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Conserved domains on  [gi|550734903|ref|WP_022648658|]
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MULTISPECIES: GntR family transcriptional regulator [Enterobacter]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
19-245 2.91e-65

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 202.78  E-value: 2.91e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  19 PDNTPLYLKFAETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQIN-NIFEYSLKE 97
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAePKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  98 ARGFSQQVVLRGKTPNTLWVNKRIVKCPEEIARHLSLAPESDVFLLKRIRYVDDDAVSIEESWVPVGLIPN---PDDIGV 174
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGlleEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550734903 175 SLYDYFRSQ-NIFPQRTRSRVSARMPDSEFQAHIKMDDKIPVLVIKQVALDQQQRPIEYSISYCRSDLYVFV 245
Cdd:COG2188  161 SLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFV 232
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
19-245 2.91e-65

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 202.78  E-value: 2.91e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  19 PDNTPLYLKFAETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQIN-NIFEYSLKE 97
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAePKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  98 ARGFSQQVVLRGKTPNTLWVNKRIVKCPEEIARHLSLAPESDVFLLKRIRYVDDDAVSIEESWVPVGLIPN---PDDIGV 174
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGlleEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550734903 175 SLYDYFRSQ-NIFPQRTRSRVSARMPDSEFQAHIKMDDKIPVLVIKQVALDQQQRPIEYSISYCRSDLYVFV 245
Cdd:COG2188  161 SLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFV 232
PRK11402 PRK11402
transcriptional regulator PhoB;
22-244 4.99e-39

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 135.73  E-value: 4.99e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  22 TPLYLKFAETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQINN-IFEYSLKEARG 100
Cdd:PRK11402   8 QLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSqKVENALLTVSG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903 101 FSQQVVLRGKTPNTLWVNKRIVkCPEEIARHLSLAPESDVFLLKRIRYVDDDAVSIEESWVPVGLIPNPDDI---GVSLY 177
Cdd:PRK11402  88 FTDFGVSQGKATKEKVIEQERV-SAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIyveGSSTY 166

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550734903 178 DYFRSQ-NIFP---QRTRSRVSARMPDSEfqaHIKMDDKIPVLVIKQVALDQQQRPIEYSISYCRSDLYVF 244
Cdd:PRK11402 167 QLFQERfDTRVvsdKKTIDIFAATRPEAK---WLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTL 234
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 108-242 7.43e-36

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 124.25  E-value: 7.43e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  108 RGKTPNTLWVNKRIVKCPEEIARHLSLAPESDVFLLKRIRYVDDDAVSIEESWVPVGLIPNPDDI---GVSLYDYFRSQ- 183
Cdd:pfam07702   2 QGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEdleEGSLYDYLEERy 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 550734903  184 NIFPQRTRSRVSARMPDSEFQAHIKMDDKIPVLVIKQVALDQQQRPIEYSISYCRSDLY 242
Cdd:pfam07702  82 GLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRY 140
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 108-242 6.52e-32

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 113.93  E-value: 6.52e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903   108 RGKTPNTLWVNKRIVKCPEEIARHLSLAPESDVFLLKRIRYVDDDAVSIEESWVPVGLIPN--PDDIGVSLYDYFRSQN- 184
Cdd:smart00866   2 QGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGllEEDLSGSLYEYLEERLg 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550734903   185 ---IFPQRTRSRVSARMPDSEFQAHIKMDDKIPVLVIKQVALDQQQRPIEYSISYCRSDLY 242
Cdd:smart00866  82 lkiVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRF 142
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 24-247 3.10e-27

