|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
26-438 |
1.28e-119 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 353.04 E-value: 1.28e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 26 IVLGFLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLG 105
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 106 TAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWRSVLLTGA 185
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 186 IAPliltvllalllpesvkflvqrgkdvaqvrriasrfarstldsvtgfflaeekvaskkgsvsqLFSMPWLPGTLMLWV 265
Cdd:cd17365 161 VPP--------------------------------------------------------------LILLPLLRGTLLLWV 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 266 TYFMGLVIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILLLGIEHN 345
Cdd:cd17365 179 TFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPA 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 346 HIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAQLLSMQWQADSILMILSVPAL 425
Cdd:cd17365 259 SLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAA 338
|
410
....*....|...
gi 550766411 426 VAAAATVYKMLYS 438
Cdd:cd17365 339 LGALAVLLLRLRR 351
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
8-407 |
4.78e-100 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 304.66 E-value: 4.78e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 8 DIQQVIDESPFSGFHWLLIVLGFLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMG 87
Cdd:TIGR00895 1 DVQNNIRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 88 RKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAI 167
Cdd:TIGR00895 81 RRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 168 SSWLIPHHGWRSVLLTGAIAPLILTVLLALLLPESVKFLVQRGKDvaQVRRIASRFARSTLDSV-TGFFLAEEKVASKKG 246
Cdd:TIGR00895 161 AGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPE--TVRRIVNAIAPQMQAEAqSALPEQKSTQGTKRS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 247 SVSQLFSMPWLPGTLMLWVTYFMGLVIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAhKVV 326
Cdd:TIGR00895 239 VFKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGP-RVT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 327 ACGFVLTMGLILLLGIEHNHIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAQL 406
Cdd:TIGR00895 318 ALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
.
gi 550766411 407 L 407
Cdd:TIGR00895 398 L 398
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
24-432 |
2.55e-69 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 225.61 E-value: 2.55e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 24 LLIVLGFLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLAS 103
Cdd:PRK11551 15 LTIGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 104 LGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWRSVLLT 183
Cdd:PRK11551 95 LATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 184 GAIAPLILTVLLALLLPESVKFLVQRGKDVAqvrriasrfarstldsvtgfflaeekvasKKGSVSQLFSMPWLPGTLML 263
Cdd:PRK11551 175 GGVGPLLLVPLLMRWLPESRAFAQAAGAGKQ-----------------------------RAPVLRALFGEGRATATLLL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 264 WVTYFMGLVIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILLLGIE 343
Cdd:PRK11551 226 WISYFFTLIVLYFLLNWLPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAGILASLAALAAA 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 344 HNhIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAQLLSMQwQADSILMILSVP 423
Cdd:PRK11551 306 PS-FAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLALG-RSTVGVIGASIP 383
|
....*....
gi 550766411 424 ALVAAAATV 432
Cdd:PRK11551 384 VILVAALAA 392
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-432 |
4.20e-44 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 157.72 E-value: 4.20e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 15 ESPFSGFHWLLIVLGFLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVF 94
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 95 SCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPH 174
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 175 HGWRSVLLTGAIApliltvllalllpesvkflvqrgkdvaqvrriasrfarstldsvtGFFLAeekvaskkgsvsqlfsm 254
Cdd:COG2271 161 FGWRAAFLILGLP---------------------------------------------GLLLA----------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 255 pwLPGTLMLWVTYFMGLVIYYVLLSWMPT-LMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLT 333
Cdd:COG2271 179 --LLRFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLL 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 334 MGLILLLGIEH-NHIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAQLLSMqWQ 412
Cdd:COG2271 257 LAALALLLLALlPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA-TG 335
|
410 420
....*....|....*....|
gi 550766411 413 ADSILMILSVPALVAAAATV 432
Cdd:COG2271 336 YQAAFLLLAALALLAALLAL 355
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
26-432 |
2.98e-41 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 150.06 E-value: 2.98e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 26 IVLGFLVLAIDGFDTAAMGYIAPTLSAE--WGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLAS 103
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 104 LGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPH----HGWRS 179
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLlsgdWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 180 VLLTGAIAPliltvllalllpesvkflvqrgkdvaqvrriasrfarstldsvtgfflaeekvaskkgsvsqLFSMPWLPG 259
Cdd:cd17316 161 LFLIGALPA--------------------------------------------------------------LLALLLRRR 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 260 TLMLWVTYFMGLVIYYVLLSWMPTLMQ-GMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLIL 338
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYLQtVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAL 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 339 LLGIEHNH-IALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAQLLSMQWQADSIL 417
Cdd:cd17316 259 PLFYLLSGsPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPA 338
|
410
....*....|....*
gi 550766411 418 MILSVPALVAAAATV 432
Cdd:cd17316 339 LILALLAIVALIVAL 353
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
22-432 |
5.13e-37 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 139.63 E-value: 5.13e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 22 HWLLIVLGFLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGL 101
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 102 ASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWRSVL 181
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 182 LTGAIAPLILTVllalllpesvkflvqrgkdvaqvrrIASRFARSTldsvtgfflAEEKVASKKGSVSQLFSMPWLPGTL 261
Cdd:COG2223 163 LILGILLLVVAV-------------------------LAWLFLRDP---------PAGAAAAAKASLRDQLEALRDPRFW 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 262 MLWVTYFMGLVIYYVLLSWMPTLMQGM-GYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILLL 340
Cdd:COG2223 209 LLSLLYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 341 GIEHNHIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAQLLSMQWQADSILMIL 420
Cdd:COG2223 289 ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVF 368
|
410
....*....|..
gi 550766411 421 SVPALVAAAATV 432
Cdd:COG2223 369 AVLALVALVLTL 380
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
16-398 |
1.57e-34 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 131.63 E-value: 1.57e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 16 SPFSGFHWLLIVLGFLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFS 95
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 96 CLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHH 175
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 176 GWRSVLLTGAIAPLILTVLLALLLPESVKflvqrgkdvaqvrriasrfarstldsvtgfflaeEKVASKKGSVSQLFSMP 255
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRP----------------------------------AARARLRGSLRELLRRP 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 256 WLPGTLMLWVTYFMGLVIYYVLLSWMptLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMG 335
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLY--LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550766411 336 LILLLGIEHNHIALFGGLiFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVA 398
Cdd:COG2814 286 GLLLLALAGSLWLLLLAL-FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
30-409 |
2.18e-34 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 132.04 E-value: 2.18e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 30 FLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLGTAWA 109
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 110 QSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIP----HHGWRSVLLTGA 185
Cdd:cd17371 85 QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllppEIAWRVLFLLGA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 186 IaPLILTVLLALLLPESVKFLvqrgkdvaqvrriASRFARSTLDsvTGFFLAEekvaskkgsvsqLFSMPWLPGTLMLWV 265
Cdd:cd17371 165 L-PALLVLFIRRFVKEPPQWQ-------------AARAARRHFA--DRPSLRE------------LFSPPLLRTTLLASL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 266 TYFMGLVIYYVLLSWMPTLMQG-MGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILLLGIEH 344
Cdd:cd17371 217 LATGALGGYYGITTWLPSYLTGeRGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLP 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 550766411 345 NHIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAQLLSM 409
Cdd:cd17371 297 LSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATS 361
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
23-432 |
4.41e-28 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 114.20 E-value: 4.41e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 23 WLLIVLGFLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLA 102
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 103 SLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWRSVLL 182
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 183 TGAIApliltvllalllpesvkflvqrgkdvaqvrriasrfarstldsvtGFFLAeekvaskkgsvsqLFSMPWLPGTLM 262
Cdd:cd17319 162 IEGLL---------------------------------------------GLLLA-------------VLWWFYLRQVWG 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 263 LWVTYFMGLVIYYVLLSWMPTLM-QGMGYALAESAWLTSLFTFGGTAGILLAGWMMDR---WEAHKVVACGFVLTMGLIL 338
Cdd:cd17319 184 LALGYFGINYALYGLLTWLPTYLkQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllrGARRLVIIIGLLLAAVGLL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 339 LLGIEHNHIALFgGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAQLLSMQWQADSILM 418
Cdd:cd17319 264 LAYLTTSPVVAV-ILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFL 342
|
410
....*....|....
