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Conserved domains on  [gi|550718798|ref|WP_022648424|]
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MULTISPECIES: membrane-bound lytic murein transglycosylase EmtA [Enterobacter]

Protein Classification

membrane-bound lytic murein transglycosylase EmtA( domain architecture ID 11487811)

membrane-bound lytic murein transglycosylase EmtA is a murein-degrading enzyme that may play a role in recycling of muropeptides during cell elongation and/or cell division

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
1-203 4.81e-155

membrane-bound lytic murein transglycosylase EmtA;


:

Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 427.07  E-value: 4.81e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798   1 MKLRWFAFLIVLLAGCSSKHDYKNPPWNPEVPVKRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGL 80
Cdd:PRK15470   1 MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  81 MQLKASTAGREVYRYMGWKGQPSTSELKNPERNISMGTAYLSILEHGILKGIDDPEVMQYALVVSYVNGAGALLRTFSSD 160
Cdd:PRK15470  81 MQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 550718798 161 RKEAIEEINDMDKDEFFEHVVKNHPSAQAPRYIWKVQKAMDAM 203
Cdd:PRK15470 161 RKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM 203
 
Name Accession Description Interval E-value
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
1-203 4.81e-155

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 427.07  E-value: 4.81e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798   1 MKLRWFAFLIVLLAGCSSKHDYKNPPWNPEVPVKRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGL 80
Cdd:PRK15470   1 MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  81 MQLKASTAGREVYRYMGWKGQPSTSELKNPERNISMGTAYLSILEHGILKGIDDPEVMQYALVVSYVNGAGALLRTFSSD 160
Cdd:PRK15470  81 MQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 550718798 161 RKEAIEEINDMDKDEFFEHVVKNHPSAQAPRYIWKVQKAMDAM 203
Cdd:PRK15470 161 RKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM 203
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 41-200 2.13e-84

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 246.70  E-value: 2.13e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  41 PISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGREVYRYMGWKGQ-PSTSELKNPERNISMGTA 119
Cdd:cd16893    1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGlPSKSYLFDPENNIDIGTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798 120 YLSILEHGILKGIDDPEVMQYALVVSYVNGAGALLRTFSSDRKEAIEEINDMDKDEFFEHVVKNHPSAQAPRYIWKVQKA 199
Cdd:cd16893   81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLKA 160


                 .
gi 550718798 200 M 200
Cdd:cd16893  161 K 161
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 24-203 6.57e-32

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 115.86  E-value: 6.57e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  24 NPPWNPEVPVKRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgREVYRYMGWKgqPS 103
Cdd:COG0741   88 ELLALAALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATA-RRLGLKLGLG--PS 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798 104 TSELKNPERNISMGTAYLSILeHGILKGiddpevmQYALVV-SYVNGAGALLRTFSSDRKEAIEEIndmdkdeffehvvk 182
Cdd:COG0741  165 PDDLFDPETNIRAGAAYLREL-LDRFDG-------DLVLALaAYNAGPGRVRRWLRRNGDRDGEII-------------- 222

                        170       180
                 ....*....|....*....|.
gi 550718798 183 nhPSAQAPRYIWKVQKAMDAM 203
Cdd:COG0741  223 --PYAETRNYVKKVLANYAIY 241
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 45-168 1.59e-29

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 105.47  E-value: 1.59e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798   45 QAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGRevyryMGWKGQPSTSELKNPERNISMGTAYLSIL 124
Cdd:pfam01464   3 KAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKR-----LGLRVNPGVDDLFDPEKNIKAGTKYLKEL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 550718798  125 ehgiLKGIDDpevMQYALVVSYVNGAGALLRTFSSDRKEAIEEI 168
Cdd:pfam01464  78 ----YKQYGG---DLWLALAAYNAGPGRVRKWIKNAGAKDKKLL 114
 
Name Accession Description Interval E-value
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
1-203 4.81e-155

