEASLRRLGVDVIDLYQIHWPDPDE--PIEEAWGALAELKEEGKVRAIGVSNFSVDQM-K 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 139 AIAAVGkeNIATNQIELSpyLQNR----KVVDWAKQQGIHITSYMTLAYG---KALKDEVIAR----------------- 194
Cdd:cd19102 155 RCQAIH--PIASLQPPYS--LLRRgieaEILPFCAEHGIGVIVYSPMQSGlltGKMTPERVASlpaddwrrrspffqepn 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550714234 195 -------------IAEKHNATAAQVILAWAIG--EGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAAL 250
Cdd:cd19102 231 larnlalvdalrpIAERHGRTVAQLAIAWVLRrpEVTSAIVGARRPDQIDETVGAADLRLTPEELAEIEAL 301
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
4-234 |
4.27e-31 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 115.79 E-value: 4.27e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 4 PALGLGTFRLKDDVVIASVK-------TALELGYRAIDTAQIYDN-EAAVGQAIeeSGVPRHELFITTKIWIEN------ 69
Cdd:cd19095 1 SVLGLGTSGIGRVWGVPSEAeaarllnTALDLGINLIDTAPAYGRsEERLGRAL--AGLRRDDLFIATKVGTHGeggrdr 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 70 --LSKDKLIPSLKESLKKLRTDYVDLTLIHwpSPGDAFSVEEFMQALLEAKEQGLTREIGISNFTiPLMEKAIAAvgkEN 147
Cdd:cd19095 79 kdFSPAAIRASIERSLRRLGTDYIDLLQLH--GPSDDELTGEVLETLEDLKAAGKVRYIGVSGDG-EELEAAIAS---GV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 148 IATNQIELSPYLQ-NRKVVDWAKQQGIHITSYMTLAYGKALKDE-----------VIARIAEKHNATAAQVILAWAIGEG 215
Cdd:cd19095 153 FDVVQLPYNVLDReEEELLPLAAEAGLGVIVNRPLANGRLRRRVrrrplyadyarRPEFAAEIGGATWAQAALRFVLSHP 232
|
250 260
....*....|....*....|.
gi 550714234 216 Y--AVIPSSTKRENLASNLLA 234
Cdd:cd19095 233 GvsSAIVGTTNPEHLEENLAA 253
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
1-249 |
5.81e-31 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 116.99 E-value: 5.81e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTF---------RLKDDVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIEESgvpRHELFITTK---I 65
Cdd:cd19149 9 IEASVIGLGTWaigggpwwgGSDDNESIRTIHAALDLGINLIDTAPAYGFghsEEIVGKAIKGR---RDKVVLATKcglR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 66 WIE----------------NLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGIS 129
Cdd:cd19149 86 WDReggsfffvrdgvtvykNLSPESIREEVEQSLKRLGTDYIDLYQTHWQDV--ETPIEETMEALEELKRQGKIRAIGAS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 130 NFTIPLMEKAIAAVgkeNIATNQIELSpyLQNRKV----VDWAKQQGIHITSYMTLAYG----KALKD------------ 189
Cdd:cd19149 164 NVSVEQIKEYVKAG---QLDIIQEKYS--MLDRGIekelLPYCKKNNIAFQAYSPLEQGlltgKITPDrefdagdarsgi 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550714234 190 ---------------EVIARIAEKHNATAAQVILAWAIGEG--YAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAA 249
Cdd:cd19149 239 pwfspenrekvlallEKWKPLCEKYGCTLAQLVIAWTLAQPgiTSALCGARKPEQAEENAKAGDIRLSAEDIATMRS 315
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
6-250 |
2.17e-30 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 115.21 E-value: 2.17e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 6 LGLGT---------FRLKDDVVIASVKTALELGYRAIDTAQIYD---NEAAVGQAIEESGvpRHELFITTK--------- 64
Cdd:cd19083 14 IGLGTnavgghnlyPNLDEEEGKDLVREALDNGVNLLDTAFIYGlgrSEELVGEVLKEYN--RNEVVIATKgahkfggdg 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 65 IWIENlSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGDAfsVEEFMQALLEAKEQGLTREIGISNFTIPLMeKAIAAVG 144
Cdd:cd19083 92 SVLNN-SPEFLRSAVEKSLKRLNTDYIDLYYIHFPDGETP--KAEAVGALQELKDEGKIRAIGVSNFSLEQL-KEANKDG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 145 KENIATNQIELSPYLQNRKVVDWAKQQGIHITSYMTLAY----GKALKD---------------------------EVIA 193
Cdd:cd19083 168 YVDVLQGEYNLLQREAEEDILPYCVENNISFIPYFPLASgllaGKYTKDtkfpdndlrndkplfkgerfsenldkvDKLK 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 550714234 194 RIAEKHNATAAQVILAWAIGEGY--AVIPSSTKRENLASNLLAWDLQLDDEDKKAIAAL 250
Cdd:cd19083 248 SIADEKGVTVAHLALAWYLTRPAidVVIPGAKRAEQVIDNLKALDVTLTEEEIAFIDAL 306
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
1-247 |
2.46e-30 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 115.01 E-value: 2.46e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTFRL-------KDDVVIASVKTALELGYRAIDTAQIY---DNEAAVGQAIEEsgvPRHELFITTKIWIENL 70
Cdd:cd19076 10 LEVSALGLGCMGMsafygpaDEEESIATLHRALELGVTFLDTADMYgpgTNEELLGKALKD---RRDEVVIATKFGIVRD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 71 SKDKLIP----------SLKESLKKLRTDYVDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAi 140
Cdd:cd19076 87 PGSGFRGvdgrpeyvraACEASLKRLGTDVIDLYYQHRVDP--NVPIEETVGAMAELVEEGKVRYIGLSEASADTIRRA- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 141 AAVGKenIATNQIELSPYLQN--RKVVDWAKQQGIHITSYMTLAYG------KALKD----------------------- 189
Cdd:cd19076 164 HAVHP--ITAVQSEYSLWTRDieDEVLPTCRELGIGFVAYSPLGRGfltgaiKSPEDlpeddfrrnnprfqgenfdknlk 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550714234 190 --EVIARIAEKHNATAAQVILAWAIGEGYAV--IPSSTKRENLASNLLAWDLQLDDEDKKAI 247
Cdd:cd19076 242 lvEKLEAIAAEKGCTPAQLALAWVLAQGDDIvpIPGTKRIKYLEENVGALDVVLTPEELAEI 303
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
22-247 |
4.01e-30 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 114.60 E-value: 4.01e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 22 VKTALELGYRAIDTAQIYDN---EAAVGQAIEESGvPRHELFITTKIWI--------ENLSKDKLIPSLKESLKKLRTDY 90
Cdd:cd19079 41 IKRALDLGINFFDTANVYSGgasEEILGRALKEFA-PRDEVVIATKVYFpmgdgpngRGLSRKHIMAEVDASLKRLGTDY 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 91 VDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKENiatnqieLSPY--LQN------- 161
Cdd:cd19079 120 IDLYQIHRWDY--ETPIEETLEALHDVVKSGKVRYIGASSMYAWQFAKALHLAEKNG-------WTKFvsMQNhynllyr 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 162 ---RKVVDWAKQQGIHITSYMTLAYG--------------------KALKD-------EVIAR---IAEKHNATAAQVIL 208
Cdd:cd19079 191 eeeREMIPLCEEEGIGVIPWSPLARGrlarpwgdtterrrsttdtaKLKYDyfteadkEIVDRveeVAKERGVSMAQVAL 270
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 550714234 209 AWAIGEGYAVIP--SSTKRENLASNLLAWDLQLDDEDKKAI 247
Cdd:cd19079 271 AWLLSKPGVTAPivGATKLEHLEDAVAALDIKLSEEEIKYL 311
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
1-232 |
1.25e-29 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 111.91 E-value: 1.25e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTFRLkDDVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIeeSGVPRHELFITTKIWIENLSKDK--L 75
Cdd:cd19105 11 LKVSRLGFGGGGL-PRESPELLRRALDLGINYFDTAEGYGNgnsEEIIGEAL--KGLRRDKVFLATKASPRLDKKDKaeL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 76 IPSLKESLKKLRTDYVDLTLIHWPSPGD-AFSVEEFMQALLEAKEQGLTREIGIS-NFTIPlmEKAIAAVGKENIATNQI 153
Cdd:cd19105 88 LKSVEESLKRLQTDYIDIYQLHGVDTPEeRLLNEELLEALEKLKKEGKVRFIGFStHDNMA--EVLQAAIESGWFDVIMV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 154 ELSPYLQN---RKVVDWAKQQGIHITSYMTLAYGKALKDEviARIAEKHNATAAQVILAWAIGEGY--AVIPSSTKRENL 228
Cdd:cd19105 166 AYNFLNQPaelEEALAAAAEKGIGVVAMKTLAGGYLQPAL--LSVLKAKGFSLPQAALKWVLSNPRvdTVVPGMRNFAEL 243
|
....