gi 550766411 419 ILSVPALVAAAATV 432
Cdd:cd17319 343 FLAAVALLAALLVL 356
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-400 |
4.04e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 110.97 E-value: 4.04e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 28 LGFLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLGTA 107
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 108 WAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWRSVLLTGAIA 187
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 188 PLILTVLLALLLPESVKflvqrgkdvaqvrriasrfarstldsvtgffLAEEKVASKKGSVSQLFSMPWLPGTLMLWVTY 267
Cdd:pfam07690 161 SLLAAVLLLLPRPPPES-------------------------------KRPKPAEEARLSLIVAWKALLRDPVLWLLLAL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 268 FMGLVIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHK--VVACGFVLTMGLILLLGIEHN 345
Cdd:pfam07690 210 LLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrlLLALLLLILAALGLLLLSLTL 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 550766411 346 HIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGT 400
Cdd:pfam07690 290 SSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
78-431 |
4.19e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 97.23 E-value: 4.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:cd17324 53 LLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 158 PLGAAGGGAISSWLIPHHGWRSVLLTGAIAPLILTVLLALLLPESVKFLVQRGKDVAQVRRIASRfarstldsvtgffla 237
Cdd:cd17324 133 TLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRN--------------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 238 eekvaskkgsvsqlfsmpwlPGTLMLWVTYFMGLVIYYVLLSWMPTLMQGMGYALAES-AWLTSLFTFGGTAGILLAGWM 316
Cdd:cd17324 198 --------------------PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAiIGLLLLFGVAGVVGSPLAGRL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 317 MDRWEAHKVVACGFVLTMGLILLLGIEHNHIALFGGlIFLMGIAMNGAQSGMQTLAATFYPtECRATGIAWMQGIGRFGG 396
Cdd:cd17324 258 ADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVG-LVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGG 335
|
330 340 350
....*....|....*....|....*....|....*
gi 550766411 397 VAGTMTSAQLLSmQWQADSILMILSVPALVAAAAT 431
Cdd:cd17324 336 ALGAALGGLVLD-HGGWAGVGWVGAALLLLALLLA 369
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
22-305 |
9.43e-22 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 94.88 E-value: 9.43e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 22 HWLLIVLGFLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGL 101
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 102 ASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWRSVL 181
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 182 LTGAIAPLILTVLLALLLPESVKFLVQRGKDVAQVRRIASRFARSTLDSVTGFFLAEEKVASKKGSVSQLFSMPWLPGTL 261
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 550766411 262 MLWVTYFMGLVIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFG 305
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-432 |
3.30e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 91.72 E-value: 3.30e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 30 FLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLGTAWA 109
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 110 QSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHH--GWRSVLLTGAIA 187
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 188 PLILTvllalllpesvkflvqrgkdvaqvrrIASRFARSTLDSVTGFFLAEEKVASKKGSVSQLFSMPWLPGTLMLWVTY 267
Cdd:cd06174 162 ALLAA--------------------------ILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLV 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 268 FMGLVIYYVLLSWMptLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILLLGIEHNHI 347
Cdd:cd06174 216 NLAYYSFSTLLPLF--LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 348 ALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAQLLSMQWQADSILMILSVPALVA 427
Cdd:cd06174 294 LLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLA 373
|
....*
gi 550766411 428 AAATV 432
Cdd:cd06174 374 AILLL 378
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
80-422 |
2.37e-19 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 90.14 E-value: 2.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 80 GPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPL 159
Cdd:PRK03893 76 GAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSI 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 160 GAAGGGAISSWLIPHHGWRSVLLTGaIAPLILTVLLALLLPESVKFLVQRGKDVAQV----------RRI---------- 219
Cdd:PRK03893 156 GAVVAAQVYSLVVPVWGWRALFFIG-ILPIIFALWLRKNLPEAEDWKEKHAGKAPVRtmvdilyrgeHRIinilltlaaa 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 220 ASRFARSTLDSVTGFFLAEEKVASKKGSVSQL--FSMPWLPGTLMLWVTYFMGLVIYYVLLSWMPT-LMQGMGYALAESA 296
Cdd:PRK03893 235 AALWFCFAGNLQNAAIVAVLGLLCAAIFISFMvqSSGKRWPTGVMLMVVVLFAFLYSWPIQALLPTyLKTDLGYDPHTVA 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 297 WLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLIL-LLGIEHNHIALFGGLIFLMGIAMNGAQSGMQTLAATF 375
Cdd:PRK03893 315 NVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLISQLLIIpVFAIGGANVWVLGLLLFFQQMLGQGISGLLPKLIGGY 394
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 550766411 376 YPTECRATGIAWMQGIGRFGGVAGTMTSAqLLSMQWQADSILMILSV 422
Cdd:PRK03893 395 FDTEQRAAGLGFTYNVGALGGALAPILGA-LIAQRLDLGTALASLSF 440
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
23-432 |
5.01e-19 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 88.39 E-value: 5.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 23 WLLIVLGFLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLA 102
Cdd:COG2807 17 WLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 103 SLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRC-RAMAINTMycGFPLGAAGGGAISSWLIPHHGWRSVL 181
Cdd:COG2807 97 LLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVgLMTGLYTA--AMGLGAALAAGLTVPLAAALGWRGAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 182 LTGAIAPLILTVLLALLLPESvkflvQRGKDVAQVRRIASRFARStldsvtgfflaeekvaskkgsvsqlfsmpwlPGTL 261
Cdd:COG2807 175 AVWALLALLALLLWLPLLRRR-----PAAAAAAPAAASLRSLWRS-------------------------------PLAW 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 262 MLWVTYFMGLVIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLtMGLILLLG 341
Cdd:COG2807 219 LLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGL-LGLAGLLG 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 342 IEHNHIALFGGLIFLMGIAMNGAQS-GMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAQLLSMQWQADSILMIL 420
Cdd:COG2807 298 LLLAPGSLPWLWAVLLGLGQGGLFPlALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLL 377
|
410
....*....|..
gi 550766411 421 SVPALVAAAATV 432
Cdd:COG2807 378 AALAVLMLVAGL 389
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
78-397 |
2.53e-18 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 86.99 E-value: 2.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:TIGR00898 146 VFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFF 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 158 PLGAAgGGAISSWLIPHhgWRSVLLTGAiAPLILTVLLALLLPESVKFLVQRG---KDVAQVRRIASRFARSTLDSVTGF 234
Cdd:TIGR00898 226 SLGLV-LLPLVAYFIPD--WRWLQLAVS-LPTFLFFLLSWFVPESPRWLISQGrieEALKILQRIAKINGKKLPAEVLSL 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 235 FLAEEKVASKKG-SVSQLFSMPWLPG-TLMLWVTYFMGLVIYYVLlswmPTLMQGMGYALAESAWLTSLFTFGGtagiLL 312
Cdd:TIGR00898 302 SLEKDLSSSKKQySFLDLFRTPNLRKtTLCLMMLWFTTAFSYYGL----VLDLGNLGGNIYLDLFISGLVELPA----KL 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 313 AGWMMDRWEAHKVVACGFVLTMG--LILLLGIEHNHIALFGGLIFL--MGIAMngAQSGMQTLAATFYPTECRATGIAWM 388
Cdd:TIGR00898 374 ITLLLIDRLGRRYTMAASLLLAGvaLLLLLFVPVDLYFLRTALAVLgkFGITS--AFQMVYLYTAELYPTVVRNLGVGVC 451
|
....*....
gi 550766411 389 QGIGRFGGV 397
Cdd:TIGR00898 452 STMARVGSI 460
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-426 |
3.49e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 85.71 E-value: 3.49e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 30 FLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLGTAWA 109
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 110 QSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWRSVLLTGAIAPL 189
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 190 ILTVLLALLLPESVKFLVQRGKDVAQVRRIASRFARStldsvtgfflaeekvaskkgsvsqlfsmpwlPGTLMLWVTYFM 269
Cdd:cd17325 162 LALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRD-------------------------------RRLLALFLAIFV 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 270 GLVIYYVLLSWMPTLMQG-MGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILLLGIEHNHIA 348
Cdd:cd17325 211 LAFAFGALEPFLPLYAAElGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 349 LFgGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIA---WMQGIGRFGG--VAGTMTSAQLLSMQWQADSILMILSVP 423
Cdd:cd17325 291 LL-LLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGlfnTAFSLGMVLGplLGGFLYDAFGFATPFLAAAALLLLAAV 369
|
...
gi 550766411 424 ALV 426
Cdd:cd17325 370 LFL 372
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
22-442 |
3.53e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 86.06 E-value: 3.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 22 HWLLIVLGFLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGL 101
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 102 ASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRcRAMAINTMYCGFPLGAAGGGAISSWLIPHH---GWR 178
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLGlslSWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 179 SVLLTGAIAPLILTVLlalllpesvkflvqrgkdvaqvrriasrFARSTLDSVTGfflAEEKVASKKGSVSQLFSMPWLp 258
Cdd:COG0738 165 LPYLILAVLLLLLALL----------------------------FLRSKLPEIEE---EEEEAAGSAASLKSLLKNPRL- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 259 gtLMLWVTYFMGLVIYYVLLSWMPT-LMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLI 337
Cdd:COG0738 213 --LLGGLAIFLYVGAEGAIGDWLPLyLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 338 LLLGIEHNHIALFGGLIfLMGIAMNGAQSGMQTLAATFYPTEcRATGIAWMQGIGRFGGVAGTMTSAQLLsmqwQADSIL 417
Cdd:COG0738 291 LLALLAPGPWLALIGLA-LVGLGLSLMFPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLA----DAFGLR 364
|
410 420
....*....|....*....|....*
gi 550766411 418 MILSVPALVAAAATVYKMLYSRSQE 442
Cdd:COG0738 365 AAFLVPLVCYLLILLLALALKRKRR 389
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
78-431 |
5.64e-16 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 79.15 E-value: 5.64e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAP--QRCRAMAIN--TM 153
Cdd:cd17474 53 VAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEggERAKAMGLYeaAL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 154 YCGFPLGAAGGGAISSWliphhGWRSV-LLTGAIAPLILTVLLALLLPESVKflvqrgkdvaqvrriasrfarstldsvt 232
Cdd:cd17474 133 GLGIAVGPLLGGLLAAI-----SWRYPfFLLAALIPVAFLAILFLLPEPKEK---------------------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 233 gfflAEEKVASKKGSVSQLFSMPWLPGTLMLWVTYFmglVIYYVLLSWMPTLMqGMGYALAESA--WLTSLFTFGGTAGI 310
Cdd:cd17474 180 ----AKSSSATKLRDLKKALRGRGLLTFLVSAFLYF---FLYFAFLTYLPFLL-ELLYGISPIIigLLFAGWSVLLALGS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 311 LLAG-WMMDRWEAHKVVACGFVLTMGLILLLGIEHNhIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQ 389
Cdd:cd17474 252 LFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPS-LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYN 330
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 550766411 390 GIGRFGGVAGTMTSAqLLSMQWQADSILMILSVPALVAAAAT 431
Cdd:cd17474 331 FVRFLGQAVGPLLFG-LLLEIFGLSAPFLVGAAIALAAAVLL 371
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
78-437 |
6.34e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 78.75 E-value: 6.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:cd17321 50 LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVV 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 158 PLGAAGGGAISSWLIPHHGWRSVLLTGAIApliltvllalllpesvkflvqrgkdvaqvrriasrfarstldSVTGFFLA 237
Cdd:cd17321 130 GIGAALGPLLGGLLLELFGWRWIFLINVPI------------------------------------------GLVALLLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 238 eekvaskkgsvsqlfsMPWLPGTLMLWVTYFMglviYYVLLSWMPTLMQGM-GYALAESAWLTSLFTFGGTAGILLAGWM 316
Cdd:cd17321 168 ----------------RTFSGAVLAAFLLGAA----LGGLLFLLPLYLQGVlGYSPLQAGLALLPLALAMLVAAPLAGRL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 317 MDRWEAHKVVACGFVLTM-GLILLLGIEHN-HIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRF 394
Cdd:cd17321 228 ADRFGPRLVLVAGLLLTAvGLLLLALLGADsSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQL 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 550766411 395 GGVAGTMTSAQLLS--MQWQADSILMILSVPALVAAAATVYKMLY 437
Cdd:cd17321 308 GGALGVALLGALLTagLSANLGDSGVAALLSAAAAAFAAGFHLAF 352
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
10-292 |
4.63e-14 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 74.24 E-value: 4.63e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 10 QQVIDESPFSGFHW-LLIVLGFLVLAiDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGR 88
Cdd:TIGR01299 153 ELIIQECGHGRFQWaLFFVLGLALMA-DGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGR 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 89 KRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAIS 168
Cdd:TIGR01299 232 KQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMA 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 169 SWLIPH-------------HGWRSVLLTGAIaPLILTVLLALLLPESVKFLVQRGK------------------------ 211
Cdd:TIGR01299 312 WAIIPHygwsfqmgsayqfHSWRVFVIVCAF-PCVFAIGALTFMPESPRFFLENGKhdeawmilklihdtnmrakghpek 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 212 --DVAQVRRIASRFARSTLDSVTG------FFLAEEKVASKKGSVSQLFSMPWLPGTLMLWVTYFMGLVIYYVLLSWMPT 283
Cdd:TIGR01299 391 vfSVNHIKTIHQEDELIEIESDTGtwyqrcFVRALSEGGGIWGNFLRCFNPEVREITIKLMGVWFTLSFGYYGLSVWFPD 470
|
330
....*....|..
