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Conserved domains on  [gi|553944881|ref|WP_023149734|]
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MULTISPECIES: IS66-like element ISCro1 family transposase [Enterobacteriaceae]

Protein Classification

IS66 family transposase( domain architecture ID 15980350)

IS66 family transposase binds to the end of a transposon and catalyze the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Gene Ontology:  GO:0004803|GO:0032196|GO:0003677
PubMed:  20615441|17165262|20079432

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS66 NF033517
IS66 family transposase; Members of this protein family are DDE transposases from the IS66 ...
 105-502 3.51e-172

IS66 family transposase; Members of this protein family are DDE transposases from the IS66 family insertion sequences, which typically consist of two accessary genes (TnpA and TnpB) and the third gene encoding the transposase.


:

Pssm-ID: 468053 [Multi-domain]  Cd Length: 388  Bit Score: 490.94  E-value: 3.51e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 105 RQSSARKPLPASLPRETRVIRPEEecCPACGGE-LSSLGCDVSEQLELISSAFKVIETQRPKQACCRCDHIVQAPVPSKP 183
Cdd:NF033517   4 HKGKTRKPLPDHLPREEVVHEPES--CPCCGGAlLHRIGEEVSEQLEIIPAKFEVTEYVRPKYACRHCGTVVQAPAPARV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 184 IARSYAGAGLLAHVVTGKYADHLPLYRQSEIYRRQ-GVELSRATLGRWTGAVAELLEPLYDVLRQYVLMPGKVHADDIPV 262
Cdd:NF033517  82 IPKGQAGPRLLAHVAVLKYADHLPLYRQQQILARLfGIELSRGTLANWVGRAAELLEPLYDALKEELLAAPVLHADETGV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 263 PVQEPGSGKTrtARLWVYVRDdrnagsqmPPAVWFAYSPDRKGIHPQNYLAGYSGVLQADAYGGYRALYesgRITEAACM 342
Cdd:NF033517 162 PVLEPGRGKT--GWLWVYASA--------PPAVLFDYAPSRGGEVPEALLEGFNGVLQSDGYAGYNKLA---AVTHAGCW 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 343 AHARRKIHDVHARAPTYITTEALQRIGELYAIEAEVRGCSAEQRLAARKARAAPLMQSLYDWIQQQMKTLSRHSDTAKAF 422
Cdd:NF033517 229 AHLRRKFQEAAERKGKSIAEEALKRIGELYAIERRIRGLSPEERRALRQERSRPLLDELKAWLEAGLAGVLPKSPLGKAI 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 423 AYLLKQWDALNVYCSNGWVEIDNNIAENALRGVAVGRKNWMFAGSDSGGEHAAVLYSLIGTCRLNNVEPEKWLRYVIEHI 502
Cdd:NF033517 309 RYLLNRWDALLRFLDDGRVPIDNNAAERAIRPVVLGRKNSLFAGSDRGAEAAARIYSLIETAKLNGLNPYAYLRDVLTRL 388
LZ_Tnp_IS66 pfam13007
Transposase C of IS166 homeodomain; This is a leucine-zipper-like or homeodomain-like region ...
 46-122 4.14e-13

Transposase C of IS166 homeodomain; This is a leucine-zipper-like or homeodomain-like region of transposase TnpC of insertion element IS66.


:

Pssm-ID: 463771 [Multi-domain]  Cd Length: 67  Bit Score: 64.21  E-value: 4.14e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 553944881   46 RLKALVAKLQRMQFGKSSEKLRAkterqiqeaqERISALQEEMAETLGEQYDPVLPSALRQSSARKPLPASLPRETR 122
Cdd:pfam13007   1 RLEEQLALLKRRLFGRSSEKLDP----------EQLELALEELEAEEAEVEAEARASKKRKKPGRKPLPAHLPREEV 67
 
Name Accession Description Interval E-value
transpos_IS66 NF033517
IS66 family transposase; Members of this protein family are DDE transposases from the IS66 ...
 105-502 3.51e-172

IS66 family transposase; Members of this protein family are DDE transposases from the IS66 family insertion sequences, which typically consist of two accessary genes (TnpA and TnpB) and the third gene encoding the transposase.


