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Conserved domains on  [gi|552765385|ref|WP_023017512|]
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MULTISPECIES: NAD(P)/FAD-dependent oxidoreductase [Corynebacterium]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 11441299)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to sulfide:quinone oxidoreductase which catalyzes the oxidation of hydrogen sulfide using quinone as the electron acceptor

EC:  1.6.-.-
Gene Ontology:  GO:0003954|GO:0006116
PubMed:  15590775|28181562

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
25-415 3.53e-136

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


:

Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 396.43  E-value: 3.53e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  25 LNTVKKLKN---ADVEITLIDKKNHHLFQPMLYQVATGMISAGEVAPSTRQLLRNQdNVDFVNGNVTDINLEDQTVTaeL 101
Cdd:COG1252   14 LEAARRLRKklgGDAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRRA-GVRFIQGEVTGIDPEARTVT--L 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 102 DDfSRTYSYDSLVVAAGSSQSYFGNDHFAKFAPGMKTLDDALELRSRIISAFEKaeltddpAERERLLTFIIVGAGPTGV 181
Cdd:COG1252   91 AD-GRTLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFER-------AERRRLLTIVVVGGGPTGV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 182 ELTGQIAELANRTLSdvYSTYGTSAAKIYLLDGAPQVLPPFGKRLGRRAQRTLEKEGVNVRLNAMVTDVNEDSVTYKNmk 261
Cdd:COG1252  163 ELAGELAELLRKLLR--YPGIDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADGVTLED-- 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 262 tdeEVTLEGATKIWSAGVAASPLGKmvadQAGVEADRAGRVSVNDDMTVGDFNNVYIIGDMMSL-----NRLPGLAQVAI 336
Cdd:COG1252  239 ---GEEIPADTVIWAAGVKAPPLLA----DLGLPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVpdpdgKPVPKTAQAAV 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 552765385 337 QGGEHVAKLIETKVDEEstadEKEPFEYFDKGSMAIVTRFNAVVKLGKTEFSGFPGWLAWLALHLTYVIGLRSRLAVLV 415
Cdd:COG1252  312 QQAKVLAKNIAALLRGK----PLKPFRYRDKGCLASLGRGAAVADVGGLKLSGFLAWLLKRAIHLYFLPGFRGRLRVLL 386
 
Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
25-415 3.53e-136

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 396.43  E-value: 3.53e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  25 LNTVKKLKN---ADVEITLIDKKNHHLFQPMLYQVATGMISAGEVAPSTRQLLRNQdNVDFVNGNVTDINLEDQTVTaeL 101
Cdd:COG1252   14 LEAARRLRKklgGDAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRRA-GVRFIQGEVTGIDPEARTVT--L 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 102 DDfSRTYSYDSLVVAAGSSQSYFGNDHFAKFAPGMKTLDDALELRSRIISAFEKaeltddpAERERLLTFIIVGAGPTGV 181
Cdd:COG1252   91 AD-GRTLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFER-------AERRRLLTIVVVGGGPTGV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 182 ELTGQIAELANRTLSdvYSTYGTSAAKIYLLDGAPQVLPPFGKRLGRRAQRTLEKEGVNVRLNAMVTDVNEDSVTYKNmk 261
Cdd:COG1252  163 ELAGELAELLRKLLR--YPGIDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADGVTLED-- 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 262 tdeEVTLEGATKIWSAGVAASPLGKmvadQAGVEADRAGRVSVNDDMTVGDFNNVYIIGDMMSL-----NRLPGLAQVAI 336
Cdd:COG1252  239 ---GEEIPADTVIWAAGVKAPPLLA----DLGLPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVpdpdgKPVPKTAQAAV 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 552765385 337 QGGEHVAKLIETKVDEEstadEKEPFEYFDKGSMAIVTRFNAVVKLGKTEFSGFPGWLAWLALHLTYVIGLRSRLAVLV 415
Cdd:COG1252  312 QQAKVLAKNIAALLRGK----PLKPFRYRDKGCLASLGRGAAVADVGGLKLSGFLAWLLKRAIHLYFLPGFRGRLRVLL 386
PTZ00318 PTZ00318
NADH dehydrogenase-like protein; Provisional
 28-418 1.22e-72

