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Conserved domains on  [gi|552479603|ref|WP_022991796|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Marinobacter]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
19-170 1.67e-17

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 76.09  E-value: 1.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552479603  19 RIRNRHAILRAARDCFQEHGYDNTTIRDIVRRTGLAAGTFYNYFSSKQDIFAALLSDFLTSLNNDMsQQRQSASSTQEFV 98
Cdd:COG1309    4 REATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAAL-EEALAAEDPRERL 82
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 552479603  99 YRAYLALYSATAKDPVVYELAHQNQRALRNLfGSDILGLTMLSLEEDVRNAMTRGLLPAVDADYLCAAFFGV 170
Cdd:COG1309   83 RALLRAYLEFLAENPALARLLLAEAAELPEL-RAALRALLRRLRALLAELLRAGGLLADVDPDALARALLAL 153
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
19-170 1.67e-17

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 76.09  E-value: 1.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552479603  19 RIRNRHAILRAARDCFQEHGYDNTTIRDIVRRTGLAAGTFYNYFSSKQDIFAALLSDFLTSLNNDMsQQRQSASSTQEFV 98
Cdd:COG1309    4 REATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAAL-EEALAAEDPRERL 82
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 552479603  99 YRAYLALYSATAKDPVVYELAHQNQRALRNLfGSDILGLTMLSLEEDVRNAMTRGLLPAVDADYLCAAFFGV 170
Cdd:COG1309   83 RALLRAYLEFLAENPALARLLLAEAAELPEL-RAALRALLRRLRALLAELLRAGGLLADVDPDALARALLAL 153
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
26-72 4.90e-15

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 66.28  E-value: 4.90e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 552479603   26 ILRAARDCFQEHGYDNTTIRDIVRRTGLAAGTFYNYFSSKQDIFAAL 72
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
20-170 1.09e-12

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 64.15  E-value: 1.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552479603  20 IRNRHAILRAARDCFQEHGYDNTTIRDIVRRTGLAAGTFYNYFSSKQDIFAALLSDFLTSLNNDMSQQRQS-ASSTQEFV 98
Cdd:NF041196   5 IRTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAVEPQRAGgGSKLQELV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552479603  99 yRAYLALYSATAKDPVV---YELAHQNQRALRNLFG-----SDIlgltmlsLEEDVRNAMTRG-LLPAVD----ADYLCA 165
Cdd:NF041196  85 -DLTHVLARRLRTDPVVragVRLSIEQAAIGAGLPTpyrewIDL-------VAELLAEARAAGeLLPGVDpeeaARLLVG 156

                 ....*
gi 552479603 166 AFFGV 170
Cdd:NF041196 157 AFTGV 161
PRK00767 PRK00767
transcriptional regulator BetI; Validated
20-129 1.65e-06

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 46.76  E-value: 1.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552479603  20 IRnRHAILRAARDCFQEHGYDNTTIRDIVRRTGLAAGTFYNYFSSKQDIFAALLSDFLTSLNNDMSQQRQSASSTQE--- 96
Cdd:PRK00767   9 IR-RQQLIDATLRAIGEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLEATMRHLLRQLGDAVLARLAAAADTPRarl 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 552479603  97 -------F--------VYRAYLALYSATAKDPVVYELAHQNQRALR-NL 129
Cdd:PRK00767  88 raiveanFdasqfsspAMKTWLAFWASSMHSPDLRRLQRINSRRLYsNL 136
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
23-77 8.79e-04

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 39.05  E-value: 8.79e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 552479603  23 RHAILRAARDCFQEHGYDNTTIRDIVRRTGL-AAGTFYnYFSSKQDIFAALLSDFL 77
Cdd:NF037937   1 KEKILDAAISLFNTKGFDGTSVRDIAKKAKVnVALISY-YFKGKQGLLEYLVTSFF 55
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
19-170 1.67e-17

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 76.09  E-value: 1.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552479603  19 RIRNRHAILRAARDCFQEHGYDNTTIRDIVRRTGLAAGTFYNYFSSKQDIFAALLSDFLTSLNNDMsQQRQSASSTQEFV 98
Cdd:COG1309    4 REATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAAL-EEALAAEDPRERL 82
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 552479603  99 YRAYLALYSATAKDPVVYELAHQNQRALRNLfGSDILGLTMLSLEEDVRNAMTRGLLPAVDADYLCAAFFGV 170
Cdd:COG1309   83 RALLRAYLEFLAENPALARLLLAEAAELPEL-RAALRALLRRLRALLAELLRAGGLLADVDPDALARALLAL 153
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
26-72 4.90e-15

