|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
15-426 |
8.00e-153 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 440.04 E-value: 8.00e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 15 KAAVSGWLGTALEFMDFQLYSLGAALVFHEIFFPEQSAAMALILAMGTYGAGYIARIVGAFIFGRMGDRIGRKKVLFITI 94
Cdd:cd17369 2 RVALASLVGTAIEWYDFFIYGTAAALVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 95 TMMGICTTLIGVLPTYAQIGIFAPVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIW 174
Cdd:cd17369 82 LLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 175 AVMFFALDREELIAWGWRVPFLASVVVMIFAIWLRMNLKESPVFEKVNDAETiapVAAQDTSLGAMFKSKSFWLATGLRF 254
Cdd:cd17369 162 LLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQ---VVRAPLVEVLRRHWRALLLAIGLRL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 255 GQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRLPYILLNISAIILAYPMLSIIVDK 334
Cdd:cd17369 239 AENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 335 SYAPgvIMLSIIVIHNFAVLGLFALENITMAEMFGSRNRFTRMAISKEAGGLVAVGFGPVLAGIFCNMTGSWWPIVVMLV 414
Cdd:cd17369 319 STWL--IVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGSWWPVALYLA 396
|
410
....*....|..
gi 556356000 415 AYSLIGLVSALL 426
Cdd:cd17369 397 ALAVISLVAALF 408
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
23-421 |
4.32e-141 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 409.74 E-value: 4.32e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 23 GTALEFMDFQLYSLGAALVFHEIFFPEQSAAMALILAMGTYGAGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTT 102
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 103 LIGVLPTYAQIGIFAPVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMFFALD 182
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 183 REELIAWGWRVPFLASVVVMIFAIWLRMNLKESPVFEKVNDAETIAPVaaqdtSLGAMF--KSKSFWLATGLRFGQAGNS 260
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKKRG-----PIAETLtkHRKPFLLGLGLVIATTTTF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 261 GLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRLPYILLNISAIILAYPMLSIIVDKSyaPGV 340
Cdd:TIGR00883 236 YLITTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSG--SFT 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 341 IMLSIIVIHNFAVLGLFALENITMAEMFGSRNRFTRMAISKEAGGLVAVGFGPVLAGIFCNMTGSWWPIVVMLVAYSLIG 420
Cdd:TIGR00883 314 LFFFLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDWYAIGYYLAALALIG 393
|
.
gi 556356000 421 L 421
Cdd:TIGR00883 394 L 394
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
15-427 |
9.25e-72 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 233.47 E-value: 9.25e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 15 KAAVSGWLGTALEFMDFQLYSLGAALVFHEIFFPEQSAAMALILAMGTYGAGYIARIVGAFIFGRMGDRIGRKKVLFITI 94
Cdd:PRK09952 22 RAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLMLTV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 95 TMMGICTTLIGVLPTYAQIGIFAPVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIW 174
Cdd:PRK09952 102 WMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLSTGLV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 175 AVMFFALDREELIAWGWRVPFLASVVVMIFAIWLRMNLKESPVFEKVNDAETIAPVAAqdTSLGAMFKS-KSFWLATGLR 253
Cdd:PRK09952 182 SLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAKKRI--PVIEALLRHpGAFLKIIALR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 254 FGQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRLPYILLNISAIILAYPMLSIIVD 333
Cdd:PRK09952 260 LCELLTMYIVTAFALNYSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFPFFMALEA 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 334 KSYApGVIMLSIIVIhNFAVLGLFALENITMAEMFGSRNRFTRMAISKEAGGLVAVGFGPVLA-GIFCNMTGSWWPIVVM 412
Cdd:PRK09952 340 QSIF-WIVFFSIMLA-NIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAaALVTYFGGSWHSVAIY 417
|
410
....*....|....*
gi 556356000 413 LVAYSLIGLVSALLM 427
Cdd:PRK09952 418 LLAGCLISAMTALLM 432
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
18-431 |
3.47e-56 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 191.35 E-value: 3.47e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 18 VSGWLGTALEFMDFQLYSLgAALVFHEIFFPEQSAAMALILAMGTYGAGYIARIVGAFIFGRMGDRIGRKKVLFITITMM 97
Cdd:cd17367 2 LGGSVGNLVEWYDWYVYAA-FALYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 98 GICTTLIGVLPTYAQIGIFAPVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVM 177
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 178 FFALDREELIAWGWRVPFLASVVVMIFAIWLRMNLKESPVFEKVNDAEtiapvAAQDTSLGAMFKS-KSFWLATGLRFGQ 256
Cdd:cd17367 161 QHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESN-----EASAGTLRELRRHpRELLLVVGLTAGG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 257 AGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRLPYILLNISAIILAYPMLSIIvdkSY 336
Cdd:cd17367 236 TLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSAL---DH 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 337 APGVIMLSIIVIHNFAVLGLF-ALENITMAEMFGSRNRFTRMAISKEAGGLVAVGFGPVLAGIFCNMTGSWW-PIVVMLV 414
Cdd:cd17367 313 TDSPYTAFALVLVGLVFLSGYtSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKSIGHEWVfFWYVAGL 392
|
410
....*....|....*..
gi 556356000 415 AysLIGLVSALLMPEVR 431
Cdd:cd17367 393 I--AISLVVYLRMPETR 407
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
14-429 |
7.12e-56 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 189.88 E-value: 7.12e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 14 VKAAVsgwLGTALEFMDFQLYSLGAALVfHEIFFPEQSAAMALILAMGTYGAGYIARIVGAFIFGRMGDRIGRKKVLFIT 93
Cdd:cd17366 1 VKAAA---LGNAMEWFDFGVYGYLAVTI-GKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAIT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 94 ITMMGICTTLIGVLPTYAQIGIFAPVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAI 173
Cdd:cd17366 77 IILMAASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 174 WAVMFFALDREELIAWGWRVPFLASVVVMIFAIWLRMNLkespvfekvndAETIAPVAAQDTSLGAMFksksfwlatglr 253
Cdd:cd17366 157 VTLLTLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLRRPL-----------LICIGLVLVFNVTNYMLL------------ 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 254 fgqagnsgliqTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRLPYILLNISAIILAYPMLSIIVD 333
Cdd:cd17366 214 -----------SYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNS 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 334 KSYAPGVIMLSIIVIhnfaVLGLF-ALENITMAEMFGSRNRFTRMAISKEAGGLVAVGFGPVLAGIFCNMTGSWWPIVVM 412
Cdd:cd17366 283 GSIAAIFIGLLVLGL----LLSCYtATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGNPLMPAYY 358
|
410
....*....|....*..
gi 556356000 413 LVAYSLIGLVSALLMPE 429
Cdd:cd17366 359 LMVAAVVGLVAVLFLTE 375
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
11-442 |
2.86e-53 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 186.07 E-value: 2.86e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 11 SDLVKAAVSGWLGTALEFMDFQLYSLgAALVFHEIFFPEQSAAMALILAMGTYGAGYIARIVGAFIFGRMGDRIGRKKVL 90
Cdd:PRK10642 12 GKLRKAITAASLGNAMEWFDFGVYGF-VAYALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 91 FITITMMGICTTLIGVLPTYAQIGIFAPVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSA 170
Cdd:PRK10642 91 AITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 171 TAIWAVMFFALDREELIAWGWRVPFLASVVVMIFAIWLRMNLKESPVF----EKVNDAETIAPVAAQDTSLGAMFKS--K 244
Cdd:PRK10642 171 AGVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFqqhvDKLEQGDREGLQDGPKVSFKEIATKhwR 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 245 SFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAipTDALMISSI-LGFLSI-PLLGWLSDKMGRRLPYILLNISAII 322
Cdd:PRK10642 251 SLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSED--HGVLIIIAImIGMLFVqPVMGLLSDRFGRRPFVILGSVALFV 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 323 LAYPMLSIIvdKSYAPGVI---MLSIIVIHNFAVlGLFAlenITMAEMFGSRNRFTRMAISKEAGGLVAvGFGPVLAGIF 399
Cdd:PRK10642 329 LAIPAFILI--NSNVIGLIfagLLMLAVILNCFT-GVMA---STLPAMFPTHIRYSALAAAFNISVLVA-GLTPTLAAWL 401
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 556356000 400 CNMTGSWWPIVVMLVAYSLIGLVSALLMPEVRDRDLSEAEDAA 442
Cdd:PRK10642 402 VESTQNLMMPAYYLMVVAVIGLITGVTMKETANRPLKGATPAA 444
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
22-429 |
4.27e-50 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 175.25 E-value: 4.27e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 22 LGTALEFMDFQLYSLGAALVfHEIFFPEQSAAMALILAMGTYGAGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGICT 101
Cdd:cd17368 6 SGNALEFFDFGVYGFFAVYI-GRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMALGT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 102 TLIGVLPTYAQIGIFAPVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMFFAL 181
Cdd:cd17368 85 LLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSLTL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 182 DREELIAWGWRVPFLASVVVMIFAIWLRMNLKESPVFEKvndaetiAPVAAQDTSLGAMFksKSFWLATGLRFGQAGNSG 261
Cdd:cd17368 165 TAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLE-------RKARPTRRELFALL--ANNRRIILLGMLLVAGST 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 262 LIQTFLAGYLVQTLLFDKAIPTD----ALMISSILGFLSIPLLGWLSDKMGRRLPYILLNISAIILAYPMLSIIVdKSYA 337
Cdd:cd17368 236 VTFYFTTVYTPTYAKTVLGLSARdsflVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLT-AAPS 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 338 PGVIMLSIIVIHNFAVLGLFALEnITMAEMFGSRNRFTRMAISKEAGGLVAVGFGPVLAGIFCNMTGS-WWPIVVMLVAy 416
Cdd:cd17368 315 FGRLLLVLLVLSFFFGMYGGAMV-VALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGSpLAPAWYLMGA- 392
|
410
....*....|...
gi 556356000 417 SLIGLVSALLMPE 429
Cdd:cd17368 393 ALLGLLATLMLRE 405
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
3-368 |
2.63e-45 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 163.06 E-value: 2.63e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 3 QAQPQRSTSDLVKAAVSGWLGTALEFMDFQLYSLgAALVFHEIFFPEQSAAMALILAMGTYGAGYIARIVGAFIFGRMGD 82
Cdd:PRK10406 10 SKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSF-CSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIAD 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 83 RIGRKKVLFITITMMGICTTLIGVLPTYAQIGIFAPVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMG 162
Cdd:PRK10406 89 KHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVT 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 163 TNCGTLSATAIWAVMFFALDREELIAWGWRVPFLASVVVMIFAIWLRMNLKESpvfekvNDAETIAPVAAqdTSLGAMFK 242
Cdd:PRK10406 169 LIGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDET------SQQETRALKEA--GSLKGLWR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 243 S-KSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDkAIPTDALMISSILGFLSI-PLLGWLSDKMGRRLPYILLNISA 320
Cdd:PRK10406 241 NrRAFIMVLGFTAAGSLCFYTFTTYMQKYLVNTAGMH-ANVASGIMTAALFVFMLIqPLIGALSDKIGRRTSMLCFGSLA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 556356000 321 IILAYPMLSII--VDKSYAP-GVIMLSIIVIHNFAvlglfALENITMAEMF 368
Cdd:PRK10406 320 ALFTVPILSALqnVSSPYAAfGLVMCALLIVSFYT-----SISGILKAEMF 365
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-425 |
4.60e-44 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 157.76 E-value: 4.60e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 17 AVSGWLGTALEFMDFQLYSLGAALVFHEIFFPEQSAAMALILAmgtygAGYIARIVGAFIFGRMGDRIGRKKVLFITITM 96
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFA-----AGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 97 MGICTTLIGVLPTyaqigifaPVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAV 176
Cdd:cd17316 76 FGLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 177 MFFALDreelIAWGWRVPFLASVVVMIFAIWLRmnlkespvfekvndaetiapvaaqdtslgamfksKSFWLATGLRFGQ 256
Cdd:cd17316 148 LIPLLS----GDWGWRILFLIGALPALLALLLR----------------------------------RRTLLLILLWFFI 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 257 AGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRLPYILLNISAIILAYPMLSIIVDKSY 336
Cdd:cd17316 190 SFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPT 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 337 apgvIMLSIIVIHNFAVLGLFALENITMAEMFGSRNRFTRMAISKEAGGLVAVGFGPVLAGIFCNmTGSWWPIVVMLVAY 416
Cdd:cd17316 270 ----LLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS-TGGTGVPALILALL 344
|
....*....
