|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15419 |
PRK15419 |
sodium/proline symporter PutP; |
1-502 |
0e+00 |
|
sodium/proline symporter PutP;
Pssm-ID: 185317 Cd Length: 502 Bit Score: 893.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 1 MAISTPMLVTFLVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAI 80
Cdd:PRK15419 1 MAISTPMLVTFCVYIFGMILIGFIAWRSTKNFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGISESWIAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 81 GLTVGAWINWKLVAGRLRVHTEANNNALTLPDYFTGRFEDNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSY 160
Cdd:PRK15419 81 GLTLGAWINWKLVAGRLRVHTEYNNNALTLPDYFTGRFEDKSRILRIISALVILLFFTIYCASGIVAGARLFESTFGMSY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 161 ETALWAGAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFGESLEVIKQKSIENVDMLKGLNFVAIVS 240
Cdd:PRK15419 161 ETALWAGAAATILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVIISVGGFGDSLEVIKQKSIENVDMLKGLNFVAIIS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 241 LMGWGLGYFGQPHILARFMAADSHHTIVHARRISMTWMILCLAGACAVGFFGIAYFNNNPAQAGAVNQNAERVFIELAQI 320
Cdd:PRK15419 241 LMGWGLGYFGQPHILARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFNEHPAVAGAVNQNAERVFIELAQI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 321 LFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRFMVLLVALVAIALAANPENRVLGL 400
Cdd:PRK15419 321 LFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKHASQKELVWVGRVMVLVVALVAIALAANPENRVLGL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 401 VSYAWAGFGAAFGPVVLFSVLWSRMTRNGALAGMIIGAVTVIVWKQFAWLGLYEIIPGFIFGSLGIVVFSLLGKAPSASM 480
Cdd:PRK15419 401 VSYAWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIGALTVIVWKQFGWLGLYEIIPGFIFGSIGIVVFSLLGKAPSAAM 480
|
490 500
....*....|....*....|..
gi 550714797 481 QKRFAEADAHYHSAPPSKLQAE 502
Cdd:PRK15419 481 QKRFAEADAHYHSAPPSRLQEE 502
|
|
| Na_Pro_sym |
TIGR02121 |
sodium/proline symporter; This family consists of the sodium/proline symporter (proline ... |
5-492 |
0e+00 |
|
sodium/proline symporter; This family consists of the sodium/proline symporter (proline permease) from a number of Gram-negative and Gram-positive bacteria and from the archaeal genus Methanosarcina. Using the related pantothenate permease as an outgroup, candidate sequences from Bifidobacterium longum and several from archaea are found to be outside the clade defined by known proline permeases. These sequences, scoring between 570 and -40, define the range between trusted and noise cutoff scores. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273981 Cd Length: 487 Bit Score: 704.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 5 TPMLVTFLVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTV 84
Cdd:TIGR02121 1 TEILITFGVYLIIMLLIGFYAYKKTTNLSDYVLGGRSLGPFVTALSAGASDMSGWLLMGLPGALYVTGLSELWIAIGLTI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 85 GAWINWKLVAGRLRVHTEANNNALTLPDYFTGRFEDNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETAL 164
Cdd:TIGR02121 81 GAYINWKFVAPRLRVYTEAAHNSITLPDFFENRFNDKSRLLRIISALIILVFFTIYTSSGLVAGGKLFESTFGLDYKTGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 165 WAGAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFGESLEVIKQKSIENVDMLKGLNFVAIVSLMGW 244
Cdd:TIGR02121 161 LIGALIIVIYTFFGGFLAVSWTDFVQGLLMFFALVLVPIVALFNLGGFGETLSAVAAINPHLLDMFKGASVIAIISLLAW 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 245 GLGYFGQPHILARFMAADSHHTIVHARRISMTWMILCLAGACAVGFFGIAYFNNNPAQAGAvnqNAERVFIELAQILFNP 324
Cdd:TIGR02121 241 GLGYFGQPHIIVRFMAIRSHKELPKARRIGMSWMILSLLGAIAVGLTGIAYFNKNPHVELV---DRETIFIVLSQILFHP 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 325 WIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRFMVLLVALVAIALAANPENRVLGLVSYA 404
Cdd:TIGR02121 318 WIAGILLAAILAAIMSTISSQLLVSSSALTEDFYKAFFKREASQKELVMVGRLSVLVIAIIAIILAMNPNSSILNLVGYA 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 405 WAGFGAAFGPVVLFSVLWSRMTRNGALAGMIIGAVTVIVW--KQFAWLGLYEIIPGFIFGSLGIVVFSLLGKAPSASMQK 482
Cdd:TIGR02121 398 WAGFGAAFGPVVLFSLYWKRMTRNGALAGMIIGAVTVIVWisKLGGSFGLYEIVPGFIISSIVIVVVSKLTKAPPAAVQT 477
|
490
....*....|
gi 550714797 483 RFAEADAHYH 492
Cdd:TIGR02121 478 VFEKAKKLVK 487
|
|
| SLC5sbd_PutP |
cd11475 |
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ... |
8-472 |
0e+00 |
|
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271369 Cd Length: 464 Bit Score: 569.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 8 LVTFLVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTVGAW 87
Cdd:cd11475 1 LITFIVYLLLMLGIGIYSYRKTKTLEDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYASGLSAIWIAIGLILGAY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 88 INWKLVAGRLRVHTEANNnALTLPDYFTGRFEDNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETALWAG 167
Cdd:cd11475 81 LNWLFVAKRLRRYTEKND-SITLPDYLENRFRDKSKLLRILSALIILIFFTIYAAAQLVAGGKLFESLFGIDYSTGLLIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 168 AAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFGESLEVIKQKSIENVDMLKGLN----FVAIVSLMG 243
Cdd:cd11475 160 AVVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAALGGLSGLVAALAAIDPGLLSPFGGDLgaggLLAIISLLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 244 WGLGYFGQPHILARFMAADSHHTIVHARRISMTWMILCLAGACAVGFFGIAYFNNNPAQagavnqNAERVFIELAQILFN 323
Cdd:cd11475 240 WGLGYFGQPHILVRFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGRALFPDGLLG------DPETVFPVLAQELFP 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 324 PWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRFMVLLVALVAIALAANPENRVLGLVSY 403
Cdd:cd11475 314 PWLAGILLAAILAAIMSTADSQLLVCSSALTEDLYKAFLRKEASDKELVWVSRLAVLVIALIALLIALNPPSSVFSLVSF 393
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550714797 404 AWAGFGAAFGPVVLFSVLWSRMTRNGALAGMIIGAVTVIVWKQF--AWLGLYEIIPGFIFGSLGIVVFSLL 472
Cdd:cd11475 394 AWAGLGAAFGPLLLLSLYWKRTTRQGALAGMIAGAVTVVVWKLLglGIFGLYEIVPGFLASLLAIVVVSLL 464
|
|
| SSF |
pfam00474 |
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
35-437 |
1.52e-138 |
|
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.
Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 405.18 E-value: 1.52e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 35 YILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTVGAWINWKLVAGRLRvhteaNNNALTLPDYF 114
Cdd:pfam00474 1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLR-----NLGAYTMPDYL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 115 TGRFEdNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAATILYTFVGGFLAVSWTDTVQASLM 194
Cdd:pfam00474 76 RKRFG-GKRILVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLM 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 195 IFALILTPIIVIFTVGGFgeSLEVIKQKSIEN--VDMLKG------LNFVAIVSL-MGWGLGYFGQPHILARFMAADSHH 265
Cdd:pfam00474 155 LFGTIILMIIVFHEVGGY--SSAVEKYMTADPngVDLYTPdglhilRDPLTGLSLwPGLVLGTTGLPHILQRCLAAKDAK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 266 TIVHARRISMTWMILCLAGACAVGFFGIAYFNNNPAQAGAVNQNAERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQ 345
Cdd:pfam00474 233 CIRCGVLILTPMFIIVMPGMISRGLFAIALAGANPRACGTVVGCSNIAYPTLAVKLGPPGLAGIMLAVMLAAIMSTLTSQ 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 346 LLVCSSAITEDLYKAFLRKG-ASQKELVWVGRFMVLLVALVAIALAANPENR-VLGLVSYAWAGFGAAFGPVVLFSVLWS 423
Cdd:pfam00474 313 LLSSSSAFTHDLYKNIRRKAsATEKELVGRSRIIVLVVISLAILLAVQPAQMgIAFLVQLAFAGLGSAFLPVILLAIFWK 392
|
410
....*....|....
gi 550714797 424 RMTRNGALAGMIIG 437
Cdd:pfam00474 393 RVNEQGALWGMIIG 406
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
4-485 |
2.44e-127 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 379.16 E-value: 2.44e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 4 STPMLVTFLVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLT 83
Cdd:COG0591 2 STLDLIIIILYLLLLLGIGLYASRRTKSLEDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSALWYALGYA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 84 VGAWINWKLVAGRLRVHteannNALTLPDYFTGRFednSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETA 163
Cdd:COG0591 82 LGALLLALFFAPRLRRL-----GALTIPEFLEKRF---GRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 164 LWAGAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFGESLEVIKQKSIENV-DMLKGLNFVAIVSLM 242
Cdd:COG0591 154 ILIGALIVLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALGGFGELFAALPAPGLLSLfPGLGFTGWLAFLGLF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 243 -GWGLGYFGQPHILARFMAADSHHTIVHARRISMTWMILCLAGACAVGFFGIAYFNNNPAQagavnqNAERVFIELAQIL 321
Cdd:COG0591 234 lAIGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALFPDLPLA------DPDLALPLLILEL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 322 FNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRFMVLLVALVAIALAANPENRVLGLV 401
Cdd:COG0591 308 LPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKPKASDKQLLRVSRLAVLVVGLLALLLALLFPSSILDLV 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 402 SYAWAGFGAAFGPVVLFSVLWSRMTRNGALAGMIIGAVTVIVWKQF-----AWLGLYEIIPGFIFGSLGIVVFSLLGKAP 476
Cdd:COG0591 388 LLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLLggplgPFGWLYPILPGLLVSLLVFVVVSLLTKPP 467
|
....*....