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 427.07  E-value: 4.81e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798   1 MKLRWFAFLIVLLAGCSSKHDYKNPPWNPEVPVKRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGL 80
Cdd:PRK15470   1 MKLRWFAFLIVLLAGCSSKHDYTNPPWNAKVPVQRAMQWMPISQKAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  81 MQLKASTAGREVYRYMGWKGQPSTSELKNPERNISMGTAYLSILEHGILKGIDDPEVMQYALVVSYVNGAGALLRTFSSD 160
Cdd:PRK15470  81 MQLKASTSGRDVYRRMGWSGEPTTSELKNPERNISMGAAYLNILETGPLAGIEDPKVLQYALVVSYANGAGALLRTFSSD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 550718798 161 RKEAIEEINDMDKDEFFEHVVKNHPSAQAPRYIWKVQKAMDAM 203
Cdd:PRK15470 161 RKKAISKINDLDADEFLEHVARNHPAPQAPRYIYKLEQALDAM 203
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 41-200 2.13e-84

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 246.70  E-value: 2.13e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  41 PISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGREVYRYMGWKGQ-PSTSELKNPERNISMGTA 119
Cdd:cd16893    1 PIVEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPSTAGRDVYRLLGGKGGlPSKSYLFDPENNIDIGTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798 120 YLSILEHGILKGIDDPEVMQYALVVSYVNGAGALLRTFSSDRKEAIEEINDMDKDEFFEHVVKNHPSAQAPRYIWKVQKA 199
Cdd:cd16893   81 YLHILQNRYLKGIKNPKSREYCAIAAYNGGAGNVLRTFSSDRKKAISKINRLSPDEVYQHLTKKLPAAETRNYLKKVLKA 160


                 .
gi 550718798 200 M 200
Cdd:cd16893  161 K 161
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
34-199 1.52e-58

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 187.57  E-value: 1.52e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  34 KRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGREVYRYMGWKGQPSTSELKNPERN 113
Cdd:PRK11671 187 KRAHKYLPMVRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFRMKGKSGQPSRSYLFDPANN 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798 114 ISMGTAYLSILEHGILKGIDDPEVMQYALVVSYVNGAGALLRTFSSDRKEAIEEINDMDKDEFFEHVVKNHPSAQAPRYI 193
Cdd:PRK11671 267 IDTGTAYLAILQNVYLGGITNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINTMSPGDVYQTLTTRHPSAESRRYL 346


                 ....*.
gi 550718798 194 WKVQKA 199
Cdd:PRK11671 347 YKVNTA 352
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 24-203 6.57e-32

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 115.86  E-value: 6.57e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  24 NPPWNPEVPVKRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgREVYRYMGWKgqPS 103
Cdd:COG0741   88 ELLALAALLLRRPLPYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATA-RRLGLKLGLG--PS 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798 104 TSELKNPERNISMGTAYLSILeHGILKGiddpevmQYALVV-SYVNGAGALLRTFSSDRKEAIEEIndmdkdeffehvvk 182
Cdd:COG0741  165 PDDLFDPETNIRAGAAYLREL-LDRFDG-------DLVLALaAYNAGPGRVRRWLRRNGDRDGEII-------------- 222

                        170       180
                 ....*....|....*....|.
gi 550718798 183 nhPSAQAPRYIWKVQKAMDAM 203
Cdd:COG0741  223 --PYAETRNYVKKVLANYAIY 241
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 45-168 1.59e-29

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 105.47  E-value: 1.59e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798   45 QAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGRevyryMGWKGQPSTSELKNPERNISMGTAYLSIL 124
Cdd:pfam01464   3 KAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKR-----LGLRVNPGVDDLFDPEKNIKAGTKYLKEL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 550718798  125 ehgiLKGIDDpevMQYALVVSYVNGAGALLRTFSSDRKEAIEEI 168
Cdd:pfam01464  78 ----YKQYGG---DLWLALAAYNAGPGRVRKWIKNAGAKDKKLL 114
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 44-126 2.04e-18

