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Conserved domains on  [gi|556289714|ref|WP_023290986|]
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MULTISPECIES: phosphoglycerate kinase [Klebsiella]

Protein Classification

phosphoglycerate kinase( domain architecture ID 10011204)

phosphoglycerate kinase catalyzes the conversion of ATP and 3-phospho-D-glycerate to ADP and 3-phospho-D-glyceroyl phosphate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
pgk PRK00073
phosphoglycerate kinase; Provisional
3-383 0e+00

phosphoglycerate kinase; Provisional


:

Pssm-ID: 234613  Cd Length: 389  Bit Score: 637.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714   3 VIKMTDLDLAGKRVFIRADLNVPVKDGKVTSDARIRASLPTIELALKQGAKVMVTSHLGRPTeGEYnEEFSLLPVVNYLK 82
Cdd:PRK00073   1 KKTLDDLDLKGKRVLVRVDFNVPVKDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRPK-GED-PEFSLAPVAKRLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714  83 DKLSSPVRLVKDYLDG------VEVAAGELVVLENVRFNKGEKKDDEALSKKYAALCDVFVMDAFGTAHRAQASTHGIGK 156
Cdd:PRK00073  79 ELLGKEVKFVDDCIGEeareaiAALKDGEVLLLENVRFNKGEEKNDPELAKKLASLGDVFVNDAFGTAHRAHASTVGIAK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 157 FADVACAGPLLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFVAAQGHNVGKSLYEA 236
Cdd:PRK00073 159 FLKPAAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVLENLLEKVDKLIIGGGMANTFLKAQGYNVGKSLVEE 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 237 DLVDEAKRLLST-----CDIPVPTDVRVATEFSEtATATLKSVNDIKDDEQILDLGDVSAQKLADILKNAKTILWNGPVG 311
Cdd:PRK00073 239 DLIDTAKELLEKakekgVKIPLPVDVVVAKEFSD-AEATVVSVDEIPDDWMILDIGPKTIELFAEIIKDAKTIVWNGPMG 317
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556289714 312 VFEFPNFRKGTEIVANAIADSEGFSIAGGGDTLAAIDLFGIADKISYISTGGGAFLEFVEGKVLPAVAMLEE 383
Cdd:PRK00073 318 VFEFENFAKGTKAVAKAIAESTAFSIIGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGKELPGVAALEE 389
 
Name Accession Description Interval E-value
pgk PRK00073
phosphoglycerate kinase; Provisional
3-383 0e+00

phosphoglycerate kinase; Provisional


Pssm-ID: 234613  Cd Length: 389  Bit Score: 637.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714   3 VIKMTDLDLAGKRVFIRADLNVPVKDGKVTSDARIRASLPTIELALKQGAKVMVTSHLGRPTeGEYnEEFSLLPVVNYLK 82
Cdd:PRK00073   1 KKTLDDLDLKGKRVLVRVDFNVPVKDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRPK-GED-PEFSLAPVAKRLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714  83 DKLSSPVRLVKDYLDG------VEVAAGELVVLENVRFNKGEKKDDEALSKKYAALCDVFVMDAFGTAHRAQASTHGIGK 156
Cdd:PRK00073  79 ELLGKEVKFVDDCIGEeareaiAALKDGEVLLLENVRFNKGEEKNDPELAKKLASLGDVFVNDAFGTAHRAHASTVGIAK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 157 FADVACAGPLLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFVAAQGHNVGKSLYEA 236
Cdd:PRK00073 159 FLKPAAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVLENLLEKVDKLIIGGGMANTFLKAQGYNVGKSLVEE 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 237 DLVDEAKRLLST-----CDIPVPTDVRVATEFSEtATATLKSVNDIKDDEQILDLGDVSAQKLADILKNAKTILWNGPVG 311
Cdd:PRK00073 239 DLIDTAKELLEKakekgVKIPLPVDVVVAKEFSD-AEATVVSVDEIPDDWMILDIGPKTIELFAEIIKDAKTIVWNGPMG 317
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556289714 312 VFEFPNFRKGTEIVANAIADSEGFSIAGGGDTLAAIDLFGIADKISYISTGGGAFLEFVEGKVLPAVAMLEE 383
Cdd:PRK00073 318 VFEFENFAKGTKAVAKAIAESTAFSIIGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGKELPGVAALEE 389
Pgk COG0126
3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; 3-phosphoglycerate kinase ...
6-384 0e+00