gi 550714797 477 SASMQKRFA 485
Cdd:COG0591 468 SEEVLEEFD 476
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
38-437 |
1.19e-111 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 336.58 E-value: 1.19e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 38 GGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGIseswiAIGLTVGAWINWKLVAGRLRVHTEANNNALTLPDYFTGR 117
Cdd:TIGR00813 1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGF-----AIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 118 FedNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAATILYTFVGGFLAVSWTDTVQASLMIFA 197
Cdd:TIGR00813 76 F--GKRILRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 198 LILTPIIVIFTVGGFGESLEVIKQ--KSIENVDMLKGLNFVAIVSLMGWGLGYFGQPH----------ILARFMAADSHH 265
Cdd:TIGR00813 154 TFILPVFAFSEVGGLGTFVEKASQaaPTNPSPDDLYDFFRDPSTSDLPWGAGVFGLPHvalwywtnqvIVQRCLAAKSAK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 266 TIVHARRISMTWMILCLAGACAVGFFGIAYFNN-NPAQAGAVNQNAERVFIELAQILFNPWIAGILLSAILAAVMSTLSC 344
Cdd:TIGR00813 234 HAKKGCLISGVLKLLPMFGAVLPGLIARALYTDiDPALAGAVNQNSDQAYPLLVQELMPPGLAGLFLAAILAAVMSTLSS 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 345 QLLVCSSAITEDLYKAFLRKGAS-QKELVWVGRFMVLLVALVAIALAANPENRVLGLVSYAWAGFGAAFGPVVLFSVLWS 423
Cdd:TIGR00813 314 QLNSASTVFTMDLYKKIIRPNASgEKKIVMRGRIAVLVAAVIAGFVAAAQGGQVLQYVQEAFGGLGAPFLPVFLLGIFWK 393
|
410
....*....|....
gi 550714797 424 RMTRNGALAGMIIG 437
Cdd:TIGR00813 394 RMNAKGALAGMIAG 407
|
|
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
8-470 |
1.14e-79 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 255.56 E-value: 1.14e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 8 LVTFLVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTVGAW 87
Cdd:cd10322 3 LIIVVVYLALLLGIGLYASKKVKSSEDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAALGAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 88 INWKLVAGRLRvhteaNNNALTLPDYFTGRFedNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETALWAG 167
Cdd:cd10322 83 LLALFLAPRLR-----RLGKTTIPETILERY--YSKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVIIA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 168 AAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVG--GFGESLEVIKQKSIENVDMLKGLNFVAIVSLMGWG 245
Cdd:cd10322 156 AVIVILYTVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGggGFSALAAALPALLLALGPGGGLGWSTILSLILLTG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 246 LGYFGQPHILARFMAADSHHTivhARRISMTWMILCLAGACAVGFFGIAYFNNNPAQagavnQNAERVFIELAQILFNPW 325
Cdd:cd10322 236 LGVLALPQVFQRILAAKDEKT---ARRAFLLAGLLLLLIGFLVALIGLAARALFPDL-----ENPDLALPTLINSLLPPG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 326 IAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRFMVLLVALVAIALAANPENrVLGLVSYAW 405
Cdd:cd10322 308 LAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKASDKKLLRVSRIAVVVVGVLALLLALLPPS-ILLLLSLAA 386
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550714797 406 AGFGAAFGPVVLFSVLWSRMTRNGALAGMIIGAVTVIVWKQF---AWLGLYEIIPGFIFGSLGIVVFS 470
Cdd:cd10322 387 GLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLplaSPLGIDPIIPALLVSLIVFVVVS 454
|
|
| PanF |
COG4145 |
Na+/panthothenate symporter [Coenzyme transport and metabolism]; |
4-484 |
2.23e-66 |
|
Na+/panthothenate symporter [Coenzyme transport and metabolism];
Pssm-ID: 443316 Cd Length: 484 Bit Score: 221.64 E-value: 2.23e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 4 STPMLVTFLVYIFGMILIGFLAWR---STKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAI 80
Cdd:COG4145 3 NLAILIPLLIYLLLVLGIGIYASRkrsKGSFLEEYFLGSRSMGGFVLAMTLAATYTSASSFIGGPGAAYKYGLGWVLLAM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 81 GLTVGAWINWKLVAGRLRVHTEaNNNALTLPDYFTGRFedNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSY 160
Cdd:COG4145 83 IQVPTAFLTLGVLGKKFAILGR-KYNAVTLADWLRARY--QSKALVLLAALLLLLFFIAFMVAQFVGGARLLETVTGISY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 161 ETALWAGAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFGESLEVIKQksiENVDMLKGLN------ 234
Cdd:COG4145 160 TTGLLIFGVTVVLYTTIGGFRAVVLTDAIQGIIMLVGTVLLLIGVISAGGGIENIMSTLAA---IDPNLVSPTGpdgflp 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 235 --FVAIVSLMgWGLGYFGQPHILARFMAADSHHTIVHARRISMTWMILCLAGACAVGFFGIAYFNNNPAqagavnqnAER 312
Cdd:COG4145 237 rpFVISFWIL-VGFGVIGLPHTAVRCMAYKDSKSLHRAMIIGTIVVGLLMFGMHLIGVLGRAVLPDLTV--------PDQ 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 313 VFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQ--KELVWVGRFMVLLVALVAIALA 390
Cdd:COG4145 308 VIPTLMVKVLPPFLAGIFLAGPLAAIMSTVDSLLLQASSTIVKDLYLNYINPKASEneKKLKRLSKLVTLVLGLIVFLLA 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 391 ANPENRVLGLVSYAWAGFGAAFGPVVLFSVLWSRMTRNGALAGMIIGAVTVIV--WKQFAWLGLYEIIPGFIFGSLGIVV 468
Cdd:COG4145 388 LNPPDLIIWLNLFAFGGLEAAFFWPLVLGLYWKRANATGAIASMLVGVASYFLlyYGNPKIFGFHAIVPSLLISLIAFLI 467
|
490
....*....|....*.
gi 550714797 469 FSLLGKAPSASMQKRF 484
Cdd:COG4145 468 GSLLGKPPDEERLELF 483
|
|
| SLC5sbd_PanF |
cd10327 |
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ... |
7-477 |
7.06e-57 |
|
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212037 Cd Length: 472 Bit Score: 196.27 E-value: 7.06e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 7 MLVTFLVYIFGMILIGFLAWRSTKN-----FDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIG 81
Cdd:cd10327 1 VLLPIIIYLVILLGIGFYARRSKKRrsgdfLEEYFIGGRSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGLGWVLLAMI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 82 LTVGAWI-------NWKLVAGRLrvhteannNALTLPDYFTGRFedNSRILRIISAVVILLFFTIYCASGIVAGARLFES 154
Cdd:cd10327 81 QVPTGFLtlgvlgkKFAIIARKI--------NAVTIIDYLRARY--NSKALVVLSSLALIVFFIAAMVAQFIGGARLLEA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 155 TFGMSYETALWAGAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFGESLEVIKQKSiENVDMLKGLN 234
Cdd:cd10327 151 VTGLSYVTGLLIFGLTVILYTTIGGFRAVALTDAIQGIVMIIGTVLLLVGVLAAGGGMEAIMATLAEID-PNLLTPFGPG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 235 FVAIVSLMG-W---GLGYFGQPHILARFMAA-DS---HHTIVHARRISMTWMIlclaGACAVGFFGIAYFNNNPAqagav 306
Cdd:cd10327 230 FLSPPYILSfWvlvGFGVIGLPQTAVRCMGYkDSksmHRAMIIGTVVVGFLML----GMHLAGVLGRAVLPDLEV----- 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 307 nqnAERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKG--ASQKELVWVGRFMVLLVAL 384
Cdd:cd10327 301 ---PDKVIPTLALKVLPPWLAGLFLAGPLAAIMSTVDSQLILASSAIVKDLYLNYKNKEkkTSEKKVKRISLIITIILGL 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 385 VAIALAANPENRVLGLVSYAWAGFGAAFGPVVLFSVLWSRMTRNGALAGMIIGAVTVIVWKQF--AWLGLYEIIPGFIFG 462
Cdd:cd10327 378 LVFLLAINPPDLIVWLNLFAFGGLEAAFFWPLVLGLYWKRANATGALASMVVGLVSYILITYLkiKILGLHPIVPSLLLS 457
|
490
....*....|....*
gi 550714797 463 SLGIVVFSLLGKAPS 477
Cdd:cd10327 458 LIAFIIVSLATKKPD 472
|
|
| ActP |
COG4147 |
Na+(or H+)/acetate symporter ActP [Energy production and conversion]; |
1-492 |
3.25e-54 |
|
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
Pssm-ID: 443318 Cd Length: 526 Bit Score: 190.37 E-value: 3.25e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 1 MAISTPMLVTFLVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAI 80
Cdd:COG4147 8 LGMNLLAIGIFLVFVTFTLYITIWAARRTKSTSDFYVAGRGVTGVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLIYSI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 81 GLTVGAWINWKLVAGRLRvhteaNNNALTLPDYFTGRFedNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSY 160
Cdd:COG4147 88 GWLVGYVLLLLLLAEYLR-----NFGKFTVPDFLGDRF--YSRPARLVAAISTLVVSFFYLIAQMVGAGVLISLLLGVDY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 161 ETALWAGAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGG-FGESLEVIKQKSIENVDMLK-------G 232
Cdd:COG4147 161 EVAVVIVGVLMIVYVVLGGMKGTTWVQIIKAVLLIFAYTVPAVLVLAQFGFnPLPLLAKAAEVHDLGAAYLEpgglvksP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 233 LNFVAI-VSLMgwgLGYFGQPHILARFMAADShhtiVHARRISMTWMI----LCLAGACAVGFFGIAYFNNNPA-----Q 302
Cdd:COG4147 241 LDFISLgLALM---LGTAGLPHILMRFFTVPD----AKEARKSVGWALgfigLFYLTAPALGFGARALVGPLPEwfdtgL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 303 AGAVNQNAERVFIELAQILFNP-WIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRFMVLL 381
Cdd:COG4147 314 IGAADGGGNMAVLALAEIAGGGnWLLGLVAAGAFATILAVVAGLLLAIASAISHDLYANVIKGKATEKEELRVARIAAVV 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 382 VALVAIALAANPENR-VLGLVSYAWAGFGAAFGPVVLFSVLWSRMTRNGALAGMIIG---AVTVIVW--------KQFAW 449
Cdd:COG4147 394 IGVVAILLGINAPPQnVAFLVALAFALAASANFPVLLLSIFWKRFNTRGAVAGMLVGlisALVLIVLspfvwvlgVDAAL 473
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 550714797 450 LGLyeIIPGFI---FGSLGIVVFSLLGKAPSASMQKRFAEADAHYH 492
Cdd:COG4147 474 FPL--ENPGLVsmpLGFLVAIVVSLLTPEPPAEDQELVEEQEVRSP 517
|
|
| SLC5sbd_u4 |
cd11480 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
8-472 |
1.06e-47 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271374 Cd Length: 488 Bit Score: 171.92 E-value: 1.06e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 8 LVTFLVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTVGAW 87
Cdd:cd11480 1 IGLFFVFVTITLYITIWAARRTRSTSDFYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLAYAIGWTGGYV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 88 INWKLVAGRLRvhteaNNNALTLPDYFTGRFedNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETALWAG 167
Cdd:cd11480 81 LLLLLVAEPLR-----NFGKYTVPDFLGARL--GSRPVRLVAAVSTLVISFFYLVAQMVGAGLLLSLLLGIPYEVGVVVV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 168 AAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFGESLEVIKQKSIENVDMLKGLNFVA---------- 237
Cdd:cd11480 154 GALMIVYVVLGGMRATTWVQIIQYVLLLGAFLVPAILVLARFGGNPLGAGPGLLGLAAAAASGAGEAYLApgllltdpld 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 238 ----IVSLMgwgLGYFGQPHILARFMAADShhtiVHARRISMTWMILCLA----GACAVGFFGIAYFNNNPAQAGAVNQ- 308
Cdd:cd11480 234 vislTLALM---LGTAGLPHVLMRFYTVPD----ARAARKSVVWALGFIGlfylLAPALGFGARALVGPDVIGAPIAGEl 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 309 --NAERVFIELAQILFNPWIAGILLSAI-LAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRFMVLLVALV 385
Cdd:cd11480 307 dgGGDMAVLLLPEIAGLGDLLLALVAAGaFAAILATVAGLLLAAASALAHDLYAGVIRPGASERREVRVARIAAVVVGVI 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 386 AIALAANPENR-VLGLVSYAWAGFGAAFGPVVLFSVLWSRMTRNGALAGMIIGAVTVIV-----------WKQFAWLGLY 453
Cdd:cd11480 387 AILLALLFPPQnVAFLVALAFAIAASAFFPVLVLGIFWRRFTTRGAIAGMLVGLLVSLVlivlspavsgaPPGHDFAGFP 466
|
490 500
....*....|....*....|..
