NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|556284588|ref|WP_023289927|]
View 

MULTISPECIES: dipeptide/tripeptide permease DtpA [Klebsiella]

Protein Classification

MFS transporter( domain architecture ID 10013279)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
tppB PRK09584
dipeptide/tripeptide permease DtpA;
1-501 0e+00

dipeptide/tripeptide permease DtpA;


:

Pssm-ID: 181969  Cd Length: 500  Bit Score: 951.12  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588   1 MSTANNKPAESVSLNAFKQPRAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL 80
Cdd:PRK09584   1 MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  81 GDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPRLDGAFTMYYMSIN 160
Cdd:PRK09584  81 GDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMATIAVGNGLFKANPSSLLSTCYEKDDPRLDGAFTMYYMSIN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 161 IGSFFSMLATPWLAARFGWSVAFALSVVGMVITIINFAFCQKWVKQYGSKPDFAPVHMGKLLATIAGVVVLVAIATWLLH 240
Cdd:PRK09584 161 IGSFFSMLATPWLAAKYGWSVAFALSVVGMLITVVNFAFCQRWVKQYGSKPDFEPINYRKLLLTIVGVVALIAIATWLLH 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 241 NQGIARMALGVIALGIVVIFAKEAMGLKGAARRKMIVAFLLMVEAIVFFVLYSQMPTSLNFFAIRNVEHSILGLAFEPEQ 320
Cdd:PRK09584 241 NQEIARMALGVVALGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGIAVEPEQ 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 321 YQALNPFWIMIGSPILAAIYNKMGDRLPMPHKFAIGMVLCSGAFLVLPLGAKFASDAGIVSVNWLILSYALQSIGELMIS 400
Cdd:PRK09584 321 YQALNPFWIMIGSPILAAIYNKMGDRLPMPHKFAIGMVLCSGAFLVLPLGAKFANDAGIVSVNWLIASYGLQSIGELMIS 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 401 GLGLAMVAQLVPQRLMGFIMGSWFLTTAGAAIIAGKIANLMAVPENVTDPLVSLEVYGHVFLQIGIVTAVIAALMLLTAP 480
Cdd:PRK09584 401 GLGLAMVAQLVPQRLMGFIMGSWFLTTAGAALIAGYVANLMAVPDNVTDPLMSLEVYGRVFLQIGIATAVIAVLMLLTAP 480
                        490       500
                 ....*....|....*....|.
gi 556284588 481 KLNRMTQDDSADvKARETAAA 501
Cdd:PRK09584 481 KLNRMTQDDSAD-KAAKAATA 500
 
Name Accession Description Interval E-value
tppB PRK09584
dipeptide/tripeptide permease DtpA;
1-501 0e+00

dipeptide/tripeptide permease DtpA;


Pssm-ID: 181969  Cd Length: 500  Bit Score: 951.12  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588   1 MSTANNKPAESVSLNAFKQPRAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL 80
Cdd:PRK09584   1 MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  81 GDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPRLDGAFTMYYMSIN 160
Cdd:PRK09584  81 GDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMATIAVGNGLFKANPSSLLSTCYEKDDPRLDGAFTMYYMSIN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 161 IGSFFSMLATPWLAARFGWSVAFALSVVGMVITIINFAFCQKWVKQYGSKPDFAPVHMGKLLATIAGVVVLVAIATWLLH 240
Cdd:PRK09584 161 IGSFFSMLATPWLAAKYGWSVAFALSVVGMLITVVNFAFCQRWVKQYGSKPDFEPINYRKLLLTIVGVVALIAIATWLLH 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 241 NQGIARMALGVIALGIVVIFAKEAMGLKGAARRKMIVAFLLMVEAIVFFVLYSQMPTSLNFFAIRNVEHSILGLAFEPEQ 320
Cdd:PRK09584 241 NQEIARMALGVVALGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGIAVEPEQ 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 321 YQALNPFWIMIGSPILAAIYNKMGDRLPMPHKFAIGMVLCSGAFLVLPLGAKFASDAGIVSVNWLILSYALQSIGELMIS 400
Cdd:PRK09584 321 YQALNPFWIMIGSPILAAIYNKMGDRLPMPHKFAIGMVLCSGAFLVLPLGAKFANDAGIVSVNWLIASYGLQSIGELMIS 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 401 GLGLAMVAQLVPQRLMGFIMGSWFLTTAGAAIIAGKIANLMAVPENVTDPLVSLEVYGHVFLQIGIVTAVIAALMLLTAP 480
Cdd:PRK09584 401 GLGLAMVAQLVPQRLMGFIMGSWFLTTAGAALIAGYVANLMAVPDNVTDPLMSLEVYGRVFLQIGIATAVIAVLMLLTAP 480
                        490       500
                 ....*....|....*....|.
gi 556284588 481 KLNRMTQDDSADvKARETAAA 501
Cdd:PRK09584 481 KLNRMTQDDSAD-KAAKAATA 500
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
17-490 6.76e-176

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 503.19  E-value: 6.76e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  17 FKQPRAFYLIFSIELWERFGYYGLQGIMAVYLVKQL-----GMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVI 91
Cdd:COG3104   10 FGHPKGLYTLFFTEMWERFSFYGMRAILVLYLTASLadgglGLSEADAAAIYGAYTALVYLTPLLGGWLADRLLGQRRAI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  92 MLGAIVLAIGYALVAWSGHDAAiVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPRLDGAFTMYYMSINIGSFFSMLATP 171
Cdd:COG3104   90 LLGGILMALGHFLLALPGGVTL-FYLGLALIAVGNGLFKPNISSLVGQLYDPGDPRRDAGFTIFYMGINIGAFLAPLLCG 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 172 WLAARFGWSVAFALSVVGMVITIINFAFCQKWVKQYGSKPDFAPVHMGKLLATIAGVVVLVAIATWLLHNQGIARMALGV 251
Cdd:COG3104  169 YLGEKYGWHYGFGAAAIGMLIGLIIFLLGRKYLGDIGLEPDNPLSKKERLIAVALGALLLVLVLAGLLSNANIANYLLYV 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 252 IALGIVVIFAKEAMGLKGAARRKMIVAFLLMVEAIVFFVLYSQMPTSLNFFAIRNVEHSILGLAFEPEQYQALNPFWIMI 331
Cdd:COG3104  249 IAIIAYFIFILRSKKLTKEERKRLLAILILFLFSIVFWALYEQAGTSLNLFADRNVDRSLFGFEIPPSWFQSLNPLFIII 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 332 GSPILAAIYNKMGDR---LPMPHKFAIGMVLCSGAFLVLPLGAKFASDAGIVSVNWLILSYALQSIGELMISGLGLAMVA 408
Cdd:COG3104  329 LAPVFAALWTKLGKRgkePSTPTKFALGLLLLGLGFLVMALAALLAGAGGKVSPLWLVLAYLLLTIGELCLSPVGLSMIT 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 409 QLVPQRLMGFIMGSWFLTTAGAAIIAGKIANLMAVPEnvtdplvslevYGHVFLQIGIVTAVIAALMLLTAPKLNRMTQD 488
Cdd:COG3104  409 KLAPARFAGQMMGLWFLATALGNLLAGLLAGLYAVPG-----------YTAYFLLLGGIALVAGVVLLLLSPKLRRLMHG 477

                 ..
gi 556284588 489 DS 490
Cdd:COG3104  478 VE 479
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
20-481 5.78e-141

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 411.20  E-value: 5.78e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  20 PRAFYLIFSIELWERFGYYGLQGIMAVYLVKQL--GMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIV 97
Cdd:cd17346    1 PKGLYTLFFTEMWERFSYYGMRAILILYLTAQLgdGFSEADAASIYGAYTALVYLTPIIGGWLADKVLGARRTVFIGGIL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  98 LAIGYALVAWSGHDAAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPRLDGAFTMYYMSINIGSFFSMLATPWLAARF 177
Cdd:cd17346   81 MALGYLLLALSPFSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDENDPRRDSGFSIFYMGINLGAFLAPLLCGTLGDNY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 178 GWSVAFALSVVGMVITIINFAFCQKWVKQygskpdfapvhmgkllatiagvvvlvaiatwllhnqgiarmalgvialgiv 257
Cdd:cd17346  161 GYHYGFGLAAVGMLLGLLIFLLGRKKLLE--------------------------------------------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 258 vifakeamglkgaaRRKMIVAFLLMVEAIVFFVLYSQMPTSLNFFAIRNVEHSILGLAFEPEQYQALNPFWIMIGSPILA 337
Cdd:cd17346  190 --------------RKKMLAIIILFLFAVVFWAIYEQAGTSLALFADENVDRLLGGFTIPPSWFQSLNPLFIILLAPILA 255
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 338 AIYNKMGDR---LPMPHKFAIGMVLCSGAFLVLPLGAKFASDAGIVSVNWLILSYALQSIGELMISGLGLAMVAQLVPQR 414
Cdd:cd17346  256 ALWTKLGKRgkdPSIPTKFALGLLLLGLSFLLMVLAASFAGGSGKVSALWLVLSYFLQTLGELCLSPVGLSMITKLAPAK 335
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556284588 415 LMGFIMGSWFLTTAGAAIIAGKIANLMAVPEnvtDPLVSLEVYGHVFLQIGIVTAVIAALMLLTAPK 481
Cdd:cd17346  336 FAGFMMGLWFLASALGNILAGYLAGFYAQPK---DPLASALVYTDYFGLIGVIALVAGIILLLLAKK 399
yjdL_sub1_fam TIGR00924
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ...
17-485 3.79e-121

amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273342 [Multi-domain]  Cd Length: 475  Bit Score: 363.39  E-value: 3.79e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588   17 FKQPRAFYLIFSIELWERFGYYGLQGIMAVYLVKQ--LGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLG 94
Cdd:TIGR00924   6 FGHPKPLFTLFFVELWERFSYYGMQGILAVYLVQQagLGFSQEQAFIIFGAYSALVYLLTSVGWWFGDRVWGTKKTMVLG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588   95 AIVLAIGYALVAWSGHDAAIvYMGMATIAVGNGLFKANPSSLLSTCYDKND-PRLDGAFTMYYMSINIGSFFSMLATPWL 173
Cdd:TIGR00924  86 GIVLMLGHFMLAMSIYPDLI-FYGLGTIAVGSGLFKANPSSMVGKLYERGDmPRRDGGFTLFYMSINIGSFISPLLAGVI 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  174 AARFGWSVAFALSVVGMVITIINFAFCQKWVKQYGSKPDFAPVHM---GKLLATIAGVVVLVAIATWLLHNQGIARMALG 250
Cdd:TIGR00924 165 AENYGYHVGFNLAAVGMVIGLLTFFAGRHMLRDIGSVPDPLSGQGktyGKLLLALLAALALVFFCAWLMHHVVIANILLM 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  251 VIALGIVVIFAKEAM--GLKGAARRKMIVAFLLMVEAIVFFVLYSQMPTSLNFFAIRNVEHSILGLAFEPEQYQALNPFW 328
Cdd:TIGR00924 245 TVTLAVIIFFFRLAFkpRLDAVARNKMYAYIVLFLEAVVFWVLYAQMPTSLNFFADNNMHHEMLGMSVPVIWFQSLNPFW 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  329 IMIGSPILAAIYNKMGDR---LPMPHKFAIGMVLCSGAFLVLPLGAKFASDAGIVSVNWLILSYALQSIGELMISGLGLA 405
Cdd:TIGR00924 325 VVVGSPVLAMIWTRLGRKgkdPTTPLKFTLGMLFCGASFLTFAASIWFADAGGLTSPWFMVLIYLFQTLGELMISPLGLS 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  406 MVAQLVPQRLMGFIMGSWFLTTAGAAIIAGKIANLMAVPENVTDplvslevyghVFLQIGIVTAVIAALMLLTAPKLNRM 485
Cdd:TIGR00924 405 WWTKIAPQRLMGQMLGMWFLAQAMGSLLGGYLATFGAVPQGVTG----------VFGKIGLVTLLVGVVMALMVPWLNRM 474
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
88-447 5.78e-95

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 293.07  E-value: 5.78e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588   88 KRVIMLGAIVLAIGYALVAWSGHD-------AAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPRLDGA-FTMYYMSI 159
Cdd:pfam00854   1 FRTIFLGSIIYAIGHILLALSAIPslrppvhVALFFIGLALIALGTGGIKPNVSSFGGDQFEETDPRRRSRfFSIFYFSI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  160 NIGSFFSMLATPWLAARFGWSVAFALSVVGMVITIINFAFCQKWVKQYGSKPDFAPVHMGKLLATI------AGVVVLVA 233
Cdd:pfam00854  81 NAGSLISTIITPYLQQNYGYPLGFGLPAVGMIIALLVFLLGSRMYKKKPPKGNVLTKVFKVLPVAAwnkvklNGSSAGIK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  234 IATWLLHNQGI-ARMALGVIALGIVVIFAKEAMglKGAARRKMIVAFLLMVEAIVFFVLYSQMPTSLNFFAiRNVEHSIL 312
Cdd:pfam00854 161 KLHWLDWARELdALIILGIVVPGIFFNIWCTKT--KVEEVKRLLRVLPLFLPLIMFWALYDQMGTSWVLQA-RTMNRKIG 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  313 GLAFEPEQYQALNPFWIMIGSPILAAIYNKMGDR----LPMPHKFAIGMVLCSGAFLVLPLGAKFASDAG---------I 379
Cdd:pfam00854 238 SFEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRKctggLTPLQKMAVGLFLASLAFAIAAIVQLKRNDTGpefpiaqevP 317
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556284588  380 VSVNWLILSYALQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGAAIIAGKIANLMAVPENV 447
Cdd:pfam00854 318 ISVLWLIPQYLLIGFGELFISIGGLEFFYKLAPKSMTSLITGLFLLTNALGNFLSGVIATLTAKPTNV 385
 
Name Accession Description Interval E-value
tppB PRK09584
dipeptide/tripeptide permease DtpA;
1-501 0e+00

dipeptide/tripeptide permease DtpA;


Pssm-ID: 181969  Cd Length: 500  Bit Score: 951.12  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588   1 MSTANNKPAESVSLNAFKQPRAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL 80
Cdd:PRK09584   1 MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  81 GDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPRLDGAFTMYYMSIN 160
Cdd:PRK09584  81 GDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMATIAVGNGLFKANPSSLLSTCYEKDDPRLDGAFTMYYMSIN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 161 IGSFFSMLATPWLAARFGWSVAFALSVVGMVITIINFAFCQKWVKQYGSKPDFAPVHMGKLLATIAGVVVLVAIATWLLH 240
Cdd:PRK09584 161 IGSFFSMLATPWLAAKYGWSVAFALSVVGMLITVVNFAFCQRWVKQYGSKPDFEPINYRKLLLTIVGVVALIAIATWLLH 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 241 NQGIARMALGVIALGIVVIFAKEAMGLKGAARRKMIVAFLLMVEAIVFFVLYSQMPTSLNFFAIRNVEHSILGLAFEPEQ 320
Cdd:PRK09584 241 NQEIARMALGVVALGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGIAVEPEQ 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 321 YQALNPFWIMIGSPILAAIYNKMGDRLPMPHKFAIGMVLCSGAFLVLPLGAKFASDAGIVSVNWLILSYALQSIGELMIS 400
Cdd:PRK09584 321 YQALNPFWIMIGSPILAAIYNKMGDRLPMPHKFAIGMVLCSGAFLVLPLGAKFANDAGIVSVNWLIASYGLQSIGELMIS 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 401 GLGLAMVAQLVPQRLMGFIMGSWFLTTAGAAIIAGKIANLMAVPENVTDPLVSLEVYGHVFLQIGIVTAVIAALMLLTAP 480
Cdd:PRK09584 401 GLGLAMVAQLVPQRLMGFIMGSWFLTTAGAALIAGYVANLMAVPDNVTDPLMSLEVYGRVFLQIGIATAVIAVLMLLTAP 480
                        490       500
                 ....*....|....*....|.
gi 556284588 481 KLNRMTQDDSADvKARETAAA 501
Cdd:PRK09584 481 KLNRMTQDDSAD-KAAKAATA 500
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
17-490 6.76e-176

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 503.19  E-value: 6.76e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  17 FKQPRAFYLIFSIELWERFGYYGLQGIMAVYLVKQL-----GMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVI 91
Cdd:COG3104   10 FGHPKGLYTLFFTEMWERFSFYGMRAILVLYLTASLadgglGLSEADAAAIYGAYTALVYLTPLLGGWLADRLLGQRRAI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  92 MLGAIVLAIGYALVAWSGHDAAiVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPRLDGAFTMYYMSINIGSFFSMLATP 171
Cdd:COG3104   90 LLGGILMALGHFLLALPGGVTL-FYLGLALIAVGNGLFKPNISSLVGQLYDPGDPRRDAGFTIFYMGINIGAFLAPLLCG 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 172 WLAARFGWSVAFALSVVGMVITIINFAFCQKWVKQYGSKPDFAPVHMGKLLATIAGVVVLVAIATWLLHNQGIARMALGV 251
Cdd:COG3104  169 YLGEKYGWHYGFGAAAIGMLIGLIIFLLGRKYLGDIGLEPDNPLSKKERLIAVALGALLLVLVLAGLLSNANIANYLLYV 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 252 IALGIVVIFAKEAMGLKGAARRKMIVAFLLMVEAIVFFVLYSQMPTSLNFFAIRNVEHSILGLAFEPEQYQALNPFWIMI 331
Cdd:COG3104  249 IAIIAYFIFILRSKKLTKEERKRLLAILILFLFSIVFWALYEQAGTSLNLFADRNVDRSLFGFEIPPSWFQSLNPLFIII 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 332 GSPILAAIYNKMGDR---LPMPHKFAIGMVLCSGAFLVLPLGAKFASDAGIVSVNWLILSYALQSIGELMISGLGLAMVA 408
Cdd:COG3104  329 LAPVFAALWTKLGKRgkePSTPTKFALGLLLLGLGFLVMALAALLAGAGGKVSPLWLVLAYLLLTIGELCLSPVGLSMIT 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 409 QLVPQRLMGFIMGSWFLTTAGAAIIAGKIANLMAVPEnvtdplvslevYGHVFLQIGIVTAVIAALMLLTAPKLNRMTQD 488
Cdd:COG3104  409 KLAPARFAGQMMGLWFLATALGNLLAGLLAGLYAVPG-----------YTAYFLLLGGIALVAGVVLLLLSPKLRRLMHG 477

                 ..
gi 556284588 489 DS 490
Cdd:COG3104  478 VE 479
PRK10207 PRK10207
dipeptide/tripeptide permease DtpB;
11-485 6.94e-175

dipeptide/tripeptide permease DtpB;