Pssm-ID: 468053 [Multi-domain]  Cd Length: 388  Bit Score: 490.94  E-value: 3.51e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 105 RQSSARKPLPASLPRETRVIRPEEecCPACGGE-LSSLGCDVSEQLELISSAFKVIETQRPKQACCRCDHIVQAPVPSKP 183
Cdd:NF033517   4 HKGKTRKPLPDHLPREEVVHEPES--CPCCGGAlLHRIGEEVSEQLEIIPAKFEVTEYVRPKYACRHCGTVVQAPAPARV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 184 IARSYAGAGLLAHVVTGKYADHLPLYRQSEIYRRQ-GVELSRATLGRWTGAVAELLEPLYDVLRQYVLMPGKVHADDIPV 262
Cdd:NF033517  82 IPKGQAGPRLLAHVAVLKYADHLPLYRQQQILARLfGIELSRGTLANWVGRAAELLEPLYDALKEELLAAPVLHADETGV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 263 PVQEPGSGKTrtARLWVYVRDdrnagsqmPPAVWFAYSPDRKGIHPQNYLAGYSGVLQADAYGGYRALYesgRITEAACM 342
Cdd:NF033517 162 PVLEPGRGKT--GWLWVYASA--------PPAVLFDYAPSRGGEVPEALLEGFNGVLQSDGYAGYNKLA---AVTHAGCW 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 343 AHARRKIHDVHARAPTYITTEALQRIGELYAIEAEVRGCSAEQRLAARKARAAPLMQSLYDWIQQQMKTLSRHSDTAKAF 422
Cdd:NF033517 229 AHLRRKFQEAAERKGKSIAEEALKRIGELYAIERRIRGLSPEERRALRQERSRPLLDELKAWLEAGLAGVLPKSPLGKAI 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 423 AYLLKQWDALNVYCSNGWVEIDNNIAENALRGVAVGRKNWMFAGSDSGGEHAAVLYSLIGTCRLNNVEPEKWLRYVIEHI 502
Cdd:NF033517 309 RYLLNRWDALLRFLDDGRVPIDNNAAERAIRPVVLGRKNSLFAGSDRGAEAAARIYSLIETAKLNGLNPYAYLRDVLTRL 388
DDE_Tnp_IS66 pfam03050
Transposase IS66 family; Transposase proteins are necessary for efficient DNA transposition. ...
 186-472 2.28e-122

Transposase IS66 family; Transposase proteins are necessary for efficient DNA transposition. This family includes IS66 from Agrobacterium tumefaciens.


Pssm-ID: 427113 [Multi-domain]  Cd Length: 281  Bit Score: 360.03  E-value: 2.28e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881  186 RSYAGAGLLAHVVTGKYADHLPLYRQSEIYRRQGVELSRATLGRWTGAVAELLEPLYDVLRQYVLMPGKVHADDIPVPVQ 265
Cdd:pfam03050   1 KSLAGPSLLALILVLKYADHLPLYRQEDILARLGVELSRGTLANWVGRAAELLEPLVDALRAALLESPVIHADETPLRVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881  266 EPGSGKTRTARLWVYVRDDRNagsqmPPAVWFAYSPDRKGIHPQNYLAGYSGVLQADAYGGYRALYEsGRITEAACMAHA 345
Cdd:pfam03050  81 KPGRGKGKKGWLWVYVTDDRP-----PPAVLFHYHPSRGGEHPQALLGGFRGVLQTDGYAGYNKLAR-GQVTHAGCWAHA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881  346 RRKIHDVHARAPTyITTEALQRIGELYAIEAEVRGCSAEQRLAARKARAAPLMQSLYDWIQQQMKTLSRHSDTAKAFAYL 425
Cdd:pfam03050 155 RRKFFDAHKAGSP-LAAQALARIGKLYAIEREIRDLTPEERLALRQEYSRPLLDELEAWLEEQLRGVLPKSALGKAIRYL 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 553944881  426 LKQWDALNVYCSNGWVEIDNNIAENALRGVAVGRKNWMFAGSDSGGE 472
Cdd:pfam03050 234 LNRWEALLRFLEDGRVPIDNNQAERAIRPVVLGRKNWLFAGSDEGAE 280
COG3436 COG3436
Transposase [Mobilome: prophages, transposons];
43-460 7.63e-91