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 66.28  E-value: 4.90e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 552479603   26 ILRAARDCFQEHGYDNTTIRDIVRRTGLAAGTFYNYFSSKQDIFAAL 72
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
20-170 1.09e-12

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 64.15  E-value: 1.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552479603  20 IRNRHAILRAARDCFQEHGYDNTTIRDIVRRTGLAAGTFYNYFSSKQDIFAALLSDFLTSLNNDMSQQRQS-ASSTQEFV 98
Cdd:NF041196   5 IRTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEEQVARLREAVEPQRAGgGSKLQELV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552479603  99 yRAYLALYSATAKDPVV---YELAHQNQRALRNLFG-----SDIlgltmlsLEEDVRNAMTRG-LLPAVD----ADYLCA 165
Cdd:NF041196  85 -DLTHVLARRLRTDPVVragVRLSIEQAAIGAGLPTpyrewIDL-------VAELLAEARAAGeLLPGVDpeeaARLLVG 156

                 ....*
gi 552479603 166 AFFGV 170
Cdd:NF041196 157 AFTGV 161
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
23-155 1.25e-07

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 49.94  E-value: 1.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552479603  23 RHAILRAARDCFQEHGYDNTTIRDIVRRTGLAAGTFYNYFSSKQDIFAALLSDFLTSLNNDMSQQRQSASSTQEFV---- 98
Cdd:COG3226   10 RERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDAAeala 89
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 552479603  99 -------------YRAYLALYSATAKDPVVYELAHQNQRALRNLFGSDILGLTMLSLEEDVRN--AMTRGLL 155
Cdd:COG3226   90 dllaellpadrdrLLARYELYLEALRDPELRALLRRWRDRLREALARLLAALGSPDPPETARAlvALIDGLT 161
PRK00767 PRK00767
transcriptional regulator BetI; Validated
20-129 1.65e-06

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 46.76  E-value: 1.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552479603  20 IRnRHAILRAARDCFQEHGYDNTTIRDIVRRTGLAAGTFYNYFSSKQDIFAALLSDFLTSLNNDMSQQRQSASSTQE--- 96
Cdd:PRK00767   9 IR-RQQLIDATLRAIGEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLEATMRHLLRQLGDAVLARLAAAADTPRarl 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 552479603  97 -------F--------VYRAYLALYSATAKDPVVYELAHQNQRALR-NL 129
Cdd:PRK00767  88 raiveanFdasqfsspAMKTWLAFWASSMHSPDLRRLQRINSRRLYsNL 136
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
10-77 7.99e-05

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 42.22  E-value: 7.99e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 552479603  10 QATGKRALNRIRNRHAILRAARDCFQEHGYDNTTIRDIVRRTGLAAGTFYNYFSSKQDIFAALLSDFL 77
Cdd:PRK15008   7 KTTGKRSRAVSAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQIL 74
PRK14996 PRK14996
TetR family transcriptional regulator; Provisional
17-95 6.68e-04

TetR family transcriptional regulator; Provisional


Pssm-ID: 184958 [Multi-domain]  Cd Length: 192  Bit Score: 39.31  E-value: 6.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552479603  17 LNRIRNRHAILRAARDCFQEHGYDNTTIRDIVRRTGLAAGTFYNYFSS----KQDIFAALLSDFLtslnnDMSQQRQSAS 92
Cdd:PRK14996   4 LNRDERREVILQAAMRVALAEGFAAMTVRRIASEAQVAAGQVHHHFSSagelKALAFIHLIRQLL-----DAEQVPQTAS 78

                 ...
gi 552479603  93 STQ 95
Cdd:PRK14996  79 WRE 81
septum_RefZ NF037937
forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in ...
23-77 8.79e-04

forespore capture DNA-binding protein RefZ; RefZ (regulator of FtsZ), a DNA-binding protein in the family of TetR/AcrR family transcriptional regulators, participates in septum placement and in chromosome capture during the asymmetrical cell division in endospore formation. The five nearly palindromic DNA motifs (RBMs) to which RefZ binds affect chromosomal localization, not transcription, so RefZ is not considered a transcription factor.


Pssm-ID: 468281 [Multi-domain]  Cd Length: 195  Bit Score: 39.05  E-value: 8.79e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 552479603  23 RHAILRAARDCFQEHGYDNTTIRDIVRRTGL-AAGTFYnYFSSKQDIFAALLSDFL 77
Cdd:NF037937   1 KEKILDAAISLFNTKGFDGTSVRDIAKKAKVnVALISY-YFKGKQGLLEYLVTSFF 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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