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Conserved domains on  [gi|556411779|ref|WP_023306126|]
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MULTISPECIES: pyrroloquinoline quinone-dependent dehydrogenase [Enterobacter]

Protein Classification

pyrroloquinoline quinone-dependent dehydrogenase( domain architecture ID 10178902)

pyrroloquinoline quinone-dependent glucose dehydrogenase converts D-glucose to D-glucono-1,5-lactone or related enzyme

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PQQ_mGDH cd10280
Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes ...
 89-696 0e+00

Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes belongs to the dehydrogenase family with pyrroloquinoline quinone (PQQ) as cofactor, and is the only subfamily that is bound to the membrane. Glucose dehydrogenase converts D-glucose to D-glucono-1,5-lactone in a reaction that is coupled with the respiratory chain in the periplasmic oxidation of sugars and alcohols in gram-negative bacteria. Ubiquinone functions as the electron acceptor. The alignment model contains an 8-bladed beta-propeller.


:

Pssm-ID: 199838 [Multi-domain]  Cd Length: 616  Bit Score: 764.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  89 WDSFHGQLNAQKYSPLTQITADNVNKLTKVWEFHTGDVsdGKGDTPATVWSATPIFANDTLYIGTPFDRLIALDPGTGKE 168
Cdd:cd10280    1 WPAYGGDPGGTRYSPLDQITPDNVGKLKVAWTYHTGDL--PGPDGNEGTFEATPLKVGGTLYLCTPHNRVIALDAATGKE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 169 KWHYDTKSSRKALTQPvLKNRGVSYWQAKNPVKgeACQKMVYMGTVDGKLFALDADSGKPCSGFADNGVLDLNQWNTVNA 248
Cdd:cd10280   79 LWRFDPKAGADAAPGH-QTCRGVSYWEDGAAAA--ACARRIFFGTGDARLIALDARTGKPCPDFGDNGVVDLREGLGRVK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 249 KYPLSVLQPPTVVGNHLLVGWAGKDWAYAEAPPGTVFSVNAQTGKLEWTFEAIPAEI---------RKRTGTANVWTHMS 319
Cdd:cd10280  156 PGFYSSTSPPTVYGDLVIVGSAVADNQAVDAPSGVIRAFDVRTGKLVWAFDTIPPPGeagpdtagaWYTRGGPNVWAGMS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 320 ADEANGLVYLPVSSPSPNYWGGNRVDAIPLGTSTTALDINTGKVVWSRQWVHHDVWDYDINSAPTLMDITVDGKQIPALV 399
Cdd:cd10280  236 ADEKLGLVYLPTGSATPDFYGGDRPGDNLFANSLVALDAATGKRRWHFQTVHHDLWDYDLPAQPTLVDVPRDGKTVPAVA 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 400 QATKQGFLFVVNRLTGEDVWPIEERPVPQGDgsVQGEVLSPTQPFPTKPAPLLDQSKKPEIWKLADIVGGGQCSRLWDNL 479
Cdd:cd10280  316 QPTKQGFVFVLDRRTGKPLWPVEERPVPQGD--VPGERTSPTQPFPTLPPPFARQGLTEDDMWGATPFDQLACRIQFRSL 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 480 TYEGMYTPPTTKgeGTLTYPDSAGGVQWGGVAFDPQKQIAIVNTSHIVQYVKLYSREDYDNADKDSGNESGF-----APQ 554
Cdd:cd10280  394 RYEGLFTPPSLD--GTLIFPGNDGGANWGGAAVDPERGILYVNSNRLPFVIQLVPRAPGDPAGVAGGGEGGGggggpSPQ 471

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 555 EGAPYGMRLLVASNWLGMPCWQPPFGEIVAIDMHTGDVKWRRPVGASQQYGFF---MPESWGSPTIGGPAVTAGGVIFIG 631
Cdd:cd10280  472 AGTPYGVGRGRFLSPLGLPCQAPPWGTLTAIDLNTGKILWQVPLGTVPDLGPKgipLPIPTGTPNLGGPVVTAGGLVFIA 551

