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Conserved domains on  [gi|550714595|ref|WP_022647484|]
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MULTISPECIES: molybdenum-dependent transcriptional regulator [Enterobacter]

Protein Classification

molybdenum-dependent transcriptional regulator( domain architecture ID 11484868)

molybdenum-dependent DNA-binding transcriptional regulator represses the modABCD operon and activates the moaABCD and napFDAGHBC operons

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10676 PRK10676
DNA-binding transcriptional regulator ModE; Provisional
 1-262 1.08e-175

DNA-binding transcriptional regulator ModE; Provisional


:

Pssm-ID: 182640 [Multi-domain]  Cd Length: 263  Bit Score: 484.15  E-value: 1.08e-175
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714595   1 MQAEILLTLRLQQKLFADPRRIALLKQIEQTGSISQGAKNAGISYKSAWDAINDMNTLSEQTLVERATGGKGGGGAVLTR 80
Cdd:PRK10676   1 MQAEILLTLKLQQRLFADPRRISLLKQIALTGSISQGAKLAGISYKSAWDAINEMNQLSEHILVERATGGKGGGGAVLTR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714595  81 YGQRLIQLYDLLAQIQQKAFDVLsDDDNLPLDSLLGAISRFSLQTSARNQWFGTVTGRDHSQVQEHIEILLADGTTRLKA 160
Cdd:PRK10676  81 YGERLIQLYDLLAQIQQKAFDVL-DDDALPLDSLLAAISRFSLQTSARNQWFGTITARDHQQVQQHVDVLLADGKTRLKV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714595 161 AITAQSGQRLGLNEGQEVLVLLKAPWISITLNPEQAAEADNQLRGRISHIERGAEQCEVLMTLPDGQSLCATVPVNDATE 240
Cdd:PRK10676 160 AITAQSAERLGLDEGKEVLVLIKAPWVGITQDPAVAQAADNQLPGTISHIERGAEQSEVLMALPDGQTLCATVPNNEAAR 239

                        250       260
                 ....*....|....*....|....
gi 550714595 241 LD--EGAVVTAYFNADRVIIATLC 262
Cdd:PRK10676 240 LSlqQGDAVTAYFNADRVIIATLC 263
 
Name Accession Description Interval E-value
PRK10676 PRK10676
DNA-binding transcriptional regulator ModE; Provisional
 1-262 1.08e-175

DNA-binding transcriptional regulator ModE; Provisional


Pssm-ID: 182640 [Multi-domain]  Cd Length: 263  Bit Score: 484.15  E-value: 1.08e-175
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714595   1 MQAEILLTLRLQQKLFADPRRIALLKQIEQTGSISQGAKNAGISYKSAWDAINDMNTLSEQTLVERATGGKGGGGAVLTR 80
Cdd:PRK10676   1 MQAEILLTLKLQQRLFADPRRISLLKQIALTGSISQGAKLAGISYKSAWDAINEMNQLSEHILVERATGGKGGGGAVLTR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714595  81 YGQRLIQLYDLLAQIQQKAFDVLsDDDNLPLDSLLGAISRFSLQTSARNQWFGTVTGRDHSQVQEHIEILLADGTTRLKA 160
Cdd:PRK10676  81 YGERLIQLYDLLAQIQQKAFDVL-DDDALPLDSLLAAISRFSLQTSARNQWFGTITARDHQQVQQHVDVLLADGKTRLKV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714595 161 AITAQSGQRLGLNEGQEVLVLLKAPWISITLNPEQAAEADNQLRGRISHIERGAEQCEVLMTLPDGQSLCATVPVNDATE 240
Cdd:PRK10676 160 AITAQSAERLGLDEGKEVLVLIKAPWVGITQDPAVAQAADNQLPGTISHIERGAEQSEVLMALPDGQTLCATVPNNEAAR 239

                        250       260
                 ....*....|....*....|....
gi 550714595 241 LD--EGAVVTAYFNADRVIIATLC 262
Cdd:PRK10676 240 LSlqQGDAVTAYFNADRVIIATLC 263
ModE_repress TIGR00637
ModE molybdate transport repressor domain; ModE is a molybdate-activated repressor of the ...
 16-113 4.15e-41

