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Conserved domains on  [gi|556293081|ref|WP_023291729|]
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MULTISPECIES: LysM-like peptidoglycan-binding domain-containing protein [Klebsiella]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OapA pfam04225
Opacity-associated protein A LysM-like domain; The OapA domain gets its name from the ...
 139-224 5.45e-42

Opacity-associated protein A LysM-like domain; The OapA domain gets its name from the Haemophilus influenzae protein OapA, which is required for the expression of colony opacity, thus opacity- associated protein A. The OapA protein is required for efficient nasopharyngeal mucosal colonization, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation. The OapA domain has been shown to bind to peptidoglycan in the E. coli protein YtfB. A screen to identify factors that affect cell division in E. coli discovered that overproducing a fragment of YtfB, including its OapA domain, caused cells to grow as long filaments. OapA domains are commonly associated with other domains that are involved in breaking peptidoglycan cross-links. The OapA domain is distantly related to pfam01476.


:

Pssm-ID: 427799 [Multi-domain]  Cd Length: 85  Bit Score: 137.10  E-value: 5.45e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556293081  139 QWRTYRIESGKTLAQLFRDHGLPATDVYAMAQVEGAGKPLSTLQSGQTVQIRQNANGVVTGLTIDTGNgQQVLFTRQSNG 218
Cdd:pfam04225   1 NWKTYTVPKGDTLAQLFRDNNLPISDVNAMAKVEGADKPLSNIKSGQLVRIKLNAQGRVDELQIENGA-KSVMFFRQSDG 79


                  ....*.
gi 556293081  219 SFVRAR 224
Cdd:pfam04225  80 SFGRKK 85
OapA COG3061
Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell ...
 24-224 8.32e-40

Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell division, chromosome partitioning];


:

Pssm-ID: 442295 [Multi-domain]  Cd Length: 425  Bit Score: 141.34  E-value: 8.32e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556293081  24 LDPLPPMHRRGIIAGFLLVIIGILLPSDDSQNPASTSreanlnlqsqsqpqaggnqavPLPPITNTPTVSdadqmAPVAP 103
Cdd:COG3061    4 MNPLPRKHRRLLGLLSALLLLALLLPSPDASASRVSQ---------------------PLVPLALTAEAD-----APAAA 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556293081 104 EPIQDEQPdqaqtqqpaasqpyqsssqqsapgiEQQWRTYRIESGKTLAQLFRDHGLPATDVYAMAQVEGAGKPLSTLQS 183
Cdd:COG3061   58 APAAPAAP-------------------------EGEWQEYTVQSGDTLSQIFRRLGLSASDLYALLAAEGDAKPLSRLKP 112

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 556293081 184 GQTVQIRQNANGVVTGLTIDTGNGQQVLFTRQSNGsFVRAR 224
Cdd:COG3061  113 GQELRFQLDADGQLQALRYEVSRLETLLFTRQGDG-FQRKR 152
 
Name Accession Description Interval E-value
OapA pfam04225
Opacity-associated protein A LysM-like domain; The OapA domain gets its name from the ...
 139-224 5.45e-42

Opacity-associated protein A LysM-like domain; The OapA domain gets its name from the Haemophilus influenzae protein OapA, which is required for the expression of colony opacity, thus opacity- associated protein A. The OapA protein is required for efficient nasopharyngeal mucosal colonization, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation. The OapA domain has been shown to bind to peptidoglycan in the E. coli protein YtfB. A screen to identify factors that affect cell division in E. coli discovered that overproducing a fragment of YtfB, including its OapA domain, caused cells to grow as long filaments. OapA domains are commonly associated with other domains that are involved in breaking peptidoglycan cross-links. The OapA domain is distantly related to pfam01476.


Pssm-ID: 427799 [Multi-domain]  Cd Length: 85  Bit Score: 137.10  E-value: 5.45e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556293081  139 QWRTYRIESGKTLAQLFRDHGLPATDVYAMAQVEGAGKPLSTLQSGQTVQIRQNANGVVTGLTIDTGNgQQVLFTRQSNG 218
Cdd:pfam04225   1 NWKTYTVPKGDTLAQLFRDNNLPISDVNAMAKVEGADKPLSNIKSGQLVRIKLNAQGRVDELQIENGA-KSVMFFRQSDG 79


                  ....*.
gi 556293081  219 SFVRAR 224
Cdd:pfam04225  80 SFGRKK 85
OapA COG3061
Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell ...
 24-224 8.32e-40

Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442295 [Multi-domain]  Cd Length: 425  Bit Score: 141.34  E-value: 8.32e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556293081  24 LDPLPPMHRRGIIAGFLLVIIGILLPSDDSQNPASTSreanlnlqsqsqpqaggnqavPLPPITNTPTVSdadqmAPVAP 103
Cdd:COG3061    4 MNPLPRKHRRLLGLLSALLLLALLLPSPDASASRVSQ---------------------PLVPLALTAEAD-----APAAA 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556293081 104 EPIQDEQPdqaqtqqpaasqpyqsssqqsapgiEQQWRTYRIESGKTLAQLFRDHGLPATDVYAMAQVEGAGKPLSTLQS 183
Cdd:COG3061   58 APAAPAAP-------------------------EGEWQEYTVQSGDTLSQIFRRLGLSASDLYALLAAEGDAKPLSRLKP 112

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 556293081 184 GQTVQIRQNANGVVTGLTIDTGNGQQVLFTRQSNGsFVRAR 224
Cdd:COG3061  113 GQELRFQLDADGQLQALRYEVSRLETLLFTRQGDG-FQRKR 152
OapA_N pfam08525
Opacity-associated protein A N-terminal motif; This family includes the Haemophilus influenzae ...
 23-49 2.39e-06

Opacity-associated protein A N-terminal motif; This family includes the Haemophilus influenzae opacity-associated protein. This protein is required for efficient nasopharyngeal mucosal colonization, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation. This motif occurs at the N-terminus of these proteins. It contains a conserved histidine followed by a run of hydrophobic residues.