gi 550714234 229 ASNL 232
Cdd:cd19105 244 EENL 247
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
2-247 |
3.25e-29 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 112.54 E-value: 3.25e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGTF--------RLKDDVVIASVKTALELGYRAIDTAQIY-DNEAAVGQAIEESGVPRHELFITTKIWIE---- 68
Cdd:cd19144 12 SVPALGFGAMglsafygpPKPDEERFAVLDAAFELGCTFWDTADIYgDSEELIGRWFKQNPGKREKIFLATKFGIEknve 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 69 ------NLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAA 142
Cdd:cd19144 92 tgeysvDGSPEYVKKACETSLKRLGVDYIDLYYQHRVDG--KTPIEKTVAAMAELVQEGKIKHIGLSECSAETLRRAHAV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 143 vgkENIATNQIELSPYL-----QNRKVVDWAKQQGIHITSYMTLAYG--------------------------------K 185
Cdd:cd19144 170 ---HPIAAVQIEYSPFSldierPEIGVLDTCRELGVAIVAYSPLGRGfltgairspddfeegdfrrmaprfqaenfpknL 246
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550714234 186 ALKDEvIARIAEKHNATAAQVILAW--AIGEGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAI 247
Cdd:cd19144 247 ELVDK-IKAIAKKKNVTAGQLTLAWllAQGDDIIPIPGTTKLKRLEENLGALKVKLTEEEEKEI 309
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
1-251 |
5.08e-29 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 112.61 E-value: 5.08e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTFRL--KD-DVVIASVKTALELGYRAIDTAQIY-DNEAAVGQAIEEsgvPRHELFITTKI--WIENlsKDK 74
Cdd:COG1453 11 LEVSVLGFGGMRLprKDeEEAEALIRRAIDNGINYIDTARGYgDSEEFLGKALKG---PRDKVILATKLppWVRD--PED 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 75 LIPSLKESLKKLRTDYVDLTLIH-------WPSPGDAFsveEFMQALLEAKEQGLTREIGISNF-TIPLMEKAIAAvgkE 146
Cdd:COG1453 86 MRKDLEESLKRLQTDYIDLYLIHglnteedLEKVLKPG---GALEALEKAKAEGKIRHIGFSTHgSLEVIKEAIDT---G 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 147 NIATNQIELSPYLQN----RKVVDWAKQQGIHITSyM-TLAYGK-ALKDEVIARIAEKHNATAAQVIL-AWAIGEGYAVI 219
Cdd:COG1453 160 DFDFVQLQYNYLDQDnqagEEALEAAAEKGIGVII-MkPLKGGRlANPPEKLVELLCPPLSPAEWALRfLLSHPEVTTVL 238
|
250 260 270
....*....|....*....|....*....|....
gi 550714234 220 PSSTKRENLASNLLAWDL--QLDDEDKKAIAALE 251
Cdd:COG1453 239 SGMSTPEQLDENLKTADNlePLTEEELAILERLA 272
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
4-140 |
1.70e-28 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 109.57 E-value: 1.70e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 4 PALGLGTFRL-------KDDVVIASVKTALELGYRAIDTAQIY-DNEAAVGQAIEEsgVPRHELFITTKI-----WIENL 70
Cdd:cd19090 1 SALGLGTAGLggvfggvDDDEAVATIRAALDLGINYIDTAPAYgDSEERLGLALAE--LPREPLVLSTKVgrlpeDTADY 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550714234 71 SKDKLIPSLKESLKKLRTDYVDLTLIH---WPSPGDAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAI 140
Cdd:cd19090 79 SADRVRRSVEESLERLGRDRIDLLMIHdpeRVPWVDILAPGGALEALLELKEEGLIKHIGLGGGPPDLLRRAI 151
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
1-140 |
2.35e-27 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 105.64 E-value: 2.35e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGT---FRLKDDVVIASVKTALELGYRAIDTAQIY-DNEAAVGQAIEEsgvPRHELFITTKIWieNLSKDKLI 76
Cdd:cd19100 9 LKVSRLGFGGgplGRLSQEEAAAIIRRALDLGINYFDTAPSYgDSEEKIGKALKG---RRDKVFLATKTG--ARDYEGAK 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550714234 77 PSLKESLKKLRTDYVDLTLIHWPS----PGDAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAI 140
Cdd:cd19100 84 RDLERSLKRLGTDYIDLYQLHAVDteedLDQVFGPGGALEALLEAKEEGKIRFIGISGHSPEVLLRAL 151
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
22-251 |
1.74e-26 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 105.00 E-value: 1.74e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 22 VKTALELGYRAIDTAQIYDN---EAAVGQAIEESgvpRHELFITTKI--WIEN------LSKDKLIPSLKESLKKLRTDY 90
Cdd:cd19091 45 VDIALDAGINFFDTADVYSEgesEEILGKALKGR---RDDVLIATKVrgRMGEgpndvgLSRHHIIRAVEASLKRLGTDY 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 91 VDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKENIA---TNQIELSpyLQNR----K 163
Cdd:cd19091 122 IDLYQLHGFDA--LTPLEETLRALDDLVRQGKVRYIGVSNFSAWQIMKALGISERRGLArfvALQAYYS--LLGRdlehE 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 164 VVDWAKQQGIHITSYMTLAY----GKALKD----------------------------EVIARIAEKHNATAAQVILAWA 211
Cdd:cd19091 198 LMPLALDQGVGLLVWSPLAGgllsGKYRRGqpapegsrlrrtgfdfppvdrergydvvDALREIAKETGATPAQVALAWL 277
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 550714234 212 IGEGY--AVIPSSTKRENLASNLLAWDLQLDDEDkkaIAALE 251
Cdd:cd19091 278 LSRPTvsSVIIGARNEEQLEDNLGAAGLSLTPEE---IARLD 316
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
27-247 |
2.41e-26 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 104.60 E-value: 2.41e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 27 ELGYRAIDTAQIY----------DNEAAVGQAIEESGvPRHELFITTKI--WI----ENLSKDKLIPSLKESLKKLRTDY 90
Cdd:cd19081 37 DAGGNFIDTADVYsawvpgnaggESETIIGRWLKSRG-KRDRVVIATKVgfPMgpngPGLSRKHIRRAVEASLRRLQTDY 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 91 VDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKENiatnqieLSPY--LQ------NR 162
Cdd:cd19081 116 IDLYQAHWDDP--ATPLEETLGALNDLIRQGKVRYIGASNYSAWRLQEALELSRQHG-------LPRYvsLQpeynlvDR 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 163 KVVDW-----AKQQGIHITSYMTLAYG-----------------------KALKD------EVIARIAEKHNATAAQVIL 208
Cdd:cd19081 187 ESFEGellplCREEGIGVIPYSPLAGGfltgkyrseadlpgstrrgeaakRYLNErglrilDALDEVAAEHGATPAQVAL 266
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 550714234 209 AWAIGEGY--AVIPSSTKRENLASNLLAWDLQLDDEDKKAI 247
Cdd:cd19081 267 AWLLARPGvtAPIAGARTVEQLEDLLAAAGLRLTDEEVARL 307
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
2-184 |
3.11e-26 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 102.56 E-value: 3.11e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPALGLGTFRL--------KDDVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIEEsgvPRHELFITTKI----- 65
Cdd:cd19086 2 EVSEIGFGTWGLggdwwgdvDDAEAIRALRAALDLGINFFDTADVYGDghsERLLGKALKG---RRDKVVIATKFgnrfd 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 66 ----WIENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPgDAFSVEEFMQALLEAKEQGLTREIGISnfTIPLmEKAIA 141
Cdd:cd19086 79 ggpeRPQDFSPEYIREAVEASLKRLGTDYIDLYQLHNPPD-EVLDNDELFEALEKLKQEGKIRAYGVS--VGDP-EEALA 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 550714234 142 AVGKENIATNQIELSPYLQN--RKVVDWAKQQGIHITSYMTLAYG 184
Cdd:cd19086 155 ALRRGGIDVVQVIYNLLDQRpeEELFPLAEEHGVGVIARVPLASG 199
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
5-234 |
6.05e-26 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 103.02 E-value: 6.05e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 5 ALGLGTFRLKDDVVIAS--VKTALELGYRAIDTAQIY-------DNEAAVGQAIEESGVpRHELFITTK--------IWI 67
Cdd:cd19082 4 VLGTADFGTRIDEEEAFalLDAFVELGGNFIDTARVYgdwvergASERVIGEWLKSRGN-RDKVVIATKgghpdledMSR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 68 ENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIA---AVG 144
Cdd:cd19082 83 SRLSPEDIRADLEESLERLGTDYIDLYFLHRDDP--SVPVGEIVDTLNELVRAGKIRAFGASNWSTERIAEANAyakAHG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 145 KENIATNQIELS------PYLQNRKVV-------DWAKQQGIHITSYMTLAYG---KALK---------------DEVIA 193
Cdd:cd19082 161 LPGFAASSPQWSlarpnePPWPGPTLVamdeemrAWHEENQLPVFAYSSQARGffsKRAAggaeddselrrvyysEENFE 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 550714234 194 R------IAEKHNATAAQVILAWAIGEGYAVIP--SSTKRENLASNLLA 234
Cdd:cd19082 241 RlerakeLAEEKGVSPTQIALAYVLNQPFPTVPiiGPRTPEQLRDSLAA 289
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
19-247 |
1.28e-24 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 99.69 E-value: 1.28e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 19 IASVKTALELGYRAIDTAQIYD---NEAAVGQAIEESGvPRHELFITTKI---WIE------NLSKDKLIPSLKESLKKL 86
Cdd:cd19148 28 IETIHKALDLGINLIDTAPVYGfglSEEIVGKALKEYG-KRDRVVIATKVgleWDEggevvrNSSPARIRKEVEDSLRRL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 87 RTDYVDLTLIHWPSPGDAFsvEEFMQALLEAKEQGLTREIGISNFTIPLME--KAIAAvgkenIATNQielSPY-----L 159
Cdd:cd19148 107 QTDYIDLYQVHWPDPLVPI--EETAEALKELLDEGKIRAIGVSNFSPEQMEtfRKVAP-----LHTVQ---PPYnlferE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 160 QNRKVVDWAKQQGIhitsyMTLAY---------GKALKD---------------------------EVIARIA-EKHNAT 202
Cdd:cd19148 177 IEKDVLPYARKHNI-----VTLAYgalcrgllsGKMTKDtkfegddlrrtdpkfqeprfsqylaavEELDKLAqERYGKS 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 550714234 203 AAQVILAWAIGEGYAVIP--SSTKRENLASNLLAWDLQLDDEDKKAI 247
Cdd:cd19148 252 VIHLAVRWLLDQPGVSIAlwGARKPEQLDAVDEVFGWSLNDEDMKEI 298
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
6-242 |
2.44e-24 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 98.82 E-value: 2.44e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 6 LGLGTF-----RLKDDVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIeeSGVPRHELFITTKI-WI-------EN 69
Cdd:cd19074 7 LSLGTWltfggQVDDEDAKACVRKAYDLGINFFDTADVYAAgqaEEVLGKAL--KGWPRESYVISTKVfWPtgpgpndRG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 70 LSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKENIA 149
Cdd:cd19074 85 LSRKHIFESIHASLKRLQLDYVDIYYCHRYDP--ETPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAEAHDLARQFGLI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 150 T---NQIELSpYLQNRK---VVDWAKQQGIHITSYMTLAYG----------------------------KALKDEVIAR- 194
Cdd:cd19074 163 PpvvEQPQYN-MLWREIeeeVIPLCEKNGIGLVVWSPLAQGlltgkyrdgipppsrsratdednrdkkrRLLTDENLEKv 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 550714234 195 -----IAEKHNATAAQVILAWAIG--EGYAVIPSSTKRENLASNLLAWDLQLDDE 242
Cdd:cd19074 242 kklkpIADELGLTLAQLALAWCLRnpAVSSAIIGASRPEQLEENVKASGVKLSPE 296
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-249 |
1.80e-23 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 96.51 E-value: 1.80e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 14 KDDVVIASVKTALELGYRAIDTAQIY-DNEAAVGQAIEESG---------------VPRHELFITTKIWIENlskdklip 77
Cdd:cd19101 21 DEDAAVRAMAAYVDAGLTTFDCADIYgPAEELIGEFRKRLRrerdaaddvqihtkwVPDPGELTMTRAYVEA-------- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 78 SLKESLKKLRTDYVDLTLIHWPSPGDAfSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKenIATNQIELS- 156
Cdd:cd19101 93 AIDRSLKRLGVDRLDLVQFHWWDYSDP-GYLDAAKHLAELQEEGKIRHLGLTNFDTERLREILDAGVP--IVSNQVQYSl 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 157 ----PylqNRKVVDWAKQQGIHITSYMTLAYG-------------------------KALKDE------------VIARI 195
Cdd:cd19101 170 ldrrP---ENGMAALCEDHGIKLLAYGTLAGGllsekylgvpeptgpaletrslqkyKLMIDEwggwdlfqellrTLKAI 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 550714234 196 AEKHNATAAQVILAWAI---GEGyAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAA 249
Cdd:cd19101 247 ADKHGVSIANVAVRWVLdqpGVA-GVIVGARNSEHIDDNVRAFSFRLDDEDRAAIDA 302
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
5-250 |
6.79e-22 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 92.40 E-value: 6.79e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 5 ALGLGTF--RLKDDVVIASVKTALELGYRAIDTAQIY---DNEAAVGQAIEEsgVPRHELFITTKI--WIENLSKDKLIP 77
Cdd:cd19103 19 AGGDQVFgnHLDEDTLKAVFDKAMAAGLNLWDTAAVYgmgASEKILGEFLKR--YPREDYIISTKFtpQIAGQSADPVAD 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 78 SLKESLKKLRTDYVDLTLIHWPSpgdafSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKENIATNQIELSP 157
Cdd:cd19103 97 MLEGSLARLGTDYIDIYWIHNPA-----DVERWTPELIPLLKSGKVKHVGVSNHNLAEIKRANEILAKAGVSLSAVQNHY 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 158 YLQNRK-----VVDWAKQQGIHITSYMTL-------AYGKA-------------------LKD--EVIARIAEKHNATAA 204
Cdd:cd19103 172 SLLYRSseeagILDYCKENGITFFAYMVLeqgalsgKYDTKhplpegsgraetynpllpqLEEltAVMAEIGAKHGASIA 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 550714234 205 QVILAWAIGEGYAVIPSSTKRENLASNLLAWDLQLDDEDKKAIAAL 250
Cdd:cd19103 252 QVAIAWAIAKGTTPIIGVTKPHHVEDAARAASITLTDDEIKELEQL 297
