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Conserved domains on  [gi|550795322|ref|WP_022650813|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Enterobacter]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 14398449)

AraC family transcriptional regulator containing a cupin domain as its effector domain and an AraC family helix-turn-helix (HTH) DNA binding domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  2.60.120.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0043565
PubMed:  11282467|33837749|9409145|12270809|19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 19-112 2.01e-26

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


:

Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 98.80  E-value: 2.01e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322  19 VAFRIRVVAQEQFIPLHQHRKGQLIMALGGAITCEVESAMLMVPPQYAVWIPGQTPHSNKATPGAQLCLLFIEPGAL-EL 97
Cdd:cd06124    1 VLARAADYPAGHRTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAAaGL 80

                         90
                 ....*....|....*
gi 550795322  98 PTRTCTLKISPLVRE 112
Cdd:cd06124   81 PAEPCVLAVSPLLRE 95
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
175-254 1.83e-20

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 82.99  E-value: 1.83e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322   175 TLAQWASHFAMSERNLARLVVKETGLSFRRWRHQLQLIVALQFLI-GGKSVQQAAQALGYDSTTAFITMFKKGLGQTPAR 253
Cdd:smart00342   3 TLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRdTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSE 82


                   .
gi 550795322   254 Y 254
Cdd:smart00342  83 Y 83
 
Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 19-112 2.01e-26

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 98.80  E-value: 2.01e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322  19 VAFRIRVVAQEQFIPLHQHRKGQLIMALGGAITCEVESAMLMVPPQYAVWIPGQTPHSNKATPGAQLCLLFIEPGAL-EL 97
Cdd:cd06124    1 VLARAADYPAGHRTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAAaGL 80

                         90
                 ....*....|....*
gi 550795322  98 PTRTCTLKISPLVRE 112
Cdd:cd06124   81 PAEPCVLAVSPLLRE 95
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
175-254 1.83e-20

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 82.99  E-value: 1.83e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322   175 TLAQWASHFAMSERNLARLVVKETGLSFRRWRHQLQLIVALQFLI-GGKSVQQAAQALGYDSTTAFITMFKKGLGQTPAR 253
Cdd:smart00342   3 TLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRdTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSE 82


                   .
gi 550795322   254 Y 254
Cdd:smart00342  83 Y 83
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
13-258 5.96e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 86.37  E-value: 5.96e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322  13 SQHDAAVAFRIRVVAQEQFIPLHQHRKGQLIMALGGAITCEVESAMLMVPPQYAVWIPGQTPHSNKATPGAQLCLLFIEP 92
Cdd:COG2207    8 LLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322  93 GALELPTRTCTLKISPLVRELVLALADRSREELPLPATGRLVDVLFDELPLQPQEHLQLPVSPHPKIRLMSETMANEPAA 172
Cdd:COG2207   88 LLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322 173 WQTLAQWASHFAMSERNLARLVVKETGLSFRRWRHQLQLIVALQFLI-GGKSVQQAAQALGYDSTTAFITMFKKGLGQTP 251
Cdd:COG2207  168 LLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAeTDLSISEIAYELGFSSQSHFSRAFKKRFGVTP 247


                 ....*..
gi 550795322 252 ARYIASL 258
Cdd:COG2207  248 SEYRKRL 254
HTH_18 pfam12833
Helix-turn-helix domain;
179-254 6.25e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 81.48  E-value: 6.25e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550795322  179 WASHFAMSERNLARLVVKETGLSFRRWRHQLQLIVALQFLI--GGKSVQQAAQALGYDSTTAFITMFKKGLGQTPARY 254
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLedTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEY 78
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 144-254 2.00e-14

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 71.73  E-value: 2.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322 144 QPQEHLQLPVSPHPKIRLMSETMANEPAAWQTLAQWASHFAMSERNLARLVVKETGLSFRRWRHQLQLIVALQFLI-GGK 222
Cdd:COG4977  197 QFSPLLVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLEtTDL 276