Pssm-ID: 430054  Cd Length: 27  Bit Score: 42.69  E-value: 2.39e-06
                          10        20
                  ....*....|....*....|....*..
gi 556293081   23 LLDPLPPMHRRGIIAGFLLVIIGILLP 49
Cdd:pfam08525   1 LFKPLPKLHRRLLLALSLVVLILLLWP 27
PRK13914 PRK13914
invasion associated endopeptidase;
80-194 1.90e-05

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 44.79  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556293081  80 AVPLPPITNTPTV---SDADQMAPVAPEPIQDEQPDQAQTQQPAASQPYQsssqqsAPGIEQQWRTYRIESGKTLAQLFR 156
Cdd:PRK13914 142 KVTSTPVAPTQEVkkeTTTQQAAPAAETKTEVKQTTQATTPAPKVAETKE------TPVVDQNATTHAVKSGDTIWALSV 215

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 556293081 157 DHGLPATDVYAMAQVEGagkplSTLQSGQTVQIRQNAN 194
Cdd:PRK13914 216 KYGVSVQDIMSWNNLSS-----SSIYVGQKLAIKQTAN 248
 
Name Accession Description Interval E-value
OapA pfam04225
Opacity-associated protein A LysM-like domain; The OapA domain gets its name from the ...
 139-224 5.45e-42

Opacity-associated protein A LysM-like domain; The OapA domain gets its name from the Haemophilus influenzae protein OapA, which is required for the expression of colony opacity, thus opacity- associated protein A. The OapA protein is required for efficient nasopharyngeal mucosal colonization, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation. The OapA domain has been shown to bind to peptidoglycan in the E. coli protein YtfB. A screen to identify factors that affect cell division in E. coli discovered that overproducing a fragment of YtfB, including its OapA domain, caused cells to grow as long filaments. OapA domains are commonly associated with other domains that are involved in breaking peptidoglycan cross-links. The OapA domain is distantly related to pfam01476.


Pssm-ID: 427799 [Multi-domain]  Cd Length: 85  Bit Score: 137.10  E-value: 5.45e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556293081  139 QWRTYRIESGKTLAQLFRDHGLPATDVYAMAQVEGAGKPLSTLQSGQTVQIRQNANGVVTGLTIDTGNgQQVLFTRQSNG 218
Cdd:pfam04225   1 NWKTYTVPKGDTLAQLFRDNNLPISDVNAMAKVEGADKPLSNIKSGQLVRIKLNAQGRVDELQIENGA-KSVMFFRQSDG 79


                  ....*.
gi 556293081  219 SFVRAR 224
Cdd:pfam04225  80 SFGRKK 85
OapA COG3061
Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell ...
 24-224 8.32e-40

Cell division protein YtfB/OapA (opacity-associated protein A) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442295 [Multi-domain]  Cd Length: 425  Bit Score: 141.34  E-value: 8.32e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556293081  24 LDPLPPMHRRGIIAGFLLVIIGILLPSDDSQNPASTSreanlnlqsqsqpqaggnqavPLPPITNTPTVSdadqmAPVAP 103
Cdd:COG3061    4 MNPLPRKHRRLLGLLSALLLLALLLPSPDASASRVSQ---------------------PLVPLALTAEAD-----APAAA 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556293081 104 EPIQDEQPdqaqtqqpaasqpyqsssqqsapgiEQQWRTYRIESGKTLAQLFRDHGLPATDVYAMAQVEGAGKPLSTLQS 183
Cdd:COG3061   58 APAAPAAP-------------------------EGEWQEYTVQSGDTLSQIFRRLGLSASDLYALLAAEGDAKPLSRLKP 112

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 556293081 184 GQTVQIRQNANGVVTGLTIDTGNGQQVLFTRQSNGsFVRAR 224
Cdd:COG3061  113 GQELRFQLDADGQLQALRYEVSRLETLLFTRQGDG-FQRKR 152
OapA_N pfam08525
Opacity-associated protein A N-terminal motif; This family includes the Haemophilus influenzae ...
 23-49 2.39e-06

Opacity-associated protein A N-terminal motif; This family includes the Haemophilus influenzae opacity-associated protein. This protein is required for efficient nasopharyngeal mucosal colonization, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation. This motif occurs at the N-terminus of these proteins. It contains a conserved histidine followed by a run of hydrophobic residues.


Pssm-ID: 430054  Cd Length: 27  Bit Score: 42.69  E-value: 2.39e-06
                          10        20
                  ....*....|....*....|....*..
gi 556293081   23 LLDPLPPMHRRGIIAGFLLVIIGILLP 49
Cdd:pfam08525   1 LFKPLPKLHRRLLLALSLVVLILLLWP 27
PRK13914 PRK13914
invasion associated endopeptidase;
80-194 1.90e-05

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 44.79  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556293081  80 AVPLPPITNTPTV---SDADQMAPVAPEPIQDEQPDQAQTQQPAASQPYQsssqqsAPGIEQQWRTYRIESGKTLAQLFR 156
Cdd:PRK13914 142 KVTSTPVAPTQEVkkeTTTQQAAPAAETKTEVKQTTQATTPAPKVAETKE------TPVVDQNATTHAVKSGDTIWALSV 215

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 556293081 157 DHGLPATDVYAMAQVEGagkplSTLQSGQTVQIRQNAN 194
Cdd:PRK13914 216 KYGVSVQDIMSWNNLSS-----SSIYVGQKLAIKQTAN 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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