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556411779 632 ASMDAKVRAYSVESGEELWSDQAEAPAVANPSVYEYKGRQYVAFVAGGNTILKDQVGDQVVVYAL 696
Cdd:cd10280  552 ATQDNYLRAFDKATGKELWEARLPAGGQATPMTYEVDGKQYVVIAAGGHGSLGTKRGDSVIAYAL 616
 
Name Accession Description Interval E-value
PQQ_mGDH cd10280
Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes ...
 89-696 0e+00

Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes belongs to the dehydrogenase family with pyrroloquinoline quinone (PQQ) as cofactor, and is the only subfamily that is bound to the membrane. Glucose dehydrogenase converts D-glucose to D-glucono-1,5-lactone in a reaction that is coupled with the respiratory chain in the periplasmic oxidation of sugars and alcohols in gram-negative bacteria. Ubiquinone functions as the electron acceptor. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199838 [Multi-domain]  Cd Length: 616  Bit Score: 764.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  89 WDSFHGQLNAQKYSPLTQITADNVNKLTKVWEFHTGDVsdGKGDTPATVWSATPIFANDTLYIGTPFDRLIALDPGTGKE 168
Cdd:cd10280    1 WPAYGGDPGGTRYSPLDQITPDNVGKLKVAWTYHTGDL--PGPDGNEGTFEATPLKVGGTLYLCTPHNRVIALDAATGKE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 169 KWHYDTKSSRKALTQPvLKNRGVSYWQAKNPVKgeACQKMVYMGTVDGKLFALDADSGKPCSGFADNGVLDLNQWNTVNA 248
Cdd:cd10280   79 LWRFDPKAGADAAPGH-QTCRGVSYWEDGAAAA--ACARRIFFGTGDARLIALDARTGKPCPDFGDNGVVDLREGLGRVK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 249 KYPLSVLQPPTVVGNHLLVGWAGKDWAYAEAPPGTVFSVNAQTGKLEWTFEAIPAEI---------RKRTGTANVWTHMS 319
Cdd:cd10280  156 PGFYSSTSPPTVYGDLVIVGSAVADNQAVDAPSGVIRAFDVRTGKLVWAFDTIPPPGeagpdtagaWYTRGGPNVWAGMS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 320 ADEANGLVYLPVSSPSPNYWGGNRVDAIPLGTSTTALDINTGKVVWSRQWVHHDVWDYDINSAPTLMDITVDGKQIPALV 399
Cdd:cd10280  236 ADEKLGLVYLPTGSATPDFYGGDRPGDNLFANSLVALDAATGKRRWHFQTVHHDLWDYDLPAQPTLVDVPRDGKTVPAVA 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 400 QATKQGFLFVVNRLTGEDVWPIEERPVPQGDgsVQGEVLSPTQPFPTKPAPLLDQSKKPEIWKLADIVGGGQCSRLWDNL 479
Cdd:cd10280  316 QPTKQGFVFVLDRRTGKPLWPVEERPVPQGD--VPGERTSPTQPFPTLPPPFARQGLTEDDMWGATPFDQLACRIQFRSL 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 480 TYEGMYTPPTTKgeGTLTYPDSAGGVQWGGVAFDPQKQIAIVNTSHIVQYVKLYSREDYDNADKDSGNESGF-----APQ 554
Cdd:cd10280  394 RYEGLFTPPSLD--GTLIFPGNDGGANWGGAAVDPERGILYVNSNRLPFVIQLVPRAPGDPAGVAGGGEGGGggggpSPQ 471

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 555 EGAPYGMRLLVASNWLGMPCWQPPFGEIVAIDMHTGDVKWRRPVGASQQYGFF---MPESWGSPTIGGPAVTAGGVIFIG 631
Cdd:cd10280  472 AGTPYGVGRGRFLSPLGLPCQAPPWGTLTAIDLNTGKILWQVPLGTVPDLGPKgipLPIPTGTPNLGGPVVTAGGLVFIA 551

