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Conserved domains on  [gi|556278204|ref|WP_023288784|]
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MULTISPECIES: isochorismate synthase EntC [Klebsiella]

Protein Classification

isochorismate synthase EntC( domain architecture ID 11487569)

isochorismate synthase EntC catalyzes the reversible conversion of chorismate to isochorismate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15016 PRK15016
isochorismate synthase EntC; Provisional
 1-391 0e+00

isochorismate synthase EntC; Provisional


:

Pssm-ID: 184977 [Multi-domain]  Cd Length: 391  Bit Score: 778.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204   1 METSLAEDVQKSTRTLSPDSFFFMSPYRSFSTSGCFRRFSSPADGGDALNGEFQQQMAAAFAEARAAGIRKPVMVGAIPF 80
Cdd:PRK15016   1 MDTSLAEEVQQTMATLAPDRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  81 DTCQPSELYIPERWEAFSRPEKQRSARYAAPLETMEVVERREIPEQDAFLAMVERAAALTATPEVDKVVLSRLIDITTRD 160
Cdd:PRK15016  81 DTRQPSSLYIPESWQSFSRQEKQRSARRFTRSQSLNVVERQAIPEQTTFEAMVARAAALTATPQVDKVVLSRLIDITTDA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 161 PVDSGALMERLIAQNPASFNFHVPLSDGGVLLGASPELLLRKEGPHFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRH 240
Cdd:PRK15016 161 AIDSGALLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSLPLAGSARRQPDEVLDREAGNRLLASEKDRH 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 241 EHELVTQAMKSVLGPRSSQLSLPASPQLITTPTLWHLATPIEGTALAEENAMSLACLLHPTPALSGFPHQAAKRLIADLE 320
Cdd:PRK15016 241 EHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANAQENALTLACLLHPTPALSGFPHQAAKQVIAELE 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556278204 321 PFDRQLFGGIVGWCDDEGNGEWVVTIRCARLQQRTLRLFAGAGIVPASSPLGEWRETGVKLTTMLNVFGLN 391
Cdd:PRK15016 321 PFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGLH 391
 
Name Accession Description Interval E-value
PRK15016 PRK15016
isochorismate synthase EntC; Provisional
 1-391 0e+00

isochorismate synthase EntC; Provisional


Pssm-ID: 184977 [Multi-domain]  Cd Length: 391  Bit Score: 778.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204   1 METSLAEDVQKSTRTLSPDSFFFMSPYRSFSTSGCFRRFSSPADGGDALNGEFQQQMAAAFAEARAAGIRKPVMVGAIPF 80
Cdd:PRK15016   1 MDTSLAEEVQQTMATLAPDRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  81 DTCQPSELYIPERWEAFSRPEKQRSARYAAPLETMEVVERREIPEQDAFLAMVERAAALTATPEVDKVVLSRLIDITTRD 160
Cdd:PRK15016  81 DTRQPSSLYIPESWQSFSRQEKQRSARRFTRSQSLNVVERQAIPEQTTFEAMVARAAALTATPQVDKVVLSRLIDITTDA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 161 PVDSGALMERLIAQNPASFNFHVPLSDGGVLLGASPELLLRKEGPHFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRH 240
Cdd:PRK15016 161 AIDSGALLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSLPLAGSARRQPDEVLDREAGNRLLASEKDRH 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 241 EHELVTQAMKSVLGPRSSQLSLPASPQLITTPTLWHLATPIEGTALAEENAMSLACLLHPTPALSGFPHQAAKRLIADLE 320
Cdd:PRK15016 241 EHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANAQENALTLACLLHPTPALSGFPHQAAKQVIAELE 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556278204 321 PFDRQLFGGIVGWCDDEGNGEWVVTIRCARLQQRTLRLFAGAGIVPASSPLGEWRETGVKLTTMLNVFGLN 391
Cdd:PRK15016 321 PFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGLH 391
MenF COG1169
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites ...
 19-391 1.69e-141

Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; Isochorismate synthase EntC is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440783 [Multi-domain]  Cd Length: 353  Bit Score: 406.46  E-value: 1.69e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  19 DSFFFMSPYRSFS--TSGCFRRFSSPADGGDAlngEFQQQMAAAFAEARAAGIRkPVMVGAIPFDTCQP---SELYIPEr 93
Cdd:COG1169    1 PRFYWASPDRGEGlaGLGEAARFEAPGPDRFA---ALAAAWQALLADAALAGTG-PRAFGGFAFDPDSPapaARLVLPR- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  94 weafsrpekqrsaryaapleTMEVVERREIPEQDAFLAMVERAAALTATPEVDKVVLSRLIDITTRDPVDSGALMERLIA 173
Cdd:COG1169   76 --------------------LLLRRSRRGVPDPAEWREAVAQALEAIRAGELDKVVLARALDLTLDEPIDPRALLARLRR 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 174 QNPASFNFHVPLSDGGVLLGASPELLLRKEGPHFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHEHELVTQAMKSVL 253
Cdd:COG1169  136 RNPDCYTFAVELGAGDGFVGASPERLVRRRGGQLTTEALAGTAPRGADPEEDAALAAALLASEKDRREHALVVDSIREAL 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 254 GPRSSQLSLPASPQLITTPTLWHLATPIEGTALAEENAMSLACLLHPTPALSGFPHQAAKRLIADLEPFDRQLFGGIVGW 333
Cdd:COG1169  216 APLCSSLDVPEEPELLRLRNVQHLATPITGTLDPGVSALDLAAALHPTPAVGGTPREAALALIRELEPFDRGWYAGPVGW 295

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 556278204 334 CDDEGNGEWVVTIRCARLQQRTLRLFAGAGIVPASSPLGEWRETGVKLTTMLNVFGLN 391
Cdd:COG1169  296 VDADGDGEFAVAIRSALIDGNRARLFAGAGIVAGSDPEAEWAETEAKLRTMLRALGLE 353
Chorismate_bind pfam00425
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ...
 127-380 2.27e-91

chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.


