|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
1-407 |
0e+00 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 546.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 1 MNQKSWLLNLSLLKTHPAYRAVFIARFISILSLGLLGVAVPVQIQTMTHSSWLVGLSVTLTGGAMFIGLMVGGVLADRYE 80
Cdd:PRK10489 1 MNKQSWLLDLSLLKTHPAFRAVFIARFISIFGLGLLGVAVPVQIQMMTGSTLQVGLSVTLTGGAMFIGLMVGGVLADRYD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 81 RKKLILLARGTCGVGFVGLCLNAMLPEPSLVAIYVLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSV 160
Cdd:PRK10489 81 RKKLILLARGTCGLGFIGLALNAFLPEPSLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 161 ISPMVGGLLLATGNVAWNYGLAAAGTFITTLTLLRLPLLPPPPQPREHPLKSLMAAIRFLFSNPLIGGIALLGGLLTMAS 240
Cdd:PRK10489 161 ISPALGGLLIAAGGVAWNYGLAAAGTFITLLPLLRLPALPPPPQPREHPLRSLLAGFRFLLASPVVGGIALLGGLLTMAS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 241 AVRVLYPALAGE-WQMSASEIGVLYAAIPLGAAFGALTSGNLAQSARPGLIMLVATLASFIAIGFFSLMPVWALGVMCLV 319
Cdd:PRK10489 241 AVRVLYPALADEvWQMGAAQIGLLYAAVPLGAALGALTSGWLAHSARPGLLMLLSTLGSFLAVGLFGLMPMWILAVLCLA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 320 IFGWLSAVSSLLQYTLIQTQTPEGMLGRINGLWTAQNVTGDAIGAAILGGLGAIMTPVASASSSGFVLAVVGVILLAVLV 399
Cdd:PRK10489 321 LFGYLSAISSLLQYTLLQTQTPDEMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPVASASASGFGLLIIGVLLLLVLG 400
|
....*...
gi 550714490 400 ELRRFRQT 407
Cdd:PRK10489 401 ELRRFRQT 408
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
19-395 |
3.13e-39 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 144.30 E-value: 3.13e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 19 YRAVFIARFISILSLGLLGVAVPVQIQTMTHSSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILLARGTCGVGFVG 98
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 99 LCLNAMLPEPSLVAIYVLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMVGGLLLATGNVAWN 178
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 179 YGLAAAGTFITTLTLLRLPLLPPPPQPREHPLK--SLMAAIRFLFSNPL-IGGIALLGGLLTMASAVRVLYPALAGE-WQ 254
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPGESSSLLlrDLREGLRYLRRSPLlRLLLLALALFALLGGALTVLLPLLAKEvLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 255 MSASEIGVLYAAIPLGAAFGALTSGNLAQSARPGLIMLVATLASFIAIGFFSLMPVWALGVMCLVIFGWLSAVSSLLQYT 334
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550714490 335 LIQTQTPEGMLGRINGLWTAQNVTGDAIGAAILGGLGAIMTPVASASSSGFVLAVVGVILL 395
Cdd:cd06173 321 LLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLL 381
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-354 |
6.61e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 78.48 E-value: 6.61e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 21 AVFIARFISILSLGLLGVAVPVQIQTMTHSSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILLARGTCGVGFVGLC 100
Cdd:COG2814 14 ALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 101 LNamlpePSLVAIYVLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMVGGLLLATGNVAWNYG 180
Cdd:COG2814 94 LA-----PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 181 LAAAGTFITTLTLLRLPLLPPppqprEHPLKSLMAAIRFLFSNPLIGGIALLGGLLTMASAVRVLY--PALAGEWQMSAS 258
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESR-----PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYlpLYLQEVLGLSAS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 259 EIGVLYAAIPLGAAFGALTSGNLAQSARPGLIMLVATLASFIAIGFFSLMPVWALGVMCLVIFGWLSAVSSLLQYTLIQT 338
Cdd:COG2814 244 AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE 323
|
330
....*....|....*.