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556411779 632 ASMDAKVRAYSVESGEELWSDQAEAPAVANPSVYEYKGRQYVAFVAGGNTILKDQVGDQVVVYAL 696
Cdd:cd10280  552 ATQDNYLRAFDKATGKELWEARLPAGGQATPMTYEVDGKQYVVIAAGGHGSLGTKRGDSVIAYAL 616
PQQ_membr_DH TIGR03074
membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; This protein ...
 66-697 0e+00

membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Members of this family have several predicted transmembrane helices in the N-terminal region, and include the quinoprotein glucose dehydrogenase (EC 1.1.5.2) of Escherichia coli and the quinate/shikimate dehydrogenase of Acinetobacter sp. ADP1 (EC 1.1.99.25). Sequences closely related except for the absense of the N-terminal hydrophobic region, scoring in the gray zone between the trusted and noise cutoffs, include PQQ-dependent glycerol (EC 1.1.99.22) and and other polyol (sugar alcohol) dehydrogenases.


Pssm-ID: 274418 [Multi-domain]  Cd Length: 764  Bit Score: 535.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779   66 SGDGKKVASASQPATPLVPGTpTWDSFHGQLNAQKYSPLTQITADNVNKLTKVWEFHTGDVSDGKGDTPATvWSATPIFA 145
Cdd:TIGR03074 116 VGALDTEVPATAAAAPAVPAG-DWAAYGRTQAGQRYSPLDQINPDNVGNLKVAWTYHTGDLKTPDDPGEAT-FQATPLKV 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  146 NDTLYIGTPFDRLIALDPGTGKEKWHYDTKSSRKALTQpVLKNRGVSYWQAKNPVKGEA-------CQKMVYMGTVDGKL 218
Cdd:TIGR03074 194 GDTLYLCTPHNKVIALDAATGKEKWKFDPKLKTEADRQ-HQTCRGVSYYDAPAAAAGPAgpaapadCARRIILPTSDARL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  219 FALDADSGKPCSGFADNGVLDLNQwNTVNAK----YPLSvlqPPTVVGNHLLVGWAGKDWAYAEAPPGTVFSVNAQTGKL 294
Cdd:TIGR03074 273 IALDADTGKLCEDFGNNGTVDLTA-GMGPTPpgyyYPTS---PPLVAGTTVVIGGRVADNYSTDEPSGVIRAFDVNTGAL 348

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  295 EWTFE-------AIPAEIRKRT-GTANVWTHMSADEANGLVYLPVSSPSPNYWGGNRV-DAIPLGTSTTALDINTGKVVW 365
Cdd:TIGR03074 349 VWAWDpgnpdptAPPAPGETYTrNSPNSWSVASYDEKLGLVYLPMGNQTPDQWGGDRTpADEKYSSSLVALDATTGKERW 428

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  366 SRQWVHHDVWDYDINSAPTLMDITV-DGKQIPALVQATKQGFLFVVNRLTGEDVWPIEERPVPQGDgsVQGEVLSPTQPF 444
Cdd:TIGR03074 429 VFQTVHHDLWDMDVPAQPSLVDLPKaDGTTVPALVAPTKQGQIYVLDRRTGEPIVPVEEVPVPQGA--VPGERYSPTQPF 506

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  445 --PTKPAPLLDQSkkpEIW------KLAdivgggqCSRLWDNLTYEGMYTPPTTkgEGTLTYPDSAGGVQWGGVAFDPQK 516
Cdd:TIGR03074 507 svLTFGPPTLTES---DMWgatpfdQLA-------CRIQFKSLRYEGLYTPPSE--QGSLVFPGNLGGFNWGGVAVDPTR 574

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  517 QIAIVNTSHIVQYVKLYSREDYDNADKD---SGNESGFAPQEGAPYGMRLLVASNWLGMPCWQPPFGEIVAIDMHTGDVK 593
Cdd:TIGR03074 575 QVMFVNPMRLPFVSQLVPRAPGDEAPSGakgKGTEMGLNPNKGTPYAVNMNPFLSPLGIPCQAPPWGYMAAIDLKTGKVV 654