NADH dehydrogenase-like protein; Provisional


Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 235.05  E-value: 1.22e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  28 VKKLKNADVEITLIDKKNHHLFQPMLYQVATGMISAGEVAPSTRQLLRNQDNvDFVNGNVTDINLEDQTVTAELDDFSR- 106
Cdd:PTZ00318  26 VRNLDPKKYNITVISPRNHMLFTPLLPQTTTGTLEFRSICEPVRPALAKLPN-RYLRAVVYDVDFEEKRVKCGVVSKSNn 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 107 ------TYSYDSLVVAAGSSQSYFGNDHFAKFAPGMKTLDDALELRSRIISAFEKAELTD-DPAERERLLTFIIVGAGPT 179
Cdd:PTZ00318 105 anvntfSVPYDKLVVAHGARPNTFNIPGVEERAFFLKEVNHARGIRKRIVQCIERASLPTtSVEERKRLLHFVVVGGGPT 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 180 GVELTGQIAELANRTLSDVYsTYGTSAAKIYLLDGAPQVLPPFGKRLGRRAQRTLEKEGVNVRLNAMVTDVNEDSVTYKn 259
Cdd:PTZ00318 185 GVEFAAELADFFRDDVRNLN-PELVEECKVTVLEAGSEVLGSFDQALRKYGQRRLRRLGVDIRTKTAVKEVLDKEVVLK- 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 260 mktDEEVtLEGATKIWSAGVAASPLGKmvadQAGVEADRAGRVSVNDDMTVGDFNNVYIIGDMMSLNR--LPGLAQVAIQ 337
Cdd:PTZ00318 263 ---DGEV-IPTGLVVWSTGVGPGPLTK----QLKVDKTSRGRISVDDHLRVKPIPNVFALGDCAANEErpLPTLAQVASQ 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 338 GGEHVAKLIEtkvDEESTADEKEPFEYFDKGSMAIVTRFNAVVKLGKTEFSGFPGWLAWLALHLTYVIGLRSRLAVLVNW 417
Cdd:PTZ00318 335 QGVYLAKEFN---NELKGKPMSKPFVYRSLGSLAYLGNYSAIVQLGAFDLSGFKALLFWRSAYLTILGSWRSKLYVLVNW 411


                 .
gi 552765385 418 A 418
Cdd:PTZ00318 412 A 412
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 25-339 1.21e-41

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 149.78  E-value: 1.21e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385   25 LNTVKKLKNADVEITLI-DKKNHHLFQPMLYQVATGMISAGEVAPSTRQLLRNQDNVDF---------VNGNVTDINLED 94
Cdd:pfam07992  13 LAAALTLAQLGGKVTLIeDEGTCPYGGCVLSKALLGAAEAPEIASLWADLYKRKEEVVKklnngievlLGTEVVSIDPGA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385   95 QTVTAE--LDDFSRTYSYDSLVVAAGSSQSYF---GNDHFAKFapGMKTLDDALELRSRIIsafekaeltddpaeRERLL 169
Cdd:pfam07992  93 KKVVLEelVDGDGETITYDRLVIATGARPRLPpipGVELNVGF--LVRTLDSAEALRLKLL--------------PKRVV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  170 tfiIVGAGPTGVELTGQIAELAnrtlsdvystygtsaAKIYLLDGAPQVLPPFGKRLGRRAQRTLEKEGVNVRLNAMVTD 249
Cdd:pfam07992 157 ---VVGGGYIGVELAAALAKLG---------------KEVTLIEALDRLLRAFDEEISAALEKALEKNGVEVRLGTSVKE 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  250 VNEDSVTYKnMKTDEEVTLEGATKIWSAGVAASPLGkmvADQAGVEADRAGRVSVNDDMTVGDfNNVYIIGDMMSlnRLP 329
Cdd:pfam07992 219 IIGDGDGVE-VILKDGTEIDADLVVVAIGRRPNTEL---LEAAGLELDERGGIVVDEYLRTSV-PGIYAAGDCRV--GGP 291