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 104.87  E-value: 3.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903   24 LYLKFAETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQI-NNIFEYSLKEARGFS 102
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVaARRIDYPLSARTRFS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  103 QQVVLRGKTPNTLWVNKRIVKCPEEIARHLSLAPESDVFLLKRIRYVDDDAVSIEESWVPVGLIPnpdDIGV------SL 176
Cdd:TIGR02325  89 QNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFP---GIGQayaasgSI 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550734903  177 YDYFRSQNIFPQRTRS-RVSARMPDSEFQAHIKMDDKIPVLVIKQVALDQQQRPIEYSISYCRSDLYVFVCE 247
Cdd:TIGR02325 166 TDALREQGVADYRRSStRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFTME 237
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 23-88 2.71e-17

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 73.64  E-value: 2.71e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550734903  23 PLYLKFAETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQIN 88
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
19-245 2.91e-65

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 202.78  E-value: 2.91e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  19 PDNTPLYLKFAETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQIN-NIFEYSLKE 97
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAePKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  98 ARGFSQQVVLRGKTPNTLWVNKRIVKCPEEIARHLSLAPESDVFLLKRIRYVDDDAVSIEESWVPVGLIPN---PDDIGV 174
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGlleEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550734903 175 SLYDYFRSQ-NIFPQRTRSRVSARMPDSEFQAHIKMDDKIPVLVIKQVALDQQQRPIEYSISYCRSDLYVFV 245
Cdd:COG2188  161 SLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFV 232
PRK11402 PRK11402
transcriptional regulator PhoB;
22-244 4.99e-39

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 135.73  E-value: 4.99e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  22 TPLYLKFAETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQINN-IFEYSLKEARG 100
Cdd:PRK11402   8 QLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSqKVENALLTVSG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903 101 FSQQVVLRGKTPNTLWVNKRIVkCPEEIARHLSLAPESDVFLLKRIRYVDDDAVSIEESWVPVGLIPNPDDI---GVSLY 177
Cdd:PRK11402  88 FTDFGVSQGKATKEKVIEQERV-SAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIyveGSSTY 166

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550734903 178 DYFRSQ-NIFP---QRTRSRVSARMPDSEfqaHIKMDDKIPVLVIKQVALDQQQRPIEYSISYCRSDLYVF 244
Cdd:PRK11402 167 QLFQERfDTRVvsdKKTIDIFAATRPEAK---WLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTL 234
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 108-242 7.43e-36

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 124.25  E-value: 7.43e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  108 RGKTPNTLWVNKRIVKCPEEIARHLSLAPESDVFLLKRIRYVDDDAVSIEESWVPVGLIPNPDDI---GVSLYDYFRSQ- 183
Cdd:pfam07702   2 QGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEdleEGSLYDYLEERy 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 550734903  184 NIFPQRTRSRVSARMPDSEFQAHIKMDDKIPVLVIKQVALDQQQRPIEYSISYCRSDLY 242
Cdd:pfam07702  82 GLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRY 140
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 108-242 6.52e-32

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 113.93  E-value: 6.52e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903   108 RGKTPNTLWVNKRIVKCPEEIARHLSLAPESDVFLLKRIRYVDDDAVSIEESWVPVGLIPN--PDDIGVSLYDYFRSQN- 184
Cdd:smart00866   2 QGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGllEEDLSGSLYEYLEERLg 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550734903   185 ---IFPQRTRSRVSARMPDSEFQAHIKMDDKIPVLVIKQVALDQQQRPIEYSISYCRSDLY 242
Cdd:smart00866  82 lkiVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRF 142
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 24-247 3.10e-27

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 104.87  E-value: 3.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903   24 LYLKFAETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQI-NNIFEYSLKEARGFS 102
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVaARRIDYPLSARTRFS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  103 QQVVLRGKTPNTLWVNKRIVKCPEEIARHLSLAPESDVFLLKRIRYVDDDAVSIEESWVPVGLIPnpdDIGV------SL 176
Cdd:TIGR02325  89 QNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFP---GIGQayaasgSI 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550734903  177 YDYFRSQNIFPQRTRS-RVSARMPDSEFQAHIKMDDKIPVLVIKQVALDQQQRPIEYSISYCRSDLYVFVCE 247
Cdd:TIGR02325 166 TDALREQGVADYRRSStRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFTME 237
PRK09764 PRK09764
GntR family transcriptional regulator;
21-244 5.47e-23