gi 550714797 454 EIIPGFI---FGSLGIVVFSLL 472
Cdd:cd11480 467 LTNPGLVsvpLGFLVAIVVSLL 488
|
|
| panF |
TIGR02119 |
sodium/pantothenate symporter; Pantothenate (vitamin B5) is a precursor of coenzyme A and is ... |
8-476 |
3.36e-46 |
|
sodium/pantothenate symporter; Pantothenate (vitamin B5) is a precursor of coenzyme A and is made from aspartate and 2-oxoisovalerate in most bacteria with completed genome sequences. However, some pathogens must import pantothenate. This model describes PanF, a sodium/pantothenate symporter, from a larger family of Sodium/substrate symporters (pfam00474). Several species that have this transporter appear to lack all enzymes of pantothenate biosynthesis, namely Haemophilus influenzae, Pasteurella multocida, Fusobacterium nucleatum, and Borrelia burgdorferi. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A, Transport and binding proteins, Other]
Pssm-ID: 131174 Cd Length: 471 Bit Score: 167.60 E-value: 3.36e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 8 LVTFLVYIFGMILIGFLAWRSTKNF-DDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTVGA 86
Cdd:TIGR02119 7 LIIYLVTVFLIAIYASKRVQSTDSFlNEYFLGGRSMGGFVLAMTLVATYGSASSFIGGPGIAYNYGLGWVLLAMIQVPTG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 87 WINWKLVAGRLRVHTEaNNNALTLPDYFTGRFedNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETALWA 166
Cdd:TIGR02119 87 YFVLGVLGKKFAIISR-KYNAITINDVLKARY--NNKFLVWLSSISLLVFFFSAMVAQFIGGARLIESLTGLSYLTALFI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 167 GAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFGESLEVIKQKSIENVDMLKGLNFVAIVSLMGW-- 244
Cdd:TIGR02119 164 FSSSVLIYTTFGGFRAVALTDAIQGIVMFTGTTILLIAVIKAGGGVEKIMEKLKDIDPNLITPFGGDGGLTKPFVASFwi 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 245 --GLGYFGQPHILARFMAADSHHTIVHARRISMTWMILCLAGACAVGFFGIAYFNNNpaqagavnQNAERVFIELAQILF 322
Cdd:TIGR02119 244 lvGIGVIGLPQTAVRCMSYKDSKAMHRAMIIGTIVVGIIMLGMHLAGVLGRAVIPDL--------TVPDKVIPLLAIKVL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 323 NPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRFMVLLVALVAIALAANPENRVLGLVS 402
Cdd:TIGR02119 316 PPILAGIFLAAPMAAIMSTVNSLLLQSSSTIIKDLYLNYIPKEAKESKIKKISMCITLIIGLLVIIAAIKPPDLIIWLNL 395
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550714797 403 YAWAGFGAAFGPVVLFSVLWSRMTRNGALAGMIIGAVTVIVWKQF--AWLGLYEIIPGFIFGSLGIVVFSLLGKAP 476
Cdd:TIGR02119 396 FAFGGLEAAFIWPIVLGLYWKRANATGALASMIVGVGSYITLESFkpKIFGLHNIVPSLVFALIAFIIGSLFGKKS 471
|
|
| SLC5sbd_CHT |
cd11474 |
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
12-477 |
5.01e-41 |
|
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 153.06 E-value: 5.01e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 12 LVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGIsesWIAIGLTVGAWINWK 91
Cdd:cd11474 5 ILYYLLILGIGLWASRRVKSSEDFLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGL---GGVAQDPFGYALCLI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 92 LV----AGRLRVHteannNALTLPDYFTGRFednSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETALWAG 167
Cdd:cd11474 82 LGglffAKPMRRM-----GLLTLGDFFRQRY---GRRVEVLLSIPAVLSYLGWVAAQLVALGLVLSVILGLPVETGILIS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 168 AAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFG--ESLEVIKQKSIENVDMLKG-LNFVAIVSLMGW 244
Cdd:cd11474 154 AAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGGVDiaSAAAAGKLRFFPWLGTKSDwLIWIDAWLTLGL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 245 G----LGYFgqphilARFMAADSHHTivhARRISMTWMILCLAGACAVGFFGIAYFNNNPAQAGA-VNQNAERVFIELAQ 319
Cdd:cd11474 234 GsipqQDVF------QRVLSAKSEKT---AQRLSLLAGVGYLLFAIPPLLIGLAAASIDPSLTQYgLEEDAQLILPLLLQ 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 320 ILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRFMVLLVALVAIALAANPENrVLG 399
Cdd:cd11474 305 YLTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYKPPFRPKASDRELLWVMRISVVVFGAIATLMALTVES-IYG 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 400 LVSYAWA-GFGAAFgPVVLFSVLWSRMTRNGALAGMIIGAVTVIVWKqFAWLGLYEIIP----GFIFGSLGIVVFSLLGK 474
Cdd:cd11474 384 LVELASDlVLVGLF-VPLLAGLYWKRANTYGALAAIIVGLVLRLLGG-ELLLGLPADIPpqlqGFPFSTLAMVIGSLLPL 461
|
...
gi 550714797 475 APS 477
Cdd:cd11474 462 AVS 464
|
|
| YidK |
COG4146 |
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ... |
1-443 |
8.95e-37 |
|
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];
Pssm-ID: 443317 [Multi-domain] Cd Length: 444 Bit Score: 141.05 E-value: 8.95e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 1 MAISTPMLVTFLVYIFGMILIGFLAWRSTK--NFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGIS---- 74
Cdd:COG4146 1 MGLSTLDYIVFLLYFLLVAGIGYWVSRKKKekTSEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYATGLAvaay 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 75 ESWIAIGLTVGAWInwkLVAGRLRvhteanNNALTLPDYFTGRFEDNSRilRIISAVVILLFFTIYCASGIVAGARLFES 154
Cdd:COG4146 81 EWMAAIALIILALF---FLPFYLK------SGIYTMPEFLEKRYDRRTR--TILSILFLVSYVFVNLPSVLYAGALALNT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 155 TFGMSYETALWAGAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVG--GFGESLEVIKQKSIENVDMLKG 232
Cdd:COG4146 150 IFGVPLWISVIGLGIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLDAVGdgSVLAGWSALLKVPPEKFNMIGP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 233 LN-----FVAIVS-LMGWGLGYFG--QpHILARFMAADShhtIVHARRismtwmilclaGACAVGFF-----------GI 293
Cdd:COG4146 230 ADdpdlpWLGIFTgMPILNLFYWGtnQ-YIVQRALGAKN---LKEAQK-----------GVLFAGFLkllipfivvlpGI 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 294 AYFNNNPAQAgavnQNAERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVW 373
Cdd:COG4146 295 IAFVLFPDGL----DNPDQAYPTLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKYFNPNASEKQLVK 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 374 VGRFMVLlvalvaialaanpenrVLGLVSYAWAGFGAAFGP------------------VVLFSVLWSRMTRNGALAGMI 435
Cdd:COG4146 371 VGRIATV----------------VLAVIAILIAPLIGNADGlfqyiqevtgffsppilaVFLLGLFWKRVTAKAAKVALI 434
|
....*...
gi 550714797 436 IGAVTVIV 443
Cdd:COG4146 435 AGIVLSIL 442
|
|
| SLC5sbd_u1 |
cd11477 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
12-484 |
4.78e-29 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271371 Cd Length: 493 Bit Score: 119.61 E-value: 4.78e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 12 LVYIFGMILIGF-LAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTVGAWINW 90
Cdd:cd11477 7 ALYFLLMLGIGLwFSKRASKSTSDFFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIWWLWAVAGLIGA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 91 KLVAG---RLRVHTEANNNALtlpdYFTGRFednSRILRIISAVVILLFFTIYCASGIVAGARLF-ESTFGMSYETALWA 166
Cdd:cd11477 87 FVFARrwrRLRVLTDGEFPEE----RYGGRY---GAPLRQFYAVYFALLSNVDILAWVFLAAIKVsAVFGPWDPWLTILI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 167 GAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFGESLEVIKQKSIENVDMLKGLN-----FVAIVSL 241
Cdd:cd11477 160 LGLITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLALNAVGGPGGLFAQLPEGHLDLFGSGLGASgfyitFFFILFF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 242 MGWGLGYFGQP-HILARFMAADSHH--------TIVHARRISMTWMIlclagacaVGFFGIAYFNNnpaqAGAVNQNAER 312
Cdd:cd11477 240 GWYPLSYSGGGwYLAQRYLSAKSEKaakaaawlFAALYLVRPWPWML--------PALAALVLYPD----LDDPEADFEL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 313 VFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRFMVLLVALVAIALAAN 392
Cdd:cd11477 308 AYPMMIKEYLPAGLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRFIKPNASEKHLLKVGRLATVLFGLLSIVVALA 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 393 pENRVLGLVSYAWAgFGAAFGPVVLFSVLWSRMTR----NGALAGMIIGAVTVIVWKQFAW--LGLYEIIPGFIFGSLGI 466
Cdd:cd11477 388 -SDSIGGAFWIVLA-LGAGLGGPLILPWLWWRFNAwteiWAMIASIIVGLVVSVLLKVFGLpeDFLFSFLVPVLLSLVVW 465
|
490
....*....|....*...