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
4-234 |
2.26e-20 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 88.16 E-value: 2.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 4 PALGLGT------------FRLKDDVVIAsvktalelGYRAIDTAQIY----------DNEAAVGQAIEESGVpRHELFI 61
Cdd:cd19752 1 SELCLGTmyfgtrtdeetsFAILDRYVAA--------GGNFLDTANNYafwteggvggESERLIGRWLKDRGN-RDDVVI 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 62 TTK------------IWIENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGDAFsvEEFMQALLEAKEQGLTREIGIS 129
Cdd:cd19752 72 ATKvgagprdpdggpESPEGLSAETIEQEIDKSLRRLGTDYIDLYYAHVDDRDTPL--EETLEAFNELVKAGKVRAIGAS 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 130 NFTIPLMEKAiaavgkENIATNQ-------IELS-PYLQNRKVVDWAKQQGIH--------------ITSYMTLAYG--- 184
Cdd:cd19752 150 NFAAWRLERA------RQIARQQgwaefsaIQQRhSYLRPRPGADFGVQRIVTdelldyassrpdltLLAYSPLLSGayt 223
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550714234 185 ---KALKD-----------EVIARIAEKHNATAAQVILAWAIGEGYAVIP--SSTKRENLASNLLA 234
Cdd:cd19752 224 rpdRPLPEqydgpdsdarlAVLEEVAGELGATPNQVVLAWLLHRTPAIIPllGASTVEQLEENLAA 289
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
7-247 |
2.47e-20 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 88.06 E-value: 2.47e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 7 GLGTFRL-------KDDVVIASVKTALELGYRAIDTAQIY------DNEAAVGQAIEESGVPRHELFITTKI-WIENL-- 70
Cdd:cd19077 9 GLGLMGLtwrpnptPDEEAFETMKAALDAGSNLWNGGEFYgppdphANLKLLARFFRKYPEYADKVVLSVKGgLDPDTlr 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 71 ---SKDKLIPSLKESLKKLR-TDYVDltlIHWPSPGD-AFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAiAAVGK 145
Cdd:cd19077 89 pdgSPEAVRKSIENILRALGgTKKID---IFEPARVDpNVPIEETIKALKELVKEGKIRGIGLSEVSAETIRRA-HAVHP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 146 enIATNQIELSPY----LQNrKVVDWAKQQGIHITSYMTLAYG------KALKD-------------------------E 190
Cdd:cd19077 165 --IAAVEVEYSLFsreiEEN-GVLETCAELGIPIIAYSPLGRGlltgriKSLADipegdfrrhldrfngenfeknlklvD 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 191 VIARIAEKHNATAAQVILAWAIGEGYAVI---PSSTKRENLASNLLAWDLQLDDEDKKAI 247
Cdd:cd19077 242 ALQELAEKKGCTPAQLALAWILAQSGPKIipiPGSTTLERVEENLKAANVELTDEELKEI 301
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
33-242 |
7.71e-20 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 86.89 E-value: 7.71e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 33 IDTAQIYDN---EAAVGQAIEESgvpRHELFITTKiWIENLSKDK----------LIPSLKESLKKLRTDYVDLTLIHWP 99
Cdd:cd19080 48 IDTANNYTNgtsERLLGEFIAGN---RDRIVLATK-YTMNRRPGDpnaggnhrknLRRSVEASLRRLQTDYIDLLYVHAW 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 100 spgD-AFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKA--IA-AVGKENIATNQIELSpyLQNRKV----VDWAKQQ 171
Cdd:cd19080 124 ---DfTTPVEEVMRALDDLVRAGKVLYVGISDTPAWVVARAntLAeLRGWSPFVALQIEYS--LLERTPerelLPMARAL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 172 GIHITSYMTLAYGK-------------------------------ALKDEVIArIAEKHNATAAQVILAWAIGEGYAVIP 220
Cdd:cd19080 199 GLGVTPWSPLGGGLltgkyqrgeegrageakgvtvgfgklternwAIVDVVAA-VAEELGRSAAQVALAWVRQKPGVVIP 277
|
250 260
....*....|....*....|....
gi 550714234 221 S--STKRENLASNLLAWDLQLDDE 242
Cdd:cd19080 278 IigARTLEQLKDNLGALDLTLSPE 301
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
5-184 |
1.45e-18 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 82.97 E-value: 1.45e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 5 ALGLGTFRL--------KDDVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIEESGVPRHELFITTKI-----WIE 68
Cdd:cd19153 14 PVGLGTAALggvygdglEQDEAVAIVAEAFAAGINHFDTSPYYGAessEAVLGKALAALQVPRSSYTVATKVgryrdSEF 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 69 NLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGDAFS-VEEFMQALLEAKEQGLTREIGISNFTIPLMEKaiaAVGKEN 147
Cdd:cd19153 94 DYSAERVRASVATSLERLHTTYLDVVYLHDIEFVDYDTlVDEALPALRTLKDEGVIKRIGIAGYPLDTLTR---ATRRCS 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 550714234 148 IATNQIELSpY----LQNRKVVDWA----KQQGIHITSYMTLAYG 184
Cdd:cd19153 171 PGSLDAVLS-YchltLQDARLESDApglvRGAGPHVINASPLSMG 214
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
1-247 |
1.78e-18 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 83.05 E-value: 1.78e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTFRL---------KDDVvIASVKTALELGYRAIDTAQIY---DNEAAVGQAIEEsgvPRHELFITTK--IW 66
Cdd:cd19078 2 LEVSAIGLGCMGMshgygpppdKEEM-IELIRKAVELGITFFDTAEVYgpyTNEELVGEALKP---FRDQVVIATKfgFK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 67 IENLSKDKLIP---------SLKESLKKLRTDYVDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLME 137
Cdd:cd19078 78 IDGGKPGPLGLdsrpehirkAVEGSLKRLQTDYIDLYYQHRVDP--NVPIEEVAGTMKELIKEGKIRHWGLSEAGVETIR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 138 KA-----IAAVGKE-NIATNQIE--LSPYLQnrkvvdwakQQGIHITSYMTLAYG------------------------- 184
Cdd:cd19078 156 RAhavcpVTAVQSEySMMWREPEkeVLPTLE---------ELGIGFVPFSPLGKGfltgkidentkfdegddraslprft 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550714234 185 -KALKD-----EVIARIAEKHNATAAQVILAWAIGEG-YAV-IPSSTKRENLASNLLAWDLQLDDEDKKAI 247
Cdd:cd19078 227 pEALEAnqalvDLLKEFAEEKGATPAQIALAWLLAKKpWIVpIPGTTKLSRLEENIGAADIELTPEELREI 297
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
4-173 |
3.60e-18 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 81.45 E-value: 3.60e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 4 PALGLGTFRLKD--------DVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIeeSGVPRHELFITTKI-WIENLS 71
Cdd:cd19096 1 SVLGFGTMRLPEsdddsideEKAIEMIRYAIDAGINYFDTAYGYGGgksEEILGEAL--KEGPREKFYLATKLpPWSVKS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 72 KDKLIPSLKESLKKLRTDYVDLTLIHWP-SPGDAFSVEEF--MQALLEAKEQGLTREIGISnF--TIPLMEKAIAAvgkE 146
Cdd:cd19096 79 AEDFRRILEESLKRLGVDYIDFYLLHGLnSPEWLEKARKGglLEFLEKAKKEGLIRHIGFS-FhdSPELLKEILDS---Y 154
|
170 180 190
....*....|....*....|....*....|.