Pssm-ID: 182306  Cd Length: 489  Bit Score: 500.89  E-value: 6.94e-175
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  11 SVSLNAFKQPRAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRV 90
Cdd:PRK10207   4 TAPMGLLQQPRPFFMIFFVELWERFGYYGVQGILAVFFVKQLGFSQEQAFITFGAFAALVYGLISIGGYVGDHLLGTKRT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  91 IMLGAIVLAIGYALVAWSGHDAAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPRLDGAFTMYYMSINIGSFFSMLAT 170
Cdd:PRK10207  84 IVLGAIVLAIGYFMTGMSLLKPDLIFIALGTIAVGNGLFKANPASLLSKCYPPKDPRLDGAFTLFYMSINIGSLISLSLA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 171 PWLAARFGWSVAFALSVVGMVITIINFAFCQKWVKQYGSKPDFAPVHMGKLLATIAGVVVLVAIATWLLHNQGIARMALG 250
Cdd:PRK10207 164 PVIADKFGYSVTYNLCGAGLIIALLVYFACRGMVKDIGSEPDHKPMSFSKLLLVLLGSVVMIFVCAWLMHNVEVANLVLI 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 251 VIALGIVVIFAKEAMGLKGAARRKMIVAFLLMVEAIVFFVLYSQMPTSLNFFAIRNVEHSILGLAFEPEQYQALNPFWIM 330
Cdd:PRK10207 244 VLSIVVTIIFFREAFKLDKTGRNKMFVAFVLMLEAVVFYILYAQMPTSLNFFAINNVHHEILGFSINPVSFQALNPFWVV 323
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 331 IGSPILAAIYNKMGDR---LPMPHKFAIGMVLCSGAFLVLPL-GAKFASDAGIVSVNWLILSYALQSIGELMISGLGLAM 406
Cdd:PRK10207 324 VASPILAGIYTHLGSKgkdLSMPMKFTLGMFLCSLGFLTAAAaGMWFADAQGLTSPWFIVLVYLFQSLGELFISALGLAM 403
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556284588 407 VAQLVPQRLMGFIMGSWFLTTAGAAIIAGKIANLMAVPENVTDPLVSLEVYGHVFLQIGIVTAVIAALMLLTAPKLNRM 485
Cdd:PRK10207 404 IAALVPQHLMGFILGMWFLTQAAAFLLGGYVATFTAVPDNITDPLETLPVYTNVFGKIGLVTLGVAVVMALMVPWLNRM 482
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
20-481 5.78e-141

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 411.20  E-value: 5.78e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  20 PRAFYLIFSIELWERFGYYGLQGIMAVYLVKQL--GMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIV 97
Cdd:cd17346    1 PKGLYTLFFTEMWERFSYYGMRAILILYLTAQLgdGFSEADAASIYGAYTALVYLTPIIGGWLADKVLGARRTVFIGGIL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  98 LAIGYALVAWSGHDAAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPRLDGAFTMYYMSINIGSFFSMLATPWLAARF 177
Cdd:cd17346   81 MALGYLLLALSPFSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDENDPRRDSGFSIFYMGINLGAFLAPLLCGTLGDNY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 178 GWSVAFALSVVGMVITIINFAFCQKWVKQygskpdfapvhmgkllatiagvvvlvaiatwllhnqgiarmalgvialgiv 257
Cdd:cd17346  161 GYHYGFGLAAVGMLLGLLIFLLGRKKLLE--------------------------------------------------- 189
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 258 vifakeamglkgaaRRKMIVAFLLMVEAIVFFVLYSQMPTSLNFFAIRNVEHSILGLAFEPEQYQALNPFWIMIGSPILA 337
Cdd:cd17346  190 --------------RKKMLAIIILFLFAVVFWAIYEQAGTSLALFADENVDRLLGGFTIPPSWFQSLNPLFIILLAPILA 255
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 338 AIYNKMGDR---LPMPHKFAIGMVLCSGAFLVLPLGAKFASDAGIVSVNWLILSYALQSIGELMISGLGLAMVAQLVPQR 414
Cdd:cd17346  256 ALWTKLGKRgkdPSIPTKFALGLLLLGLSFLLMVLAASFAGGSGKVSALWLVLSYFLQTLGELCLSPVGLSMITKLAPAK 335
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556284588 415 LMGFIMGSWFLTTAGAAIIAGKIANLMAVPEnvtDPLVSLEVYGHVFLQIGIVTAVIAALMLLTAPK 481
Cdd:cd17346  336 FAGFMMGLWFLASALGNILAGYLAGFYAQPK---DPLASALVYTDYFGLIGVIALVAGIILLLLAKK 399
yjdL_sub1_fam TIGR00924
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ...
17-485 3.79e-121

amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273342 [Multi-domain]  Cd Length: 475  Bit Score: 363.39  E-value: 3.79e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588   17 FKQPRAFYLIFSIELWERFGYYGLQGIMAVYLVKQ--LGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLG 94
Cdd:TIGR00924   6 FGHPKPLFTLFFVELWERFSYYGMQGILAVYLVQQagLGFSQEQAFIIFGAYSALVYLLTSVGWWFGDRVWGTKKTMVLG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588   95 AIVLAIGYALVAWSGHDAAIvYMGMATIAVGNGLFKANPSSLLSTCYDKND-PRLDGAFTMYYMSINIGSFFSMLATPWL 173
Cdd:TIGR00924  86 GIVLMLGHFMLAMSIYPDLI-FYGLGTIAVGSGLFKANPSSMVGKLYERGDmPRRDGGFTLFYMSINIGSFISPLLAGVI 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  174 AARFGWSVAFALSVVGMVITIINFAFCQKWVKQYGSKPDFAPVHM---GKLLATIAGVVVLVAIATWLLHNQGIARMALG 250
Cdd:TIGR00924 165 AENYGYHVGFNLAAVGMVIGLLTFFAGRHMLRDIGSVPDPLSGQGktyGKLLLALLAALALVFFCAWLMHHVVIANILLM 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  251 VIALGIVVIFAKEAM--GLKGAARRKMIVAFLLMVEAIVFFVLYSQMPTSLNFFAIRNVEHSILGLAFEPEQYQALNPFW 328
Cdd:TIGR00924 245 TVTLAVIIFFFRLAFkpRLDAVARNKMYAYIVLFLEAVVFWVLYAQMPTSLNFFADNNMHHEMLGMSVPVIWFQSLNPFW 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  329 IMIGSPILAAIYNKMGDR---LPMPHKFAIGMVLCSGAFLVLPLGAKFASDAGIVSVNWLILSYALQSIGELMISGLGLA 405
Cdd:TIGR00924 325 VVVGSPVLAMIWTRLGRKgkdPTTPLKFTLGMLFCGASFLTFAASIWFADAGGLTSPWFMVLIYLFQTLGELMISPLGLS 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  406 MVAQLVPQRLMGFIMGSWFLTTAGAAIIAGKIANLMAVPENVTDplvslevyghVFLQIGIVTAVIAALMLLTAPKLNRM 485
Cdd:TIGR00924 405 WWTKIAPQRLMGQMLGMWFLAQAMGSLLGGYLATFGAVPQGVTG----------VFGKIGLVTLLVGVVMALMVPWLNRM 474
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
88-447 5.78e-95

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 293.07  E-value: 5.78e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588   88 KRVIMLGAIVLAIGYALVAWSGHD-------AAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPRLDGA-FTMYYMSI 159
Cdd:pfam00854   1 FRTIFLGSIIYAIGHILLALSAIPslrppvhVALFFIGLALIALGTGGIKPNVSSFGGDQFEETDPRRRSRfFSIFYFSI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  160 NIGSFFSMLATPWLAARFGWSVAFALSVVGMVITIINFAFCQKWVKQYGSKPDFAPVHMGKLLATI------AGVVVLVA 233
Cdd:pfam00854  81 NAGSLISTIITPYLQQNYGYPLGFGLPAVGMIIALLVFLLGSRMYKKKPPKGNVLTKVFKVLPVAAwnkvklNGSSAGIK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  234 IATWLLHNQGI-ARMALGVIALGIVVIFAKEAMglKGAARRKMIVAFLLMVEAIVFFVLYSQMPTSLNFFAiRNVEHSIL 312
Cdd:pfam00854 161 KLHWLDWARELdALIILGIVVPGIFFNIWCTKT--KVEEVKRLLRVLPLFLPLIMFWALYDQMGTSWVLQA-RTMNRKIG 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  313 GLAFEPEQYQALNPFWIMIGSPILAAIYNKMGDR----LPMPHKFAIGMVLCSGAFLVLPLGAKFASDAG---------I 379
Cdd:pfam00854 238 SFEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRKctggLTPLQKMAVGLFLASLAFAIAAIVQLKRNDTGpefpiaqevP 317
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556284588  380 VSVNWLILSYALQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGAAIIAGKIANLMAVPENV 447
Cdd:pfam00854 318 ISVLWLIPQYLLIGFGELFISIGGLEFFYKLAPKSMTSLITGLFLLTNALGNFLSGVIATLTAKPTNV 385
PRK15462 PRK15462
dipeptide permease;
19-442 8.47e-52

dipeptide permease;