3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; 3-phosphoglycerate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439896  Cd Length: 389  Bit Score: 539.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714   6 MTDLDLAGKRVFIRADLNVPVKDGKVTSDARIRASLPTIELALKQGAKVMVTSHLGRPtEGEYNEEFSLLPVVNYLKDKL 85
Cdd:COG0126    2 LDDLDLKGKRVLVRVDFNVPLDDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRP-KGKVDPKYSLKPVAERLSELL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714  86 SSPVRLVKDyLDGVEVAA-------GELVVLENVRFNKGEKKDDEALSKKYAALCDVFVMDAFGTAHRAQASTHGIGKFA 158
Cdd:COG0126   81 GKPVKFVDD-CIGEEAEAavaalkpGEVLLLENLRFHPEEEKNDPEFAKKLASLGDVYVNDAFGTAHRAHASTVGIAKLL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 159 DvACAGPLLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFVAAQGHNVGKSLYEADL 238
Cdd:COG0126  160 P-SAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVIENLLEKVDKLLIGGGMANTFLKAQGYDVGKSLVEEDK 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 239 VDEAKRLLST-----CDIPVPTDVRVATEFSETATATLKSVNDIKDDEQILDLGDVSAQKLADILKNAKTILWNGPVGVF 313
Cdd:COG0126  239 IDTAKEILEKakekgVKIVLPVDVVVADEFSADAERKVVPVDEIPDDWMGLDIGPKTIELFAEVIKDAKTVVWNGPMGVF 318
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556289714 314 EFPNFRKGTEIVANAIADSEGFSIAGGGDTLAAIDLFGIADKISYISTGGGAFLEFVEGKVLPAVAMLEER 384
Cdd:COG0126  319 EMEPFAKGTRAVAKAIAESGAFSVVGGGDTAAAVNKLGLADKFSHVSTGGGASLEFLEGKELPGVEALEDK 389
PGK pfam00162
Phosphoglycerate kinase;
13-373 0e+00

Phosphoglycerate kinase;


Pssm-ID: 425495  Cd Length: 370  Bit Score: 535.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714   13 GKRVFIRADLNVPVKD-GKVTSDARIRASLPTIELALKQGAKVMVTSHLGRPtEGEyNEEFSLLPVVNYLKDKLSSPVRL 91
Cdd:pfam00162   1 GKRVLVRVDFNVPLDDdGKITDDTRIRAALPTIKYLLEKGAKVILMSHLGRP-KGK-DDKFSLKPVAERLSELLGKPVKF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714   92 VKDYLDGVEVAA------GELVVLENVRFNKGEKKDDEALSKKYAALCDVFVMDAFGTAHRAQASTHGIGKFADvACAGP 165
Cdd:pfam00162  79 ADDCIGPEAEAAiaalkpGEVLLLENVRFYKEEEKNDPEFAKKLASLADVYVNDAFGTAHRAHASTVGVAKFLP-SAAGF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714  166 LLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFVAAQGHNVGKSLYEADLVDEAKRL 245
Cdd:pfam00162 158 LMEKELEALSKALENPERPFVAILGGAKVSDKIGVIENLLDKVDKLIIGGGMANTFLKAQGYEIGKSLVEEDKIELAKEL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714  246 LST-----CDIPVPTDVRVATEFSetATATLKSVNDIKDDEQILDLGDVSAQKLADILKNAKTILWNGPVGVFEFPNFRK 320
Cdd:pfam00162 238 LEKakakgVKIVLPVDVVVADEFS--AEGKVVDVDEIPDDWMGLDIGPETIELFAEVIKKAKTIVWNGPMGVFEFENFAK 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 556289714  321 GTEIVANAIADSE--GFSIAGGGDTLAAIDLFGIADKISYISTGGGAFLEFVEGK 373
Cdd:pfam00162 316 GTKAVAKAIAEATagAFSIVGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGK 370
Phosphoglycerate_kinase cd00318
Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the ...
6-383 0e+00

Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level phosphorylation events in the glycolytic pathway. Substrate-level phosphorylation is defined as production of ATP by a process, which is catalyzed by water-soluble enzymes in the cytosol; not involving membranes and ion gradients.