Pssm-ID: 425674 [Multi-domain]  Cd Length: 255  Bit Score: 275.20  E-value: 2.27e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  127 DAFLAMVERAAALTATPEVDKVVLSRLIDITTRDPVDSGALMERLIAQNPASFNFHVPLsDGGVLLGASPELLLRKEGPH 206
Cdd:pfam00425   1 EDYLAAVEKAKEAIRAGDLYKVVLSRRLTLPLAGDIDPLALYRRLRARNPAPYSFYFRT-GDFTFLGASPERLLSVDGGR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  207 FSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHEHELVTQAMKSVLGP--RSSQLSLPASPQLITTPTLWHLATPIEGT 284
Cdd:pfam00425  80 IITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRvcVPGSVKVPELPEVERYGTVQHLVSTISGR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  285 ALAEENAMSLACLLHPTPALSGFPHQAAKRLIADLEPFDRQLFGGIVGWCDDEGNGEWVVTIRCARLQQRTLRLFAGAGI 364
Cdd:pfam00425 160 LKPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAGI 239

                         250
                  ....*....|....*.
gi 556278204  365 VPASSPLGEWRETGVK 380
Cdd:pfam00425 240 VADSDPEAEWEETEAK 255
isochor_syn TIGR00543
isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, ...
 72-388 1.58e-84

isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273127  Cd Length: 351  Bit Score: 261.15  E-value: 1.58e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204   72 PVMVGAIPFDTCQPSE--------LYIPE------------RWEAFSRPEKQRSARYAAPL--------------ETMEV 117
Cdd:TIGR00543   1 PRLFGGFPFDPEEPAAweefgegyFVLPEvlvesdgggtllTCTIVAEPELNEADLLLYAKfavssgirplralpEQMTT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  118 VERREIPEQDAFLAMVERAAALTATPEVDKVVLSRLIDITTRDPVDSGALMERLIAQNPASFNFHVPLSDGGVLLGASPE 197
Cdd:TIGR00543  81 LTTGEDPDKAAWRTAVEEALENIRQGPLDKVVLARALTLKFADDIDPIAVLANLRQQYPNAYIFLLEPPQGGVFLGATPE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  198 LLLRKEGPHFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHEHELVTQAMKSVLGPRSSQLSLPASPQLITTPTLWHL 277
Cdd:TIGR00543 161 RLLSREKGELLTEALAGTAPRSADPEEDRKLGELLLKDDKNLREHRLVVEYIRRRLQPICTSLDVSETPELLKLANVQHL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  278 ATPIEGTALAEENAMSLACLLHPTPALSGFPHQAAKRLIADLEPFDRQLFGGIVGWCDDEGNGEWVVTIRCARLQQRTLR 357
Cdd:TIGR00543 241 YTPISARLKDGDSLLDLLKQLHPTPAVGGLPREEALDFIREHEPFDRGLYAAPLGWLDGEGNGEFAVGIRSALVEDGQVR 320

                         330       340       350
                  ....*....|....*....|....*....|.
gi 556278204  358 LFAGAGIVPASSPLGEWRETGVKLTTMLNVF 388
Cdd:TIGR00543 321 LYAGAGIVADSDPESEWEETELKLQTMLRAL 351
 
Name Accession Description Interval E-value
PRK15016 PRK15016
isochorismate synthase EntC; Provisional
 1-391 0e+00

isochorismate synthase EntC; Provisional


Pssm-ID: 184977 [Multi-domain]  Cd Length: 391  Bit Score: 778.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204   1 METSLAEDVQKSTRTLSPDSFFFMSPYRSFSTSGCFRRFSSPADGGDALNGEFQQQMAAAFAEARAAGIRKPVMVGAIPF 80
Cdd:PRK15016   1 MDTSLAEEVQQTMATLAPDRFFFMSPYRSFTTSGCFARFDEPAVNGDSPDSPFQQKLAALFADAKAQGIKNPVMVGAIPF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  81 DTCQPSELYIPERWEAFSRPEKQRSARYAAPLETMEVVERREIPEQDAFLAMVERAAALTATPEVDKVVLSRLIDITTRD 160
Cdd:PRK15016  81 DTRQPSSLYIPESWQSFSRQEKQRSARRFTRSQSLNVVERQAIPEQTTFEAMVARAAALTATPQVDKVVLSRLIDITTDA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 161 PVDSGALMERLIAQNPASFNFHVPLSDGGVLLGASPELLLRKEGPHFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRH 240
Cdd:PRK15016 161 AIDSGALLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSLPLAGSARRQPDEVLDREAGNRLLASEKDRH 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 241 EHELVTQAMKSVLGPRSSQLSLPASPQLITTPTLWHLATPIEGTALAEENAMSLACLLHPTPALSGFPHQAAKRLIADLE 320
Cdd:PRK15016 241 EHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANAQENALTLACLLHPTPALSGFPHQAAKQVIAELE 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556278204 321 PFDRQLFGGIVGWCDDEGNGEWVVTIRCARLQQRTLRLFAGAGIVPASSPLGEWRETGVKLTTMLNVFGLN 391
Cdd:PRK15016 321 PFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGLH 391
MenF COG1169
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites ...
 19-391 1.69e-141

Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; Isochorismate synthase EntC is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440783 [Multi-domain]  Cd Length: 353  Bit Score: 406.46  E-value: 1.69e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  19 DSFFFMSPYRSFS--TSGCFRRFSSPADGGDAlngEFQQQMAAAFAEARAAGIRkPVMVGAIPFDTCQP---SELYIPEr 93
Cdd:COG1169    1 PRFYWASPDRGEGlaGLGEAARFEAPGPDRFA---ALAAAWQALLADAALAGTG-PRAFGGFAFDPDSPapaARLVLPR- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  94 weafsrpekqrsaryaapleTMEVVERREIPEQDAFLAMVERAAALTATPEVDKVVLSRLIDITTRDPVDSGALMERLIA 173
Cdd:COG1169   76 --------------------LLLRRSRRGVPDPAEWREAVAQALEAIRAGELDKVVLARALDLTLDEPIDPRALLARLRR 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 174 QNPASFNFHVPLSDGGVLLGASPELLLRKEGPHFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHEHELVTQAMKSVL 253
Cdd:COG1169  136 RNPDCYTFAVELGAGDGFVGASPERLVRRRGGQLTTEALAGTAPRGADPEEDAALAAALLASEKDRREHALVVDSIREAL 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 254 GPRSSQLSLPASPQLITTPTLWHLATPIEGTALAEENAMSLACLLHPTPALSGFPHQAAKRLIADLEPFDRQLFGGIVGW 333
Cdd:COG1169  216 APLCSSLDVPEEPELLRLRNVQHLATPITGTLDPGVSALDLAAALHPTPAVGGTPREAALALIRELEPFDRGWYAGPVGW 295

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 556278204 334 CDDEGNGEWVVTIRCARLQQRTLRLFAGAGIVPASSPLGEWRETGVKLTTMLNVFGLN 391
Cdd:COG1169  296 VDADGDGEFAVAIRSALIDGNRARLFAGAGIVAGSDPEAEWAETEAKLRTMLRALGLE 353
PRK06923 PRK06923
isochorismate synthase DhbC; Validated
 18-391 6.35e-103

isochorismate synthase DhbC; Validated


Pssm-ID: 235886 [Multi-domain]  Cd Length: 399  Bit Score: 310.13  E-value: 6.35e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  18 PDSFFFMSPYRSFSTSGCFRrfSSPADGGDALNGEFQQQMAAAFAEaraaGIRKPVMVGAIPFDTCQPSELYIPE----- 92
Cdd:PRK06923  21 ESSFFFASPTRTILAEGEFT--TVKHHEIESFPERVQAVLRNAKQA----GNPNPIVVGALPFDRRKEVQLIVPEysris 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  93 ---RWEAFSRPEKQRSARYaapletmevvERREIPEQDAFLAMVERAAALTATPEVDKVVLSRLIDITTRDPVDSGALME 169
Cdd:PRK06923  95 erlQLDTTNHLEINRNLTF----------EMTPVPDPEVYMNGVKQGIAKIQDGDLKKIVLSRSLDVKSSEKIDKQKLLR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 170 RLIAQNPASFNFHVPLSDG-----GVLLGASPELLLRKEGPHFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHEHEL 244
Cdd:PRK06923 165 ELAEHNKHGYTFAVNLPKDenensKTLIGASPELLVSRHGMQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKDLHEHAV 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 245 VTQAMKSVLGPRSSQLSLPASPQLITTPTLWHLATPIEGTaLAEEN--AMSLACLLHPTPALSGFPHQAAKRLIADLEPF 322
Cdd:PRK06923 245 VVEAVAAALRPYCHTLHVPEKPSVIHTEAMWHLSTEVKGE-LKDPNtsSLELAIALHPTPAVCGTPTEEAREAIQQIEPF 323

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556278204 323 DRQLFGGIVGWCDDEGNGEWVVTIRCARLQQRTLRLFAGAGIVPASSPLGEWRETGVKLTTMLNVFGLN 391
Cdd:PRK06923 324 DREFFTGMLGWSDLNGDGEWIVTIRCAEVEENTLRLYAGAGVVAESKPEDELAETSAKFQTMLKAMGLN 392
Chorismate_bind pfam00425
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ...
 127-380 2.27e-91

chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.


Pssm-ID: 425674 [Multi-domain]  Cd Length: 255  Bit Score: 275.20  E-value: 2.27e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  127 DAFLAMVERAAALTATPEVDKVVLSRLIDITTRDPVDSGALMERLIAQNPASFNFHVPLsDGGVLLGASPELLLRKEGPH 206
Cdd:pfam00425   1 EDYLAAVEKAKEAIRAGDLYKVVLSRRLTLPLAGDIDPLALYRRLRARNPAPYSFYFRT-GDFTFLGASPERLLSVDGGR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  207 FSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHEHELVTQAMKSVLGP--RSSQLSLPASPQLITTPTLWHLATPIEGT 284
Cdd:pfam00425  80 IITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRvcVPGSVKVPELPEVERYGTVQHLVSTISGR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  285 ALAEENAMSLACLLHPTPALSGFPHQAAKRLIADLEPFDRQLFGGIVGWCDDEGNGEWVVTIRCARLQQRTLRLFAGAGI 364
Cdd:pfam00425 160 LKPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAGI 239