gi 550766411 284 L---MQGMGYAL 292
Cdd:TIGR01299 471 MikhLQADDYAA 482
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
37-211 |
2.06e-13 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 71.44 E-value: 2.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 37 GFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLT 116
Cdd:cd17359 14 GYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 117 LWRFLTGLGLGAAMPNAITLISEFAPQRCR--------AMAINTMYCGFPLGAAGGGAISSWLIPHHGWRSVLLTGAIaP 188
Cdd:cd17359 94 IARIIGGLAVGGASALVPMYIAEVAPAEIRgrlvslnqLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAI-P 172
|
170 180
....*....|....*....|...
gi 550766411 189 LILTVLLALLLPESVKFLVQRGK 211
Cdd:cd17359 173 AILFLLGMLFIPESPRWLVSKGK 195
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
26-180 |
5.29e-13 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 69.89 E-value: 5.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 26 IVLGFLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLG 105
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550766411 106 TAWA--QSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWRSV 180
Cdd:cd17380 81 TPLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSV 157
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
78-430 |
3.58e-12 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 67.60 E-value: 3.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:cd17320 53 LYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMIL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 158 PLGAAGGGAISSWLIPHHGWRSVLLTGAIAPLILTVLLALLLPESVKflvqRGKDVAQVRRIASRFARSTLDSVTGFFLa 237
Cdd:cd17320 133 AIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLP----EEKRKPLLSSLLRAYKRVLKNRRFLGYA- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 238 eekvaskkgsVSQLFSMpwlpgtLMLWVTYFMGLVIYyvllswmptlMQGMGYALAESAWLTSLFTFGGTAGILLAGWMM 317
Cdd:cd17320 208 ----------LALGLSF------AGLFAYLAAAPFIY----------IEQLGLSPAQFGLLFALNAIALILGSLLNGRLV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 318 DRWEAHKVVACGFVL----TMGLILLLGIEHNHIALFGGLIFLMGIAMNGAQSGMQTLAATFYPtECRATGIAwMQGIGR 393
Cdd:cd17320 262 RRFGPRRLLRLGLLLllaaALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASA-LLGFLQ 339
|
330 340 350
....*....|....*....|....*....|....*..
gi 550766411 394 FGGVAGTMTSAQLLSMQWQADSILMILSVPALVAAAA 430
Cdd:cd17320 340 FLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLL 376
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
78-433 |
3.73e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 67.60 E-value: 3.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFA--PQRCRAMAINTMYC 155
Cdd:cd17473 54 LAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFegEERAKMLGLQSAAM 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 156 GfpLGAAGGGAISSWLIpHHGWRSVLLTGAIApliltvllalllpesVKFLVqrgkdvaqvrrIASRFARSTldsvtgff 235
Cdd:cd17473 134 S--LGGVVFLLLGGALA-EIGWRAPFLVYLLA---------------LPVLI-----------LVLLFLPEP-------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 236 lAEEKVASKKGSVSQLFSMPWLPgTLMLWVTYFMGLVIYYVLLSWMPTLMQGMGYALAESA-WLTSLFTFGGTAGILLAG 314
Cdd:cd17473 177 -ARKSKSAASPGAATAAALPWKR-VLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIgLALAIASLAGAIGALLFG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 315 WMMDRWEAHKVVACGFVLTMGLILLLGIEHNHIALFGGLIFlMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRF 394
Cdd:cd17473 255 RLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAIL-AGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFL 333
|
330 340 350
....*....|....*....|....*....|....*....
gi 550766411 395 GGVAGTMTSAQLLSMQWQADSILMILSVPALVAAAATVY 433
Cdd:cd17473 334 GQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
36-435 |
1.22e-11 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 66.11 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 36 DGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTL 115
Cdd:PRK12307 30 DGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIML 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 116 TLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLgaagGGAISSWLIPH----HGWRSVLLTGaIAPLIL 191
Cdd:PRK12307 110 TLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGI----GNIIAAYFMPSfaeaYGWRAAFFVG-LLPVLL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 192 TVLLALLLPESVKFLVQRGKDVAQVRRIASRFARSTLDSVtgfflaeekvaskkgsvsqlFSMPWLPGTLMLWVTYFMGL 271
Cdd:PRK12307 185 VIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKGL--------------------FNRAQFPLTLCVFIVLFSIF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 272 VIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLIL-LLGIEHNHIALF 350
Cdd:PRK12307 245 GANWPIFGLLPTYLAGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFpLFRIPQDNYLLL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 351 GGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAQL------------LSMQWQADSILM 418
Cdd:PRK12307 325 GACLFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLgitmglgaaltfIVAFWTATILLI 404
|
410
....*....|....*...
gi 550766411 419 I-LSVPALVAAAATVYKM 435
Cdd:PRK12307 405 IgLSIPDRLKARRESFQS 422
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
78-432 |
1.47e-11 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 65.63 E-value: 1.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGT----------AWAQSLntLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRA 147
Cdd:cd17369 63 VFGHFGDRIGRKKTLVLTLLLMGIATFLIgllptyaqigILAPIL--LVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 148 MAINTMYCGFPLG---AAGGGAISSWLIPHH-----GWRsvlltgaiapliltvllalllpesVKFLvqrgkdVAQVRRI 219
Cdd:cd17369 141 FYGSFPQLGAPVGlllATGVFLLLSALLSDEaflswGWR------------------------IPFL------LSAVLVA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 220 ASRFARSTLDSVTGFFLAEEKVASKKGSVSQLFSMPWLP---GTLMLWVTYfmglVIYYVLLSWMPTLM-QGMGYALAES 295
Cdd:cd17369 191 VGLYIRLRLEETPVFRRAKEAGQVVRAPLVEVLRRHWRAlllAIGLRLAEN----VLFYLFTTFALSYAtQTLGVDRSTV 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 296 AWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLI--LLLGIE-HNHIALFGGLIFLMGIAMNGAQSGMQTLA 372
Cdd:cd17369 267 LLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAfpFFWLLDtGSTWLIVLAAVVVLGVLHGMMYGPQAAFL 346
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550766411 373 ATFYPTECRATG--IAWMQGIGRFGGVAgTMTSAQLLSMQWQADSILMILSVPALVAAAATV 432
Cdd:cd17369 347 AELFPTRVRYTGasLGYQLGAILGGGFA-PLIATALVAATGSWWPVALYLAALAVISLVAAL 407
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
78-386 |
1.54e-11 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 65.76 E-value: 1.54e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNT---LTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAI---N 151
Cdd:pfam00083 65 FAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSvyqLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGslyQ 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 152 TMYCGFPLGAAGGGAISSWLIPHHGWRsVLLTGAIAPLILTVLLALLLPESVKFLVQRGKDVaQVRRIASRFARSTLDSV 231
Cdd:pfam00083 145 LAITFGILLAYIFGLGLNKTSNSDGWR-IPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLE-EAREVLAKLRGVPDVDR 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 232 TgffLAEEKVASKKG------SVSQLFSMPWLPGTLMLWVTYFMGL-------VIYYVllswmPTLMQGMGyaLAESAWL 298
Cdd:pfam00083 223 E---LDEIKDSLEAGqeaekaSWKELFSTKTRRQRLLIGVMLQIFQqltginaIFYYS-----TTIFENLG--LSDSFLV 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 299 TSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILLLGI-----EHNH-----IALFGGLIFLMGIAMnGAQSGM 368
Cdd:pfam00083 293 TIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFVILGIvallgVSKSdwagiVAIVFIALFIAFFAM-GWGPVP 371
|
330
....*....|....*...
gi 550766411 369 QTLAATFYPTECRATGIA 386
Cdd:pfam00083 372 WVIVSELFPLSVRSKAMA 389
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
78-358 |
4.03e-11 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 64.59 E-value: 4.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNT---LTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAmAINTMY 154
Cdd:cd17357 68 ISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSpelLIFGRFLVGIACGLSTGFVPMYLQEISPSELRG-ALGSLT 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 155 C-GFPLGAAGGGAIS--SWLIPHHGWRsVLLTGAIAPLILTVLLALLLPESVKFLVQRGKDVAQVRRIASRFARSTLDSV 231
Cdd:cd17357 147 QiGVTLGILLGQVFGlpSVLGTETLWP-YLLFFPGIPALLQLAALPFFPESPKFLLISKGDEEEAEKSLKFLRGIEDDVD 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 232 TGFFL----AEEKVASKKGSVSQLFSMP--WLPGTLMLWVTYFMGLVIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFG 305
Cdd:cd17357 226 QELEEikkeSEQMGDQKQVSLMQLLRDPslRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFSPQLAEWANLGIGIV 305
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 550766411 306 GTAGILLAGWMMDRWEAHKVVACGFVLTMGLILLLGI-----EHNHIALFGGLIFLMG 358
Cdd:cd17357 306 NVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVflflsEQNSWMSYGCIVAIFL 363
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
78-409 |
4.09e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 64.14 E-value: 4.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGlGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:cd17504 50 ILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG-GAVFPLAFALVREEFPPERVPVAQGILSATF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 158 PLGAAGGGAISSWLIPHHGWRSVLLTGAIAplilTVLLALLLPesvkfLVqrgkDVAQVRRiasrfarstldsvtgffla 237
Cdd:cd17504 129 GIGAGIGLPLGGWIVQHLGWRWIFWTAAPV----AVLLAALVP-----LI----DLRLLRR------------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 238 eekvaskkgsvsqlfsmpwlPGTLMLWVTYFMGLVIYYVLLSWMPTLMQ-----GMGYALAESAWLTSLFTFGGTAGILL 312
Cdd:cd17504 177 --------------------RNVLLANITALLAGFGMFMVFQLLPQLLQlptptGFGLGITEAGLLLLPGALVMLIAGPL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 313 AGWMMDRWEAHKVVACGFVLTMGLILLLGIEHNHIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIG 392
Cdd:cd17504 237 AGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLR 316
|
330
....*....|....*..