ModE molybdate transport repressor domain; ModE is a molybdate-activated repressor of the molybdate transport operon in E. coli. It consists of the domain represented by this model and two tandem copies of mop-like domain, where Mop proteins are a family of 68-residue molybdenum-pterin binding proteins of Clostridium pasteurianum. This model also represents the full length of a pair of archaeal proteins that lack Mop-like domains. PSI-BLAST analysis shows similarity to helix-turn-helix regulatory proteins. [Regulatory functions, Other]


Pssm-ID: 273188 [Multi-domain]  Cd Length: 99  Bit Score: 136.80  E-value: 4.15e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714595   16 FADPRRIALLKQIEQTGSISQGAKNAGISYKSAWDAINDMNTLSEQTLVERATGGKGGGGAVLTRYGQRLIQLYDLLAQI 95
Cdd:TIGR00637   1 FADPRRVALLKAIARMGSISQAAKDAGISYKSAWDYIRAMNNLSGEPLVERATGGKGGGGAVLTEYGQRLIQLYDLLERI 80

                          90
                  ....*....|....*....
gi 550714595   96 QQKAFDVLSDDDNL-PLDS 113
Cdd:TIGR00637  81 LEKAFSVLEDEVVVkPLKA 99
MopI COG3585
Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];
124-262 1.97e-39

Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];


Pssm-ID: 442804 [Multi-domain]  Cd Length: 141  Bit Score: 134.05  E-value: 1.97e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714595 124 QTSARNQWFGTVTGRDHSQVQEHIEILLADGTTRLKAAITAQSGQRLGLNEGQEVLVLLKAPWISITLNPEQAAEADNQL 203
Cdd:COG3585    1 MTSSRNNQFGGVVSIIAGGVVNEVVLLLLGGGTIIAAITTASSAELLGLVGGKEVAALKKASVVILATDDAMKLSARNQL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550714595 204 RGRISHIERGAEQCEVLMTLPDGQSLCATVPVNDATELD--EGAVVTAYFNADRVIIATLC 262
Cdd:COG3585   81 KGTVTRIERGAVNSEVVLDLGGGTTLTAVITNESVEELGlkEGDEVTALFKASSVILAVDA 141
TOBE pfam03459
TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the ...
 199-256 2.27e-10

TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum and sulfate. Found in ABC transporters immediately after the ATPase domain.


Pssm-ID: 427310 [Multi-domain]  Cd Length: 60  Bit Score: 54.98  E-value: 2.27e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714595  199 ADNQLRGRISHIERGAEQCEVLMTLPDGQSLCATVPVNDATELD--EGAVVTAYFNADRV 256
Cdd:pfam03459   1 ARNQLPGTVTVIEPLGSEVEVRVDLGGGLTLTARITRDSAEELGlaPGDEVWALIKATKV 60
 
Name Accession Description Interval E-value
PRK10676 PRK10676
DNA-binding transcriptional regulator ModE; Provisional
 1-262 1.08e-175

DNA-binding transcriptional regulator ModE; Provisional


Pssm-ID: 182640 [Multi-domain]  Cd Length: 263  Bit Score: 484.15  E-value: 1.08e-175
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714595   1 MQAEILLTLRLQQKLFADPRRIALLKQIEQTGSISQGAKNAGISYKSAWDAINDMNTLSEQTLVERATGGKGGGGAVLTR 80
Cdd:PRK10676   1 MQAEILLTLKLQQRLFADPRRISLLKQIALTGSISQGAKLAGISYKSAWDAINEMNQLSEHILVERATGGKGGGGAVLTR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714595  81 YGQRLIQLYDLLAQIQQKAFDVLsDDDNLPLDSLLGAISRFSLQTSARNQWFGTVTGRDHSQVQEHIEILLADGTTRLKA 160
Cdd:PRK10676  81 YGERLIQLYDLLAQIQQKAFDVL-DDDALPLDSLLAAISRFSLQTSARNQWFGTITARDHQQVQQHVDVLLADGKTRLKV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714595 161 AITAQSGQRLGLNEGQEVLVLLKAPWISITLNPEQAAEADNQLRGRISHIERGAEQCEVLMTLPDGQSLCATVPVNDATE 240
Cdd:PRK10676 160 AITAQSAERLGLDEGKEVLVLIKAPWVGITQDPAVAQAADNQLPGTISHIERGAEQSEVLMALPDGQTLCATVPNNEAAR 239