gi 550714234 147 NIATNQIELS----PYLQNRKVVDWAKQQGI 173
Cdd:cd19096 155 DFDFVQLQYNyldqENQAGRPGIEYAAKKGM 185
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
5-250 |
1.22e-17 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 80.69 E-value: 1.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 5 ALGLGTF--RLKDDVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIEESgvpRHELFITTK--------IWIENLS 71
Cdd:cd19087 17 CLGTMNFggRTDEETSFAIMDRALDAGINFFDTADVYGGgrsEEIIGRWIAGR---RDDIVLATKvfgpmgddPNDRGLS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 72 KDKLIPSLKESLKKLRTDYVDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKENIATN 151
Cdd:cd19087 94 RRHIRRAVEASLRRLQTDYIDLYQMHHFDR--DTPLEETLRALDDLVRQGKIRYIGVSNFAAWQIAKAQGIAARRGLLRF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 152 QIELSPY-LQNR----KVVDWAKQQGIHITSYMTLA-------YGKALKDEV------------------------IARI 195
Cdd:cd19087 172 VSEQPMYnLLKRqaelEILPAARAYGLGVIPYSPLAgglltgkYGKGKRPESgrlveraryqarygleeyrdiaerFEAL 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 550714234 196 AEKHNATAAQVILAWAIGE---GYAVIPSSTKrENLASNLLAWDLQLDDEDKKAIAAL 250
Cdd:cd19087 252 AAEAGLTPASLALAWVLSHpavTSPIIGPRTL-EQLEDSLAALEITLTPELLAEIDEL 308
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
14-243 |
1.34e-17 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 80.40 E-value: 1.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 14 KD-DVVIASVKTALELGYRAIDTAQIYdNEAAVGQAIEESGVP-RHELFITTKI---------WIENLSKDKLIPSLKES 82
Cdd:PRK10376 37 KDrDAAIAVLREAVALGVNHIDTSDFY-GPHVTNQLIREALHPyPDDLTIVTKVgarrgedgsWLPAFSPAELRRAVHDN 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 83 LKKLRT---DYVDLTL---IHWPSPGdafSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAiaavgkENIAT-----N 151
Cdd:PRK10376 116 LRNLGLdvlDVVNLRLmgdGHGPAEG---SIEEPLTVLAELQRQGLVRHIGLSNVTPTQVAEA------RKIAEivcvqN 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 152 QIELSpYLQNRKVVDWAKQQGIHITSYMTLAYGKALKDEVIARIAEKHNATAAQVILAWAI--GEGYAVIPSSTKRENLA 229
Cdd:PRK10376 187 HYNLA-HRADDALIDALARDGIAYVPFFPLGGFTPLQSSTLSDVAASLGATPMQVALAWLLqrSPNILLIPGTSSVAHLR 265
|
250
....*....|....
gi 550714234 230 SNLLAWDLQLDDED 243
Cdd:PRK10376 266 ENLAAAELVLSEEV 279
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
1-232 |
1.41e-17 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 80.44 E-value: 1.41e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTFRL-----KDDVVIASVKTALELGYRAIDTAQIY---DNEAAVGQA----IEESGVPRHELFITTKI--- 65
Cdd:cd19099 1 LTLSSLGLGTYRGdsddeTDEEYREALKAALDSGINVIDTAINYrggRSERLIGKAlrelIEKGGIKRDEVVIVTKAgyi 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 66 ------------WIENLSKDKLIP------------------SLKESLKKLRTDYVDLTLIHWPSPG-DAFSVEEFMQAL 114
Cdd:cd19099 81 pgdgdeplrplkYLEEKLGRGLIDvadsaglrhcispayledQIERSLKRLGLDTIDLYLLHNPEEQlLELGEEEFYDRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 115 LEA-------KEQGLTREIGISNFTIP----------LMEKAIAAVGKENIATN-----QIELSPYLQ------------ 160
Cdd:cd19099 161 EEAfealeeaVAEGKIRYYGISTWDGFrappalpghlSLEKLVAAAEEVGGDNHhfkviQLPLNLLEPealtekntvkge 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 550714234 161 NRKVVDWAKQQGIHITSYMTLAYGKALKDEVIARIAEKHNA-TAAQVILAWAIGE-GY-AVIPSSTKRENLASNL 232
Cdd:cd19099 241 ALSLLEAAKELGLGVIASRPLNQGQLLGELRLADLLALPGGaTLAQRALQFARSTpGVdSALVGMRRPEHVDENL 315
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
1-140 |
3.48e-17 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 79.13 E-value: 3.48e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGT------FRLKDDV-VIASVKTALELGYRAIDTAQIYDN---EAAVGQAIeeSGVPRHELFITTKI----- 65
Cdd:cd19163 11 LKVSKLGFGAsplggvFGPVDEEeAIRTVHEALDSGINYIDTAPWYGQgrsETVLGKAL--KGIPRDSYYLATKVgrygl 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 66 -WIE--NLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGDAFS--VEEFMQALLEAKEQGLTREIGISNFTIPLMEKAI 140
Cdd:cd19163 89 dPDKmfDFSAERITKSVEESLKRLGLDYIDIIQVHDIEFAPSLDqiLNETLPALQKLKEEGKVRFIGITGYPLDVLKEVL 168
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
2-142 |
6.63e-17 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 78.47 E-value: 6.63e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 2 TIPAL--GLGTF--RLKDDV----VIASVKTALELGYRAIDTAQIY-DNEAAVGQAIE--ESGVPRHELFITTK-----I 65
Cdd:cd19164 12 GLPPLifGAATFsyQYTTDPesipPVDIVRRALELGIRAFDTSPYYgPSEIILGRALKalRDEFPRDTYFIITKvgrygP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 66 WIENLSKDKLIPSLKESLKKLRTDYVDLTLIHwpspgDA-F-SVEEFMQA---LLEAKEQGLTREIGISNFTIP-LMEKA 139
Cdd:cd19164 92 DDFDYSPEWIRASVERSLRRLHTDYLDLVYLH-----DVeFvADEEVLEAlkeLFKLKDEGKIRNVGISGYPLPvLLRLA 166
|
...
gi 550714234 140 IAA 142
Cdd:cd19164 167 ELA 169
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
3-243 |
1.04e-16 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 78.07 E-value: 1.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDD-----VVIASVKTALELGYRAIDTAQIYDN-----EAAVGQAIEESGVP-RHELFITTKIWIENL- 70
Cdd:cd19089 11 LPAISLGLWHNFGDytspeEARELLRTAFDLGITHFDLANNYGPppgsaEENFGRILKRDLRPyRDELVISTKAGYGMWp 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 71 -------SKDKLIPSLKESLKKLRTDYVDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAV 143
Cdd:cd19089 91 gpygdggSRKYLLASLDQSLKRMGLDYVDIFYHHRYDP--DTPLEETMTALADAVRSGKALYVGISNYPGAKARRAIALL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 144 G--KENIATNQIELSpyLQNR----KVVDWAKQQGIHITSYMTLAYG-------------------------------KA 186
Cdd:cd19089 169 RelGVPLIIHQPRYS--LLDRwaedGLLEVLEEAGIGFIAFSPLAQGlltdkylngippdsrraaeskflteealtpeKL 246
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 187 LKDEVIARIAEKHNATAAQVILAWAIGEGY--AVIPSSTKRENLASNLLAWD-LQLDDED 243
Cdd:cd19089 247 EQLRKLNKIAAKRGQSLAQLALSWVLRDPRvtSVLIGASSPSQLEDNVAALKnLDFSEEE 306
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
5-247 |
3.29e-16 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 76.87 E-value: 3.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 5 ALGLG---TF--RLKDDVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIEESGVPRHELFITTKI-W-----IEN- 69
Cdd:cd19143 15 ALSFGswvTFgnQVDVDEAKECMKAAYDAGVNFFDNAEVYANgqsEEIMGQAIKELGWPRSDYVVSTKIfWggggpPPNd 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 70 --LSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPgdAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKEN 147