gi 550766411 393 RFGGVAGTMTSAQLLSM 409
Cdd:cd17504 317 TIGSAIGPAIAGAILTT 333
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
27-439 |
8.98e-11 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 63.66 E-value: 8.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 27 VLGFLVLAiDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLGT 106
Cdd:cd17363 3 VLGLALMA-DGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 107 AWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPH------------ 174
Cdd:cd17363 82 SFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHygwgfsmgtayq 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 175 -HGWRSVLLTGAIaPLILTVLLALLLPESVKFLVQRGKdvaqvRRIASRFARSTLDSVTGFFLAEEKVAskkgSVSQLFS 253
Cdd:cd17363 162 fHSWRVFVIVCAL-PSVASVVALTFMPESPRFLLEVGK-----HDEAWMILKQVHDTNMRAKGHPERVF----TVSHIKR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 254 MpwlpGTLMLWVTYFMGLVIYYVLLSWMPTLMQGMGYA------------------------------------------ 291
Cdd:cd17363 232 M----NTLFLAIVWFTMSFSYYGLTVWFPDMIKYLQFEdslfeecyfedvtstntffenctfintvfyntdlfeykfids 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 292 -------------------LAESAWLTSLFTFGGTAGIL----LAGWMMDRWEAHKVVACGFVLT--MGLILLLGIEHNH 346
Cdd:cd17363 308 rflnstfflkekcgchlndDEENAYLIYLVSFLGSLSVLpgniVSALLMDKIGRLKMIGGSMLLSavCCFFLFFGNSESA 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 347 IALFGGLIFLMGIAmngAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAQLLSMqwqADSILMILSVPALV 426
Cdd:cd17363 388 MIGLQCLFCGVSIA---AWNALDVVTVELYPTDKRATAFGFLNGLCKLAAILGNSIFGSFVGI---TKVIPILLASAALV 461
|
490
....*....|...
gi 550766411 427 AAAATVYKMLYSR 439
Cdd:cd17363 462 CGGLLALKLPETR 474
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
25-286 |
1.13e-10 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 63.40 E-value: 1.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 25 LIVLGFLVLAiDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASL 104
Cdd:cd17438 1 FFVLGLALMA-DGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 105 GTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWR------ 178
Cdd:cd17438 80 LSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGWGfsmgtn 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 179 ------SVLLTGAIAPLILTVLLALLLPESVKFLVQRGKDVAqvrriasrfARSTLDSVTGFFLAEEKVASKKGSVSQLF 252
Cdd:cd17438 160 yhfhswRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDE---------AWMILKNIHDTNMRAKGTPEKVFTVSNIK 230
|
250 260 270
....*....|....*....|....*....|....
gi 550766411 253 SMpwlpGTLMLWVTYFMGLVIYYVLLSWMPTLMQ 286
Cdd:cd17438 231 RK----NTLFLAVVWFTMAFSYYGLTVWFPDMIR 260
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
36-206 |
1.51e-10 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 62.52 E-value: 1.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 36 DGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTL 115
Cdd:cd17441 11 DAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 116 TLWRFLTGLGLGAAmPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWRSVLLTGAIaPLILTVLL 195
Cdd:cd17441 91 LVLRGLVGFGIGGV-PQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSAL-PLLIFAVL 168
|
170
....*....|.
gi 550766411 196 ALLLPESVKFL 206
Cdd:cd17441 169 CFWLPESARYW 179
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
27-286 |
1.82e-10 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 62.74 E-value: 1.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 27 VLGFLVLAiDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLGT 106
Cdd:cd17439 3 VLGLALMA-DGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 107 AWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPH------------ 174
Cdd:cd17439 82 SFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHygwsfqmgsayq 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 175 -HGWRSVLLTGAIaPLILTVLLALLLPESVKFLVQRGKDVAqvrriasrfARSTLDSVtgfflaEEKVASKKGSVSQLFS 253
Cdd:cd17439 162 fHSWRVFVLVCAF-PSVFAIGALTTMPESPRFFLENGKHDE---------AWMVLKQV------HDTNMRAKGHPERVFS 225
|
250 260 270
....*....|....*....|....*....|....*
gi 550766411 254 MPWLPG--TLMLWVTYFMGLVIYYVLLSWMPTLMQ 286
Cdd:cd17439 226 VTHIKRriTLMMMAVWFTMSFSYYGLTVWFPDMIK 260
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
44-363 |
2.25e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 61.87 E-value: 2.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 44 GYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTG 123
Cdd:cd17475 16 PALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 124 LGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWRSVLLTGAIAPLILTVLLALLLPESV 203
Cdd:cd17475 96 AGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 204 KFLVQRGKDVAQVRRIASRFARSTLdsvtgfflaeekvaskkgsvsqlfsmpWLPGtlmlWVTYFMGLVIYYVLLSWMPT 283
Cdd:cd17475 176 AASAATESASTLLRSLKEVLRNRDV---------------------------WLIA----IAGALLVAPQFALLTFLLLF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 284 LMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEA--HKVVACGFVLTMGL---ILLLGIEHNHIALFGGLIFLMG 358
Cdd:cd17475 225 LHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGgrRRPVLVITAAIAAAallVLSLLSPGTPLWLLVLLLILLG 304
|
....*
gi 550766411 359 IAMNG 363
Cdd:cd17475 305 LFAIG 309
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
261-435 |
7.46e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 60.37 E-value: 7.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 261 LMLWVTYFMGLVIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILLL 340
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 341 GIEHNhIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAqLLSMQWQADSILMIL 420
Cdd:COG2814 93 ALAPS-LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGG-LLADLFGWRWVFLVN 170
|
170
....*....|....*
gi 550766411 421 SVPALVAAAATVYKM 435
Cdd:COG2814 171 AVLALLALLLLLRLL 185
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
47-406 |
9.89e-10 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 60.08 E-value: 9.89e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 47 APTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGL 126
Cdd:TIGR00881 18 MPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 127 GAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGG-GAISSWLIPHHGWRSVL-LTGAIAPLILTVLLALLLPESVK 204
Cdd:TIGR00881 98 GMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLpPLVLFGIAELYSWHWVFiVPGIIAIIVSLICFLLLRDSPQS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 205 FlvqrGKDVAQVRRIasrfarstlDSVTGFFLAEEKVASKKGSVSQlfsmpWLPGTLMLWVTYFMGLVIYYVL---LSWM 281
Cdd:TIGR00881 178 C----GLPPAEEMPN---------EEPDGDAEKKEEELTKKQIFLQ-----YVLLNKVLWYISLGYVFVYVVRtgiLDWS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 282 PT-LMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLIL-LLGIEHNHIA-LFGGLIFLMG 358
Cdd:TIGR00881 240 PLyLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVsLLVYWLNPAAnPLMDLICLFA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 550766411 359 IAM--NGAQSGMQTLAATFYPTECRATGIAWmqgIGRFGGVAGTMTSAQL 406
Cdd:TIGR00881 320 LGFlvYGPQMLIGVIASELAPKKAAGTAAGF---VGFFAYLGGILAGLPL 366
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
80-127 |
2.59e-09 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 58.80 E-value: 2.59e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 550766411 80 GPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLG 127
Cdd:PRK15402 69 GPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLC 116
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
22-430 |
2.71e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 58.82 E-value: 2.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 22 HWLLIVLGFLVLAID-GFDTAAMGYIAPtLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFG 100
Cdd:cd17355 1 GWVVLAVTFLILILSwGIRYYFGVFIIP-IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 101 LASLGTAWAQSLNTLTL-WRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWRS 179
Cdd:cd17355 80 AGLVLLALATSLWQLYLlWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 180 VLLTGAIApliltvlLALLLPESVKFLVQRGKDVAqvrriasrfarstldsvtgffLAEEKVASKKGSVSQLFSMPWLPG 259
Cdd:cd17355 160 ALLVLALL-------ALLVLVPVLLLLRRRPADLA---------------------LRAYDDASPASPGSTLKEALRSAS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 260 TLMLWVTYFMGLVIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILL 339
Cdd:cd17355 212 FWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLAL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 340 LGIEHNHIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAQLLSMqwqADSILMI 419
Cdd:cd17355 292 LLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDR---TGSYTAA 368
|
410
....*....|.
gi 550766411 420 LSVPALVAAAA 430
Cdd:cd17355 369 WALAVALGLIA 379
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
78-400 |
3.76e-09 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 57.96 E-value: 3.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:cd17502 49 IYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 158 PLGAAGGGAISSWLIPHHGWRSV----LLTGAIApliltvllalllpesvkflvqrgkdvaqvrriasrfarstldsvtg 233
Cdd:cd17502 129 GIASVAGPLIGGAFTDHLSWRWCfyinLPIGGLA---------------------------------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 234 FFLaeekvaskkgsvsqlfsmpwLPGTLMLWVTYFMGLVIYYVLLSWMPTLMQG-MGYALAESAWLTSLFTFGGTAGILL 312
Cdd:cd17502 163 LAL--------------------LRTILLSSIFGFLFGGALFGLIYYLPLYFQLvLGDSATKSGVRLLPLIIGLVIGSII 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 313 AGWMMDRWEAHK--VVACGFVLTMGLILLLGI-EHNHIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQ 389
Cdd:cd17502 223 SGALISKTGRYKplIVIGTILMSVGAGLLTTLtLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNT 302
|
330
....*....|.
