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Conserved domains on  [gi|556268249|ref|WP_023288321|]
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MULTISPECIES: RpiB/LacA/LacB family sugar-phosphate isomerase [Klebsiella]

Protein Classification

RpiB/LacA/LacB family sugar-phosphate isomerase( domain architecture ID 10002173)

RpiB/LacA/LacB family sugar-phosphate isomerase similar to ribose 5-phosphate isomerase B, which catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RpiB COG0698
Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Ribose 5-phosphate ...
 4-134 2.65e-41

Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Ribose 5-phosphate isomerase RpiB is part of the Pathway/BioSystem: Pentose phosphate pathway


:

Pssm-ID: 440462  Cd Length: 149  Bit Score: 135.98  E-value: 2.65e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556268249   4 KIAIASDDVGFERKEEIKKYLvEEKGAQVV------YDPVkckedgvnNFARLADEMAGVIQRDECRLGIYICGTGIGFT 77
Cdd:COG0698    2 KIAIGSDHAGFELKEAIKEYL-EEKGHEVVdfgtysEDSV--------DYPDFAIKVAEAVASGEADRGILICGTGIGMS 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 556268249  78 CQVNKHWGIRAVAVTNPYSAKRARLSNNAQVIGLGCRVNDLEYTKMIVDAWFDNPFD 134
Cdd:COG0698   73 IAANKVPGIRAALCHDPYSARLAREHNDANVLCLGARVIGPELAKEIVDAFLATEFE 129
 
Name Accession Description Interval E-value
RpiB COG0698
Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Ribose 5-phosphate ...
 4-134 2.65e-41

Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Ribose 5-phosphate isomerase RpiB is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440462  Cd Length: 149  Bit Score: 135.98  E-value: 2.65e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556268249   4 KIAIASDDVGFERKEEIKKYLvEEKGAQVV------YDPVkckedgvnNFARLADEMAGVIQRDECRLGIYICGTGIGFT 77
Cdd:COG0698    2 KIAIGSDHAGFELKEAIKEYL-EEKGHEVVdfgtysEDSV--------DYPDFAIKVAEAVASGEADRGILICGTGIGMS 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 556268249  78 CQVNKHWGIRAVAVTNPYSAKRARLSNNAQVIGLGCRVNDLEYTKMIVDAWFDNPFD 134
Cdd:COG0698   73 IAANKVPGIRAALCHDPYSARLAREHNDANVLCLGARVIGPELAKEIVDAFLATEFE 129
PRK05571 PRK05571
ribose-5-phosphate isomerase B; Provisional
 4-134 6.97e-39

ribose-5-phosphate isomerase B; Provisional


Pssm-ID: 235509  Cd Length: 148  Bit Score: 129.51  E-value: 6.97e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556268249   4 KIAIASDDVGFERKEEIKKYLvEEKGAQVVyDPVKCKEDGVNNFARLADEMAGVIQRDECRLGIYICGTGIGFTCQVNKH 83
Cdd:PRK05571   2 KIAIGSDHAGFELKEEIIEHL-EELGHEVI-DLGPDSYDASVDYPDYAKKVAEAVVAGEADRGILICGTGIGMSIAANKV 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 556268249  84 WGIRAVAVTNPYSAKRARLSNNAQVIGLGCRVNDLEYTKMIVDAWFDNPFD 134
Cdd:PRK05571  80 KGIRAALCHDTYSAHLAREHNNANVLALGARVIGPELAKDIVDAFLATEFE 130
LacAB_rpiB pfam02502
Ribose/Galactose Isomerase; This family of proteins contains the sugar isomerase enzymes ...
 5-134 1.42e-37

Ribose/Galactose Isomerase; This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).


Pssm-ID: 460573  Cd Length: 134  Bit Score: 125.96  E-value: 1.42e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556268249    5 IAIASDDVGFERKEEIKKYLvEEKGAQVV----YDPVKCkedgvnNFARLADEMAGVIQRDECRLGIYICGTGIGFTCQV 80
Cdd:pfam02502   1 IAIGSDHAGFELKEEIKEYL-EEKGHEVIdfgtYSEESV------DYPDYAHKVAEAVASGEADRGILICGTGIGMSIAA 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 556268249   81 NKHWGIRAVAVTNPYSAKRARLSNNAQVIGLGCRVNDLEYTKMIVDAWFDNPFD 134
Cdd:pfam02502  74 NKVPGIRAALCHDPYSAKLAREHNDANVLCLGARVIGPELAKEIVDAFLNTEFE 127
rpiB_lacA_lacB TIGR00689
sugar-phosphate isomerase, RpiB/LacA/LacB family; Proteins of known function in this family ...
 5-133 1.05e-31

sugar-phosphate isomerase, RpiB/LacA/LacB family; Proteins of known function in this family act as sugar (pentose and/or hexose)-phosphate isomerases, including the LacA and LacB subunits of galactose-6-phosphate isomerases from Gram-positive bacteria and RpiB. RpiB is the second ribose phosphate isomerase of E. coli. It lacks homology to RpiA, its inducer is unknown (but is not ribose), and it can be replaced by the homologous galactose-6-phosphate isomerase of Streptococcus mutans, all of which suggests that the ribose phosphate isomerase activity of RpiB is a secondary function. On the other hand, there appear to be a significant number of species which contain rpiB, lack rpiA and seem to require rpi activity in order to complete the pentose phosphate pathway.