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 93.74  E-value: 5.47e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  21 NTPLYLKFAETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQIN-NIFEYSLKEAR 99
Cdd:PRK09764   3 HKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKeERVNYDIFQLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903 100 GFSQQVVLRGKTPNTLWVNKRIVKCPEEIARHLSLAPESDVFLLKRIRYVDDDAVSIEESWVPVGLIPNP--DDIGVSLY 177
Cdd:PRK09764  83 SFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLtwQVMENSKY 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550734903 178 DYFRS-QNIFPQRTRSRVSARMPDSEFQAHIKMDDKIPVLVIKQVALDQQQRPIEYSISYCRSDLYVF 244
Cdd:PRK09764 163 HFIEEvKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKF 230
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 23-88 2.71e-17

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 73.64  E-value: 2.71e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550734903  23 PLYLKFAETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQIN 88
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 24-85 1.77e-13

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 63.40  E-value: 1.77e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550734903   24 LYLKFAETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGT 85
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGT 62
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 44-247 1.92e-13

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 67.49  E-value: 1.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  44 GNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQI-NNIFEYSLKEARGFSQQVVLRGKTPNTLWVNKRIV 122
Cdd:PRK10079  32 GDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVlMRPYDYPLNAQARFSQNLLDQGSHPTSEKLLSVLR 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903 123 KCPEEIARHLSLAPESDVFLLKRIRYVDDDAVSI------EESWVPVGLIPNPDdigvSLYDYFRSQ-NIFPQRTRSRVS 195
Cdd:PRK10079 112 PASGHVADALGITEGENVIHLRTLRRVNGVALCLidhyfaDLTWWPTLQRFDSG----SLHDFLREQlGIALRRSQTRIS 187

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 550734903 196 ARMPDSEFQAHIKMDDKIPVLVIKQV-ALDQQQRPIEYSISYCRSDLYVFVCE 247
Cdd:PRK10079 188 ARRAQAKESQLLEIPNMSPLLCVRTLnHRDGESSPAEYSVSLTRADMIEFTME 240
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
29-87 7.22e-13

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 61.82  E-value: 7.22e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 550734903    29 AETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQI 87
Cdd:smart00345   2 AERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
21-89 1.34e-12

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 64.95  E-value: 1.34e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550734903  21 NTPLYLKFAETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQINN 89
Cdd:COG2186    5 RRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVRE 73
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 15-85 4.77e-12

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 64.85  E-value: 4.77e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550734903  15 RIAAPDNTPLYLKFAETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGT 85
Cdd:COG1167    4 RLDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGT 74
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
20-85 4.92e-12

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 60.96  E-value: 4.92e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550734903  20 DNTPLYLKFAETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGT 85
Cdd:COG1725    7 SGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGT 72
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 27-81 1.54e-07

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 50.79  E-value: 1.54e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550734903  27 KFAETV----KNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVT-----RAR 81
Cdd:PRK03837  13 KLSEEVeerlEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQishgeRAR 76
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
28-94 1.69e-07

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 50.64  E-value: 1.69e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  28 FAEtvKNAVRS---GVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQINNIFEYS 94
Cdd:PRK04984  11 FAE--EYIIESiwnNRFPPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETS 78
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
39-89 4.78e-06

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 46.55  E-value: 4.78e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550734903  39 GVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQINN 89
Cdd:PRK09464  26 GTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQS 76
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
29-99 1.24e-05

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 44.91  E-value: 1.24e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550734903  29 AETVKNAVRSGVLAHGNILPgERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQINNIfeySLKEAR 99
Cdd:COG1802   17 YEALREAILSGELPPGERLS-EAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPL---SPEEIR 83
PRK14999 PRK14999
histidine utilization repressor; Provisional
 23-168 1.45e-05