                         90       100       110
                 ....*....|....*....|....*....|..
gi 550795322 223 SVQQAAQALGYDSTTAFITMFKKGLGQTPARY 254
Cdd:COG4977  277 SIEEIAAACGFGSASHFRRAFRRRFGVSPSAY 308
ftrA PRK09393
transcriptional activator FtrA; Provisional
 144-254 4.25e-07

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 49.96  E-value: 4.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322 144 QPQeHLQLPVSPHPKIRL--MSETMANEPAAWQTLAQWASHFAMSERNLARLVVKETGLSFRRWRHQLQLIVALQFL-IG 220
Cdd:PRK09393 204 QAQ-FVPRPVASRESDRLgpLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLeSS 282

                         90       100       110
                 ....*....|....*....|....*....|....
gi 550795322 221 GKSVQQAAQALGYDSTTAFITMFKKGLGQTPARY 254
Cdd:PRK09393 283 ALSIDQIAERAGFGSEESLRHHFRRRAATSPAAY 316
 
Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 19-112 2.01e-26

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 98.80  E-value: 2.01e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322  19 VAFRIRVVAQEQFIPLHQHRKGQLIMALGGAITCEVESAMLMVPPQYAVWIPGQTPHSNKATPGAQLCLLFIEPGAL-EL 97
Cdd:cd06124    1 VLARAADYPAGHRTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAAaGL 80

                         90
                 ....*....|....*
gi 550795322  98 PTRTCTLKISPLVRE 112
Cdd:cd06124   81 PAEPCVLAVSPLLRE 95
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
175-254 1.83e-20

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 82.99  E-value: 1.83e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322   175 TLAQWASHFAMSERNLARLVVKETGLSFRRWRHQLQLIVALQFLI-GGKSVQQAAQALGYDSTTAFITMFKKGLGQTPAR 253
Cdd:smart00342   3 TLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRdTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSE 82


                   .
gi 550795322   254 Y 254
Cdd:smart00342  83 Y 83
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
13-258 5.96e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 86.37  E-value: 5.96e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322  13 SQHDAAVAFRIRVVAQEQFIPLHQHRKGQLIMALGGAITCEVESAMLMVPPQYAVWIPGQTPHSNKATPGAQLCLLFIEP 92
Cdd:COG2207    8 LLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322  93 GALELPTRTCTLKISPLVRELVLALADRSREELPLPATGRLVDVLFDELPLQPQEHLQLPVSPHPKIRLMSETMANEPAA 172
Cdd:COG2207   88 LLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322 173 WQTLAQWASHFAMSERNLARLVVKETGLSFRRWRHQLQLIVALQFLI-GGKSVQQAAQALGYDSTTAFITMFKKGLGQTP 251
Cdd:COG2207  168 LLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAeTDLSISEIAYELGFSSQSHFSRAFKKRFGVTP 247


                 ....*..
gi 550795322 252 ARYIASL 258
Cdd:COG2207  248 SEYRKRL 254
HTH_18 pfam12833
Helix-turn-helix domain;
179-254 6.25e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 81.48  E-value: 6.25e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550795322  179 WASHFAMSERNLARLVVKETGLSFRRWRHQLQLIVALQFLI--GGKSVQQAAQALGYDSTTAFITMFKKGLGQTPARY 254
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLedTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEY 78
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 144-254 2.00e-14

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 71.73  E-value: 2.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322 144 QPQEHLQLPVSPHPKIRLMSETMANEPAAWQTLAQWASHFAMSERNLARLVVKETGLSFRRWRHQLQLIVALQFLI-GGK 222
Cdd:COG4977  197 QFSPLLVPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLEtTDL 276

                         90       100       110
                 ....*....|....*....|....*....|..
gi 550795322 223 SVQQAAQALGYDSTTAFITMFKKGLGQTPARY 254
Cdd:COG4977  277 SIEEIAAACGFGSASHFRRAFRRRFGVSPSAY 308
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 175-254 5.36e-09