gi 556356000 417 SLIGLVSAL 425
Cdd:cd17316 345 AIVALIVAL 353
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
1-333 |
1.66e-41 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 152.79 E-value: 1.66e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 1 MTQAQPQRSTSDLVKAAVSGwlgTALEFMDFQLYSLGAALVFHeIFFPEQSAAMALILAMGTYGAGYIARIVGAFIFGRM 80
Cdd:PRK15075 4 MTPAASRESKARAILRVTSG---NFLEMFDFFLFGFYATAIAK-TFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 81 GDRIGRKKVLFITITMMGICTTLIGVLPTYAQIGIFAPVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVA 160
Cdd:PRK15075 80 IDRVGRRKGLIVTLSIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 161 MGTNCGTLSATAIWAVMFFALDREELIAWGWRVPFLASVVVMIFAIWLRMNLKESPVFEkvndAETIAPvaaqdtSLGAM 240
Cdd:PRK15075 160 ASQQVAVVFAALLGYLLNQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFL----ARKHRP------SMREI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 241 FKSksfwLATGLRFGQAGNSGLIQTFLAGYL--VQTLLFDKAI----PTDALMISSILG---FLSIPLLGWLSDKMGRRL 311
Cdd:PRK15075 230 FRS----LAANWRIVLAGMLMVAMTTVSFYLitVYTPTFGKTVlhlsAADSLLVTLCVGvsnFIWLPIGGALSDRIGRRP 305
|
330 340
....*....|....*....|..
gi 556356000 312 PYILLNISAIILAYPMLSIIVD 333
Cdd:PRK15075 306 VLIAFTVLAILTAYPALSWLVA 327
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-431 |
2.20e-29 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 118.05 E-value: 2.20e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 15 KAAVSGWLGTALEFMDFQLYSLGAALVFHEIFFPEQSAAMAlilamgtYGAGYIARIVGAFIFGRMGDRIGRKKVLFITI 94
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLL-------ASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 95 TMMGICTTLIGVLPTYAQigifapvlLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIW 174
Cdd:COG2271 83 LLWGLATLLFGFATSFWQ--------LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 175 AVMffaldreeLIAWGWRVPFLASVVVMIFAIWLRmnlkespvfekvndaetiapvaaqdtslgamfksksFWLATGLRF 254
Cdd:COG2271 155 GWL--------LAAFGWRAAFLILGLPGLLLALLR------------------------------------FWLLALAYF 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 255 GQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRLPYILLNISAIILAYPMLSIIVDk 334
Cdd:COG2271 191 LVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLP- 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 335 syaPGVIMLSIIVIHNFAVLGLFALENITMAEMFGSRNRFTRMAISkEAGGLVAVGFGPVLAGIFCNMTGSWWPIVVMLV 414
Cdd:COG2271 270 ---SPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLV-NTFGFLGGALGPLLVGYLLDATGYQAAFLLLAA 345
|
410
....*....|....*..
gi 556356000 415 AYSLIGLVSALLMPEVR 431
Cdd:COG2271 346 LALLAALLALLLLRETR 362
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-429 |
7.47e-29 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 116.90 E-value: 7.47e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 16 AAVSGWLGTALEFMDFQLYSLGAALVFHEIFFPEQSAAMALILAMgtygagyIARIVGAFIFGRMGDRIGRKKVLFITIT 95
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPV-------LVGALLRIPLGFLVDRFGPRRVLLIGLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 96 MMGICTTLIGVLPTYAQigifapvlLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIWA 175
Cdd:COG2223 79 LLGIGLLLLALAVSYWL--------LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 176 VMffaldreeLIAWGWRVPFL-ASVVVMIFAIWLRMNLKESPVFEKvndaetiAPVAAQDTSLGAMFKSKSFWLATGLRF 254
Cdd:COG2223 151 LL--------IAAFGWRNAFLiLGILLLVVAVLAWLFLRDPPAGAA-------AAAKASLRDQLEALRDPRFWLLSLLYF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 255 GQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRLPYILLNISAIILAYPMLSIIVDk 334
Cdd:COG2223 216 GTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGS- 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 335 syAPGVIMLSIIVIhnFAVLGLFALENITMAEMFGSRNRFTRMAISKEAGGLVAVgFGPVLAGIFCNMTGSWWPIVVMLV 414
Cdd:COG2223 295 --LWLFLVLFLLLG--LALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGF-LGPLLFGALLDATGSYTAAFLVFA 369
|
410
....*....|....*
gi 556356000 415 AYSLIGLVSALLMPE 429
Cdd:COG2223 370 VLALVALVLTLLLYR 384
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
21-430 |
4.16e-28 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 115.09 E-value: 4.16e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 21 WLGTALEFMDFQLYSLGA-ALVFHEIFFPEQSAAMALILAMGTygagyiarIVGAFIFGRMGDRIGRKKVLFITITMMGI 99
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLpALIAEFGLDEAEAGLLGTVTLAGG--------AIGGILGGILADRFGRVRVLVITILLFAV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 100 CTTLIGVLPTYAQIGIfapvllvtLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMFF 179
Cdd:cd17371 77 FTLLCGFAQNYWQLLI--------LRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 180 ALDREeliaWGWRVPFLASVVVMIFAIWLRMNLKESPVFEKVNDAETIAPVAAQDTSLGAMFKSKSFWLATGLRFGQAGN 259
Cdd:cd17371 149 LLPPE----IAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 260 SGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRLPYILLNISAIILAYPMLSIIVDKSyapg 339
Cdd:cd17371 225 YYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPT---- 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 340 vIMLSIIVIHNFAVLGLFALENITMAEMFGSRNRFTRMAISKEAGGLVAVGFgPVLAGIFCNMTGSWWPIVVMLVAYSLI 419
Cdd:cd17371 301 -LILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALF-PFLVGFLATSGSLGTAIAVFAAVYYIA 378
|
410
....*....|.
gi 556356000 420 GLVSALLMPEV 430
Cdd:cd17371 379 GLVLALLLPET 389
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
4-301 |
1.91e-24 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 102.58 E-value: 1.91e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 4 AQPQRSTSDLVKAAVSGWLGTALEFMDFQLYSLGAALVFHEifFPEQSAAMALILAmgtygAGYIARIVGAFIFGRMGDR 83
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAAD--LGASSAQLGWIVS-----AYLLGRAIGLLLFGRLGDR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 84 IGRKKVLFITITMMGICTTLIGVLPTyaqigifaPVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGT 163
Cdd:COG0477 76 YGRKRVLLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 164 NCGTLSATAIWAVMffaldreeLIAWGWRVPFLASVVVMIFAIWLRMNLKESPVFEKVNDAETIAPVAAQDTSLGAMFKS 243
Cdd:COG0477 148 GLGLALGPLLGGLL--------VAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALL 219
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 556356000 244 KSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLG 301
Cdd:COG0477 220 LLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLA 277
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-379 |
3.39e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 100.05 E-value: 3.39e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 21 WLGTALEFMDFQLYSLGAALVFHEIFFPEQSAAMALilamgtyGAGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGIC 100
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVV-------TAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 101 TTLIGVLPTYAqigifapvLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMffa 180
Cdd:COG2814 89 SLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL--- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 181 ldreeLIAWGWRVPFLASVVVMIFAIWL-RMNLKESPVFEKvndaetiapvAAQDTSLGAMFKSKSFWLATGLRFGQAGN 259
Cdd:COG2814 158 -----ADLFGWRWVFLVNAVLALLALLLlLRLLPESRPAAR----------ARLRGSLRELLRRPRLLLLLLLAFLLGFG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 260 SGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRlPYILLNISAIILAYPMLSIIvdksyAPG 339
Cdd:COG2814 223 FFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR-RLLLIGLLLLALGLLLLALA-----GSL 296
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 556356000 340 VIMLSIIVIHNFAVLGLFALENITMAEMFGSRNRFTRMAI 379
Cdd:COG2814 297 WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL 336
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
63-427 |
2.31e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 95.34 E-value: 2.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 63 YGAGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQigifapvlLVTLRIIQGLGAGAEISGAGTM 142
Cdd:cd17325 37 VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ--------LLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 143 LAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMFFaldreeliAWGWRVPFLASVVVMIFAIWLRMNLKESPVFEKVN 222
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD--------ALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 223 DAETIAPVAaqdTSLGAMFKSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGW 302
Cdd:cd17325 181 RAVSAARLR---SGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 303 LSDKMGRRlPYILLNISAIILAYPMLsiivdkSYAPGVIMLSIIVIHNFAVLGL-FALENITMAEMFGSRNRFTRMAISK 381
Cdd:cd17325 258 LSDRIGRK-PLILIGLLLSAVALLLL------PLATSFWLLLLLLALLGLGLGLvFPATLALLADIVPPEGRGTAMGLFN 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 556356000 382 EAGGLVAVgFGPVLAGIFCNMTGSWWPIVVMlvaySLIGLVSALLM 427
Cdd:cd17325 331 TAFSLGMV-LGPLLGGFLYDAFGFATPFLAA----AALLLLAAVLF 371
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
21-379 |
3.51e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 85.55 E-value: 3.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 21 WLGTALEFMDFQLYSLGAALVFHEIFfpeQSAAMALILAMGTYGAGYIariVGAFIFGRMGDRIGRKKVLFITITMMGIC 100
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDL---GISPTEIGLLLTLFSLGYA---LAQPLAGRLSDRFGRRRVLLIGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 101 TTLIGVLPTYAqigifapvLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMffa 180
Cdd:pfam07690 76 LLLLLFASSLW--------LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL--- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 181 ldreeLIAWGWRVPFLASVVVMIFAIWLRMNLKESPvfEKVNDAETIAPVAAQDTSLGAMFKSKSFWLATGLRFGQAGNS 260
Cdd:pfam07690 145 -----ASLFGWRAAFLILAILSLLAAVLLLLPRPPP--ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 261 GLiqTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRLPYILLNISAIILAYPMLSIIVDKSYapgV 340
Cdd:pfam07690 218 GL--LTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSS---L 292
|
330 340 350
....*....|....*....|....*....|....*....