gi 550766411 390 GIGRFGGVAGT 400
Cdd:cd17502 303 FFRSLGGTLGV 313
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
78-202 |
4.30e-09 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 57.97 E-value: 4.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAmAINTMycgF 157
Cdd:cd17315 53 FGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRG-ALGTL---N 128
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 550766411 158 PLGAAGGGAISSWL------IPHHGWRsVLLTGAIAPLILTVLLALLLPES 202
Cdd:cd17315 129 QLMITFGILLAYLLglalslSPPGWWR-LMFALAAVPALLQLLLMFFLPES 178
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
78-438 |
5.25e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.60 E-value: 5.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:cd17489 50 FAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLAT 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 158 PLGAAGGGAISSWLIPHHGWRSVLLTGAIAPLILTVLLalllpesvkFLVQRGKDVAQVRRIASRFARSTLDSVTGffla 237
Cdd:cd17489 130 TLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV---------FLVKDPPPVAAEEAEAGTRAFRRLVEKKV---- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 238 eekvaskkgsvsqlfsmpWLPGTLMLWVTYFMGLVIYYVLLswmptlmqgmgYALAESAWLTSLFtFGGTAGILL----- 312
Cdd:cd17489 197 ------------------LPPALILFLASIAYGAISTFLPL-----------YAAERGISNAGLF-FTVYAIALLlsrpf 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 313 AGWMMDRWEAHKVVACGFVLTMGLILLLGIEHNHIALFGGLIfLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIG 392
Cdd:cd17489 247 SGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAV-LYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFF 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 550766411 393 RFGGVAGTMTSAQLlsMQWQADSILMILSvpALVAAAATVYKMLYS 438
Cdd:cd17489 326 DLGIGLGGLLLGLV--AELFGYRAMFLLA--AVVVLLALVLYIFLL 367
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
263-433 |
5.25e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 57.43 E-value: 5.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 263 LWVTYFMGLVIYYVLLSWMP-TLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILLLG 341
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 342 IEHNHIALFgGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAqLLSMQWQADSILMILS 421
Cdd:pfam07690 81 FASSLWLLL-VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGG-LLASLFGWRAAFLILA 158
|
170
....*....|..
gi 550766411 422 VPALVAAAATVY 433
Cdd:pfam07690 159 ILSLLAAVLLLL 170
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
78-186 |
6.03e-09 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 57.30 E-value: 6.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:cd17374 54 IFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFF 133
|
90 100
....*....|....*....|....*....
gi 550766411 158 PLGAAGGGAIsSWLIPHhgWRSVLLTGAI 186
Cdd:cd17374 134 SIGQMLLAGL-AYAIRD--WRLLQLVVSV 159
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
78-432 |
6.54e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 57.59 E-value: 6.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:cd17503 50 LSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVI 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 158 PLGAAGGGAISSWLIPHHGWRSV----LLTGAIApliltvllALLLPesvkflvqrgkdVAQVRRIASRFARStldsvtg 233
Cdd:cd17503 130 LLAPAIGPTLGGWLTDNLSWRWIfyinLPIGILA--------LLLAP------------LLDLRLFKDRNFTL------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 234 fflaeekvaskkgsvsqlfsmpwlpGTLMLWVTYFMGLVIYYVLlswmPTLMQ-GMGYALAESAWLTSLFTFGGTAGILL 312
Cdd:cd17503 183 -------------------------GLLLSFLLGLGLFGAMFLL----PLYLQnVLGYSAFESGLVLAPGGLASAILSPL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 313 AGWMMDRWEAHKVVACGFVLTMGLILLLGIEHNH--IALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQG 390
Cdd:cd17503 234 VGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDtsLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNT 313
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 550766411 391 IGRFGGVAGTMTSAQLLSMQWQADSILMILSVPALVAAAATV 432
Cdd:cd17503 314 IRQLGGSIGTALLATLLTNRTQFHHSRLSELLAQQVQKQALI 355
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
43-408 |
2.92e-08 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 55.23 E-value: 2.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 43 MGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLT 122
Cdd:cd17372 18 LSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 123 GLGLGAAmPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWRSVLLTGAIapliltvllalllPES 202
Cdd:cd17372 98 GLGLGGG-PQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSV-------------PSS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 203 VKFLVQRgkdvaqvrriasrfarstldsvtgfflaeekvaskkgsvsqlfsmpWLP-GTLMLWVTYFMGLVIYYVLLSWM 281
Cdd:cd17372 164 LLLVFYR----------------------------------------------WTPkTTLLLWVIWFGNAFAYYGVVLLT 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 282 PTLMQG-------------------MGYALAESAWLTSLF-TFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILLLG 341
Cdd:cd17372 198 TELNNShnvcgsksdsdsgesptekQCRNSNDVDYRDVFIaTFAEFPGLLISAAMIDRLGRKASMASMLFTCCIFLLLLL 277
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550766411 342 IeHNHIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAQLLS 408
Cdd:cd17372 278 I-CQSPFILTVLLFGGRACISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFIAQVLVH 343
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
78-380 |
4.97e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 54.93 E-value: 4.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:cd17328 53 IFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 158 PLGAAGGGAISSWLIPHH-GWRSVLLTGAIAPLILTVLLALLLPEsvkflvqrgkdvaqVRRIASRFARSTLDSVTGFFL 236
Cdd:cd17328 133 PLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVRE--------------PPRGAAEGGVMAKSTATSFLA 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 237 AEEKVASKKgsvSQLFSMpwLPGTLMLWVTYFMGLviyyvllsWMPTLMQGMGYALAESA-----WLTSLFTFGGTAGIL 311
Cdd:cd17328 199 DLKALAKNP---SFILST--LGFTAVSFVTGALAF--------WAPTFFLRAFGVGDLSSadvglIFGAITCIAGVLGVL 265
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550766411 312 LAGWMMDRWEAHKVVACGFVLTMGLIlllgiehnhialfgGLIFLMGIAMNGAQSGMQTLAATFYPTEC 380
Cdd:cd17328 266 LGGILADRLRRKTPRADPLVCAVGLL--------------AAAPFLFLALVLALSNLLLAWVLLFLGEF 320
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
78-186 |
4.99e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 54.50 E-value: 4.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAInTMYCGF 157
Cdd:cd17323 53 IWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAM-GVYSLG 131
|
90 100 110
....*....|....*....|....*....|
gi 550766411 158 P-LGAAGGGAISSWLIPHHGWRSVLLTGAI 186
Cdd:cd17323 132 PlLGPALGPIIGGFITQSLGWRWIFWFLAI 161
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
78-202 |
6.23e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 51.50 E-value: 6.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:TIGR00880 17 LSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGI 96
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 550766411 158 PLGAAGGGAISSWLIPHHGWRSVLLTGAIAPLILTVLLALLLPES 202
Cdd:TIGR00880 97 ALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
48-430 |
9.23e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 53.82 E-value: 9.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 48 PTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLG 127
Cdd:cd17312 27 PPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 128 AAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWRSVLLTGAIapliltvllalllpesVKFLV 207
Cdd:cd17312 107 MGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGI----------------VGLVV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 208 QrgkdvaqvrriasrfarstldSVTGFFLAEEkvaskkgsvsqlfsmPWLpgtlmLWVTYFMGLVIY---YVLLSWMPTL 284
Cdd:cd17312 171 A---------------------IILFFFLRDS---------------PPY-----VWVLSLAYAFVYivrYACLDWGPLY 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 285 MQG-MGYALAESAWLTSLFTFGGTAGILLAGWMMDR-WEAHKVVACGF--VLTMGLILLLGIEHNHIALFGGLIFLMGIA 360
Cdd:cd17312 210 LYEvKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKlFGGRRAPIAVIymLLMTLSLALFWFFPHNKLLSIVLLFLIGFF 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550766411 361 MNGAQSGMQTLAATFYPT-ECRATGIAWMQGIGRFGGVAGTMTSAqLLSMQWQADSILMILSVPALVAAAA 430
Cdd:cd17312 290 VGGPINLIGGAAAQDIGRkEAAGTATGFVGLFGYLGASLAGLPLG-YIIDHYGWSTVFYFLISAALLSVLL 359
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
78-205 |
1.39e-07 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 53.51 E-value: 1.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:cd17362 58 VAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFI 137
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 550766411 158 PLGAAGGGAISSWLIPHHGWRSVLLTGAIAPLILTVLLALLLPESVKF 205
Cdd:cd17362 138 VLGILLGYVSGYAFADVVGGWRYMYGLAAPPALLLGIGMWFLPPSPRW 185
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
80-432 |
1.52e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 52.94 E-value: 1.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 80 GPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAP-QRCRAMAINTMycGFP 158
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGgRRGLAMSIFSV--GGN 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 159 LGAAGGGAISSWLIPHHGWRSVLLTGAIAPLILTVLLALLLPESvkflvqrgkdvaqvrriasrfarstldsvtgfflAE 238
Cdd:cd17478 130 LGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLK----------------------------------KP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 239 EKVASKKGSVSQLFSMPWLPGTLMLWVTYFMGLVIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMD 318
Cdd:cd17478 176 EAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSD 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 319 RWEAHKVVACGFVLTmgLILLLGIEHNHIALFGGLIFLMGIAMNGAQSGMQTLAATFYPtECRATGIAWMQGIGrFGGVA 398
Cdd:cd17478 256 RFGRRRVIIASLLLA--APFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLP-GNVGLASGLMMGLS-FGLGG 331
|
330 340 350
....*....|....*....|....*....|....
gi 550766411 399 GTMTSAQLLSMQWQADSILMILSVPALVAAAATV 432
Cdd:cd17478 332 IGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
85-400 |
1.70e-07 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 53.02 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 85 RMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGG 164
Cdd:cd17327 67 RFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFG 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 165 GAISSWLIPHH------GWRSV-LLTG--AIAPLILTVLLALLLPESVKFLVQRGKDVAqVRRIAsrfARSTLDSVTGFF 235
Cdd:cd17327 147 GLLAYGVFKILgvgglaGWRWLfIIEGliTIIIGLVIFFWLPDNPSKAWFLTEEEKELA-VERLR---ANQTGKGDQKFK 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 236 LAEEKVASKKgsvsqlfsmpwlPGTLMLWVTYFMGLVIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGW 315
Cdd:cd17327 223 WKQIKEAFKD------------PRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAAL 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 316 MMDRWEA---HKVVACGFVLTmGLILLLGIEHNHIALFGGLIFLMGIAmngaqsGMQTLAATFYPTEC-----RATGIAW 387
Cdd:cd17327 291 LSDRFKKrglFAIFACVLALV-GSIILLAAPNPPGAYFAAYILGGGSY------AGFPILLSWISSNCagytkRATVLAI 363
|
330
....*....|...
gi 550766411 388 MQGIGRFGGVAGT 400
Cdd:cd17327 364 MLIFYNVGNIVAP 376
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
27-211 |
3.01e-07 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 52.61 E-value: 3.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 27 VLGFLVLAiDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLGT 106
Cdd:cd17440 3 VLGMALMA-DGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 107 AWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPH------------ 174
Cdd:cd17440 82 SFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHygwsfsmgsayq 161
|
170 180 190
....*....|....*....|....*....|....*...