gi 550714797 467 VVFSLLGKAPSASMQKRF 484
Cdd:cd11477 466 LAVTLLTPPTDEETLVAF 483
|
|
| SLC5sbd_SGLT1-like |
cd10329 |
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ... |
8-483 |
4.56e-28 |
|
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271363 Cd Length: 538 Bit Score: 117.29 E-value: 4.56e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 8 LVTFLVYIFGMILIGFLAWRSTKN-FDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISES---WIA-IGL 82
Cdd:cd10329 1 IVIIAVYFVAVIAIGLWSSRKKRStVSGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGSGAASGIAVGnyeWNAaFVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 83 TVGAWInwklvagRLRVHTEANNnaLTLPDYFTGRFedNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYET 162
Cdd:cd10329 81 LLLGWV-------FLPFYIRSGV--STMPEFLEKRF--GGRSRVYLSVLSLILYVFTKISVDLYAGALVIKQLLGWDLYL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 163 ALWAGAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFGESL-EVIKQKSIENV------DMLKGLNF 235
Cdd:cd10329 150 SIIVLLVITAIYTIAGGLKAVIYTDTLQAVILIIGSAILMFLAFNEVGGGWSAYmAAIPSGTAFHLfrppddPDLPWPGL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 236 VAIVSLMGWGLGYFGQpHILARFMAADShhtIVHARRIS--------MTWMILCLAGACAVGFFGIAYFNNNPAQAGAVN 307
Cdd:cd10329 230 LLGYPILGIWYWCTDQ-VIVQRVLAAKN---LKHARRGAlfagylklLPLFLMVLPGMIARALFPDLVACVVPCGNGVGC 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 308 QNAerVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFlRKGASQKELVWVGRFMVLLVALVAI 387
Cdd:cd10329 306 SDI--AYPTLVTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYKRL-RPEASEKELVRVGRIATLVVVVISI 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 388 ALAANPENRVLGLVSYAWAGFGAAFGPVV---LFSVLWSRMTRNGALAGMIIG---AVTVIVWKQF--AWLGLYEIIPG- 458
Cdd:cd10329 383 LWAPIIQAQGGSLFNYIQSVLSYLAPPIAavfLLGIFWKRTNEQGAFWGLIAGlvlGLVRLILEFAygEPDTRPAIIGGi 462
|
490 500 510
....*....|....*....|....*....|....
gi 550714797 459 ---------FIFGSLGIVVFSLLGKAPSASMQKR 483
Cdd:cd10329 463 hflyfafllFVVSVIVTVIVSLLTPPPPAEKLAG 496
|
|
| SLC5sbd_u3 |
cd11479 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
11-476 |
7.55e-28 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271373 Cd Length: 454 Bit Score: 115.78 E-value: 7.55e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 11 FLVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTVGAWINW 90
Cdd:cd11479 6 IALYFAAMIAIGWWGMRRAKTSEDYLVAGRRLGPGLYLGTMAAVVLGGASTIGGVGLGYQYGISGMWLVVAIGLGILALS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 91 KLVAGRLrvhteANNNALTLPDYFTGRFednSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAA 170
Cdd:cd11479 86 LLLAKRI-----ARLKVYTVSEVLELRY---GPSARVISALVMLAYTLMVAVTSTIAIGTVFSVLFGLPRTLSILVGGGI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 171 TILYTFVGGFLAVSWTDTVQASLM---IFALILtpIIVIFTVGGFGESLEVIKQKSIEnvdmLKGLNFVAIVS-LMGWGL 246
Cdd:cd11479 158 VVLYSVLGGMWSITLTDIIQFVIKtigIFLLLL--PLALSKAGGLSGLQEKLPASYFD----LTSIGWDTIVTyFLLYFF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 247 GYFGQPHILARFMAADSHHTivhARRISMTWMILCLAGACAVGFFGIAYFNNNPAQAgavnqNAERVFIELAQILFNPWI 326
Cdd:cd11479 232 GILIGQDIWQRVFTARSEKV---ARWGGVAAGLYCVLYGVAGALIGMAAAVLLPDLA-----NPQNAFATMAQEVLPVGL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 327 AGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRFMVLLVALVAIALAANPENRVLGL-VSYAW 405
Cdd:cd11479 304 RGLVLAAALAAMMSTASGALLASSTVLTNDVLPRLRRKNESERSEVRLSRLFTLLLGVVVIVIAVLVNDVVAALtIAYAI 383
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550714797 406 AgFGAAFGPVVLfSVLWSRMTRNGALAGMIIGAVTVIVwkQFAWLGL---YEIIPGFIFGSLGIVVFSLLGKAP 476
Cdd:cd11479 384 L-VGGLLVPILG-GLFWKRATGAGALASMVAGSVVVLA--GMAVDGLlanTPIYYGLAVSLVAFVAVSLLTRPT 453
|
|
| SLC5sbd_DUR3 |
cd11476 |
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ... |
7-444 |
2.49e-25 |
|
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271370 Cd Length: 493 Bit Score: 108.83 E-value: 2.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 7 MLVTFLVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISES-WIAIGLTVG 85
Cdd:cd11476 7 LGALFALLMVFITRLLKRYRGKNQSSEEFMTAGRSVGTGLTAAAIVSSWTWAATLLQSATVAYQYGVSGPfWYASGATLQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 86 AWInWKLVAGRLRVHTeanNNALTLPDYFTGRFEDNSRILRIISAVVILLfftIYCASGIVAGARLFESTFGMSYETALW 165
Cdd:cd11476 87 ILL-FAPLAIRIKRLA---PNAHTLLEIVRARYGTAAHLVFLVFALFTNV---IVLAMLLLGGSAVVNALTGMPIVAASF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 166 AGAAATILYTFVGGFLAVSWTDTVQaSLMIFALILTPIIVIFT---VGGFGESLEVIKQKSIEN---------VDML--K 231
Cdd:cd11476 160 LIPLGVLLYTLFGGLRATFLTDYIH-TVIILIILLVFAFAVYTssdIGSPSKVYDLLQEAAPDLpvegnqgsyLTFKskA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 232 GLNFVAIVSLMGWGLGyFGQPHILARFMAADSHHTIVHARRISMTWM--ILCLAGACAVGFFGIAyfnNNPAQAGAvnqN 309
Cdd:cd11476 239 GLIFGIINIVGNFGTV-FLDQGYWQRAIAARPSAAVKGYFLGGLAWFaiPFLLATTLGLAALALG---LNPTFEEV---S 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 310 AERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRFMVLLVALVAIAL 389
Cdd:cd11476 312 AGLVLPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYRTYINPNATGKQLLRVSRIAVIGFGLFMGGL 391
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550714797 390 AAnpeNRVLGLVSYAWAGF--GAAFGPVV---LFSVLWSRMTRNGALAGMIIGAVT-VIVW 444
Cdd:cd11476 392 AV---GLNYIGISLGWLLLfmGILIGSAVfpvALGLYWRRQTGTAAVVSPIAGLVAgLAVW 449
|
|
| SLC5sbd_NIS-like_u3 |
cd11495 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
8-472 |
9.53e-24 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271386 [Multi-domain] Cd Length: 473 Bit Score: 103.77 E-value: 9.53e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 8 LVTFLVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTVGAW 87
Cdd:cd11495 6 YLVLVIYLLAMLGIGLYFSKKQKSTDDYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATDWNYFVGSLSIIIAAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 88 INWKLVAGRLRvhteaNNNALTLPDYFTGRFednSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETALWAG 167
Cdd:cd11495 86 LAAYFFVPFFR-----RLNVTSAYEYLEKRF---GPWARVYGSLLFILFQLGRMGIVLYLPALALSAVTGINPYIIIILM 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 168 AAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTV-GGFGESLEVikqkSIENVDMLKGLNFVAIVSLMGWGL 246
Cdd:cd11495 158 GVLCIIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFSIpGGFGEVFDI----AIANGKFSLGDFSFSLTESTIWVI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 247 ----------GYFGQPHILARFMAADShhtIVHARRisMTWMILCLAGACAVGFFGI-----AYFNNNPAQAGAVNQNaE 311
Cdd:cd11495 234 figgifnnlqSYTSDQDVVQRYLTTKS---IKEAKK--SLWTNALLALPVALLFFGIgtalyVFYQQHPELLPAGING-D 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 312 RVFielaqilfnPW---------IAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKEL-------VWVG 375
Cdd:cd11495 308 AVF---------PYfivtqlpvgVAGLIIAAIFAAAMSTISSSLNSVATCITTDFYKRLSPDPSDKQYLkvarlitLLVG 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 376 RFMVLLVALVAIALAANPENRVLGLVSYawagFGAAFGPVVLFSVLWSRMTRNGALAGMIIGAVtVIVWKQFAWLGLYEI 455
Cdd:cd11495 379 LLGTLVALYLANAGVKSLLDAFNTLTGL----FGGGLAGLFLLGIFTKRANAKGALVGIIVSII-VIFWISLLYTPIHFF 453
|
490
....*....|....*..