                         330
                  ....*....|
gi 552765385  330 GLAQVAIQGG 339
Cdd:pfam07992 292 ELAQNAVAQG 301
 
Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
25-415 3.53e-136

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 396.43  E-value: 3.53e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  25 LNTVKKLKN---ADVEITLIDKKNHHLFQPMLYQVATGMISAGEVAPSTRQLLRNQdNVDFVNGNVTDINLEDQTVTaeL 101
Cdd:COG1252   14 LEAARRLRKklgGDAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRRA-GVRFIQGEVTGIDPEARTVT--L 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 102 DDfSRTYSYDSLVVAAGSSQSYFGNDHFAKFAPGMKTLDDALELRSRIISAFEKaeltddpAERERLLTFIIVGAGPTGV 181
Cdd:COG1252   91 AD-GRTLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFER-------AERRRLLTIVVVGGGPTGV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 182 ELTGQIAELANRTLSdvYSTYGTSAAKIYLLDGAPQVLPPFGKRLGRRAQRTLEKEGVNVRLNAMVTDVNEDSVTYKNmk 261
Cdd:COG1252  163 ELAGELAELLRKLLR--YPGIDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADGVTLED-- 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 262 tdeEVTLEGATKIWSAGVAASPLGKmvadQAGVEADRAGRVSVNDDMTVGDFNNVYIIGDMMSL-----NRLPGLAQVAI 336
Cdd:COG1252  239 ---GEEIPADTVIWAAGVKAPPLLA----DLGLPTDRRGRVLVDPTLQVPGHPNVFAIGDCAAVpdpdgKPVPKTAQAAV 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 552765385 337 QGGEHVAKLIETKVDEEstadEKEPFEYFDKGSMAIVTRFNAVVKLGKTEFSGFPGWLAWLALHLTYVIGLRSRLAVLV 415
Cdd:COG1252  312 QQAKVLAKNIAALLRGK----PLKPFRYRDKGCLASLGRGAAVADVGGLKLSGFLAWLLKRAIHLYFLPGFRGRLRVLL 386
PTZ00318 PTZ00318
NADH dehydrogenase-like protein; Provisional
 28-418 1.22e-72

NADH dehydrogenase-like protein; Provisional


Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 235.05  E-value: 1.22e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  28 VKKLKNADVEITLIDKKNHHLFQPMLYQVATGMISAGEVAPSTRQLLRNQDNvDFVNGNVTDINLEDQTVTAELDDFSR- 106
Cdd:PTZ00318  26 VRNLDPKKYNITVISPRNHMLFTPLLPQTTTGTLEFRSICEPVRPALAKLPN-RYLRAVVYDVDFEEKRVKCGVVSKSNn 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 107 ------TYSYDSLVVAAGSSQSYFGNDHFAKFAPGMKTLDDALELRSRIISAFEKAELTD-DPAERERLLTFIIVGAGPT 179
Cdd:PTZ00318 105 anvntfSVPYDKLVVAHGARPNTFNIPGVEERAFFLKEVNHARGIRKRIVQCIERASLPTtSVEERKRLLHFVVVGGGPT 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 180 GVELTGQIAELANRTLSDVYsTYGTSAAKIYLLDGAPQVLPPFGKRLGRRAQRTLEKEGVNVRLNAMVTDVNEDSVTYKn 259
Cdd:PTZ00318 185 GVEFAAELADFFRDDVRNLN-PELVEECKVTVLEAGSEVLGSFDQALRKYGQRRLRRLGVDIRTKTAVKEVLDKEVVLK- 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 260 mktDEEVtLEGATKIWSAGVAASPLGKmvadQAGVEADRAGRVSVNDDMTVGDFNNVYIIGDMMSLNR--LPGLAQVAIQ 337
Cdd:PTZ00318 263 ---DGEV-IPTGLVVWSTGVGPGPLTK----QLKVDKTSRGRISVDDHLRVKPIPNVFALGDCAANEErpLPTLAQVASQ 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 338 GGEHVAKLIEtkvDEESTADEKEPFEYFDKGSMAIVTRFNAVVKLGKTEFSGFPGWLAWLALHLTYVIGLRSRLAVLVNW 417
Cdd:PTZ00318 335 QGVYLAKEFN---NELKGKPMSKPFVYRSLGSLAYLGNYSAIVQLGAFDLSGFKALLFWRSAYLTILGSWRSKLYVLVNW 411


