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Conserved domains on  [gi|556407299|ref|WP_023305384|]
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MULTISPECIES: AraC family transcriptional regulator [Enterobacter]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11454391)

helix-turn-helix (HTH) domain-containing protein with an AraC family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.60
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  10473770|15808743|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
244-314 4.96e-23

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 90.69  E-value: 4.96e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556407299   244 MSPSSLRSKFRQRYGCTLFDYLRDCRLALARRYLLEGH-SVQQAAWMCGYQHATNFATAFRRHYGISPGDVR 314
Cdd:smart00342  13 VSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDlSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEYR 84
QdoI super family cl43562
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
68-133 1.24e-03

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


The actual alignment was detected with superfamily member COG1917:

Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 37.52  E-value: 1.24e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556407299  68 LQPYETTSRHSSPLY-MLVVLEGCVTLTLNGIDYPVRPGMAFssRLSEDQVMSARHDADSTLKTLSF 133
Cdd:COG1917   30 FEPGARTPWHSHPGEeLIYVLEGEGEVEVGGEEYELKPGDVV--FIPPGVPHAFRNLGDEPAVLLVV 94
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
244-314 4.96e-23

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 90.69  E-value: 4.96e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556407299   244 MSPSSLRSKFRQRYGCTLFDYLRDCRLALARRYLLEGH-SVQQAAWMCGYQHATNFATAFRRHYGISPGDVR 314
Cdd:smart00342  13 VSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDlSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEYR 84
HTH_18 pfam12833
Helix-turn-helix domain;
244-315 1.24e-22

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 89.57  E-value: 1.24e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556407299  244 MSPSSLRSKFRQRYGCTLFDYLRDCRLALARRYLLE--GHSVQQAAWMCGYQHATNFATAFRRHYGISPGDVRK 315
Cdd:pfam12833   7 MSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
244-315 8.93e-19

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 84.06  E-value: 8.93e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556407299 244 MSPSSLRSKFRQRYGCTLFDYLRDCRLALARRYLLEG-HSVQQAAWMCGYQHATNFATAFRRHYGISPGDVRK 315
Cdd:COG2207  180 LSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRK 252
ftrA PRK09393
transcriptional activator FtrA; Provisional
 208-315 2.68e-08

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 54.20  E-value: 2.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556407299 208 PCPSRpEHARLERVRCLLEQSPECDHTLAQLAALAAMSPSSLRSKFRQRYGCTLFDYLRDCRLALARRYL-LEGHSVQQA 286
Cdd:PRK09393 211 PVASR-ESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLeSSALSIDQI 289

                         90       100
                 ....*....|....*....|....*....
gi 556407299 287 AWMCGYQHATNFATAFRRHYGISPGDVRK 315
Cdd:PRK09393 290 AERAGFGSEESLRHHFRRRAATSPAAYRK 318
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
68-133 1.24e-03

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 37.52  E-value: 1.24e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556407299  68 LQPYETTSRHSSPLY-MLVVLEGCVTLTLNGIDYPVRPGMAFssRLSEDQVMSARHDADSTLKTLSF 133
Cdd:COG1917   30 FEPGARTPWHSHPGEeLIYVLEGEGEVEVGGEEYELKPGDVV--FIPPGVPHAFRNLGDEPAVLLVV 94
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
244-314 4.96e-23

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 90.69  E-value: 4.96e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556407299   244 MSPSSLRSKFRQRYGCTLFDYLRDCRLALARRYLLEGH-SVQQAAWMCGYQHATNFATAFRRHYGISPGDVR 314
Cdd:smart00342  13 VSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDlSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEYR 84
HTH_18 pfam12833
Helix-turn-helix domain;
244-315 1.24e-22

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 89.57  E-value: 1.24e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556407299  244 MSPSSLRSKFRQRYGCTLFDYLRDCRLALARRYLLE--GHSVQQAAWMCGYQHATNFATAFRRHYGISPGDVRK 315
Cdd:pfam12833   7 MSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
244-315 8.93e-19

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 84.06  E-value: 8.93e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556407299 244 MSPSSLRSKFRQRYGCTLFDYLRDCRLALARRYLLEG-HSVQQAAWMCGYQHATNFATAFRRHYGISPGDVRK 315
Cdd:COG2207  180 LSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRK 252
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 210-315 1.80e-15

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 75.58  E-value: 1.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556407299 210 PSRPEHARLERVRCLLEQSPECDHTLAQLAALAAMSPSSLRSKFRQRYGCTLFDYLRDCRLALARRyLLE--GHSVQQAA 287
Cdd:COG4977  204 PLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARR-LLEttDLSIEEIA 282

                         90       100
                 ....*....|....*....|....*...
gi 556407299 288 WMCGYQHATNFATAFRRHYGISPGDVRK 315
Cdd:COG4977  283 AACGFGSASHFRRAFRRRFGVSPSAYRR 310
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 210-317 3.13e-10

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 60.45  E-value: 3.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556407299 210 PSRPEHARL-ERVRCLLEQSPECDHTLAQLAALAAMSPSSLRSKFRQRYGCTLFDYLRDCRLALARRYLLEGHSVQQAAW 288
Cdd:COG2169   77 PGSPPRADLvARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLSVTDAAY 156

                         90       100
                 ....*....|....*....|....*....
gi 556407299 289 MCGYQHATNFATAFRRHYGISPGDVRKLR 317
Cdd:COG2169  157 AAGFGSLSRFYEAFKKLLGMTPSAYRRGG 185
ftrA PRK09393
transcriptional activator FtrA; Provisional
 208-315 2.68e-08

