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Conserved domains on  [gi|550794725|ref|WP_022650216|]
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MULTISPECIES: addiction module antidote protein [Enterobacter]

Protein Classification

DNA-binding protein( domain architecture ID 10021416)

DNA-binding protein such as a helix-turn-helix transcriptional regulator, similar to Rhizobium addiction module antitoxin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
dnstrm_HI1420 TIGR02684
probable addiction module antidote protein; Members of this strictly bacterial protein family ...
 3-91 3.84e-41

probable addiction module antidote protein; Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the downstream member of a gene pair. It is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, are located often with prophage regions, but also both in integrated plasmid regions and in housekeeping gene regions. Analysis suggests that the gene pair may serve as an addiction module. [Mobile and extrachromosomal element functions, Other]


:

Pssm-ID: 188241  Cd Length: 89  Bit Score: 130.14  E-value: 3.84e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550794725   3 KLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAVMK 82
Cdd:TIGR02684  1 KLAEFDPAEYLKTEEAIAEYLAQAFEDGDPAYIAHALGYIARARGMTQLAKKTGLSRESLYKALSGKGNPTFDTILKVTK 80


                 ....*....
gi 550794725  83 ALGLGLTIK 91
Cdd:TIGR02684 81 ALGLKLTAK 89
 
Name Accession Description Interval E-value
dnstrm_HI1420 TIGR02684
probable addiction module antidote protein; Members of this strictly bacterial protein family ...
 3-91 3.84e-41

probable addiction module antidote protein; Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the downstream member of a gene pair. It is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, are located often with prophage regions, but also both in integrated plasmid regions and in housekeeping gene regions. Analysis suggests that the gene pair may serve as an addiction module. [Mobile and extrachromosomal element functions, Other]


Pssm-ID: 188241  Cd Length: 89  Bit Score: 130.14  E-value: 3.84e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550794725   3 KLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAVMK 82
Cdd:TIGR02684  1 KLAEFDPAEYLKTEEAIAEYLAQAFEDGDPAYIAHALGYIARARGMTQLAKKTGLSRESLYKALSGKGNPTFDTILKVTK 80


                 ....*....
gi 550794725  83 ALGLGLTIK 91
Cdd:TIGR02684 81 ALGLKLTAK 89
PA5055 COG3636
Uncharacterized Zn-binding protein, DUF971 domain [Mobilome: prophages, transposons];
1-90 1.26e-39

Uncharacterized Zn-binding protein, DUF971 domain [Mobilome: prophages, transposons];


Pssm-ID: 442853  Cd Length: 92  Bit Score: 126.43  E-value: 1.26e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550794725  1 MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV 80
Cdd:COG3636   3 KTKLRDFDLAEYLKDPEDAAAYLNAALEEGDPAELLAALGDVARARGMSQLAKEAGLSRESLYKALSPKGNPTLDTLLKV 82

                        90
                ....*....|
gi 550794725 81 MKALGLGLTI 90
Cdd:COG3636  83 LKALGLRLTV 92
 
Name Accession Description Interval E-value
dnstrm_HI1420 TIGR02684
probable addiction module antidote protein; Members of this strictly bacterial protein family ...
 3-91 3.84e-41

probable addiction module antidote protein; Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the downstream member of a gene pair. It is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, are located often with prophage regions, but also both in integrated plasmid regions and in housekeeping gene regions. Analysis suggests that the gene pair may serve as an addiction module. [Mobile and extrachromosomal element functions, Other]


Pssm-ID: 188241  Cd Length: 89  Bit Score: 130.14  E-value: 3.84e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550794725   3 KLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAVMK 82
Cdd:TIGR02684  1 KLAEFDPAEYLKTEEAIAEYLAQAFEDGDPAYIAHALGYIARARGMTQLAKKTGLSRESLYKALSGKGNPTFDTILKVTK 80


                 ....*....
gi 550794725  83 ALGLGLTIK 91
Cdd:TIGR02684 81 ALGLKLTAK 89
PA5055 COG3636
Uncharacterized Zn-binding protein, DUF971 domain [Mobilome: prophages, transposons];
1-90 1.26e-39

Uncharacterized Zn-binding protein, DUF971 domain [Mobilome: prophages, transposons];


Pssm-ID: 442853  Cd Length: 92  Bit Score: 126.43  E-value: 1.26e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550794725  1 MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV 80
Cdd:COG3636   3 KTKLRDFDLAEYLKDPEDAAAYLNAALEEGDPAELLAALGDVARARGMSQLAKEAGLSRESLYKALSPKGNPTLDTLLKV 82

                        90
                ....*....|
gi 550794725 81 MKALGLGLTI 90
Cdd:COG3636  83 LKALGLRLTV 92
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 21-88 1.99e-03

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 34.23  E-value: 1.99e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550794725 21 VFMADALETGDSAYIAKALGVIARAKGMSTI--SQQTGLSREQLYRSFSDKGNPTLKTTLAVMKALGLGL 88
Cdd:COG3620   4 LMSRDVVTVSPDDTLGEALRLMRKELGLSQLpvAELVGVSQSDILRIESGKRDPTVSTLEKIAEALGKEL 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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