                         250
                  ....*....|....*.
gi 556278204  365 VPASSPLGEWRETGVK 380
Cdd:pfam00425 240 VADSDPEAEWEETEAK 255
isochor_syn TIGR00543
isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, ...
 72-388 1.58e-84

isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273127  Cd Length: 351  Bit Score: 261.15  E-value: 1.58e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204   72 PVMVGAIPFDTCQPSE--------LYIPE------------RWEAFSRPEKQRSARYAAPL--------------ETMEV 117
Cdd:TIGR00543   1 PRLFGGFPFDPEEPAAweefgegyFVLPEvlvesdgggtllTCTIVAEPELNEADLLLYAKfavssgirplralpEQMTT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  118 VERREIPEQDAFLAMVERAAALTATPEVDKVVLSRLIDITTRDPVDSGALMERLIAQNPASFNFHVPLSDGGVLLGASPE 197
Cdd:TIGR00543  81 LTTGEDPDKAAWRTAVEEALENIRQGPLDKVVLARALTLKFADDIDPIAVLANLRQQYPNAYIFLLEPPQGGVFLGATPE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  198 LLLRKEGPHFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHEHELVTQAMKSVLGPRSSQLSLPASPQLITTPTLWHL 277
Cdd:TIGR00543 161 RLLSREKGELLTEALAGTAPRSADPEEDRKLGELLLKDDKNLREHRLVVEYIRRRLQPICTSLDVSETPELLKLANVQHL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  278 ATPIEGTALAEENAMSLACLLHPTPALSGFPHQAAKRLIADLEPFDRQLFGGIVGWCDDEGNGEWVVTIRCARLQQRTLR 357
Cdd:TIGR00543 241 YTPISARLKDGDSLLDLLKQLHPTPAVGGLPREEALDFIREHEPFDRGLYAAPLGWLDGEGNGEFAVGIRSALVEDGQVR 320

                         330       340       350
                  ....*....|....*....|....*....|.
gi 556278204  358 LFAGAGIVPASSPLGEWRETGVKLTTMLNVF 388
Cdd:TIGR00543 321 LYAGAGIVADSDPESEWEETELKLQTMLRAL 351
PRK07054 PRK07054
isochorismate synthase;
133-384 3.85e-56

isochorismate synthase;


Pssm-ID: 235920 [Multi-domain]  Cd Length: 475  Bit Score: 191.13  E-value: 3.85e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 133 VERAAALTATPEVDKVVLSRLIDITTRDPVDSGALMERLIAQNPASFNFHVPlSDGGVLLGASPELLLRKEGPHFSSLPL 212
Cdd:PRK07054 201 VRRAVDAIRGGAFGKVVLARDVLQQYARPVAIGPLLRRLRLRDPHAHLFAFR-RGNACFLGATPERLVRVAAGDLHTHAL 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 213 AGSARRQPDDVLDREAGNRLLASGKDRHEHELVTQAMKSVLGPRSSQLSLPASPQLITTPTLWHLATPIEGTALAEENAM 292
Cdd:PRK07054 280 AGTIARGADPAEDARLGAALMASAKDRLEHALVVDAIRAALAPLSRALDIPDQPSLHRLPRLQHLSTPIRATLAPDATLL 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 293 SLACLLHPTPALSGFPHQAAKRLIADLEPFDRQLFGGIVGWCDDEGNGEWVVTIRCARLQQRTLRLFAGAGIVPASSPLG 372
Cdd:PRK07054 360 QVVAALHPTPAVGGHPRAAALDYIRAHEGFDRGWYAAPIGWLDAHGNGDFAVALRSALITGGACRLFAGCGIVADSEPAS 439

                        250
                 ....*....|..
gi 556278204 373 EWRETGVKLTTM 384
Cdd:PRK07054 440 EYRETCLKLSGM 451
PRK15012 PRK15012
menaquinone-specific isochorismate synthase; Provisional
 105-376 1.46e-36

menaquinone-specific isochorismate synthase; Provisional


Pssm-ID: 184974 [Multi-domain]  Cd Length: 431  Bit Score: 137.67  E-value: 1.46e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 105 SARYAAPLETM--EVVERREIPEQDAFLAMVERAAALTATPEVDKVVLSRLIDITTRDPVDSGALMERLIAQNPASFNFH 182
Cdd:PRK15012 146 TLVSIKPLPGLhlTTTREQHWPDKTGWTQLIELATKTIAEGELDKVVLARATDLHFASPVNAAAMMAASRRLNLNCYHFY 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 183 VPLSDGGVLLGASPELLLRKEGPHFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHEHELVTQAMKSVLGPRSSQLS- 261
Cdd:PRK15012 226 MAFDAENAFLGSSPERLWRRRDKALRTEALAGTVANHPDDKQAQQLGEWLMADDKNQRENMLVVEDICQRLQADTQTLDv 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 262 LPasPQLITTPTLWHLATPIeGTALAEENAMSLACLLHPTPALSGFPHQAAKRLIADLEPFDRQLFGGIVGWCDDEgNGE 341
Cdd:PRK15012 306 LP--PQVLRLRKVQHLRRCI-WTSLNKADDVICLHQLQPTAAVAGLPRDLARQFIARHEPFTREWYAGSAGYLSLQ-QSE 381

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 556278204 342 WVVTIRCARLQQRTLRLFAGAGIVPASSPLGEWRE 376
Cdd:PRK15012 382 FCVSLRSAKVSGNVVRLYAGAGIVRGSDPEQEWQE 416
PLN02786 PLN02786
isochorismate synthase
 117-380 1.37e-34

isochorismate synthase


Pssm-ID: 178383 [Multi-domain]  Cd Length: 533  Bit Score: 134.14  E-value: 1.37e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 117 VVERREIPEQDAFLAMVERAAAL--TATPEVDKVVLSRLIDITTRDPVDSGALMERLIAQNPASFNFHVPLSDGGVLLGA 194
Cdd:PLN02786 250 VLSKNHVPSKGAWHLAVNKALQIikRKSSPLKKVVLARSSRIITDTDIDPIAWLACLQVEGQNAYQFCLQPPDAPAFIGN 329

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 195 SPELLLRKEGPHFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHEHELVTQAMKSVLGPRSSQLSLPASPQLITTPTL 274
Cdd:PLN02786 330 TPEQLFHRKGLGVCSEALAATRPRGGSSARDLQIELDLLTSPKDDLEFSIVRENIREKLEAICDRVVVEPHKAIRKLARV 409