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 77.94  E-value: 2.04e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  44 EQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgREVYRYMGWKGqPSTSELKNPERNISMGTAYLSI 123
Cdd:cd16896    9 EKYAKEYGVDPLLVAAVIKVESNFNPNAVSSKGAIGLMQIMPETA-EWIAEKLGLED-FSEDDLYDPETNIRLGTWYLSY 86


                 ...
gi 550718798 124 LEH 126
Cdd:cd16896   87 LLK 89
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 54-124 3.83e-18

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 76.10  E-value: 3.83e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550718798  54 PRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgrevyRYMGWKGQpstSELKNPERNISMGTAYLSIL 124
Cdd:cd00254    1 PALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTA-----RDLGRRGV---DDLFDPEENIRAGARYLREL 63
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 37-180 7.46e-18

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 76.36  E-value: 7.46e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  37 MQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgREVYRYMGWKGqPSTSELKNPERNISM 116
Cdd:cd13401    4 LPYRDLVERAAKKNGLDPALVYAIIRQESAFDPDAVSPAGALGLMQLMPATA-KDVAKKLGLPY-YSPRDLFDPEYNIRL 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550718798 117 GTAYLSILeHGILKGiddpevmQYALVV-SYvN-GAGALlrtfssdrKEAIEEINDMDKDEFFEHV 180
Cdd:cd13401   82 GSAYLAEL-LDRFDG-------NPVLALaAY-NaGPGRV--------RRWLKRRGDLDPDLWIETI 130
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 44-155 9.06e-16

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 71.41  E-value: 9.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  44 EQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgrevyRYMGwkgqpsTSELKNPERNISMGTAYLSI 123
Cdd:cd13403    2 KKYAEKYGFDWRLLAAQAYQESRFNPNARSPAGARGLMQLMPSTA-----RELG------VNDRLDPEQNIHAGAKYLRY 70

                         90       100       110
                 ....*....|....*....|....*....|..
gi 550718798 124 LEHGILKGIDDPEVMQYALvVSYVNGAGALLR 155
Cdd:cd13403   71 LRDRFPPDIDEPDRLKFAL-AAYNAGPGHVRD 101
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 34-164 4.76e-15

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 72.40  E-value: 4.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  34 KRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgrevyRYMGwkgqpsTSELKNPERN 113
Cdd:COG4623  259 GRLPPYDPLFEKYAEEYGLDWRLLAALAYQESHWNPRARSPTGARGLMQLMPATA-----KELG------VDDRLDPEQS 327

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550718798 114 ISMGTAYLSILEHGILKGIDDPEVMQYALvVSYVNGAGALLRtfssDRKEA 164
Cdd:COG4623  328 IRAGAKYLRWLYDRFPEAIDEPDRWWFAL-AAYNAGPGHVQD----ARRLA 373
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 39-121 9.52e-08

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 51.22  E-value: 9.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  39 WMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAGREVYRYmGWKGQPSTSELKNPERNISMGT 118
Cdd:PRK11619 479 WNDEFRRYTSGKGIPQSYAMAIARQESAWNPKARSPVGASGLMQIMPGTATHTVKMF-SIPGYSSSSQLLDPETNINIGT 557


                 ...
gi 550718798 119 AYL 121
Cdd:PRK11619 558 SYL 560
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 50-127 3.65e-07

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 46.75  E-value: 3.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  50 WGVSPRLITAIIAVESGGNPTLVSKSN----AVGLMQLKaSTAGREVYRYmgwkGQPSTSELKNPERNISMGTAYLS--I 123
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAINRNKngsyDIGLMQIN-SIWLPELARY----GITREELLNDPCTNIYVGAWILArnI 75