gi 556356000 341 IMLSIIVIHNFAVLGLFALENITMAEMFGSRNRFTRMAI 379
Cdd:pfam07690 293 WLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGL 331
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
65-398 |
5.48e-18 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 85.49 E-value: 5.48e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 65 AGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQIGIFapvllvtlRIIQGLGAGAEISGAGTMLA 144
Cdd:TIGR00895 60 AGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLIL--------RFLAGLGLGGLMPNLNALVS 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 145 EYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMffaldreeLIAWGWRVPFL-ASVVVMIFAIWLRMNLKESPVF----- 218
Cdd:TIGR00895 132 EYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWL--------IPVFGWRSLFYvGGIAPLLLLLLLMRFLPESIDFlvskr 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 219 -------------EKVNDAETIAPVAAQDT-----SLGAMFKSKS------FWLATGlrFGQAGNSGLIqTFLAgYLVQT 274
Cdd:TIGR00895 204 petvrrivnaiapQMQAEAQSALPEQKSTQgtkrsVFKALFQGKTaritvlLWLLYF--MLLVGVYFLT-NWLP-KLMVE 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 275 LLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRLPYILLNISAIILaypmlsIIVDKSYAPGVIMLSIIVIHNFAVL 354
Cdd:TIGR00895 280 LGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFA------VLVGSTLFSPTLLLLLGAIAGFFVN 353
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 556356000 355 GLFALENITMAEMFGSRNRFTRMAISKEAGGLVAVgFGPVLAGI 398
Cdd:TIGR00895 354 GGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAI-IGPILAGY 396
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
19-439 |
5.62e-16 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 79.62 E-value: 5.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 19 SGWLGTALEFMDFqlyslgaalVFHEIFFPEQSAAMALILAMG-TYGAGYIARIVGAFIFGRMGDRIGRKKVLFITITMM 97
Cdd:pfam00083 16 TGVIGAFLTLIDF---------FKNFGLSKSVSSLAALSVLSGlIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 98 gicttLIGVLPTYAQIGIFAPVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLsaTAIWAVM 177
Cdd:pfam00083 87 -----VIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGIL--LAYIFGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 178 FFALDREEliaWGWRVPFLASVVVMIFAIWLRMNLKESP--------------VFEKVNDAETIAPVAAQ--DTSLGAMF 241
Cdd:pfam00083 160 GLNKTSNS---DGWRIPLGLQLVPALLLIIGLLFLPESPrwlvekgrleeareVLAKLRGVPDVDRELDEikDSLEAGQE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 242 KSKSFW---LATGLRFGQAGNSGLIQTF--LAGYLVQ----TLLFDKAIPTDALMISSILG---FLSIPLLGWLSDKMGR 309
Cdd:pfam00083 237 AEKASWkelFSTKTRRQRLLIGVMLQIFqqLTGINAIfyysTTIFENLGLSDSFLVTIIVGvvnFVFTFIAIFLVDRFGR 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 310 RLPYIL----LNISAIILAYPMLSIIVDKSYAPGVIMLSI---IVIHNFAVLGLFAlenITMAEMFGSRNRFTRMAISKE 382
Cdd:pfam00083 317 RPLLLLgaagMAICFVILGIVALLGVSKSDWAGIVAIVFIalfIAFFAMGWGPVPW---VIVSELFPLSVRSKAMALATA 393
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 556356000 383 AGGLVAVGFGPVLAGIFCNMTGSW--WPIVVMLVAYSLIGLVsalLMPEVRDRDLSEAE 439
Cdd:pfam00083 394 ANWLANFLIGFLFPIITDAIGLGYtfFIFAGLLVLFIIFVFF---FVPETKGRTLEEID 449
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
15-215 |
9.79e-16 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 79.36 E-value: 9.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 15 KAAVSGWLGTALEFMDFQLYSLGAALVFHEiFFPEQSAAMALIlamgtyGAGYIARIVGAFIFGRMGDRIGRKKVLFITI 94
Cdd:PRK03893 20 KAFSAAWLGYLLDGFDFVLITLVLTEVQGE-FGLTTVQAASLI------SAAFISRWFGGLLLGAMGDRYGRRLAMVISI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 95 TMMGICTTLIGVLPTYAQIGIFapvllvtlRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIW 174
Cdd:PRK03893 93 VLFSVGTLACGFAPGYWTLFIA--------RLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVY 164
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 556356000 175 AVMffaldreeLIAWGWRVPFLASVVVMIFAIWLRMNLKES 215
Cdd:PRK03893 165 SLV--------VPVWGWRALFFIGILPIIFALWLRKNLPEA 197
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
58-324 |
7.54e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 72.58 E-value: 7.54e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 58 LAMGTYGAGYIariVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAqigifapvLLVTLRIIQGLGAGAEIS 137
Cdd:cd17324 38 LLVSAYALGYA---LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 138 GAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMffaldreeLIAWGWRVPFLASVVVM-IFAIWLRMNLKESP 216
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL--------GQLLGWRAAFLAIAVLAlLAALLLWRLLPSLP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 217 VFEKVNDAETiapvaaqdTSLGAMFKSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLS 296
Cdd:cd17324 179 PKKPGSLGLL--------SSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVG 250
|
250 260
....*....|....*....|....*...
gi 556356000 297 IPLLGWLSDKMGRRLPYILLNISAIILA 324
Cdd:cd17324 251 SPLAGRLADRGGRRALLIALLLLAAALL 278
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
63-425 |
3.56e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 70.53 E-value: 3.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 63 YGAGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAqigifapvLLVTLRIIQGLGAGAEISGAGTM 142
Cdd:cd06174 37 FALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW--------LLLLGRFLLGLGSGLIDPAVLAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 143 LAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMFfaldreELIAWGWRVPFLASVVVMIFAIWLRMNLKESPVFEKVN 222
Cdd:cd06174 109 IADLFPERERGRALGLLQAFGSVGGILGPLLGGILA------SSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 223 DAETIAPvAAQDTSLGAMFKSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGW 302
Cdd:cd06174 183 KNEEASS-KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 303 LSDKMGRRLPYILLNISAIILAYPMLSIivdksYAPGVIMLSIIVIHNFAVLGLFALENITMAEMFGSRNRFTRMAISKE 382
Cdd:cd06174 262 LSDRLIGRKPLLLIGLLLMALGLALLLL-----APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNT 336
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 556356000 383 AGGLVAVgFGPVLAGIFCNMTGSWWPIVVMLVAYSLIGLVSAL 425
Cdd:cd06174 337 FGFLGGA-IGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
72-427 |
2.18e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 68.36 E-value: 2.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 72 VGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAqigifapvLLVTLRIIQGLGAGAEISGAGTMLAEYAPKgK 151
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVA--------LLLAGTALIGAGIAVGNVLLPGLIKRWFPD-R 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 152 RGIISSLVAMGTNCGTlsatAIWAVMFFALdreeLIAWGWRVPFLASVVVMIFA--IWLRMNLKESPVfekvndaetiAP 229
Cdd:COG2807 139 VGLMTGLYTAAMGLGA----ALAAGLTVPL----AAALGWRGALAVWALLALLAllLWLPLLRRRPAA----------AA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 230 VAAQDTSLGAMFKSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLfdkaIPTDALMISSILGFLSIP---LLGWLSDK 306
Cdd:COG2807 201 AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGL----SAATAGLLLSLFQLAGIPgslLVPLLADR 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 307 MGRRLPYILLNISAIILAYPMLSiivdksYAPGVIMLSIIVIHNFAVLGLFALENITMAEMFGSRNRFTR-MAISKEAGG 385
Cdd:COG2807 277 LGDRRPLLLLLGLLGLAGLLGLL------LAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAAlSGMAQSVGY 350
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 556356000 386 LVAvGFGPVLAGIFCNMTGSWWPIVVMLVAYSLIGLVSALLM 427
Cdd:COG2807 351 LLA-ALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
68-427 |
5.56e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 67.23 E-value: 5.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 68 IARIVGAF---IFGRMGDRIG-----RKKVLFITITMMGICTTLIGVLPTYAQIGIFapVLLVTLRIIQGLGAGAEISGA 139
Cdd:COG2211 54 VARLWDAItdpLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSPTGKL--IYALVTYLLLGLAYTLVNIPY 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 140 GTMLAEYAPKGK-RGIISSLVAMGTNCGTLSATAIWAVMFFALDREEliAWGWRVPFL-ASVVVMIFAIWLRMNLKESPV 217
Cdd:COG2211 132 SALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA--ALGYRLTALiFAVLGLLAFLLTFFGTKERPV 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 218 FEkvndaETIAPVAAqdtSLGAMFKSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSI 297
Cdd:COG2211 210 PE-----EEKVSLKE---SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGA 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 298 PLLGWLSDKMGRRLPYILLNISAIILAYPMLSIivdkSYAPGVIMLSIIVIHNFAVLGLFALENITMAEM-------FGS 370
Cdd:COG2211 282 PLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFL----GPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydewkTGR 357
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556356000 371 RNRFTRMAI----SKEAGGLVAVGFGPVLA--GIFCNMTGSWWPIVVMLVAYSLIGLVSALLM 427
Cdd:COG2211 358 RREGLYFGIftfaIKLGQALAGALAGLLLAlfGYVAGAAQSPSALTGIRLLFFLLPAVLLLLA 420
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
72-437 |
6.74e-12 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 67.35 E-value: 6.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 72 VGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYaqigifaPVLLVtLRIIQGLGAGAEISGAGTMLAEYAPKGK 151
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY-------TVFLV-FRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 152 RGIisslvamgtnCGTLSATAiWAVMFFALdreELIAW---GWRVPFLASVVVMIFAIWLRMNLKESPVF----EKVNDA 224
Cdd:TIGR00898 214 RAI----------VGTLIQVF-FSLGLVLL---PLVAYfipDWRWLQLAVSLPTFLFFLLSWFVPESPRWlisqGRIEEA 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 225 ETIAPVAAQ--DTSLGAMFKSKSFWLATGLRFGQAGNSGLIQT--------------FLAGYLVQTLLFD-KAIPTDALM 287
Cdd:TIGR00898 280 LKILQRIAKinGKKLPAEVLSLSLEKDLSSSKKQYSFLDLFRTpnlrkttlclmmlwFTTAFSYYGLVLDlGNLGGNIYL 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 288 ISSILGFLSIP--LLGWLS-DKMGRRLPYILLNISAIILAYPMLSIIVDKSYapgvIMLSIIVIHNFAVLGLFALENITM 364
Cdd:TIGR00898 360 DLFISGLVELPakLITLLLiDRLGRRYTMAASLLLAGVALLLLLFVPVDLYF----LRTALAVLGKFGITSAFQMVYLYT 435
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556356000 365 AEMFGSRNRFTRMAISKEAGGLvavgfGPVLAGIFCNMTGSWW--PIVVMLVAYSLIGLVSALLmPEVRDRDLSE 437
Cdd:TIGR00898 436 AELYPTVVRNLGVGVCSTMARV-----GSIISPFLVYLGEKWLflPLVLFGGLALLAGILTLFL-PETKGVPLPE 504
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
64-434 |
1.53e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 65.30 E-value: 1.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 64 GAGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQIGIfapvllvtLRIIQGLGAGAEISGAGTML 143
Cdd:cd17365 41 SAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL--------LRFLTGLGLGAAMPNAITLV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 144 AEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMffaldreeLIAWGWRVPFLASVVVMIFAiwlrmnlkespvfekvnd 223
Cdd:cd17365 113 SEYAPARRRSLAVTLMFCGYPLGAALGGFLAAAL--------IPAFGWRSVFLLGGVPPLIL------------------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 224 aetiapvaaqdtsLGAMFKSKSFWLATGLrfgqagnsGLIQTFLAGYLVQTLLFDKAIPT-DALMISSIL---GFLSIPL 299
Cdd:cd17365 167 -------------LPLLRGTLLLWVTFFM--------GLLLVYLLNSWLPKLMVEAGYSLsQALTITLLLnigGVIGSLL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 300 LGWLSDkmgRRLPYILLNISAIILAYPMLSIIVdkSYAPGVIMLSIIVIHNFAVLGLFALENITMAEMFGSRNRFTRMAI 379
Cdd:cd17365 226 LGWLAD---RFGPKRVLALFFALGAVSLALLGV--SPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGW 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 556356000 380 SKEAGGLVAVgFGPVLAGIfcnMTGSWWPIVVMLVAYSLIGLVSALLMPEVRDRD 434
Cdd:cd17365 301 ALGVGRLGAI-LGPLLGGL---LLAAGLGPESVFLALAIPAALGALAVLLLRLRR 351
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
64-348 |
2.63e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 64.92 E-value: 2.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 64 GAGYIARIVGAFIFGRMGDRIGRKKVLFITItmmgicttLIGVLPTYAQIGIFAPVLLVTLRIIQGLGAGAEISGAGTML 143
Cdd:cd17489 38 GLFTLAALLARPFAGRLLDRFGRKRLLLIGL--------LIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 144 AEYAPKGKRGIISSLVAMGTNCGTL--SATAIWAVMFfaldreeliaWGWRVPFLASVVVMIFAIWLRMNLKESPVfekv 221
Cdd:cd17489 110 ADIIPPSRRGEGIGYYGLATTLAMAlgPALGLFLYQH----------LGFAVLFIVAAVLALLALLLVFLVKDPPP---- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 222 ndaeTIAPVAAQDTSLGAMFKSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAIptdALMISSILGFLSIPLLG 301
Cdd:cd17489 176 ----VAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGL---FFTVYAIALLLSRPFSG 248
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 556356000 302 WLSDKMGRRlpyILLNISAIILAYPMLSIivdkSYAPGVIMLSIIVI 348
Cdd:cd17489 249 KLSDRKGPK---TVIIPGLLLLALGLLLL----SFAGSPWMLLLAAV 288
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
76-404 |
4.12e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 64.56 E-value: 4.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 76 IFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQigifapvlLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGII 155
Cdd:cd17328 53 IFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ--------LLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 156 SSLVAMGTNCGtlsaTAIWAVMFFALDREELiawGWRVPFLASVVVM-IFAIWLRMNLKESP--VFEKVNDAETIAPVAA 232
Cdd:cd17328 125 LGVFYFAIPLG----SGLGYVVGGLVAQATG---GWRWAFRVTGVLGvLLAILLLLFVREPPrgAAEGGVMAKSTATSFL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 233 QDTSlgAMFKSKSFWL----ATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMG 308
Cdd:cd17328 198 ADLK--ALAKNPSFILstlgFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 309 RRLPYILLNISAIIL---AYPMLSIIV--DKSYAPGVIMLSIIVIHNFAVLGLFAleNITMAEMFGSRnRFTRMAISKEA 383
Cdd:cd17328 276 RKTPRADPLVCAVGLlaaAPFLFLALVlaLSNLLLAWVLLFLGEFLLSLNWAPVF--AILLYVVIPTR-RSTASAIQILL 352
|
330 340
....*....|....*....|.