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 275 WHLATPIEGTALAEENAMSLACLLHPTPALSGFPHQAAKRLIADLEPFDRQLFGGIVGWCDDEGNgEWVVTIRCARLQQ- 353
Cdd:PLN02786 410 QHLYAQLAGRLRSEDDEFDILAALHPTPAVCGHPTEEARLLIAETESFDRGMYAGPVGWFGGGES-EFAVGIRSALVEKg 488

                        250       260
                 ....*....|....*....|....*..
gi 556278204 354 RTLRLFAGAGIVPASSPLGEWRETGVK 380
Cdd:PLN02786 489 LGALIYAGTGIVEGSNPSSEWNELELK 515
TrpE COG0147
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ...
 126-390 3.17e-28

Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439917 [Multi-domain]  Cd Length: 416  Bit Score: 114.43  E-value: 3.17e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 126 QDAFLAMVERA-AALTATpEVDKVVLSRLIDITTrdPVDSGALMERLIAQNPASFNFHVPLsDGGVLLGASPELLLRKEG 204
Cdd:COG0147  153 REEYLAAVERAkEYIRAG-DIFQVVLSQRFSAPF--EGDPLALYRALRRINPSPYMFYLRF-GDFAIVGSSPERLVRVED 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 205 PHFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHEHelvtqAMkSV------LGpRSSQlslPAS---PQLITT---P 272
Cdd:COG0147  229 GRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEH-----LM-LVdlarndLG-RVCE---PGSvkvPELMVVeryS 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 273 TLWHLATPIEGTALAEENAMSL--ACLlhptPA--LSGFPHQAAKRLIADLEPFDRQLFGGIVGWCDDEGNGEWVVTIRC 348
Cdd:COG0147  299 HVMHLVSTVTGRLRPGLDALDAlrATF----PAgtLTGAPKIRAMEIIDELEPTRRGVYGGAVGYLSFDGNMDLAIAIRT 374

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 556278204 349 ARLQQRTLRLFAGAGIVPASSPLGEWRETGVKLTTMLNVFGL 390
Cdd:COG0147  375 AVVKDGRAYVQAGAGIVADSDPEAEYQETLNKARALLRALEL 416
PRK13572 PRK13572
anthranilate synthase component I; Provisional
 111-390 3.18e-25

anthranilate synthase component I; Provisional


Pssm-ID: 237432 [Multi-domain]  Cd Length: 435  Bit Score: 106.36  E-value: 3.18e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 111 PLETMEVVERREIPEQDA-------------FLAMVERAAALTATPEVDKVVLSRLIDITTR-DPVDsgaLMERLIAQNP 176
Cdd:PRK13572 144 AEKIVEKAKRFEIEEEDGgsevlgcdadreeFVEMVEKAKEYIYSGDVFQVVLSREYRLKTDlSPFQ---LYRNLREINP 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 177 ASFNFhvPLSDGGVLLGASPELLLRKEGPHFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHEH----ELVTQAMKSV 252
Cdd:PRK13572 221 SPYMF--LLEFDKDVVGASPETMASVENNILKINPIAGTAPRGKTEEEDKKLAEALLSDEKERAEHvmlvDLARNDVRKV 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 253 LGPRSSQLSlpASPQLITTPTLWHLATPIEGTaLAEE----NAMSLAcllHPTPALSGFPHQAAKRLIADLEPFDRQLFG 328
Cdd:PRK13572 299 SKSGSVRLE--RFFDVVKYSHVQHIESEVVGE-LKEDstmfDAIEAA---FPAGTLTGAPKFRAMEIIDELEKSRRKVYG 372

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556278204 329 GIVGWCDDEGNGEWVVTIRCARLQqRTLRLFAGAGIVPASSPLGEWRETGVKLTTMLNVFGL 390
Cdd:PRK13572 373 GAVGYFSNSGNADLAIAIRMAEID-KVCRVRAGAGIVADSVPEKEFYETERKMAAVLKALGV 433
PRK13574 PRK13574
anthranilate synthase component I; Provisional
 147-381 2.50e-24

anthranilate synthase component I; Provisional


Pssm-ID: 184155 [Multi-domain]  Cd Length: 420  Bit Score: 103.36  E-value: 2.50e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 147 KVVLSRLIDITTRdpvdsGALME---RLIAQNPASFNFHVPLSDGGVLlGASPELLLRKEGPHFSSLPLAGSARRQPDDV 223
Cdd:PRK13574 178 QVVLSRFYRYLFS-----GDPLRiyyNLRRINPSPYMFYLKFDERYLI-GSSPELLFRVQDNIVETYPIAGTRPRGSDQE 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 224 LDREAGNRLLASGKDRHEHELVTQAMKSVLGprssQLSLPAS---PQLITTPT---LWHLATPIEGTALAEENAMSLACL 297
Cdd:PRK13574 252 EDLKLELELMNSEKDKAEHLMLVDLARNDLG----KVCVPGTvrvPELMYVEKyshVQHIVSKVIGTLKKKYNALDVLKA 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 298 LHPTPALSGFPHQAAKRLIADLEPFDRQLFGGIVGWCDDEGNGEWVVTIRCARLQQRTLRLFAGAGIVPASSPLGEWRET 377
Cdd:PRK13574 328 TFPAGTVSGAPKPMAMNIIETLEEYKRGPYAGAVGFISADGNAEFAIAIRTAFLNKDLLRIQAGAGIVYDSNPESEYFET 407