                        250       260
                 ....*....|....*....|....
gi 550714595 241 LD--EGAVVTAYFNADRVIIATLC 262
Cdd:PRK10676 240 LSlqQGDAVTAYFNADRVIIATLC 263
ModE_repress TIGR00637
ModE molybdate transport repressor domain; ModE is a molybdate-activated repressor of the ...
 16-113 4.15e-41

ModE molybdate transport repressor domain; ModE is a molybdate-activated repressor of the molybdate transport operon in E. coli. It consists of the domain represented by this model and two tandem copies of mop-like domain, where Mop proteins are a family of 68-residue molybdenum-pterin binding proteins of Clostridium pasteurianum. This model also represents the full length of a pair of archaeal proteins that lack Mop-like domains. PSI-BLAST analysis shows similarity to helix-turn-helix regulatory proteins. [Regulatory functions, Other]


Pssm-ID: 273188 [Multi-domain]  Cd Length: 99  Bit Score: 136.80  E-value: 4.15e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714595   16 FADPRRIALLKQIEQTGSISQGAKNAGISYKSAWDAINDMNTLSEQTLVERATGGKGGGGAVLTRYGQRLIQLYDLLAQI 95
Cdd:TIGR00637   1 FADPRRVALLKAIARMGSISQAAKDAGISYKSAWDYIRAMNNLSGEPLVERATGGKGGGGAVLTEYGQRLIQLYDLLERI 80

                          90
                  ....*....|....*....
gi 550714595   96 QQKAFDVLSDDDNL-PLDS 113
Cdd:TIGR00637  81 LEKAFSVLEDEVVVkPLKA 99
MopI COG3585
Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];
124-262 1.97e-39

Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];


Pssm-ID: 442804 [Multi-domain]  Cd Length: 141  Bit Score: 134.05  E-value: 1.97e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714595 124 QTSARNQWFGTVTGRDHSQVQEHIEILLADGTTRLKAAITAQSGQRLGLNEGQEVLVLLKAPWISITLNPEQAAEADNQL 203
Cdd:COG3585    1 MTSSRNNQFGGVVSIIAGGVVNEVVLLLLGGGTIIAAITTASSAELLGLVGGKEVAALKKASVVILATDDAMKLSARNQL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550714595 204 RGRISHIERGAEQCEVLMTLPDGQSLCATVPVNDATELD--EGAVVTAYFNADRVIIATLC 262
Cdd:COG3585   81 KGTVTRIERGAVNSEVVLDLGGGTTLTAVITNESVEELGlkEGDEVTALFKASSVILAVDA 141
ModE COG2005
DNA-binding transcriptional regulator ModE (molybdenum-dependent) [Transcription];
1-113 1.20e-37

DNA-binding transcriptional regulator ModE (molybdenum-dependent) [Transcription];


Pssm-ID: 441608 [Multi-domain]  Cd Length: 118  Bit Score: 128.40  E-value: 1.20e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714595   1 MQAEILLTLRLQQKLFADPRRIALLKQIEQTGSISQGAKNAGISYKSAWDAINDMNTLSEQTLVERATGGKGGGGAVLTR 80
Cdd:COG2005    3 MKLRLKLWLELDGGVFLGPGRIELLEAIDETGSISAAAKAMGMSYKRAWDLIDAMNNLLGEPLVERQTGGKGGGGARLTP 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 550714595  81 YGQRLIQLYDLLAQIQQKAFDVLSDDDNLPLDS 113
Cdd:COG2005   83 EGRRLLALYRRLEAEAQRALAALFEELFALLRS 115
Mop TIGR00638
molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin ...
 123-191 1.49e-20

molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin binding proteins of about 70 amino acids in Clostridium pasteurianum, as a tandemly-repeated domain C-terminal to an unrelated domain in ModE, a molybdate transport gene repressor of E. coli, and in single or tandemly paired domains in several related proteins. [Transport and binding proteins, Anions]