Pssm-ID: 129772  Cd Length: 144  Bit Score: 111.32  E-value: 1.05e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556268249    5 IAIASDDVGFERKEEIKKYLvEEKGAQVVydPVKCKEDGVNNFARLADEMAGVIQRDECRLGIYICGTGIGFTCQVNKHW 84
Cdd:TIGR00689   1 IAIGSDHAGLELKSEIIEHL-KQKGHEVI--DCGTLYDERVDYPDYAKLVADKVVAGEVSLGILICGTGIGMSIAANKFK 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 556268249   85 GIRAVAVTNPYSAKRARLSNNAQVIGLGCRVNDLEYTKMIVDAWFDNPF 133
Cdd:TIGR00689  78 GIRAALCVDEYTAALARQHNDANVLCLGSRVVGVELALSIVDAFLTTQF 126
 
Name Accession Description Interval E-value
RpiB COG0698
Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Ribose 5-phosphate ...
 4-134 2.65e-41

Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Ribose 5-phosphate isomerase RpiB is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440462  Cd Length: 149  Bit Score: 135.98  E-value: 2.65e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556268249   4 KIAIASDDVGFERKEEIKKYLvEEKGAQVV------YDPVkckedgvnNFARLADEMAGVIQRDECRLGIYICGTGIGFT 77
Cdd:COG0698    2 KIAIGSDHAGFELKEAIKEYL-EEKGHEVVdfgtysEDSV--------DYPDFAIKVAEAVASGEADRGILICGTGIGMS 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 556268249  78 CQVNKHWGIRAVAVTNPYSAKRARLSNNAQVIGLGCRVNDLEYTKMIVDAWFDNPFD 134
Cdd:COG0698   73 IAANKVPGIRAALCHDPYSARLAREHNDANVLCLGARVIGPELAKEIVDAFLATEFE 129
PRK05571 PRK05571
ribose-5-phosphate isomerase B; Provisional
 4-134 6.97e-39

ribose-5-phosphate isomerase B; Provisional


Pssm-ID: 235509  Cd Length: 148  Bit Score: 129.51  E-value: 6.97e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556268249   4 KIAIASDDVGFERKEEIKKYLvEEKGAQVVyDPVKCKEDGVNNFARLADEMAGVIQRDECRLGIYICGTGIGFTCQVNKH 83
Cdd:PRK05571   2 KIAIGSDHAGFELKEEIIEHL-EELGHEVI-DLGPDSYDASVDYPDYAKKVAEAVVAGEADRGILICGTGIGMSIAANKV 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 556268249  84 WGIRAVAVTNPYSAKRARLSNNAQVIGLGCRVNDLEYTKMIVDAWFDNPFD 134
Cdd:PRK05571  80 KGIRAALCHDTYSAHLAREHNNANVLALGARVIGPELAKDIVDAFLATEFE 130
LacAB_rpiB pfam02502
Ribose/Galactose Isomerase; This family of proteins contains the sugar isomerase enzymes ...
 5-134 1.42e-37

Ribose/Galactose Isomerase; This family of proteins contains the sugar isomerase enzymes ribose 5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB).


Pssm-ID: 460573  Cd Length: 134  Bit Score: 125.96  E-value: 1.42e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556268249    5 IAIASDDVGFERKEEIKKYLvEEKGAQVV----YDPVKCkedgvnNFARLADEMAGVIQRDECRLGIYICGTGIGFTCQV 80
Cdd:pfam02502   1 IAIGSDHAGFELKEEIKEYL-EEKGHEVIdfgtYSEESV------DYPDYAHKVAEAVASGEADRGILICGTGIGMSIAA 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 556268249   81 NKHWGIRAVAVTNPYSAKRARLSNNAQVIGLGCRVNDLEYTKMIVDAWFDNPFD 134
Cdd:pfam02502  74 NKVPGIRAALCHDPYSAKLAREHNDANVLCLGARVIGPELAKEIVDAFLNTEFE 127
rpiB_lacA_lacB TIGR00689
sugar-phosphate isomerase, RpiB/LacA/LacB family; Proteins of known function in this family ...
 5-133 1.05e-31