gi 550766411 175 -HGWRSVLLTGAIaPLILTVLLALLLPESVKFLVQRGK 211
Cdd:cd17440 162 fHSWRVFVIVCAL-PCVSSVVALTFMPESPRFLLEVGK 198
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
78-202 |
5.39e-07 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 51.50 E-value: 5.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAM--AINTMY- 154
Cdd:cd17360 54 IGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRlvTINVLFi 133
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 550766411 155 CGFPLGAAGGGAISSWLipHHGWRSVLLTGAIaPLILTVLLALLLPES 202
Cdd:cd17360 134 TGGQFVAYVINGAFSYL--PGGWRWMLGLAAV-PAVLQFIGLLFLPES 178
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
78-186 |
9.65e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 50.62 E-value: 9.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:cd17370 253 PAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVV 332
|
90 100
....*....|....*....|....*....
gi 550766411 158 PLGAAGGGAISSWLIPHHGWRSVLLTGAI 186
Cdd:cd17370 333 GIGWLLASLIAGYLWDLISPSAAFLFSAV 361
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
80-386 |
1.49e-06 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 49.99 E-value: 1.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 80 GPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLW--------RFLTGLGLGAAMPNAITLISEFAPQRCRAMAIN 151
Cdd:cd17367 61 GRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATIGIWapiilllaRLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSS 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 152 ----TMYCGFPLGAA---------GGGAISSWliphhGWRSVLLTGAIAPliltvllalllpesvkflvqrgkdvaqvrr 218
Cdd:cd17367 141 fqyvTLIGGQLLALGvllvlqhtlGEDQMAAW-----GWRIPFLLGGVLA------------------------------ 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 219 IASRFARSTLDSvTGFFLAEEKVASKKGSVSQLFSMPWLPGTLMLWVTyFMGLVIYYVLLSWMPTLMQG-MGYALAESAW 297
Cdd:cd17367 186 VVVLWLRRGLEE-TESFEAIAESNEASAGTLRELRRHPRELLLVVGLT-AGGTLAFYTWTTYLQKFLVNtAGFSKGDATW 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 298 LTSLFTFGGTAGILLAGWMMDRWEAHKVVAC----GFVLTMGLILLLGIEHNHIALFGgLIFLMGIAMNGAQSGMQTLAA 373
Cdd:cd17367 264 ITTAALLVFMLLQPLGGRLSDRIGRRPLLLFfgigGTLATVPLLSALDHTDSPYTAFA-LVLVGLVFLSGYTSINAVVKA 342
|
330
....*....|...
gi 550766411 374 TFYPTECRATGIA 386
Cdd:cd17367 343 ELFPTHVRALGVG 355
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
78-212 |
2.86e-06 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 49.50 E-value: 2.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAmainTMYCGF 157
Cdd:cd17358 60 LSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRG----ALGSLN 135
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 550766411 158 PLGAAGGGAISSWLIPHHGWRSVLLTGAIAPlILTVLLALLLPESVKFLVQRGKD 212
Cdd:cd17358 136 QLLVNIGILLGYVLGSFLPWRTLALIGAIPP-VVFLILLFFIPESPRWLAKKGRE 189
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
25-182 |
3.38e-06 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 49.34 E-value: 3.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 25 LIVLGFLVLAIDGfdtAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASL 104
Cdd:PRK14995 10 IIVLVYIPVAIDA---TVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 105 GTAWAQSLNTLTLWRFLtgLGLGAAMPNAITLI---SEFAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWRSVL 181
Cdd:PRK14995 87 AAAFSPTASWLIATRAL--LAIGAAMIVPATLAgirATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVF 164
|
.
gi 550766411 182 L 182
Cdd:PRK14995 165 L 165
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
78-422 |
4.16e-06 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 48.53 E-value: 4.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:TIGR00710 59 LWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 158 PLGAAGGGAISSWLIPHHGWRSVLLTGAIAPLILTVLLALLLPESVKflvqrgkdvaQVRRIASRFARSTldsvtgffla 237
Cdd:TIGR00710 139 ALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLP----------YEARIQISTYFET---------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 238 eekvaskkgsvsqlFSMPWLPGTLMLWV-TYFMGLVIYYVLLSWMPTLMQG-MGYALAESAWLTSLFTFGGTAGILLAGW 315
Cdd:TIGR00710 199 --------------FLLLLKSKMFWGYAlIYGASFGGFFAFFSGAPFVYIDiMGVSPSVFGLLFALNIIAMIFGGFLNGR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 316 MMDRWEAHKV----VACGFVLTMGLILLLGIEHNHIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTEC-RATGIAWMQG 390
Cdd:TIGR00710 265 FIKKWGAKSLlrmgLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAgTASALFGTLR 344
|
330 340 350
....*....|....*....|....*....|..
gi 550766411 391 IGrFGGVAGTMTSAQLLSMQWQADSILMILSV 422
Cdd:TIGR00710 345 LV-LGAIVGYLVSLIHGNTAWPMSLSCLVLAV 375
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
78-187 |
4.88e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 48.41 E-value: 4.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISE-FAPQRCRAMAINTMYCG 156
Cdd:cd17476 52 IFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRtYPPGPRKNIVFSLFGAT 131
|
90 100 110
....*....|....*....|....*....|.
gi 550766411 157 FPLGAAGGGAISSWLIPHHGWRSVLLTGAIA 187
Cdd:cd17476 132 APLGFALGGVFGGLFAQLAWWPWIFWFLAIL 162
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
79-431 |
5.21e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 48.32 E-value: 5.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 79 AGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAP--QRCRAMAINTM--Y 154
Cdd:cd17477 51 VPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATneNRGRVLGLYSTvlG 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 155 CGFPLGAAGGGAISSwliphHGWRSVLLTGAIapliltvllalllpesvkflvqrgkdvaqvrriasrFARSTLDSVTGF 234
Cdd:cd17477 131 LGFALGPLLLALVGT-----AGALPFLIAAVL------------------------------------LLLALVPLLLTR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 235 FLAEEKVASKKGSVSQLFSMPWLPGTLMLWVTYFMGlviyyVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAG 314
Cdd:cd17477 170 RAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEG-----AFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 315 WMMDRWEAHKVVACGFVLTMGLILLLGIEHNHIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRF 394
Cdd:cd17477 245 WLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGL 324
|
330 340 350
....*....|....*....|....*....|....*..
gi 550766411 395 GGVAGTMTSAQLLSMqWQADSILMILSVPALVAAAAT 431
Cdd:cd17477 325 GSVIGPLLAGALMDA-FGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
80-186 |
5.47e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 48.41 E-value: 5.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 80 GPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRC--RAMAINTM--YC 155
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVagRIFGYNQSfqYL 340
|
90 100 110
....*....|....*....|....*....|.
gi 550766411 156 GFPLGAAGGGAISSWLiphhGWRSVLLTGAI 186
Cdd:cd17391 341 GNVAGPLLGSAIAAHF----GYRAVFVVTAL 367
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
78-400 |
1.17e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 47.62 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAmPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:cd06179 51 IVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQ-GLGAAVASELVPNKYRGLVQGVVNLVA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 158 PLGAAGGGAISSWLI--PHHGWRSVLLTGAIAPLILTVLLalllpesvkFLVQRGKDVAQVRRIASRFARSTLD------ 229
Cdd:cd06179 130 SPGSALGPLIAGALVeaNAAGWRWIFYINAIFNALALILL---------FFFYHPPPRPQLHGSSTRQKLKRLDwvglfl 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 230 -----------------------------------SVTGFFLAEEKVASKKGSVSQLFSMPWlPGTLMLWVTYFMGLVIY 274
Cdd:cd06179 201 liaglvlfllglswggnpypwssahviaplviggvLLIAFGLYEWKGTKDGLLPPRLLFRGR-NFALILIVAFVEGMIFY 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 275 YVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKV--VACGFVLTMGLILLLGIEHNHIALFGG 352
Cdd:cd06179 280 SLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHIKWqlVAGFVLFTAFLALLALITPDNKALAIA 359
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 550766411 353 LIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGT 400
Cdd:cd06179 360 FSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAVGT 407
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
12-408 |
1.50e-05 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 47.03 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 12 VIDESPFSGFHWLLIVLGFLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGP-----VSDRM 86
Cdd:TIGR00887 4 EADTAPFGWQHFRAIVIAGVGFFTDSYDLFCISLVTKMLGYVYYHGKGPLPSSVSAAVNGSASIGTLAGQlffgwLADKL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 87 GRKRVL---VFSCLFFGLASLGTAWAQSLN---TLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLG 160
Cdd:TIGR00887 84 GRKRVYgmeLIIMIIATVASGLSPGSSPKSvmaTLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAVFAMQGFG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 161 AAGGGAI---------SSWLIPHHG--------------WRSVLLTGAIaPLILTVLLALLLPESVKFLVQRGKDVAQVR 217
Cdd:TIGR00887 164 ILAGAIValivlagfkHSLEAAADEasctgscvpavdymWRILIGFGAV-PALLALYFRLTIPETPRYTADVAKDVEQAA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 218 RIASRF----ARSTLDSVTGfflAEEKVASKKGSVSQLFS--MPWLPGTLMLW--VTYFMGLVIYYVLLSWMPTLMQGMG 289
Cdd:TIGR00887 243 SDMSAVlqvkIEAEPDEVEK---ASTAVEVPKASWSDFFThfFKWRHGKHLLGtaGSWFLLDIAFYGVNLNQKVILSAIG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 290 YALAESAWLTSLFTFGGTAG---ILLAG-----W----MMDRWEAHKVVACGFVLTMGLILLLGIEHNHIALfGGLIFLM 357
Cdd:TIGR00887 320 YSPPAATNNAYEELYKTAVGnliIALAGtvpgyWvtvfLVDIIGRKPIQLMGFFILTVLFFVLGFAYNHLST-HGFLAIY 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 550766411 358 GIAMNGAQSGMQT----LAATFYPTECRATGiawmQGIGRFGGVAGTMTSAQLLS 408
Cdd:TIGR00887 399 VLAQFFANFGPNAttfiVPGEVFPTRYRSTA----HGISAASGKAGAIIGQFGFL 449
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
39-182 |
1.76e-05 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 46.99 E-value: 1.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 39 DTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLW 118
Cdd:TIGR00711 17 DSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIF 96
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550766411 119 RFLTGLGLGAAMPNAITLI-SEFAP-QRCRAMAINTMycGFPLGAAGGGAISSWLIPHHGWRSVLL 182
Cdd:TIGR00711 97 RVIQGFGGGPLIPLSFSTLlNIYPPeKRGRAMAIWGL--TVLVAPALGPTLGGWIIENYHWRWIFL 160
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
78-431 |
1.78e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 46.42 E-value: 1.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:cd17317 44 LFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFW 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 158 PLGAAGGGAIsSWLIPHhgWRSVLLtgAIApliltvllalllpesvkflvqrgkdvaqvrriasrfarstldsvtgffla 237
Cdd:cd17317 124 ALGYMLLALL-AYLIRD--WRWLQL--AIS-------------------------------------------------- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 238 eekvaskkgsvsqlfsmpwLPGTLMLWVTYFMGLVIYYVLLSWMPTLMQGMGYALAESAW----LTSLFTFGGTA--GIL 311
Cdd:cd17317 149 -------------------LPGLLFLLLLWWLPRRTIIVGLIWFVTSLVYYGLSLNSSNLggnlYLNFFLSGLVEipAYF 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 312 LAGWMMDRWEAHKVVACGFVLTMGLILLLGIEHNHIALFGGLIFLMG-IAMNGAQSGMQTLAATFYPTECRATGIAWMQG 390
Cdd:cd17317 210 LALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGkFAISAAFSVIYLYTAELYPTVVRNTGVGLCST 289
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 550766411 391 IGRFGGVAGTMTSaqLLSMQWQADSiLMILSVPALVAAAAT 431
Cdd:cd17317 290 VARVGAILAPFIV--LLGKIGPLLP-LIIFGVLALLGGLLT 327
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
263-388 |
1.78e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.82 E-value: 1.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 263 LWVTYFMGLVIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILLLGI 342
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 550766411 343 EHNHIALFGGLIFLmGIAMNGAQSGMQTLAATFYPTECRATGIAWM 388
Cdd:cd17489 81 ATSVALLLVLRLIH-GIGWGAFTTAAATLVADIIPPSRRGEGIGYY 125
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
78-429 |
1.88e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.45 E-value: 1.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:cd17329 54 IGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAI 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 158 PLGAAGGGAISSWLIpHHGWRSVLLTGAIAPLILTVLLALLLPESVKF-LVQRGKDVAQVRRIASRFARSTLDSVTGFFL 236
Cdd:cd17329 134 NLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLLAALVLLFLLPETRPKrRAAEKTEILRGYKIVLRDRAFLLFLLASFLI 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 237 AeekvaskkgsvsqlfsmpwlpgtlMLWVTYFMGLVIYYVLLswMPTLMQGMGYALAESAWLTSLFTFggtagiLLAGWm 316
Cdd:cd17329 213 S------------------------LIYFQLESTLPVYVVEI--LGLGESLLGLLLALNALLIVLLQF------PVARL- 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 317 MDRWEAHKVVACGFVLtMGLILLLGIEHNHIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGG 396
Cdd:cd17329 260 VERFRLRKILMIGILL-FAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGR 338
|
330 340 350
....*....|....*....|....*....|...