Pssm-ID: 237971 [Multi-domain]  Cd Length: 493  Bit Score: 183.23  E-value: 8.47e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  19 QPRAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVL 98
Cdd:PRK15462   7 QPRAIYYVVALQIWEYFSFYGMRALLILYLTNQLKYDDNHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVMLGALLM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  99 AIGYALVAWSGHDAAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPRLDGAFTMYYMSINIGSFFSMLATPWLAARFG 178
Cdd:PRK15462  87 AIGHVVLGASEIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYEPTDPRRDGGFSLMYAAGNVGSIIAPIACGYAQEEYS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 179 WSVAFALSVVGMVITII-------NFAFCQKWVKQYGSKPDFAPVHMGKLLATIAGVVVLVAIATWLLHNQgIARMALGV 251
Cdd:PRK15462 167 WAMGFGLAAVGMIAGLViflcgnrHFTHTRGVNKKVLRATNFLLPNWGWLLVLLVATPALITVLFWKEWSV-YALIVATI 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 252 IALGIVVIFAKEAMGLKGAARRKMIVAFLLMveAIVFFVLYSQMPTSLNFFAIRNVEHSILGLAFEPEQYQALNPFWIMI 331
Cdd:PRK15462 246 IGLGVLAKIYRKAENQKQRKELGLIVTLTFF--SMLFWAFAQQGGSSISLYIDRFVNRDMFGYTVPTAMFQSINAFAVML 323
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 332 GSPILAAIYNKM--GDR-LPMPHKFAIGMVLCSGAFLVLPLGAKFASDAGIVSVNWLILSYALQSIGELMISGLGLAMVA 408
Cdd:PRK15462 324 CGVFLAWVVKESvaGNRtVRIWGKFALGLGLMSAGFCILTLSARWSAMYGHSSLPLMVLGLAVMGFAELFIDPVAMSQIT 403
                        410       420       430
                 ....*....|....*....|....*....|....
gi 556284588 409 QLVPQRLMGFIMGSWFLttagaaiIAGKIANLMA 442
Cdd:PRK15462 404 RIEIPGVTGVLTGIYML-------LSGAIANYLA 430
MFS_POT cd06175
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ...
23-481 1.61e-48

Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340865 [Multi-domain]  Cd Length: 422  Bit Score: 172.62  E-value: 1.61e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  23 FYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGY 102
Cdd:cd06175    1 CAMILLIELCERFTFYGIGANLVPFLTGALGLGNAQAANVVLNFLGTSYVTPLFGGWIADTFLGRYRTILIGAAIYAVGV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 103 ALVAWSGHDAA--------------------IVYMGMATIAVGNGLFKANPSSLLSTCYDKNDP-RLDGAFTMYYMSINI 161
Cdd:cd06175   81 AILTVSTIPPGlrplrcnpshceqasgiqltGFYAALYLIALGTGGVKANVSPLGADQFDERGPsKTQSFFNWFYFCINV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 162 GSFFSMLATPWLAARFGWSVAFALSVVGMVITIINFafcqkwvkqygskpdfapvhmgkllatiagvvvlvaiatwllhn 241
Cdd:cd06175  161 GSLLAMLGTPYIQDNVGWAAAYGIPFVAILLALVVF-------------------------------------------- 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 242 qgiarmalgvialgivvifakeamglkgaARRKMIVAFLLMVEAIVFFVLYSQMPTSLNFFAIRNVEhSILGLAFEPEQY 321
Cdd:cd06175  197 -----------------------------EVKQLLRALPLFAFCILFWTVYAQMTTSYVLQALTLVR-STGLFTIPPASM 246
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 322 QALNPFWIMIGSPILAAIYNKMGDRLPMP----HKFAIGMVLCSGAFLVLPLGAKFASDAGI----------VSVNWLIL 387
Cdd:cd06175  247 QAFNPILLLLLIPVLDKVVYPLIRRYGVGlsplTKIGLGFFFGSLSMFVAGFLELKRLNTAHahgpvvttspLSFWWQIP 326
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 388 SYALQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGAAIIAGKIANLMAVPE--NVTDPLVSLEVYGHVFLQIG 465
Cdd:cd06175  327 QYLLLGIGEILVSITGLEFAYREAPKSMKGFIMGLLLLTSGFGSFFGSVLVTLVSKPTdgAHIADDLNKGVLTNFFFLLA 406
                        490
                 ....*....|....*.
gi 556284588 466 IVTAVIAALMLLTAPK 481
Cdd:cd06175  407 VLAALNFLIFLLVSRK 422
MFS_SLC15A1_2_like cd17347
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ...
20-475 1.04e-41

Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340905 [Multi-domain]  Cd Length: 427  Bit Score: 154.31  E-value: 1.04e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  20 PRAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLA 99
Cdd:cd17347    1 PRAVPFIVGNEFCERFSYYGMRAILVLYLTDFLGFSEAEATAIYHSFVMLCYFFPLLGAIIADSYLGKYRTILYLSLVYC 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 100 IGYALVAWSGHDA------AIVYMGMATIAVGNGLFKANPSSLLSTCYD-KNDPRLDGAFTMYYMSINIGSFFSMLATPW 172
Cdd:cd17347   81 LGHIVLAVTAIPPlgpphvWGLLIGLLLIAIGTGGIKPCVSAFGGDQFGaDQQHLLARFFSWFYFAINAGSLLSTFLTPI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 173 LAA------RFGWSVAFALSVVGMVITIINFAFCQKWVKQYGSkpdfapvhmgkllatiagvvvlvaiatwLLHnqgiar 246
Cdd:cd17347  161 LRAdvqfggHDCYPLAFGVPGVLMAVATLVFWLGRKHYKDVKA----------------------------LLR------ 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 247 malgvialgIVVIFakeamglkgaarrkmivAFLlmveaIVFFVLYSQMPTSLNFFAIRnVEHSILGLAFEPEQYQALNP 326
Cdd:cd17347  207 ---------VLVLF-----------------IPL-----PVFWALFDQQGSRWTLQAEQ-MDGLVGGFTILPDQMQALNP 254
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 327 FWIMIGSPILAA-IY---NKMGDRLPMPHKFAIGMVLCSGAFLV-------LPLGAKFASDAGI-----------VSVNW 384
Cdd:cd17347  255 ILILILIPLFDYvIYpllERCGIPLTPLRKMGVGMILAALAFVIagflqlrIDGGLPGQPDPGEvttfediepnsVSILW 334
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 385 LILSYALQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGAAIIAGKIANLMAVPENVTdplvslevYGHVFLQI 464
Cdd:cd17347  335 QLPQYVVLTAGEVLFSITGLEFAYTQAPKSMKSVVQAAWLLTVALGNLIVVIVAELIQFSSQAA--------EYFFFAGL 406
                        490
                 ....*....|.
gi 556284588 465 GIVTAVIAALM 475
Cdd:cd17347  407 MLVVAVVFALL 417
2A1704 TIGR00926
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ...
35-366 3.38e-18

Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273343 [Multi-domain]  Cd Length: 654  Bit Score: 87.89  E-value: 3.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588   35 FGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALVAWSG----- 109
Cdd:TIGR00926   1 FSYYGMRTILVLYFLNFLGFSESTSTVLFHTFTYLCYLTPLIGAIIADGWLGKFKTILYLSIVYVVGHALLSFGAipssg 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  110 --HDAAIVYMGMATIAVGNG------------LFKANPSSLLSTcydkndprldgAFTMYYMSINIGSFFSMLATPWLAA 175
Cdd:TIGR00926  81 hpLHDLLDLLGLALIALGTGgikpcvsafggdQFEERQLSLRSR-----------FFSFFYFAINAGSLISTIITPILRG 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  176 RFG-------WSVAFALSVVGMVITIINFAFCQKWVKqygsKPDFAPVHMGKLLATIAGvvvlvAIATWLLHNQGIARMA 248
Cdd:TIGR00926 150 DVGcfgcqdcYPLAFGVPAILMILALIVFMAGSKMYK----KKPPKGNIVSKVIKCIVT-----ALRKRFSTRSEHWPLH 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  249 LgvialgivVIFAKEAMGLKGAAR-RKMIVAFLLMVEAIVFFVLYSQMPTSLNFFAIRnVEHSILGLAFEPEQYQALNPF 327
Cdd:TIGR00926 221 W--------LDYAKDKHDIRMIRStKRLLRVLVLFIPLPMFWALFDQQGSRWTLQATR-MDGDVGGFEIQPDQMQVVNPL 291
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 556284588  328 WIMIGSPI----LAAIYNKMGDRLPMPHKFAIGMVLCSGAFLV 366
Cdd:TIGR00926 292 LILIFVPIfdyiVYPAIAKCGTRFTSLRKMAVGGLLAALSFFV 334
MFS_SLC15A1 cd17412
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute ...
20-480 1.20e-16

Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 1 (SLC15A1), also called peptide transporter 1 (PepT1), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A1, as well as SLC15A2, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1 is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. It is a high-capacity/low-affinity transporter that drives the transport of di-and tripeptides for metabolic purposes. It's expression is upregulated in the colon during chronic inflammation associated with inflammatory bowel disease. SLC15A1/PepT1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340970 [Multi-domain]  Cd Length: 415  Bit Score: 81.81  E-value: 1.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  20 PRAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLA 99
Cdd:cd17412    1 PLSIFFIVVNEFCERFSYYGMRAVLVLYFKYFLRWDDDLSTAIYHTFVALCYLTPILGAIIADSWLGKFKTIVYLSIVYT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 100 IGYALVAWSG-HD----------------AAIVYMGMATIAVGNGLFKANPSSLLSTCYDKN-DPRLDGAFTMYYMSINI 161
Cdd:cd17412   81 IGQAVMAVSAiHDltdanrdgtpdnltlhVALSMIGLLLIALGTGGIKPCVAAFGGDQFEEHqEKQRSRFFSIFYLSINA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 162 GSFFSMLATPWLAArfgwsvafalsvvgmvitiinfafcqkwvKQYGSKPdfapvhmgkllatiagvvvlvaiatwllhN 241
Cdd:cd17412  161 GSLLSTIITPILRS-----------------------------QECGIHS-----------------------------K 182
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 242 QGIARMALGVIALGIVVIFAKEAMGLKGAARRKMIVAFL-LMVEAIVFFVLYSQMPTSLNFFAIrNVEHSILGLAFEPEQ 320
Cdd:cd17412  183 QKCYPLAFGVPAALMVVALIVFILGSKMYKQIKMVLKVLfLYIPLPMFWALFDQQGSRWTLQAT-TMDGNFGAIQIQPDQ 261
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 321 YQALNPFWIMIGSPIL-AAIY---NKMGDRLPMPHKFAIGMVLCSGAFLVLPLGAkfasdagiVSVNWLILSYALQSIGE 396
Cdd:cd17412  262 MQTVNPILIIIMVPIFdAVIYpliKKCKINFTPLRKMTVGMFLAALAFVAAALLQ--------IQMAWQIPQYFLLTCGE 333
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 397 LMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGAAIIAGKIANLMAVPENVTDPLvsleVYGHVFLQIGIVTAVIAALML 476
Cdd:cd17412  334 VVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAEAGSISEQWAEYV----LFAALLVAVCIIFAIMAYFYT 409