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 55.83  E-value: 5.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322 175 TLAQWASHFAMSERNLARLVVKETGLSFRRWRHQLQLIVALQFLIGGKSVQQAAQALGYDSTTAFITMFKKGLGQTPARY 254
Cdd:COG2169  102 SLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLSVTDAAYAAGFGSLSRFYEAFKKLLGMTPSAY 181
ftrA PRK09393
transcriptional activator FtrA; Provisional
 144-254 4.25e-07

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 49.96  E-value: 4.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322 144 QPQeHLQLPVSPHPKIRL--MSETMANEPAAWQTLAQWASHFAMSERNLARLVVKETGLSFRRWRHQLQLIVALQFL-IG 220
Cdd:PRK09393 204 QAQ-FVPRPVASRESDRLgpLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLeSS 282

                         90       100       110
                 ....*....|....*....|....*....|....
gi 550795322 221 GKSVQQAAQALGYDSTTAFITMFKKGLGQTPARY 254
Cdd:PRK09393 283 ALSIDQIAERAGFGSEESLRHHFRRRAATSPAAY 316
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
13-92 1.03e-05

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 43.30  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322  13 SQHDAAVAFRIRVVAQEQFIPLHQHRKGQLIMALGGAITCEVESAMLMVPPQYAVWIPGQTPHSNKATPGAQLCLLFIEP 92
Cdd:COG1917   17 ADGEDELEVVRVTFEPGARTPWHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFRNLGDEPAVLLVVFS 96
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 166-257 1.56e-05

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 45.37  E-value: 1.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322 166 MANEPAAWQTLAQWASHFAMSERNLARLVVKEtGLSFRRWRHQLQLIVALQFL-IGGKSVQQAAQALGYDSTTAFITMFK 244
Cdd:PRK15185 215 ISSSPSRQWKLTDVADHIFMSTSTLKRKLAEE-GTSFSDIYLSARMNQAAKLLrIGNHNVNAVALKCGYDSTSYFIQCFK 293

                         90
                 ....*....|...
gi 550795322 245 KGLGQTPARYIAS 257
Cdd:PRK15185 294 KYFKTTPSTFIKM 306
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 156-254 1.60e-05

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 45.30  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322 156 HPKIRLMSETMANEPAA--WqTLAQWASHFAMSErNLARLVVKETGLSFRRWRHQLQLIVALQFL-IGGKSVQQAAQALG 232
Cdd:PRK09978 140 QPNMRTRVCTVINNNIAheW-TLARIASELLMSP-SLLKKKLREEETSYSQLLTECRMQRALQLIvIHGFSIKRVAVSCG 217

                         90       100
                 ....*....|....*....|..
gi 550795322 233 YDSTTAFITMFKKGLGQTPARY 254
Cdd:PRK09978 218 YHSVSYFIYVFRNYYGMTPTEY 239
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
109-263 2.22e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 44.90  E-value: 2.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322 109 LVRELVLALADRSREELPLpaTGRLVDVLFDELPLQPQEH-------LQLPVSPhpKIRLMSETMANEPAAWQTLAQWAS 181
Cdd:PRK13501 125 QARPIIQQLAQESRKTDSW--SIQLTEVLLLQLAIVLKRHryraeqaHLLPDGE--QLDLIMSALQQSLGAYFDMADFCH 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322 182 HFAMSERNLARLVVKETGLSFRRWRHQLQLIVALQFLIGGKS-VQQAAQALGYDSTTAFITMFKKGLGQTPA----RYIA 256
Cdd:PRK13501 201 KNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHrISDIAARCGFEDSNYFSAVFTREAGMTPRdyrqRFIR 280


                 ....*..
gi 550795322 257 SLTTTSR 263
Cdd:PRK13501 281 SPVLPAK 287
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
152-254 4.18e-04