gi 550714797 456 IPGFIfGSLGIVVFSLL 472
Cdd:cd11495 454 LYSVI-GTLVCFVVGYV 469
|
|
| PRK12488 |
PRK12488 |
cation/acetate symporter; |
6-452 |
3.35e-22 |
|
cation/acetate symporter;
Pssm-ID: 237114 [Multi-domain] Cd Length: 549 Bit Score: 99.87 E-value: 3.35e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 6 PMLVTFLVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTVG 85
Cdd:PRK12488 33 TAIGMFMVFVLFTLGITRWAARRTRSASDFYTAGGGLTGMQNGLAIAGDMISAASFLGISAMMFMNGYDGLLYALGVLAG 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 86 AWINWKLVAGRLRvhteaNNNALTLPDYFTGRFEDNSriLRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETALW 165
Cdd:PRK12488 113 WPIILFLIAERLR-----NLGKYTFADVVSYRLAQGP--VRLTAAFGTLTVVLMYLVAQMVGAGKLIELLFGISYLYAVV 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 166 AGAAATILYTFVGGFLAVSWTDTVQASLMIFAlilTPIIVIFTVGGFGESLEVIKQKSIENVDMLKGL--------NFVA 237
Cdd:PRK12488 186 IVGALMVLYVTFGGMLATTWVQIIKAVLLLSG---TSFMAFMVLKHFGFSTEAMFASAVAVHAKGQAIlapggllsNPID 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 238 IVSL-MGWGLGYFGQPHILARFM----AADSHHTIVHARRISMTWMILCLagacAVGFFGIAYFNNNPA---QAGAVNQN 309
Cdd:PRK12488 263 AISLgLGMMFGTAGLPHILMRFFtvsdAREARKSVLYATGFIGYFYLLII----VVGFGAIVMVGTEPSyrdAGGKIIGG 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 310 AERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKG-ASQKELVWVGRFMVLLVALVAIA 388
Cdd:PRK12488 339 GNMVAVHLAQAVGGNLFLGFISAVAFATILAVVAGLALSGASAVSHDLYACVIRKGqASEAQEMRVSKIATLGIGLLAVV 418
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550714797 389 LAANPENR-VLGLVSYAWAGFGAAFGPVVLFSVLWSRMTRNGALAGMIIG---AVTVIVWKQFAWLGL 452
Cdd:PRK12488 419 LGLMFESQnIAFLSGLVLAIAASVNFPVLFLSMFWKGLTTRGAVAGSYAGlvsAVVLVVLGPAVWVNV 486
|
|
| SLC5sbd_NIS-like_u2 |
cd11494 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
12-450 |
6.00e-21 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271385 [Multi-domain] Cd Length: 473 Bit Score: 95.36 E-value: 6.00e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 12 LVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISesWIAIGLTVGAWInwk 91
Cdd:cd11494 7 VGYLLGILVYGVYKGRGQKNQEDYFLGGRSMPWWPIGLSIMATQASAITFLSAPGQAYSDGMR--FVQYYFGLPLAM--- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 92 LVAGRLRVHTEANNNALTLPDYFTGRFEDNSRILriiSAVVILLFFTIYCASGIVAGARLFESTFGMS-YETALWAGAAa 170
Cdd:cd11494 82 IFLCITFVPVFYKLKVYTAYEYLERRFGLKTRLL---TSILFLISRGLATGVTIYAPAIILSTILGWSlWLTILLIGGI- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 171 TILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVI--FTVGGFGESLEVIKQKSIENVD-------------MLKGLNF 235
Cdd:cd11494 158 TIIYTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLklLPVGFVDALLVAGKSGRLNALDfsfdlsdtytfwsGLIGGFF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 236 VAivslmgwgLGYFG--QPHIlARFMAADSHHTIVHARRISMTWMILCLAGACAVGFFGIAYFNNNPA-----QAGAVNQ 308
Cdd:cd11494 238 LY--------LSYFGtdQSQV-QRYLTAKSIKEARKSLLLNGFLKFPMQFFILLIGVLVFVFYQFNPFpvsfnPAEDETK 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 309 NAERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRFMVLlvalvaia 388
Cdd:cd11494 309 DTNYIFLRFVLNYLPPGVIGLLIAAIFAAAMSSIDSALNSLATVTVIDIYRRFFKKDASDEHYLKVSRLLTV-------- 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 389 laanpenrVLGLVSYAWAGFGAAFGPVV------------------LFSVLWSRMTRNGALAGMIIGAVTVIVWKQFAWL 450
Cdd:cd11494 381 --------FWGLLAIVFALFAGLAGSLIeavnklgslfygpilgvfLLAFFTKKANGKGVFAGAILGVIVVIVLWLFPDV 452
|
|
| SLC5sbd_NIS-like |
cd10326 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
8-456 |
2.24e-20 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271361 [Multi-domain] Cd Length: 472 Bit Score: 93.78 E-value: 2.24e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 8 LVTFLVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTVGAw 87
Cdd:cd10326 2 WAVVVVYFLILLAISYYTSRRNADNDDFFLGNRQSPWYLVAFSMIGTSLSGVTFVSVPGEVGGSGFTYLQMVLGFLLGY- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 88 inwkLVAGRLRVHTEANNNALTLPDYFTGRFEDNSR--------ILRIISAVVILLfftiycASGIVAGARLFEStFGMS 159
Cdd:cd10326 81 ----LIIAFVLLPLYYRLNLTSIYEYLEDRFGVSSRktgavfflLSRILGAGIRLY------LVALVLQQFLFDS-LGIP 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 160 YETALWAGAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVG-GFGESLEVIKQKSIENV----DMLKGLN 234
Cdd:cd10326 150 FWLTVLITGLLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNSLGlGFGEAISAAGESGYSRIfnfdDDNSRRT 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 235 F-VAIVSLMGWGLGYFG-QPHILARFMAADShhtIVHARR-ISMTWMILCLAGAC--AVGFFGIAYFNNNPAQAGAVNQN 309
Cdd:cd10326 230 FwKQFLGGIFITIAMTGlDQDMMQRNLSCKN---LKDAQKnMLTFGVILVPVNLLflLLGVLLYTYAQKNGIALPAKDSD 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 310 aeRVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKE--LVWVGRFMVLLVALVAI 387
Cdd:cd10326 307 --QLFPYFALNGLPPGVSGLFVAGIIAAAMSSADSALTALTTSFCVDILNRFKRKSEKKSErkYVHIAFSLTFVLGILVF 384
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550714797 388 ALAANPENRVLGLVSYAWAGFGAAFGpVVLFSVL--WSRMTRNGALAGMIIGAVTVIVWKQFAWLGLYEII 456
Cdd:cd10326 385 GSASNSGSLIDAIFKVAGYTYGPLLG-LFAFGLFtkRAVKDKWVPLVGLLAPVLSYLLVSNSEGFFGYKFG 454
|
|
| SLC5sbd_u2 |
cd11478 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
12-459 |
7.01e-20 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271372 Cd Length: 496 Bit Score: 92.35 E-value: 7.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 12 LVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISeswIAIGLTVGAwINWK 91
Cdd:cd11478 7 AVYFVFVLGIGFYLKRKVKTSEDFFLSGRSLPAWITGLAFISANLGALEIVGMSANGAQYGIA---TVHFYWIGA-IPAM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 92 LVAGRLRVHTEANNNALTLPDYFTGRFednSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAAT 171
Cdd:cd11478 83 VFLGIVMMPFYYGSKVRSVPEYLKLRF---NKSTRLLNAVSFAVMTILMSGINLYALALVLNVLLGWPLWLSIILSAAIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 172 ILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFG---ESLEVIKQKSIENVDMLKGLNFVAI-------VSL 241
Cdd:cd11478 160 LAYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVGGWDglsEKIDANGPPGWNGLSWGPQGSQSTNpmgvnlgLVF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 242 MGW---GLGYFGQPH-ILARFMAADShhtIVHARRISMTWMILCLAGACAVGFFGIAYFNNNPAQAGAVNQNAERVFIEL 317
Cdd:cd11478 240 GLGfvlSFGYWTTNFlEVQRAMAAKD---LSAARRTPLIAAFPKMFIPFLVILPGLIALVLVPELGASGGLDYNQALPYL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 318 AQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRF--MVLLVALVAIALAANPEN 395
Cdd:cd11478 317 MAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYQTYIVKDAPDKHYLKVGRIatVVGVLISIGTAYIASSFN 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550714797 396 RVLGLVSYAWAGFGAAFGPVVLFSVLWSRMTRNGALAGMIIGAVTVIVWKQFAWLGLYEIIPGF 459
Cdd:cd11478 397 NIMDYLQLLFSFFNAPLFATFLLGMFWKRATPWGGFWGLLAGTASAIVLYGLYELGLIVYHSDM 460
|
|
| SLC5sbd_vSGLT |
cd10325 |
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ... |
9-476 |
1.45e-18 |
|
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271360 Cd Length: 523 Bit Score: 88.52 E-value: 1.45e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 9 VTFLVYIFGMILIGFLAWRS----TKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGI---SESWI-AI 80
Cdd:cd10325 1 VIFIVYVILIIGLGLWVSREkkggEKDATDYFLAGKSLPWWAIGASLIAANISAEQFIGMSGSGFAIGLaiaSYEWMaAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 81 GLTVGAWInwklvagRLRVHTEanNNALTLPDYFTGRFEDNSRILRIISAVVILLFFTIycASGIVAGARLFESTFGMSY 160
Cdd:cd10325 81 TLIIVAKF-------FLPIFLK--NGIYTMPQFLEERYDGRVRTIMAVFWLLLYVFVNL--TSVLYLGALAIETITGIPL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 161 ETALWAGAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFG---ESLEVIKQKSIENVDML------- 230
Cdd:cd10325 150 TYSIIGLALFAAAYSIYGGLKAVAWTDVIQVVFLVLGGLVTTYIALSLLGGGEgvfAGFTLLAAEAPEHFHMIldksnpe 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 231 -KGLNFVAIVSLMG--W--GLGYFG-QPHILARFMAADSHHT----IVHARRISMTW-MILCLAGACAVgffgiAYFNNN 299
Cdd:cd10325 230 dAYKDLPGIAVLLGglWvaNLSYWGfNQYIIQRALAAKSLSEaqkgIVFAAFLKLLIpFIVVIPGIAAY-----VLASNL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 300 PAQAGAVNQNAERVFIELAQILFnPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRFMV 379
Cdd:cd10325 305 LLPAATGIEKPDQAYPWLLRNLP-TGLKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIPKKASEKQLVNVGRLAA 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 380 LLVALVAIalaanpenrvlgLVSYAWAGFGAAFG--------------PVVLFSVLWSRMTRNGALAGMIIGAVTVIVWK 445