                 ....
gi 556284588 477 LTAP 480
Cdd:cd17412  410 YVDP 413
MFS_NPF cd17351
Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant ...
25-198 8.07e-16

Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340909 [Multi-domain]  Cd Length: 445  Bit Score: 79.59  E-value: 8.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  25 LIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYAL 104
Cdd:cd17351    3 FILGNEFAERLAFYGIAVNLVTYLTKVMHLSNAKAANTVTNFSGTSYLTPLLGAFLADAYLGRYWTIAIFSVIYLVGLIL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 105 VAWS---------------------GHDAAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPR----LDGAFTMYYMSI 159
Cdd:cd17351   83 LTLSasvpslrpppcnpdspcepasSTQLTVLYVGLYLIALGTGGIKPCVSAFGADQFDETDPKekkqKPSFFNWFYFSI 162
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 556284588 160 NIGSFFSMLATPWLAARFGWSVAFALSVVGMVITIINFA 198
Cdd:cd17351  163 NLGSLLAVTLVVYIQDNVSWGWGFGIPAAAMALAVIVFV 201
MFS_NPF6 cd17413
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The ...
25-197 1.13e-14

NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter 1/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF6 includes the first identified member of the NRT1/PTR family: Arabidopsis thaliana NRT1.1, now called AtNPF6.3. It is a dual affinity nitrate influx transporter and a nitrate sensor. It also transports auxin and has nitrate efflux activity. NPF6 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340971 [Multi-domain]  Cd Length: 457  Bit Score: 75.95  E-value: 1.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  25 LIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYAL 104
Cdd:cd17413    6 LILGIEMCERLTTLGIGVNLVTYLTGTMHLPSATSANIVTNFLGTSFLLCLLGGFIADTFLGRYLTIAIFASIQALGVLV 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 105 VAWS-----------------------GHDAAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPR----LDGAFTMYYM 157
Cdd:cd17413   86 LTLSttlpslrpppcnhttshhcepasGIQLTVLYLALYLIALGTGGIKSSVSGFGSDQFDENDPKerklMSYFFNRFFF 165
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 556284588 158 SINIGSFFSMLATPWLAARFGWSVAFALSVVGMVITIINF 197
Cdd:cd17413  166 CISVGSLLAVTVLVYIQDNVGRGWGYGICAAAMVLAIVVF 205
MFS_NPF5 cd17417
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ...
21-197 3.48e-14

NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340975 [Multi-domain]  Cd Length: 452  Bit Score: 74.61  E-value: 3.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  21 RAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAI 100
Cdd:cd17417    2 KACSFIIGIEVAERFAYYGIASNLVTYLTTPLHQSTARAAKNVNNWSGTATLLPLLGAFVADAYLGRYRTILISSLIYLL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 101 GYALVAWS----GHDA---------------AIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPRLDGA----FTMYYM 157
Cdd:cd17417   82 GLVLLTLSaslpSLKPpecngtcskastlqvAFFFFSLYLVAIGQGGHKPCVQAFGADQFDEDDPKEKKQkssfFNWWYF 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 556284588 158 SINIGSFFSMLATPWLAARFGWSVAFALSVVGMVITIINF 197
Cdd:cd17417  162 SICAGSLTAVTVLVYIQDNVGWALGFGIPTIVMALALFVF 201
MFS_NPF4 cd17414
NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The ...
21-198 5.37e-14

NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. Members of the NPF4 subfamily have been shown to transport ABA. NPF4 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340972 [Multi-domain]  Cd Length: 456  Bit Score: 73.98  E-value: 5.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  21 RAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAI 100
Cdd:cd17414    2 RAAFFVLVVEALENMAYLANANNLVTYLINNMHYSLAKSANIVTNFVGTAFLLALLGGFLSDSFLSSFKTIIIFGSIELL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 101 GYALVAWSGH-----------------------DAAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDP----RLDGAFT 153
Cdd:cd17414   82 GLILLTVQAHipslqppscnslgdltckepsgsQAAILFVGLYLVALGVGCIKPNLPSHGADQFDENDPkgrrQLSSFFN 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 556284588 154 MYYMSINIGSFFSMLATPWLAARFGWSVAFALSVVGMVITIINFA 198
Cdd:cd17414  162 WYYFSFSLGALIAVTLVVWVEENKGWDWGFGVSAAVIAVGILVFV 206
MFS_PTR2 cd17350
Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide ...
20-212 2.76e-13

Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide transporter or permease PTR2 is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. It is a 12-transmembrane domain (TMD) integral membrane protein that translocates di-/tripeptides. As with other POT family proteins, it displays characteristic substrate multispecificity. PTR2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340908 [Multi-domain]  Cd Length: 438  Bit Score: 71.73  E-value: 2.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  20 PRAFYLIFSIELWERFGYYGLQGIMAVYL----------VKQLGMSEADSITLFSSFSALVYGLvaIGGWLGDKVLGTKR 89
Cdd:cd17350    1 PWSAFLIAIVELCERFSYYGLTGPFQNYMqfgpddstpgALGLGEQGATGLSNFFTFWCYVTPV--IGAYVADQFLGRYN 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  90 VIMLGAIVLAIGYALVAWSG------HDAAI--VYMGMATIAVGNGLFKANPSSLLSTCYDKNDP--------------- 146
Cdd:cd17350   79 TIVCGAVIYFVGILILTCTSipsvidAGAGLggFVVAIIIIGLGTGGIKSNVSPLIADQLPKIKPyvktlkngervivdp 158
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556284588 147 --RLDGAFTMYYMSINIGSfFSMLATPWLAARFGWSVAFALSVVGMVITIINFAFCQkwvKQYGSKPD 212
Cdd:cd17350  159 vvTLSRIYMIFYWAINVGS-LSLLATTYLERTKGFWYAYLLPLCVFVIPLIILAFGK---KFYKIRPD 222
MFS_NPF8 cd17418
NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The ...
21-199 4.90e-13

NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF8 contains the Arabidopsis dipeptide transporters AtNPF8.1 (PTR1), AtNPF8.2 (PTR5), and AtNPF8.3 (PTR2), as well as tonoplast-localized transporters AtNPF8.4 (PTR4) and AtNPF8.5 (PTR6). Oryza sativa NRT1 (now called OsNPF8.9) is a low-affinity nitrate transporter. NPF8 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340976 [Multi-domain]  Cd Length: 447  Bit Score: 70.96  E-value: 4.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  21 RAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAI 100
Cdd:cd17418    2 KACPFILGNECCERLAYYGIATNLITYLTKELHQGNVSAANNVTNWSGTCYITPLIGAFIADAYWGRYWTIASFSAIYFI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 101 GYALVAWSGH--------------------DAAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDP----RLDGAFTMYY 156
Cdd:cd17418   82 GMVLLTLSASvpglkpascigslcppatsvQYAVFFLGLYLIALGTGGIKPCVSSFGADQFDDTDPkekvRKSSFFNWFY 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 556284588 157 MSINIGSFFSMLATPWLAARFGWSVAFALSVVGMVITIINFAF 199
Cdd:cd17418  162 FSINIGALISSSVLVWIQENVGWGWGFGIPTVFMGIAIVSFFF 204
MFS_SLC15A2 cd17411
Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute ...
20-433 2.58e-12

Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 2 (SLC15A2), also called peptide transporter 2 (PepT2), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A2, as well as SLC15A1, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A2 is a high-affinity transporter and is abundantly expressed in the apical membrane of kidney proximal tubules and choroid plexus epithelial cells. It is the major transporter involved in the reclamation of peptide-bound amino acids and peptide-like drugs in the kidney, and is also called the renal isoform. In choroid plexus and the brain, it acts as an efflux transporter and plays a role in regulating peptide/neuropeptide homeostasis. SLC15A2/PepT2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340969 [Multi-domain]  Cd Length: 403  Bit Score: 68.31  E-value: 2.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  20 PRAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLA 99
Cdd:cd17411    1 PLSIAFIVVNEFCERFSYYGMKAVLTLYFLSFLHWDENLSTAIYHAFSGLCYFTPVLGALIADSWLGKFKTIIYLSIVYV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 100 IGYAL--------VAWSGHDAAIVYMGMATIAVGNGLFKANPSSLLSTCYD-KNDPRLDGAFTMYYMSINIGSFFSMLAT 170
Cdd:cd17411   81 VGHVIksvgaiptVGDQQVHVVLSMIGLFLIALGTGGIKPCVAAFGGDQFEeEHARERSKFFSIFYLSINAGSLISTFVT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 171 PWLAARfgwsvafalsvvgmvitiinfafcqkwVKQYGskpdfapvhmGKLLAtiagvvvlvaiatwllhnqgiarMALG 250
Cdd:cd17411  161 PILRGD---------------------------VQCFG----------GDCYA-----------------------LAFG 180
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 251 VIALGIVVIFAKEAMGLKGAARRKMIVAFL-LMVEAIVFFVLYSQMPTSLNFFAIRnVEHSILGLAFEPEQYQALNPFWI 329
Cdd:cd17411  181 VPAALMVVALVVFIAGSGMYKEVKMVTRVLfLYIPLPMFWALFDQQGSRWTLQATR-MNDFGGGFVLQPDQMQTLNPLLI 259
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 330 MIGSPI----LAAIYNKMGDRLPMPHKFAIGMVLCSGAFLVlplgakfaSDAGIVSVNWLILSYALQSIGELMISGLGLA 405
Cdd:cd17411  260 LVFIPIfdlgIYPLVSKCKINFTSLRKMATGMILAALAFAV--------AAAVEIKIAWQLPQYVLLSAGEVMFSITGLE 331
                        410       420
                 ....*....|....*....|....*...
gi 556284588 406 MVAQLVPQRLMGFIMGSWFLTTAGAAII 433
Cdd:cd17411  332 FSYSQAPASMKSVLQAGWLLTVAFGNVI 359
MFS_NPF1_2 cd17416
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ...
30-197 2.17e-08

NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340974 [Multi-domain]  Cd Length: 444  Bit Score: 56.51  E-value: 2.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  30 ELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALVAW-- 107
Cdd:cd17416    8 ETGEKLASYGLLANLIVYLIEEYNMKSIAAANIINIWSGTTNFLPVVGAFLSDSYFGRFPTISVGSFASLLGMVLLTLta 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 108 --------------------SGHDAAIVYMGMATIAVGNGlfKANPSSL------LSTCYDKNDPRLDGAFTMYYMSINI 161
Cdd:cd17416   88 aipslrpppcetasslcqspSKLQLAVLYSALALLSIGAG--GIRPCSLafgadqFDKKTESGKRGLESFFNWYYFTFTV 165
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 556284588 162 GSFFSMLATPWLAARFGWSVAFALSVVGMVITIINF 197
Cdd:cd17416  166 AQIISLTAIVYIQDNVSWKIGFGIPAALMLLSFILF 201
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
35-195 3.93e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 55.26  E-value: 3.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  35 FGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAAI 114
Cdd:COG2271  194 FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPAL 273
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 115 VYMGMATIAVGNGLFKANPSSLLSTCYDKNdpRLDGAFTMYYMSINIGSFFSMLATPWLAARFGWSVAFALSVVGMVITI 194
Cdd:COG2271  274 AIALLFLAGFGLGGAFGLLWALAAELFPKK--ARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAA 351

                 .
gi 556284588 195 I 195
Cdd:COG2271  352 L 352
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
35-199 5.75e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 54.89  E-value: 5.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  35 FGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSaLVYGLVAI-GGWLGDKVlGTKRVIMLGAIVLAIGYALVAWSgHDAA 113
Cdd:COG2223   18 FGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPV-LVGALLRIpLGFLVDRF-GPRRVLLIGLLLLGIGLLLLALA-VSYW 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 114 IVYMGMATIAVGNGLFKANPSSLLSTCYDKNdpRLDGAFTMYYMSINIGSFFSMLATPWLAARFGWSVAFALSVVGMVIT 193
Cdd:COG2223   95 LLLLLGLLLGIGGGGSFAVGIALVSKWFPPD--RRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVV 172

                 ....*.
gi 556284588 194 IINFAF 199
Cdd:COG2223  173 AVLAWL 178
MFS_NPF3 cd17415
NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The ...
26-226 8.80e-08

NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF3 is the smallest NPF subfamily and it includes Cucumis sativus nitrite transporter (CsNitr1), now named CsNPF3.2. It functions as a chloroplast nitrite uptake transporter to remove toxic nitrite from the cytosol. NPF3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340973 [Multi-domain]  Cd Length: 448  Bit Score: 54.38  E-value: 8.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  26 IFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALV 105
Cdd:cd17415    7 IFGNEICERLASVGFHTNLITYLTLQLHMPLVKAANILTNFNGTASLTPLLGAFIADSFAGRFWTITIGSIIYQLGMVLL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 106 AWS------------GHDA----------AIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPRLDGA----FTMYYMSI 159
Cdd:cd17415   87 TISailpslrpppcnGHEVcacqassaqlSILYLSLLLTALGSGGIRPCVVAFGADQFDESDPKQAKQtwnfFNWYYFCM 166
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556284588 160 NIGSFFSMLATPWLAARFGWSVAFALSVVGMVITIINFAFCQKWVKQYGSKPDFAPVHMGKLLATIA 226
Cdd:cd17415  167 GIAILLAVTVIVYIQDNVGWGWGFGIPTIAMAISVIAFVVGSPLYRELKSIIRMLPIWAAGILLVTA 233
MFS_SLC15A3_4 cd17348
Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; ...
29-445 1.06e-07

Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 members 3 (SLC15A3) and 4 (SLC15A4) are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They are peptide/histidine transporters (PHTs) that transport free histidine in addition to di/tripeptides. SLC15A4, also called peptide transporter 4 or peptide/histidine transporter 1 (PHT1), is expressed in the human brain, retina, placenta, and immune cells. It is required for Toll-like receptor 7 (TLR7)- and TLR9-mediated type I interferon production in plasmacytoid dendritic cells (pDCs) and is involved in the pathogenesis of lupus-like autoimmunity. SLC15A3, also called osteoclast transporter, peptide transporter 3, or peptide/histidine transporter 2 (PHT2), is expressed in immune tissues including the spleen and thymus. The SLC15A3/SLC15A4 group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340906 [Multi-domain]  Cd Length: 435  Bit Score: 54.03  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  29 IELWERFGYYGLQGIMAVYLVKQ---LGMSEADSITLFssFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALV 105
Cdd:cd17348   10 VELLERAAFYGITSNLVLFLNGSpfnWEGTQASQALLL--FMGATYLLSPFGGWLADAYLGRFWTILLSLLLYLLGMLLF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 106 AWSGhdAAIVYMGMATIAVGNGLFKANPSSL-LSTCYDKNDPRLDGAFTMYYMSINIGSFFSMLATPWLAARFGWSVAFA 184
Cdd:cd17348   88 PATA--APALYAGLLLVGLGVGSVKANITPFgADQVKDRGPEATRRFFNWFYWSINLGAILSLGGVAYIQQNVSFLIGYS 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 185 LSVVGMVITIINFAFcqkwvkqygSKPDFAPVhmgKLLATIAGVVvLVAIATWLLHNQGIARMALGVIALGIVVIFAKEA 264
Cdd:cd17348  166 IPAVCVGLAFLVFLC---------GQPVFIDV---KALVKILPVF-LALIPYWTVYFQMQTTYVLQSLHLKIPNIFISNI 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 265 MGLKGAARRkMIVAFLLMVEAIVFFVLYSQMPTSLNFFAIRNvehsilGLAFEPEQYQALNPFWIMIgSPILAAIYNKmg 344
Cdd:cd17348  233 AGITNSSHT-FPAAWLTMFDAVLILILIPLKDKLVDPFLKRR------GLLPSSLKRIAVGMFFVMC-SAIAAGILES-- 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 345 DRLPMPH-----KFAIGMVLCSGAFLvlplgakfasdagivSVNWLILSYALQSIGELMISGLGLAMVAQLVPQRLMGFI 419
Cdd:cd17348  303 KRLEIVKhnttiQQQIGNVTYYAADL---------------PIWWQIPQYLLIGISEIFASIAGLEFAYSAAPKSMQSAI 367
                        410       420
                 ....*....|....*....|....*.
gi 556284588 420 MGSWFLTTAGAAIIAGKIANLMAVPE 445
Cdd:cd17348  368 MGLFFFFSGVGSFVGSGLLALVSIKE 393
MFS_1 pfam07690
Major Facilitator Superfamily;
35-434 1.09e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 53.58  E-value: 1.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588   35 FGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKvLGTKRVIMLGAIVLAIGYALVAWSGHDAAI 114
Cdd:pfam07690  10 LGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR-FGRRRVLLIGLLLFALGLLLLLFASSLWLL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  115 VYMGMATiAVGNGLFKANPSSLLSTCYDKNdpRLDGAFTMYYMSINIGSFFSMLATPWLAARFGWSVAFALSVVGMVITI 194
Cdd:pfam07690  89 LVLRVLQ-GLGAGALFPAALALIADWFPPE--ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAA 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  195 INFAFcqkwVKQYGSKPDFAPVHMGKLLATIAGVVVLVAIATWLLHnqGIARMALGVIALGIVVIFAKEAMGLKgaarrK 274
Cdd:pfam07690 166 VLLLL----PRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLL--ALLLFGFAFFGLLTYLPLYQEVLGLS-----A 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  275 MIVAFLLMVEAIVFfvlysqmptslnffairnvehsilglafepeqyqalnpfwiMIGSPILAAIYNKMGDRLPMPHKFA 354
Cdd:pfam07690 235 LLAGLLLGLGGLLG-----------------------------------------AIGRLLLGRLSDRLGRRRRLLLALL 273
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  355 IGMVLCSGAFLVlplgakfasdAGIVSVNWLILSYALQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGAAIIA 434
Cdd:pfam07690 274 LLILAALGLLLL----------SLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
42-197 1.40e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 53.34  E-value: 1.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  42 GIMAVYLVKQLGMSEADSITLFSSFSaLVYGLVAI-GGWLGDKVlGTKRVIMLGAIVLAIGYALVAWSgHDAAIVYMGMA 120
Cdd:COG2271   30 SVAAPPLQADLGLSAAQLGLLASAFF-LGYALGQIpAGLLADRF-GRRRVLAIGLLLWGLATLLFGFA-TSFWQLLLLRF 106
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556284588 121 TIAVGNGLFKANPSSLLSTCYDKNDPRLdgAFTMYYMSINIGSFFSMLATPWLAARFGWSVAF-ALSVVGMVITIINF 197
Cdd:COG2271  107 LLGLGEAGFFPAALKLIAEWFPPKERGR--ALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFlILGLPGLLLALLRF 182
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
13-199 1.66e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 53.35  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  13 SLNAFKQPRAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVlGTKRVIM 92
Cdd:cd17325  191 GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-GRKPLIL 269
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  93 LGAIVLAIGYALVAWSGhDAAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNdpRLDGAFTMYYMSINIGSFFSMLATPW 172
Cdd:cd17325  270 IGLLLSAVALLLLPLAT-SFWLLLLLLALLGLGLGLVFPATLALLADIVPPE--GRGTAMGLFNTAFSLGMVLGPLLGGF 346
                        170       180
                 ....*....|....*....|....*..
gi 556284588 173 LAARFGWSVAFALSVVGMVITIINFAF 199
Cdd:cd17325  347 LYDAFGFATPFLAAAALLLLAAVLFLL 373
MFS_NPF7 cd17419
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ...
36-197 1.91e-07

NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340977 [Multi-domain]  Cd Length: 447  Bit Score: 53.53  E-value: 1.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  36 GYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALVAWSGH----- 110
Cdd:cd17419   17 AYFGVGVNLVLYLTRVMHQSNASAANNVSNWTGTVYITPLIGAFLSDSYWGRYWTSTLFQAIFVIGLLLLTLSSAlpslr 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 111 -----------------DAAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPRLDGA----FTMYYMSINIGSFFSMLA 169
Cdd:cd17419   97 ppqcgdgdlkcppasaaQTTFLYFSLYLIALGYGGYQPCIATLGADQFDDEDPIEKASksafFSYFYQALNLGSLFSNTI 176
                        170       180
                 ....*....|....*....|....*...
gi 556284588 170 TPWLAARFGWSVAFALSVVGMVITIINF 197
Cdd:cd17419  177 LVYFEDNGSWGLGFGISAGAAFIGLVLF 204
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
35-195 2.10e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 52.96  E-value: 2.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  35 FGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVlGTKRVIMLGAIVLAIGYALVAWSGHDAAI 114
Cdd:COG2223  219 GSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI-GGRRVLLIVFALMALGLLLLALALGSLWL 297
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 115 VYMGMATIAVGNGLFKANPSSLLSTCYDKNdpRLDGAFTMYYMSINIGSFFSMLATPWLAARFG-WSVAFALSVVGMVIT 193
Cdd:COG2223  298 FLVLFLLLGLALGGGNGAVFALVPDIFPTK--NAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVA 375

                 ..
gi 556284588 194 II 195
Cdd:COG2223  376 LV 377
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
20-197 5.84e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 51.39  E-value: 5.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  20 PRAFYLIFSIELWERFGYYGlqGIMAVYLVKQLGMSEADSITLFSSFSaLVYGLVA-IGGWLGDKVlGTKRVIMLGAIVL 98
Cdd:cd17370  199 PKAFWLYLLAVALFALGNFS--FAFLILRAQELGLSAALIPLLYALFN-LVYALAAyPAGRLSDRI-GRKKLLILGYLSL 274
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  99 AIGYALVAWsGHDAAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNdpRLDGAFTMYYMSINIGSFFSMLATPWLAARFG 178
Cdd:cd17370  275 ALAYLGFAL-GSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAE--LRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS 351
                        170
                 ....*....|....*....
gi 556284588 179 WSVAFALSVVGMVITIINF 197
Cdd:cd17370  352 PSAAFLFSAVLALIALLLL 370
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
39-304 1.71e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 49.97  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  39 GLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKvLGTKRVIMLGAIVLAIGYALVAWSgHDAAIVYMG 118
Cdd:COG2814   27 GIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR-FGRRRVLLLGLLLFALGSLLCALA-PSLWLLLAA 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 119 MATIAVGNGLFKANPSSLLSTCYDKNdpRLDGAFTMYYMSINIGSFFSMLATPWLAARFGWSVAFALSVVGMVITIINFA 198
Cdd:COG2814  105 RFLQGLGAGALFPAALALIADLVPPE--RRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLL 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 199 FC------------QKWVKQYGSKPDFAPVHMGKLLATIAGVVVLVAIATWLLHNQGIARMALGVI--ALGIVVIFAKEA 264
Cdd:COG2814  183 RLlpesrpaararlRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLlaLFGLGGVLGALL 262
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 556284588 265 MGL---KGAARRKMIVAFLLMVEAIVFFVLYSQMPTSLNFFAI 304
Cdd:COG2814  263 AGRladRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFL 305
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
24-441 2.12e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.92  E-value: 2.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  24 YLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKvLGTKRVIMLGAIVLAIGYA 103
Cdd:cd17329    2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADR-FGRKPVMLAGLLLRALGFA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 104 LVAWSgHDAAIVYMGMATIAVGNGLFKANPSSLLSTCYdkNDPRLDGAFTMYYMSINIGSFFSMLATPWLaARFGWSVAF 183
Cdd:cd17329   81 LLGFA-HSPWLFAIALVLTGFGGGLFEPASEAMIADVT--TPENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 184 ALSVVGMVITIINFAFCqkwvkqygsKPDFAPVHMGKLLATIAGvvvlvaiatwllhnqgiarmalgvialgivvifake 263
Cdd:cd17329  157 LAAAVLFLLAALVLLFL---------LPETRPKRRAAEKTEILR------------------------------------ 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 264 amGLKGAARRKMIVAFLLMVeaIVFFVLYSQMPTSLNFFairnVEHSILGLAFEPEQYQALNPFWIMIGSPILAAIYNKM 343
Cdd:cd17329  192 --GYKIVLRDRAFLLFLLAS--FLISLIYFQLESTLPVY----VVEILGLGESLLGLLLALNALLIVLLQFPVARLVERF 263
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 344 GDRLPMphkfAIGMVLCSGAFLVLPLGAKFAsdagivsvnWLILSYALQSIGELMISGLGLAMVAQLVPQRLMGFIMGSW 423
Cdd:cd17329  264 RLRKIL----MIGILLFAIGFAVLAFANTLA---------VLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFY 330
                        410
                 ....*....|....*...
gi 556284588 424 FLTTAGAAIIAGKIANLM 441
Cdd:cd17329  331 ALAWGLGRAIGPLVGGLL 348
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
51-195 4.21e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 49.10  E-value: 4.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  51 QLGMSEAdSITLFSSFSALVYGLVAI-GGWLGDKvLGTKRVIMLGAIVLAIGYALVAWSGhDAAIVYMGMATIAVGNGLF 129
Cdd:COG2807   47 DLGLSAT-QAGLLTTLPLLAFGLFAPlAPRLARR-FGLERTLLLALLLLAAGLLLRSLAP-SVALLLAGTALIGAGIAVG 123
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556284588 130 KANPSSLLSTCYDKndpRLDGAFTMYYMSINIGSFFSMLATPWLAARFGWSVAFALSVVGMVITII 195
Cdd:COG2807  124 NVLLPGLIKRWFPD---RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALL 186
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
221-499 4.31e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 49.13  E-value: 4.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 221 LLATIAGVVVLVAIATWLLHN--QGIARMALGVIALGIVVIF------------AKEAMGLKGAARR-KMIVAFLLMVEA 285
Cdd:COG2211  157 GLGGLLASVLPPPLVAAFGGDaaLGYRLTALIFAVLGLLAFLltffgtkerpvpEEEKVSLKESLKAlLKNRPFLLLLLA 236
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 286 IVFFVLYSQMPTSLNFFAIRNVehsiLGLafePEQYQALNPFWIMIGSPILAAIYNKMGDRLPMPHKFAIGMVLCSGAFL 365
Cdd:COG2211  237 YLLFFLALALVAALLLYYFKYV----LGL---SAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 366 VLPLgakfasdAGIVSVNWLILSYALQSIGELMISGLGLAMVAQLVP-------QRLMGFIMGSW-FLTTAGAAI---IA 434
Cdd:COG2211  310 LLFF-------LGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFtFAIKLGQALagaLA 382
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556284588 435 GKIANLMAVPENVTDPLVSLEVYGHVFLQIGIVTAVIAALMLLTAPKLNRMTQDDSADVKARETA 499
Cdd:COG2211  383 GLLLALFGYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAARRAA 447
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
13-178 5.22e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.74  E-value: 5.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  13 SLNAFKQPRAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKvLGTKRVIM 92
Cdd:COG2211  220 SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR-FGKKKAFI 298
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  93 LGAIVLAIGYALVAWSG-HDAAIVYMGMATIAVGNGLFKANPSSLLSTCYD----KNDPRLDGAFT-MYYMSINIGSFFS 166
Cdd:COG2211  299 IGLLLAALGLLLLFFLGpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewKTGRRREGLYFgIFTFAIKLGQALA 378
                        170
                 ....*....|..
gi 556284588 167 MLATPWLAARFG 178
Cdd:COG2211  379 GALAGLLLALFG 390
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
38-443 6.10e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.58  E-value: 6.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  38 YGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVlGTKRVIMLGAIVLAIGYALVAWSgHDAAIVYM 117
Cdd:cd06174   12 RGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-GRRPVLLLGLLLFALGALLFAFA-PSFWLLLL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 118 GMATIAVGNGLFKANPSSLLSTCYDKndPRLDGAFTMYYMSINIGSFFSMLATPWLAARFGWSVAFALsvvgmvitiinf 197
Cdd:cd06174   90 GRFLLGLGSGLIDPAVLALIADLFPE--RERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVF------------ 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 198 afcqkwvkqygskpdfapvhmgkLLATIAGVVVLVAIATWLLHNQGIARMALGVIALGIVVIFAKEAMGLKGaarrkmiv 277
Cdd:cd06174  156 -----------------------LIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPG-------- 204
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 278 AFLLMVEAIVFFVLYSQMPTSLNFFAIRNVEHSILGLAFepeqYQALNPFWIMIGSPILAAIYNKMGDRLPMphkFAIGM 357
Cdd:cd06174  205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGL----LLSLFGLAGALGSLLLGLLSDRLIGRKPL---LLIGL 277
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 358 VLCSGAFLVLPLGAkfasdagivSVNWLILSYALQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGAAIIAGKI 437
Cdd:cd06174  278 LLMALGLALLLLAP---------SLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLL 348

