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Conserved domains on  [gi|550748356|ref|WP_022648865|]
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MULTISPECIES: 50S ribosomal protein L3 N(5)-glutamine methyltransferase [Enterobacter]

Protein Classification

ribosomal protein L3 N(5)-glutamine methyltransferase( domain architecture ID 11497021)

ribosomal protein L3 N(5)-glutamine methyltransferase specifically methylates the 50S ribosomal protein L3 on Gln-150 using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; does not methylate the translation termination release factors RF1 and RF2; belongs to the class I SAM-dependent methyltransferase superfamily

CATH:  2.20.25.110
EC:  2.1.1.298
Gene Ontology:  GO:0008757|GO:0006479|GO:1904047|GO:0018364
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 13-295 0e+00

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


:

Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 573.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356   13 LHTIQDMLRWSVSRFSAANIWYGHGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRVNERIPVAY 92
Cdd:TIGR03533   1 LHTIRDFLRWAVSRFNAAGLFFGHGTDNAWDEAVYLVLHALHLPLDILEPFLDARLTPSEKERILELIERRIEERIPVAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356   93 LTNKAWFCGHEFYVDERVLVPRSPIGELINNHFDGLINH-QPQHILDMCTGSGCIAIACAYAFPEAEVDAVDISTDALAV 171
Cdd:TIGR03533  81 LTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWLEPePVKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  172 TEHNIEEHGLIHHVTPIRSDLFRDLPTLQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGSDGLKLTRRILACAPDY 251
Cdd:TIGR03533 161 AEINIERHGLEDRVTLIQSDLFAALPGRKYDLIVSNPPYVDAEDMADLPAEYHHEPELALASGEDGLDLVRRILAEAADH 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 550748356  252 LTDDGVLICEVGNSMVHLIEQYPDVPFTWLEFDNGGDGVFMLTK 295
Cdd:TIGR03533 241 LNENGVLVVEVGNSMEALEEAYPDVPFTWLEFENGGDGVFLLTR 284
 
Name Accession Description Interval E-value
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 13-295 0e+00

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 573.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356   13 LHTIQDMLRWSVSRFSAANIWYGHGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRVNERIPVAY 92
Cdd:TIGR03533   1 LHTIRDFLRWAVSRFNAAGLFFGHGTDNAWDEAVYLVLHALHLPLDILEPFLDARLTPSEKERILELIERRIEERIPVAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356   93 LTNKAWFCGHEFYVDERVLVPRSPIGELINNHFDGLINH-QPQHILDMCTGSGCIAIACAYAFPEAEVDAVDISTDALAV 171
Cdd:TIGR03533  81 LTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWLEPePVKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  172 TEHNIEEHGLIHHVTPIRSDLFRDLPTLQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGSDGLKLTRRILACAPDY 251
Cdd:TIGR03533 161 AEINIERHGLEDRVTLIQSDLFAALPGRKYDLIVSNPPYVDAEDMADLPAEYHHEPELALASGEDGLDLVRRILAEAADH 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 550748356  252 LTDDGVLICEVGNSMVHLIEQYPDVPFTWLEFDNGGDGVFMLTK 295
Cdd:TIGR03533 241 LNENGVLVVEVGNSMEALEEAYPDVPFTWLEFENGGDGVFLLTR 284
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 14-266 1.47e-106

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 311.70  E-value: 1.47e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  14 HTIQDMLRWSVSRFSAAniwyghGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRVnERIPVAYL 93
Cdd:COG2890    1 MTIRELLRWAAARLAAA------GVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRA-AGEPLAYI 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  94 TNKAWFCGHEFYVDERVLVPRSPIGELINNHFDGLINHQPQHILDMCTGSGCIAIACAYAFPEAEVDAVDISTDALAVTE 173
Cdd:COG2890   74 LGEAEFYGLEFKVDPGVLIPRPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVAR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356 174 HNIEEHGLIHHVTPIRSDLFRDLPTL-QYDLIVTNPPYVDAEDMSDLPNEYR-HEPELGLASGSDGLKLTRRILACAPDY 251
Cdd:COG2890  154 RNAERLGLEDRVRFLQGDLFEPLPGDgRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRL 233