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 40.73  E-value: 4.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322 152 PVSPHPKI--------RLMSETMANEpaawQTLAQWASHFAMSERNLARLVVKETGLSFRRWRHQLQLIVA---LQFliG 220
Cdd:PRK10572 174 PESLHPPMdprvreacQYISDHLASE----FDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAkllLQT--T 247

                         90       100       110
                 ....*....|....*....|....*....|....
gi 550795322 221 GKSVQQAAQALGYDSTTAFITMFKKGLGQTPARY 254
Cdd:PRK10572 248 RMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEF 281
cupin_YobQ-like_N cd07003
Bacillus subtilis YobQ and related proteins, N-terminal cupin domain; This family includes ...
 35-87 2.33e-03

Bacillus subtilis YobQ and related proteins, N-terminal cupin domain; This family includes bacterial proteins homologous to Bacillus subtilis YobQ and Photobacterium leiognathi LumQ, both uncharacterized proteins thought to be DNA-binding proteins that may function as AraC/XylS family transcriptional regulators. YobQ has an N-terminal cupin beta barrel domain (represented by this alignment model) and a C-terminal AraC/XylS family helix-turn-helix (HTH) DNA-binding domain. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380407 [Multi-domain]  Cd Length: 66  Bit Score: 35.83  E-value: 2.33e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 550795322  35 HQHRKGQLIMALGGAITCEVESAMLMVPPQYAVWIPGQTPHSNkATPGAQLCL 87
Cdd:cd07003   10 HSHEHAQLVLPLSGSLELEVEGRGSRVKPDIGLYIPPNAEHRF-AGSSDNRCL 61
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
9-94 4.35e-03

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 36.27  E-value: 4.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550795322   9 YDPDSQHDAAVAFRIRVVAQEQFIPLHQHRKG-QLIMALGGAITCEVESAMLMVPPQYAVWIPGQTPHSNKATPGAQLCL 87
Cdd:COG0662   17 YEVLGEGGERLSVKRITVPPGAELSLHVHPHRdEFFYVLEGTGEVTIGDEEVELKAGDSVYIPAGVPHRLRNPGDEPLEL 96


                 ....*..
gi 550795322  88 LFIEPGA 94
Cdd:COG0662   97 LEVQAPA 103
cupin_BacB_N cd20307
Bacillus subtilis bacilysin and related proteins, N-terminal cupin domain; This model ...
 21-76 7.21e-03

Bacillus subtilis bacilysin and related proteins, N-terminal cupin domain; This model represents the N-terminal domain of bacilysin (BacB, also known as AerE in Microcystis aeruginosa), a non-ribosomally synthesized dipeptide antibiotic that is produced and excreted by certain strains of Bacillus subtilis. Bacilysin is an oxidase that catalyzes the synthesis of 2-oxo-3-(4-oxocyclohexa-2,5-dienyl)propanoic acid, a precursor to L-anticapsin. Each bacilysin monomer has two tandem cupin domains. It is active against a wide range of bacteria and some fungi. The antimicrobial activity of bacilysin is antagonized by glucosamine and N-acetyl glucosamine, indicating that bacilysin interferes with glucosamine synthesis, and thus, with the synthesis of microbial cell walls. AerE is thought to be involved in the formation of the 2-carboxy-6-hydroxyoctahydroindole (Choi) moiety found on all aeruginosin tetrapeptides, based on gene knock-out experiments. It is encoded by the aerE gene of the aerABCDEF Aeruginosin biosynthesis gene cluster in Microcystis aeruginosa. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380441 [Multi-domain]  Cd Length: 100  Bit Score: 35.32  E-value: 7.21e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 550795322  21 FRIRVVAQEQFIPLHQHRKGQLIMALGGAITCEV-ESAMLMVPPQYAVWIPGQTPHS 76
Cdd:cd20307   26 VQLSYIAPGAVVELHQHPESQIGMVLSGELEMNVgGVKKVMEPLQDVYVAPPNVPHG 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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