Cdd:cd10325 384 VIALIIAA------------LIAPPLLGLDQAFQyiqeytgfispgilAIFLLGLFWKRATSAGALVAAILSIVLSALFK 451
|
490 500 510
....*....|....*....|....*....|....*
gi 550714797 446 ----QFAWLGLYEIIpgFIFGSLGIVVFSLLGKAP 476
Cdd:cd10325 452 fllpELPFLDRMGYV--FFICVVLIVLVSLLTPKG 484
|
|
| SLC5sbd_NIS-SMVT |
cd11492 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
9-444 |
7.81e-17 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271383 [Multi-domain] Cd Length: 522 Bit Score: 82.92 E-value: 7.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 9 VTFLVYIFGMILIGF---LAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTVG 85
Cdd:cd11492 4 VVFVAMLLISAAIGIyfgFFGGKQKTTEEYLLGGRNMSVFPVALSLIASFISGITLLGTPAEIYYYGTQYWLIVIAYVLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 86 AWINWKL---VAGRLRVhTEANnnaltlpDYFTGRFednSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYET 162
Cdd:cd11492 84 GPITAYIflpVFYNLQL-TSVY-------EYLELRF---NRRVRLLASFLFILQMLLYLPIVIYAPALALSQVTGINLHI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 163 ALWAGAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFGESLEVIKQ-KSIE----NVDMLKGLNFVA 237
Cdd:cd11492 153 IILVVGIVCIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVIILGTIDVGGFSEVWEIAEEgGRLEffnfDPDPTVRHTFWS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 238 IV-SLMGWGLGYFG-QPHILARFMaadSHHTIVHARRiSMTWMILCLAGACAVGFF-GIA----YFNNNPAQAGAVnQNA 310
Cdd:cd11492 233 LViGGTFTWLSLYGvNQTQVQRYL---SLPSLKSAKK-ALWLNIVGLILILSLCCFtGLViyakYHDCDPLTAGLI-KKP 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 311 ERVFIELA-QILFN-PWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRFMVLLVALVAIA 388
Cdd:cd11492 308 DQLLPYFVmDVLGHlPGLPGLFVAGIFSAALSTLSSGLNSLAAVILEDFIKPFFKKKLSERQATNIMKLLVVVFGLLCIG 387
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 550714797 389 LAANPEnRVLGLVSYAWAGFGAAFGPVV-LFSV--LWSRMTRNGALAGMIIGAVtVIVW 444
Cdd:cd11492 388 LAFLVE-KLGGVLQLSLSIFGITGGPLLgIFTLgmFFPWANSKGALVGLLVGLI-FMLW 444
|
|
| actP |
PRK09395 |
cation/acetate symporter ActP; |
8-443 |
8.86e-17 |
|
cation/acetate symporter ActP;
Pssm-ID: 236495 Cd Length: 551 Bit Score: 83.10 E-value: 8.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 8 LVTFLVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTVGAW 87
Cdd:PRK09395 37 IIMFLIFVVFTLGITYWAAKRTRSASDFYTAGGGITGFQNGLAIAGDYMSAASFLGISALVFTSGYDGLIYSIGFLVGWP 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 88 INWKLVAGRLRvhteaNNNALTLPDYFTGRFEDNS-RILRIISAVVILLFFTIycaSGIVAGARLFESTFGMSYETALWA 166
Cdd:PRK09395 117 IILFLIAERLR-----NLGKYTFADVASYRLKQGPiRTLSACGSLVVVALYLI---AQMVGAGKLIQLLFGLNYHVAVVL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 167 GAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGG-----FGESLEVIKQK-SIENVDMLKGLNFVAIVS 240
Cdd:PRK09395 189 VGVLMMVYVLFGGMLATTWVQIIKAVLLLSGATFMAFMVMKHVGFsfenlFSEAVAVHPKGlAIMGPGGLVKDPISALSL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 241 LMGWGLGYFGQPHILARFM----AADSHHTIVHArrisMTWMILCLAGACAVGFFGIAYFNNNPA---QAGAVNQNAERV 313
Cdd:PRK09395 269 GLALMFGTAGLPHILMRFFtvsdAKEARKSVFYA----TGFIGYFYILTFIIGFGAIVLVGTNPEfkdAAGALIGGNNMA 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 314 FIELAQI----LFNPWIAGILLSAILAaVMSTLScqlLVCSSAITEDLYKAFLRKG-ASQKELVWVGRFMVLLVALVAIA 388
Cdd:PRK09395 345 AVHLANAvggnLFLGFISAVAFATILA-VVAGLT---LAGASAVSHDLYANVIKKGkATERDELRVSKITTLVLGVVAII 420
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 550714797 389 LAANPENR-VLGLVSYAWAGFGAAFGPVVLFSVLWSRMTRNGALAGMIIGAVTVIV 443
Cdd:PRK09395 421 LGILFEKQnIAFMVGLAFAIAASANFPVLLLSMYWKGLTTRGAVIGGWLGLISAVV 476
|
|
| SLC5sbd_NIS-like_u1 |
cd11493 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
8-459 |
9.01e-17 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271384 [Multi-domain] Cd Length: 479 Bit Score: 82.65 E-value: 9.01e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 8 LVTFLVYIFGMILIGFLAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTVGAW 87
Cdd:cd11493 2 LAVIVLYLLGLPLLGLWLSGRQKSTADYFLGGRSMPWWAVCLSVVATETSTLTFLSIPGLAYGGDLTFLQLALGYILGRI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 88 InwklVAGRLrvhteannnaltLPDYFTGRFEDNSRILRI-------ISAVVILLFFTIYC------ASGIVAGARLFES 154
Cdd:cd11493 82 I----VAFVL------------LPRYFRGEVVSAYELLGQrfgggmqKTASVTFLVTRLLAdgvrlfAAAIPVSMILGAD 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 155 TFGMSYETALWAGAAATILYTFVGGFLAVSWTDTVQASLMIFALILTpIIVIFT--VGGFGESLEVI-KQKSIENVDMLK 231
Cdd:cd11493 146 GVALSYIASILIISVVTLLYTYFGGIRAVVWTDVIQLVVYIGGAVAA-LAYLLGalPADWLQIAAAAgKFHLFDLSDLIL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 232 GLN--FVAIVSLMGWGL---GYFGQPHILA-RFMAADShhtIVHARR--ISMTWMILCLAGACAVGFFGIAYFNNNPAQA 303
Cdd:cd11493 225 GLTspYTFWAAIIGGALlsmASHGTDQLMVqRLLACRN---LRDAQKalIGSGVVVFPQFALFLLIGLLLYVYYGGASLA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 304 GAVNQNAERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGRFMVLL-- 381
Cdd:cd11493 302 ALGLGSPDEVFPYFIVHELPAGLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWKRRRLSDEKLLRASRLLTLVwa 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 382 -VALVAIALAANPENRV----LGLVSYAWAGFGAAFgpvvLFSVLWSRMTRNGALAGMIIGAVTVIVWKQFAWLGLYEII 456
Cdd:cd11493 382 vVLVGIALLFQYTDQPVvelgLSIASFTYGGLLGVF----LLGLLTRRASQRDAIAAFIVGFLVMLLLIFGVKFLGLLFA 457
|
...
gi 550714797 457 PGF 459
Cdd:cd11493 458 LAF 460
|
|
| SLC5sbd_YidK |
cd10328 |
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ... |
14-376 |
9.57e-17 |
|
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271362 Cd Length: 472 Bit Score: 82.58 E-value: 9.57e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 14 YIFGMILIGFLAWRSTKNFD-----DYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGIS----ESWIAIGLTV 84
Cdd:cd10328 1 FLLFTALVALISWYKTRGDDlsssdGYFLAGRSLTGVVIAGSLLLTNLSTEQLVGLNGQAYALGMSvmawEVTAAIALII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 85 GAWInwkLVAGRLRvhteanNNALTLPDYFTGRFEDNSR----ILRIISAVVILLFFTIYcaSGIVAGARLF--ESTFGM 158
Cdd:cd10328 81 LALV---FLPRYLK------GGITTIPEFLEERYDETTRrivsILFLLGYVVILLPIVLY--SGALALNSLFdvSELLGI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 159 SYETALWAGAAAT----ILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGG--FGESLEVIKQKSIENVDMLKG 232
Cdd:cd10328 150 SYFQALWLLVWLIgiigAIYAIFGGLKAVAVSDTINGVGLLIGGLLIPILGLIALGDgsFLAGLDTLLTAHPEKLNAIGG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 233 LN----FVAI------VSLMGWGLGYFgqphILARFMAADS-----HHTIVHARRISMTWMILCLAGACAVGFFgiayfn 297
Cdd:cd10328 230 ADspvpFSTLftgmllVNLFYWCTNQA----IIQRALAAKNlkegqKGVLLAGFFKLLVPLILVLPGIIAFHLY------ 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550714797 298 nnpaqaGAVNQNAERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVGR 376
Cdd:cd10328 300 ------GDGLENADMAYPTLVADVLPKWLSGFFAAVLFGAILSSFNSALNSAATLFSLDIYKPIINKNATDKQLVKVGK 372
|
|
| PRK10484 |
PRK10484 |
putative transporter; Provisional |
8-376 |
7.91e-14 |
|
putative transporter; Provisional
Pssm-ID: 236699 [Multi-domain] Cd Length: 523 Bit Score: 73.76 E-value: 7.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 8 LVTFLVYIFGMILIGFLAWRSTKNFD-----DYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGIS----ESWI 78
Cdd:PRK10484 1 MLTILSFLGFTLLVAVISWWKTRKTDtsssdGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSvmawEVTA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 79 AIGLTVGAWInwkLVAGRLRvhteanNNALTLPDYFTGRFEDNSR----ILRIISAVVILLFFTIYcaSGIVAGARLFE- 153
Cdd:PRK10484 81 AIALIILALI---FLPRYLK------SGITTIPDFLEERYDKTTRrivsILFLIGYVVSFLPIVLY--SGALALNSLFHv 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 154 -STFGMSYETALW----AGAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTV--GGFGESLEVIKQKSIEN 226
Cdd:PRK10484 150 sELLGISYGAAIWllvwLIGIIGAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLIALgdGSFMQGLEQLTTVHPEK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 227 VDMLKGLN----FVAI------VSLMGWGLG-YFGQPHILARFMAADSHHTIVHARRISMTWMILCLAGACAVGFFGIAY 295
Cdd:PRK10484 230 LNSIGGATdpvpFPTLftglilVNLFYWCTNqSIVQRALGAKNLAEGQKGALLAAFFKLLGPLILVLPGIIAFHLYGDGL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 296 fnnnpaqagavnQNAERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKGASQKELVWVG 375
Cdd:PRK10484 310 ------------PNADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYKPIINPNASEKQLVKVG 377
|
.