                 .
gi 552765385 418 A 418
Cdd:PTZ00318 412 A 412
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 25-339 1.21e-41

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 149.78  E-value: 1.21e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385   25 LNTVKKLKNADVEITLI-DKKNHHLFQPMLYQVATGMISAGEVAPSTRQLLRNQDNVDF---------VNGNVTDINLED 94
Cdd:pfam07992  13 LAAALTLAQLGGKVTLIeDEGTCPYGGCVLSKALLGAAEAPEIASLWADLYKRKEEVVKklnngievlLGTEVVSIDPGA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385   95 QTVTAE--LDDFSRTYSYDSLVVAAGSSQSYF---GNDHFAKFapGMKTLDDALELRSRIIsafekaeltddpaeRERLL 169
Cdd:pfam07992  93 KKVVLEelVDGDGETITYDRLVIATGARPRLPpipGVELNVGF--LVRTLDSAEALRLKLL--------------PKRVV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  170 tfiIVGAGPTGVELTGQIAELAnrtlsdvystygtsaAKIYLLDGAPQVLPPFGKRLGRRAQRTLEKEGVNVRLNAMVTD 249
Cdd:pfam07992 157 ---VVGGGYIGVELAAALAKLG---------------KEVTLIEALDRLLRAFDEEISAALEKALEKNGVEVRLGTSVKE 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  250 VNEDSVTYKnMKTDEEVTLEGATKIWSAGVAASPLGkmvADQAGVEADRAGRVSVNDDMTVGDfNNVYIIGDMMSlnRLP 329
Cdd:pfam07992 219 IIGDGDGVE-VILKDGTEIDADLVVVAIGRRPNTEL---LEAAGLELDERGGIVVDEYLRTSV-PGIYAAGDCRV--GGP 291

                         330
                  ....*....|
gi 552765385  330 GLAQVAIQGG 339
Cdd:pfam07992 292 ELAQNAVAQG 301
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 32-346 1.03e-27

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 112.21  E-value: 1.03e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  32 KNADVEITLIDKKNHHLFQP--MLYQVATGMISAGEVAPSTRQLLRnQDNVDFVNGN-VTDINLEDQTVTaeLDDfSRTY 108
Cdd:COG0446    2 LGPDAEITVIEKGPHHSYQPcgLPYYVGGGIKDPEDLLVRTPESFE-RKGIDVRTGTeVTAIDPEAKTVT--LRD-GETL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 109 SYDSLVVAAGSSQSYF---GNDHfakfaPG---MKTLDDALELRsriisafekAELTDDPAERerlltFIIVGAGPTGVE 182
Cdd:COG0446   78 SYDKLVLATGARPRPPpipGLDL-----PGvftLRTLDDADALR---------EALKEFKGKR-----AVVIGGGPIGLE 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 183 LtgqiAE-LANRtlsdvystyGtsaAKIYLLDGAPQVLPPFGKRLGRRAQRTLEKEGVNVRLNAMVTDVNEDSVTyknmk 261
Cdd:COG0446  139 L----AEaLRKR---------G---LKVTLVERAPRLLGVLDPEMAALLEEELREHGVELRLGETVVAIDGDDKV----- 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 262 tdeEVTLEGATK------IWSAGVAASPlgkMVADQAGVEADRAGRVSVNDDMTVGDfNNVYIIGDMMSLN--------R 327
Cdd:COG0446  198 ---AVTLTDGEEipadlvVVAPGVRPNT---ELAKDAGLALGERGWIKVDETLQTSD-PDVYAAGDCAEVPhpvtgktvY 270

