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Conserved domains on  [gi|556349276|ref|WP_023298695|]
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MULTISPECIES: transcriptional regulator ExuR [Enterobacter]

Protein Classification

transcriptional regulator ExuR( domain architecture ID 11485381)

transcriptional regulator ExuR is a repressor for the exu regulon that encode genes involved in hexuronate utilization

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11523 PRK11523
transcriptional regulator ExuR;
1-253 0e+00

transcriptional regulator ExuR;


:

Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 511.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276   1 MEITESRRLYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHVISSQAKHS 80
Cdd:PRK11523   1 MEITEPRRLYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276  81 PTPDESLEFASYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMEIQDHARKEKCFRDSEWDLQFHVQVALATQNTALA 160
Cdd:PRK11523  81 QAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMAIQEQARGEDCFRDSEWDLQFHVQVALATQNSALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276 161 AIVEKMWTQRVHNPYWKKLHDHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKQMLFNETSDDFEFNADRY 240
Cdd:PRK11523 161 AIVEKMWTQRSHNPYWKKLHEHIDDRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKQMLFNETSDDFEFNADRY 240

                        250
                 ....*....|...
gi 556349276 241 LFADNPVVHLDTA 253
Cdd:PRK11523 241 LFAENPVVHLDTA 253
 
Name Accession Description Interval E-value
PRK11523 PRK11523
transcriptional regulator ExuR;
1-253 0e+00

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 511.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276   1 MEITESRRLYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHVISSQAKHS 80
Cdd:PRK11523   1 MEITEPRRLYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276  81 PTPDESLEFASYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMEIQDHARKEKCFRDSEWDLQFHVQVALATQNTALA 160
Cdd:PRK11523  81 QAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMAIQEQARGEDCFRDSEWDLQFHVQVALATQNSALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276 161 AIVEKMWTQRVHNPYWKKLHDHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKQMLFNETSDDFEFNADRY 240
Cdd:PRK11523 161 AIVEKMWTQRSHNPYWKKLHEHIDDRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKQMLFNETSDDFEFNADRY 240

                        250
                 ....*....|...
gi 556349276 241 LFADNPVVHLDTA 253
Cdd:PRK11523 241 LFAENPVVHLDTA 253
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
4-232 2.24e-56

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 180.13  E-value: 2.24e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276   4 TESRRLYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHVISSQAKHSPTP 83
Cdd:COG2186    3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276  84 -DESLEFASYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMEIqdHARKEKCFRDSE----WDLQFHVQVALATQNTA 158
Cdd:COG2186   83 lALLLALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAA--LAEMEAAADDGEafaeADLAFHRAIAEASGNPL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556349276 159 LAAIVEKMWtQRVHNPYWKKLHDHidsRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKQMLFNETSDD 232
Cdd:COG2186  161 LALLLESLR-ELLRRSVRLTLRSP---EARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAER 230
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 9-72 4.25e-24

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 91.52  E-value: 4.25e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556349276    9 LYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 9-69 2.27e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 89.81  E-value: 2.27e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556349276   9 LYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSG 69
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRG 62
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
13-72 2.92e-21

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 84.16  E-value: 2.92e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276    13 LAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
 
Name Accession Description Interval E-value
PRK11523 PRK11523
transcriptional regulator ExuR;
1-253 0e+00

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 511.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276   1 MEITESRRLYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHVISSQAKHS 80
Cdd:PRK11523   1 MEITEPRRLYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276  81 PTPDESLEFASYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMEIQDHARKEKCFRDSEWDLQFHVQVALATQNTALA 160
Cdd:PRK11523  81 QAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMAIQEQARGEDCFRDSEWDLQFHVQVALATQNSALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276 161 AIVEKMWTQRVHNPYWKKLHDHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKQMLFNETSDDFEFNADRY 240
Cdd:PRK11523 161 AIVEKMWTQRSHNPYWKKLHEHIDDRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKQMLFNETSDDFEFNADRY 240

                        250
                 ....*....|...
gi 556349276 241 LFADNPVVHLDTA 253
Cdd:PRK11523 241 LFAENPVVHLDTA 253
PRK10225 PRK10225
Uxu operon transcriptional regulator;
1-251 2.79e-78

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 236.84  E-value: 2.79e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276   1 MEITESRRLYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHVISSQAKHS 80
Cdd:PRK10225   2 KSATSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276  81 PTPDESLEFASYGPFELLQARQLIESNIAEFAATQVTKQDIMKL---MEIQDHARKEKCFRDSE-WDLQFHVQVALATQN 156
Cdd:PRK10225  82 TDSPDANVCNDAGPFELLQARQLLESNIAEFAALQATREDIVKMrqaLQLEERELASSAPGSSEsGDMQFHLAIAEATHN 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276 157 TALAAIVEKMWTQRVHNPYWKKLHDHI-DSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKQMLFNETS-DDFE 234
Cdd:PRK10225 162 SMLVELFRQSWQWRENNPMWIQLHSHLdDSLYRKEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLEFSNvDDIY 241