sugar-phosphate isomerase, RpiB/LacA/LacB family; Proteins of known function in this family act as sugar (pentose and/or hexose)-phosphate isomerases, including the LacA and LacB subunits of galactose-6-phosphate isomerases from Gram-positive bacteria and RpiB. RpiB is the second ribose phosphate isomerase of E. coli. It lacks homology to RpiA, its inducer is unknown (but is not ribose), and it can be replaced by the homologous galactose-6-phosphate isomerase of Streptococcus mutans, all of which suggests that the ribose phosphate isomerase activity of RpiB is a secondary function. On the other hand, there appear to be a significant number of species which contain rpiB, lack rpiA and seem to require rpi activity in order to complete the pentose phosphate pathway.


Pssm-ID: 129772  Cd Length: 144  Bit Score: 111.32  E-value: 1.05e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556268249    5 IAIASDDVGFERKEEIKKYLvEEKGAQVVydPVKCKEDGVNNFARLADEMAGVIQRDECRLGIYICGTGIGFTCQVNKHW 84
Cdd:TIGR00689   1 IAIGSDHAGLELKSEIIEHL-KQKGHEVI--DCGTLYDERVDYPDYAKLVADKVVAGEVSLGILICGTGIGMSIAANKFK 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 556268249   85 GIRAVAVTNPYSAKRARLSNNAQVIGLGCRVNDLEYTKMIVDAWFDNPF 133
Cdd:TIGR00689  78 GIRAALCVDEYTAALARQHNDANVLCLGSRVVGVELALSIVDAFLTTQF 126
rpiB TIGR01120
ribose 5-phosphate isomerase B; Involved in the non-oxidative branch of the pentose phospate ...
 4-134 3.96e-29

ribose 5-phosphate isomerase B; Involved in the non-oxidative branch of the pentose phospate pathway. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 130190  Cd Length: 143  Bit Score: 104.61  E-value: 3.96e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556268249    4 KIAIASDDVGFERKEEIKKYLvEEKGAQVVYDPVKCKEDgvNNFARLADEMAGVIQRDECRLGIYICGTGIGFTCQVNKH 83
Cdd:TIGR01120   1 KIAIGSDHAGFILKEEIKAFL-VERGVKVIDKGTWSSER--TDYPHYAKQVALAVAGGEVDGGILICGTGIGMSIAANKF 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 556268249   84 WGIRAVAVTNPYSAKRARLSNNAQVIGLGCRVNDLEYTKMIVDAWFDNPFD 134
Cdd:TIGR01120  78 AGIRAALCSEPYMAQMSRLHNDANVLCLGERVVGLELAKSIVDAWLGTQFE 128
PTZ00215 PTZ00215
ribose 5-phosphate isomerase; Provisional
 1-134 1.26e-20

ribose 5-phosphate isomerase; Provisional


Pssm-ID: 185516  Cd Length: 151  Bit Score: 83.14  E-value: 1.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556268249   1 MKTKIAIASDDVGFERKEEIKKYLveeKGAQVVYDPVKCkedGVNNFARL-----ADEMAGVIQRDECRLGIYICGTGIG 75
Cdd:PTZ00215   1 MQKKVAIGSDHAGFDLKNEIIDYI---KNKGKEYKIEDM---GTYTAESVdypdfAEKVCEEVLKGEADTGILVCGSGIG 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 556268249  76 FTCQVNKHWGIRAVAVTNPYSAKRARLSNNAQVIGLGCRVNDLEYTKMIVDAWFDNPFD 134
Cdd:PTZ00215  75 ISIAANKVKGIRCALCHDHYTARMSRQHNNANVLAFGGRTTGIEVAKEIIDTFLSTPFE 133
RPI_actino TIGR02133
ribose 5-phosphate isomerase; This family is a member of the RpiB/LacA/LacB subfamily ...
 4-139 1.41e-20

ribose 5-phosphate isomerase; This family is a member of the RpiB/LacA/LacB subfamily (TIGR00689) but lies outside the RpiB equivalog (TIGR01120) which is also a member of that subfamily. Ribose 5-phosphate isomerase is an essential enzyme of the pentose phosphate pathway; a pathway that appears to be present in the actinobacteria. The only candidates for ribose 5-phosphate isomerase in the Actinobacteria are members of this family.