                        330
                 ....*....|....*....
gi 552765385 328 LPgLAQVAIQGGEHVAKLI 346
Cdd:COG0446  271 IP-LASAANKQGRVAAENI 288
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 71-346 2.16e-18

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 87.06  E-value: 2.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  71 RQLLRNqDNVDFVNGNVTdinLEDQTvTAELDDfSRTYSYDSLVVAAGSSQSY---FGNDHfakfaPGMKTLDDALELRs 147
Cdd:COG1249   98 EELLKK-NGVDVIRGRAR---FVDPH-TVEVTG-GETLTADHIVIATGSRPRVppiPGLDE-----VRVLTSDEALELE- 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 148 riisafekaELtddPaerERLltfIIVGAGPTGVELtGQIaelanrtlsdvYSTYGtsaAKIYLLDGAPQVLPPFGKRLG 227
Cdd:COG1249  166 ---------EL---P---KSL---VVIGGGYIGLEF-AQI-----------FARLG---SEVTLVERGDRLLPGEDPEIS 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 228 RRAQRTLEKEGVNVRLNAMVTDVNEDS----VTYKNmkTDEEVTLEGATKIWSAGVAA--SPLGkmvADQAGVEADRAGR 301
Cdd:COG1249  213 EALEKALEKEGIDILTGAKVTSVEKTGdgvtVTLED--GGGEEAVEADKVLVATGRRPntDGLG---LEAAGVELDERGG 287

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 552765385 302 VSVNDDMTVGDfNNVYIIGDmmsLNRLPGLAQVAIQGGEHVAKLI 346
Cdd:COG1249  288 IKVDEYLRTSV-PGIYAIGD---VTGGPQLAHVASAEGRVAAENI 328
PRK06416 PRK06416
dihydrolipoamide dehydrogenase; Reviewed
 80-346 2.24e-14

dihydrolipoamide dehydrogenase; Reviewed


Pssm-ID: 235798 [Multi-domain]  Cd Length: 462  Bit Score: 74.80  E-value: 2.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  80 VDFVNGNVTdinLED-QTVTAELDDFSRTYSYDSLVVAAGSSqsyfgndhfAKFAPGMKTLDDalelrsRIISAFEKAEL 158
Cdd:PRK06416 107 VDIIRGEAK---LVDpNTVRVMTEDGEQTYTAKNIILATGSR---------PRELPGIEIDGR------VIWTSDEALNL 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 159 TDDPAErerlltFIIVGAGPTGVELtgqiaelanrtlSDVYSTYGtsaAKIYLLDGAPQVLPPFGKRLGRRAQRTLEKEG 238
Cdd:PRK06416 169 DEVPKS------LVVIGGGYIGVEF------------ASAYASLG---AEVTIVEALPRILPGEDKEISKLAERALKKRG 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 239 VNVRLNAMVTDV--NEDSVTYKNMKTDEEVTLEGATKIWSAGVAASP--LGkmvADQAGVEADRaGRVSVNDDM--TVGd 312
Cdd:PRK06416 228 IKIKTGAKAKKVeqTDDGVTVTLEDGGKEETLEADYVLVAVGRRPNTenLG---LEELGVKTDR-GFIEVDEQLrtNVP- 302

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 552765385 313 fnNVYIIGD----MMslnrlpgLAQVAIQGGEHVAKLI 346
Cdd:PRK06416 303 --NIYAIGDivggPM-------LAHKASAEGIIAAEAI 331
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
20-346 1.72e-12

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 68.63  E-value: 1.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  20 GGFGGLNTVKKL--KNADVEITLIDKKNHHLFQ-PMLYQVATGMISAGEVAPSTRQLLRnQDNVDFVNGN-VTDINLEDQ 95
Cdd:COG1251    9 AGMAGVRAAEELrkLDPDGEITVIGAEPHPPYNrPPLSKVLAGETDEEDLLLRPADFYE-ENGIDLRLGTrVTAIDRAAR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  96 TVTaeLDDfSRTYSYDSLVVAAGSsqSYF-----GNDhfakfAPG---MKTLDDALELRSRIisafekaeltddpAERER 167
Cdd:COG1251   88 TVT--LAD-GETLPYDKLVLATGS--RPRvppipGAD-----LPGvftLRTLDDADALRAAL-------------APGKR 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 168 LLtfiIVGAGPTGVELtgqiAE-LANRtlsdvystyGtsaAKIYLLDGAPQVLPP-FGKRLGRRAQRTLEKEGVNVRLNA 245
Cdd:COG1251  145 VV---VIGGGLIGLEA----AAaLRKR---------G---LEVTVVERAPRLLPRqLDEEAGALLQRLLEALGVEVRLGT 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 246 MVTDVN-EDSVTyknmktdeEVTLEGATKI------WSAGV-AASPLgkmvADQAGVEADRAgrVSVNDDMTVGDfNNVY 317
Cdd:COG1251  206 GVTEIEgDDRVT--------GVRLADGEELpadlvvVAIGVrPNTEL----ARAAGLAVDRG--IVVDDYLRTSD-PDIY 270

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 552765385 318 IIGD------MMSLNRLPGLAQVAIQGGEHVAKLI 346
Cdd:COG1251  271 AAGDcaehpgPVYGRRVLELVAPAYEQARVAAANL 305
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 69-321 2.87e-10

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 62.12  E-value: 2.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  69 STRQLLRNQDNVDFVNGN--VTD---INLEDQTVTAelddfsrtysyDSLVVAAGSSQSYFgndhfakfaPGMKTLDDAl 143
Cdd:PRK06292  96 GVVEGLEKKPKIDKIKGTarFVDpntVEVNGERIEA-----------KNIVIATGSRVPPI---------PGVWLILGD- 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 144 elrsRIISAFEKAELTDDPaerERLltfIIVGAGPTGVELtGQiaelanrtlsdVYSTYGtsaAKIYLLDGAPQVLPPFG 223
Cdd:PRK06292 155 ----RLLTSDDAFELDKLP---KSL---AVIGGGVIGLEL-GQ-----------ALSRLG---VKVTVFERGDRILPLED 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 224 KRLGRRAQRTLEKEgVNVRLNAMVTDV---NEDSVTYKNmKTDEEVTLEGATKIWSAGVAASpLGKMVADQAGVEADRAG 300
Cdd:PRK06292 210 PEVSKQAQKILSKE-FKIKLGAKVTSVeksGDEKVEELE-KGGKTETIEADYVLVATGRRPN-TDGLGLENTGIELDERG 286

                        250       260
                 ....*....|....*....|.
gi 552765385 301 RVSVNDDMTVGDfNNVYIIGD 321
Cdd:PRK06292 287 RPVVDEHTQTSV-PGIYAAGD 306
PRK13512 PRK13512
coenzyme A disulfide reductase; Provisional
 87-365 1.16e-09

coenzyme A disulfide reductase; Provisional


Pssm-ID: 184103 [Multi-domain]  Cd Length: 438  Bit Score: 60.18  E-value: 1.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  87 VTDINLEDQTVTA--ELDDFSRTYSYDSLVVAAGSSQSYFGNDHfakfapgmktlDDALELRSriisaFEKAELTDDPAE 164
Cdd:PRK13512  81 VIAINDERQTVTVlnRKTNEQFEESYDKLILSPGASANSLGFES-----------DITFTLRN-----LEDTDAIDQFIK 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 165 RERLLTFIIVGAGPTGVELtgqIAELANRTLSdvystygtsaakIYLLDGAPQVLPPFGKRLGRRAQRTLEKEGVNVRLN 244
Cdd:PRK13512 145 ANQVDKALVVGAGYISLEV---LENLYERGLH------------PTLIHRSDKINKLMDADMNQPILDELDKREIPYRLN 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 245 AMVTDVNEDSVTYKNMKTDE-EVTLEgatkiwsaGVAASPLGKMVaDQAGVEADRAGRVSVNDDMTVgDFNNVYIIGDMM 323
Cdd:PRK13512 210 EEIDAINGNEVTFKSGKVEHyDMIIE--------GVGTHPNSKFI-ESSNIKLDDKGFIPVNDKFET-NVPNIYAIGDII 279

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 552765385 324 SLN----RLPglAQVAIQGGEHVAKLIetkVDEESTADEKEPFEYF 365
Cdd:PRK13512 280 TSHyrhvDLP--ASVPLAWGAHRAASI---VAEQIAGNDTIEFKGF 320
PRK06327 PRK06327
dihydrolipoamide dehydrogenase; Validated
 173-346 1.15e-07

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235779 [Multi-domain]  Cd Length: 475  Bit Score: 53.78  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 173 IVGAGPTGVELtgqiaelanrtlSDVYSTYGtsaAKIYLLDGAPQVLPPFGKRLGRRAQRTLEKEGVNVRLNAMVTDVNE 252
Cdd:PRK06327 188 VIGAGVIGLEL------------GSVWRRLG---AEVTILEALPAFLAAADEQVAKEAAKAFTKQGLDIHLGVKIGEIKT 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 253 D----SVTYKNmKTDEEVTLEGATKIWSAG-VAASplGKMVADQAGVEADRAGRVSVNDDMTVGdFNNVYIIGDMMslnR 327
Cdd:PRK06327 253 GgkgvSVAYTD-ADGEAQTLEVDKLIVSIGrVPNT--DGLGLEAVGLKLDERGFIPVDDHCRTN-VPNVYAIGDVV---R 325

                        170
                 ....*....|....*....
gi 552765385 328 LPGLAQVAIQGGEHVAKLI 346
Cdd:PRK06327 326 GPMLAHKAEEEGVAVAERI 344
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 172-256 3.20e-07

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 47.58  E-value: 3.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  172 IIVGAGPTGVELTGQIAELAnrtlsdvystygtsaAKIYLLDGAPQVLPPFGKRLGRRAQRTLEKEGVNVRLNAMVTDVN 251
Cdd:pfam00070   3 VVVGGGYIGLELAGALARLG---------------SKVTVVERRDRLLPGFDPEIAKILQEKLEKNGIEFLLNTTVEAIE 67


                  ....*
gi 552765385  252 EDSVT 256
Cdd:pfam00070  68 GNGDG 72
PRK06370 PRK06370
FAD-containing oxidoreductase;
157-321 5.94e-06

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 48.27  E-value: 5.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 157 ELTDDPaerERLltfIIVGAGPTGVELtGQIaelanrtlsdvYSTYGtsaAKIYLLDGAPQVLPPFGKRLGRRAQRTLEK 236
Cdd:PRK06370 166 SLDELP---EHL---VIIGGGYIGLEF-AQM-----------FRRFG---SEVTVIERGPRLLPREDEDVAAAVREILER 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 237 EGVNVRLNAMVTDV--NEDSVTYKNMKTDEEVTLEGaTKIWsAGVAASP----LGkmvADQAGVEADRAGRVSVNDDM-- 308
Cdd:PRK06370 225 EGIDVRLNAECIRVerDGDGIAVGLDCNGGAPEITG-SHIL-VAVGRVPntddLG---LEAAGVETDARGYIKVDDQLrt 299

                        170
                 ....*....|...
gi 552765385 309 TVgdfNNVYIIGD 321
Cdd:PRK06370 300 TN---PGIYAAGD 309
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
19-321 8.89e-06