gi 556356000 384 GGLVAVGFGPVLAGIFCNMTG 404
Cdd:cd17328 353 SHLLGDAGSPYLIGLISDLLR 373
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
64-419 |
1.80e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 62.26 E-value: 1.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 64 GAGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYaqigifaPVLLVTLrIIQGLGAGAEISGAGTML 143
Cdd:cd17475 38 SALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSY-------PVLLVLL-FLVGAGYGSVQPGGGRAI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 144 AEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMFFALdreeliawGWRVPFLAS-VVVMIFAIWLRMNLKESPVFekvn 222
Cdd:cd17475 110 MRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHY--------GWRAAFVVAgLVSILAAVLFWLFYREPPAA---- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 223 dAETIAPVAAQDTSLGAMFKSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGW 302
Cdd:cd17475 178 -SAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 303 LSDKM--GRRLPYILLNISAIILAYPMLSIIVDKSYAPGVIMLSIIVihNFAVLGLFALENITMAEMFGSRNRFTRMAIS 380
Cdd:cd17475 257 VSDRVfgGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILL--GLFAIGWNGLYLTLVAESAGPEQAGTALGLA 334
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 556356000 381 KeAGGLVAVGFGPVLAGIFCNMTGS----WWPIVVMLVAYSLI 419
Cdd:cd17475 335 N-TINFIGIAIGPPLFGLLVDATHSyapaWLALALLLVLAALL 376
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
6-356 |
3.06e-10 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 61.87 E-value: 3.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 6 PQRstsdlvKAAVSGWLGTALEFMDFQLyslgaalVFHEIFFPEQSAAMALILAMGTYGAGYIARIVGAFIFGRMGDRIG 85
Cdd:PRK12307 15 PQK------NALFSAWLGYVFDGFDFML-------IFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 86 RKKVLFITITMMGICTTLIGVLPTYaqigifapVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNC 165
Cdd:PRK12307 82 RKPLMMWSIVAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 166 GTLSATAIwaVMFFALdreeliAWGWRVPFLASVVVMIFAIWLRMNLKESPVFE--KVNDAETIAPVAAQDTSLG--AMF 241
Cdd:PRK12307 154 GNIIAAYF--MPSFAE------AYGWRAAFFVGLLPVLLVIYIRARAPESKEWEeaKLSGKGKHSQSAWSVFSLSmkGLF 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 242 KSKSF------WLATGLRFGQAGN-SGLIQTFLAGYLVQTLLFDKaiptdaLMISSILG-FLSIPLLGWLSDKMGRRLPY 313
Cdd:PRK12307 226 NRAQFpltlcvFIVLFSIFGANWPiFGLLPTYLAGEGFDTGVVSN------LMTAAAFGtVLGNIVWGLCADRIGLKKTF 299
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 556356000 314 ILLNISAIILAYPMLSIIVDKSYAPGVIMLSIIVIhNFAVLGL 356
Cdd:PRK12307 300 SIGLLMSFLFIFPLFRIPQDNYLLLGACLFGLMAT-NVGVGGL 341
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
63-212 |
3.42e-10 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 61.52 E-value: 3.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 63 YGAGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQIGIFApvLLVTLRIIQGLGAGAEISGAGTM 142
Cdd:cd17364 45 NAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGVMG--WLIFFRFLLGIGIGGDYPLSATI 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556356000 143 LAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMFFALDREELIAW------GWRVPFLASVVVMIFAIWLRMNL 212
Cdd:cd17364 123 MSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAIFEHPLPAGTyhhadlVWRIVLGLGAIPALSVLYFRKHL 198
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
71-426 |
3.69e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 61.43 E-value: 3.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 71 IVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAqigifapvLLVTLRIIQGLGAGAEISGAGTMLAEYAPKG 150
Cdd:cd17474 48 AVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA--------LLLAGRALQGIGAAGLGPLALTLIGDLFEGG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 151 KRGIISSLVAMGTNCGTLSATAIWAVmffaldreeLIAWGWRVPFLASVVVMIFAIWLRMNLKESPvfekvnDAETIAPV 230
Cdd:cd17474 120 ERAKAMGLYEAALGLGIAVGPLLGGL---------LAAISWRYPFFLLAALIPVAFLAILFLLPEP------KEKAKSSS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 231 AAQDTSLGAMFKSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRR 310
Cdd:cd17474 185 ATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 311 LpyILLNISAIILAYPMLSIIVDKSYApgvIMLSIIVIHNFAVLGLFALENITMAEMFGSRNRFTRMAISkEAGGLVAVG 390
Cdd:cd17474 265 R--RILVIGLLLYALSLLLLGFVPSLA---LLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLY-NFVRFLGQA 338
|
330 340 350
....*....|....*....|....*....|....*.
gi 556356000 391 FGPVLAGIFcnmtGSWWPIVVMLVAYSLIGLVSALL 426
Cdd:cd17474 339 VGPLLFGLL----LEIFGLSAPFLVGAAIALAAAVL 370
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
74-426 |
6.00e-10 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 60.70 E-value: 6.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 74 AFIFGRMGDRIGRKKVLFITITMMGICTTLIGvlptyaqIGIFAPVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKgKRG 153
Cdd:cd17353 55 APFAGRLVDRGGPRKAILIGGILFGLGFILSA-------FAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPD-KRG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 154 IISSLVAMGTNCGTLSATAIWAVMFFALDREE-LIAWGwrVPFLasVVVMIFAIWLRMNLKESPVFEKVNDAETIAPvAA 232
Cdd:cd17353 127 LATGIVIAGFGLGSLIFSPLIAYLINTVGVPTtFLILG--IIFL--IIIVIGAFLIRDPPKGWVPPGVDPLANNAEN-SP 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 233 QDTSLGAMFKSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRLP 312
Cdd:cd17353 202 RDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNT 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 313 YILLNISAIILaypMLSIIVDKSYAPGVIMLSIIVIHNFAvlGLFALENITMAEMFGSRNRFTRMAI---SKEAGGLVav 389
Cdd:cd17353 282 LSIAFLIQGVA---MFLLPFIGSVAVLFVLGVALIGFCYG--GGFALFPALTADFFGTKNAGTNYGLlytAKGVGGLI-- 354
|
330 340 350
....*....|....*....|....*....|....*..