Cdd:cd19143 95 rgLSRKHIVEGTKASLKRLQLDYVDLVFCHRPDP--ATPIEETVRAMNDLIDQGKAFYWGTSEWSAQQIEEAHEIADRLG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 148 IATNQIELSPY--LQNRKV-VDWA---KQQGIHITSYMTLAYG---------------------KALKDEV--------- 191
Cdd:cd19143 173 LIPPVMEQPQYnlFHRERVeVEYAplyEKYGLGTTTWSPLASGlltgkynngipegsrlalpgyEWLKDRKeelgqekie 252
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550714234 192 ----IARIAEKHNATAAQVILAWAIGEGY--AVIPSSTKRENLASNLLAWDL--QLDDEDKKAI 247
Cdd:cd19143 253 kvrkLKPIAEELGCSLAQLAIAWCLKNPNvsTVITGATKVEQLEENLKALEVlpKLTPEVMEKI 316
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
6-132 |
3.66e-16 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 76.44 E-value: 3.66e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 6 LGLGTF-----RLKDDVVIASVKTALELGYRAIDTAQIY---DNEAAVGQAieesGVPRHELFITTKI--WIEN-LSKDK 74
Cdd:cd19075 5 LGTMTFgsqgrFTTAEAAAELLDAFLERGHTEIDTARVYpdgTSEELLGEL----GLGERGFKIDTKAnpGVGGgLSPEN 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 550714234 75 LIPSLKESLKKLRTDYVDLTLIHwpSPGDAFSVEEFMQALLEAKEQGLTREIGISNFT 132
Cdd:cd19075 81 VRKQLETSLKRLKVDKVDVFYLH--APDRSTPLEETLAAIDELYKEGKFKEFGLSNYS 136
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
25-250 |
3.97e-16 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 76.45 E-value: 3.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 25 ALELGYRAIDTAQIY----------DNEAAVGQAIEESGvPRHELFITTKI--------WI----ENLSKDKLIPSLKES 82
Cdd:cd19094 27 AFDEGVNFIDTAEMYpvppspetqgRTEEIIGSWLKKKG-NRDKVVLATKVagpgegitWPrgggTRLDRENIREAVEGS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 83 LKKLRTDYVDLTLIHWPS----------------PGDAFSVEEFMQALLEAKEQGLTREIGISNFTiP--LME--KAIAA 142
Cdd:cd19094 106 LKRLGTDYIDLYQLHWPDrytplfgggyytepseEEDSVSFEEQLEALGELVKAGKIRHIGLSNET-PwgVMKflELAEQ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 143 VGKENIATNQIELSpyLQNRK-VVDWAKQ---QGIHITSYMTLAYG----KALKDEV---IAR----------------- 194
Cdd:cd19094 185 LGLPRIVSIQNPYS--LLNRNfEEGLAEAchrENVGLLAYSPLAGGvltgKYLDGAArpeGGRlnlfpgymaryrspqal 262
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550714234 195 --------IAEKHNATAAQVILAWAIGEGY--AVIPSSTKRENLASNLLAWDLQLDDEDKKAIAAL 250
Cdd:cd19094 263 eavaeyvkLARKHGLSPAQLALAWVRSRPFvtSTIIGATTLEQLKENIDAFDVPLSDELLAEIDAV 328
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
5-247 |
1.44e-15 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 74.78 E-value: 1.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 5 ALGLGTFRLK--------DDVVIASVKTALELGYRAIDTAQIY---DNEAAVGQAIEesGVPRHELFITTKIWIENLSKD 73
Cdd:cd19145 14 AQGLGCMGLSgdygapkpEEEGIALIHHAFNSGVTFLDTSDIYgpnTNEVLLGKALK--DGPREKVQLATKFGIHEIGGS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 74 KLI---------PSLKESLKKLRTDYVDLTLIHwpSPGDAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAvg 144
Cdd:cd19145 92 GVEvrgdpayvrAACEASLKRLDVDYIDLYYQH--RIDTTVPIEITMGELKKLVEEGKIKYIGLSEASADTIRRAHAV-- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 145 kENIATNQIELSPYLQN--RKVVDWAKQQGIHITSYMTLAYG----KALKDEV--------------------------- 191
Cdd:cd19145 168 -HPITAVQLEWSLWTRDieEEIIPTCRELGIGIVPYSPLGRGffagKAKLEELlensdvrkshprfqgenleknkvlyer 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 550714234 192 IARIAEKHNATAAQVILAWAIGEGYAV--IPSSTKRENLASNLLAWDLQLDDEDKKAI 247
Cdd:cd19145 247 VEALAKKKGCTPAQLALAWVLHQGEDVvpIPGTTKIKNLNQNIGALSVKLTKEDLKEI 304
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
6-141 |
5.64e-15 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 72.56 E-value: 5.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 6 LGLGT--F-----------RLKDDVVIASVKTALELGYRAIDTAQIY-DNEAAVGQAIEESgvprHELFITTKI----WI 67
Cdd:cd19097 3 LALGTaqFgldygianksgKPSEKEAKKILEYALKAGINTLDTAPAYgDSEKVLGKFLKRL----DKFKIITKLpplkED 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 550714234 68 ENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSpgDAFSV-EEFMQALLEAKEQGLTREIGISNFTIPLMEKAIA 141
Cdd:cd19097 79 KKEDEAAIEASVEASLKRLKVDSLDGLLLHNPD--DLLKHgGKLVEALLELKKEGLIRKIGVSVYSPEELEKALE 151
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-129 |
6.18e-15 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 73.07 E-value: 6.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 14 KDDVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIeeSGVPrHELFITTKIWIENLS----KDKLIPSLKESLKKL 86
Cdd:cd19104 30 TREEQIAAVRRALDLGINFFDTAPSYGDgksEENLGRAL--KGLP-AGPYITTKVRLDPDDlgdiGGQIERSVEKSLKRL 106
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 550714234 87 RTDYVDLTLIH-------------WPSPGDAFSVEEFMQALLEAKEQGLTREIGIS 129
Cdd:cd19104 107 KRDSVDLLQLHnrigderdkpvggTLSTTDVLGLGGVADAFERLRSEGKIRFIGIT 162
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
1-234 |
3.95e-13 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 68.14 E-value: 3.95e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTF-----RLKDDVVIASVKTALELGYRAIDTAQIY---DNEAAVGQAIEESGVPRHELFITTKIWI----- 67
Cdd:cd19159 11 LRVSCLGLGTWvtfggQISDEVAERLMTIAYESGVNLFDTAEVYaagKAEVILGSIIKKKGWRRSSLVITTKLYWggkae 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 68 --ENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGDafSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGK 145
Cdd:cd19159 91 teRGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNT--PMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 146 ENIATNQIELSPY--LQNRKV---------------VDWAK----------QQGIHITSYMTLAYGKALKDEVIAR---- 194
Cdd:cd19159 169 FNMIPPVCEQAEYhlFQREKVevqlpelyhkigvgaMTWSPlacgiisgkyGNGVPESSRASLKCYQWLKERIVSEegrk 248
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 550714234 195 ----------IAEKHNATAAQVILAWAI-GEGY-AVIPSSTKRENLASNLLA 234
Cdd:cd19159 249 qqnklkdlspIAERLGCTLPQLAVAWCLrNEGVsSVLLGSSTPEQLIENLGA 300
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
13-184 |
4.92e-13 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 67.50 E-value: 4.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 13 LKDDVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIEESGVPRHELFITTKI--WIE--NLSKDKLIPSLKESLKK 85
Cdd:PLN02587 28 VSEEDAIASVREAFRLGINFFDTSPYYGGtlsEKVLGKALKALGIPREKYVVSTKCgrYGEgfDFSAERVTKSVDESLAR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 86 LRTDYVDLTLIHWPSPGDAFS-VEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGKENIA------------TNQ 152
Cdd:PLN02587 108 LQLDYVDILHCHDIEFGSLDQiVNETIPALQKLKESGKVRFIGITGLPLAIFTYVLDRVPPGTVDvilsychyslndSSL 187
|
170 180 190
....*....|....*....|....*....|..