                 ....
gi 556278204 378 GVKL 381
Cdd:PRK13574 408 EHKL 411
PRK13571 PRK13571
anthranilate synthase component I; Provisional
 106-386 8.66e-22

anthranilate synthase component I; Provisional


Pssm-ID: 184152 [Multi-domain]  Cd Length: 506  Bit Score: 97.02  E-value: 8.66e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 106 ARYAAPLETMEVVERREIPE------QDAFLAMVERAAALTATPEVDKVVLSRLIDI-TTRDPVDsgaLMERLIAQNPAS 178
Cdd:PRK13571 203 AALAQPLPSTVATFSRPVPEfraqrtVEEFGAAVEKLVEEIRAGEAFQVVPSQRFEMdTTADPLD---VYRVLRVTNPSP 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 179 FNF--HVPLSDGGV---LLGASPELLLRKEGPHFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHEHELVTQAMKSVL 253
Cdd:PRK13571 280 YMYllRVPNSDGGTdfsIVGSSPEALVTVTDGRATTHPIAGTRWRGATPEEDALLEKELLADPKERAEHLMLVDLGRNDL 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 254 GprssQLSLPASPQLITTPTL------WHLATPIEGTALAEENAMS--LACLlhPTPALSGFPHQAAKRLIADLEPFDRQ 325
Cdd:PRK13571 360 G----RVCRPGTVRVVDFSHIeryshvMHLVSTVTGELAEGRTALDavTACF--PAGTLSGAPKVRAMELIEELEPTRRG 433

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556278204 326 LFGGIVGWCDDEGNGEWVVTIRCARLQQRTLRLFAGAGIVPASSPLGEWRETGVKLTTMLN 386
Cdd:PRK13571 434 LYGGVVGYLDFAGDADTAIAIRTALMRDGTAYVQAGGGVVADSDPDYEDNEARNKAAAVLR 494
PRK09070 PRK09070
aminodeoxychorismate synthase component I;
92-390 5.58e-19

aminodeoxychorismate synthase component I;


Pssm-ID: 236371 [Multi-domain]  Cd Length: 447  Bit Score: 88.22  E-value: 5.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  92 ERWEAFSRPEKQRSARYAAPLETMEVVERREIPEQdaFLAMVERAAALTATPEVDKVVLSRLIDITTRDPVDSGALMERL 171
Cdd:PRK09070 150 HLLDQIEADLAACAALPPLPVWLAPQAVEEDPPER--FTDGVERVLDYIRAGDVFQVNLSRAWQAQFANAVDPAALYARL 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 172 IAQNPASFNFHVPLSDGGVlLGASPELLLRKEGPHFSSLPLAGSARRQPDDVlDREAGNRLLASGKDRHEHELVTQAMKS 251
Cdd:PRK09070 228 RAANPAPFSGLFVAAGRAI-VSSSPERLVSVQGGVVQTRPIAGTRPRFAGDD-DAALIRELVGHPKERAEHVMLIDLERN 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 252 VLGprssQLSLPASPQ------LITTPTLWHLATPIEGTALAEENAMSLACLLHPTPALSGFPHQAAKRLIADLEPFDRQ 325
Cdd:PRK09070 306 DLG----RICAPGSVEvdelmtVESYAHVHHIVSNVRGRLRDGVTPGEVIRAVFPGGTITGCPKVRCMQIIAELEQTPRG 381

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556278204 326 LFGGIVGWCDDEGNGEWVVTIRCARLQQRTLRLFAGAGIVPASSPLGEWRETGVKLTTMLNVFGL 390
Cdd:PRK09070 382 AYTGSFGYLNRDGDMDLNILIRTAEVQGNQVRFRTGAGIVVDSDPERELDETRAKARGLLRALEQ 446
PRK07508 PRK07508
aminodeoxychorismate synthase component I;
163-376 8.81e-17

aminodeoxychorismate synthase component I;


Pssm-ID: 236035 [Multi-domain]  Cd Length: 378  Bit Score: 81.21  E-value: 8.81e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 163 DSGALMERLIAQNPASFNFHVPLsDGGVLLGASPELLLRKEGP-HFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHE 241
Cdd:PRK07508 146 DPLALFWALAARQPVGYGALVDL-GGPVILSRSPELFFRVDGEgWIETHPMKGTAPRGATPAEDARLRAALLNDEKNQAE 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 242 HELVTQAMKSVLgprsSQLSLPAS---PQLI---TTPTLWHLATPIEGTALAEenaMSLACLLH---PTPALSGFPHQAA 312
Cdd:PRK07508 225 NRMIVDLLRNDI----SRISEVGSldvPELFdieTYPTVHQMVSRVRARLLPG---LGLADIFAalfPCGSITGAPKIRA 297

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556278204 313 KRLIADLEPFDRQLFGGIVGWCDDEGNGEWVVTIrcarlqqRTLRLFA--------GAGIVPASSPLGEWRE 376
Cdd:PRK07508 298 MEILRELEPGPRDLYCGAIGWIAPDGRMRFNVAI-------RTLSLFPggravfnvGGGIVFDSTAEAEYEE 362
pabB PRK15465
aminodeoxychorismate synthase component 1;
169-385 7.54e-16

aminodeoxychorismate synthase component 1;


Pssm-ID: 185362 [Multi-domain]  Cd Length: 453  Bit Score: 78.81  E-value: 7.54e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 169 ERLIAQNPASFNFHVPLSDGGVLlGASPELLLRKEGPHFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHEHELVTQA 248
Cdd:PRK15465 231 LQLNQANRAPFSAFLRLEQGAIL-SLSPERFILCDNSEIQTRPIKGTLPRLPDPQEDSKQAEKLANSAKDRAENLMIVDL 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 249 MKSVLGprssQLSLPAS---PQLITT---PTLWHLATPIEGTALAEENAMSLACLLHPTPALSGFPHQAAKRLIADLEPF 322
Cdd:PRK15465 310 MRNDIG----RVAVAGSvkvPELFVVepfPAVHHLVSTITARLPEQLHASDLLRAAFPGGSITGAPKVRAMEIIDELEPQ 385