gi 556356000 390 gfGPVLAGIFCNmTGSWWPIVVMLVAYSLIGLVSALL 426
Cdd:cd17353 355 --GPIIAAYVLY-TGGYNAAFIIAAALSLVALALALL 388
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
53-427 |
1.12e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 59.89 E-value: 1.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 53 AMALILAMGTYGAGY-IARIVGafifGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQigifapvlLVTLRIIQGLG 131
Cdd:cd17319 37 PTQYGLIASAFFLGYaLFQVPG----GWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTS--------LYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 132 AGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMffaldreeLIAWGWRVPFLA-SVVVMIFAIWLRM 210
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL--------LLLFGWRWAFIIeGLLGLLLAVLWWF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 211 NLkespvfekvndaetiapvaaqdtslgamfksKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDkaiPTDALMISS 290
Cdd:cd17319 177 YL-------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFS---LKQVGLLAA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 291 I---LGFLSIPLLGWLSDKM--GRRLPYILlnISAIILAYPMLSIIVDKSYAPGVIMLSIIVIHNFAVLGLFAlenITMA 365
Cdd:cd17319 223 IpflAGAIGMILGGRLSDRLlrGARRLVII--IGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFW---SLPA 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556356000 366 EMFGSRNRFTRMAISKeAGGLVAVGFGPVLAGIFCNMTGSWWPIVVMLVAYSLIGLVSALLM 427
Cdd:cd17319 298 DLLPGEAAATAGGLIN-SGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
65-433 |
1.18e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 59.87 E-value: 1.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 65 AGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAqigifapvLLVTLRIIQGLGAGAEISGAGTMLA 144
Cdd:COG0738 51 AFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP--------LLLLALFLLGLGLGLLDVAANPYVA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 145 EYAPKGKRGIISSLVAMgTNCGTLSATAIwavMFFALDREELIAWGWRVPFLASVVVMIFAIWLRMNLKESpvfekvndA 224
Cdd:COG0738 123 ALGPETAASRLNLLHAF-FSLGALLGPLL---GGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEI--------E 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 225 ETIAPVAAQDTSLGAMFKSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLS 304
Cdd:COG0738 191 EEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 305 DKMGRRLpyiLLNISAIILAYPMLSIIVDKSYAPGVIMlsiivihnFAVLGLFAleNITMAEMFGSRNRFTRMAISKEAG 384
Cdd:COG0738 271 KRFGPVR---LLRLSALLAAVGLLLALLAPGPWLALIG--------LALVGLGL--SLMFPTIFSLALDGLGKRTAAAVS 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 556356000 385 GLVAVG-----FGPVLAGIFCNMTGSWWPIVVMLVAYSLIGLVSALLMPEVRDR 433
Cdd:COG0738 338 AVLIMGivggaIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
61-205 |
5.97e-09 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 54.58 E-value: 5.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 61 GTYGAGY-IARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQigifapvlLVTLRIIQGLGAGAEISGA 139
Cdd:TIGR00880 1 GLLLAGYaLGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITV--------LIIARFLQGFGAAFALVAG 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556356000 140 GTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMFfaldreelIAWGWRVPFLASVVVMIFA 205
Cdd:TIGR00880 73 AALIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLA--------QFLGWRAPFLFLAILALAA 130
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
63-425 |
7.52e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 57.28 E-value: 7.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 63 YGAGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQigifapvLLVTLRIIQGLGAGAEISGAGTM 142
Cdd:cd17355 44 FTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQ-------LYLLWGLLGGGGAGTLAAVAFAT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 143 LAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMffaldreeLIAWGWRVPFLASVVVMIFAIWLRMNLKESPVFEKVN 222
Cdd:cd17355 117 VAAWWFERRRGLALGILTAGGGLGSLVFLPLGAAL--------IEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLAL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 223 DAETIAPVAAQDTSLGAMFKSKSFW-LATGLRFGQAGNSGLIQTFLAgyLVQTLLFDKAIPTDALMISSILGFLSIPLLG 301
Cdd:cd17355 189 RAYDDASPASPGSTLKEALRSASFWlLALAFFLCGFAVVGLIVHLVP--YLADRGISPAAAAVALALIGLFNIVGRLLSG 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 302 WLSDKMGRRLP-YILLNISAIILAYPMLSIivdksyAPGVIMLSIIVIHNFAVLGLFALENITMAEMFGSRNRFTRMAIS 380
Cdd:cd17355 267 WLGDRYSPRRLlAASYALRALGLALLLLLP------FPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLV 340
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 556356000 381 kEAGGLVAVGFGPVLAGIFCNMTGSWWPIVVMLVAYSLIGLVSAL 425
Cdd:cd17355 341 -FAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
67-218 |
5.25e-08 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 54.96 E-value: 5.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 67 YIARIVGAFIFGRMGDRIGRKKVLFITITMMgicttLIGVLPTYAQIGIFAPVLLVTLRIIQGLGAGAEISGAGTMLAEY 146
Cdd:cd17357 59 FIGGAIGSFISAFLANRFGRKNGLLISNALL-----VVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEI 133
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556356000 147 APKGKRGIISSLVAMGTNCGTLSATAIwaVMFFALDREELIAWGWRVPFLASVVVMIFAIWlrmnLKESPVF 218
Cdd:cd17357 134 SPSELRGALGSLTQIGVTLGILLGQVF--GLPSVLGTETLWPYLLFFPGIPALLQLAALPF----FPESPKF 199
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
68-437 |
6.44e-08 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 54.50 E-value: 6.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 68 IARIVGAFIFGRMGDRIGRKKVLFItitmMGICTTLIGVLPTYAQigifAPVLLVTLRIIQGLGAGAEISGAGTMLAEYA 147
Cdd:cd17358 52 LGALIGALLSGKLADRIGRKRTLLI----SAIPCILGWLLIAFAK----DVWMLYLGRFLAGFGGGAASVVVPVYIAEIA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 148 PKGKRGIISSLVAMGTNCGTLSATAIWAVMFFALdreelIAWGWRVPFLASVVVMIFaiwlrmnLKESPVF--------- 218
Cdd:cd17358 124 PKNVRGALGSLNQLLVNIGILLGYVLGSFLPWRT-----LALIGAIPPVVFLILLFF-------IPESPRWlakkgreee 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 219 ----------EKVNDAETIAPVAAQDTSLGAMFKS------------KSFWLATGLRFGQ--AGNSGLIQtflagYLVQt 274
Cdd:cd17358 192 aekslqflrgKDADISKEAAEIQEELAELEKEAKEssfsdlfqrkylKPLVIGLGLMLFQqlSGINAVIF-----YASS- 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 275 lLFDKA----IPTDALMISSILGFLSIPLLGWLSDKMGRRlpyILLNISAIILAYPMLSI------------IVDKSYAP 338
Cdd:cd17358 266 -IFDEAgsglDPNTATIIIGVVQVVGTLVATLLVDRLGRR---PLLLVSAIGMGIGLLALglyfylqehgalLSSVSWLP 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 339 GVIMLSIIVIHNFAVLGLFAlenITMAEMFGSRNRFTrmaiskeAGGLVAV---GFGPVLAGIFCNMTGSWWPIVVMLV- 414
Cdd:cd17358 342 LVGLVIYIISFSIGLGPLPW---VIMSEIFPAKIKGL-------AGSLVTLvnwLFAFIVTKTFPFLTLAWGASGTFWIf 411
|
410 420
....*....|....*....|....*
gi 556356000 415 -AYSLIGLV-SALLMPEVRDRDLSE 437
Cdd:cd17358 412 aGICGLALVfVLLFVPETKGKSLEE 436
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
65-348 |
1.90e-07 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 53.01 E-value: 1.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 65 AGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTY-AQIGIFApVLLVTLRIIQGLGAGAeisgAGTML 143
Cdd:cd17345 46 ALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSAtSSVGLMF-ILLFLNGWFQGMGWPP----SGRTM 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 144 AEYAPKGKRGIISSLVAMGTNCGT--LSATAIWAVMFFALDreeliawGWRVPFL-ASVVVMIFAIWLRMNLKESP---- 216
Cdd:cd17345 121 VHWFSKKERGTWTSIWNISHNVGGglVGPLAGLGLAIFGDG-------WWRGAFIfPAIIAIIVAVIVLFLGKDTPeseg 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 217 ---VFEKVNDAETIAPVAAQDTSLGA-------MFKSKSFWLATG-------LRFGqagnsglIQTFLAGYLVQTLLFDK 279
Cdd:cd17345 194 lppIEEYKGDYPEEADGEEEEQELSAweifvkyVLKNKLLWYIAIanvfvylVRYG-------ILDWAPTYLSEVKGFSK 266
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556356000 280 AIPTDALMISSILGFLSIPLLGWLSDKM--GRRLPyilLNISAIILaypMLSIIVDKSYAPGVIMLSIIVI 348
Cdd:cd17345 267 AQAMWAFSLFEWAAIPGTLLAGWLSDKLfkGRRAP---TGIIFMIL---VIVALIVYWLAPNVLVDLIALI 331
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
67-218 |
2.30e-07 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 53.44 E-value: 2.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 67 YIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYaqiGIFapvllVTLRIIQGLGAGAEISGAGTMLAEY 146
Cdd:TIGR01299 212 YLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGY---GFF-----LFCRLLSGFGIGGAIPIVFSYFAEF 283
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556356000 147 APKGKRGIISSLVAMGTNCGTLSATAI-WAVM-FFALDREELIAW---GWRVPFLASVVVMIFAIWLRMNLKESPVF 218
Cdd:TIGR01299 284 LAQEKRGEHLSWLCMFWMIGGIYAAAMaWAIIpHYGWSFQMGSAYqfhSWRVFVIVCAFPCVFAIGALTFMPESPRF 360
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
64-437 |
3.06e-07 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 52.81 E-value: 3.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 64 GAGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQIGIFApvLLVTLRIIQGLGAGAEISGAGTML 143
Cdd:TIGR00887 63 GSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSAIIT 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 144 AEYAPKGKRGIISSLVAMGTNCGTLSAtAIWAVMFFALDREELIAWG----------------WRVPFLASVVVMIFAIW 207
Cdd:TIGR00887 141 SEFATKKWRGAMMAAVFAMQGFGILAG-AIVALIVLAGFKHSLEAAAdeasctgscvpavdymWRILIGFGAVPALLALY 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 208 LRMNLKESPvfEKVNDAETIAPVAAQDTSLGAMFKS-----KSFWLATGLRFGQAGNSGLIQTF--------LAGYLVQT 274
Cdd:TIGR00887 220 FRLTIPETP--RYTADVAKDVEQAASDMSAVLQVKIeaepdEVEKASTAVEVPKASWSDFFTHFfkwrhgkhLLGTAGSW 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 275 LLFDKA-----------------IPTDALMIS------SILGFLSIPLLG-----WLS----DKMGRR----LPYILLNI 318
Cdd:TIGR00887 298 FLLDIAfygvnlnqkvilsaigySPPAATNNAyeelykTAVGNLIIALAGtvpgyWVTvflvDIIGRKpiqlMGFFILTV 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 319 SAIILAYPMlsiivdKSYAPGVIMLSIIVIHNFAVLGLFALENITMAEMFGSRNRFTRMAISKEAGGLVAV----GFGPv 394
Cdd:TIGR00887 378 LFFVLGFAY------NHLSTHGFLAIYVLAQFFANFGPNATTFIVPGEVFPTRYRSTAHGISAASGKAGAIigqfGFLY- 450
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 556356000 395 LAGIFC----NMTGSWWPIVV-MLVAYSLIGLVSALLMPEVRDRDLSE 437
Cdd:TIGR00887 451 LAQHGDptkgYPTGIWMGHVLeIFALFMFLGILFTLLIPETKGKSLEE 498
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
61-415 |
1.24e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 50.31 E-value: 1.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 61 GTYGAGYIariVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIgvlPTYAQIGIfapVLLVTLRIIQGLGAGAEISGAG 140
Cdd:cd17318 63 SSFFYGYI---LTQIPGGYLAEKYGAKRVLGYSILITALLTLLT---PLAARGGY---GALIVLRILQGLAQGVTFPAMH 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 141 TMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMFfaldreELIAWGWRVPFLASVVVMIFAIWlrmnlkespvfek 220
Cdd:cd17318 134 ALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLC------ESLGWPSIFYIFGGLGLLWCLLW------------- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 221 vndaetiapvaaqdtslgaMFKSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFD-------KAIPTDALMISSILG 293
Cdd:cd17318 195 -------------------FFLVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNiksngflSSLPYLAMWICSIVG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 294 flsipllGWLSDKMGRRLPYILLNI----SAIILAYPMLSII----VDKSYAPGVIMLSIIVIHNFAVLGLFALENITMA 365
Cdd:cd17318 256 -------GYLADWLRSRGILSTTTVrklfTSIGFLGPGVFLIalgyLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLA 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 556356000 366 EMFGSrnrfTRMAISKEAGGLVAVgFGPVLAGIFC--NMTGSWWPIVVMLVA 415
Cdd:cd17318 329 PNYAG----TLMGITNTAATIAGI-ISPLIVGAIVknDQTIGQWRIVFFISA 375
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
72-178 |
1.34e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 50.27 E-value: 1.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 72 VGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAqigifapvLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGK 151
Cdd:cd17317 40 IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100
....*....|....*....|....*..
gi 556356000 152 RGIISSLVAMGTNCGTLSaTAIWAVMF 178
Cdd:cd17317 112 RSFVGILFGLFWALGYML-LALLAYLI 137
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
39-206 |
1.58e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 49.85 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 39 ALVFHEIFFPEQSAAMALILAMGTYGagyiariVGAFIFGRMGDRIGRKKVLFITItmmgicttLIGVLPTYAQIGIFAP 118
Cdd:cd17370 223 ILRAQELGLSAALIPLLYALFNLVYA-------LAAYPAGRLSDRIGRKKLLILGY--------LSLALAYLGFALGSSL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 119 VLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIwavMFFALDReeliaWGWRVPFLAS 198
Cdd:cd17370 288 WLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLI---AGYLWDL-----ISPSAAFLFS 359
|
....*...