Pssm-ID: 273189 [Multi-domain]  Cd Length: 69  Bit Score: 82.79  E-value: 1.49e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550714595  123 LQTSARNQWFGTVTGRDHSQVQEHIEILLADGTTrLKAAITAQSGQRLGLNEGQEVLVLLKAPWISITL 191
Cdd:TIGR00638   1 LQTSARNQLKGKVVAIEDGDVNAEVDLLLGGGTK-LTAVITLESVAELGLKPGKEVYAVIKAPWVILAV 68
TOBE pfam03459
TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the ...
 199-256 2.27e-10

TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum and sulfate. Found in ABC transporters immediately after the ATPase domain.


Pssm-ID: 427310 [Multi-domain]  Cd Length: 60  Bit Score: 54.98  E-value: 2.27e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714595  199 ADNQLRGRISHIERGAEQCEVLMTLPDGQSLCATVPVNDATELD--EGAVVTAYFNADRV 256
Cdd:pfam03459   1 ARNQLPGTVTVIEPLGSEVEVRVDLGGGLTLTARITRDSAEELGlaPGDEVWALIKATKV 60
MopI COG3585
Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];
123-184 1.50e-09

Molybdopterin-binding protein MopI [Coenzyme transport and metabolism];


Pssm-ID: 442804 [Multi-domain]  Cd Length: 141  Bit Score: 55.08  E-value: 1.50e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550714595 123 LQTSARNQWFGTVTGRDHSQVQEHIEILLADGTTrLKAAITAQSGQRLGLNEGQEVLVLLKA 184
Cdd:COG3585   72 MKLSARNQLKGTVTRIERGAVNSEVVLDLGGGTT-LTAVITNESVEELGLKEGDEVTALFKA 132
TOBE pfam03459
TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the ...
 127-187 5.16e-08

TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum and sulfate. Found in ABC transporters immediately after the ATPase domain.


Pssm-ID: 427310 [Multi-domain]  Cd Length: 60  Bit Score: 48.43  E-value: 5.16e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550714595  127 ARNQWFGTVTGRDHSQVQEHIEILLADGTTrLKAAITAQSGQRLGLNEGQEVLVLLKAPWI 187
Cdd:pfam03459   1 ARNQLPGTVTVIEPLGSEVEVRVDLGGGLT-LTARITRDSAEELGLAPGDEVWALIKATKV 60
Mop TIGR00638
molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin ...
 199-260 9.69e-06

molybdenum-pterin binding domain; This model describes a multigene family of molybdenum-pterin binding proteins of about 70 amino acids in Clostridium pasteurianum, as a tandemly-repeated domain C-terminal to an unrelated domain in ModE, a molybdate transport gene repressor of E. coli, and in single or tandemly paired domains in several related proteins. [Transport and binding proteins, Anions]


Pssm-ID: 273189 [Multi-domain]  Cd Length: 69  Bit Score: 42.34  E-value: 9.69e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550714595  199 ADNQLRGRISHIERGAEQCEVLMTLPDGQSLCATVPVNDATELD--EGAVVTAYFNADRVIIAT 260
Cdd:TIGR00638   5 ARNQLKGKVVAIEDGDVNAEVDLLLGGGTKLTAVITLESVAELGlkPGKEVYAVIKAPWVILAV 68
TOBE_2 pfam08402
TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the ...
 193-258 3.33e-04

TOBE domain; The TOBE domain (Transport-associated OB) always occurs as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum and sulphate. Found in ABC transporters immediately after the ATPase domain. In this family a strong RPE motif is found at the presumed N-terminus of the domain.


Pssm-ID: 462465 [Multi-domain]  Cd Length: 73  Bit Score: 38.37  E-value: 3.33e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550714595  193 PEQ--AAEADNQLRGRISHIE-RGAEQcEVLMTLPDGQSLCATVPVNDATELDEGAVVTAYFNADRVII 258
Cdd:pfam08402   5 PEKirLAAAANGLSGTVTDVEyLGDHT-RYHVELAGGEELVVRVPNAHARPPAPGDRVGLGWDPEDAHV 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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