                        250
                 ....*....|....*
gi 550748356 252 LTDDGVLICEVGNSM 266
Cdd:COG2890  234 LKPGGWLLLEIGEDQ 248
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 15-263 3.96e-68

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 213.49  E-value: 3.96e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  15 TIQDMLRWSVSRFSAaniwyghgtdnPWDEAVQLV-----LPSLYLPLDIPEDmrtarLTSSEKHRIVERVIRRVNeRIP 89
Cdd:PRK09328   3 TIAEALREATARLAS-----------PRLDAELLLahvlgLSRTDLLLNPEEE-----LTPEELERFRALVARRAA-GEP 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  90 VAYLTNKAWFCGHEFYVDERVLVPRsP----IGELINNHFDgliNHQPQHILDMCTGSGCIAIACAYAFPEAEVDAVDIS 165
Cdd:PRK09328  66 LQYILGEAEFWGLDFKVSPGVLIPR-PeteeLVEWALEALL---LKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDIS 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356 166 TDALAVTEHNIeEHGLIHHVTPIRSDLFRDLPTLQYDLIVTNPPYVDAEDMSDLPNEYR-HEPELGLASGSDGLKLTRRI 244
Cdd:PRK09328 142 PEALAVARRNA-KHGLGARVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRI 220

                        250
                 ....*....|....*....
gi 550748356 245 LACAPDYLTDDGVLICEVG 263
Cdd:PRK09328 221 IEQAPRYLKPGGWLLLEIG 239
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 128-265 3.84e-17

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 77.25  E-value: 3.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  128 LINHQPQ----HILDMCTGSGCIAIACAYAFPEAEVDAVDISTDALAVTEHNIEEHGLiHHVTPIRSDLFRDLPTLQYDL 203
Cdd:pfam05175  23 LLEHLPKdlsgKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGL-ENGEVVASDVYSGVEDGKFDL 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550748356  204 IVTNPPYvdaedmsdlpneyrHEpelGLASGSDglkLTRRILACAPDYLTDDGVLICeVGNS 265
Cdd:pfam05175 102 IISNPPF--------------HA---GLATTYN---VAQRFIADAKRHLRPGGELWI-VANR 142
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 136-210 5.51e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 44.34  E-value: 5.51e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550748356 136 ILDMCTGSGCIAIAcAYAFPEAEVDAVDISTDALAVTEHNiEEHGLIHHVTPIRSDLFRDLPTL--QYDLIVTNPPY 210
Cdd:cd02440    2 VLDLGCGTGALALA-LASGPGARVTGVDISPVALELARKA-AAALLADNVEVLKGDAEELPPEAdeSFDVIISDPPL 76
 
Name Accession Description Interval E-value
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 13-295 0e+00

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 573.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356   13 LHTIQDMLRWSVSRFSAANIWYGHGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRVNERIPVAY 92
Cdd:TIGR03533   1 LHTIRDFLRWAVSRFNAAGLFFGHGTDNAWDEAVYLVLHALHLPLDILEPFLDARLTPSEKERILELIERRIEERIPVAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356   93 LTNKAWFCGHEFYVDERVLVPRSPIGELINNHFDGLINH-QPQHILDMCTGSGCIAIACAYAFPEAEVDAVDISTDALAV 171
Cdd:TIGR03533  81 LTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWLEPePVKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  172 TEHNIEEHGLIHHVTPIRSDLFRDLPTLQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGSDGLKLTRRILACAPDY 251
Cdd:TIGR03533 161 AEINIERHGLEDRVTLIQSDLFAALPGRKYDLIVSNPPYVDAEDMADLPAEYHHEPELALASGEDGLDLVRRILAEAADH 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 550748356  252 LTDDGVLICEVGNSMVHLIEQYPDVPFTWLEFDNGGDGVFMLTK 295
Cdd:TIGR03533 241 LNENGVLVVEVGNSMEALEEAYPDVPFTWLEFENGGDGVFLLTR 284
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 15-298 1.56e-134