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 44.92  E-value: 1.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  23 PLYLKFAETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQINN-IFEYSLKEARGF 101
Cdd:PRK14999  12 PFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEpKGQSALFEVRSI 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550734903 102 SQQVVLRGKTPNTLWVNKRIVKCPEEIARHLSLAPESDVFLLKRIRYVDDDAVSIEESWVPVGLIPN 168
Cdd:PRK14999  92 AEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVD 158
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 29-87 2.91e-05

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 43.99  E-value: 2.91e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 550734903  29 AETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQI 87
Cdd:PRK10421   8 ADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
BirA COG1654
Biotin operon repressor [Transcription];
41-83 7.53e-05

Biotin operon repressor [Transcription];


Pssm-ID: 441260 [Multi-domain]  Cd Length: 324  Bit Score: 43.05  E-value: 7.53e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 550734903  41 LAHGNILPGErDLSQLAGVSRITVRKAMQALEEAGVV---TRARGY 83
Cdd:COG1654   13 LADGEFHSGE-ELAEELGVSRAAVWKHIKALRELGYEiesVPGKGY 57
PRK11523 PRK11523
transcriptional regulator ExuR;
24-87 1.69e-04

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 41.75  E-value: 1.69e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550734903  24 LYLKFAETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQI 87
Cdd:PRK11523   9 LYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 29-116 4.37e-04

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 40.52  E-value: 4.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  29 AETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTqinniFEYSLKEARGFSQQVVLR 108
Cdd:PRK09990  13 AERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGS-----FVARLNRVQDASPLMHLF 87


                 ....*...
gi 550734903 109 GKTPNTLW 116
Cdd:PRK09990  88 SSQPRTLY 95
PRK10225 PRK10225
Uxu operon transcriptional regulator;
44-84 2.06e-03

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 38.46  E-value: 2.06e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 550734903  44 GNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYG 84
Cdd:PRK10225  30 GERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAG 70
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
52-82 2.66e-03

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 35.28  E-value: 2.66e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 550734903    52 DLSQLAGVSRITVRKAMQALEEAGVVTRARG 82
Cdd:smart00420  19 ELAELLGVSEMTIRRDLNKLEEQGLLTRVHG 49
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
51-88 2.90e-03

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 37.07  E-value: 2.90e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 550734903  51 RDLSQLAGVSRITVRKAMQALEEAGVVtraRGYGTQIN 88
Cdd:COG1522   23 AELAERVGLSESTVLRRVRRLEEAGVI---RGYGAVVD 57
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 30-114 3.39e-03

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 38.10  E-value: 3.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550734903  30 ETVKNAVRSGVLAHGNILPGERDLSQLAGVSRITVRKAMQALEEAGVVTRARGYGTQInnifeyslkeaRGFSQQVVLRG 109
Cdd:PRK15481  12 DSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVI-----------RGSPSPVALEG 80


                 ....*
gi 550734903 110 KTPNT 114
Cdd:PRK15481  81 GDPGT 85
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 52-82 4.34e-03

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 37.42  E-value: 4.34e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 550734903  52 DLSQLAGVSRITVRKAMQALEEAGVVTRARG 82
Cdd:COG1349   24 ELAERLGVSEETIRRDLAELEEQGLLRRVHG 54
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 52-83 7.96e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 33.56  E-value: 7.96e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 550734903   52 DLSQLAGVSRITVRKAMQALEEAGVV---TRARGY 83
Cdd:pfam08279  18 ELAEKLGVSRRTIRRDIKILEELGVPieaEPGRGY 52
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
52-82 8.92e-03

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 33.77  E-value: 8.92e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 550734903   52 DLSQLAGVSRITVRKAMQALEEAGVVTRARG 82
Cdd:pfam08220  19 ELAELLGVSEMTIRRDLNELEEQGLLTRTHG 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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