gi 550714490 339 QTPEGMLGRINGLWTA 354
Cdd:COG2814 324 LAPPEARGRASGLYNS 339
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
16-405 |
3.07e-13 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 71.32 E-value: 3.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 16 HPAYRAVFIARFISILSLGLLGVAVPVQIQTMTHSSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILLARGTCGVG 95
Cdd:pfam05977 9 QGVFRVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 96 FVGLCLNAMLPEPSLVAIYVLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMVGGLLLATGNV 175
Cdd:pfam05977 89 STLLTLLAGLGLLSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 176 AWNYGLAAAGTF-ITTLTLLRLPLLPPPPQPREHPLKSLMAAIRFL-FSNPLIGGIALLGGLLTMASAVRVLYPALA-GE 252
Cdd:pfam05977 169 AFTFALNALSYFaVIAALWRWKRAAPASPLPRERIFGAVRAGLRFTaMSRELRSVLVRAFAFGLSASAVWALLPLVArDL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 253 WQMSASEIGVLYAAIPLGAAFGALTSGNLAQS-ARPGLIMLVATLASFIAIGFFSLMPVW-ALGVMCLVIFGWLSAVSSL 330
Cdd:pfam05977 249 LDGDAIFYGILLGAVGVGAILGALSLPRLRERlGSDRLVLLASVVTALVLLSLALAPNLWlAIPVLLLGGAAWITALTTL 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 550714490 331 lqYTLIQTQTPEGMLGRINGLWTAQNVTGDAIGAAILGGlgaimtpVASASSSGFVLAVVGVILLAVLVELRRFR 405
Cdd:pfam05977 329 --NVAVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGA-------VAEALSVTGALLGAAAALLAGAAAGLRFR 394
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-364 |
1.62e-11 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 65.13 E-value: 1.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 22 VFIARFISILSLGLLGVAVPVQIQTMTH-SSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILlargtCGVGFVGLC 100
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL-----IGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 101 LNAMLPEPSLVAIYVLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMVGGLLLATGNVAWNYG 180
Cdd:pfam07690 76 LLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 181 LAAAGTFITTLTLLRLP--LLPPPPQPREHPLKSLMAAIRFLFSNPLIGGIALLGGLLTMASAVRVLYPALAGEWQMSAS 258
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRppPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 259 EIGVLYAAIPLGAAFGALTSGNLAQ---SARPGLIMLVATLASFIAIGFFSLMPVWALGVMCLVIFGWLSAVSSLLQYTL 335
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDrlgRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315
|
330 340
....*....|....*....|....*....
gi 550714490 336 IQTQTPEGMLGRINGLWTAQNVTGDAIGA 364
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
22-395 |
1.75e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.21 E-value: 1.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 22 VFIARFISILSLGLLGVAVPVQIQTMTHSSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILLargtcGVGFVGLCL 101
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLL-----GLLLLAVST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 102 NAMLPEPSLVAIYVLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMVGGLLLATGNVAWNYGL 181
Cdd:cd17325 76 LLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 182 AAAGTFITTLTLLRLPLLPPPPQPREHPLKSLMAAIRFLFSNPlIGGIALLGGLLTMASAVRVLYPAL----AGEWQMSA 257
Cdd:cd17325 156 CAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRD-RRLLALFLAIFVLAFAFGALEPFLplyaAELGGLSP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 258 SEIGVLYAAIPLGAAFGALTSGNLAQSARPGLIMLVATLASFIAIGFFSLMPVWALGVMCLVIFGWLSAVSSLLQYTLIQ 337
Cdd:cd17325 235 AQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 550714490 338 TQTPEGMLGRINGLWTAQNVTGDAIGAAILGGLGAIMTPVASASSSGFVLAVVGVILL 395
Cdd:cd17325 315 DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
22-395 |
3.23e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 52.04 E-value: 3.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 22 VFIARFISILSLGLLGVAVPVQIQTMTHSSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILLARGTCGVGFVGLCL 101
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 102 NamlpePSLVAIYVLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMVGGLLLATGNVAWNYGL 181
Cdd:cd06174 81 A-----PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 182 AAAG-----TFITTLTLLRLPLLPPPPQPREHPLKSLMAAIRFLFSNPLIGGIALLGGLLTMA--SAVRVLYPALAGEWQ 254
Cdd:cd06174 156 LIAAalallAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAyySFSTLLPLFLLDLGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 255 MSASEIGVLYAAIPLGAAFGALTSGNLAQSARPGLIMLVATLASF-IAIGFFSLMPVWALGVMCLVIFGWLSAVSSLLQY 333
Cdd:cd06174 236 LSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMaLGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSF 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550714490 334 TLIQTQTPEGMLGRINGLWTAQNVTGDAIGAAILGGLGAIMTPVASASSSGFVLAVVGVILL 395
Cdd:cd06174 316 ALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-403 |
8.14e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 50.64 E-value: 8.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 21 AVFIARFISILSLGLLGVAVPVQIQTMTHSSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILLARGTCGVGFVGLC 100
Cdd:COG2271 14 LLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 101 LNamlpePSLVAIYVLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMVGGLLLATGNVAWNYG 180
Cdd:COG2271 94 FA-----TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 181 LAAAGTFITTltllrlpllppppqprehPLKSLMAAIRFLFSNPLIGGIALlgglltmasavrVLYPALAGEWQMSASEI 260
Cdd:COG2271 169 ILGLPGLLLA------------------LLRFWLLALAYFLVYFALYGFLT------------WLPTYLVEVRGLSLAQA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 261 GVLYAAIPLGAAFGALTSGNLAQ--SARPGLIMLVATLASFIAIGFFSLMPVWALGVMCLVIFGWLSAVSSLLQYTLIQT 338
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSDrlGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 550714490 339 QTPEGMLGRINGLWTAQNVTGDAIGAAILGGLGAIMTPVASASSSGFVLAVVGVILLAVLVELRR 403
Cdd:COG2271 299 LFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
4-184 |
2.61e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.11 E-value: 2.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 4 KSWLLNLSLLKTHPAYRAVFIARFISILSLGLLGVAVPVQIQ-TMTHSSWLVGLSVTLTGGAMFIGLMVGGVLADRYERK 82
Cdd:cd17325 186 ARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAeLGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRK 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 83 KLILLargtcGVGFVGLCLNAMLPEPSLVAIYVLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVIS 162
Cdd:cd17325 266 PLILI-----GLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
|
170 180
....*....|....*....|..
gi 550714490 163 PMVGGLLLATGNVAWNYGLAAA 184
Cdd:cd17325 341 PLLGGFLYDAFGFATPFLAAAA 362
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
20-398 |
8.99e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 47.61 E-value: 8.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 20 RAVFIARFISILSLGLLGVAVPVQIQTMTH-SSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILLARGTCGVGFVG 98
Cdd:cd17329 2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGlSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 99 LCLNAMLPEPSLVAIYVlglwdGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMVGGLLLATGNVAwn 178
Cdd:cd17329 82 LGFAHSPWLFAIALVLT-----GFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRL-- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 179 YGLAAAGTFITTLTLLRLPLLPPPPQPREHPLKSLMAAIRFLFSNPLIGGIALLGGLLTMASAVRVLYPALAGEWQM--S 256
Cdd:cd17329 155 LFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILglG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 257 ASEIGVLYAAIPLGAAFGALTSGNLAQSARPGLIMLVATLASFIAIGFFSLMPVWALGVMCLVIFGWLSAVSSLLQYTLI 336
Cdd:cd17329 235 ESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLV 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550714490 337 QTQTPEGMLGRINGLwtaqNVTGDAIGAAILGGLGAIMTPVASASSSGFVLAVVGVILLAVL 398
Cdd:cd17329 315 AALAPPDKRGSYMGF----YALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALL 372
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
21-303 |
2.37e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.96 E-value: 2.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 21 AVFIARFISILSLGLLGVAVPVQIQTMTHSSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILLARGTCGVGFVGLC 100
Cdd:COG0477 18 ALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 101 LNamlpePSLVAIYVLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMVGGLLLATGNVAWNYG 180
Cdd:COG0477 98 LA-----PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 181 LAAAGTFITTLTLLRLPLLPPPPQPREHPLKSLMAAIRFLFSNPLIGGIALLGGLLTMASAVRVLYPALAGEWQMSASEI 260
Cdd:COG0477 173 INAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLL 252
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 550714490 261 GVLYAAIPLGAAFGALTSGNLAQSARPGLIMLVATLASFIAIG 303
Cdd:COG0477 253 LLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
18-407 |
2.90e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.00 E-value: 2.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 18 AYRAVFIARFISILSLGLLGVAVPVQIQTMTHSSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILLARGTCGVGFV 97
Cdd:COG0738 9 ALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 98 GLCLNAMLPePSLVAIYVLGLWDGFFASlGVTALLAATPALVGRENLMQAGAITMltvrLGSVISPMVGGLLLATG-NVA 176
Cdd:COG0738 89 LFALAPSYP-LLLLALFLLGLGLGLLDV-AANPYVAALGPETAASRLNLLHAFFS----LGALLGPLLGGLLILLGlSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 177 WNYGLAAAGTFITTLTLLRLPLLPPPPQPREHPLKSLMAAIRFLFSNPLIGGIALLGGLLTMA--SAVRVLYPALAGEWQ 254
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAegAIGDWLPLYLKDVLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 255 MSASEIGVLYAAIPLGAAFGALTSGNLAQSARPGLIMLVATLASFIAIGFFSLMPVWALGVMCLVIFGWLSAvsslLQYT 334
Cdd:COG0738 243 LSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLS----LMFP 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550714490 335 LIQTQTPEGMLGRINGLWTAQNVTGDAIGAAILGGLGAIMTPVASASSSGFVLAVVGVILLAVLVELRRFRQT 407
Cdd:COG0738 319 TIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
21-396 |
4.45e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 45.25 E-value: 4.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 21 AVFIARFISILSLGLLGVAVPVQIQTMTHSSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILLARGTCGVGFVGLC 100
Cdd:cd17474 3 AVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 101 LNamlpePSLVAIYVLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMVGGLLlatGNVAWNYG 180
Cdd:cd17474 83 LS-----DSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL---AAISWRYP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 181 LAAAGTFITTLTLLRLPLLPPPPQPREHPLKSLMAAIRFLFSNPLIGGIALLGGLLTMA-SAVRVLYPALAG-EWQMSAS 258
Cdd:cd17474 155 FFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLyFAFLTYLPFLLElLYGISPI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 259 EIGVLYAAIPLGAAFGALTSGNLAQ----SARPGLIMLVATLASFIAIGFFSLMPVWalgVMCLVIFGWLSAVSSLLQYT 334
Cdd:cd17474 235 IIGLLFAGWSVLLALGSLFVGRLLKkrfgARRILVIGLLLYALSLLLLGFVPSLALL---LIAIVLFGLGLGLNLPLLTT 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550714490 335 LIQTQTPEGMLGRINGLWTAQNVTGDAIGAAILGGLGAIMTPVAsASSSGFVLAVVGVILLA 396
Cdd:cd17474 312 LVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSA-PFLVGAAIALAAAVLLA 372
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
50-394 |
6.15e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.85 E-value: 6.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 50 SSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILLArgtCGVGFVGLCLNAMLPEPSLVAIYVLGLwdGFFASLGVT 129
Cdd:cd17324 32 SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVL---LLLFILGNLLAALAPSFALLLLARALA--GLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 130 ALLAATPALVGRENLMQAGAITMLTVRLGSVISPMVGGLLLATGNVAWNYGLAAAGTFITTLTLLRLPLLPPPPqprEHP 209
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPK---KPG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 210 LKSLMAAIRFLFSNPLIGGIALLGGLLTMA--SAVRVLYPALAGEWQMSASEIGVLYAAIPLGAAFGALTSGNLAQSARP 287
Cdd:cd17324 184 SLGLLSSLLLLLRNPRLRLAYLITFLLFGGffALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 288 GLIMLVATLASFIAIGFFSLMPVWALGVMCLVIFGWLSAVSSLLQYTLIQTQTPEGmLGRINGLWTAQNVTGDAIGAAIl 367
Cdd:cd17324 264 RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAAL- 341
|
330 340
....*....|....*....|....*..