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 382.86  E-value: 1.56e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356   15 TIQDMLRWSVSRFSAANIWyghgtDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRVNErIPVAYLT 94
Cdd:TIGR00536   2 TIQEFLRWASSALSRAIAR-----ENPWLEALLLLEHDLGRERDLLLAFLTEELTPDEKERIFRLVLRRVKG-VPVAYLL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356   95 NKAWFCGHEFYVDERVLVPRSPIGELINNHFDGLI-NHQPQHILDMCTGSGCIAIACAYAFPEAEVDAVDISTDALAVTE 173
Cdd:TIGR00536  76 GSKEFYGLEFFVNEHVLIPRPETEELVEKALASLIsQPPILHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  174 HNIEEHGLIHHVTPIRSDLFRDLPTLQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGSDGLKLTRRILACAPDYLT 253
Cdd:TIGR00536 156 ENAEKNQLEHRVEFIQSNLFEPLAGQKIDIIVSNPPYIDEEDLADLPNVVRFEPLLALVGGDDGLNILRQIIELAPDYLK 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 550748356  254 DDGVLICEVGNSMVHLIEQYPDVPFTWLEFDNGGDgVFMLTKTQL 298
Cdd:TIGR00536 236 PNGFLVCEIGNWQQKSLKELLRIKFTWYDVENGRD-LNGKERVVL 279
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 14-266 1.47e-106

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 311.70  E-value: 1.47e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  14 HTIQDMLRWSVSRFSAAniwyghGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRVnERIPVAYL 93
Cdd:COG2890    1 MTIRELLRWAAARLAAA------GVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRA-AGEPLAYI 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  94 TNKAWFCGHEFYVDERVLVPRSPIGELINNHFDGLINHQPQHILDMCTGSGCIAIACAYAFPEAEVDAVDISTDALAVTE 173
Cdd:COG2890   74 LGEAEFYGLEFKVDPGVLIPRPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVAR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356 174 HNIEEHGLIHHVTPIRSDLFRDLPTL-QYDLIVTNPPYVDAEDMSDLPNEYR-HEPELGLASGSDGLKLTRRILACAPDY 251
Cdd:COG2890  154 RNAERLGLEDRVRFLQGDLFEPLPGDgRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRL 233

                        250
                 ....*....|....*
gi 550748356 252 LTDDGVLICEVGNSM 266
Cdd:COG2890  234 LKPGGWLLLEIGEDQ 248
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 15-263 3.96e-68

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 213.49  E-value: 3.96e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  15 TIQDMLRWSVSRFSAaniwyghgtdnPWDEAVQLV-----LPSLYLPLDIPEDmrtarLTSSEKHRIVERVIRRVNeRIP 89
Cdd:PRK09328   3 TIAEALREATARLAS-----------PRLDAELLLahvlgLSRTDLLLNPEEE-----LTPEELERFRALVARRAA-GEP 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  90 VAYLTNKAWFCGHEFYVDERVLVPRsP----IGELINNHFDgliNHQPQHILDMCTGSGCIAIACAYAFPEAEVDAVDIS 165
Cdd:PRK09328  66 LQYILGEAEFWGLDFKVSPGVLIPR-PeteeLVEWALEALL---LKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDIS 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356 166 TDALAVTEHNIeEHGLIHHVTPIRSDLFRDLPTLQYDLIVTNPPYVDAEDMSDLPNEYR-HEPELGLASGSDGLKLTRRI 244
Cdd:PRK09328 142 PEALAVARRNA-KHGLGARVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRI 220

                        250
                 ....*....|....*....
gi 550748356 245 LACAPDYLTDDGVLICEVG 263
Cdd:PRK09328 221 IEQAPRYLKPGGWLLLEIG 239
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 68-274 6.68e-64