Pssm-ID: 238195  Cd Length: 397  Bit Score: 509.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714   6 MTDLDLAGKRVFIRADLNVPVKDGKVTSDARIRASLPTIELALKQGAKVMVTSHLGRPTeGEYNEEFSLLPVVNYLKDKL 85
Cdd:cd00318    1 IDDLDLKGKRVLVRVDFNVPVDDGKITDDTRIRAALPTIKYLLEQGAKVVLLSHLGRPK-GEPNEKYSLAPVAKALSELL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714  86 SSPVRLVKDYLdGVEVAA-------GELVVLENVRFNKGEKK-------DDEALSKKYAALCDVFVMDAFGTAHRAQAST 151
Cdd:cd00318   80 GQPVTFANDCV-GPEAEEavealkpGDVLLLENVRFYPEEEGkrdddkeADEEFAKKLASLGDVYVNDAFGTAHRAHASM 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 152 HGIGKFaDVACAGPLLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFVAAQGHNVGK 231
Cdd:cd00318  159 VGIALL-LPSAAGFLMEKELKYLAKALENPERPFVAILGGAKVSDKIQVIENLLDKVDYLIIGGGMAFTFLKAQGMDIGK 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 232 SLYEADLVDEAKRLLST-----CDIPVPTDVRVATEFSETATATLKSVNDIKDDEQILDLGDVSAQKLADILKNAKTILW 306
Cdd:cd00318  238 SLFEEDGIELAKSLLEKakakgVKIVLPVDVVVADKFKADANTKVVTDDGIPDGWMGLDIGPKTIELFAEVIRKAKTIVW 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 307 NGPVGVFEFPNFRKGTEIVANAIADSE---GFSIAGGGDTLAAIDLFGIADKISYISTGGGAFLEFVEGKVLPAVAMLEE 383
Cdd:cd00318  318 NGPMGVFEFPAFAKGTKAIADAIAAATkagAFSIIGGGDTAAAAEKFGLADKISHVSTGGGASLELLEGKELPGVAALEE 397
 
Name Accession Description Interval E-value
pgk PRK00073
phosphoglycerate kinase; Provisional
3-383 0e+00

phosphoglycerate kinase; Provisional


Pssm-ID: 234613  Cd Length: 389  Bit Score: 637.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714   3 VIKMTDLDLAGKRVFIRADLNVPVKDGKVTSDARIRASLPTIELALKQGAKVMVTSHLGRPTeGEYnEEFSLLPVVNYLK 82
Cdd:PRK00073   1 KKTLDDLDLKGKRVLVRVDFNVPVKDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRPK-GED-PEFSLAPVAKRLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714  83 DKLSSPVRLVKDYLDG------VEVAAGELVVLENVRFNKGEKKDDEALSKKYAALCDVFVMDAFGTAHRAQASTHGIGK 156
Cdd:PRK00073  79 ELLGKEVKFVDDCIGEeareaiAALKDGEVLLLENVRFNKGEEKNDPELAKKLASLGDVFVNDAFGTAHRAHASTVGIAK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 157 FADVACAGPLLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFVAAQGHNVGKSLYEA 236
Cdd:PRK00073 159 FLKPAAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVLENLLEKVDKLIIGGGMANTFLKAQGYNVGKSLVEE 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 237 DLVDEAKRLLST-----CDIPVPTDVRVATEFSEtATATLKSVNDIKDDEQILDLGDVSAQKLADILKNAKTILWNGPVG 311
Cdd:PRK00073 239 DLIDTAKELLEKakekgVKIPLPVDVVVAKEFSD-AEATVVSVDEIPDDWMILDIGPKTIELFAEIIKDAKTIVWNGPMG 317
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556289714 312 VFEFPNFRKGTEIVANAIADSEGFSIAGGGDTLAAIDLFGIADKISYISTGGGAFLEFVEGKVLPAVAMLEE 383
Cdd:PRK00073 318 VFEFENFAKGTKAVAKAIAESTAFSIIGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGKELPGVAALEE 389
Pgk COG0126
3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; 3-phosphoglycerate kinase ...
6-384 0e+00