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 54.20  E-value: 2.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556407299 208 PCPSRpEHARLERVRCLLEQSPECDHTLAQLAALAAMSPSSLRSKFRQRYGCTLFDYLRDCRLALARRYL-LEGHSVQQA 286
Cdd:PRK09393 211 PVASR-ESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLeSSALSIDQI 289

                         90       100
                 ....*....|....*....|....*....
gi 556407299 287 AWMCGYQHATNFATAFRRHYGISPGDVRK 315
Cdd:PRK09393 290 AERAGFGSEESLRHHFRRRAATSPAAYRK 318
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 244-310 1.47e-07

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 51.85  E-value: 1.47e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556407299 244 MSPSSLRSKFRQRyGCTLFDYLRDCRLALARRYL-LEGHSVQQAAWMCGYQHATNFATAFRRHYGISP 310
Cdd:PRK09978 170 MSPSLLKKKLREE-ETSYSQLLTECRMQRALQLIvIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTP 236
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
187-316 1.72e-07

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 51.59  E-value: 1.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556407299 187 KLLLEGLMYQLLGHGLNQCQLPCPSRpeHARLERVRCLLEQSPECDHTLAQLAALAAMSPSSLRSKFRQRYGCTLFDYLR 266
Cdd:PRK13502 149 ELLFGQLVMTLKRHRYATDDLPATSR--ETLLDKLITALANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLR 226

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 556407299 267 DCRLALArRYLLEgHS---VQQAAWMCGYQHATNFATAFRRHYGISPGDVRKL 316
Cdd:PRK13502 227 QVRICHA-QYLLQ-HSplmISEISMQCGFEDSNYFSVVFTRETGMTPSQWRHL 277
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
248-317 8.61e-06

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 46.59  E-value: 8.61e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556407299 248 SLRSKFRQ---RYGCTLFDYLRDCRLALARRYLLEG-HSVQQAAWMCGYQHATNFATAFRRHYGISPGDVRKLR 317
Cdd:PRK13503 200 SLRTLHRQlkqQTGLTPQRYLNRLRLLKARHLLRHSdASVTDIAYRCGFGDSNHFSTLFRREFSWSPRDIRQGR 273
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
244-315 1.33e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 46.05  E-value: 1.33e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556407299 244 MSPSSLRSKFRQRYGCTLFDYLRDCRLALArRYLLEG--HSVQQAAWMCGYQHATNFATAFRRHYGISPGDVRK 315
Cdd:PRK13501 204 LVERSLKQLFRQQTGMSISHYLRQIRLCHA-KCLLRGseHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQ 276
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
245-316 6.69e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 43.94  E-value: 6.69e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556407299 245 SPSSLRSKFRQRYGCTLFDYLRDCRLALArRYLLEgHS---VQQAAWMCGYQHATNFATAFRRHYGISPGDVRKL 316
Cdd:PRK13500 235 SERVLRQQFRQQTGMTINQYLRQVRVCHA-QYLLQ-HSrllISDISTECGFEDSNYFSVVFTRETGMTPSQWRHL 307
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 244-315 8.29e-05

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 43.54  E-value: 8.29e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556407299 244 MSPSSLRSKFRQRYgCTLFDYLRDCRLALARRYLLEGHSVQQAAWMCGYQHATNFATAFRRHYGISPGDVRK 315
Cdd:PRK09940 162 ISESLLKKKLKQEQ-TTFSQILLDARMQHAKNLIRVEGSVNKIAEQCGYASTSYFIYAFRKHFGNSPKRVSK 232
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 219-310 1.40e-04

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 43.06  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556407299 219 ERVRCLLEQSPECDHTLAQLAALAAMSPSSLRSKFRQRyGCTLFDYLRDCRLALARRYLLEG-HSVQQAAWMCGYQHATN 297
Cdd:PRK15185 209 ERVYNIISSSPSRQWKLTDVADHIFMSTSTLKRKLAEE-GTSFSDIYLSARMNQAAKLLRIGnHNVNAVALKCGYDSTSY 287

                         90
                 ....*....|...
gi 556407299 298 FATAFRRHYGISP 310
Cdd:PRK15185 288 FIQCFKKYFKTTP 300
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 244-312 5.24e-04

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 41.20  E-value: 5.24e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556407299 244 MSPSSLRSKFRQRYGCTLFDYLrDCRLALARRYLLEG-HSVQQAAWMCGYQHATNFATAFRRHYGISPGD 312
Cdd:PRK15186 209 MSCSTLKRKLKQENTSFSEVYL-NARMNKATKLLRNSeYNITRVAYMCGYDSASYFTCVFKKHFKTTPSE 277
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
244-317 9.11e-04

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 40.34  E-value: 9.11e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556407299 244 MSPSSLRSKFRQRYGCTLFDYLRDCRLALARRYLL-EGHSVQQAAWMCGYQHATNFATAFRRHYGISPGDVRKLR 317
Cdd:PRK10572 211 LSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQtTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFRARC 285
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
68-133 1.24e-03

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 37.52  E-value: 1.24e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556407299  68 LQPYETTSRHSSPLY-MLVVLEGCVTLTLNGIDYPVRPGMAFssRLSEDQVMSARHDADSTLKTLSF 133
Cdd:COG1917   30 FEPGARTPWHSHPGEeLIYVLEGEGEVEVGGEEYELKPGDVV--FIPPGVPHAFRNLGDEPAVLLVV 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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