                 ....
gi 550718798 124 LEHG 127
Cdd:cd13400   76 KRYG 79
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 50-88 1.01e-04

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 39.98  E-value: 1.01e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 550718798  50 WGVSPRLITAIIAVESGGNPTLV-SKSNAVGLMQLKASTA 88
Cdd:cd13399    1 YGVPPGILAAILGVESGFGPNAGgSPAGAQGIAQFMPSTW 40
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 34-124 1.48e-04

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 40.66  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  34 KRAMQWMPISEQAGKAWGVSPRLITAIIAVESGGNPTLVSK-----SNAVGLMQLKAstagrevyRYMGWKGQPSTSElk 108
Cdd:cd01021   32 NRLNKYKDCIKQVGKKLCIDPALIAAIISRESRAGAALDKNgwgdhGNGFGLMQVDK--------RYHPPKGAWDSEE-- 101

                         90
                 ....*....|....*.
gi 550718798 109 nperNISMGTAYLSIL 124
Cdd:cd01021  102 ----HIEQATGILIDF 113
PRK10859 PRK10859
membrane-bound lytic murein transglycosylase MltF;
38-154 6.12e-04

membrane-bound lytic murein transglycosylase MltF;


Pssm-ID: 236778 [Multi-domain]  Cd Length: 482  Bit Score: 39.86  E-value: 6.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  38 QWMPISEQAGKawGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLKASTAgrevyRYMGwkgqpstseLKN---PERNI 114
Cdd:PRK10859 289 KYQPLFEKYAG--ELDWRLLAAIAYQESHWNPQATSPTGVRGLMMLTRNTA-----QSMG---------VTDrldPEQSI 352

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 550718798 115 SMGTAYLSILEHGILKGIDDPEVMQYALvVSYVNGAGALL 154
Cdd:PRK10859 353 RGGARYLQDLMERLPESIPEPERIWFAL-AAYNIGYGHML 391
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 63-88 1.05e-03

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 37.50  E-value: 1.05e-03
                         10        20
                 ....*....|....*....|....*.
gi 550718798  63 VESGGNPTLVSKSNAVGLMQLKASTA 88
Cdd:cd16894   16 VESGFNPDAVSSAGAAGLWQFMPATA 41
PHA00368 PHA00368
internal virion protein D
 42-124 2.89e-03

internal virion protein D


Pssm-ID: 222785 [Multi-domain]  Cd Length: 1315  Bit Score: 38.22  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798   42 ISEQAGKAWGVSPRLITAIIAVESGGNPTLVSKSNAVGLMQLkastaGREVYRYMGWKGQPstSELKNPERNISMGTAYL 121
Cdd:PHA00368   14 LFQKAADAHGVSYDLLRKVGWDESRFNPTAKSPTGPKGLMQF-----TKATAKALGLIVDD--DDRLDPELAIDAGARYL 86


                  ...
gi 550718798  122 SIL 124
Cdd:PHA00368   87 ADL 89
SLT COG3953
SLT domain protein [Mobilome: prophages, transposons];
17-114 4.83e-03

SLT domain protein [Mobilome: prophages, transposons];


Pssm-ID: 443153 [Multi-domain]  Cd Length: 325  Bit Score: 37.00  E-value: 4.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550718798  17 SSKHDYKNPPWNPEVPVKRAM-QWMPISEQAGKAW-GVSPRLITAIIAV---ESGGNPTLVSK--SNAV------GLMQL 83
Cdd:COG3953  191 SKALGGAGAGAGGGGGVGGGAgGWGIDIRQAAALGvPVSEAWVDGILRIiqhESGGNPNAINLwdSNAAagtpskGLMQV 270

                         90       100       110
                 ....*....|....*....|....*....|.
gi 550718798  84 KASTagrevyrYMGWKgQPSTSELKNPERNI 114
Cdd:COG3953  271 IPPT-------FNAYK-LPGHGNIYNPVDNI 293
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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