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 201.93  E-value: 6.68e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356   68 LTSSEKHRIVERVIRRVnERIPVAYLTNKAWFCGHEFYVDERVLVPRsPIGELINNHFDGLINHQPqHILDMCTGSGCIA 147
Cdd:TIGR03534  25 LTPEELAAFDALLARRA-AGEPVAYILGEREFYGLDFKVSPGVLIPR-PETEELVEAALERLKKGP-RVLDLGTGSGAIA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  148 IACAYAFPEAEVDAVDISTDALAVTEHNIEEHGLiHHVTPIRSDLFRDLPTLQYDLIVTNPPYVDAEDMSDLPNEYR-HE 226
Cdd:TIGR03534 102 LALAKERPDARVTAVDISPEALAVARKNARRLGL-ENVEFLQGDWFEPLPSGKFDLIVSNPPYIPEADIHLLDPEVRdFE 180

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 550748356  227 PELGLASGSDGLKLTRRILACAPDYLTDDGVLICEVG----NSMVHLIEQYP 274
Cdd:TIGR03534 181 PRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGydqgEAVRALFEAAG 232
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 37-272 1.15e-27

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 112.27  E-value: 1.15e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  37 GTDNPWDEA---VQLVL--PSLYLPLDIPEDMRTARLTSsekhriVERVIRRVNERIPVAYLTNKAWFCGHEFYVDERVL 111
Cdd:PRK01544  20 GISSPQLEArilLQHVInkPIEYLLINLDEQLNEAEIEA------FEKLLERRLKHEPIAYITGVKEFYSREFIVNKHVL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356 112 VPRSPIGELIN------------------------NHFDGLINHQPQHILDMCTGSGCIAIACAYAFPEAEVDAVDISTD 167
Cdd:PRK01544  94 IPRSDTEVLVDvvfqchsresgnpekkqlnpcfrgNDISSNCNDKFLNILELGTGSGCIAISLLCELPNANVIATDISLD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356 168 ALAVTEHNIEEHGLIHHVTPIRSDLFRDLPTLQYDLIVTNPPYVDAEDMSDLPNE-YRHEPELGLASGSDGLKLTRRILA 246
Cdd:PRK01544 174 AIEVAKSNAIKYEVTDRIQIIHSNWFENIEKQKFDFIVSNPPYISHSEKSEMAIEtINYEPSIALFAEEDGLQAYFIIAE 253

                        250       260
                 ....*....|....*....|....*.
gi 550748356 247 CAPDYLTDDGVLICEVGNSMVHLIEQ 272
Cdd:PRK01544 254 NAKQFLKPNGKIILEIGFKQEEAVTQ 279
PrmC_rel_meth TIGR03704
putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; This protein ...
 65-263 1.48e-23

putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; This protein family is closely related to two different families of protein-(glutamine-N5) methyltransferase. The first is PrmB, which modifies ribosomal protein L3 in some bacteria. The second is PrmC (HemK), which modifies peptide chain release factors 1 and 2 in most bacteria and also in eukaryotes. The glutamine side chain-binding motif NPPY shared by PrmB and PrmC is N[VAT]PY in this family. The protein substrate is unknown. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274733 [Multi-domain]  Cd Length: 251  Bit Score: 96.78  E-value: 1.48e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356   65 TARlTSSEKHRIVERvirRVNErIPVAYLTNKAWFCGHEFYVDERVLVPRSPIGELInnhfDGLINHQPQH-----ILDM 139
Cdd:TIGR03704  23 AAR-TPGELAAMVDR---RVAG-LPLEHVLGWAEFCGLRIAVDPGVFVPRRRTEFLV----DEAAALARPRsgtlvVVDL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  140 CTGSGCIAIACAYAFPEAEVDAVDISTDALAVTEHNIEEHGL-IHHvtpirSDLFRDLPTL---QYDLIVTNPPYVDAED 215
Cdd:TIGR03704  94 CCGSGAVGAALAAALDGIELHAADIDPAAVRCARRNLADAGGtVHE-----GDLYDALPTAlrgRVDILAANAPYVPTDA 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 550748356  216 MSDLPNEYR-HEPELGLASGSDGLKLTRRILACAPDYLTDDGVLICEVG 263
Cdd:TIGR03704 169 IALMPPEARdHEPRVALDGGADGLDVLRRVAAGAPDWLAPGGHLLVETS 217
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 128-269 3.18e-22