gi 550714234 153 IELSPYLqnrkvvdwaKQQGIHITSYMTLAYG 184
Cdd:PLN02587 188 EDLLPYL---------KSKGVGVISASPLAMG 210
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
4-129 |
2.71e-12 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 65.46 E-value: 2.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 4 PALGLGT------FRLKDDVVIASVKTALELGYRAIDTAQIY---DNEAAVGQAIeeSGVPRHELFITTKI--------- 65
Cdd:cd19162 1 PRLGLGAaslgnlARAGEDEAAATLDAAWDAGIRYFDTAPLYglgLSERRLGAAL--ARHPRAEYVVSTKVgrllepgaa 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550714234 66 -------WIENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGDAFSVEEFMQALLEAKEQGLTREIGIS 129
Cdd:cd19162 79 grpagadRRFDFSADGIRRSIEASLERLGLDRLDLVFLHDPDRHLLQALTDAFPALEELRAEGVVGAIGVG 149
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
1-251 |
3.33e-11 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 62.56 E-value: 3.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTFRLKDDVVIASVKTALEL----GYRAIDTAQIYD----------NEAAVGQAIEESGvPRHELFITTKIW 66
Cdd:PRK10625 11 LEVSTLGLGTMTFGEQNSEADAHAQLDYavaqGINLIDVAEMYPvpprpetqglTETYIGNWLAKRG-SREKLIIASKVS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 67 IENLSKDKLI------------PSLKESLKKLRTDYVDLTLIHWPS-PGDAF--------------SVEEFMQALLEAKE 119
Cdd:PRK10625 90 GPSRNNDKGIrpnqaldrknirEALHDSLKRLQTDYLDLYQVHWPQrPTNCFgklgyswtdsapavSLLETLDALAEQQR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 120 QGLTREIGISNFTIPLMEKAIAAVGKEN---IATNQielSPY-LQNRK----VVDWAKQQGIHITSYMTLAY----GKAL 187
Cdd:PRK10625 170 AGKIRYIGVSNETAFGVMRYLHLAEKHDlprIVTIQ---NPYsLLNRSfevgLAEVSQYEGVELLAYSCLAFgtltGKYL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 188 --------KDEVIAR------------------IAEKHNATAAQVILAWAIGEGY--AVIPSSTKRENLASNLLAWDLQL 239
Cdd:PRK10625 247 ngakpagaRNTLFSRftrysgeqtqkavaayvdIAKRHGLDPAQMALAFVRRQPFvaSTLLGATTMEQLKTNIESLHLTL 326
|
330
....*....|..
gi 550714234 240 DDEdkkAIAALE 251
Cdd:PRK10625 327 SEE---VLAEIE 335
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
3-234 |
3.34e-11 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 62.46 E-value: 3.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTF-----RLKDDVVIASVKTALELGYRAIDTAQIYDNEAA---VGQAIEESGVPRHELFITTKI-W---IEN- 69
Cdd:cd19141 12 VSCLGLGTWvtfgsQISDEVAEELVTLAYENGINLFDTAEVYAAGKAeivLGKILKKKGWRRSSYVITTKIfWggkAETe 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 70 --LSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGDafSVEEFMQALLEAKEQGLTREIGISNFT-IPLMEkAIAAVGKE 146
Cdd:cd19141 92 rgLSRKHIIEGLKASLERLQLEYVDIVFANRPDPNT--PMEEIVRAFTHVINQGMAMYWGTSRWSaMEIME-AYSVARQF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 147 NIATNQIELSPY--LQNRKV---------------VDWAKQ----------QGIHITSYMTLAYGKALKDEVIAR----- 194
Cdd:cd19141 169 NLIPPIVEQAEYhlFQREKVemqlpelfhkigvgaMTWSPLacgilsgkydDGVPEYSRASLKGYQWLKEKILSEegrrq 248
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 550714234 195 ---------IAEKHNATAAQVILAWAI-GEG-YAVIPSSTKRENLASNLLA 234
Cdd:cd19141 249 qaklkelqiIADRLGCTLPQLAIAWCLkNEGvSSVLLGASSTEQLYENLQA 299
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
33-247 |
8.45e-11 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 61.29 E-value: 8.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 33 IDTAQIY---DNEAAVGQAIEESGVpRHELFITTK--IWIENLSKDK------------LIPSLKESLKKLRTDYVDLTL 95
Cdd:cd19146 52 IDTANNYqgeESERWVGEWMASRGN-RDEMVLATKytTGYRRGGPIKiksnyqgnhaksLRLSVEASLKKLQTSYIDILY 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 96 IHWpspGD-AFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAV------------GKENIATNQIElspylqnR 162
Cdd:cd19146 131 VHW---WDyTTSIPELMQSLNHLVAAGKVLYLGVSDTPAWVVSKANAYArahgltqfvvyqGHWSAAFRDFE-------R 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 163 KVVDWAKQQGIHITSYMTLAYGKALKDE------------------------VIARIAEKHNATAAQVILAWAIGEGYAV 218
Cdd:cd19146 201 DILPMCEAEGMALAPWGVLGQGQFRTEEefkrrgrsgrkggpqtekerkvseKLEKVAEEKGTAITSVALAYVMHKAPYV 280
|
250 260 270
....*....|....*....|....*....|.
gi 550714234 219 IP--SSTKRENLASNLLAWDLQLDDEDKKAI 247
Cdd:cd19146 281 FPivGGRKVEHLKGNIEALGISLSDEEIQEI 311
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
1-234 |
2.13e-10 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 60.10 E-value: 2.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTF-----RLKDDVVIASVKTALELGYRAIDTAQIY---DNEAAVGQAIEESGVPRHELFITTKIWI----- 67
Cdd:cd19158 11 LRVSCLGLGTWvtfggQITDEMAEHLMTLAYDNGINLFDTAEVYaagKAEVVLGNIIKKKGWRRSSLVITTKIFWggkae 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 68 --ENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGDafSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGK 145
Cdd:cd19158 91 teRGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNT--PMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 146 ENIATNQIELSPY--LQNRKV---------------VDWAK----------QQGIHITSYMTLAYGKALKDEVIAR---- 194
Cdd:cd19158 169 FNLIPPICEQAEYhmFQREKVevqlpelfhkigvgaMTWSPlacgivsgkyDSGIPPYSRASLKGYQWLKDKILSEegrr 248
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 550714234 195 ----------IAEKHNATAAQVILAWAI-GEGY-AVIPSSTKRENLASNLLA 234
Cdd:cd19158 249 qqaklkelqaIAERLGCTLPQLAIAWCLrNEGVsSVLLGASNAEQLMENIGA 300
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
3-210 |
2.76e-10 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 59.72 E-value: 2.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFRLKDDVVI-----ASVKTALELGYRAIDTAQIY-----DNEAAVGQAIEESGVP-RHELFITTK----IWI 67
Cdd:cd19151 12 LPAISLGLWHNFGDVDRyensrAMLRRAFDLGITHFDLANNYgpppgSAEENFGRILKEDLKPyRDELIISTKagytMWP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 68 ----ENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGDafSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAV 143
Cdd:cd19151 92 gpygDWGSKKYLIASLDQSLKRMGLDYVDIFYHHRPDPET--PLEETMGALDQIVRQGKALYVGISNYPPEEAREAAAIL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 144 G--KENIATNQIELSpyLQNRKV----VDWAKQQGIHITSYMTLAYG----KALK---------------------DEVI 192
Cdd:cd19151 170 KdlGTPCLIHQPKYS--MFNRWVeeglLDVLEEEGIGCIAFSPLAQGlltdRYLNgipedsraakgssflkpeqitEEKL 247
|
250 260
....*....|....*....|....