gi 550766411 397 VAGTMTSAQLLSMqWQADSILMILSVPALVAAA 429
Cdd:cd17329 339 AIGPLVGGLLLDL-LGPGLPWLILAALGLIAAA 370
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
78-155 |
2.12e-05 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 46.26 E-value: 2.12e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRA-MAINTMYC 155
Cdd:cd17446 52 VFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAvVGTLLGYC 130
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
79-186 |
2.62e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 46.07 E-value: 2.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 79 AGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLN--TLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCG 156
Cdd:cd17318 76 GGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGygALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSG 155
|
90 100 110
....*....|....*....|....*....|.
gi 550766411 157 FPLGAAGGGAISSWLIPHHGWRSVL-LTGAI 186
Cdd:cd17318 156 SQFGTVIAMPLSGFLCESLGWPSIFyIFGGL 186
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
36-188 |
4.87e-05 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 45.35 E-value: 4.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 36 DGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPV-----SDRMGRKRV------LVFSCLFFGLASL 104
Cdd:cd17364 11 DAYDLFSISLVTKILGRLYYGGKGSLPSGVSGLVNAAALVGTIIGQLffgflGDRFGRKRVygveliIMIIGTILSALSP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 105 GTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYC----GFPLGA-------AGGGAISSWLIP 173
Cdd:cd17364 91 GSTPLGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAmqgfGILAGAivtlilsAIFEHPLPAGTY 170
|
170
....*....|....*...
gi 550766411 174 HH---GWRSVLLTGAIAP 188
Cdd:cd17364 171 HHadlVWRIVLGLGAIPA 188
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
80-183 |
4.94e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 45.27 E-value: 4.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 80 GPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAmpnAIT----LISEFAPQRCRAMAINTMyc 155
Cdd:PRK11043 62 GPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSA---AVIwqalVIDRYPAQKANRVFATIM-- 136
|
90 100 110
....*....|....*....|....*....|.
gi 550766411 156 gfPLGA---AGGGAISSWLIPHHGWRSVLLT 183
Cdd:PRK11043 137 --PLVAlspALAPLLGAWLLNHFGWQAIFAT 165
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
28-436 |
5.69e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.00 E-value: 5.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 28 LGFLVLAIDGfdtAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLGTA 107
Cdd:cd17333 3 ISFFSNGLTD---ALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 108 WAQSLNTLTLWRFLTGLGLGAAMPNAITLISEfAPQRCRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWRSV--LLTGA 185
Cdd:cd17333 80 ATPSIYLFVVLMFLAGLGAGILDTGANTFVGA-LFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWayLIIGL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 186 IAPLILTVLLALLLPESVKFLVQRGKDVAQVRRIASRFarstldsvtgfflaeekvaskkgsvsqlfsmpWLPGTLMLWV 265
Cdd:cd17333 159 IYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLL--------------------------------RNPSIILGAL 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 266 TYFMGLVIYYVLLSWMPT-LMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHK-VVACGFVLTMGLILLLGIE 343
Cdd:cd17333 207 ALFLYVGAETAFSSWVPSyLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTlLVLSGSGALLGLLILLLAP 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 344 HNHIALFGglIFLMGIAMNGAQSGMQTLAATFYPTE-CRATGIAWMQGIgrFGGVAGTMTSAQLLsmqwQADSILMILSV 422
Cdd:cd17333 287 TLVVGLVA--TALLGLFMAALFPTILSLGISNLPYAkGKGTSVLLAAGS--IGGAIIPFIMGFIA----EAVGIQTAMLL 358
|
410
....*....|....
gi 550766411 423 PALVAAAATVYKML 436
Cdd:cd17333 359 ITILYAIIFVLALL 372
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
263-399 |
8.23e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 44.49 E-value: 8.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 263 LWVTYFMGLVIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLtMGLILLLGI 342
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLL-LAVSTLLFA 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 550766411 343 EHNHIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAG 399
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIG 136
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
23-409 |
1.09e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.51 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 23 WLLIVLGFLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSD----RMGRKR-VLVFSCL 97
Cdd:COG2211 10 KEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRpWILIGAI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 98 FFGLASLGTAWAQSLNT------LTLWRFLTGLGLGAAMPNAITLISEFAP---QRCRAMAINTMYCGfpLGAAGGGAIS 168
Cdd:COG2211 90 PLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNIPYSALGAELTPdyeERTRLSSWRFAFAG--LGGLLASVLP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 169 SWLI------PHHGWRSVLLTGAIAPLILTVLLALLLPESVKflvqrgkdvaqvrriasrfarstldsvtgfflAEEKVA 242
Cdd:COG2211 168 PPLVaafggdAALGYRLTALIFAVLGLLAFLLTFFGTKERPV--------------------------------PEEEKV 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 243 SKKGSVSQLFSMPWLpgtLMLWVTYFMGLVIYYVLLSWMPTLMQ-GMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWE 321
Cdd:COG2211 216 SLKESLKALLKNRPF---LLLLLAYLLFFLALALVAALLLYYFKyVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 322 AHKV-VACGFVLTMGLILLLGIEHNHIALFGGLIFLMGIAMNGAQSGMQTLAA-----TFYPTECRATGI--AWMQGIGR 393
Cdd:COG2211 293 KKKAfIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLAdvvdyDEWKTGRRREGLyfGIFTFAIK 372
|
410
....*....|....*.
gi 550766411 394 FGGVAGTMTSAQLLSM 409
Cdd:COG2211 373 LGQALAGALAGLLLAL 388
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
78-430 |
1.09e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.14 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLW-----RFLTGLGLGAAMPNAITLISEFAP--QRCRAMAI 150
Cdd:cd06173 53 FAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWlllvlAFLLGIASAFFGPARQALLPELVPkeQLVRANAL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 151 NTMycGFPLGAAGGGAISSWLIPHHGWRSVLLTGAIAPLILTVLLALLLPESVKFLVQRGKDVAQVRRIASRFARSTLDS 230
Cdd:cd06173 133 NSL--ATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLL 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 231 VTGFFLAeekvaskkgsvsqlfsmpwlpGTLMLWVTYFMGLVIYYVllswmptlMQGMGYALAESAWLTSLFTFGGTAGI 310
Cdd:cd06173 211 RLLLLAL---------------------ALFALLGGALTVLLPLLA--------KEVLGGGAAGYGLLLAAFGVGALLGA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 311 LLAGWMMDRWEAHKVVACGFVLTMGLILLLGIEHNHIALFGGLiFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQG 390
Cdd:cd06173 262 LLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAAL-FLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNA 340
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 550766411 391 IGRFGGVAGTMTSAqLLSMQWQADSILMILSVPALVAAAA 430
Cdd:cd06173 341 LNSGAMPLGALLAG-LLADALGLSAVFLLAGALLLLAALL 379
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
80-376 |
1.34e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 43.75 E-value: 1.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 80 GPVSDRMGRKRVLVFSCLFF-GLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRC-RAMAINTMYcgF 157
Cdd:cd17490 52 GILSDRIGKRKLFIIIGLLFtVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAaKAMGLINLV--N 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 158 PLGAAGGGAISSWLIPHHGWRSVLLTGAIApliltvllalllpesvkflvqrgkdvaqvrriasrfarSTLDSVTGFFLA 237
Cdd:cd17490 130 NLGQLIAFLIGGLIAEHFGMRAPFLLAALA--------------------------------------GVLGFILSLFIK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 238 EEKV--ASKKGSVSQLFSMPWLPgtlMLWVTYFMGLVIYYVLLSWM----PTLMQGMGYALAESAWLTSLFTFGGTAGIL 311
Cdd:cd17490 172 EERRekKPVLTELKELLSVLKDK---KLLFFSLLAILQQMITFSTTfgftPLIAKQLGASSFQLGLLSIIYLLPNALASL 248
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 550766411 312 LAGWMM-DRWEAHKVVACGFVLTMGLILLLGIEHNHIALF---------GGLIF--LMGIAMNGAQSGMQTLAATFY 376
Cdd:cd17490 249 LSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYllqalngfgTGILFplLMSLSIEGVPAEQRSTAMGFF 325
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
76-187 |
1.35e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.76 E-value: 1.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 76 ALIAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQ--RCRAMAINTM 153
Cdd:cd06173 261 ALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDelRGRVFSVYNA 340
|
90 100 110
....*....|....*....|....*....|....*.