gi 550714490 368 GGLGAIMTPVASASSSGFVLAVVGVIL 394
Cdd:cd17324 342 GGLVLDHGGWAGVGWVGAALLLLALLL 368
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
54-397 |
1.46e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.74 E-value: 1.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 54 VGLSVTLTGGAMFIGLMVG-------GVLADRYE-----RKKLILLARGTCGVGFVGLCLNAMLPEPSLVAIYVLGLW-D 120
Cdd:COG2211 41 LGLSAALVGLILLVARLWDaitdpliGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLlL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 121 GFFASLGVTALLAATPALVGRENL-MQAGAITMLTVRLGSVISPMVGGLLLAT--GNVAWNYGLAAA-GTFITTLTLLRL 196
Cdd:COG2211 121 GLAYTLVNIPYSALGAELTPDYEErTRLSSWRFAFAGLGGLLASVLPPPLVAAfgGDAALGYRLTALiFAVLGLLAFLLT 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 197 PLLPPPPQPREHPLKSLMAAIRFLFSNPLIGGIALLGGLLTMASAVR--VLYPALAGEWQMSASEIGVLYAAIPLGAAFG 274
Cdd:COG2211 201 FFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVaaLLLYYFKYVLGLSAALVGLLLALYFLAALLG 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 275 ALTSGNLAQ--SARPGLIM-LVATLASFIAIGFFSLMPVWALGVMClVIFGWLSAVSSLLQYTLI-------QTQTPEGM 344
Cdd:COG2211 281 APLWPRLAKrfGKKKAFIIgLLLAALGLLLLFFLGPGNLWLLLVLA-ALAGIGLGAILVLPWAMLadvvdydEWKTGRRR 359
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 550714490 345 LGRINGLWTAQNVTGDAIGAAILGGLGAIMTPVASASSSGFVLAVVGVILLAV 397
Cdd:COG2211 360 EGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSALTGIRLLFFLL 412
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
22-397 |
3.62e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.20 E-value: 3.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 22 VFIARFISILSLGLLGVAVPVQIQTMTHSSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILlargtCGVGFVGLCL 101
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLL-----IGLLIFALAT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 102 NAMLPEPSLVAIYVLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMVGGLLLATGNVAWNYGL 181
Cdd:cd17489 76 LLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 182 AAAGTFITTLTLLRLPLLPPPPQPREHPLKSLMAAIRflfsNPLIGGIALLGGLLTMASAVRVLYPALAGEwQMSASEIG 261
Cdd:cd17489 156 AAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLV----EKKVLPPALILFLASIAYGAISTFLPLYAA-ERGISNAG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 262 VLYAAIPLGAAFGALTSGNLAQSARPGLIMLVATLASFIAIGFFSLMPVWALGVMCLVIFGW-LSAVSSLLQYTLIQTQT 340
Cdd:cd17489 231 LFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLgFGLLFPALQALAVDLVP 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 550714490 341 PEGmLGRINGLWTAQNVTGDAIGAAILGGLGAIMT-PVASASSSGFVLAVVGVILLAV 397
Cdd:cd17489 311 PHR-RGAANGTFFIFFDLGIGLGGLLLGLVAELFGyRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
22-395 |
4.25e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 4.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 22 VFIARFISILSLGLLGVAVP---VQIQTMTHSSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILLARGTCGVGFVG 98
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPfyvREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 99 LCLNamlpePSLVAIYVLGLWDGFFASlGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMVGGLLLATGNVAWN 178
Cdd:cd17330 81 LGLS-----RNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 179 YGLAAAGTFIttltllrlpllppppqprehplkSLMAAIRFLFSNPLIGGIALLGGLLTMASAVrVLYPALAGEWQMSAS 258
Cdd:cd17330 155 FLVAAALALL-----------------------NLVLVLFFLPPLRRLLLVYFLIALAFAGLES-VFSLFLKDRFGFSPS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 259 EIGVLYAAIPLGAAF-GALTSGNLAQSARPGLIMLVATLASFIAIGFFSLMPVWALGVMCLVIFGWLSAVSSLLQYTLIQ 337
Cdd:cd17330 211 QIGLLLALVGIAGILaQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLS 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 550714490 338 TQTPEGMLGRINGLWTAQNVTGDAIGAAILGGLGAIMTPVASASSSGFVLAVVGVILL 395
Cdd:cd17330 291 KSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLS 348
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
4-171 |
9.26e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.04 E-value: 9.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 4 KSWLLNLSLLKTHPAYRAVFIARFISILSLGLL-GVAVPVQIQTMTHSSWLVGLSVTLTGGAMFIGLMVGGVLADRYERK 82