gi 550714797 376 R 376
Cdd:PRK10484 378 K 378
|
|
| SLC5sbd_NIS |
cd11503 |
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ... |
30-376 |
5.07e-10 |
|
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271393 Cd Length: 535 Bit Score: 61.78 E-value: 5.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 30 KNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTVGAWINWKL---VAGRLRVHTEAnnn 106
Cdd:cd11503 28 RSADDFFTGGRGLSAVPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNSLMTAVLfmpVFYRLGITSTY--- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 107 altlpDYFTGRFEDNSRILRIISAVVILLFFTiycasGIV--AGARLFESTFGMSYETALWAGAAATILYTFVGGFLAVS 184
Cdd:cd11503 105 -----QYLEMRFSRAVRLCGTLQFIVATMLYT-----GIViyAPALILNQVTGLDIWASLFSTGIICTFYTTVGGMKAVI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 185 WTDTVQASLMIFALILTPIIVIFTVGGFGESLEVIKQKSIEN-----VDMLKGLNFVAIV--SLMGWGLGYFGQPHILAR 257
Cdd:cd11503 175 WTDVFQVVVMLSGFWAVLIRGVILVGGPRRVLEIAQNHSRINfmdfdPDPRRRYTFWTFVvgGTLVWLSMYGVNQAQVQR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 258 FMAADSHHTIVHARRISMTWMILCLAGACAVGFFGIAYFNN-NPAQAGAVNQNAERVFIELAQILFN-PWIAGILLSAIL 335
Cdd:cd11503 255 YVACRTEKQAKLALLVNQVGLCLIVSSAATCGIVMFVYYSNcDPLLIGRISAPDQYMPYLVLDIFEDlPGVPGLFLACAY 334
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 550714797 336 AAVMSTLSCQLLVCSSAITEDLYKAFLRkGASQKELVWVGR 376
Cdd:cd11503 335 SGTLSTASTSINAMAAVTVEDLIKPRLP-TIAPRKLVFISK 374
|
|
| SLC5sbd_SGLT4 |
cd11488 |
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ... |
12-463 |
5.33e-10 |
|
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.
Pssm-ID: 271380 Cd Length: 605 Bit Score: 61.87 E-value: 5.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 12 LVYIFGMILIGFLAWRSTK----NFDDYILGGRSLgpmvTALSAGASDMSGWLLMGLpgaiFIsGISESWIAIGLTVGAW 87
Cdd:cd11488 4 VVVVYFVFVLAVGIWSSIRasrgTVGGYFLAGRSM----TWWPIGASLMSSNVGSGL----FI-GLAGTGAAGGLAVGGF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 88 ---INWKLVA-GRLRVHTEANNNALTLPDYFTGRFeDNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETA 163
Cdd:cd11488 75 ewnAAWVLIAlGWIFVPVYIAAGVVTMPEYLKKRF-GGQRIRIYMSVLSLILYIFTKISTDIFSGALFIQVSLGWNLYLS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 164 LWAGAAATILYTFVGGFLAVSWTDTVQASLMIF-ALILtpIIVIFTVGGFGESLEVIKQKSIENVDMLK----------- 231
Cdd:cd11488 154 TVILLAVTALYTIAGGLTAVIYTDALQTVIMVIgAFVL--MFIAFDKVGWYPGLEQQYEKAIPALTVPNttchlprsdaf 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 232 --------------GLNFvAIVSLMGWglGYFGQPHILARFMAADShhtIVHARRIS--------MTWMILCLAGACAVG 289
Cdd:cd11488 232 hifrdpvtgdipwpGLIF-GLTVLATW--VWCTDQVIVQRSLSAKN---LSHAKGGSvlggylkiLPMFFVVMPGMISRA 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 290 FFGIAYFNNNPAQ----AGAVNQNAERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFlRKG 365
Cdd:cd11488 306 LFPDEVGCVDPDEcqkiCGAKVGCSNIAYPKLVVELMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQRI-RRR 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 366 ASQKELVWVGR----FMVLLVALVAIALAANPENRVLGLVSYAWAGFGAAFGPVVLFSVLWSRMTRNGALAGMIIGAVtv 441
Cdd:cd11488 385 ASEQELMVVGRvfilLLVVISILWIPIIQTANSGQLFDYIQAVTSYLSPPITAVFILAIFWKRVNEPGAFWGLMVGLV-- 462
|
490 500
....*....|....*....|..
gi 550714797 442 ivwkqfawLGLYEIIPGFIFGS 463
Cdd:cd11488 463 --------VGLVRMIMEFVYGA 476
|
|
| SLC5sbd_SMIT |
cd11491 |
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ... |
8-440 |
1.14e-09 |
|
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271382 Cd Length: 609 Bit Score: 60.65 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 8 LVTFLVYIFGMILIGFLA-WRSTK-NFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGaifisgiseSWIAIGLTVG 85
Cdd:cd11491 2 IAVVALYFILVMCIGIYAmWKSNRsTVSGYFLAGRSMTWLPVGASLFASNIGSEHFIGLAG---------SGAAAGFAVG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 86 AW-INWKLVA---GRLRVHTEANNNALTLPDYFTGRFeDNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYE 161
Cdd:cd11491 73 AFeFNALILLqllGWVFIPVYIRSGVYTLPEYLSKRF-GGHRIQVYLAALSLILYIFTKISVNLYSGALFIQEALGWNLY 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 162 TALWAGAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFGESL--------EVIKQKSIENVD----- 228
Cdd:cd11491 152 VSIILLLGLTALLTVTGGLAAVIYTDTLQAFLMIIGALTLMIISMMEIGGFEGVKsrymlaspNVTSILLTYNLSntnsc 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 229 ----------MLKGLNFvaivSLMGWGLGYFGQPHILARFMAAD--------SHHTIVHARRIS--------MTWMILCL 282
Cdd:cd11491 232 cvhpkkdafkLLRDPTD----EDVPWPGFILGQTPASIWYWCADqvivqrvlAAKSLSHAQGATlmagfiklLPLFIIVI 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 283 AGACAVGFFGIAYFNNNPAQAGAVNQN----AERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLY 358
Cdd:cd11491 308 PGMISRILFPDDIACINPEHCMQVCGSragcSNIAYPRLVMKIMPSGLRGLMMAVMIAALMSDLTSIFNSASTLFTLDVY 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 359 KAFlRKGASQKELVWVGRFMVLLVALVAIALAANPENRVLGLVSYAWAGFGAAFGP----VVLFSVLWSRMTRNGALAGM 434
Cdd:cd11491 388 KLI-RKKASSRELMIVGRIFVAVMVVISIAWIPVIQEMQGGQLYLYIQEVAAYLTPpvasLYLLAIFWKRTTEQGAFYGG 466
|
....*.
gi 550714797 435 IIGAVT 440
Cdd:cd11491 467 MAGFVL 472
|
|
| SLC5sbd_SGLT1 |
cd11486 |
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ... |
12-463 |
3.92e-09 |
|
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.
Pssm-ID: 271379 Cd Length: 636 Bit Score: 59.18 E-value: 3.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 12 LVYIFGMILIGFLAWRSTK--NFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGIS---ESWIAIGLTVga 86
Cdd:cd11486 7 VIYFVVVLAVGVWAMVSTNrgTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAiggFEWNALVVVV-- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 87 winwklVAGRLRVHTEANNNALTLPDYFTGRFeDNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETALWA 166
Cdd:cd11486 85 ------VLGWLFVPIYIKAGVVTMPEYLRKRF-GGQRIQVYLSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 167 GAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFGESLEvikqksienvdmlKGLNfvAIVSLMGWGL 246
Cdd:cd11486 158 LLAITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVGGYDAFME-------------KYMT--AIPSVIGTGN 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 247 GYFGQPHILARfmaADSHHTIVHARRISMTWMILCLAGACAVGFF----------GIAYFNNNPAQAGAVNQNAERV--- 313
Cdd:cd11486 223 STSQEKCYTPR---ADSFHIFRDPITGDLPWPGLLFGLSILTLWYwctdqvivqrCLSAKNMSHVKAGCILCGYLKLlpm 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 314 FI-----ELAQILFNPWIA-----------------------------------GILLSAILAAVMSTLSCQLLVCSSAI 353
Cdd:cd11486 300 FImvmpgMISRILYTDEIAcvvpdeckavcgtevgctniaypklvvelmpnglrGLMLSVMLASLMSSLTSIFNSASTLF 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 354 TEDLYkAFLRKGASQKELVWVGR-FMVLLVALVAI---ALAANPENRVLGLVSYAWAGFGAAFGPVVLFSVLWSRMTRNG 429
Cdd:cd11486 380 TMDIY-TKVRKKASEKELMIAGRlFMLVLIGISIAwvpIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPG 458
|
490 500 510
....*....|....*....|....*....|....