gi 550766411 154 --YCGFPLGAAGGGaissWLIPHHGWRSVLLTGAIA 187
Cdd:cd06173 341 lnSGAMPLGALLAG----LLADALGLSAVFLLAGAL 372
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
264-392 |
1.42e-04 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 43.72 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 264 WVTYFMGL--VIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWeAHKVVACGFVLTMGLILLLG 341
Cdd:cd17339 200 QVTLFMGLqsLLFYTLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASLLVPILATRL-KNQRPIVVLLAVLFIIGVLG 278
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 550766411 342 IEHNHIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWM-QGIG 392
Cdd:cd17339 279 LLFAPTALALLWAVLLGLGGGAAFSLALTLISLRSSDPAEAAALSGMaQSVG 330
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
80-185 |
2.41e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 43.37 E-value: 2.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 80 GPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLgLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPL 159
Cdd:PRK09874 75 GGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGL-LGGFVPNANALIATQVPRNKSGWALGTLSTGGVS 153
|
90 100
....*....|....*....|....*.
gi 550766411 160 GAAGGGAISSWLIPHHGWRSVLLTGA 185
Cdd:PRK09874 154 GALLGPLAGGLLADSYGLRPVFFITA 179
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
78-161 |
3.38e-04 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 42.70 E-value: 3.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMA---INTMY 154
Cdd:PRK10473 57 FAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVlslLNGIT 136
|
....*..
gi 550766411 155 CGFPLGA 161
Cdd:PRK10473 137 CIIPVLA 143
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
80-129 |
3.84e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 42.59 E-value: 3.84e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 550766411 80 GPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAA 129
Cdd:PRK11102 47 GPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAA 96
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
262-319 |
4.48e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 42.23 E-value: 4.48e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550766411 262 MLWVTYFMGLVIYYV---LLSWMPT-LMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDR 319
Cdd:cd17345 232 LLWYIAIANVFVYLVrygILDWAPTyLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDK 293
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
26-164 |
4.49e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.02 E-value: 4.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 26 IVLGFLVLAIDGFDTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLASLG 105
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550766411 106 TAWAQSLNTLTLWR---FLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPLGAAGG 164
Cdd:pfam07690 282 LLLLSLTLSSLWLLlalLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
23-363 |
4.87e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.21 E-value: 4.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 23 WLLIVLGFLVLAIDGFdTAAMGYIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMGRKRVLVFSCLFFGLA 102
Cdd:cd17353 3 WLVLLGAVLMHLILGY-QYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 103 SLGTAWAQSLNTLTL-WRFLTGLGLGAAMPNAITLISEFAPQRcRAMAINTMYCGFPLGAAGGGAISSWLIPHHGWRSVL 181
Cdd:cd17353 82 FILSAFAISLPLLFLgYGVLGGIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 182 LTGAIAPLILTVLLALLLPESVKFLVQRGKDVAQVRRIASrfarstldsvTGFFLAEEKVASKKGsvsqlfsmpwlpgtL 261
Cdd:cd17353 161 LILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENS----------PRDYTPREMLRTPTF--------------W 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 262 MLWVTYFMG-LVIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILLL 340
Cdd:cd17353 217 LLWLMFFLNaTAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLL 296
|
330 340
....*....|....*....|...
gi 550766411 341 GIEHNHIALFGGLIFLMGIAMNG 363
Cdd:cd17353 297 PFIGSVAVLFVLGVALIGFCYGG 319
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
78-152 |
8.19e-04 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 41.47 E-value: 8.19e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGL-ASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINT 152
Cdd:cd17356 64 ISSFLSDRIGRKKSIQIGCVIYIIgAIIQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSL 139
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
260-409 |
8.60e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.95 E-value: 8.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 260 TLMLWVTYFMGLVIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILL 339
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 340 LGIEHNhIALFGGLIFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAQLLSM 409
Cdd:COG0477 96 CGLAPS-PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA 164
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
78-129 |
9.70e-04 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 41.43 E-value: 9.70e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAA 129
Cdd:PRK11652 62 FYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVG 113
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
78-183 |
1.42e-03 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 40.80 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRAMAINTMYCGF 157
Cdd:cd17379 52 VIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIVYQMFF 131
|
90 100
....*....|....*....|....*.
gi 550766411 158 PLGAAGGGAIsSWLIPHhgWRSVLLT 183
Cdd:cd17379 132 TLGLLILPGI-AYFIPH--WRWLQLA 154
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
79-202 |
1.48e-03 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 40.85 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 79 AGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMPNAITLISEFAPQRCRA-------MAIN 151
Cdd:cd17437 52 AGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGfltsfpeIFIN 131
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 550766411 152 TmycGFPLGAAGGGAISSwLIPHHGWRSVLLTGAIaPLILTVLLALLLPES 202
Cdd:cd17437 132 I---GILLGYVSNYAFSG-LPLHVGWRLMLGVGAV-PSLFLAIGVLAMPES 177
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
267-428 |
2.75e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.93 E-value: 2.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 267 YFMGLVIYYVLLSWMPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILLLGIEHNh 346
Cdd:cd17393 8 FFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPS- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 347 IALFGGLIFLMGIAMNGAQSGMQTLAATFYptecRATG---IAWMQGIGRFGGVAGTMTSAQLLSMQWQADSILMILSVP 423
Cdd:cd17393 87 VPALALALFLFGAANGALDVAMNAQGVAVE----RAYGrpiMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVL 162
|
....*
gi 550766411 424 ALVAA 428
Cdd:cd17393 163 LLLAA 167
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
261-443 |
2.99e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 39.72 E-value: 2.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 261 LMLWVTYFMGLVIYYVLLswmPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILLL 340
Cdd:cd06174 2 LLGFFLTGLARGLISPLL---PALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 341 GIEHNHIALFGGLiFLMGIAMNGAQSGMQTLAATFYPTECRATGIAWMQGIGRFGGVAGTMTSAQLLSMQWQADSILMIL 420
Cdd:cd06174 79 AFAPSFWLLLLGR-FLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLI 157
|
170 180
....*....|....*....|...
gi 550766411 421 SVPALVAAAATVYKMLYSRSQEP 443
Cdd:cd06174 158 AAALALLAAILLLLVVPDPPESA 180
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
45-187 |
3.08e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 39.63 E-value: 3.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 45 YIAPTLSAEWGIHKQDLGPVLSAALLGLSLGALIAGPVSDRMgRKRVLVFSCLFF-GLASLGTAWAQSLNTLTLWRFLTG 123
Cdd:cd17343 24 FVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQI-SARWLFSSGLVLsGLTTVAFSGSSSVWVFSILWFLNG 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 124 LGLGAAMPN-AITLISEFAPQRcramaINTMY----CGFPLGAAGGGAISSWLIPHHGWRSVL-LTGAIA 187
Cdd:cd17343 103 LAQGLGWPPcAKILRKWFSPSQ-----FGTWWsvlsTSMNLAGSLGPILATLLALSYGWRSTLsISGTVA 167
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
80-185 |
4.94e-03 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 38.88 E-value: 4.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 80 GPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLW--------RFLTGLGLGAAMPNAITLISEFAPQRCRA---- 147
Cdd:cd17366 61 GPLGDKYGRQKVLAITIILMAASTFCIGLLPTYATIGVWapillllaRMVQGFSTGGEYGGAATFVAEYAPDRKRGflgs 140
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 550766411 148 -MAINTmYCGFPLGAAGGGAISSWLIP----HHGWRSVLLTGA 185
Cdd:cd17366 141 wLEFGT-LAGFILGAGLVTLLTLLLTEaqmlDWGWRIPFLIAA 182
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
78-187 |
5.45e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 38.69 E-value: 5.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 78 IAGPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTL-WRFLTGLGLGAAMPNAITLISE-FAPQRCRAMAINTmyC 155
Cdd:cd17352 57 LSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLtYGVLGGLGLGLIYSPAIVIVGQyFEKKRGLATGIAV--A 134
|
90 100 110
....*....|....*....|....*....|...
gi 550766411 156 GFPLGAAGGGAISSWLIPHHGWR-SVLLTGAIA 187
Cdd:cd17352 135 GSGVGTFVFPPLLRYLLDNYGWRgALLILGGLC 167
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
80-150 |
5.54e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 38.74 E-value: 5.54e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550766411 80 GPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLGLGAAMpnAITLISEFAPQ--RCRAMAI 150
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISSV--VMALLADLTREenRTKAMAL 123
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
80-176 |
6.82e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.33 E-value: 6.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 80 GPVSDRMGRKRVLVFSCLFFGLASLGTAWAQSLNTLTLWRFLTGLgLGAAMPNAITLISEFAPQRCRAMAINTMYCGFPL 159
Cdd:cd17330 55 GRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISAAFGL 133
|
90
....*....|....*..
gi 550766411 160 GAAGGGAISSWLIPHHG 176
Cdd:cd17330 134 GFILGPALGGFLSTPYG 150
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
262-320 |
7.11e-03 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 38.54 E-value: 7.11e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550766411 262 MLWVTYFMGLVIY---YVLLSWMPT-LMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRW 320
Cdd:PRK11273 254 LLWYIAIANVFVYllrYGILDWSPTyLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKV 316
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
281-446 |
9.40e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 38.32 E-value: 9.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 281 MPTLMQGMGYALAESAWLTSLFTFGGTAGILLAGWMMDRWEAHKVVACGFVLTMGLILLLGIEHNHIALFGGlIFLMGIA 360
Cdd:COG2807 41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAG-TALIGAG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550766411 361 MNGAQSGMQTLAATFYPTEC-RATGIaWMQGIGRFGGVAGTMTSAQLLSMQWQAdsILMILSVPALVAAAATVYKMLYSR 439
Cdd:COG2807 120 IAVGNVLLPGLIKRWFPDRVgLMTGL-YTAAMGLGAALAAGLTVPLAAALGWRG--ALAVWALLALLALLLWLPLLRRRP 196
|
....*..
gi 550766411 440 SQEPGVA 446
Cdd:COG2807 197 AAAAAAP 203
|
|
| |