gi 550714234 193 AR------IAEKHNATAAQVILAW 210
Cdd:cd19151 248 AKvrrlneIAQARGQKLAQMALAW 271
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
1-232 |
1.02e-09 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 58.07 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLGTF-----RLKDDVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIEESGVPRHELFITTKIWI----- 67
Cdd:cd19160 13 LRVSCLGLGTWvtfgsQISDETAEDLLTVAYEHGVNLFDTAEVYAAgkaERTLGNILKSKGWRRSSYVVTTKIYWggqae 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 68 --ENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGDafSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAVGK 145
Cdd:cd19160 93 teRGLSRKHIIEGLRGSLDRLQLEYVDIVFANRSDPNS--PMEEIVRAMTYVINQGMAMYWGTSRWSAMEIMEAYSVARQ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 146 ENIATNQIELSPY--LQNRKV----VDWAKQQGIHITSYMTLAYG---------------------KALKDEVIAR---- 194
Cdd:cd19160 171 FNLIPPVCEQAEYhlFQREKVemqlPELYHKIGVGSVTWSPLACGlitgkydgrvpdtcraavkgyQWLKEKVQSEegkk 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 550714234 195 ----------IAEKHNATAAQVILAWAI-GEGY-AVIPSSTKRENLASNL 232
Cdd:cd19160 251 qqakvkelhpIADRLGCTVAQLAIAWCLrSEGVsSVLLGVSSAEQLIENL 300
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
3-97 |
1.04e-09 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 57.86 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTF-----RLKDDVVIASVKTALELGYRAIDTAQIYDNEAA---VGQAIEESGVPRHELFITTKIWIEN----- 69
Cdd:cd19142 13 VSNVGLGTWstfstAISEEQAEEIVTLAYENGINYFDTSDAFTSGQAeteLGRILKKKGWKRSSYIVSTKIYWSYgseer 92
|
90 100
....*....|....*....|....*....
gi 550714234 70 -LSKDKLIPSLKESLKKLRTDYVDLTLIH 97
Cdd:cd19142 93 gLSRKHIIESVRASLRRLQLDYIDIVIIH 121
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
4-232 |
5.24e-09 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 55.69 E-value: 5.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 4 PALGLGT------FR-LKDDVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIeeSGVPRHELFITTKI-WI----- 67
Cdd:cd19152 1 PKLGFGTaplgnlYEaVSDEEAKATLVAAWDLGIRYFDTAPWYGAglsEERLGAAL--RELGREDYVISTKVgRLlvplq 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 68 -------------------ENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGDAF--SVEEFMQALLEA-------KE 119
Cdd:cd19152 79 eveptfepgfwnplpfdavFDYSYDGILRSIEDSLQRLGLSRIDLLSIHDPDEDLAGaeSDEHFAQAIKGAfraleelRE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 120 QGLTREIGI-SNFTIPLMEkaIAAVGKENIA-----------TNQIELSPYLQNRKVvdwakqqGIHI------------ 175
Cdd:cd19152 159 EGVIKAIGLgVNDWEVILR--ILEEADLDWVmlagrytlldhSAARELLPECEKRGV-------KVVNagpfnsgflagg 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550714234 176 TSYMTLAYGKAlKDEVIAR------IAEKHN---ATAA-QVILAWAIGEgyAVIPSSTKRENLASNL 232
Cdd:cd19152 230 DNFDYYEYGPA-PPELIARrdrieaLCEQHGvslAAAAlQFALAPPAVA--SVAPGASSPERVEENV 293
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
27-251 |
8.10e-09 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 55.22 E-value: 8.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 27 ELGYRAIDTAQIYDNEAA---VGQAIEESGVpRHELFITTKIWIENLS---------------KDKLIPSLKESLKKLRT 88
Cdd:cd19147 45 EAGGNFIDTANNYQDEQSetwIGEWMKSRKN-RDQIVIATKFTTDYKAyevgkgkavnycgnhKRSLHVSVRDSLRKLQT 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 89 DYVDLTLIHWpspGD-AFSVEEFMQALLEAKEQGLTREIGIS----------NFTIPLMEKAIAAV--GKENIATNQIE- 154
Cdd:cd19147 124 DWIDILYVHW---WDyTTSIEEVMDSLHILVQQGKVLYLGVSdtpawvvsaaNYYATAHGKTPFSVyqGRWNVLNRDFEr 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 155 ------------LSPY-------LQNRKVVDWAKQQGIHITSYMTLAYGKALK---DEVIARIAEKHN-ATAAQVILAWA 211
Cdd:cd19147 201 diipmarhfgmaLAPWdvlgggkFQSKKAVEERKKNGEGLRSFVGGTEQTPEEvkiSEALEKVAEEHGtESVTAIALAYV 280
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 550714234 212 IGEGYAVIPS--STKRENLASNLLAWDLQLDDEDkkaIAALE 251
Cdd:cd19147 281 RSKAPNVFPLvgGRKIEHLKDNIEALSIKLTPEE---IEYLE 319
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
4-128 |
1.84e-08 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 54.25 E-value: 1.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 4 PALGLGTFRL-------KDDVVIASVKTALELGYRAIDTAQIYDN---EAAVGQAIEEsgVPRHELFITTKI-------- 65
Cdd:cd19161 1 SELGLGTAGLgnlytavSNADADATLDAAWDSGIRYFDTAPMYGHglaEHRLGDFLRE--KPRDEFVLSTKVgrllkpar 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 66 ---------WIENL--------SKDKLIPSLKESLKKLRTDYVDLTLIHWPSP---GDAFSVEEFMQ-------ALLEAK 118
Cdd:cd19161 79 egsvpdpngFVDPLpfeivydySYDGIMRSFEDSLQRLGLNRIDILYVHDIGVythGDRKERHHFAQlmsggfkALEELK 158
|
170
....*....|
gi 550714234 119 EQGLTREIGI 128
Cdd:cd19161 159 KAGVIKAFGL 168
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
3-236 |
2.17e-07 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 50.92 E-value: 2.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 3 IPALGLGTFR-LKDDVVIAS----VKTALELGYRAIDTAQIY-----DNEAAVGQAIEESGVP-RHELFITTK----IWI 67
Cdd:cd19150 12 LPALSLGLWHnFGDDTPLETqraiLRTAFDLGITHFDLANNYgpppgSAEENFGRILREDFAGyRDELIISTKagydMWP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 68 ----ENLSKDKLIPSLKESLKKLRTDYVDLTLIHWPSPGDafSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIAAV 143
Cdd:cd19150 92 gpygEWGSRKYLLASLDQSLKRMGLDYVDIFYSHRFDPDT--PLEETMGALDHAVRSGKALYVGISSYSPERTREAAAIL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 144 GKENIATNQIELSPYLQNRKV-----VDWAKQQGIHITSYMTLAYG------------------------KALKDEVIAR 194
Cdd:cd19150 170 RELGTPLLIHQPSYNMLNRWVeesglLDTLQELGVGCIAFTPLAQGlltdkylngipegsraskerslspKMLTEANLNS 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 550714234 195 ------IAEKHNATAAQVILAWAIGEG---YAVIPSStKRENLASNLLAWD 236
Cdd:cd19150 250 iralneIAQKRGQSLAQMALAWVLRDGrvtSALIGAS-RPEQLEENVGALD 299
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
1-247 |
1.76e-06 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 48.45 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 1 MTIPALGLG-----TFRLKDDVVIASVKTALELGYRAIDTAQIY-----DNEAAVGQAIEESGVP-RHELFITTK----I 65
Cdd:PRK09912 23 LRLPALSLGlwhnfGHVNALESQRAILRKAFDLGITHFDLANNYgpppgSAEENFGRLLREDFAAyRDELIISTKagydM 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 66 WI----ENLSKDKLIPSLKESLKKLRTDYVDLTLIHwpSPGDAFSVEEFMQALLEAKEQGLTREIGISNFTIPLMEKAIA 141
Cdd:PRK09912 103 WPgpygSGGSRKYLLASLDQSLKRMGLEYVDIFYSH--RVDENTPMEETASALAHAVQSGKALYVGISSYSPERTQKMVE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714234 142 AVGKENIATNQIELSPYLQNRKV-----VDWAKQQGIHITSYMTLAYG-----------------------KALKDEVIA 193
Cdd:PRK09912 181 LLREWKIPLLIHQPSYNLLNRWVdksglLDTLQNNGVGCIAFTPLAQGlltgkylngipqdsrmhregnkvRGLTPKMLT 260
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550714234 194 -----------RIAEKHNATAAQVILAWAIGEG--YAVIPSSTKRENLASNLLAW-DLQLDDEDKKAI 247
Cdd:PRK09912 261 eanlnslrllnEMAQQRGQSMAQMALSWLLKDErvTSVLIGASRAEQLEENVQALnNLTFSTEELAQI 328
|
|
| |