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  594 WRRPVGASQQYGFF-----MPESWGSPTIGGPAVTAGGVIFIGASMDAKVRAYSVESGEELWsdQAEAPA--VANPSVY- 665
Cdd:TIGR03074 655 WQHPNGTVRDTGPMgipmpLPIPIGVPTLGGPLATAGGLVFIGATQDNYLRAYDLSTGKELW--EARLPAggQATPMTYm 732

                         650       660       670
                  ....*....|....*....|....*....|..
gi 556411779  666 EYKGRQYVAFVAGGNTILKDQVGDQVVVYALP 697
Cdd:TIGR03074 733 GKDGKQYVVIVAGGHGSSGTKRGDYVIAYALP 764
Gcd COG4993
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
89-697 0e+00

Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];


Pssm-ID: 444017 [Multi-domain]  Cd Length: 515  Bit Score: 527.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  89 WDSFHGQLNAQKYSPLTQITADNVNKLTKVWEFHTGDVsdgkgdtPATVWSATPIFANDTLYIGTPFDRLIALDPGTGKE 168
Cdd:COG4993    5 WLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGDL-------PERGHEATPLVVDGVLYVCTPHNRVFALDAATGKE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 169 KWHYDTKSSRKALTQPVlKNRGVSYWQAKnpvkgeacqkmVYMGTVDGKLFALDADSGKPCsgfadngvldlnqWNTVNA 248
Cdd:COG4993   78 LWRYDPKLPDDAACCDV-VNRGVAYYDGR-----------IFLGTLDGRLVALDAKTGKVC-------------WDVKVG 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 249 KYPL--SVLQPPTVVGNHLLVGWAGKDWAyaeaPPGTVFSVNAQTGKLEWTFEAIP-----------AEIRKRTGTANVW 315
Cdd:COG4993  133 DPKKgyTITSAPLVVKDKVIVGGSGGEFG----PRGVVRAYDARTGKLVWRFDTIPdpgepgaetwpPGDTWKRGGGNVW 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 316 THMSADEANGLVYLPVSSPSPNYWGGNRVDAIPLGTSTTALDINTGKVVWSRQWVHHDVWDYDINSAPTLMDITVDGKQI 395
Cdd:COG4993  209 GTMSYDPELGLVYLPTGNPAPDWNGGQRPGDNLYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDLPVDGKTR 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 396 PALVQATKQGFLFVVNRLTGEDVWpieerpvpqgdgsvqgevlspTQPFpTKPAPLldqSKKPEIWKLADIvgggqcsrl 475
Cdd:COG4993  289 KALVQATKNGFIYVLDRETGEPLV---------------------TQPF-VKPPNW---ATEIDMWGATPI--------- 334

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 476 wdnltyegmYTPPTTKGEGTLTYPDSAGGVQWGGVAFDPQKQIAIVNTSHIVQYVKLYSREdydnadkdsgnesgfaPQE 555
Cdd:COG4993  335 ---------QTPPSLDGKTTLICPGALGGKNWGPAAYDPETGLLYVPANELCMDYELVPRE----------------YQA 389

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 556 GAPY-GMRLLVasnwlgMPCWQPPFGEIVAIDMHTGDVKWRRPVGAsqqygffmpeswgsPTIGGPAVTAGGVIFIGAsM 634
Cdd:COG4993  390 GAPYlGATLTM------YPCPAPPWGTLTAIDLNTGKIVWQVPLGF--------------PNWGGPLATAGGLVFIGT-L 448

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556411779 635 DAKVRAYSVESGEELWSDQAEAPAVANPSVYEYKGRQYVAFVAGGNT----ILKDQVGDQVVVYALP 697
Cdd:COG4993  449 DGYLRAFDAKTGKELWKFRLPSGGQATPMTYEVDGKQYVAVAAGGGGwlglGLYTPQGDYLIAFALP 515
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 124-419 1.68e-15