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 91.79  E-value: 3.18e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356 128 LINHQPQHILDMCTGSGCIAIACAYAFPEAEVDAVDISTDALAVTEHNIEEHGLiHHVTPIRSDLFRDLPTLQYDLIVTN 207
Cdd:COG2813   45 LPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGL-ENVEVLWSDGLSGVPDGSFDLILSN 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550748356 208 PPYvdaedmsdlpneyrHepelglASGSDGLKLTRRILACAPDYLTDDGVLICeVGNSmvHL 269
Cdd:COG2813  124 PPF--------------H------AGRAVDKEVAHALIADAARHLRPGGELWL-VANR--HL 162
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 82-263 6.87e-21

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 92.07  E-value: 6.87e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  82 RRVNERiPVAYLTNKAWFCGHEFYVDERVLVPRSPIGELInnhfDGLINHQPQH--ILDMCTGSGCIAIACAYAFPEAEV 159
Cdd:PRK14966 204 RRLNGE-PVAYILGVREFYGRRFAVNPNVLIPRPETEHLV----EAVLARLPENgrVWDLGTGSGAVAVTVALERPDAFV 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356 160 DAVDISTDALAVTEHNIEEHGLihHVTPIRSDLF-RDLPTL-QYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGSDG 237
Cdd:PRK14966 279 RASDISPPALETARKNAADLGA--RVEFAHGSWFdTDMPSEgKWDIIVSNPPYIENGDKHLLQGDLRFEPQIALTDFSDG 356

                        170       180
                 ....*....|....*....|....*.
gi 550748356 238 LKLTRRILACAPDYLTDDGVLICEVG 263
Cdd:PRK14966 357 LSCIRTLAQGAPDRLAEGGFLLLEHG 382
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 132-276 1.04e-20

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 88.66  E-value: 1.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356 132 QPQHILDMCTGSGCIAIACAYAFPEAEVDAVDISTDALAVTEHNIEEHGLIHHVTPIRSDL---FRDLPTLQYDLIVTNP 208
Cdd:COG4123   37 KGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDRITVIHGDLkefAAELPPGSFDLVVSNP 116

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550748356 209 PYVDAEDMSDLPNEY----RHEPELGLAsgsdglkltrRILACAPDYLTDDGVLicevgnSMVHLIEQYPDV 276
Cdd:COG4123  117 PYFKAGSGRKSPDEAraiaRHEDALTLE----------DLIRAAARLLKPGGRF------ALIHPAERLAEI 172
PRK14967 PRK14967
putative methyltransferase; Provisional
 136-259 6.53e-18

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 80.87  E-value: 6.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356 136 ILDMCTGSGCIAIACAYAfPEAEVDAVDISTDALAVTEHNIEEHGliHHVTPIRSDLFRDLPTLQYDLIVTNPPYVDAED 215
Cdd:PRK14967  40 VLDLCTGSGALAVAAAAA-GAGSVTAVDISRRAVRSARLNALLAG--VDVDVRRGDWARAVEFRPFDVVVSNPPYVPAPP 116

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 550748356 216 MSdlpneyrhEPELGLA----SGSDGLKLTRRILACAPDYLTDDGVLI 259
Cdd:PRK14967 117 DA--------PPSRGPArawdAGPDGRAVLDRLCDAAPALLAPGGSLL 156
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 128-265 3.84e-17

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 77.25  E-value: 3.84e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  128 LINHQPQ----HILDMCTGSGCIAIACAYAFPEAEVDAVDISTDALAVTEHNIEEHGLiHHVTPIRSDLFRDLPTLQYDL 203
Cdd:pfam05175  23 LLEHLPKdlsgKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGL-ENGEVVASDVYSGVEDGKFDL 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550748356  204 IVTNPPYvdaedmsdlpneyrHEpelGLASGSDglkLTRRILACAPDYLTDDGVLICeVGNS 265
Cdd:pfam05175 102 IISNPPF--------------HA---GLATTYN---VAQRFIADAKRHLRPGGELWI-VANR 142
PRK14968 PRK14968
putative methyltransferase; Provisional
 134-257 7.79e-15