Cdd:COG2211 215 VSLKESLKALLKNRPFLLLLLAYLLFFLALALVaALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKK 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 83 KLILLARGTCGVGFVGLclnAMLPEPSLVAIYVLglwdGFFASLGVTALLAATPALV-----------GRENLMQAGAIT 151
Cdd:COG2211 295 KAFIIGLLLAALGLLLL---FFLGPGNLWLLLVL----AALAGIGLGAILVLPWAMLadvvdydewktGRRREGLYFGIF 367
|
170 180
....*....|....*....|
gi 550714490 152 MLTVRLGSVISPMVGGLLLA 171
Cdd:COG2211 368 TFAIKLGQALAGALAGLLLA 387
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
21-403 |
1.50e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 40.63 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 21 AVFIARFISILSLGLLGVAVPVQIQTMTHSSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILLARGTCGVGFVGLC 100
Cdd:COG2223 9 LATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 101 LnamlpEPSLVAIYVLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMVGGLLLATGNVAWNYG 180
Cdd:COG2223 89 L-----AVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 181 LAAAGTFITTLTLLRLPLLPPPPQPREHplKSLMAAIRFLFSNPLIGGIALLGGLLTMA--SAVRVLYPALAGEWQMSAS 258
Cdd:COG2223 164 ILGILLLVVAVLAWLFLRDPPAGAAAAA--KASLRDQLEALRDPRFWLLSLLYFGTFGSfiGFSSWLPPYLVDQFGLSAA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 259 EIGVLYAAIPLGAAFGALTSGNLAQSARPGLIMLVATLASFIAIGFFSLMPV-WALGVMCLVIFGWLSAVSSLLQYTLIQ 337
Cdd:COG2223 242 TAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGsLWLFLVLFLLLGLALGGGNGAVFALVP 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550714490 338 TQTPEGMLGRINGLWTAQNVTGDAIGAAILGGLGAIMTPVASASSSGFVLAVVGVILLAVLVELRR 403
Cdd:COG2223 322 DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPR 387
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
214-407 |
2.52e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.57 E-value: 2.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 214 MAAIRFLFSNPLIGGIALLGGLLTMASAVRVLYPALAGEWQMSASEIGVLYAAIPLGAAFGALTSGNLAQSARPGLIMLV 293
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 294 ATLASFIAIGFFSLMPVWALGVMCLVIFGWLSAVSSLLQYTLIQTQTPEGMLGRINGLWTAQNVTGDAIGAAILGGLGAI 373
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190
....*....|....*....|....*....|....
gi 550714490 374 MTPVASASSSGFVLAVVGVILLAVLVELRRFRQT 407
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAARA 194
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
17-173 |
3.95e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.08 E-value: 3.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 17 PAYRAVFIARFISILSLGLLGVAVPVQIQTMTH-SSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILLARGTCGVG 95
Cdd:cd17321 168 RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGySPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVG 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 96 FVGLC-LNAMLPEPSLVAIYVL-GLWDGFFASLGVTALLAAtpalVGRENLMQAGAITMLTVRLGSVISPMVGGLLLATG 173
Cdd:cd17321 248 LLLLAlLGADSSVWLLLPGLVLlGLGLGLFATPLTNAALSS----VPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
34-395 |
4.56e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.08 E-value: 4.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 34 GLLGVAVPVQIQTMTHSSWLVGLSVTLTGGAMFIGLMVGGVLADRYERKKLILLArgtCGVGFVGLCLNAMLPEPSLVAI 113
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLG---PLLTGLGLSLLGFAPNYWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 114 YVlglwdgFFASLGVTALLAATPALVGR---ENLMQAGAITMLTVRLGSVISPMVGGLLLAT-GNVAWnyGLAAAGTFIT 189
Cdd:cd17478 90 LV------ALAGIGSAAFHPEGARLASQaagGRRGLAMSIFSVGGNLGFALGPLIAAALVALfGGLGL--LILLIIPGLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 190 TLTLLRLPLLPPPPQPREHPLKSLMAAIRFLFSNPLIGGIALLGGLLTMASAVRVLYPALAGEWQMSASEIGVLYAAIPL 269
Cdd:cd17478 162 VALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714490 270 GAAFGALTSGNLAQSARPGLIMLVATLASFIAIGFFSLMPVWALGVMcLVIFGWLSAVSSLLQYTLIQTQTPEGMlGRIN 349
Cdd:cd17478 242 AGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYIL-LVLAGFLLFASFPVTVVLAQELLPGNV-GLAS 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 550714490 350 GLWTAQNVTGDAIGAAILGGLGAIMTPVASASSSGFVLAVVGVILL 395
Cdd:cd17478 320 GLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| |