gi 556356000 199 VVVMIFAI 206
Cdd:cd17370 360 AVLALIAL 367
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
76-312 |
2.32e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 49.48 E-value: 2.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 76 IFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTyaqigifaPVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGII 155
Cdd:cd17321 50 LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 156 SSLVAMGTNCGTLSATAIWAVMffaldreeLIAWGWRVPFLASVVVMIFAIWLrmnlkespvfekvndaetiapvaaqdt 235
Cdd:cd17321 122 LGLWGAVVGIGAALGPLLGGLL--------LELFGWRWIFLINVPIGLVALLL--------------------------- 166
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556356000 236 slgamfkSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRLP 312
Cdd:cd17321 167 -------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLV 236
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
76-426 |
3.01e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.09 E-value: 3.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 76 IFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQIGIFApvllvtlrIIQGLGAGAEISGAGTMLAEYAPkGKRGII 155
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV--------ALAGIGSAAFHPEGARLASQAAG-GRRGLA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 156 SSLVAMGTNCGT--LSATAIWAVMFFAldreeLIAWGWRVPFLASVVVMIFAIWLRMNLKESPvfekvndaETIAPVAAQ 233
Cdd:cd17478 121 MSIFSVGGNLGFalGPLIAAALVALFG-----GLGLLILLIIPGLAVALLLLRLRPLKKPEAK--------KAAAKSSAR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 234 DTSLGAMFKSKSFWLATGLR-FGQAGnsglIQTFLAGYLVQTlLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRLP 312
Cdd:cd17478 188 STLKGVWRALLLLLIIVFLRsWVLSS----LTTFLPFYLVQR-GYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRV 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 313 YILLNISAIILAYPMLsiivdksYAPGVIMLSIIVIHNFAVLGLFALeNITMAEMFGSRNRFTrmaiskeAGGLVaVGFG 392
Cdd:cd17478 263 IIASLLLAAPFLLLFL-------LTPGIWSYILLVLAGFLLFASFPV-TVVLAQELLPGNVGL-------ASGLM-MGLS 326
|
330 340 350
....*....|....*....|....*....|....*..
gi 556356000 393 PVLAGIFCNMTGS---WWPIVVMLVAYSLIGLVSALL 426
Cdd:cd17478 327 FGLGGIGAPVLGAladAFGLESVLLILALLPLLGALL 363
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
67-218 |
3.26e-06 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 49.26 E-value: 3.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 67 YIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQigifapvlLVTLRIIQGLGAGAEISGAGTMLAEY 146
Cdd:cd17439 44 YLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGT--------FLFCRLLSGVGIGGSIPIVFSYFSEF 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556356000 147 APKGKRGIISSLVAMGTNCGTLSATAI-WAVM-FFALDREELIAW---GWRVPFLASVVVMIFAIWLRMNLKESPVF 218
Cdd:cd17439 116 LAQEKRGEHLSWLCMFWMIGGIYASAMaWAIIpHYGWSFQMGSAYqfhSWRVFVLVCAFPSVFAIGALTTMPESPRF 192
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
71-380 |
3.36e-06 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 49.11 E-value: 3.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 71 IVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQigifapvlLVTLRIIQGLGAGAEISGAGTMLAEYAPKG 150
Cdd:cd17315 48 AIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV--------LIVGRFLLGLGVGLASVLVPLYISEIAPAK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 151 KRGIISSLVAMGTNCGTLSAtaiwavMFFALDREELIAWGWRVPFLASVVVMIFAIWLRMNLKESPVFekvndaetiapv 230
Cdd:cd17315 120 IRGALGTLNQLMITFGILLA------YLLGLALSLSPPGWWRLMFALAAVPALLQLLLMFFLPESRAL------------ 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 231 aaqdtSLGAMfksksfwlatgLRFGQ--AGNSGLIqtflagYLVQTLLFDKAIPTDALMISSILG---FLSIPLLGWLSD 305
Cdd:cd17315 182 -----LVGVG-----------LQLLQqlTGINAVM------YYAPTIFKSAGGGTASILASIIVGvvnLLATLVAIRLVD 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556356000 306 KMGRR----LPYILLNISAIILAYPMLsIIVDKSYAPGVIMLSIIVIHNFAVLGLFALENITMAEMFGSRNRFTRMAIS 380
Cdd:cd17315 240 KVGRRplllIGFAGMAASLLLLAIAFL-LPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIA 317
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
54-427 |
3.49e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.15 E-value: 3.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 54 MALILAMGTYGAGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLptyaqigiFAPVLLVTLRIIQGLGAG 133
Cdd:cd17329 32 LSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA--------HSPWLFAIALVLTGFGGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 134 AEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMFfaldreeliAWGWRVPFLASVVVM-IFAIWLRMNL 212
Cdd:cd17329 104 LFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL---------LYSFRLLFLAAAVLFlLAALVLLFLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 213 KESPVFEKVNDAETIAPvaaqdtSLGAMFKSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSIL 292
Cdd:cd17329 175 PETRPKRRAAEKTEILR------GYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 293 GFLSIPLLGWLSDKMGRRLpyiLLNISAIILAYPMLSIIVDKSYAPGVIMLSIIVIhnfAVLGLFALENITMAEMFGSRN 372
Cdd:cd17329 249 IVLLQFPVARLVERFRLRK---ILMIGILLFAIGFAVLAFANTLAVLILAMIVLTL---GEMLVFPAVQTLVAALAPPDK 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 556356000 373 RFTRMAISKEAGGLvAVGFGPVLAGIFCNMTGSWWPIVVMLvaysLIGLVSALLM 427
Cdd:cd17329 323 RGSYMGFYALAWGL-GRAIGPLVGGLLLDLLGPGLPWLILA----ALGLIAAALL 372
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
63-233 |
3.50e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 49.19 E-value: 3.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 63 YGAGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQigifapvlLVTLRIIQGLGAGAEISGAGTM 142
Cdd:PRK11551 56 FSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--------LLVARLLTGVGLGGALPNLIAL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 143 LAEYAPKGKRGIISSLVAMGTNCGTLSATAIwaVMFFALDREeliawgWRVPFLASVVVMIFAIWLRMN-LKESPVFEKV 221
Cdd:PRK11551 128 TSEAVGPRLRGTAVSLMYCGVPFGGALASVI--GVLAAGDAA------WRHIFYVGGVGPLLLVPLLMRwLPESRAFAQA 199
|
170
....*....|..
gi 556356000 222 NDAETIAPVAAQ 233
Cdd:PRK11551 200 AGAGKQRAPVLR 211
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
71-216 |
7.89e-06 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 47.95 E-value: 7.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 71 IVGAFIFGRMGDRIGRKKVLFItitmmgicttlIGVLPTYAQIGI-FAPVL--LVTLRIIQGLGAGAEISGAGTMLAEYA 147
Cdd:cd17359 50 AIGALFAGRLADRFGRRKTLLI-----------SAVLFFISALGSaFSPNFtiFIIARIIGGLAVGGASALVPMYIAEVA 118
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556356000 148 PKGKRGIISSLVAMGTNCGTLSATAIWAVMFFALDREELIAWGWRVPFLASVVVMIFAIWLRMNLKESP 216
Cdd:cd17359 119 PAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESP 187
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
65-422 |
9.61e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.55 E-value: 9.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 65 AGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTyaqigifaPVLLVTLRIIQGLGAGAEISGAGTMLA 144
Cdd:cd17477 39 AYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS--------PWVWFLLRFVMGIGLAGLFVVSESWLN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 145 EYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMFFALDReeliawgwrvPFLASVVVMIFAIWLrmnlkespvfekVNDA 224
Cdd:cd17477 111 ALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL----------PFLIAAVLLLLALVP------------LLLT 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 225 ETIAPVAAQDTSLGAMFKSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAIptdALMISSIL--GFLSIPLLGW 302
Cdd:cd17477 169 RRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQA---ALLLAAFVlgGLLLQWPLGW 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 303 LSDKMGRRLPYILLNISAIILAYPMLSIIvdksyAPGVIMLSIIVIHNFAVLGLFALENITMAEMFGSRNRF---TRMAI 379
Cdd:cd17477 246 LADRFDRRRVLLGCALLGALAALLLPLVP-----GLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVaanAALLL 320
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 556356000 380 SKEAGGLVavgfGPVLAGIFCNMTGSWWPIVVMLVAYSLIGLV 422
Cdd:cd17477 321 LYGLGSVI----GPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
71-153 |
1.36e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 47.07 E-value: 1.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 71 IVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQIGIFAPVLlvtlriiqGLGAGAEISGAGTMLAEYAPKG 150
Cdd:COG2270 288 ALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLI--------GLVMGGIQALSRSLLARLIPPG 359
|
...
gi 556356000 151 KRG 153
Cdd:COG2270 360 REA 362
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
71-315 |
2.50e-05 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 46.47 E-value: 2.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 71 IVGAFIFGRMGDRIGRKKVLFItitmmGICTTLIGVLPTYAQIGIFAPVLLVtlRIIQGLGAGAEISGAGTMLAEYAPKG 150
Cdd:cd17356 59 FFGALISSFLSDRIGRKKSIQI-----GCVIYIIGAIIQVAAIGKWYQLIVG--RIIAGLGVGFASVLVPVYQSEVAPKH 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 151 KRGIISSLVAMGTNCGTLsaTAIWAVMFFALDREEliAWgWRVPFlasVVVMIFAIWLRMN---LKESPVFekvndaeti 227
Cdd:cd17356 132 IRGTLVSLYQLAITIGIL--VAYCINYGTHKLDGS--AQ-WRIPL---GLQIVWGLLLLIGmffLPESPRW--------- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 228 apvaAQDTSLGAMFKSksfwlatglrFGQA-GNSgliqtFLAGYLVQTLLFDKAIPTDALMISSILG---FLSIPLLGWL 303
Cdd:cd17356 195 ----LYRTILGIMLQL----------FQQLtGIN-----YFFYYGTTIFQSTGLTGSSPLLTSIILYivnFVSTIPGLFF 255
|
250
....*....|..
gi 556356000 304 SDKMGRRLPYIL 315
Cdd:cd17356 256 VDKFGRRTCLLI 267
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-166 |
2.77e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.12 E-value: 2.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 15 KAAVSGWLGTALEFMDFQLYSLGAALVFHEIFFPEQSAAMALILAMGtygagyIARIVGAFIFGRMGDRIGRKKVLFITI 94
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFG------LGGVLGALLAGRLADRFGRRRLLLIGL 280
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556356000 95 TMMGICTTLIGVLPTyaqigifaPVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCG 166
Cdd:COG2814 281 LLLALGLLLLALAGS--------LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
71-348 |
2.99e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.03 E-value: 2.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 71 IVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYaqigifaPVLLVTlRIIQGLGAGAEISGAGTMLAEYAPKG 150
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL-------YALLAS-RALLGIGVAGIMTLATALIGDYFEGE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 151 KRgiissLVAMGTNCGTLSATAIWAVMFFALdreeLIAWGWRVPFLA---SVVVMIFAIWLrmnlkespVFEKVNDAETi 227
Cdd:cd17473 121 ER-----AKMLGLQSAAMSLGGVVFLLLGGA----LAEIGWRAPFLVyllALPVLILVLLF--------LPEPARKSKS- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 228 apVAAQDTSLGAMFKSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKM 307
Cdd:cd17473 183 --AASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRL 260
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 556356000 308 GRRLpyiLLNISAIILAYPMLSIIVdkSYAPGVIMLSIIVI 348
Cdd:cd17473 261 GKRR---LLAIGFALMALGFLLLAL--ASGLWVVLLGAILA 296
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
67-218 |
3.78e-05 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 46.07 E-value: 3.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 67 YIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAqigifapvLLVTLRIIQGLGAGAEISGAGTMLAEY 146
Cdd:cd17438 44 YLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYG--------AFLFCRLISGFGIGGSLPIVFAYFSEF 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 147 APKGKRGIISSLVAMGTNCGTLSATAI-WAVMffaldreELIAWG-----------WRV-------PFLASVVVMIFaiw 207
Cdd:cd17438 116 LAREKRGEHLSWLCMFWMIGGLYASAMaWSII-------PHYGWGfsmgtnyhfhsWRVfviicalPCIASIIALKF--- 185
|
170
....*....|.