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 71.47  E-value: 7.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356 134 QHILDMCTGSGCIAIACAYAfpEAEVDAVDISTDALAVTEHNIEEHGLIHH-VTPIRSDLFRDLPTLQYDLIVTNPPYvd 212
Cdd:PRK14968  25 DRVLEVGTGSGIVAIVAAKN--GKKVVGVDINPYAVECAKCNAKLNNIRNNgVEVIRSDLFEPFRGDKFDVILFNPPY-- 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 550748356 213 aedmsdLPNEYRHEP----ELGLASGSDGLKLTRRILACAPDYLTDDGV 257
Cdd:PRK14968 101 ------LPTEEEEEWddwlNYALSGGKDGREVIDRFLDEVGRYLKPGGR 143
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
136-209 7.67e-09

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 54.52  E-value: 7.67e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550748356 136 ILDMCTGSGCIAIACAYAFPEaEVDAVDISTDALAVTEHNIEEHGLIHHVtpIRSDLFRDLPTLQYDLIVTNPP 209
Cdd:COG2263   49 VLDLGCGTGMLAIGAALLGAK-KVVGVDIDPEALEIARENAERLGVRVDF--IRADVTRIPLGGSVDTVVMNPP 119
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 136-207 7.60e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 49.48  E-value: 7.60e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550748356  136 ILDMCTGSGCIAIACAYAFpEAEVDAVDISTDALAVTEHNIEEHGLihHVTPIRSDlFRDLPTL--QYDLIVTN 207
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGL--NVEFVQGD-AEDLPFPdgSFDLVVSS 70
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
131-207 1.12e-07

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 52.10  E-value: 1.12e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550748356 131 HQPQHILDMCTGSGCIAIACAYAFPeAEVDAVDISTDALAVTEHNIEEHGLIHHVTPIRSDLFRDLPtlqYDLIVTN 207
Cdd:COG2264  147 KPGKTVLDVGCGSGILAIAAAKLGA-KRVLAVDIDPVAVEAARENAELNGVEDRIEVVLGDLLEDGP---YDLVVAN 219
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 136-273 5.39e-07

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 48.79  E-value: 5.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356 136 ILDMCTGSGCIAIACAYAfpEAEVDAVDISTDALAVTEHNIEeHGLIHHVTPIRSDlFRDLPTL--QYDLIVTNPPY--- 210
Cdd:COG1041   30 VLDPFCGTGTILIEAGLL--GRRVIGSDIDPKMVEGARENLE-HYGYEDADVIRGD-ARDLPLAdeSVDAIVTDPPYgrs 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 550748356 211 --VDAEDMSDLPNEYrhepelgLASGSDGLKLTRRILACAPDYLTDdgvLICEVGNSMVHLIEQY 273
Cdd:COG1041  106 skISGEELLELYEKA-------LEEAARVLKPGGRVVIVTPRDIDE---LLEEAGFKVLERHEQR 160
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 134-205 7.63e-07

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 48.00  E-value: 7.63e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550748356 134 QHILDMCTGSGCIAIACAYAFpEAEVDAVDISTDALAVTEHNIEEHGLIHHVTPIRSDlFRDLP-TLQYDLIV 205
Cdd:COG2230   53 MRVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLAD-YRDLPaDGQFDAIV 123
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 134-198 1.71e-06

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 49.01  E-value: 1.71e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550748356 134 QHILDMCTGSGCIAIACAYAFPEAEVDAVDISTDALAVTEHNIEEHGLiHHVTPIR---SDLFRDLPT 198
Cdd:COG2242  249 DVLWDIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRANARRFGV-PNVEVVEgeaPEALADLPD 315
Methyltransf_15 pfam09445
RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as ...
 136-210 2.02e-06

RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of 7-methylguanosine.