                 ....*.
gi 556284588 438 ANLMAV 443
Cdd:cd06174  349 AGFLLA 354
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
42-291 1.65e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 46.73  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  42 GIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKvLGTKRVIMLGAIVLAIGYALVAWSgHDAAIVYMGMAT 121
Cdd:COG0477   34 NVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDR-YGRKRVLLIGLLLFGLASLLCGLA-PSPELLIAARAL 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 122 IAVGNGLFKANPSSLLSTCYDKNDPRLdgAFTMYYMSINIGSFFSMLATPWLAARFGWSVAFALSVVGMVITIINFAFCQ 201
Cdd:COG0477  112 QGIGAGGLMPGALALIAELFPARERGR--ALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLP 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 202 KWVKQYGSKPDFAPVHMGKLLATIAGVVVLVAIATWLLHNQGIARMALGVIALGIVVIFAKEAMGLKGAARRKMIVAFLL 281
Cdd:COG0477  190 ESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLL 269
                        250
                 ....*....|
gi 556284588 282 MVEAIVFFVL 291
Cdd:COG0477  270 LLLALLLALL 279
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
51-199 2.01e-04

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 43.77  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  51 QLGMSEADSITLFSSFSALVYGLVAigGWLGDKvLGTKRVIMLGAIVLAIGYALVAWSGHDAAIVYMgMATIAVGNGLFK 130
Cdd:cd17313  277 GAGVRMGAWGLLIFSLAFLIFSLPI--GKLGKK-IGRKKVYLIGLVLFAVGMALMALVHNVTVALVL-FALGGIGWATIN 352
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556284588 131 ANPSSLLSTCYDKNDPRLDGAFTMYYMSINIGSFFSMLATPWLAARFGWSVAFALSVVGMVITIINFAF 199
Cdd:cd17313  353 INPYPLVSDYHSESGRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-163 3.90e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.65  E-value: 3.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588   2 STANNKPAESVSLNAFKQPRAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLG 81
Cdd:COG2814  188 SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLA 267
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  82 DKvLGTKRVIMLGAIVLAIGYALVAWSGHdAAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNdpRLDGAFTMYYMSINI 161
Cdd:COG2814  268 DR-FGRRRLLLIGLLLLALGLLLLALAGS-LWLLLLALFLLGFGFGLLFPLLQALVAELAPPE--ARGRASGLYNSAFFL 343

                 ..
gi 556284588 162 GS 163
Cdd:COG2814  344 GG 345
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
18-195 4.76e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 42.51  E-value: 4.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  18 KQPRAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVlGTKRVIMLGAI- 96
Cdd:cd17369  225 RHWRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRV-GRRPVYLAGALl 303
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  97 --VLAIGYALVAWSGHDAAIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDpRLDGAFTMYYMSINIGSFFSMLATPWLA 174
Cdd:cd17369  304 aaLFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRV-RYTGASLGYQLGAILGGGFAPLIATALV 382
                        170       180
                 ....*....|....*....|....*.
gi 556284588 175 ARFG--WSVA---FALSVVGMVITII 195
Cdd:cd17369  383 AATGswWPVAlylAALAVISLVAALF 408
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
35-195 2.28e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 40.28  E-value: 2.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  35 FGYYGLQGIMAVYLVKQLGMSEADS--ITLFSSFSALVYGLvaIGGWLGDKVlGTKRVIMLGAIVLAIGYALVAWSGHDA 112
Cdd:cd17316  191 FGYYGLTTFLPTYLQTVLGLSPATSslYLLLISLGALVGAL--IAGLLSDRI-GRKKTLVIGLILSGILALPLFYLLSGS 267
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 113 AIVYMGMATIAVGNGLFKANPSSLLSTCYDKNDPRLDGAFTMYYMSINIGSFFSMLATPWLAARFGWSVAFALSVVGMVI 192
Cdd:cd17316  268 PTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIV 347

                 ...
gi 556284588 193 TII 195
Cdd:cd17316  348 ALI 350
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
16-195 3.88e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 39.72  E-value: 3.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  16 AFKQPRAFYLIFSIELWErFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGA 95
Cdd:cd06174  199 VLKNPGLWLLLLAIFLVN-LAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGL 277
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  96 IVLAIGYALVAWSGHDAAIVYMgmaTIAVGNGLFKANPSSLLSTCYDKNDPRLDGAFTMYYMSINIGSFF-SMLATPWLA 174
Cdd:cd06174  278 LLMALGLALLLLAPSLLLLLLL---LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIgPLLAGFLLA 354
                        170       180
                 ....*....|....*....|.
gi 556284588 175 ARFGWSVAFALSVVGMVITII 195
Cdd:cd06174  355 ATFGLTGAFLVLAVLLLLAAI 375
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
42-199 4.13e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 39.48  E-value: 4.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  42 GIMAVYLVKQLGMSEADSITLFSSFSaLVYGLVAI-GGWLGDKVlGTKRVIMLGAIVLAIGYALVAWsghdaAIVYMGMA 120
Cdd:cd17319   23 SVAAPTIMKDLGLSPTQYGLIASAFF-LGYALFQVpGGWLLDRF-GARKVLAVSMLLWSLFTALTGF-----ATSLTSLY 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588 121 TIAVGNGLFKA--NPSSLLSTCYDKNDPRLDGAFTMYYMSINIGSFFSMLATPWLAARFGWSVAF-ALSVVGMVITIINF 197
Cdd:cd17319   96 VLRFLLGVAEAgfFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFiIEGLLGLLLAVLWW 175

                 ..
gi 556284588 198 AF 199
Cdd:cd17319  176 FY 177
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
3-195 4.83e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.45  E-value: 4.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588   3 TANNKPAESVSLNAFKQPRAFYLIFSIelwerFGYYGLQGIM----AVYLVKQLGMSEADSITLFSSFSALVYGLVAIGG 78
Cdd:COG0738  193 EEEAAGSAASLKSLLKNPRLLLGGLAI-----FLYVGAEGAIgdwlPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGG 267
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  79 WLGDKVlGTKRVIMLGAIVLAIGYALVAWSGHDAAIVYmGMATIAVGNGLFKANPSSLLSTCYDKNDPRLDGAFTMyyMS 158
Cdd:COG0738  268 FLLKRF-GPVRLLRLSALLAAVGLLLALLAPGPWLALI-GLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLI--MG 343
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 556284588 159 InIGSFFSMLATPWLAARFGWSVAFALSVVGMVITII 195
Cdd:COG0738  344 I-VGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILL 379
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
1-199 7.29e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 7.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588   1 MSTANNKPAESVSLNAFKQPRAFYLIFSIELWERFGYYGLQgIMAVYLVKQLGMSEADSITLFSSFSALVyglVAIGGWL 80
Cdd:cd17473  177 ARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIP-IQLPFLLQERGGGSAALIGLALAIASLA---GAIGALL 252
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  81 GDKV---LGTKRVIMLGAIVLAIGYALVAWSgHDAAIVYMGMATIAVGNGLFKANPSSLLStcyDKNDPRLDGAFTMYY- 156
Cdd:cd17473  253 FGRLkrrLGKRRLLAIGFALMALGFLLLALA-SGLWVVLLGAILAGLGFGLLLPTLNSWAM---SLVPPELRGRAMGIVt 328
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 556284588 157 MSINIGSFFS-MLATPWLAARFGWSVAFALS-VVGMVITIINFAF 199
Cdd:cd17473  329 SAFFLGQFLSpLVLGPLVNLTGGLSGAFLILgVLALVLAIVLLLL 373
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
42-137 8.35e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 38.36  E-value: 8.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556284588  42 GIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKvLGTKRVIMLGAIVLAIGYALVAWSGHdAAIVYMGMAT 121
Cdd:cd17353   23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDR-GGPRKAILIGGILFGLGFILSAFAIS-LPLLFLGYGV 100
                         90
                 ....*....|....*..
gi 556284588 122 IA-VGNGLFKANPSSLL 137
Cdd:cd17353  101 LGgIGAGIGYITPVSTA 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH