|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
33-430 |
8.34e-95 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 290.78 E-value: 8.34e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 33 IGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAV 112
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 113 GLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLFVSVGVVGIL 192
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 193 FALVWWRCYREPHEDPRLSQQEREHIENGGGLSAPADQQV-AFSWPLVRQLLSKRQIIGASIGQFAGNTVLVFFLTWFPT 271
Cdd:TIGR00893 161 WGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPsTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 272 WLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLLKATGSANLGRKLPIVAGLLMASCIISANWLQSDLAVILVMS 351
Cdd:TIGR00893 241 YLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVNIPYAALALVA 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556285271 352 FAFFGQGMVGLGWTLISDIAPKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGNFFYALIYIGGAALLGVAAYLFIL 430
Cdd:TIGR00893 321 LGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGALSYLLLV 399
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
24-429 |
2.07e-89 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 275.60 E-value: 2.07e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 24 RIGILALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSL 103
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 104 FTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLF 183
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 184 VSVGVVGILFALVWWRCYrephedprlsqqerehienggglsapadqqvafswplvrqllskRQIIGASIGQFAGNTVLV 263
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL--------------------------------------------RQVWGLALGYFGINYALY 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 264 FFLTWFPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLLkatgsaNLGRKLPIVAGLLMASCIISANWL-QS 342
Cdd:cd17319 197 GLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLL------RGARRLVIIIGLLLAAVGLLLAYLtTS 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 343 DLAVILVMSFAFFGQGMV-GLGWTLISDIAPKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGNFFYALIYIGGAALL 421
Cdd:cd17319 271 PVVAVILLSLAGFGIGAAsPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALL 350
|
....*...
gi 556285271 422 GVAAYLFI 429
Cdd:cd17319 351 AALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-435 |
3.21e-66 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 215.89 E-value: 3.21e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 17 TARRSRRRIGILALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFL 96
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 97 SLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDG 176
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 177 FGWRVLFVSVGVVGILFALVwwrcyrephedprlsqqerehienggglsapadqqvafswplvrqllskrQIIGASIGQF 256
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL--------------------------------------------------RFWLLALAYF 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 257 AGNTVLVFFLTWFPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLLKAtgsanlGRKLPIVAGLLMASCIIS 336
Cdd:COG2271 191 LVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR------RKLVLAIGLLLAALALLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 337 ANWLQSDLAVILVMS-FAFFGQGMVGLGWTLISDIAPKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGnFFYALIYI 415
Cdd:COG2271 265 LALLPSPALAIALLFlAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLL 343
|
410 420
....*....|....*....|
gi 556285271 416 GGAALLGVAAYLFILGDVKR 435
Cdd:COG2271 344 AALALLAALLALLLLRETRK 363
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
33-406 |
8.03e-59 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 197.21 E-value: 8.03e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 33 IGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAV 112
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 113 GLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPL-LFWIMDGFGWRVLFVSVGVVGI 191
Cdd:TIGR00881 82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLvLFGIAELYSWHWVFIVPGIIAI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 192 LFALVWWRCYREPHEDPRLSQQEREHIENGGGLSAPADQQVAFSWPLVRQLLSKRQIIGASIGQFAGNTVLVFFLTWFPT 271
Cdd:TIGR00881 162 IVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 272 WLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLLKAT-GSANLGRKLPIVAGLLMASCIISANWLqsdLAVILVM 350
Cdd:TIGR00881 242 YLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRrGPLAVFFMALIIVSLLVYWLNPAANPL---MDLICLF 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 556285271 351 SFAFFGQGMVGLGWTLISDIAPKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFG 406
Cdd:TIGR00881 319 ALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
29-428 |
3.62e-46 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 163.11 E-value: 3.62e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 29 ALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFH 108
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 109 GMA--VGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLFVSV 186
Cdd:cd17380 82 PLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 187 GVVGILFALVWWRCYREphedprlsqqerehienggglsapadqqvafSWPLVrqllskrqiigasIGQFAGNTVLVFFL 266
Cdd:cd17380 162 GLLGLLWALVWLIYLPP-------------------------------VWAII-------------VAHFCMNWGFYILL 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 267 TWFPTWLaTERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLLKATGSANLGRKLPIVAGLL-MASCIISANWLQSDLA 345
Cdd:cd17380 198 SWLPTYF-HEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLgPALFLLLLSHTDSFSL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 346 VILVMSFAFFGQGMVGLGWTL-ISDIAPKgLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGNFFYALIYIGGAALLGVA 424
Cdd:cd17380 277 ALLCMSVALGLSAFSSSGVLVnHQDIAPN-YAGIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVGAV 355
|
....
gi 556285271 425 AYLF 428
Cdd:cd17380 356 VFLL 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
22-437 |
9.27e-44 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 157.74 E-value: 9.27e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 22 RRRIGILALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLW 101
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 102 SLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRV 181
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 182 LFVSVGVVGILFALVWWRCYREPHEDPRLSQQErehienggglsapadqqvafSWPLVRQLLSKRQIIGASIGQFAGNTV 261
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDPPAGAAAAAKA--------------------SLRDQLEALRDPRFWLLSLLYFGTFGS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 262 LVFFLTWFPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLlkatgsanLGRKLPIVAGLLMASCIISANWLQ 341
Cdd:COG2223 221 FIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI--------GGRRVLLIVFALMALGLLLLALAL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 342 SD--LAVILVMSFAFFGQGMVGLGWTLISDIAPKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGNFFYALIYIGGAA 419
Cdd:COG2223 293 GSlwLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLA 372
|
410
....*....|....*...
gi 556285271 420 LLGVAAYLFILGDVKRIE 437
Cdd:COG2223 373 LVALVLTLLLYRRPRRAA 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
18-393 |
1.97e-34 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 131.25 E-value: 1.97e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 18 ARRSRRRIGILALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLS 97
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 98 LTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGF 177
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 178 GWRVLFVSVGVVGILFALVWWRCYREPHEDPRLSQQERehienggglsapadqqvafswplVRQLLSKRQIIGASIGQFA 257
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS-----------------------LRELLRRPRLLLLLLLAFL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 258 GNTVLVFFLTWFPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLLKatgsanlgRKLPIVAGLLMASCIISA 337
Cdd:COG2814 219 LGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR--------RRLLLIGLLLLALGLLLL 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 556285271 338 NWLQSDLAVILVMSFAFFGQGMV-GLGWTLISDIAPKGLGGLTGGLFNFCANLAGIL 393
Cdd:COG2814 291 ALAGSLWLLLLALFLLGFGFGLLfPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
30-420 |
4.14e-33 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 128.51 E-value: 4.14e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 30 LLAIGTMINYLDRTVLGIA----------------------APKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDR 87
Cdd:cd17318 3 LLFLGFAVVYAMRVNLSVAivamvnstathdnnntstdkdtLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 88 FGNKVTYFLSLTLWSLFTLFHGMAV--GLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLAC 165
Cdd:cd17318 83 YGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 166 FAPLLFWIMDGFGWRVLFVSVGVVGILFALVWWRcyrephedprlsqqerehiengggLSAPAdqqvafsWPLVrqllsk 245
Cdd:cd17318 163 AMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFF------------------------LVLPV-------WAIV------ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 246 rqiigasIGQFAGNTVLVFFLTWFPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLL-KATGSANLGRKLPI 324
Cdd:cd17318 206 -------VAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRsRGILSTTTVRKLFT 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 325 VAGLLMAS-CIISANWLQSDlaVILVMSFAFFGQGMVGLGWTLIS----DIAPKGLGGLTGGLfNFCANLAGILTPLVIG 399
Cdd:cd17318 279 SIGFLGPGvFLIALGYLGSN--ATLAVVFLTLSVGLSGACYSGFLvnhlDLAPNYAGTLMGIT-NTAATIAGIISPLIVG 355
|
410 420
....*....|....*....|....*....
gi 556285271 400 FIV------AGFGNFFY--ALIYIGGAAL 420
Cdd:cd17318 356 AIVkndqtiGQWRIVFFisAAIYILGAIF 384
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
31-395 |
5.49e-31 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 121.76 E-value: 5.49e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 31 LAIGTMINYLDRTVLGIAAPK-LTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHG 109
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 110 MAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLFVSVGVV 189
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 190 GILFALVWWRcYREPHEDPRLSQQEREHIENGGGLSApadqqvafswplvrqlLSKRQIIGASIGQFAGNTVLVFFLTWF 269
Cdd:pfam07690 161 SLLAAVLLLL-PRPPPESKRPKPAEEARLSLIVAWKA----------------LLRDPVLWLLLALLLFGFAFFGLLTYL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 270 PTWlATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLlkatgSANLGRKLPIVAGLLMASCIISANWLQSDLAVILV 349
Cdd:pfam07690 224 PLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL-----GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLA 297
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 556285271 350 MSFAFFGQGMV-GLGWTLISDIAPKGLGGLTGGLFNFCANLAGILTP 395
Cdd:pfam07690 298 LLLLGFGFGLVfPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
31-427 |
6.77e-30 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 119.45 E-value: 6.77e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 31 LAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGM 110
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 111 AVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMD--GFGWRVLFVSVGV 188
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 189 VGILFALVWWRCYREPHEDPRLSQQEREHienggglsapadqqvAFSWPLVRQLLSKRQIIGASIGQFAGNTVLVFFLTW 268
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASS---------------KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 269 FPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLLKatgsanLGRKLPIVAGLLMASCIISANWLQSDLAVIL 348
Cdd:cd06174 226 LPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG------RKPLLLIGLLLMALGLALLLLAPSLLLLLLL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556285271 349 VMSFAFFGQGMVGLGWTLISDIAPKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGNFFYALIYIGGAALLGVAAYL 427
Cdd:cd06174 300 LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
50-430 |
6.77e-28 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 113.83 E-value: 6.77e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 50 PKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEA 129
Cdd:cd17325 20 PLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 130 PCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLFVSVGVVGILFALVWWRCYREPHEDPR 209
Cdd:cd17325 100 AVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 210 lsqqerehienggglsaPADQQVAFSWPLVRQLLSKRQIIGASIGQFAGNTVLVFFLTWFPTWLATERHMPWLKVGFFSI 289
Cdd:cd17325 180 -----------------KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 290 LPFVAAAGGVMFGGWISDKllkatgsanLGRKLPIVAGL-LMASCIISANWLQSDLAVILVMSFAFFGQGMVGLGW-TLI 367
Cdd:cd17325 243 AQGLASALSQPPAGKLSDR---------IGRKPLILIGLlLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATlALL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556285271 368 SDIAPKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGnfFYALIYIGGAALLGVAAYLFIL 430
Cdd:cd17325 314 ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG--FATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
28-427 |
2.45e-25 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 106.94 E-value: 2.45e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 28 LALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLF 107
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 108 HGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMD-GFGWRVLFVSV 186
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 187 GVVGILFALVWWRCYREPHedprlsqqeREHIENGGGLSAPADQqvafSWPLVRQLLSKRQIIGASIGQFAGNTVLVFFL 266
Cdd:cd17328 161 GVLGVLLAILLLLFVREPP---------RGAAEGGVMAKSTATS----FLADLKALAKNPSFILSTLGFTAVSFVTGALA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 267 TWFPTWLATERHMPWLK----VGFFSILPFVAAAGGVMFGGWISDKLLKATGSANlgrklPIVAGLLMASCI----ISAN 338
Cdd:cd17328 228 FWAPTFFLRAFGVGDLSsadvGLIFGAITCIAGVLGVLLGGILADRLRRKTPRAD-----PLVCAVGLLAAApflfLALV 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 339 WLQSDLAVILVMsfAFFGQGMVGLGWTLISDIA-----PKGLGGLTGGLFNFCANLAGILTPLVIGFI-----------V 402
Cdd:cd17328 303 LALSNLLLAWVL--LFLGEFLLSLNWAPVFAILlyvviPTRRSTASAIQILLSHLLGDAGSPYLIGLIsdllrqnkdspL 380
|
410 420
....*....|....*....|....*
gi 556285271 403 AGFGNFFYALIYIGGAALLGVAAYL 427
Cdd:cd17328 381 AEAASLQYALLLCSFVLVLGGFFFL 405
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
45-428 |
2.21e-24 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 103.86 E-value: 2.21e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 45 LGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGL 124
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 125 GVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLFVSVGVVGILFALVWWRCYREP 204
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 205 HEDPRLSQQEREhienggglsapadqqvafSWPLVRQLLSKRQIIGASIGQFAGNTVLVFFLTWFPTWLATERHMPWLKV 284
Cdd:cd17475 175 PAASAATESAST------------------LLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 285 GFFSILPFVAAAGGVMFGGWISDKLLKATgsanlgRKLPIVAGLLMASCIISANWLQSD-----LAVILVMSFAFFGQGM 359
Cdd:cd17475 237 GALLAVAQLGGALGRIGLGRVSDRVFGGR------RRPVLVITAAIAAAALLVLSLLSPgtplwLLVLLLILLGLFAIGW 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556285271 360 VGLGWTLISDIAPKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGNffYALIYIGGAALLGVAAYLF 428
Cdd:cd17475 311 NGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHS--YAPAWLALALLLVLAALLL 377
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
50-429 |
1.02e-23 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 101.86 E-value: 1.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 50 PKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEA 129
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 130 PCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLFVSVGVVGILFALVWWRcyrephedpR 209
Cdd:cd17324 103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWR---------L 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 210 LSQQEREHIENGGGLSAPadqqvafswplvRQLLSKRQIIGASIGQFAGNTVLVFFLTWFPTWLATERHMPWLKVGFFSI 289
Cdd:cd17324 174 LPSLPPKKPGSLGLLSSL------------LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 290 LPFVAAAGGVMFGGWISDKLLKatgsanlgRKLPIVAGLLMASCIISANWLQSDLAVILVMSFAFFGQGMVGLGW-TLIS 368
Cdd:cd17324 242 LFGVAGVVGSPLAGRLADRGGR--------RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALqTRVL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556285271 369 DIAPKgLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGnffYALIYIGGAALLGVAAYLFI 429
Cdd:cd17324 314 RLAPE-ARGLASSLYLAAYNLGGALGAALGGLVLDHGG---WAGVGWVGAALLLLALLLAL 370
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
24-427 |
1.90e-20 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 92.34 E-value: 1.90e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 24 RIGILALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSL 103
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 104 FTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLF 183
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 184 VSVGVVGILFALVWWRCYREphEDPRLsqqerehienggglsapadqqvafsWPLvrqllskrqiigaSIGQFAGNTVLV 263
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRD--SPPYV-------------------------WVL-------------SLAYAFVYIVRY 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 264 FFLTWFPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLLKATgsanlgRKLPIV---AGLLMASCIISANWL 340
Cdd:cd17312 201 ACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGR------RAPIAViymLLMTLSLALFWFFPH 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 341 QSDLAVILVMSFAFFGQGMVGLGWTLIS-DIAPKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGnFFYALIYIGGAA 419
Cdd:cd17312 275 NKLLSIVLLFLIGFFVGGPINLIGGAAAqDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYG-WSTVFYFLISAA 353
|
....*...
gi 556285271 420 LLGVAAYL 427
Cdd:cd17312 354 LLSVLLLL 361
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
17-305 |
2.62e-19 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 87.94 E-value: 2.62e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 17 TARRSRRRIGILALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFL 96
Cdd:COG0477 5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 97 SLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLAcFAPLLF-WIMD 175
Cdd:COG0477 85 GLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLA-LGPLLGgLLVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 176 GFGWRVLFVSVGVVGILFALVWWRCyrepHEDPRLSQQEREHIENGGGLSAPADQQVAFSWPLVRQLLSKRQIIGASIGQ 255
Cdd:COG0477 164 ALGWRWIFLINAPLGLLALVLRLRL----PESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAAL 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 556285271 256 FAGNTVLVFFLTWFPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWI 305
Cdd:COG0477 240 LLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLL 289
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
28-427 |
4.27e-19 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 88.04 E-value: 4.27e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 28 LALLAIGTMINYLDRTVLGIAAPKL--TGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFT 105
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLaaEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 106 LFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIM----DGFGWRV 181
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIpllsGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 182 LFVsVGVVGILFALVWWRcyrephedprlsqqerehienggglsapadqqvafswplvrqllskrQIIGASIGQFAGNTV 261
Cdd:cd17316 161 LFL-IGALPALLALLLRR-----------------------------------------------RTLLLILLWFFISFG 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 262 LVFFLTWFPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKllkatgsanLGRKLPIVAGLLMASC--IISANW 339
Cdd:cd17316 193 YYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR---------IGRKKTLVIGLILSGIlaLPLFYL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 340 LQSDLAVILVMSF--AFFGQGMVGLGWTLISDIAPKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGNFFYALIYIGG 417
Cdd:cd17316 264 LSGSPTLLLLLLFilSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILAL 343
|
410
....*....|
gi 556285271 418 AALLGVAAYL 427
Cdd:cd17316 344 LAIVALIVAL 353
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
27-395 |
1.12e-18 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 87.30 E-value: 1.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 27 ILALLAIGTMINYLDRTVLGIAA----PKLTGELGIDPALMGILFSAfawTYALAQIPGGLFLDRFGNKVTYFLSLTLWS 102
Cdd:cd17327 6 ILPLLCILYFLQYLDKSNISNAAvmgmKEDLKLVGNQYNWGNTVFYV---GYIIFELPGNLLLQRFPPSKWLSVFIVLWG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 103 LFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLAcFAPLL---FWIMDGF-- 177
Cdd:cd17327 83 LLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSI-FGGLLaygVFKILGVgg 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 178 --GWRVLFVSVGVVGILFALVWWRCYREPHEDPR-LSQQEREHI-----ENGGGLSAPadqqvAFSWPLVRQLLSKRQII 249
Cdd:cd17327 162 laGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWfLTEEEKELAverlrANQTGKGDQ-----KFKWKQIKEAFKDPRTW 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 250 GASIGQFAGNTVLVFFLTWFPTWLATERHMPwLKVGFFSILPFVAAAGGVMFGGWISDKllkatgsanLGRKLPIVAG-- 327
Cdd:cd17327 237 LLFLFFFCSQITNNGISNFLPLILKSLGFYS-LQTNLLSVPIGALGAVSLLIAALLSDR---------FKKRGLFAIFac 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 328 -LLMASCIISANWLQSDLAVILVMSFAFFGQGMVGLGWTLISDI-APKGLGGLTGGLFNFCANLAGILTP 395
Cdd:cd17327 307 vLALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNcAGYTKRATVLAIMLIFYNVGNIVAP 376
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
60-401 |
2.96e-18 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 86.72 E-value: 2.96e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 60 PALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMA--VGLKTLLLCRFGLGVSEAPCFPVNSR 137
Cdd:TIGR00894 75 GALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAagGGIALVVFCRVIQGLAQGSVSPATHK 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 138 VVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMD-GFGWRVLFVSVGVVGILFALVWwrcYREPHEDPRLSQQERE 216
Cdd:TIGR00894 155 IIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCEsWGGWPMIFYVFGIVGCAWSLLW---FVFPADDPSIHPCISK 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 217 HIENGGGLSApADQQVAFSWPL-VRQLLSKRQIIGASIGQFAGNTVLVFFLTWFPTWLATERHMPWLKVGFFSILPFVAA 295
Cdd:TIGR00894 232 FEKKYINSSL-QGQKGSTRQSLpIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFA 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 296 AGGVMFGGWISDKLL-KATGSANLGRKL-PIVAGLLMASCIISANWLQSD--LAVILVMSFAFFGQGMVGLGWTLISDIA 371
Cdd:TIGR00894 311 WLCSIFAGYLADFLKsSKTLSLTAARKIfNGIGGLGPGIFAYALPYLSAAfyLTIIILTLANAVSSGPLAGVLINSLDLA 390
|
330 340 350
....*....|....*....|....*....|
gi 556285271 372 PKGLGGLTGGLFnFCANLAGILTPLVIGFI 401
Cdd:TIGR00894 391 PRFLGFIKGITG-LPGFIGGLIASTLAGNI 419
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
50-430 |
5.15e-18 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 85.31 E-value: 5.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 50 PKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEA 129
Cdd:cd17474 23 PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 130 PCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLAcFAPLLFWIMDGFGWRVLFVSVGVVGILFALVWWRCYREPHEdpr 209
Cdd:cd17474 103 GLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIA-VGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKE--- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 210 lsqqerehienggglsaPADQQVAFSWPLVRQLLSKRQIIGASIGQFAGNTVLVFFLTWFPTWLATERHMPWLKVGFFSI 289
Cdd:cd17474 179 -----------------KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 290 LPFVAAAGGVMFGGWISDKllkatgsANLGRKLPIVAGLLMASCIISANWLQSDLAVILVMSFAFFGQGMV-GLGWTLIS 368
Cdd:cd17474 242 GWSVLLALGSLFVGRLLKK-------RFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNlPLLTTLVT 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556285271 369 DIAPKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGnfFYALIYIGGAALLGVAAYLFIL 430
Cdd:cd17474 315 ELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG--LSAPFLVGAAIALAAAVLLALL 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
21-402 |
5.33e-18 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 85.49 E-value: 5.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 21 SRRRIGILALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTL 100
Cdd:TIGR00895 12 SRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 101 WSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWR 180
Cdd:TIGR00895 92 FSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 181 VLFVSVGVVGILFALVWWRCYREPHEdprlSQQEREHIENGGGLSAPADQQVAFSWPLVRQLLSKRQIIGASI-----GQ 255
Cdd:TIGR00895 172 SLFYVGGIAPLLLLLLLMRFLPESID----FLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFkalfqGK 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 256 FAGNTVL-----------VFFLT-WFPTwLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKL-LKATGSanlgrkL 322
Cdd:TIGR00895 248 TARITVLlwllyfmllvgVYFLTnWLPK-LMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLgPRVTAL------L 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 323 PIVAGLLmaSCIISANWLQSDLAVILVMSFAFFGQGMVGLGWTLISDIAPKGLGGLTGGLFNFCANLAGILTPLVIGFIV 402
Cdd:TIGR00895 321 LLLGAVF--AVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
11-429 |
1.85e-17 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 83.77 E-value: 1.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 11 AAQPAVTARRSRRRIGILALLAIGTMINY-LDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFG 89
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLrPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 90 NKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQeRAKATAVYTVGEYLGLACFAPL 169
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 170 LFWIMDGFGWRVLFVSVGVVGILFALVWWRCYREPHEDPRLSQQErehienggglsapadqqvafswPLVRQLLSKRQII 249
Cdd:COG2807 161 TVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAA----------------------ASLRSLWRSPLAW 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 250 GASIGQFAGNTVLVFFLTWFPTWLaTERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLlkatgsanLGRKLPIVAGLL 329
Cdd:COG2807 219 LLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRL--------GDRRPLLLLLGL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 330 MASCIISANWLQSDLAVILVMSFAFFGQGMV-GLGWTLISDIAPKGLGGLTGGLF-NFCANLAGILTPLVIGFIVAGFGN 407
Cdd:COG2807 290 LGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLfPLALTLIGLRARTPAEAAALSGMaQSVGYLLAALGPLLVGALHDATGS 369
|
410 420
....*....|....*....|..
gi 556285271 408 FFYALIYIGGAALLGVAAYLFI 429
Cdd:COG2807 370 WTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
31-371 |
9.69e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 78.37 E-value: 9.69e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 31 LAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGM 110
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 111 AVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLAcFAPLLF-WIMDGFGWRVLF---VSV 186
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAA-LGPLLGgLLLELFGWRWIFlinVPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 187 GVVGILFAlvwwrcyrephedprlsqqerehienggglsapadqqvafswplvrqllskRQIIGASIGQFAGNTVLVFFL 266
Cdd:cd17321 160 GLVALLLA---------------------------------------------------RTFSGAVLAAFLLGAALGGLL 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 267 TWFPTWLATERHMPWLKVGFFsilpFVAAAGGVMFGGWISDKLLKATGSanlgrKLPIVAGLLM--ASCIISANWLQSDL 344
Cdd:cd17321 189 FLLPLYLQGVLGYSPLQAGLA----LLPLALAMLVAAPLAGRLADRFGP-----RLVLVAGLLLtaVGLLLLALLGADSS 259
|
330 340
....*....|....*....|....*..
gi 556285271 345 AVILVMSFAFFGQGMvGLGWTLISDIA 371
Cdd:cd17321 260 VWLLLPGLVLLGLGL-GLFATPLTNAA 285
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
21-427 |
2.34e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 74.12 E-value: 2.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 21 SRRRIGILALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTL 100
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 101 WSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAK---ATAVYTVGEYLGLACFAPLLFWIMdGF 177
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRlnlLHAFFSLGALLGPLLGGLLILLGL-SL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 178 GWRVLFVSVGVVGILFALVWWRCyrephedpRLSQQEREHIENGGGLSAPadqqvafswplvRQLLSKRQIIGASIGQFA 257
Cdd:COG0738 162 SWHLPYLILAVLLLLLALLFLRS--------KLPEIEEEEEEAAGSAASL------------KSLLKNPRLLLGGLAIFL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 258 GNTVLVFFLTWFPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLlkatgsaNLGRKLPIVAGLLMASCIISA 337
Cdd:COG0738 222 YVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-------GPVRLLRLSALLAAVGLLLAL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 338 NWLQSDLAVILVMSFAFFGQGMVGLGWTLISDIAPKgLGGLTGGLFNFCANLAGILTPLVIGFIVAGFG-NFFYALIYIG 416
Cdd:COG0738 295 LAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGK-RTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGlRAAFLVPLVC 373
|
410
....*....|.
gi 556285271 417 GAALLGVAAYL 427
Cdd:COG0738 374 YLLILLLALAL 384
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
24-430 |
4.45e-14 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 73.43 E-value: 4.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 24 RIGILALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSL 103
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 104 FTLFHGMAVGLKT--------LLLCRFGLGVSEAPCFpvnsRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMD 175
Cdd:cd17345 81 INILIGFVPSATSsvglmfilLFLNGWFQGMGWPPSG----RTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 176 GFG---WRVLFVSVGVVGILFALVWWRCYREPHEDPRLSQQErEHIENGGGLSAPADQQVAFSwplVRQLLSKRQIIGAS 252
Cdd:cd17345 157 IFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIE-EYKGDYPEEADGEEEEQELS---AWEIFVKYVLKNKL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 253 IGQFAGNTVLVFF-----LTWFPTWLATERHMPwLKVGFFSILPF-VAAAGGVMFGGWISDKLLKatgsanlGRKLPI-V 325
Cdd:cd17345 233 LWYIAIANVFVYLvrygiLDWAPTYLSEVKGFS-KAQAMWAFSLFeWAAIPGTLLAGWLSDKLFK-------GRRAPTgI 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 326 AGLLMASCIISANWLQS----DLAVILVMSFAFFG-QGMVGLgwtLISDIAPKGLGGLTGGLFNFCANLAG-ILTPLVIG 399
Cdd:cd17345 305 IFMILVIVALIVYWLAPnvlvDLIALIALGFLIYGpVMLIGL---QALELVPKKAAGTAAGLTGLFGYLGGsVLATALIG 381
|
410 420 430
....*....|....*....|....*....|.
gi 556285271 400 FIVAGFGnFFYALIYIGGAALLGVAAYLFIL 430
Cdd:cd17345 382 IIVDHFG-WNGGFIVLLASCILAIIFLALVA 411
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
55-430 |
2.23e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 71.09 E-value: 2.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 55 ELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPV 134
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 135 NSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLFVSVGVVGILFALVWWRCYREPHEDPRLSQQE 214
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 215 RehienggglsapadqqvafswPLVRQLLSKRQIIGASIGQFAGNTVLVfFLTWFPTWLateRHMPWLKVGFFsilpFVA 294
Cdd:cd17489 185 T---------------------RAFRRLVEKKVLPPALILFLASIAYGA-ISTFLPLYA---AERGISNAGLF----FTV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 295 AAGGVMFGGWISDKLLKAtgsanLGRKLPIVAGLLMASCIISANWLQSDLAVILVmSFAFFGQG----MVGLGwTLISDI 370
Cdd:cd17489 236 YAIALLLSRPFSGKLSDR-----KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLL-AAVLYGLGfgllFPALQ-ALAVDL 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 371 APKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGnffYALIYIGGAALLGVAAYLFIL 430
Cdd:cd17489 309 VPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG---YRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
32-431 |
9.06e-13 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 69.25 E-value: 9.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 32 AIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMA 111
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 112 VGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAV----YTVGeYLGLACFAPLLF-WIMDGFGWRVLFvsv 186
Cdd:cd17371 85 QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYvqsgWAVG-WLLATLLAALLFpLLPPEIAWRVLF--- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 187 gVVGILFALVWWRCYREPHEDPRLSQQEREHIENGgglsAPADQQVAFSWPLVRQLLSKRQIIGASIGQFAGNTvlvffl 266
Cdd:cd17371 161 -LLGALPALLVLFIRRFVKEPPQWQAARAARRHFA----DRPSLRELFSPPLLRTTLLASLLATGALGGYYGIT------ 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 267 TWFPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKllkatgsanLGRKLPIVAG-LLMASCIISANWLQSDLA 345
Cdd:cd17371 230 TWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADR---------IGRRNNFALFaLGSAISILLYFFLPLSPT 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 346 VILVMSFA--FFGQGMVGLGWTLISDIAPKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGnffyaliyIGGAALLGV 423
Cdd:cd17371 301 LILILGFPlgFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGS--------LGTAIAVFA 372
|
....*...
gi 556285271 424 AAYLFILG 431
Cdd:cd17371 373 AVYYIAGL 380
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
28-195 |
5.30e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 66.84 E-value: 5.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 28 LALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLF 107
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 108 HGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLFVSVG 187
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
....*...
gi 556285271 188 VVGILFAL 195
Cdd:cd17365 161 VPPLILLP 168
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-431 |
4.68e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 64.54 E-value: 4.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 14 PAVTARRSRRRIGILALLAIGTMINYLdrTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLD----RFG 89
Cdd:COG2211 1 TAAKKKLSLKEKLAYGLGDLGLNLAFG--LLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 90 NKVTYFL------SLTLWSLFTLFH-----GMAVGLKTLLLCRFGLGVSEAPcfpvnsrvVSAWFP-----QQERAKATA 153
Cdd:COG2211 79 RRRPWILigaiplALSFVLLFTAPDlsptgKLIYALVTYLLLGLAYTLVNIP--------YSALGAeltpdYEERTRLSS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 154 VYTVGEYLGLACFAPLLFWIMDGF------GWRVLFVSVGVVGILFALVWWRCYREPHedprlsqqerehienggglsAP 227
Cdd:COG2211 151 WRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERP--------------------VP 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 228 ADQQVAFsWPLVRQLLSKRQIIGASIGQFAGNTVLVFFLTWFPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISD 307
Cdd:COG2211 211 EEEKVSL-KESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAK 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 308 KLlkatgsanlGRKLPIVAGLLMASCIISANWL---QSDLAVILVMSFAFFGQGMV-GLGWTLISDIAPKGLGGLTGGL- 382
Cdd:COG2211 290 RF---------GKKKAFIIGLLLAALGLLLLFFlgpGNLWLLLVLAALAGIGLGAIlVLPWAMLADVVDYDEWKTGRRRe 360
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 556285271 383 ------FNFCANLAGILTPLVIGFIVAGFGnfFYALIYIGGAALLGVAAYLFILG 431
Cdd:COG2211 361 glyfgiFTFAIKLGQALAGALAGLLLALFG--YVAGAAQSPSALTGIRLLFFLLP 413
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
60-428 |
4.93e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 64.13 E-value: 4.93e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 60 PALMGILFSAFAwtyalaqipgGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVV 139
Cdd:cd17473 44 PALFIALFAPLA----------GWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 140 SAWFPQQERAKATAVYTVGEYLGlACFAPLLFWIMDGFGWRVLFVSVGVVGILFALVWWrCYREPhedprlsqqerehie 219
Cdd:cd17473 114 GDYFEGEERAKMLGLQSAAMSLG-GVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLL-FLPEP--------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 220 nggglsAPADQQVAFSWPLVRQLLSKRQIIGASIGQFAGNTVLVFFLTWFPTWLATERHMPWLKVGFFSILPFVAAAGGV 299
Cdd:cd17473 177 ------ARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 300 MFGGWISDKLLKatgsanlgRKLPIVAGLLMASCIISANWLQSDLAVILVMSFAFFGQGMVG-LGWTLISDIAPKGLGGL 378
Cdd:cd17473 251 LLFGRLKRRLGK--------RRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLpTLNSWAMSLVPPELRGR 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 556285271 379 TGGLFNFCANLAGILTPLVIGFIVAGFGNFFYALIYIGGAALLGVAAYLF 428
Cdd:cd17473 323 AMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
31-194 |
6.80e-11 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 63.75 E-value: 6.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 31 LAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGM 110
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 111 AVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLF---VSVG 187
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFyinLPIG 160
|
....*..
gi 556285271 188 VVGILFA 194
Cdd:cd17503 161 ILALLLA 167
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
15-359 |
1.76e-10 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 62.29 E-value: 1.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 15 AVTARRSRRRIGILALLAIGtMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTY 94
Cdd:PRK11551 5 TSSASSSRLALTIGLCFLVA-LLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRIL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 95 FLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIM 174
Cdd:PRK11551 84 IVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 175 DGFGWRVLFVSVGVVGILFALVWWRCYREphedprlsqqEREHIENGGGLSAPAdqqvafswPLVRQLLSKRQ---IIGA 251
Cdd:PRK11551 164 GDAAWRHIFYVGGVGPLLLVPLLMRWLPE----------SRAFAQAAGAGKQRA--------PVLRALFGEGRataTLLL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 252 SIGQFAGNTVLVFFLTWFPTWLAtERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLlkatgsanlgRKLPIVagLLMA 331
Cdd:PRK11551 226 WISYFFTLIVLYFLLNWLPSLLV-GQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRL----------RPRRVV--LLIY 292
|
330 340
....*....|....*....|....*...
gi 556285271 332 SCIISANWLQSDLAVILVMSFAFFGQGM 359
Cdd:PRK11551 293 AGILASLAALAAAPSFAGMLLAGFAAGL 320
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
59-198 |
6.94e-10 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 60.43 E-value: 6.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 59 DPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLF--HGMAVGLKTLLLCRFGLGVSEAPCFPVNS 136
Cdd:cd17382 47 TPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLipIAARVHYGCVIFVRILQGLVEGVTYPACH 126
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556285271 137 RVVSAWFPQQERAK-ATAVYTvGEYLGLACFAPLLFWIMDGFGWRVLFVSVGVVGILFALVWW 198
Cdd:cd17382 127 GIWRKWAPPLERSRlATTAFC-GSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWM 188
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
31-205 |
9.08e-10 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 60.47 E-value: 9.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 31 LAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGM 110
Cdd:TIGR00711 7 LMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 111 AVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLF---VSVG 187
Cdd:TIGR00711 87 APNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFlinVPIG 166
|
170
....*....|....*...
gi 556285271 188 VVGILFALVWWRCYREPH 205
Cdd:TIGR00711 167 IIVVVVAFFILPRDKPAA 184
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
64-418 |
9.33e-10 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 60.18 E-value: 9.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 64 GILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMA--VGLKTLLLCRFGLGVSEAPCFPVNSRVVSA 141
Cdd:cd17381 68 GWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAadLGAGYLIAVRALEGLGEGVTFPAMHAMWAS 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 142 WFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLFVSVGVVGILFALVWWrcyrephedprlsqqerehieng 221
Cdd:cd17381 148 WAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWI----------------------- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 222 gGLSAPAdqqvafsWPLVrqllskrqiigasIGQFAGNTVLVFFLTWFPTWLATERHMPWLKVGFFSILPFVAAAGGVMF 301
Cdd:cd17381 205 -WLVMPL-------WAIV-------------VAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMIL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 302 GGWISDKLL-KATGSANLGRKLPIVAGLLM-ASCIISANWLQSD--LAVI-LVMSFAFFGQGMVGLGWTLIsDIAPKGLG 376
Cdd:cd17381 264 SGQIADNLReKQNFSTVCVRKIFTLIGMIGpAVFLLAAGFTGCNysLAVAfLTISSTLGGFSASGFNINHL-DIAPSYAG 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 556285271 377 GLTGGLFNFcANLAGILTPLVIGFI-----VAGFGNFFY--ALIYIGGA 418
Cdd:cd17381 343 ILLGITNTF-ATIPGMVGPVIAKSLthnntVEEWQTVFYisAAINVFGA 390
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
64-199 |
5.40e-09 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 54.58 E-value: 5.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 64 GILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWF 143
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 556285271 144 PQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLFVSVGVVGILFALVWWR 199
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAF 136
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
28-361 |
5.66e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 57.59 E-value: 5.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 28 LALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLF 107
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 108 HGMAVGLKTLLLCRF--GLGVSeapCFPVNSRVVSA-WFPQQERAKATAvytvgeYLGLA-CFAPLLF-----WIMDGFG 178
Cdd:cd17320 81 CALASSIEQLLIARFlqGLGAA---AGSVVARAIVRdLYSGAELAKIFS------LLMMIlAIAPALApllggLLLLFFG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 179 WRVLFVSVGVVGILFALVWWRCYREPHEDPRLSQQEREHIENGgglsapadqqvafswplvRQLLSKRQIIGASIGQFAG 258
Cdd:cd17320 152 WRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAY------------------KRVLKNRRFLGYALALGLS 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 259 NTVLVFFLTWFPTWLATERHMPWLKVGFFsilpFVAAAGGVMFGGWISDKLLKATGSANLGRkLPIVAGLLMASCIISAN 338
Cdd:cd17320 214 FAGLFAYLAAAPFIYIEQLGLSPAQFGLL----FALNAIALILGSLLNGRLVRRFGPRRLLR-LGLLLLLAAALVLLLAA 288
|
330 340
....*....|....*....|....*
gi 556285271 339 WLQ--SDLAVILVMSFAFFGQGMVG 361
Cdd:cd17320 289 LLGglSLWPLVAPLFLIFFGFGLIF 313
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
24-202 |
9.35e-09 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 57.03 E-value: 9.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 24 RIGILALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSL 103
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 104 FTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLF 183
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170
....*....|....*....
gi 556285271 184 VSVGVVGILFALvwWRCYR 202
Cdd:cd17488 161 YVPGIIAILMGI--VLCWR 177
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
5-309 |
1.54e-08 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 56.64 E-value: 1.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 5 SPNPTAAAQPAVTARRSRRRIGILALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLF 84
Cdd:PRK11663 2 ADAPLITDKHEIDARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 85 LDRfgNKVTYFLSLTLwsLFTLFHGMAVGLKTLLLCRFGLGVSEAPC----FPVNSRVVSAWFPQQERAKATAVYTVGEY 160
Cdd:PRK11663 82 SDR--SNARYFMGIGL--IATGIINILFGFSSSLWAFALLWVLNAFFqgwgWPVCAKLLTAWYSRTERGGWWAIWNTAHN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 161 LGLACFAPLLFWIMDGFGWRVLFVSVGVVGILFAL-VWWRCYREPHE-------DPRLSQQEREHIENGGGLSApadqqv 232
Cdd:PRK11663 158 VGGALIPLVVGAIALHYGWRYGMMIAGIIAIVVGLfLCWRLRDKPQAmglpsvgEWRHDALELAQQQEGAGLSR------ 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 233 afswplvRQLLSKRQIIGASIGQFAGNTVLVFFL-----TWFPTWLATERHMPWLK----VGFFSILPFVaaagGVMFGG 303
Cdd:PRK11663 232 -------KEILTKYVLLNPYIWLLSFSYVLVYVVraainDWGNLYMSETLGVDLVTansaVSMFELGGFI----GALVAG 300
|
....*.