gi 550714797 430 ALAGMIIGAVtvivwkqfawLGLYEIIPGFIFGS 463
Cdd:cd11486 459 AFWGLCVGLL----------VGLARMITEFAYGT 482
|
|
| SLC5sbd_SGLT5 |
cd11489 |
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ... |
35-439 |
5.77e-08 |
|
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212058 Cd Length: 604 Bit Score: 55.33 E-value: 5.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 35 YILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISES---WIAI-GLTVGAWInwklvagrlRVHTEANNNALTL 110
Cdd:cd11489 34 YFLAGRDMAWWPIGASLFASSEGSGLFIGLAGTGAAGGIAVAgfeWNATyALLALAWV---------FVPVYISSGIVTM 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 111 PDYFTGRFeDNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAATILYTFVGGFLAVSWTDTVQ 190
Cdd:cd11489 105 PEYLQRRF-GGERIRMYLSVLSLLLSVFTKISTDLYSGALFVQVCLGWNLYLSTVLMLVVTALYTIAGGLAAVIYTDALQ 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 191 ASLMIFALILTPIIVIFTVGGFGE----SLEVIKQKSIENV-------DMLKgLNFVAIVSLMGWGLGYFGQPHILARFM 259
Cdd:cd11489 184 TLIMVIGAVILTIKAFNQIGGYSNleeaYLQAVPSKIIPNTtchlpraDAMH-LFRDPVTGDLPWTGMTFGLTIMATWYW 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 260 AAD--------SHHTIVHARRIS--------MTWMILCLAGACAVGFFGIAYFNNNPAQ----AGAVNQNAERVFIELAQ 319
Cdd:cd11489 263 CTDqvivqrslSARSLSHAKGGSilasylkmLPMGLIIMPGMISRALFPDDVACVDPEEclrvCGAEVGCSNIAYPKLVM 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 320 ILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAfLRKGASQKELVWVGRFMVLLVALVAIALAANPENRVLG 399
Cdd:cd11489 343 ELMPSGLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWRR-LRPGASERELLLVGRLVTVILVGVSVVWIPILQSSNSG 421
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 550714797 400 LVSYAWAGFGAAFGP----VVLFSVLWSRMTRNGALAGMIIGAV 439
Cdd:cd11489 422 QLYIYIQSVTSYLAPpvtaVFVLAVFWRRANEQGAFWGLMAGLV 465
|
|
| SLC5sbd_SMCT1 |
cd11519 |
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 ... |
24-437 |
8.78e-08 |
|
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. Its expression is under the control of the C/EBP transcription factor. Its tumor-suppressive role is related to uptake of butyrate, propionate, and pyruvate, these latter are inhibitors of histone deacetylases. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. SMCT1 also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and through transporting l-lactate and ketone bodies helps maintain the energy status and the function of neurons. In the kidney its expression is limited to the S3 segment of the proximal convoluted tubule (in contrast to the low-affinity monocarboxylate transporter SMCT2, belonging to a different family, which is expressed along the entire length of the tubule). In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT1 is expressed predominantly in retinal neurons and in retinal pigmented epithelial (RPE) cells. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271402 Cd Length: 542 Bit Score: 54.47 E-value: 8.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 24 LAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTVGAWINWKL---VAGRLRVH 100
Cdd:cd11519 28 FAGGGQQTSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFAFTYAIVVVISAEVflpVFYRLGIT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 101 TEAnnnaltlpDYFTGRFednSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAATILYTFVGGF 180
Cdd:cd11519 108 STY--------EYLELRF---NKCVRLIGTSLFIVQTALYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 181 LAVSWTDTVQASLMIFALILTPIIVIFTVGGFGESLEVIKQKSIENV-----DMLKGLNFVAIV---SLMGWGLGYFGQP 252
Cdd:cd11519 177 KAVIWTDVFQVGIMVAGFVSVIIRAVVLQGGIGTILNDSYYGGRLNFwdfdpNPLQRHTFWTIViggTFTWTSIYGVNQS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 253 HIlARFMAADSHHTIVHARRISMT--WMILCLAGACAVGFFGIaYFNNNPAQAGAVNQNAERVFIELAQILFN-PWIAGI 329
Cdd:cd11519 257 QV-QRYISCKTRFQAKMSLYVNLVglWAILSCAVLSGLAMYSI-YKDCDPWTAKDVSAPDQLMPYLVLDILADyPGLPGL 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 330 LLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKgASQKELVWVGRFMVLLVALVAIALAAnPENRVLGLVSYAWAGFG 409
Cdd:cd11519 335 FVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRS-LSERQLSWISMGMSVFYGALCIGMAG-LASLMGALLQAALSIFG 412
|
410 420 430
....*....|....*....|....*....|.
gi 550714797 410 AAFGPVV---LFSVLWSRMTRNGALAGMIIG 437
Cdd:cd11519 413 MVGGPLLglfALGILFPFANSIGALVGLMSG 443
|
|
| SLC5sbd_SMCT |
cd11505 |
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; ... |
24-444 |
5.67e-07 |
|
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. It also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and, through transporting L-lactate and ketone bodies, helps maintain the energy status and the function of neurons. SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. hSMCT2 is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, SMCT2 may initiate lactate absorption in the early parts of the tubule, SMCT1 in the latter parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271395 Cd Length: 538 Bit Score: 52.20 E-value: 5.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 24 LAWRSTKNFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISESWIAIGLTVGAWINWKL---VAGRLRVH 100
Cdd:cd11505 28 FAGGGQATSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPSEVYRFGASFLIFAFAYLFVVLISSEVflpVFYRLGIT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 101 TEAnnnaltlpDYFTGRFednSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAATILYTFVGGF 180
Cdd:cd11505 108 STY--------EYLELRF---NKPVRLAGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 181 LAVSWTDTVQASLMIFALILTPIIVIFTVGGFGESLEVIKQKSIEN-----VDMLKGLNFVAIV--SLMGWGLGYFGQPH 253
Cdd:cd11505 177 KAVVWTDVFQVGIMVAGFLSVIIQAVVHQGGIHNILNDSYNGSRLNfwdfdPNPLRRHTFWTITvgGTFTWTGIYGVNQS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 254 ILARFMAADSHHTIVHARRISMT--WMILCLAGACAVGFFGIaYFNNNPAQAGAVNQNAERVFIELAQILFN-PWIAGIL 330
Cdd:cd11505 257 QVQRYISCKTRFQAKLSLYFNLLglWAILVCAVFSGLAMYSH-YKDCDPWTAKIVSAPDQLMPYLVLDILADyPGLPGLF 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 331 LSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKgASQKELVWVGRFMVLLVALVAIALAAnPENRVLGLVSYAWAGFGA 410
Cdd:cd11505 336 VACAYSGTLSTVSSSINALAAVTVEDLIKPYFRS-LSEKLSSWISKGLSLLYGAMCIGMAV-AASLMGGLLQAALSIFGM 413
|
410 420 430
....*....|....*....|....*....|....*..
gi 550714797 411 AFGPVV-LFS--VLWSRMTRNGALAGMIIGaVTVIVW 444
Cdd:cd11505 414 VGGPLLgLFSlgILFPFVNSKGALGGLLTG-FAISLW 449
|
|
| SLC5sbd_SMVT |
cd11504 |
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This ... |
34-359 |
5.96e-06 |
|
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This multivitamin transporter SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate, and is essential for mediating biotin uptake into mammalian cells. SMVT is expressed in the placenta, intestine, heart, brain, lung, liver, kidney and pancreas. Biotin may regulate its own cellular uptake through participation in holocarboxylase synthetase-dependent chromatin remodeling events at SMVT promoter loci. The cis regulatory elements, Kruppel-like factor 4 and activator protein-2, regulate the activity of the human SMVT promoter in the intestine. Glycosylation of the hSMVT is important for its transport function. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271394 [Multi-domain] Cd Length: 527 Bit Score: 48.72 E-value: 5.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 34 DYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGiSESWIAI-----GLTVGAWInWKLVAGRLRVHTEAnnnal 108
Cdd:cd11504 35 EFLMADRKMGCLPVALSLLATFQSAVAILGGPSESYTFG-TQYWFLGcsyflGLLIPAHV-FIPVFYRLELTSAY----- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 109 tlpDYFTGRFednSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAATILYTFVGGFLAVSWTDT 188
Cdd:cd11504 108 ---EYLELRF---NKTVRICGTVTFIFQMVIYMGVVLYAPALALNAVTGFNLWISVLAMGVVCTFYTALGGLKAVIWTDV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 189 VQASLMIFALILTPIIVIFTVGGFGESLEVIKQKsienvDMLKGLNFV--AIVSLMGWGLGYFGQPHILA---------- 256
Cdd:cd11504 182 FQTVVMFAGQLAVIIVGSIEAGGIARVWRVAAES-----DRIDGFNLSpdPTIRHTFWTLVVGGVFNMLAlygvnqaqvq 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 257 RFMAADSHHTIVHARRISMTWMILCLAGACAVGFFGIAYFNNNPAQAGAVNQNAERVFIELAQILFN--PWIAGILLSAI 334
Cdd:cd11504 257 RYLSSRTEKQAKRSCYLVFPGQQLSLCIGCLCGLVMFARYHECDPLKNGIVARSDQLVPYFVMDVLDglPGLPGLFIACL 336
|
330 340
....*....|....*....|....*
gi 550714797 335 LAAVMSTLSCQLLVCSSAITEDLYK 359
Cdd:cd11504 337 FSGALSTISSAFNSLATVTMEDLIV 361
|
|
| SLC5sbd_SGLT2 |
cd11487 |
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ... |
12-217 |
7.73e-06 |
|
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212056 [Multi-domain] Cd Length: 583 Bit Score: 48.38 E-value: 7.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 12 LVYIFGMILIGFLAWRSTK----NFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISES---WIAIGLTv 84
Cdd:cd11487 5 VIAAYFLLVIGVGLWSMCRtnrgTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGIAVAgfeWNALFVV- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 85 gawinwkLVAGRLRVHTEANNNALTLPDYFTGRFeDNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSYETAL 164
Cdd:cd11487 84 -------LLLGWLFVPVYLTAGVITMPQYLKKRF-GGQRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASV 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 550714797 165 WAGAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFGESLE 217
Cdd:cd11487 156 IALLGITMIYTVTGGLAALMYTDTVQTFVIIGGACVLMGYAFHEVGGYSALFE 208
|
|
| SLC5sbd_SGLT6 |
cd11490 |
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ... |
8-376 |
1.02e-04 |
|
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271381 Cd Length: 602 Bit Score: 44.90 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 8 LVTFLVYIFGMILIGFLAWRSTK--NFDDYILGGRSLGPMVTALSAGASDMSGWLLMGLPGAIFISGISES---WIAI-G 81
Cdd:cd11490 2 IVVLVLYFLFVLAVGLWSMWKTKrsTVKGYFLAGKDMTWWPVGASLFASNVGSGHFIGLAGSGAAAGIGVVayeWNGLfM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 82 LTVGAWINWKL-VAGRLRvhteannnalTLPDYFTGRFeDNSRILRIISAVVILLFFTIYCASGIVAGARLFESTFGMSY 160
Cdd:cd11490 82 VLVLAWLFLPIyIASRVT----------TMPEYLKKRF-GGKRIQIFLAVLYLFIYIFTKISVDMYAGAVFIQQALQWDL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 161 ETALWAGAAATILYTFVGGFLAVSWTDTVQASLMIFALILTPIIVIFTVGGFgeslEVIKQKSIENVDMLKGLNFVA--- 237
Cdd:cd11490 151 YLAVVGLLGITALYTVAGGLAAVIYTDALQTIIMVIGALILMGYSFAEVGGF----EALLEKYFQAIPSIRSPNSTCgip 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 238 -----------IVSLMGWGLGYFGQP-----------HILARFMAADShhtIVHARRISMT--------WMILCLAGACA 287
Cdd:cd11490 227 redafhifrdpVTSDLPWPGVLLGMSipslwywctdqVIVQRSLAAKN---LSHAKGGSLLaaylkvlpLFMMVIPGMIS 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550714797 288 VGFFGIAYFNNNPAQAGAVNQN----AERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAfLR 363
Cdd:cd11490 304 RILFPDQVACADPEVCKEICGNpsgcSDIAYPKLVMELLPTGLRGLMMAVMLAALMSSLTSIFNSASTIFTMDLWRH-IR 382
|
410
....*....|...
gi 550714797 364 KGASQKELVWVGR 376
Cdd:cd11490 383 PRASEWELMIVGR 395
|
|
| |