                        250
                 ....*....|....*..
gi 556349276 235 FnaDRYLFADNPVVHLD 251
Cdd:PRK10225 242 F--DGYLFDSWPLDKVD 256
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
4-232 2.24e-56

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 180.13  E-value: 2.24e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276   4 TESRRLYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHVISSQAKHSPTP 83
Cdd:COG2186    3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276  84 -DESLEFASYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMEIqdHARKEKCFRDSE----WDLQFHVQVALATQNTA 158
Cdd:COG2186   83 lALLLALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAA--LAEMEAAADDGEafaeADLAFHRAIAEASGNPL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556349276 159 LAAIVEKMWtQRVHNPYWKKLHDHidsRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKQMLFNETSDD 232
Cdd:COG2186  161 LALLLESLR-ELLRRSVRLTLRSP---EARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAER 230
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
5-225 2.07e-32

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 118.10  E-value: 2.07e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276   5 ESRRLYQQLAAELKDRIEQGVYLVGDKLPaERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHVIssqakhSPTPD 84
Cdd:COG1802    8 RRESLAEQVYEALREAILSGELPPGERLS-EAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVA------PLSPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276  85 ESLefasygpfELLQARQLIESNIAEFAATQVTKQDIMKLMEIQDHARKEKCFRD----SEWDLQFHVQVALATQNTALA 160
Cdd:COG1802   81 EIR--------ELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDvaayLELDREFHRALVEAAGNPRLA 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556349276 161 AIVEKMW--TQRVHNPYWKKLHDHIDSrtvdnwCDDHDQILKALIRKDPHAAKLAMWQHLENTKQML 225
Cdd:COG1802  153 ELLRRLRarLRRYRRLSLRSPGRLEES------LAEHRAILDALEAGDAEAAAAALRAHLERARERL 213
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 9-72 4.25e-24

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 91.52  E-value: 4.25e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556349276    9 LYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 9-69 2.27e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 89.81  E-value: 2.27e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556349276   9 LYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSG 69
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRG 62
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 7-219 4.97e-22

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 91.37  E-value: 4.97e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276   7 RRLYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHVissQAKHSPTPDES 86
Cdd:PRK10421   1 RRLSDEVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI---RWRHETWSEQN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276  87 --------LEFASYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMEIQDHARKEKCFRDSEWDLQFHVQVALATQNTA 158
Cdd:PRK10421  78 ivqplktlMADDPDYSFDILEARHAIEASTAWHAAMRATPGDKEKIQLCFEATLSEDPDLASQADVRFHLAIAEASHNVV 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556349276 159 LAAIVEKMWTQRVHNPYWKKLHDHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLE 219
Cdd:PRK10421 158 LLQTMRGFFDVLQSSVKQSRQRMYLVPPVFSQLTEQHQAVMDAILAGDAEGARKAMMAHLS 218
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
13-72 2.92e-21

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 84.16  E-value: 2.92e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276    13 LAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 7-219 1.57e-19

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 84.69  E-value: 1.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276   7 RRLYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKG-----------SGIHVISS 75
Cdd:PRK03837  12 KKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGerarvsrpsadTIIGQLSG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276  76 QAKH--SPTPDeSLEfasygpfELLQARQLIESNIAEFAATQVTKQDIMKL---MEIQDHAR-KEKCFRDSewDLQFHVQ 149
Cdd:PRK03837  92 MAKDflSQSPD-GLA-------HLKQARLFFESSLARYAAEHATDEQIALLrkaLERNSQSLgDNAAFIRS--DMEFHRV 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556349276 150 VALATQNTALAAIVEKM--W--TQRVHNPYWKKLhdhiDSRTVdnwcDDHDQILKALIRKDPHAAKLAMWQHLE 219
Cdd:PRK03837 162 IAEIPGNPIFMAIHEALldWliEARPEVVILHGH----ENVTL----QEHIAIVDAIRAHDPDEADRALQSHLN 227
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
9-87 1.60e-19

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 84.53  E-value: 1.60e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556349276   9 LYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHVISSQAKHSPTPDESL 87
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSF 84
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 96-220 8.55e-18

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 77.01  E-value: 8.55e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276    96 ELLQARQLIESNIAEFAATQVTKQDIMKLMEIQDHARKEKCFRDS-----EWDLQFHVQVALATQNTALAAIVEKMWTQR 170
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGDDleefaELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 556349276   171 VhnpywkkLHDHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLEN 220
Cdd:smart00895  81 R-------RLRRLSLEAARRALDEHRAILDAIRARDAEAARAAMREHLEA 123
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-102 9.99e-18