Pssm-ID: 370496  Cd Length: 165  Bit Score: 46.94  E-value: 2.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  136 ILDMCTGSGCIAIACAYAFPEaeVDAVDISTDALAVTEHNIEEHGLIHHVTPIRSDLFRDL-----PTLQYDLIVTNPPY 210
Cdd:pfam09445   4 ILDVFCGGGGNTIQFANVFDS--VISIDINLEHLACAQHNAEVYGVSDRIWLIHGDWFELLaklkfEKIKYDCVFASPPW 81
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
132-207 4.53e-06

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 44.43  E-value: 4.53e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550748356 132 QPQHILDMCTGSGCIAIACAYAFPEAEVDAVDISTDALAVTEHNIEehglihHVTPIRSDLFRDLPTLQYDLIVTN 207
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLP------NVRFVVADLRDLDPPEPFDLVVSN 70
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 136-210 5.51e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 44.34  E-value: 5.51e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550748356 136 ILDMCTGSGCIAIAcAYAFPEAEVDAVDISTDALAVTEHNiEEHGLIHHVTPIRSDLFRDLPTL--QYDLIVTNPPY 210
Cdd:cd02440    2 VLDLGCGTGALALA-LASGPGARVTGVDISPVALELARKA-AAALLADNVEVLKGDAEELPPEAdeSFDVIISDPPL 76
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 157-209 5.76e-06

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 47.48  E-value: 5.76e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 550748356 157 AEVDAVDISTDALAVTEHNIEEHGLIHHVTPIRSDLFRDLPTL-----QYDLIVTNPP 209
Cdd:COG1092  240 KSVTSVDLSATALEWAKENAALNGLDDRHEFVQADAFDWLRELaregeRFDLIILDPP 297
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
132-207 6.24e-06

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 46.68  E-value: 6.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356 132 QPQHILDMCTGSGCIAIACAY--AfpeAEVDAVDISTDALAVTEHNIEEHGLIHHVTpirsdlfrdLPT--LQYDLIVTN 207
Cdd:PRK00517 119 PGKTVLDVGCGSGILAIAAAKlgA---KKVLAVDIDPQAVEAARENAELNGVELNVY---------LPQgdLKADVIVAN 186
N6_Mtase pfam02384
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against ...
 136-232 1.46e-05

N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.


Pssm-ID: 426749 [Multi-domain]  Cd Length: 310  Bit Score: 45.77  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  136 ILDMCTGSGCIAIaCAYAFPEAEVDA----------VDISTDALAVTE---HNIEEHGL-IHHVTPIRSDLFRDLPtlQY 201
Cdd:pfam02384  49 IYDPACGSGGFLI-QAEKFVKEHDGDtndlsiygqeKNPTTYRLARMNmilHGIEYDDFhIRHGDTLTSPKFEDDK--KF 125

                          90       100       110
                  ....*....|....*....|....*....|..
gi 550748356  202 DLIVTNPPYVDAEDMSD-LPNEYRHEPELGLA 232
Cdd:pfam02384 126 DVVVANPPFSDKWDANDtLENDPRFRPAYGVA 157
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
135-217 1.74e-05

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 45.70  E-value: 1.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356 135 HILDMCTGSGCIAIACAYAFPEAEVDAVDISTDALAVTEHNIEEHGLIHHVtpIRSDLFRDLPTlQYDLIVTNPPYVDAE 214
Cdd:PRK09489 199 KVLDVGCGAGVLSAVLARHSPKIRLTLSDVSAAALESSRATLAANGLEGEV--FASNVFSDIKG-RFDMIISNPPFHDGI 275


                 ...
gi 550748356 215 DMS 217
Cdd:PRK09489 276 QTS 278
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 163-210 4.81e-05

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 44.32  E-value: 4.81e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 550748356 163 DISTDALAVTEHNIEEHGLIHHVTPIRSDlFRDL-PTLQYDLIVTNPPY 210
Cdd:COG0116  257 DIDPRAIEAARENAERAGVADLIEFEQAD-FRDLePPAEPGLIITNPPY 304
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
131-181 7.14e-05