3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; 3-phosphoglycerate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439896  Cd Length: 389  Bit Score: 539.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714   6 MTDLDLAGKRVFIRADLNVPVKDGKVTSDARIRASLPTIELALKQGAKVMVTSHLGRPtEGEYNEEFSLLPVVNYLKDKL 85
Cdd:COG0126    2 LDDLDLKGKRVLVRVDFNVPLDDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRP-KGKVDPKYSLKPVAERLSELL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714  86 SSPVRLVKDyLDGVEVAA-------GELVVLENVRFNKGEKKDDEALSKKYAALCDVFVMDAFGTAHRAQASTHGIGKFA 158
Cdd:COG0126   81 GKPVKFVDD-CIGEEAEAavaalkpGEVLLLENLRFHPEEEKNDPEFAKKLASLGDVYVNDAFGTAHRAHASTVGIAKLL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 159 DvACAGPLLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFVAAQGHNVGKSLYEADL 238
Cdd:COG0126  160 P-SAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVIENLLEKVDKLLIGGGMANTFLKAQGYDVGKSLVEEDK 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 239 VDEAKRLLST-----CDIPVPTDVRVATEFSETATATLKSVNDIKDDEQILDLGDVSAQKLADILKNAKTILWNGPVGVF 313
Cdd:COG0126  239 IDTAKEILEKakekgVKIVLPVDVVVADEFSADAERKVVPVDEIPDDWMGLDIGPKTIELFAEVIKDAKTVVWNGPMGVF 318
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556289714 314 EFPNFRKGTEIVANAIADSEGFSIAGGGDTLAAIDLFGIADKISYISTGGGAFLEFVEGKVLPAVAMLEER 384
Cdd:COG0126  319 EMEPFAKGTRAVAKAIAESGAFSVVGGGDTAAAVNKLGLADKFSHVSTGGGASLEFLEGKELPGVEALEDK 389
PGK pfam00162
Phosphoglycerate kinase;
13-373 0e+00

Phosphoglycerate kinase;


Pssm-ID: 425495  Cd Length: 370  Bit Score: 535.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714   13 GKRVFIRADLNVPVKD-GKVTSDARIRASLPTIELALKQGAKVMVTSHLGRPtEGEyNEEFSLLPVVNYLKDKLSSPVRL 91
Cdd:pfam00162   1 GKRVLVRVDFNVPLDDdGKITDDTRIRAALPTIKYLLEKGAKVILMSHLGRP-KGK-DDKFSLKPVAERLSELLGKPVKF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714   92 VKDYLDGVEVAA------GELVVLENVRFNKGEKKDDEALSKKYAALCDVFVMDAFGTAHRAQASTHGIGKFADvACAGP 165
Cdd:pfam00162  79 ADDCIGPEAEAAiaalkpGEVLLLENVRFYKEEEKNDPEFAKKLASLADVYVNDAFGTAHRAHASTVGVAKFLP-SAAGF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714  166 LLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFVAAQGHNVGKSLYEADLVDEAKRL 245
Cdd:pfam00162 158 LMEKELEALSKALENPERPFVAILGGAKVSDKIGVIENLLDKVDKLIIGGGMANTFLKAQGYEIGKSLVEEDKIELAKEL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714  246 LST-----CDIPVPTDVRVATEFSetATATLKSVNDIKDDEQILDLGDVSAQKLADILKNAKTILWNGPVGVFEFPNFRK 320
Cdd:pfam00162 238 LEKakakgVKIVLPVDVVVADEFS--AEGKVVDVDEIPDDWMGLDIGPETIELFAEVIKKAKTIVWNGPMGVFEFENFAK 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 556289714  321 GTEIVANAIADSE--GFSIAGGGDTLAAIDLFGIADKISYISTGGGAFLEFVEGK 373
Cdd:pfam00162 316 GTKAVAKAIAEATagAFSIVGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGK 370
Phosphoglycerate_kinase cd00318
Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the ...
6-383 0e+00

Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level phosphorylation events in the glycolytic pathway. Substrate-level phosphorylation is defined as production of ATP by a process, which is catalyzed by water-soluble enzymes in the cytosol; not involving membranes and ion gradients.


Pssm-ID: 238195  Cd Length: 397  Bit Score: 509.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714   6 MTDLDLAGKRVFIRADLNVPVKDGKVTSDARIRASLPTIELALKQGAKVMVTSHLGRPTeGEYNEEFSLLPVVNYLKDKL 85
Cdd:cd00318    1 IDDLDLKGKRVLVRVDFNVPVDDGKITDDTRIRAALPTIKYLLEQGAKVVLLSHLGRPK-GEPNEKYSLAPVAKALSELL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714  86 SSPVRLVKDYLdGVEVAA-------GELVVLENVRFNKGEKK-------DDEALSKKYAALCDVFVMDAFGTAHRAQAST 151
Cdd:cd00318   80 GQPVTFANDCV-GPEAEEavealkpGDVLLLENVRFYPEEEGkrdddkeADEEFAKKLASLGDVYVNDAFGTAHRAHASM 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 152 HGIGKFaDVACAGPLLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFVAAQGHNVGK 231
Cdd:cd00318  159 VGIALL-LPSAAGFLMEKELKYLAKALENPERPFVAILGGAKVSDKIQVIENLLDKVDYLIIGGGMAFTFLKAQGMDIGK 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 232 SLYEADLVDEAKRLLST-----CDIPVPTDVRVATEFSETATATLKSVNDIKDDEQILDLGDVSAQKLADILKNAKTILW 306
Cdd:cd00318  238 SLFEEDGIELAKSLLEKakakgVKIVLPVDVVVADKFKADANTKVVTDDGIPDGWMGLDIGPKTIELFAEVIRKAKTIVW 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 307 NGPVGVFEFPNFRKGTEIVANAIADSE---GFSIAGGGDTLAAIDLFGIADKISYISTGGGAFLEFVEGKVLPAVAMLEE 383
Cdd:cd00318  318 NGPMGVFEFPAFAKGTKAIADAIAAATkagAFSIIGGGDTAAAAEKFGLADKISHVSTGGGASLELLEGKELPGVAALEE 397
PRK13962 PRK13962
bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional
5-381 5.94e-140

bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional


Pssm-ID: 237572 [Multi-domain]  Cd Length: 645  Bit Score: 412.97  E-value: 5.94e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714   5 KMT--DLDLAGKRVFIRADLNVPVK-DGKVTSDARIRASLPTIELALKQGAKVMVTSHLGRPtEGEYNEEFSLLPVVNYL 81
Cdd:PRK13962   3 KKTirDIDVKGKRVIVRVDFNVPLDeNGNITDDTRIRAALPTIKYLLDHGAKVILVSHLGRP-KGEFDPKFSMAPVAKRL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714  82 KDKLSSPVRLVKDYL-DGVEVAA-----GELVVLENVRFNKGEKKDDEALSKKYAALCDVFVMDAFGTAHRAQASTHGIG 155
Cdd:PRK13962  82 SELLGKEVIFAKDVIgDDAKKAVaqlkeGDVLLLENVRFHKEETKNDPEFAKELASLADIYVNDAFGTAHRAHASTAGVA 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 156 KFADVACaGPLLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFVAAQGHNVGKSLYE 235
Cdd:PRK13962 162 EYLPAVA-GFLMEKEIEFLGKALANPQRPFVAILGGAKVSDKIGVIENLLEKVDKLLIGGGMAYTFLKAKGYEVGKSLVE 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 236 ADLVDEAKRLLSTC-----DIPVPTDVRVATEFSETATATLKSVNDIKDDEQILDLGDVSAQKLADILKNAKTILWNGPV 310
Cdd:PRK13962 241 EDKLDLAKELLAKAeekgvKLLLPVDSVVAKEFKNDAEHKVVPSDAIPEDWMGLDIGPETIELFAKKIADAKTIVWNGPM 320
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556289714 311 GVFEFPNFRKGTEIVANAIADSEGFSIAGGGDTLAAIDLFGIADKISYISTGGGAFLEFVEGKVLPAVAML 381
Cdd:PRK13962 321 GVFEFDNFAEGTRAVAEAVAESGAITIIGGGDSAAAVEKLGFADKMSHISTGGGASLEFLEGKVLPGIACL 391
PLN02282 PLN02282
phosphoglycerate kinase
2-383 3.34e-110

phosphoglycerate kinase


Pssm-ID: 165923  Cd Length: 401  Bit Score: 328.47  E-value: 3.34e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714   2 SVIKMTDLDLAGKRVFIRADLNVPVKDG-KVTSDARIRASLPTIELALKQGAKVMVTSHLGRPTEgeYNEEFSLLPVVNY 80
Cdd:PLN02282   6 SVGTLKEADLKGKRVFVRVDLNVPLDDNsNITDDTRIRAAVPTIKYLMGHGARVILCSHLGRPKG--VTPKYSLKPLVPR 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714  81 LKDKLSSPVRLVKDYLdGVEVAA-------GELVVLENVRFNKGEKKDDEALSKKYAALCDVFVMDAFGTAHRAQASTHG 153
Cdd:PLN02282  84 LSELLGVEVVMANDCI-GEEVEKlvaelpeGGVLLLENVRFYKEEEKNDPEFAKKLASLADVYVNDAFGTAHRAHASTEG 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 154 IGKFADVACAGPLLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFVAAQGHNVGKSL 233
Cdd:PLN02282 163 VAKYLKPSVAGFLMQKELDYLVGAVANPKKPFAAIVGGSKVSTKIGVIESLLEKVDILLLGGGMIFTFYKAQGYSVGSSL 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 234 YEADLVDEAKRLLSTC-----DIPVPTDVRVATEFSETATATLKSVNDIKDDEQILDLGDVSAQKLADILKNAKTILWNG 308
Cdd:PLN02282 243 VEEDKLDLATSLIEKAkakgvSLLLPTDVVIADKFAPDANSKVVPASAIPDGWMGLDIGPDSIKTFSEALDTTKTIIWNG 322
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556289714 309 PVGVFEFPNFRKGTEIVANAIADSEG---FSIAGGGDTLAAIDLFGIADKISYISTGGGAFLEFVEGKVLPAVAMLEE 383
Cdd:PLN02282 323 PMGVFEFEKFAAGTEAIAKKLAELSGkgvTTIIGGGDSVAAVEKVGLADKMSHISTGGGASLELLEGKPLPGVLALDD 400
PLN03034 PLN03034
phosphoglycerate kinase; Provisional
2-383 4.35e-108

phosphoglycerate kinase; Provisional


Pssm-ID: 178602 [Multi-domain]  Cd Length: 481  Bit Score: 325.80  E-value: 4.35e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714   2 SVIKMTDLDLAGKRVFIRADLNVPVKDG-KVTSDARIRASLPTIELALKQGAKVMVTSHLGRPTEgeYNEEFSLLPVVNY 80
Cdd:PLN03034  81 SVGDLTSADLKGKKVFVRADLNVPLDDNqNITDDTRIRAAIPTIKYLISNGAKVILSSHLGRPKG--VTPKFSLAPLVPR 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714  81 LKDKLSSPVRLVKDYLdGVEVAA-------GELVVLENVRFNKGEKKDDEALSKKYAALCDVFVMDAFGTAHRAQASTHG 153
Cdd:PLN03034 159 LSELLGIQVVKADDCI-GPEVEKlvaslpeGGVLLLENVRFYKEEEKNEPEFAKKLASLADLYVNDAFGTAHRAHASTEG 237
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 154 IGKFADVACAGPLLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFVAAQGHNVGKSL 233
Cdd:PLN03034 238 VTKFLKPSVAGFLLQKELDYLVGAVSNPKRPFAAIVGGSKVSSKIGVIESLLEKCDILLLGGGMIFTFYKAQGLSVGSSL 317
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 234 YEADLVDEAKRLLSTC-----DIPVPTDVRVATEFSETATATLKSVNDIKDDEQILDLGDVSAQKLADILKNAKTILWNG 308
Cdd:PLN03034 318 VEEDKLELATSLLAKAkakgvSLLLPTDVVIADKFAPDANSKIVPASAIPDGWMGLDIGPDSVKTFNEALDTTQTVIWNG 397
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556289714 309 PVGVFEFPNFRKGTEIVANAIADSEG---FSIAGGGDTLAAIDLFGIADKISYISTGGGAFLEFVEGKVLPAVAMLEE 383
Cdd:PLN03034 398 PMGVFEFEKFAVGTEAVAKKLAELSGkgvTTIIGGGDSVAAVEKVGVADVMSHISTGGGASLELLEGKELPGVVALDE 475
PTZ00005 PTZ00005
phosphoglycerate kinase; Provisional
4-381 1.81e-103

phosphoglycerate kinase; Provisional


Pssm-ID: 173310  Cd Length: 417  Bit Score: 311.62  E-value: 1.81e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714   4 IKMTDLDLAGKRVFIRADLNVPVKDGKVTSDARIRASLPTIELALKQGAK-VMVTSHLGRPtEGEYNEEFSLLPVVNYLK 82
Cdd:PTZ00005   8 IDDVDDQLKGKRVLIRVDFNVPIKEGVIKDATRIKATLPTIKYLLEQGAKsVVLMSHLGRP-DGRRVEKYSLKPVVPKLE 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714  83 DKLSSPVRLVKDYLdGVEVAA-------GELVVLENVRFNKGE------------KKDDEALSK---KYAALCDVFVMDA 140
Cdd:PTZ00005  87 ELLGKKVTFLNDCV-GPEVEEacanaknGSVILLENLRFHIEEegkgvdangnkvKADKEEVKKfrkSLTKLGDIYVNDA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 141 FGTAHRAQASTHGIGkfADVACAGPLLAAELDALGKALKEPARPMVAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANT 220
Cdd:PTZ00005 166 FGTAHRAHSSMVGVD--LPVKVAGFLMKKELDYFSKALENPQRPFLAILGGAKVADKIQLIKNLLDKVDEMIIGGGMAFT 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 221 FVAA-QGHNVGKSLYE---ADLVDE--AKRLLSTCDIPVPTDVRVATEFSetATATLKSVND---IKDDEQILDLGDVSA 291
Cdd:PTZ00005 244 FKKVlDNMPIGKSLFDeegAKIVKEimEKAKEKNVKIHLPVDFVCADKFD--NNANTKVVTDkegIPDGWMGLDAGPKSI 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556289714 292 QKLADILKNAKTILWNGPVGVFEFPNFRKGTEIVANAI--ADSEG-FSIAGGGDTLAAIDLFGIADKISYISTGGGAFLE 368
Cdd:PTZ00005 322 EEFAEAILRAKTIVWNGPQGVFEMPNFAKGSIAMLDAVvkATEKGaITIVGGGDTASLVEKTGAANKVSHVSTGGGASLE 401
                        410
                 ....*....|...
gi 556289714 369 FVEGKVLPAVAML 381
Cdd:PTZ00005 402 LLEGKELPGVVAL 414
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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