gi 556356000 208 lrmnLKESPVF 218
Cdd:cd17438 186 ----MPESPRF 192
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
67-177 |
4.12e-05 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 45.67 E-value: 4.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 67 YIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAqigifapvLLVTLRIIQGLGAGAEISGAGTMLAEY 146
Cdd:cd17440 44 YLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYG--------LFLFCRLLSGFGIGGAVPTVFSYFAEV 115
|
90 100 110
....*....|....*....|....*....|..
gi 556356000 147 APKGKRGIISSLVAMGTNCGTLSATAI-WAVM 177
Cdd:cd17440 116 LAREKRGEHLSWLCMFWMIGGIYASAMaWAII 147
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
67-218 |
4.40e-05 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 45.56 E-value: 4.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 67 YIARIVGAFIFGRMGDRIGRKKVLFITITMMGIcttlIGVLPTYAQ-IGIFapvllVTLRIIQGLGAGAEISGAGTMLAE 145
Cdd:cd17363 44 YLGMMVGAFVWGGLADKLGRKQCLLIALSVNGV----FAFLSSFVQgYGFF-----LFCRLLSGIGIGGSIPIVFSYFAE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 146 YAPKGKRGIISSLVAMGTNCGTLSATAI-WAVMffaldreELIAWG-----------WRVPFLASVVVMIFAIWLRMNLK 213
Cdd:cd17363 115 FLAREKRGEHLSWLCMFWMIGGLYASAMaWAII-------PHYGWGfsmgtayqfhsWRVFVIVCALPSVASVVALTFMP 187
|
....*
gi 556356000 214 ESPVF 218
Cdd:cd17363 188 ESPRF 192
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
81-325 |
5.95e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 45.26 E-value: 5.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 81 GDRIGRKKVLFITITMMGICTTLIGVLPTYAQigifapvlLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVA 160
Cdd:cd17503 55 ADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 161 MGTNCGTLSATAIWAVMffaldreeLIAWGWRVPFLASVVVMIFAIWLrmnlkespvfekvndaetiAPVAaqDTSLgam 240
Cdd:cd17503 127 LVILLAPAIGPTLGGWL--------TDNLSWRWIFYINLPIGILALLL-------------------APLL--DLRL--- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 241 FKSKSFWLAT-GLRFGQAGNSGLIqtFLAGYLVQTLL-FDKAIPTDALMISSILGFLSIPLLGWLSDKMGrrlPYILLNI 318
Cdd:cd17503 175 FKDRNFTLGLlLSFLLGLGLFGAM--FLLPLYLQNVLgYSAFESGLVLAPGGLASAILSPLVGRLLDKFG---PRLLLLA 249
|
....*..
gi 556356000 319 SAIILAY 325
Cdd:cd17503 250 GLLLLAL 256
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
47-427 |
8.36e-05 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 44.71 E-value: 8.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 47 FPEQSAAMALILAMGTYGAGYIARIVGAFIfgrmgDRIGRKKVLFITITMMGICTTLIGVLPTyaqigifAPVLLVTLRI 126
Cdd:cd17314 33 FGYSSSQIATAASLSNLGMLLTQPILGFIA-----DSFGPRPLMALAGIMVLAGYTYLSYVFN-------SFPLSYACFV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 127 IQGLGAGAEISGAGTMLAEYAPKgKRGIISSLVAMGTNCGTLSATAIWAVMFfaldreELIAWGWRVPFLASVVVMIFAI 206
Cdd:cd17314 101 FIGAGTGILYGSAVLVTTQYFPD-TKGLALGLPTTGYSLGLVLGSPLLRILW------VFYGLALVYTILGILAAIVLSV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 207 WLRMNLKESPVFEKVNDAetiapVAAQDTSLGAMFKSKSFWLATGLRFGQAGNSGLIQTFLAGYLVqtLLFDKAIPTDAL 286
Cdd:cd17314 174 VSLLGFKEPPDNQARLHV-----QKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVR--SLQLDAPSFVTK 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 287 MISSILGFLSI--PLLGWLSDKMGRRlpYILLNISAIILAYPMLSIIVDKSYAPgVIMLSIIVIHNFAVLGLFALENITM 364
Cdd:cd17314 247 LMSIYGLFNAFgrLLWGIVADFFGGR--LSTLSILLTILGLGLCAFLFLLKMTP-VGLVLTGSLLGFSYGGLFTVYPATV 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556356000 365 AEMFGSRNRFTRMAISKEAGGLVAVgFGPVLAGIFCNMTGSWwpIVVMLVAYSLIGLVSALLM 427
Cdd:cd17314 324 STVFGTESFATLYGILLFAPAIGSI-LGPMLGAKFYDRTPSY--ISAVYIYAVIVFLASAILL 383
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
21-346 |
1.16e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.14 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 21 WLGTALEFMDFQLYSLgaALVFHEIFFPEQSAAMALILAMGTygagyIARIVGAFIFGRMGDRIGRKKVLFITITMMGIC 100
Cdd:cd06173 5 WLAQLLSALGDWIFTV--ALPWLVLQLTGSALLVGLVLAAFF-----LPFLLFSPFAGVLADRFDRRRLLILADLLRALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 101 TTLIGVLPTYAQIGIfapVLLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMFfa 180
Cdd:cd06173 78 AAVLALLALLGSLSL---WLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV-- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 181 ldreelIAWGWRVPFLASVVVMIFAIWLRMNLKespvFEKVNDAETIAPVAAQDTSLGAMFKSKSFWLATGLRFGQAGN- 259
Cdd:cd06173 153 ------ALLGPGGAFAINALSFLLSALLLLFIR----RPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFAl 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 260 -SGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRLpyiLLNISAIILAYPMLSIIVDKSYAP 338
Cdd:cd06173 223 lGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR---LLLIGALLLGLALLVLGLSPSLWL 299
|
....*...
gi 556356000 339 GVIMLSII 346
Cdd:cd06173 300 LLAALFLL 307
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
76-168 |
1.36e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.79 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 76 IFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQigifapvlLVTLRIIQGLGAGAeISGAGTMLAEYAPKGKRGII 155
Cdd:cd17391 55 IWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQ--------LLILRLLQGVFSGY-VPNATALIASQTPKEKSGWA 125
|
90
....*....|...
gi 556356000 156 SSLVAMGTNCGTL 168
Cdd:cd17391 126 LGTLSTGVVAGTL 138
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
68-310 |
2.23e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 43.06 E-value: 2.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 68 IARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIG-VLPTYAQigifapvlLVTLRIIQGLgAGAEISGAGTMLAEY 146
Cdd:TIGR00886 48 LAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGlAVQSYSV--------LLLIRLFIGI-AGGSFASCMPWISFF 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 147 APKGKRGIISSLVAMGTNCGT----LSATAIWAVMFFALDREELIAWGWRVPFLASVVVMIFAIWLRMNLKESPvfekvn 222
Cdd:TIGR00886 119 FPKKIQGTALGLAAGWGNMGGgvaqFVMPPIIGSLIFGGGQPAHLAWGWAFVIVPAGILLLPALLIFFVGADTP------ 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 223 dAETIAPVAAQDTSLGAMFKSKSFWLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKaipTDALMISSILGFLSI---PL 299
Cdd:TIGR00886 193 -PGKPATGKLSFKEALKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLSK---VQAGAYASLGGFLGSlarPA 268
|
250
....*....|.
gi 556356000 300 LGWLSDKMGRR 310
Cdd:TIGR00886 269 GGAISDRLGGA 279
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
67-348 |
2.35e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 43.13 E-value: 2.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 67 YIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQigifapvlLVTLRIIQGLGAGAEISGAGTMLAEY 146
Cdd:TIGR00881 40 SIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWV--------MAALWALNGIFQGMGWPPCGRTVTKW 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 147 APKGKRGIISSLVAMGTNCGTLSATAIWAVMFfaldreeLIAWGWRVPF-LASVVVMIFA-IWLRMnLKESPVFEKVNDA 224
Cdd:TIGR00881 112 FSRSERGTWVSFWNCSHNVGGGLLPPLVLFGI-------AELYSWHWVFiVPGIIAIIVSlICFLL-LRDSPQSCGLPPA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 225 ETI---APVAAQDTSLGAMFKSKSF----------WLATGLRFGQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSI 291
Cdd:TIGR00881 184 EEMpneEPDGDAEKKEEELTKKQIFlqyvllnkvlWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYEL 263
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 556356000 292 LGFLSIPLLGWLSDKM--GRRLPYILLNISAIILAypMLSIIVDKSYAPGVIMLSIIVI 348
Cdd:TIGR00881 264 GGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVS--LLVYWLNPAANPLMDLICLFAL 320
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
254-441 |
2.76e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 2.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 254 FGQAGNSGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDKMGRRLPYILLNISAIILAYPMLSIivd 333
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA--- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 334 ksyAPGVIMLSIIVIHNFAVLGLFALENITMAEMFGSRNRFTRMAISkEAGGLVAVGFGPVLAGIFCNMTGSWWPIVVML 413
Cdd:pfam07690 83 ---SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLV-SAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180
....*....|....*....|....*...