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 81.80  E-value: 9.99e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276   1 MEITESRRLYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHVISSQAKHS 80
Cdd:COG1167    5 LDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAPA 84

                         90       100
                 ....*....|....*....|..
gi 556349276  81 PTPDESLEFASYGPFELLQARQ 102
Cdd:COG1167   85 PAPRAAAAVAAPALRRLLEAAP 106
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 96-216 1.05e-13

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 65.85  E-value: 1.05e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276   96 ELLQARQLIESNIAEFAATQVTKQDIMKLMEIQDHARKEKCFRDS----EWDLQFHVQVALATQNTALAAIVEKMWT--Q 169
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLeafaEADREFHLALAEAAGNPVLARMLESLWDrlR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 556349276  170 RVHNPYWKKLHDHidsrtvDNWCDDHDQILKALIRKDPHAAKLAMWQ 216
Cdd:pfam07729  81 RLRRLLLSSPGRL------RASLEEHRAILDAIRARDPEAARAAMRR 121
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
15-232 7.65e-13

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 66.20  E-value: 7.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276  15 AELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHViSSQAKHSPTpDESLEFASYGP 94
Cdd:PRK09464  17 QQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFV-QSSLWQSFS-DPLVELLSDHP 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276  95 ---FELLQARQLIESNIAEFAATQVTKQDIMKLMEIQDHARKEKCFRD----SEWDLQFHVQVALATQNTALAAIVEKMw 167
Cdd:PRK09464  95 esqFDLLETRHALEGIAAYYAALRGTDEDFERIRECHHAIELAQQSGDldaeANAVMQYQIAVTEAAHNVVLLHLLRCM- 173

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556349276 168 tqrvhNPYwkkLHDHI--------DSRTVDNWCDDH-DQILKALIRKDPHAAKLAMWQHLENTKQMLFNETSDD 232
Cdd:PRK09464 174 -----EPM---LEQNVrqnfellyRRREMLPKVSSHrARIFEAIVAGKPEKAREASHRHLAFIEEILLDLSREE 239
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 5-225 4.64e-12

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 64.02  E-value: 4.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276   5 ESRRLYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHVISSQAKHSPTPD 84
Cdd:PRK09990   4 ERRPIADVVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQDASPL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276  85 ESLeFASYgP---FELLQARQLIESNIAEFAATQVTKQDIM-------KLMEIQDHARKEKCFRDSEWDLQFHVQVALAT 154
Cdd:PRK09990  84 MHL-FSSQ-PrtlYDLLEVRALLEGESARLAALRGTQADFVlitrryeEMLAAHENNKEIDPIEHARLDHAFHLAICEAS 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556349276 155 QNT----ALAAIVEKMWTQ---RVHNPYWKKLHD-HIDsrtvdnwcDDHDQILKALIRKDPHAAKLAMWQHLENTKQML 225
Cdd:PRK09990 162 HNPvlvhTLQSLTDLMLSSvfaSVNNLYHRPQQKkQID--------RQHARLYNAVLQRLPEQAQRAARDHIRTVRDNL 232
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
1-124 9.64e-11

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 57.50  E-value: 9.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276   1 MEITESRRLYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSR-TVVReAIIMLEVEGYVEVRKGSGIhVISSQAKh 79
Cdd:COG1725    3 IDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPnTVAK-AYRELEDEGLIETRRGKGT-FVAEDAR- 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 556349276  80 SPTPDESLEFasygpfellqARQLIESNIAEFAATQVTKQDIMKL 124
Cdd:COG1725   80 ELLEERREEF----------LEEALRELVAEARRLGLSLEELLEL 114
PRK11402 PRK11402
transcriptional regulator PhoB;
6-78 3.30e-09

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 55.61  E-value: 3.30e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556349276   6 SRRLYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHVISSQAK 78
Cdd:PRK11402   7 HQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVE 79
PRK09764 PRK09764
GntR family transcriptional regulator;
9-72 1.06e-07

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 51.37  E-value: 1.06e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556349276   9 LYQQLAAELKDRIEQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
Cdd:PRK09764   6 LYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYV 69
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 4-73 2.28e-06

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 47.46  E-value: 2.28e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556349276   4 TESRRLYQQLAAELKDRIeQGVYLVGDKLPAERFIADEKSVSRTVVREAIIMLEVEGYVEVRKGSGIHVI 73
Cdd:PRK10079   8 TSYPTRYQEIAAKLEQEL-RQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVL 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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