gi 556285271 304 WISDKL 309
Cdd:PRK11663 301 WGSDKL 306
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
57-425 |
1.22e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 53.33 E-value: 1.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 57 GIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVseapCFPVNS 136
Cdd:cd17477 27 GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGI----GLAGLF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 137 RVVSAWF----PQQERAKATAVYTVGEYLGLACfAPLLFWIMDGFGWRVLFVSVGVVGILFALVWWRcyrePHEDPRLSQ 212
Cdd:cd17477 103 VVSESWLnalaTNENRGRVLGLYSTVLGLGFAL-GPLLLALVGTAGALPFLIAAVLLLLALVPLLLT----RRAAPEIEE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 213 QERehienggglsapadqqvafswplVRQLLSKRQIIGASIGQFAGNTVLVFFLTWFPTWlATERHMPwlkVGFFSILPF 292
Cdd:cd17477 178 AES-----------------------ISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLY-GLRLGLS---VAQAALLLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 293 VAAAGGVMFG---GWISDKLLKatgsanlgRKLPIVAGLLMASCIISANWLQSDLAVILVMSFAF--FGQGMVGLGWTLI 367
Cdd:cd17477 231 AFVLGGLLLQwplGWLADRFDR--------RRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWggAAGPLYTLALALA 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 556285271 368 SDIAPKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGNFFYALIYIGGAALLGVAA 425
Cdd:cd17477 303 GDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
63-428 |
2.27e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 52.71 E-value: 2.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 63 MGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRF----GLGVSEAPcfpVNSRV 138
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFlaglGAGILDTG---ANTFV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 139 VSAWFPQQERA--KATAVYTVGEYLGLACFAPLLFWimdGFGWRVLFVSVGVVGILFALVWWRCYREPHEDprlsqqere 216
Cdd:cd17333 110 GALFEESSATRlnVLHGFFGLGALIGPLIATSLLTS---ELSWSWAYLIIGLIYLLLAILILLTLFPELPS--------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 217 hienggglSAPADQQVAFSWPLVRQLLSKRQIIGASIGQFAGNTVLVFFLTWFPTWLATERHMPWLKVGFFSILPFVAAA 296
Cdd:cd17333 178 --------ARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGIT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 297 GGVMFGGWISDKLLKATgsanlgrKLPIVAGLLMASCIIsaNWLQSDLAVILVmSFAFFGQGMVGLGWTLISDIAP--KG 374
Cdd:cd17333 250 IGRLLGGPISRRIKPHT-------LLVLSGSGALLGLLI--LLLAPTLVVGLV-ATALLGLFMAALFPTILSLGISnlPY 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 556285271 375 LGGLTGGLFNFCANLAGILTPLVIGFIVAgFGNFFYALIYIGGAALLGVAAYLF 428
Cdd:cd17333 320 AKGKGTSVLLAAGSIGGAIIPFIMGFIAE-AVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
28-183 |
4.25e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 51.81 E-value: 4.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 28 LALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLF 107
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556285271 108 HGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGlACFAPLL-FWIMDGFGWRVLF 183
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLG-PALGPIIgGFITQSLGWRWIF 156
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
50-421 |
1.02e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.63 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 50 PKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEA 129
Cdd:cd17478 20 PLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 130 PCFPVNSRVVSAWFPQQeRAKATAVYTVGEYLGLAcFAPLLF-WIMDGFGWRVLFVSVGVVGILFALVWWRCYREPHEDP 208
Cdd:cd17478 100 AFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFA-LGPLIAaALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 209 RLSQQEREhienggglSAPADQQVAFSWPLVRQLLSKRQIIGASIGQFagntvlvffltwFPTWLATERHMPWLKVGFFS 288
Cdd:cd17478 178 KKAAAKSS--------ARSTLKGVWRALLLLLIIVFLRSWVLSSLTTF------------LPFYLVQRGYSLVFAGLLLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 289 ILPFVAAAGGVMfGGWISDKllkatgsanLGRKLPIVAG-LLMASCIISANWLQSDLAVILVMSFAFFGQGMVGLGWTLI 367
Cdd:cd17478 238 LFLFAGAIGTLI-GGPLSDR---------FGRRRVIIASlLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLA 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 556285271 368 SDIAPKGLGGLTGGLFNFCANLAGILTPlVIGFI--VAGFGNFFYALIYIGGAALL 421
Cdd:cd17478 308 QELLPGNVGLASGLMMGLSFGLGGIGAP-VLGALadAFGLESVLLILALLPLLGAL 362
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-162 |
1.17e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 50.36 E-value: 1.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 6 PNPTAAAQPAVTARRSRRRIGILALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFL 85
Cdd:COG2814 188 SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLA 267
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556285271 86 DRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLG 162
Cdd:COG2814 268 DRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
18-199 |
1.35e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 50.31 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 18 ARRSRRRIGILALLAIGTMINYLDRTVLGIAAPKLTGE-LGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFL 96
Cdd:cd06173 200 GLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLI 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 97 SLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDG 176
Cdd:cd06173 280 GALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA 359
|
170 180
....*....|....*....|...
gi 556285271 177 FGWRVLFVSVGVVGILFALVWWR 199
Cdd:cd06173 360 LGLSAVFLLAGALLLLAALLLLL 382
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
33-373 |
2.16e-06 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 49.70 E-value: 2.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 33 IGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALaqipGGLFL----DRFGNKVTYFLSLTLWSLFTLFH 108
Cdd:PRK03893 27 LGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWF----GGLLLgamgDRYGRRLAMVISIVLFSVGTLAC 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 109 GMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLFVsVGV 188
Cdd:PRK03893 103 GFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFF-IGI 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 189 VGILFALvWWRCYREPHEDPRLSQQEREHIEN---------------------GGGLSAPADQQVAFSWPLVRQLLSKRQ 247
Cdd:PRK03893 182 LPIIFAL-WLRKNLPEAEDWKEKHAGKAPVRTmvdilyrgehriinilltlaaAAALWFCFAGNLQNAAIVAVLGLLCAA 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 248 IIGASIGQFAGN----------TVLVFFL-TW-----FPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKllk 311
Cdd:PRK03893 261 IFISFMVQSSGKrwptgvmlmvVVLFAFLySWpiqalLPTYLKTDLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDW--- 337
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556285271 312 atgsanLGRKLPIVAGLLMASCIISANWLQsDLAVILVMSFAFFGQGMVGLGwtlISDIAPK 373
Cdd:PRK03893 338 ------LGTRKAYVCSLLISQLLIIPVFAI-GGANVWVLGLLLFFQQMLGQG---ISGLLPK 389
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
52-204 |
1.31e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 47.16 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 52 LTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPC 131
Cdd:COG0738 237 LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLM 316
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556285271 132 FPVNSRVVSAWFPQQERAKATAVYTVGeYLGLACFAPLLFWIMDGFGWRVLFVSVGVVGILFALVWWRCYREP 204
Cdd:COG0738 317 FPTIFSLALDGLGKRTAAAVSAVLIMG-IVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKR 388
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
47-196 |
1.51e-05 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 46.94 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 47 IAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGV 126
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556285271 127 SEAPCFPVNSRVVSAWFPQQERAKATAVYTvgeylGLACFAPLL-----FWIMDGFGWRVLFVSVGVVGILFALV 196
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLN-----GITCIIPVLapvlgHLIMLKFPWQSLFYTMAAMGILVLLL 173
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
55-429 |
1.82e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 46.50 E-value: 1.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 55 ELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPV 134
Cdd:cd17355 32 EFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 135 NS-RVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWR---VLFVSVGVVGILFALVWWRcyREPHEDPRL 210
Cdd:cd17355 112 VAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRtalLVLALLALLVLVPVLLLLR--RRPADLALR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 211 SQQEREHIENGGGLsapadqqvafswplvRQLLSKRQIIGASIGQFAGNTVLVFFLTWFPTWLATERHMPWLKVGFFSIL 290
Cdd:cd17355 190 AYDDASPASPGSTL---------------KEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALI 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 291 PFVAAAGGVmFGGWISDKLLKAtgsanlgRKLPIVAGLLMASCIISANWLQSDLAVIL-VMSFAFFGQGMVGLGWTLISD 369
Cdd:cd17355 255 GLFNIVGRL-LSGWLGDRYSPR-------RLLAASYALRALGLALLLLLPFPPLALLLfAALFGLGWGATVPLTAALAAR 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 370 IAPKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGNffYALIYIGGAALLGVAAYLFI 429
Cdd:cd17355 327 YFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGS--YTAAWALAVALGLIAALLVL 384
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
28-430 |
2.92e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 2.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 28 LALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLS-----LTLWS 102
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILAdllraLLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 103 LFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVL 182
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 183 FVSVGVVGILFALVWWRCYREPHEDPRlsqqerehienggglsAPADQQVAFSWPLVRQLLSKRQIIGASIGQFAGNTVL 262
Cdd:cd06173 161 FAINALSFLLSALLLLFIRRPPPAAPG----------------ESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 263 VFFLTWFPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLLKatgsanlgRKLPIVAGLLMASCIISANWLQS 342
Cdd:cd06173 225 GALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRR--------GRLLLIGALLLGLALLVLGLSPS 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 343 DLAVILVMSFAFFGQGMVGLGW-TLISDIAPKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGNFfyALIYIGGAALL 421
Cdd:cd06173 297 LWLLLAALFLLGLAGGLFNVPLnTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLS--AVFLLAGALLL 374
|
....*....
gi 556285271 422 GVAAYLFIL 430
Cdd:cd06173 375 LAALLLLLL 383
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
31-368 |
3.73e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 45.63 E-value: 3.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 31 LAIGTMINYLDRTVLGIAAPKLTGELGiDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGM 110
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 111 AVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWR-VLFVSVGVV 189
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRwCFYINLPIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 190 GILFALVwwrcyrephedprlsqqerehienggglsapadqqvafswplvrqllskRQIIGASIGQFAGNTVLVFFLTWF 269
Cdd:cd17502 160 GLALALL-------------------------------------------------RTILLSSIFGFLFGGALFGLIYYL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 270 PTWLATERHMPWLKVGFFSILPfvaaAGGVMFGGWISDKLLKATGSAnlgRKLPIVAGLLMASCIISANWLQSDLAVILV 349
Cdd:cd17502 191 PLYFQLVLGDSATKSGVRLLPL----IIGLVIGSIISGALISKTGRY---KPLIVIGTILMSVGAGLLTTLTLDTSKWLL 263
|
330
....*....|....*....
gi 556285271 350 MSFAFFgqGMVGLGWTLIS 368
Cdd:cd17502 264 IGYLIL--LGLGLGIGFQQ 280
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
22-196 |
3.82e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 45.67 E-value: 3.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 22 RRRIGILALLAIGTMINYldrTVLGIAAPK-LTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTL 100
Cdd:cd17316 176 RRRTLLLILLWFFISFGY---YGLTTFLPTyLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 101 WSLFTLFHGMAVGLK--TLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFG 178
Cdd:cd17316 253 SGILALPLFYLLSGSptLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG 332
|
170
....*....|....*...
gi 556285271 179 WRVLFVSVGVVGILFALV 196
Cdd:cd17316 333 GTGVPALILALLAIVALI 350
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
43-425 |
7.08e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.93 E-value: 7.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 43 TVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVG-LKTLLLCR 121
Cdd:cd17341 16 FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSsYWGLLVLG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 122 FGLGVSEApCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLAC---FAPLLF----WIMDGFGWRVLFVSVGVVGILFA 194
Cdd:cd17341 96 FLLGFAGA-NFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVsqlLAPLIAgaivFDGGFVGWRNAFFVPGILLAIAA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 195 LVWWRCYREPHEDPRLSQQEREHIENGGGLSAPadqqVAFSWplvrqllskrqIIGASIGQFAGntvlvfFLTWFPTWLA 274
Cdd:cd17341 175 VLVLLFGDDLPTGKASALEFLKVQLAVLKNYRT----WILSL-----------LYGVTFGSFVG------FSNVLPTYFK 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 275 TERHMPWLKVGFFSILpfVAAAGGVM--FGGWISDKLlkatgsanLGRKLPIVAGLLMASCIISANWLQSD-----LAVI 347
Cdd:cd17341 234 TRFGLPLVTAGILAAL--FPLAGALArpAGGWLSDRF--------GGRRRLWWLFIVMTIGAALLSLSLPTsgtnlVLFL 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556285271 348 LVMSFAFFGQGMV-GLGWTLISDIAPKGLGGLTGGLFNFcANLAGILTPLVIGFIVAGFGNFFYALIYIGGAALLGVAA 425
Cdd:cd17341 304 ALFVALGLGAGAGnGSVFRMVPFIFRRELGAVTGLVGAI-GGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLL 381
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
30-196 |
8.13e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 44.49 E-value: 8.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 30 LLAIGTMINYLDrTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHG 109
Cdd:cd17504 1 LALAALAVMLVE-TMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 110 MAVGLKTLLLCRFGLGVSeAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVLFVSVGVV 189
Cdd:cd17504 80 FAPNLPVLIAGRALQGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPV 158
|
....*..
gi 556285271 190 GILFALV 196
Cdd:cd17504 159 AVLLAAL 165
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
81-198 |
9.43e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 44.11 E-value: 9.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 81 GGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEY 160
Cdd:cd17317 45 FGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWA 124
|
90 100 110
....*....|....*....|....*....|....*...
gi 556285271 161 LGLACFAPLLFWIMDgfgWRVLFVSVGVVGILFALVWW 198
Cdd:cd17317 125 LGYMLLALLAYLIRD---WRWLQLAISLPGLLFLLLLW 159
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
63-176 |
2.62e-04 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 43.10 E-value: 2.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 63 MGILFSAFAWtyalaqipGGLfLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAW 142
Cdd:cd17439 45 LGMMVGAFLW--------GGL-ADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEF 115
|
90 100 110
....*....|....*....|....*....|....
gi 556285271 143 FPQQERakatavytvGEYLGLACfaplLFWIMDG 176
Cdd:cd17439 116 LAQEKR---------GEHLSWLC----MFWMIGG 136
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
63-176 |
4.40e-04 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 42.66 E-value: 4.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 63 MGILFSAFAWtyalaqipGGLfLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAW 142
Cdd:TIGR01299 213 LGMMVGAFFW--------GGL-ADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEF 283
|
90 100 110
....*....|....*....|....*....|....
gi 556285271 143 FPQQERakatavytvGEYLGLACfaplLFWIMDG 176
Cdd:TIGR01299 284 LAQEKR---------GEHLSWLC----MFWMIGG 304
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
82-204 |
5.10e-04 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 42.22 E-value: 5.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 82 GLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYL 161
Cdd:PRK12307 74 GLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGI 153
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 556285271 162 GLACFAPLLFWIMDGFGWRVLFVsVGVVGILfaLVWWRCYREP 204
Cdd:PRK12307 154 GNIIAAYFMPSFAEAYGWRAAFF-VGLLPVL--LVIYIRARAP 193
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
24-429 |
5.89e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.83 E-value: 5.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 24 RIGILALLAIGTMINYLDRTVLGIAAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSL 103
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 104 FTLFHGMAVGLKTLLLCRFGL-GVSEAPCFPVNSRVVSAWFPQQeRAKATAVYTVGEYLGLACFAPLLFWIMDGFGWRVL 182
Cdd:cd17353 81 GFILSAFAISLPLLFLGYGVLgGIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 183 FVSVGVVGILFALVWWRCYREPhedPRLSQQEREHIENGGGLSAPADQQvafswplVRQLLSKRQIIGASIGQFAGNTVL 262
Cdd:cd17353 160 FLILGIIFLIIIVIGAFLIRDP---PKGWVPPGVDPLANNAENSPRDYT-------PREMLRTPTFWLLWLMFFLNATAG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 263 VFFLTWFPTWLATERHMPWLK-VGFFSILPFVAAAGGVMFgGWISDKllkatgsanLGRKLPIVAGLLMASCIISANWLQ 341
Cdd:cd17353 230 LMLIGQAKPIGQEFAGLDAGIaALAVSILSIFNGGGRPFW-GWLSDK---------IGRKNTLSIAFLIQGVAMFLLPFI 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 342 SDLAVILVMSFAFFGQGMvGLGWTLISDIAPKGLGGLtgglfNFCAN---------LAGILTPLVIGFIVAgFGNFFYAL 412
Cdd:cd17353 300 GSVAVLFVLGVALIGFCY-GGGFALFPALTADFFGTK-----NAGTNygllytakgVGGLIGPIIAAYVLY-TGGYNAAF 372
|
410
....*....|....*..
gi 556285271 413 IYIGGAALLGVAAYLFI 429
Cdd:cd17353 373 IIAAALSLVALALALLL 389
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
32-428 |
8.27e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 41.36 E-value: 8.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 32 AIGTMINYLDRTVLGIAAPKLTGEL---GIDPAlMGIL--FSAFAWTYaLAQIPGGLFL----DRFGNKVTYFLSLTLWS 102
Cdd:cd17369 8 LVGTAIEWYDFFIYGTAAALVFNKLffpAVDPA-AGTLaaFATFGVGF-LARPLGGVVFghfgDRIGRKKTLVLTLLLMG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 103 LFTlfhgMAVGL------------KTLLLCRFGLGVSEAPCFPVNSRVVSAWFPQQERAKATAVYTVGEYLGLAcFAPLL 170
Cdd:cd17369 86 IAT----FLIGLlptyaqigilapILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLL-LATGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 171 FWIMDGF---------GWRVLFVSVGVVgILFALVWwrcyrephedpRLSQQEREHIEnggglSAPADQQVAFSWPLVRQ 241
Cdd:cd17369 161 FLLLSALlsdeaflswGWRIPFLLSAVL-VAVGLYI-----------RLRLEETPVFR-----RAKEAGQVVRAPLVEVL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 242 LLSKRQIIGASIGQFAGNTVLVFFLTWFPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLlkatgsanlGRK 321
Cdd:cd17369 224 RRHWRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRV---------GRR 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 322 LPIVAG-LLMASCIISANWL---QSDLAVILVMSFAFF-GQGMV-GLGWTLISDI-APKGLGGLTGGLFNFCANLAGILT 394
Cdd:cd17369 295 PVYLAGaLLAALFAFPFFWLldtGSTWLIVLAAVVVLGvLHGMMyGPQAAFLAELfPTRVRYTGASLGYQLGAILGGGFA 374
|
410 420 430
....*....|....*....|....*....|....
gi 556285271 395 PLVIGFIVAGFGNFFYALIYIGGAALLGVAAYLF 428
Cdd:cd17369 375 PLIATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
64-198 |
1.79e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 40.38 E-value: 1.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 64 GILFSAFAWTYALaqipgglflDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVSEAPCFPVNSRVVSAWF 143
Cdd:TIGR00898 139 GVLLGSFVFGYLS---------DRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFL 209
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 556285271 144 PQQERAKATAVYTVGEYLGLACFAPLLFWIMDgfgWRVLFVSVGVVGILFALVWW 198
Cdd:TIGR00898 210 PKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD---WRWLQLAVSLPTFLFFLLSW 261
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
82-429 |
2.33e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 40.05 E-value: 2.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 82 GLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTL------------LLCRFGLGVSEAPCF--------PVNSRVVSA 141
Cdd:cd17368 61 GAYADRIGRKPAMTLTLAIMALGTLLIALAPTYATIgiaapllvllarLLQGFAAGGEVGGVTaylveaapPGRRGFYTS 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 142 WFPQQERAKATAVYTVGEYLGLAcfapLLFWIMDGFGWRV-LFVSVGVVGILFALvwwrcyrephedpRLSQQEREhien 220
Cdd:cd17368 141 WQSASQQVAIVAGALVGYLLSLT----LTAEALAEWGWRIpFFIGLLIIPLGLWL-------------RRSLEETE---- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 221 ggglSAPADQQVAFSWPLVRQLLSKRQIIGASIGQFAGNTVLVFFLTWF-PTWLATERHMPWLKVGFFSILPFVAAAGGV 299
Cdd:cd17368 200 ----AFLERKARPTRRELFALLANNRRIILLGMLLVAGSTVTFYFTTVYtPTYAKTVLGLSARDSFLVTLLAGVANFIWA 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 300 MFGGWISDKLlkatgsanlGRK----LPIVAGLLMA----SCIISANWLQSDLAVILVMSFAFFGQGmvGLGWTLISDIA 371
Cdd:cd17368 276 PLGGALSDRI---------GRRpvllVITLAALVTLypvfAWLTAAPSFGRLLLVLLVLSFFFGMYG--GAMVVALVELF 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 556285271 372 PKGL-GGLTGGLFNFCANLAGILTPLVIGFIVAGFGNFFYALIYIGGAALLGVAAYLFI 429
Cdd:cd17368 345 PVRVrSTGFSLVYALAVAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAALLGLLATLML 403
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
48-199 |
3.26e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 39.51 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 48 AAPKLTGELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKVTYFLSLTLWSLFTLFHGMAVGLKTLLLCRFGLGVS 127
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 128 EAPCFPVNSRVVSAWFPQQERAKA----TAVYTVgeylglacfAPLLF-----WIMDGFGWRVLFVSVGVVGILFA-LVW 197
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMmsfvTLVMTI---------APLLApiiggWLLVWFSWHAIFWVLALAAILAAaLVF 163
|
..
gi 556285271 198 WR 199
Cdd:PRK11102 164 FF 165
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
252-437 |
4.20e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.94 E-value: 4.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 252 SIGQFAGNTVLVFFLTWFPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLlkatgsanlGRKLPIVAGLLMA 331
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF---------GRRRVLLIGLLLF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 332 SCIISANWLQSDLAVILVMSF--AFFGQGMVGLGWTLISDIAPKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGnfF 409
Cdd:pfam07690 73 ALGLLLLLFASSLWLLLVLRVlqGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG--W 150
|
170 180
....*....|....*....|....*...
gi 556285271 410 YALIYIGGAALLGVAAYLFILGDVKRIE 437
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPRPPPESK 178
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
21-311 |
5.32e-03 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 38.92 E-value: 5.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 21 SRRRIGILALLAIGTMINYLDRTVLGIAAPKLTgELGIDPALMGILFSAFAWTYALAQIPGGLFLDRFGNKvtYFLS--L 98
Cdd:PRK11273 24 RRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLV-EQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPR--VFLPagL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 99 TLWSLFTLFHG--------MAVGLKTLLLCRFGLGVSEAPCfpvnSRVVSAWFPQQERAKATAVYTVGEYLGLACFAPLL 170
Cdd:PRK11273 101 ILAAAVMLFMGfvpwatssIAVMFVLLFLCGWFQGMGWPPC----GRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 171 FWIMDGFG-WRVLFVSVGVVGILFALVWWRCYREPHEDPRLSQQEREHIENGGGLSAPADQQVAFSWPLVRQLLSKRQII 249
Cdd:PRK11273 177 LLGMAWFNdWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYNEKHEQELTAKQIFMQYVLPNKLLW 256
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556285271 250 GASIGQfagntVLVFF-----LTWFPTWLATERHMPWLKVGFFSILPFVAAAGGVMFGGWISDKLLK 311
Cdd:PRK11273 257 YIAIAN-----VFVYLlrygiLDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFR 318
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
293-429 |
5.54e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.98 E-value: 5.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556285271 293 VAAAGGVMFGGWISDKLlkatgsanlGRKLPIVAGL-LMASCIISANWLQSDLA-VILVMSFAFFGQGMVGLGWTLISDI 370
Cdd:COG2270 285 IVAALGALLFGRLDDRI---------GPKRVILVSLvIWIVVCLAAYFLTTALAfWILGLLIGLVMGGIQALSRSLLARL 355
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 556285271 371 APKGLGGLTGGLFNFCANLAGILTPLVIGFIVAGFGNFFYALIYIGGAALLGVAAYLFI 429
Cdd:COG2270 356 IPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQRLGILSLIVFFVIGLVLLLRV 414
|
|
| |