Transposase [Mobilome: prophages, transposons];


Pssm-ID: 442662 [Multi-domain]  Cd Length: 416  Bit Score: 284.23  E-value: 7.63e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881  43 EINRLKALVAKLQRMQFGKSSEKLRaktERQIQEAQERISALQEEMAETLGEQYDPVLPSALRQSSARKPLPASLPRETR 122
Cdd:COG3436    3 EEEELILLLLLLERLRLRRLRERES---RLESQPELQLLELEEEAEEEEEAAEEAEAKTTKKKPKPGRKPMPEHLPREEV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 123 VIRPEE-ECCPAcggeLSSLGCDVSEQLELISSAFKVIETQRPKQACCRCDH--IVQAPVPSKPIARSYAGAGLLAHVVT 199
Cdd:COG3436   80 LHEPTDmRKIDG----LAAIGEEVSEELDLDPGALFVFRNRRDKYKCLYCDGtgLVYAPAPAKRLEKGLAGPGLLAHILV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 200 GKYADHLPLYRQSEIYRRQGVELSRATLGRWTGAVAELLEPLYDVLRQYVLMPGKVHADDIPVPVQEPGSGKTRTARLWV 279
Cdd:COG3436  156 SKFVDHLPLYRQEEIFARLGVELSRSTLLNWVGRAAELLEPLLEGLDERLLAAPVLHADETPVQVLDEGKGKTVTASYWW 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 280 YVRDDRNAGSQMPPAVWFAYSPDRKGIHPQNYLAGYSGVLQADAYGGYRALYESGRITEAACMAHARRKIHDVHARAPTY 359
Cdd:COG3436  236 VYRDGRPSRGPVVYDAYRSRRGARAGLVLDGGLGGGLGDDYADGYAALLRLAELGCAAAARRRRKAAAAALKKLAKKAAA 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 360 ITTEALQRIGELYAIEAEVRGCSAEQRLAARKARAAPLMQSLYDWIQQQMKTLSRHSDTAKAFAYLLKQWDALNVYCSNG 439
Cdd:COG3436  316 AAAGLAAEEALLRIEELRKEERLRERRRERRPRRLLLLKALLLLLLLLLPLLPPGKALLYAALARAARLLALLDRLLDLL 395

                        410       420
                 ....*....|....*....|.
gi 553944881 440 WVEIDNNIAENALRGVAVGRK 460
Cdd:COG3436  396 RNNDENNAERNALRRRNNLFA 416
LZ_Tnp_IS66 pfam13007
Transposase C of IS166 homeodomain; This is a leucine-zipper-like or homeodomain-like region ...
 46-122 4.14e-13

Transposase C of IS166 homeodomain; This is a leucine-zipper-like or homeodomain-like region of transposase TnpC of insertion element IS66.


Pssm-ID: 463771 [Multi-domain]  Cd Length: 67  Bit Score: 64.21  E-value: 4.14e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 553944881   46 RLKALVAKLQRMQFGKSSEKLRAkterqiqeaqERISALQEEMAETLGEQYDPVLPSALRQSSARKPLPASLPRETR 122
Cdd:pfam13007   1 RLEEQLALLKRRLFGRSSEKLDP----------EQLELALEELEAEEAEVEAEARASKKRKKPGRKPLPAHLPREEV 67
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 12-92 3.18e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 37.95  E-value: 3.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881    12 LRALLQTQQDTIRQMAEYNRLLSQRVAAYASEINRLKALVAKLQRmQFGKSSEKLRAKTERQIQEAQERISALQEEMAET 91
Cdd:smart00935   6 VQKILQESPAGKAAQKQLEKEFKKRQAELEKLEKELQKLKEKLQK-DAATLSEAAREKKEKELQKKVQEFQRKQQKLQQD 84


                   .
gi 553944881    92 L 92
Cdd:smart00935  85 L 85
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 2-96 5.43e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.04  E-value: 5.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881   2 DTSLAHENARLRALlQTQQDTIRqmAEYNRLLSQrVAAYASEINRLKALVAKLQrmqfgkssEKLrAKTERQIQEAQERI 81
Cdd:COG3883   15 DPQIQAKQKELSEL-QAELEAAQ--AELDALQAE-LEELNEEYNELQAELEALQ--------AEI-DKLQAEIAEAEAEI 81

                         90
                 ....*....|....*
gi 553944881  82 SALQEEMAETLGEQY 96
Cdd:COG3883   82 EERREELGERARALY 96
 
Name Accession Description Interval E-value
transpos_IS66 NF033517
IS66 family transposase; Members of this protein family are DDE transposases from the IS66 ...
 105-502 3.51e-172

IS66 family transposase; Members of this protein family are DDE transposases from the IS66 family insertion sequences, which typically consist of two accessary genes (TnpA and TnpB) and the third gene encoding the transposase.


Pssm-ID: 468053 [Multi-domain]  Cd Length: 388  Bit Score: 490.94  E-value: 3.51e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 105 RQSSARKPLPASLPRETRVIRPEEecCPACGGE-LSSLGCDVSEQLELISSAFKVIETQRPKQACCRCDHIVQAPVPSKP 183
Cdd:NF033517   4 HKGKTRKPLPDHLPREEVVHEPES--CPCCGGAlLHRIGEEVSEQLEIIPAKFEVTEYVRPKYACRHCGTVVQAPAPARV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 184 IARSYAGAGLLAHVVTGKYADHLPLYRQSEIYRRQ-GVELSRATLGRWTGAVAELLEPLYDVLRQYVLMPGKVHADDIPV 262
Cdd:NF033517  82 IPKGQAGPRLLAHVAVLKYADHLPLYRQQQILARLfGIELSRGTLANWVGRAAELLEPLYDALKEELLAAPVLHADETGV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 263 PVQEPGSGKTrtARLWVYVRDdrnagsqmPPAVWFAYSPDRKGIHPQNYLAGYSGVLQADAYGGYRALYesgRITEAACM 342
Cdd:NF033517 162 PVLEPGRGKT--GWLWVYASA--------PPAVLFDYAPSRGGEVPEALLEGFNGVLQSDGYAGYNKLA---AVTHAGCW 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 343 AHARRKIHDVHARAPTYITTEALQRIGELYAIEAEVRGCSAEQRLAARKARAAPLMQSLYDWIQQQMKTLSRHSDTAKAF 422
Cdd:NF033517 229 AHLRRKFQEAAERKGKSIAEEALKRIGELYAIERRIRGLSPEERRALRQERSRPLLDELKAWLEAGLAGVLPKSPLGKAI 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 423 AYLLKQWDALNVYCSNGWVEIDNNIAENALRGVAVGRKNWMFAGSDSGGEHAAVLYSLIGTCRLNNVEPEKWLRYVIEHI 502
Cdd:NF033517 309 RYLLNRWDALLRFLDDGRVPIDNNAAERAIRPVVLGRKNSLFAGSDRGAEAAARIYSLIETAKLNGLNPYAYLRDVLTRL 388
DDE_Tnp_IS66 pfam03050
Transposase IS66 family; Transposase proteins are necessary for efficient DNA transposition. ...
 186-472 2.28e-122

Transposase IS66 family; Transposase proteins are necessary for efficient DNA transposition. This family includes IS66 from Agrobacterium tumefaciens.


Pssm-ID: 427113 [Multi-domain]  Cd Length: 281  Bit Score: 360.03  E-value: 2.28e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881  186 RSYAGAGLLAHVVTGKYADHLPLYRQSEIYRRQGVELSRATLGRWTGAVAELLEPLYDVLRQYVLMPGKVHADDIPVPVQ 265
Cdd:pfam03050   1 KSLAGPSLLALILVLKYADHLPLYRQEDILARLGVELSRGTLANWVGRAAELLEPLVDALRAALLESPVIHADETPLRVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881  266 EPGSGKTRTARLWVYVRDDRNagsqmPPAVWFAYSPDRKGIHPQNYLAGYSGVLQADAYGGYRALYEsGRITEAACMAHA 345
Cdd:pfam03050  81 KPGRGKGKKGWLWVYVTDDRP-----PPAVLFHYHPSRGGEHPQALLGGFRGVLQTDGYAGYNKLAR-GQVTHAGCWAHA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881  346 RRKIHDVHARAPTyITTEALQRIGELYAIEAEVRGCSAEQRLAARKARAAPLMQSLYDWIQQQMKTLSRHSDTAKAFAYL 425
Cdd:pfam03050 155 RRKFFDAHKAGSP-LAAQALARIGKLYAIEREIRDLTPEERLALRQEYSRPLLDELEAWLEEQLRGVLPKSALGKAIRYL 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 553944881  426 LKQWDALNVYCSNGWVEIDNNIAENALRGVAVGRKNWMFAGSDSGGE 472
Cdd:pfam03050 234 LNRWEALLRFLEDGRVPIDNNQAERAIRPVVLGRKNWLFAGSDEGAE 280
COG3436 COG3436
Transposase [Mobilome: prophages, transposons];
43-460 7.63e-91

Transposase [Mobilome: prophages, transposons];


Pssm-ID: 442662 [Multi-domain]  Cd Length: 416  Bit Score: 284.23  E-value: 7.63e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881  43 EINRLKALVAKLQRMQFGKSSEKLRaktERQIQEAQERISALQEEMAETLGEQYDPVLPSALRQSSARKPLPASLPRETR 122
Cdd:COG3436    3 EEEELILLLLLLERLRLRRLRERES---RLESQPELQLLELEEEAEEEEEAAEEAEAKTTKKKPKPGRKPMPEHLPREEV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 123 VIRPEE-ECCPAcggeLSSLGCDVSEQLELISSAFKVIETQRPKQACCRCDH--IVQAPVPSKPIARSYAGAGLLAHVVT 199
Cdd:COG3436   80 LHEPTDmRKIDG----LAAIGEEVSEELDLDPGALFVFRNRRDKYKCLYCDGtgLVYAPAPAKRLEKGLAGPGLLAHILV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 200 GKYADHLPLYRQSEIYRRQGVELSRATLGRWTGAVAELLEPLYDVLRQYVLMPGKVHADDIPVPVQEPGSGKTRTARLWV 279
Cdd:COG3436  156 SKFVDHLPLYRQEEIFARLGVELSRSTLLNWVGRAAELLEPLLEGLDERLLAAPVLHADETPVQVLDEGKGKTVTASYWW 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 280 YVRDDRNAGSQMPPAVWFAYSPDRKGIHPQNYLAGYSGVLQADAYGGYRALYESGRITEAACMAHARRKIHDVHARAPTY 359
Cdd:COG3436  236 VYRDGRPSRGPVVYDAYRSRRGARAGLVLDGGLGGGLGDDYADGYAALLRLAELGCAAAARRRRKAAAAALKKLAKKAAA 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881 360 ITTEALQRIGELYAIEAEVRGCSAEQRLAARKARAAPLMQSLYDWIQQQMKTLSRHSDTAKAFAYLLKQWDALNVYCSNG 439
Cdd:COG3436  316 AAAGLAAEEALLRIEELRKEERLRERRRERRPRRLLLLKALLLLLLLLLPLLPPGKALLYAALARAARLLALLDRLLDLL 395

                        410       420
                 ....*....|....*....|.
gi 553944881 440 WVEIDNNIAENALRGVAVGRK 460
Cdd:COG3436  396 RNNDENNAERNALRRRNNLFA 416
DDE_Tnp_IS66_C pfam13817
IS66 C-terminal element;
479-516 1.51e-13

IS66 C-terminal element;


Pssm-ID: 433500  Cd Length: 39  Bit Score: 64.72  E-value: 1.51e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 553944881  479 SLIGTCRLNNVEPEKWLRYVIEHIQD-WPANRVRDLLPW 516
Cdd:pfam13817   1 SLIETAKLNGLDPYAYLTDVLERLPDhHPAERLDELLPW 39
LZ_Tnp_IS66 pfam13007
Transposase C of IS166 homeodomain; This is a leucine-zipper-like or homeodomain-like region ...
 46-122 4.14e-13

Transposase C of IS166 homeodomain; This is a leucine-zipper-like or homeodomain-like region of transposase TnpC of insertion element IS66.


Pssm-ID: 463771 [Multi-domain]  Cd Length: 67  Bit Score: 64.21  E-value: 4.14e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 553944881   46 RLKALVAKLQRMQFGKSSEKLRAkterqiqeaqERISALQEEMAETLGEQYDPVLPSALRQSSARKPLPASLPRETR 122
Cdd:pfam13007   1 RLEEQLALLKRRLFGRSSEKLDP----------EQLELALEELEAEEAEVEAEARASKKRKKPGRKPLPAHLPREEV 67
zf-IS66 pfam13005
zinc-finger binding domain of transposase IS66; This is a zinc-finger region of the N-terminus ...
 128-172 4.54e-12

zinc-finger binding domain of transposase IS66; This is a zinc-finger region of the N-terminus of the insertion element IS66 transposase.


Pssm-ID: 463770 [Multi-domain]  Cd Length: 46  Bit Score: 60.79  E-value: 4.54e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 553944881  128 EECCPACGGELSSLGCD-VSEQLELISSAFKVIETQRPKQACCRCD 172
Cdd:pfam13005   1 ERVCPCCGGLLHPIGEDeVREELDIPPAKFRVIEHIRPKYACRHCE 46
ERM_helical pfam20492
Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...
 8-90 9.56e-05

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain (pfam00769). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.


Pssm-ID: 466641 [Multi-domain]  Cd Length: 120  Bit Score: 41.83  E-value: 9.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881    8 ENARLRALLQTQQDTIRQMAEYNRLLSQRVAAYASEINRLKALVAKLQRMQfgKSSEKLRAKTERQIQEAQERISALQEE 87
Cdd:pfam20492  21 ETKKAQEELEESEETAEELEEERRQAEEEAERLEQKRQEAEEEKERLEESA--EMEAEEKEQLEAELAEAQEEIARLEEE 98


                  ...
gi 553944881   88 MAE 90
Cdd:pfam20492  99 VER 101
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 12-92 3.18e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 37.95  E-value: 3.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881    12 LRALLQTQQDTIRQMAEYNRLLSQRVAAYASEINRLKALVAKLQRmQFGKSSEKLRAKTERQIQEAQERISALQEEMAET 91
Cdd:smart00935   6 VQKILQESPAGKAAQKQLEKEFKKRQAELEKLEKELQKLKEKLQK-DAATLSEAAREKKEKELQKKVQEFQRKQQKLQQD 84


                   .
gi 553944881    92 L 92
Cdd:smart00935  85 L 85
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 2-96 5.43e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.04  E-value: 5.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553944881   2 DTSLAHENARLRALlQTQQDTIRqmAEYNRLLSQrVAAYASEINRLKALVAKLQrmqfgkssEKLrAKTERQIQEAQERI 81
Cdd:COG3883   15 DPQIQAKQKELSEL-QAELEAAQ--AELDALQAE-LEELNEEYNELQAELEALQ--------AEI-DKLQAEIAEAEAEI 81

                         90
                 ....*....|....*
gi 553944881  82 SALQEEMAETLGEQY 96
Cdd:COG3883   82 EERREELGERARALY 96
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 26-100 8.76e-03

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 36.79  E-value: 8.76e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 553944881   26 MAEYNRLLSQRVAAYASEINRLKALVAKLQRMqfGKSSEKLRAKTERQIQEAQERISALQEEMAETLGEQYDPVL 100
Cdd:pfam03938  21 QAQLEKKFKKRQAELEAKQKELQKLYEELQKD--GALLEEEREEKEQELQKKEQELQQLQQKAQQELQKKQQELL 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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