gi 556356000 414 VAYSLIGLVSALLMPEVRDRDLSEAEDA 441
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEA 186
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
67-427 |
4.45e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 42.26 E-value: 4.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 67 YIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQIGifapVLLVTLRIIQGLGAgaeiSGAGTMLAEY 146
Cdd:cd17312 48 LIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFA----VLWGLNGLFQSMGW----PPCVKLLGNW 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 147 APKGKRGIISSLVAMGTNCGTLSATAIWAVMffaldreeLIAWGWRVPFL-ASVVVMIFAIWLRMNLKESPVFEKVndae 225
Cdd:cd17312 120 FSKKERGTVYGIWSTSHNFGGILAPILAASL--------ASYYGWRAAFLvPGIVGLVVAIILFFFLRDSPPYVWV---- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 226 tiapvaaqdTSLGAMFksksfwlATGLRFGqagnsglIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSD 305
Cdd:cd17312 188 ---------LSLAYAF-------VYIVRYA-------CLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSD 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 306 KM--GRRLPYILLNISAIILAYPMLSIIVDKSYAPGVIMLSIivihNFAVLGLFALENITMAEMFGSRNrftrmAISKEA 383
Cdd:cd17312 245 KLfgGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLI----GFFVGGPINLIGGAAAQDIGRKE-----AAGTAT 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 556356000 384 G-----GLVAVGFGPVLAGIFCNMTGSWWPIVVMLVAysliGLVSALLM 427
Cdd:cd17312 316 GfvglfGYLGASLAGLPLGYIIDHYGWSTVFYFLISA----ALLSVLLL 360
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
72-300 |
6.58e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 41.86 E-value: 6.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 72 VGAFI--FGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYaqigifapVLLVTLRIIQGLGAGAEISGAGTMLAEYAPK 149
Cdd:cd17476 46 VGTFIliFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNF--------IFFIICRALQGLGPAFLLPNAMALLGRTYPP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 150 GK-RGIISSLVAMGTN---------CGTLSATAIWAVMFFALDREE----LIAWGWRVPFLASVVVMIFAIWLRMNLKES 215
Cdd:cd17476 118 GPrKNIVFSLFGATAPlgfalggvfGGLFAQLAWWPWIFWFLAILAaivaVAAIFWTSPSFIAVLLAVFLGWASFGIWVF 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 216 PVFEKVNDAETIAPvaaqdtslgamfksksfwLATGLRFGQAGNSGLIQTFLAGYLVqtllfdKAIPTDALMISSILGFL 295
Cdd:cd17476 198 YATQYFQNVRGYSP------------------LLTSARFIPMAIGGVLAAITVGFLI------ARLPPSYIMAISMVAFL 253
|
....*
gi 556356000 296 SIPLL 300
Cdd:cd17476 254 VGPIL 258
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
68-212 |
8.38e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 41.48 E-value: 8.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 68 IARIVGAFIFGRMGDRIGRKKVLFITitmmGICTTLIGVLPTYAQigifAPVLLVTLRIIQGLGAGAEISGAGTMLAEYA 147
Cdd:cd17391 251 VSSLLSAPRLGKLGDRIGHHRILLGA----LLASALLYIPQAFVQ----TPWQLGILRFLLGLATGGLLPAINSLLAKIT 322
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556356000 148 PKGKRGIISSLVAMGTNCGTLSATAIWAVMffaldreeLIAWGWR-VPFLASVVVMIFAIWLRMNL 212
Cdd:cd17391 323 PKEVAGRIFGYNQSFQYLGNVAGPLLGSAI--------AAHFGYRaVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
68-177 |
9.22e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 9.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 68 IARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQIGIFApvllvtlrIIQGLGAGAEISGAGTMLAEYA 147
Cdd:cd17473 244 LAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGA--------ILAGLGFGLLLPTLNSWAMSLV 315
|
90 100 110
....*....|....*....|....*....|
gi 556356000 148 PKGKRGIISSLVAMGTNCGTLSATAIWAVM 177
Cdd:cd17473 316 PPELRGRAMGIVTSAFFLGQFLSPLVLGPL 345
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
72-195 |
1.16e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 41.02 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 72 VGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQIGIFapvllvtlRIIQGLGAGAEISGAGTMLAEYAPKGK 151
Cdd:cd17323 49 LGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIIL--------RFLQGFFGSSPLAIGAGTIADLFTPEE 120
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 556356000 152 RGIISSLVAMGTNCGTLSATAIWAVMFFaldreeliAWGWRVPF 195
Cdd:cd17323 121 RGKAMGVYSLGPLLGPALGPIIGGFITQ--------SLGWRWIF 156
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
78-210 |
1.30e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 41.00 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 78 GRMGDRIGRKKVLFITITMMGICTTLIgvlPTYAQIGIFApvlLVTLRIIQGLGAGAEISGAGTMLAEYAPKGKRGIISS 157
Cdd:cd17380 55 GYLADRFGGKKVLLLAVALWSLATLLT---PLLAYSSLPL---LILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVS 128
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 556356000 158 LVAMGTNCGTLSATAIWAVMffaldreeLIAWGWRVPFL--ASVVVMIFAIWLRM 210
Cdd:cd17380 129 IVTAGSYLGTLLGGLIGPLL--------LEYYGWPSVFYffGLLGLLWALVWLIY 175
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
58-427 |
2.01e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 40.25 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 58 LAMGTYGAGYIariVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQigifapvlLVTLRIIQGLGAGAEIS 137
Cdd:cd17320 38 LTLSAYLLGFA---LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--------LLIARFLQGLGAAAGSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 138 GAGTMLAEYAPKGKRGIISSLVAMGTNCGTLSATAIWAVMffaldreeLIAWGWRVPF-----LASVVVMIFAIWLRMNL 212
Cdd:cd17320 107 VARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLL--------LLFFGWRAIFvflalLGLLLLLLVLLFLPETL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 213 KEspvfekvndAETIAPVAAQDTSLGAMFKSKSFWLATglrFGQAGNSGLIQTFLAG--YLVQTLLFdkaIPTDALMISS 290
Cdd:cd17320 179 PE---------EKRKPLLSSLLRAYKRVLKNRRFLGYA---LALGLSFAGLFAYLAAapFIYIEQLG---LSPAQFGLLF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 291 ILGFLSIPLLGWLSDKMGRRL-PYILLNISAIILAYPMLSIIVdksyapgviMLSIIVIHNFAVLGLFALENITMAEMFG 369
Cdd:cd17320 244 ALNAIALILGSLLNGRLVRRFgPRRLLRLGLLLLLAAALVLLL---------AALLGGLSLWPLVAPLFLIFFGFGLIFP 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556356000 370 SRNRFTRMAISKEAGGLVAV-GFGPVLAGIFCNMTGSWWP---IVVMLVAYSLIGLVSALLM 427
Cdd:cd17320 315 NATSLALEPFPHVAGTASALlGFLQFLIGALAGALVGLLPngtALPMGLLILVLGLLALLLL 376
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
64-173 |
2.80e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.87 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 64 GAGYIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAqigifapvLLVTLRIIQGLGAGAeISGAGTML 143
Cdd:cd17330 41 SSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLW--------LLFLARFLDGLTGGN-VSVAQAYI 111
|
90 100 110
....*....|....*....|....*....|
gi 556356000 144 AEYAPKGKRGIISSLVAMGTNCGTLSATAI 173
Cdd:cd17330 112 ADITDEEERAKAFGIISAAFGLGFILGPAL 141
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
71-173 |
2.81e-03 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 39.64 E-value: 2.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 71 IVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQIGIFapvllvtlRIIQGLGAGAEISGAGTMLAEYAPKG 150
Cdd:cd17379 47 LIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIF--------RFLQGLFGKGGWMTGYVLVTEFVGSK 118
|
90 100
....*....|....*....|...
gi 556356000 151 KRGIISSLVAMGTNCGTLSATAI 173
Cdd:cd17379 119 YRRTVGIVYQMFFTLGLLILPGI 141
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
60-166 |
3.79e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 39.47 E-value: 3.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 60 MGTYGAGY-IARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQigifapvlLVTLRIIQGLGAGAEISG 138
Cdd:cd17502 32 VSWVGTAYlLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTM--------LIVGRAIQGIGGGGLMSL 103
|
90 100 110
....*....|....*....|....*....|..
gi 556356000 139 AGTMLAEYAPKGKR----GIISSLVAMGTNCG 166
Cdd:cd17502 104 AFIIIADLVPPRERgkyqGYIGAVFGIASVAG 135
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
71-427 |
5.39e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 38.83 E-value: 5.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 71 IVGAFIfGRMGDRIGRKK-VLFITITMMGICTTLIGVLPTYAQIGIFApVLLVTLRIIQGLGAGAEISgAGTMLAEYAPK 149
Cdd:pfam13347 52 IVGHII-DRTRTRWGRRRpWLLLSAIILAVSFILLFTPPELGRAPLFI-WLLATYILLRIAYTFFEIP-YWSLGPELTRD 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 150 GK-RGIISSLVAMGTNCGTLSATAIWAVMFFALDREELIAWGWRVPFLASVVVMIFAIWLRMN-LKESPVFEKVNDAETI 227
Cdd:pfam13347 129 YDeRTSLTSYRSFFSVGGGLLAAALAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIITAAgTKERVSMRSKEDTGQK 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 228 APVAAQDtSLGAMFKSKSF-WLATGLRFGQAGnsGLIQTFLAGYLVQTLLFDKAIPTDALMISSILGFLSIPLLGWLSDK 306
Cdd:pfam13347 209 EAGSLLD-MLKEVFRNRAFlILLASFLLAALA--MGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKR 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 307 MGRRLPYILLNISAIILAypMLSIIVDKSYAPGVIMLSIIVihNFAVLGLFALENITMAEMF-------GSRNRFTRMA- 378
Cdd:pfam13347 286 IGKKNTYILGALITIAGF--ALALLLGPNNTLLFLVLYIII--GFGYGSSFFLPWSMLADVVdygelrtGKRREGTFFAm 361
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 556356000 379 ---ISKEAGGLVAVGFGPVLAGIFCNMTGSWWPIVV---MLVAYSLIGLVSALLM 427
Cdd:pfam13347 362 wsfISKLATGVGLGVSGLLLSAFGYNAGDSVQSPQAvtaIRLLYAVLPAVLFLVA 416
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
68-221 |
5.92e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 38.90 E-value: 5.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 68 IARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAqigifapvLLVTLRIIQGLGAGAEISGAGTMLAEYA 147
Cdd:TIGR00711 48 LANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLE--------LMIIFRVIQGFGGGPLIPLSFSTLLNIY 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 148 PKGKRGIISSLVAMGTNCG-----TLSATAIwavmffaldreELIAWGW----RVPFLASVVVMIFAIWLRMNLKESPVF 218
Cdd:TIGR00711 120 PPEKRGRAMAIWGLTVLVApalgpTLGGWII-----------ENYHWRWifliNVPIGIIVVVVAFFILPRDKPAASENF 188
|
...
gi 556356000 219 EKV 221
Cdd:TIGR00711 189 DFL 191
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
67-332 |
7.00e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 38.77 E-value: 7.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 67 YIARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYAQigifapvlLVTLRIIQGLGAGAEISGAGTMLAEY 146
Cdd:cd17327 51 YVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGG--------LIALRFFLGLFESGVFPGFILYLGMW 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 147 APK---GKR-----------GIISSLVAMG----TNCGTLSAtaiWAVMFfaldreelIAWGwrvpFLASVVVMIFAIWL 208
Cdd:cd17327 123 YKReeqAKRiaffyaaaglgSIFGGLLAYGvfkiLGVGGLAG---WRWLF--------IIEG----LITIIIGLVIFFWL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 209 RMNLKESPVFEKVNDAETIAPVAAQDTSLGAM----------FKSKSFWLATGLRFGQAGNSGLIQTFLagyLVQTLLFD 278
Cdd:cd17327 188 PDNPSKAWFLTEEEKELAVERLRANQTGKGDQkfkwkqikeaFKDPRTWLLFLFFFCSQITNNGISNFL---PLILKSLG 264
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 556356000 279 KAIPTDALM--ISSILGFLSIPLLGWLSDKMGRRLPYIllnISAIILAYPMLSIIV 332
Cdd:cd17327 265 FYSLQTNLLsvPIGALGAVSLLIAALLSDRFKKRGLFA---IFACVLALVGSIILL 317
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
72-180 |
7.37e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.33 E-value: 7.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 72 VGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYaqigifaPVLLVtLRIIQGLGaGAEISGAGTMLAEYAPKGK 151
Cdd:cd17504 46 VSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNL-------PVLIA-GRALQGIG-GAVFPLAFALVREEFPPER 116
|
90 100 110
....*....|....*....|....*....|....*...
gi 556356000 152 R----GIISSLVAMGTNCGTLSATAI-----WAVMFFA 180
Cdd:cd17504 117 VpvaqGILSATFGIGAGIGLPLGGWIvqhlgWRWIFWT 154
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
47-168 |
8.41e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 38.57 E-value: 8.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 47 FPEQSAAMALILAMGTYGAgyiarIVGAFIFGRMGDRIGRKKVLFITitmMGICTTLIGVLPTYAQIGIfapVLLVTLRI 126
Cdd:TIGR00894 71 FKWSGALQGLILSSHFYGQ-----IIIQIPVGYLAGKYVFKWSIGIG---MFLSSVISIVIPWAAGGGI---ALVVFCRV 139
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 556356000 127 IQGLGAGAEISGAGTMLAEYAPKGKRGIISSLVAMGTNCGTL 168
Cdd:TIGR00894 140 IQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTF 181
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
68-168 |
9.10e-03 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 38.15 E-value: 9.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556356000 68 IARIVGAFIFGRMGDRIGRKKVLFITITMMGICTTLIGVLPTYaqigifaPVLLVTlRIIQGLGAGAEISGAGTMLAEYA 147
Cdd:cd17437 43 IISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNY-------PVLMVG-RFVAGIGVGFALMIAPVYTAEVA 114
|
90 100
....*....|....*....|.
gi 556356000 148 PKGKRGIISSLVAMGTNCGTL 168
Cdd:cd17437 115 PASSRGFLTSFPEIFINIGIL 135
|
|
| |