Pssm-ID: 273989  Cd Length: 148  Bit Score: 82.89  E-value: 1.41e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556268249    4 KIAIASDDVGFERKEEIKKYLVEEkGAQVVyDPVKCKEDGVNNFARLADEMAGVIQRDECRLGIYICGTGIGFTCQVNKH 83
Cdd:TIGR02133   2 RVVLGHDHAGFEYKEALWLDLAAH-EPEVC-DVGVYDADDDDDYPCFCIAAAEAVARDAADLGIVIGGSGNGEAIAANKV 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 556268249   84 WGIRAVAVTNPYSAKRARLSNNAQVIGLGCRVNDLEYTKMIVDAWFDNPFDFATAR 139
Cdd:TIGR02133  80 KGARAALAWDTASAGRARLHNNANVVGAGMRMHGLEEAFRLVFEFLGFEFDARSRH 135
PRK08621 PRK08621
galactose-6-phosphate isomerase subunit LacA; Reviewed
 4-134 9.73e-14

galactose-6-phosphate isomerase subunit LacA; Reviewed


Pssm-ID: 181505  Cd Length: 142  Bit Score: 64.73  E-value: 9.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556268249   4 KIAIASDDVGFERKEEIKKYLVEEKgaqvvYDPVKCKEDGVNNFARLADEMAGVIQRDECRLGIYICGTGIGFTCQVNKH 83
Cdd:PRK08621   2 AIIIGADKAGFELKEVVKDYLEDNK-----YEVVDVTEEGAEDFVDSTLAVAKEVNKSEDNLGIVIDAYGAGSFMVATKI 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 556268249  84 WGIRAVAVTNPYSAKRARLSNNAQVIGLGCRVNDLEYTKMIVDAWFDNPFD 134
Cdd:PRK08621  77 KGMVAAEVSDERSAYMTRGHNNARMITMGSEIVGDGLAKNIIKGFVEGKYD 127
PRK08622 PRK08622
galactose-6-phosphate isomerase subunit LacB; Reviewed
 3-133 2.32e-13

galactose-6-phosphate isomerase subunit LacB; Reviewed


Pssm-ID: 181506  Cd Length: 171  Bit Score: 64.28  E-value: 2.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556268249   3 TKIAIASDDVGFERKEEIKKYLvEEKGAQVV----YDPVKckedgvNNFARLADEMAGVIQRDECRLGIYICGTGIGFTC 78
Cdd:PRK08622   1 MKIAIGCDHIVTDEKMAVSDYL-KSKGHEVIdvgtYDFTR------THYPIFGKKVGEAVASGEADLGVCICGTGVGISN 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 556268249  79 QVNKHWGIRAVAVTNPYSAKRARLSNNAQVIGLGCRVNDLEYTKMIVDAWFDNPF 133
Cdd:PRK08622  74 AVNKVPGIRSALVRDMTSALYAKEELNANVIGFGGKITGELLMCDIIDAFINAEY 128
PRK12615 PRK12615
galactose-6-phosphate isomerase subunit LacB; Reviewed
 4-143 5.16e-09

galactose-6-phosphate isomerase subunit LacB; Reviewed


Pssm-ID: 171610  Cd Length: 171  Bit Score: 52.72  E-value: 5.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556268249   4 KIAIASDDVGFERKEEIKKYLvEEKGAQVV----YDPVKckedgvNNFARLADEMAGVIQRDECRLGIYICGTGIGFTCQ 79
Cdd:PRK12615   2 KIAIGCDHIVTNEKMAVSDFL-KSKGYDVIdcgtYDHTR------THYPIFGKKVGEAVVNGQADLGVCICGTGVGINNA 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556268249  80 VNKHWGIRAVAVTNPYSAKRARLSNNAQVIGLGCRVNDLEYTKMIVDAWFDNpfDFATARENSK 143
Cdd:PRK12615  75 VNKVPGIRSALVRDMTTALYAKEELNANVIGFGGKITGELLMCDIIDAFIKA--EYKETEENKK 136
PRK12613 PRK12613
galactose-6-phosphate isomerase subunit LacA; Provisional
 5-134 2.31e-08

galactose-6-phosphate isomerase subunit LacA; Provisional


Pssm-ID: 171609  Cd Length: 141  Bit Score: 50.31  E-value: 2.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556268249   5 IAIASDDVGFERKEEIKKYLVEEkgAQVVYDPVKCKEDGVNNfaRLAdeMAGVIQRDECRLGIYICGTGIGFTCQVNKHW 84
Cdd:PRK12613   3 IILGADAHGNALKELIKSFLQEE--GYDIIDVTDINSDFIDN--TLA--VAKAVNEAEGRLGIMVDAYGAGPFMVATKLK 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 556268249  85 GIRAVAVTNPYSAKRARLSNNAQVIGLGCRVNDLEYTKMIVDAWFDNPFD 134
Cdd:PRK12613  77 GMVAAEVSDERSAYMTRGHNNARMITMGAEIVGPELAKNIAKGFVTGPYD 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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