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 42.68  E-value: 7.14e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550748356 131 HQPQHILDMCTGSGCIAIACAYAFPEAEVDAVDISTDALAVTEHNIEEHGL 181
Cdd:PRK08287  30 HRAKHLIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQRFGC 80
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 132-205 8.14e-05

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 42.98  E-value: 8.14e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550748356 132 QPQHILDMCTGSGCIAIACAYAFpEAEVDAVDISTDALAVTEHNIEEHGLiHHVTPIRSDL--FRDLPTLQYDLIV 205
Cdd:COG0500   26 KGGRVLDLGCGTGRNLLALAARF-GGRVIGIDLSPEAIALARARAAKAGL-GNVEFLVADLaeLDPLPAESFDLVV 99
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 101-210 1.65e-04

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 42.54  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356 101 GHEFYVD-ERVLVprSP--------IGELINnhfDGlinhqpQHILDMCTGSGCIAIACAYAFPeAEVDAVDISTDALAV 171
Cdd:COG2520  151 GCRFKLDvAKVYF--SPrlaterlrIAELVK---PG------ERVLDMFAGVGPFSIPIAKRSG-AKVVAIDINPDAVEY 218

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 550748356 172 TEHNIEEHGLIHHVTPIRSDlFRDLPTL---QYDLIVTNPPY 210
Cdd:COG2520  219 LKENIRLNKVEDRVTPILGD-AREVAPElegKADRIIMNLPH 259
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 136-207 1.66e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 42.64  E-value: 1.66e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550748356  136 ILDMCTGSGCIAIACAYaFPEAEVDAVDISTDALAVTEHNIEEHGLIHHvtpIRSDLFRDLPTLQYDLIVTN 207
Cdd:pfam06325 165 VLDVGCGSGILAIAALK-LGAKKVVGVDIDPVAVRAAKENAELNGVEAR---LEVYLPGDLPKEKADVVVAN 232
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 125-207 1.68e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 41.13  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356 125 FDGLINHQPQHILDMCTGSGciAIACAYAFPEAEVDAVDISTDALAVTEHNIEEHGLihHVTPIRSDLFR-DLPTLQYDL 203
Cdd:COG2226   15 LAALGLRPGARVLDLGCGTG--RLALALAERGARVTGVDISPEMLELARERAAEAGL--NVEFVVGDAEDlPFPDGSFDL 90


                 ....
gi 550748356 204 IVTN 207
Cdd:COG2226   91 VISS 94
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 137-207 9.02e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 38.12  E-value: 9.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550748356  137 LDMCTGSGCIAIACAYAFPEAEVDAVDISTDALAVTEHNIEEHGL--IHHVTPIRSDLFrDLPTLQYDLIVTN 207
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLlnAVRVELFQLDLG-ELDPGSFDVVVAS 72
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 132-191 1.45e-03

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 39.37  E-value: 1.45e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550748356 132 QPQHILDMCTGSGCIAIA-CAYAFPEAEVDAVDISTDALAVTEHNIEEHGLIHHVTPIRSD 191
Cdd:PRK00216  51 PGDKVLDLACGTGDLAIAlAKAVGKTGEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGD 111
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 136-210 1.63e-03

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 38.88  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550748356  136 ILD-MCtGSGCIAIACA-----------YAFPEAEVDAVDISTDALAVTEHNIEEHGLIHHVTpIRSDLFRDLP--TLQY 201
Cdd:pfam01170  32 LLDpMC-GSGTILIEAAlmganiapgkfDARVRAPLYGSDIDRRMVQGARLNAENAGVGDLIE-FVQADAADLPllEGSV 109


                  ....*....
gi 550748356  202 DLIVTNPPY 210
Cdd:pfam01170 110 DVIVTNPPY 118
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 135-207 6.22e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 36.63  E-value: 6.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550748356  135 HILDMCTGSGCIAIACAY-AFPEAEVDAVDISTDALAVTEHNIEEHGLIhHVTPIRSDLFrDLPTL----QYDLIVTN 207
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEeLGPNAEVVGIDISEEAIEKARENAQKLGFD-NVEFEQGDIE-ELPELleddKFDVVISN 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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