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 47.60  E-value: 8.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  19 GGGFGGLNTVKKLK--NADVEITLI-----DKKNH----HLFQpmLYQVATGMI--SAGEVApstrqllrNQDNVD-FVN 84
Cdd:PRK04965   9 GSGFAARQLVKNIRkqDAHIPITLItadsgDEYNKpdlsHVFS--QGQRADDLTrqSAGEFA--------EQFNLRlFPH 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  85 GNVTDINLEDQTVTAElddfSRTYSYDSLVVAAGSSqsyfgndhfaKFAPGMKTLDDALELRSriISAFEKAELTDDPAE 164
Cdd:PRK04965  79 TWVTDIDAEAQVVKSQ----GNQWQYDKLVLATGAS----------AFVPPIPGRELMLTLNS--QQEYRAAETQLRDAQ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 165 RerlltFIIVGAGPTGVELTGQIAelanrtlsdvystygTSAAKIYLLDGAPQVL----PPFgkrLGRRAQRTLEKEGVN 240
Cdd:PRK04965 143 R-----VLVVGGGLIGTELAMDLC---------------RAGKAVTLVDNAASLLaslmPPE---VSSRLQHRLTEMGVH 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 241 VRLNAMVTDVNEDSVTYKnMKTDEEVTLEGATKIWSAGVAASplgKMVADQAGVEADRAgrVSVNDDMTVGDfNNVYIIG 320
Cdd:PRK04965 200 LLLKSQLQGLEKTDSGIR-ATLDSGRSIEVDAVIAAAGLRPN---TALARRAGLAVNRG--IVVDSYLQTSA-PDIYALG 272


                 .
gi 552765385 321 D 321
Cdd:PRK04965 273 D 273
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
79-322 4.28e-05

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 45.11  E-value: 4.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385  79 NVDFVNGNVTDINLEDQTVTAELDDfSRTYSYDSLVVAAGSSQSYFGndhfakfapgmktLDDALELRSRIISAFekaeL 158
Cdd:COG0492   71 GAEILLEEVTSVDKDDGPFRVTTDD-GTEYEAKAVIIATGAGPRKLG-------------LPGEEEFEGRGVSYC----A 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 159 TDDPAE-RERllTFIIVGAGPTGVELTGQIAELANR-TLsdVYSTYGTSAAKIYlldgapqvlppfgkrlgrrAQRTLEK 236
Cdd:COG0492  133 TCDGFFfRGK--DVVVVGGGDSALEEALYLTKFASKvTL--IHRRDELRASKIL-------------------VERLRAN 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 237 EGVNVRLNAMVTDVNED----SVTYKNMKTDEEVTLE--------GATkiwsagvaasPLGKMVADQaGVEADRAGRVSV 304
Cdd:COG0492  190 PKIEVLWNTEVTEIEGDgrveGVTLKNVKTGEEKELEvdgvfvaiGLK----------PNTELLKGL-GLELDEDGYIVV 258

                        250       260
                 ....*....|....*....|
gi 552765385 305 NDDM--TVgdfNNVYIIGDM 322
Cdd:COG0492  259 DEDMetSV---PGVFAAGDV 275
PRK07251 PRK07251
FAD-containing oxidoreductase;
173-321 6.28e-03

FAD-containing oxidoreductase;


Pssm-ID: 180907 [Multi-domain]  Cd Length: 438  Bit Score: 38.96  E-value: 6.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 552765385 173 IVGAGPTGVELTGQIAELanrtlsdvystygtsAAKIYLLDGAPQVLPPFGKRLGRRAQRTLEKEGVNVRLNAMVTDVne 252
Cdd:PRK07251 162 IIGGGNIGLEFAGLYNKL---------------GSKVTVLDAASTILPREEPSVAALAKQYMEEDGITFLLNAHTTEV-- 224

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 552765385 253 dsvtyKNMKTDEEVTLEGATKIWSAGVAAS-------PLGKMVADqagVEADRAGRVSVND--DMTVgdfNNVYIIGD 321
Cdd:PRK07251 225 -----KNDGDQVLVVTEDETYRFDALLYATgrkpntePLGLENTD---IELTERGAIKVDDycQTSV---PGVFAVGD 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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