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556278204 323 DRQLFGGIVGWCDDEGNGEWVVTIRCARLQQRTLRLFAGAGIVPASSPLGEWRETGVKLTTML 385
Cdd:PRK15465 386 RRNAWCGSIGYLSFCGNMDTSITIRTLTAINGQIYCSAGGGIVADSQEEAEYQETFDKVNRIL 448
PRK05940 PRK05940
anthranilate synthase component I;
126-377 1.39e-15

anthranilate synthase component I;


Pssm-ID: 235651 [Multi-domain]  Cd Length: 463  Bit Score: 77.85  E-value: 1.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 126 QDAFLAMVERAAALTATPEVDKVVLSRLIDITTrdPVDSGALMERLIAQNPASFN--FHVPLsdgGVLLGASPELLLRKE 203
Cdd:PRK05940 189 QQEYEAAVRQAKKYIQAGDIFQANLSLRFQTTT--SADSWQIYRRLQQINPSPFAsyWRTPW---GDVVSCSPERLVQLQ 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 204 GPHFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHEHELVTQAMKSVLGpRSSQLSLPASPQLITTPT---LWHLATP 280
Cdd:PRK05940 264 GNQAQTRPIAGTRPRGKTPAEDQQLAEELLSNIKERAEHIMLVDLERNDLG-RVCQWGSVEVDELLTIERyshVIHLVSN 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 281 IEGTALAEENAMSLACLLHPTPALSGFPHQAAKRLIADLEPFDRQLFGGIVGWCDDEGNGEWVVTIRC---ARLQQRTLR 357
Cdd:PRK05940 343 VVGTLQPNRDAIDLIRALFPGGTITGCPKVRCMEIIEELEPVRRNLFYGSCGYLDQRGNLDLNILIRTllyTPLSRGLST 422

                        250       260
                 ....*....|....*....|..
gi 556278204 358 LFA--GAGIVPASSPLGEWRET 377
Cdd:PRK05940 423 IWGqvGAGIVADSDPEKEWLES 444
PRK06772 PRK06772
salicylate synthase;
127-384 2.90e-13

salicylate synthase;


Pssm-ID: 102546 [Multi-domain]  Cd Length: 434  Bit Score: 70.92  E-value: 2.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 127 DAFLAMVERAAALTATPEVDKVVLSRLIDITTRDPVDSGALMERLIAQNPASFNFHvplSDGGVLLGASPELLLRKEGPH 206
Cdd:PRK06772 173 EAYKQQVARAVAEIRRGEYVKVIVSRAIPLPSRIDMPATLLYGRQANTPVRSFMFR---QEGREALGFSPELVMSVTGNK 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 207 FSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHEHELVTQA----MKSVLGPRSSQLSLPASPQliTTPTLWHLATPIE 282
Cdd:PRK06772 250 VVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEaiaeLEAVCQPGSVVVEDLMSVR--QRGSVQHLGSGVS 327

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 283 GTALAEENAMSLACLLHPTPALSGFPHQAAKRLIADLEPFDRQLFGGIVGWCDDEGNGEWVVTIRCARLQQRTLrLFAGA 362
Cdd:PRK06772 328 GQLAENKDAWDAFTVLFPSITASGIPKNAALNAIMQIEKTPRELYSGAILLLDDTRFDAALVLRSVFQDSQRCW-IQAGA 406

                        250       260
                 ....*....|....*....|..
gi 556278204 363 GIVPASSPLGEWRETGVKLTTM 384
Cdd:PRK06772 407 GIIAQSTPERELTETREKLASI 428
PRK13566 PRK13566
anthranilate synthase component I;
88-385 6.97e-12

anthranilate synthase component I;


Pssm-ID: 237429 [Multi-domain]  Cd Length: 720  Bit Score: 66.86  E-value: 6.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204  88 LYIPERWEAFSRpEKQRSARYA----------------APLETMEVVERREIPEQDA---FLAMVERAAALTATPEVDKV 148
Cdd:PRK13566 187 LYLPDEILVVDH-YAARAWVDRyefavggvsteglpreTAPSPYKPTTARPGFADHApgeYAALVEKAKESFRRGDLFEV 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 149 VLSRLI-DITTRDPVdsgALMERLIAQNPASFNFHVPLSDGGVLLGASPELLLRKEGPHFSSLPLAGSARRQPDDVLDRE 227
Cdd:PRK13566 266 VPGQTFyEPCERSPS---EIFRRLKEINPSPYGFFINLGDGEYLVGASPEMFVRVEGRRVETCPISGTIKRGADAIGDAE 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 228 AGNRLLASGKDrhEHEL-----VTQAMKS---------VLGPRssqlslpaspQLITTPTLWHLATPIEGTALAEENAMS 293
Cdd:PRK13566 343 QIRKLLNSKKD--ESELtmctdVDRNDKSrvcepgsvkVIGRR----------QIEMYSRLIHTVDHVEGRLRPGFDALD 410

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 294 lACLLHpTPA--LSGFPHQAAKRLIADLEPFDRQLFGGIVGWCDDEGNGEWVVTIRCARLQQRTLRLFAGAGIVPASSPL 371
Cdd:PRK13566 411 -AFLTH-AWAvtVTGAPKLWAMQFIEDHERSPRRWYGGAVGMVGFDGDMNTGLTLRTIRIKDGVAEVRVGATLLFDSDPE 488

                        330
                 ....*....|....
gi 556278204 372 GEWRETGVKLTTML 385
Cdd:PRK13566 489 AEEAETELKASALL 502
PRK13567 PRK13567
anthranilate synthase component I; Provisional
 167-387 4.16e-10

anthranilate synthase component I; Provisional


Pssm-ID: 184148 [Multi-domain]  Cd Length: 468  Bit Score: 60.93  E-value: 4.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 167 LMERLIAQNPASFNFHVPLsDGGVLLGASPELLLRKEGPHFSSLPLAGSARRQPDDVLDREAGNRLLASGKDRHEHELVT 246
Cdd:PRK13567 245 LYQNLKRQNPSPYMYYLNI-DQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHRMLV 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 247 QamksvLGPRS-SQLSLPASPQLITTPTL------WHLATPIEGTALAEENAMSLACLLHPTPALSGFPHQAAKRLIADL 319
Cdd:PRK13567 324 D-----LGRNDiHRVSKIGTSKITKLMVIekyehvMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQ 398

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556278204 320 EPFDRQLFGGIVGWCDDEGNGEWVVTIRCARLQQRTLRLFAGAGIVPASSPLGEWRETGVKLTTMLNV 387
Cdd:PRK13567 399 YPHKRGVYSGGVGYINCNHNLDFALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLKAKSLLEV 466
PRK05877 PRK05877
aminodeoxychorismate synthase component I; Provisional
 195-376 1.36e-09

aminodeoxychorismate synthase component I; Provisional


Pssm-ID: 235634 [Multi-domain]  Cd Length: 405  Bit Score: 59.33  E-value: 1.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 195 SPELLLRKEGPHFSSLPLAGSARRQPDdvldreaGNRLLASGKDRHEHELVTQAMKSVLG--PRSSQLSLPASPQLITTP 272
Cdd:PRK05877 207 SPELFLRRRGSVVTSSPIKGTLPLDAD-------PSALRASAKDVAENIMIVDLVRNDLGrvARTGTVTVPELLVVRPAP 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 273 TLWHLATPIEGTALAEENAMSLACLLHPTPALSGFPHQAAKRLIADLEPFDRQLFGGIVGWCDDEGNGEWVVTIRCARLQ 352
Cdd:PRK05877 280 GVWHLVSTVSAQVPDELPMSDLLDATFPPASVTGTPKLRARELISQWEPVRRGIYCGTVGLASPVAGCELNVAIRTVEFD 359

                        170       180
                 ....*....|....*....|....*
gi 556278204 353 -QRTLRLFAGAGIVPASSPLGEWRE 376
Cdd:PRK05877 360 aDGNAVLGVGGGITADSDPDAEWQE 384
PRK06404 PRK06404
anthranilate synthase component I; Reviewed
 144-385 1.39e-09

anthranilate synthase component I; Reviewed


Pssm-ID: 102361 [Multi-domain]  Cd Length: 351  Bit Score: 59.11  E-value: 1.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 144 EVDKVVLSRLIDITtrdpVDSGALMERLIAQNPASFNFHVPLSDGGVLlGASPELLLRKEGPHFSSLPLAGSArrqPDDV 223
Cdd:PRK06404 122 EVLQVVISREFEAN----IDFKEKLSEFINNDRSRYVFYYRFGKYRVV-GSSPENVFTVNGNIINVDPIAGTY---DDKI 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 224 LDreagNRLLASGKDRHEHELVTQAMKSVLGPRSS--QLSLPASPQLITTPTLWHLATPIEGTaLAEENAMSLACLLHPT 301
Cdd:PRK06404 194 LS----NELLNSEKDKLEHRMLLDLARNDLSKFADigTLNVDKVMKIEEFSSVKHLVSQVTAK-FSNASYRDILASMFPA 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 302 PALSGFPHQAAKRLIADLEPFDRQLFGGIVGWCDDeGNGEWVVTIRCARLQQRTLRLFAGAGIVPASSPLGEWRETGVKL 381
Cdd:PRK06404 269 GTVSGSPKERAIEIINKYEETPRGPYGGAIGIISK-GYTDMALVIRTAYSHGNGFRVRAGAGIVKDSDPEDEVNEIYSKA 347


                 ....
gi 556278204 382 TTML 385
Cdd:PRK06404 348 RSVM 351
PRK07912 PRK07912
salicylate synthase;
147-384 2.67e-07

salicylate synthase;


Pssm-ID: 169151 [Multi-domain]  Cd Length: 449  Bit Score: 52.49  E-value: 2.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 147 KVVLSRLIDITTRdpVDSGALMERLIAQNPASFNFHVPLsdGGV-LLGASPELL--LRKEGPhFSSLPLAGSAR--RQPD 221
Cdd:PRK07912 204 KVILSRCVEVPFA--VDFPATYRLGRRHNTPVRSFLLRL--GGIrALGYSPELVtaVRADGV-VITEPLAGTRAfgRGAA 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 222 DvlDREAGNRLLASGKDRHEHELVTQAMKSVLgprsSQLSLPASPQLITTPTL------WHLATPIEGTALAEENAMSLA 295
Cdd:PRK07912 279 I--DRLARDDLESNSKEIVEHAISVRSSLAEI----TEIAEPGSAAVIDFMTVrergsvQHLGSTVRGRLDASSDRMDAL 352

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556278204 296 CLLHPTPALSGFPHQAAKRLIADLEPFDRQLFGGIVGWCDDEGNGEWVVTIRCARLQQRTLRLFAGAGIVPASSPLGEWR 375
Cdd:PRK07912 353 EALFPAVTASGIPKAAGVDAIFRLDEAPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFE 432


                 ....*....
gi 556278204 376 ETGVKLTTM 384
Cdd:PRK07912 433 ETCEKLSTL 441
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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