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 76.29  E-value: 1.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  124 GDVSDGKGDTPATVWSAT--------PIFANDTLYIGTPFDRLIALDPGTGKEKWhydtkssRKALTQPVLKNRGVSywq 195
Cdd:pfam13360   3 GVVTALDAATGAELWRVDletglgggVAVDGGRLFVATGGGQLVALDAATGKLLW-------RQTLSGEVLGAPLVA--- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  196 aknpvkgeacQKMVYMGTVDGKLFALDADSGKPcsgfadngvldlnQWNTVNAKYPLSVLQP--PTVVGNHLLVGWAGkd 273
Cdd:pfam13360  73 ----------GGRVFVVAGDGSLIALDAADGRR-------------LWSYQRSGEPLALRSSgsPAVVGDTVVAGFSS-- 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  274 wayaeappGTVFSVNAQTGKLEWTfeaipAEIRKRTGTANVWthmsadEANGLVYLPVSSpspnywgGNRVDAIPLGTST 353
Cdd:pfam13360 128 --------GKLVALDPATGKVRWE-----APLAAPRGTNELE------RLVDITGTPVVA-------GGRVFASAYQGRL 181

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556411779  354 TALDINTGKVVWSRqwvhhdvwdyDINSaptLMDITVDGKQipaLVQATKQGFLFVVNRLTGEDVW 419
Cdd:pfam13360 182 VAFDAATGRRLWTR----------EISG---PNGPILDGDL---LYVVSDDGELYALDRATGAVVW 231
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 91-395 7.79e-09

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 58.40  E-value: 7.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  91 SFHGQLNAQKYSPLTQItaDNVNKLTKVWefhTGDVSDGKGDtpatVWSA-TPIFANDTLYIGtpfDR---LIALDPGTG 166
Cdd:PRK11138  22 SFNSEEDVVKMSPLPQV--ENQFTPTTVW---STSVGDGVGD----YYSRlHPAVAYNKVYAA---DRaglVKALDADTG 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 167 KEKWHYDTKSSRKAL--TQPVLKNRGVSywqaknpvkgeACQKMVYMGTVDGKLFALDADSGKPcsgfadngvldlnQWN 244
Cdd:PRK11138  90 KEIWSVDLSEKDGWFskNKSALLSGGVT-----------VAGGKVYIGSEKGQVYALNAEDGEV-------------AWQ 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 245 TvnaKYPLSVLQPPTVVGNHLLVGWAGkdwayaeappGTVFSVNAQTGKLEWTFE-----------AIPAEIrkrTGTAN 313
Cdd:PRK11138 146 T---KVAGEALSRPVVSDGLVLVHTSN----------GMLQALNESDGAVKWTVNldvpsltlrgeSAPATA---FGGAI 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 314 VWThmsadeANGLVYL------------PVSSPSpnywGGNR------VDAIPL---GT--------STTALDINTGKVV 364
Cdd:PRK11138 210 VGG------DNGRVSAvlmeqgqliwqqRISQPT----GATEidrlvdVDTTPVvvgGVvyalayngNLVALDLRSGQIV 279

                        330       340       350
                 ....*....|....*....|....*....|.
gi 556411779 365 WSRqwvhhdvwdyDINSAptlMDITVDGKQI 395
Cdd:PRK11138 280 WKR----------EYGSV---NDFAVDGGRI 297
 
Name Accession Description Interval E-value
PQQ_mGDH cd10280
Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes ...
 89-696 0e+00

Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes belongs to the dehydrogenase family with pyrroloquinoline quinone (PQQ) as cofactor, and is the only subfamily that is bound to the membrane. Glucose dehydrogenase converts D-glucose to D-glucono-1,5-lactone in a reaction that is coupled with the respiratory chain in the periplasmic oxidation of sugars and alcohols in gram-negative bacteria. Ubiquinone functions as the electron acceptor. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199838 [Multi-domain]  Cd Length: 616  Bit Score: 764.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  89 WDSFHGQLNAQKYSPLTQITADNVNKLTKVWEFHTGDVsdGKGDTPATVWSATPIFANDTLYIGTPFDRLIALDPGTGKE 168
Cdd:cd10280    1 WPAYGGDPGGTRYSPLDQITPDNVGKLKVAWTYHTGDL--PGPDGNEGTFEATPLKVGGTLYLCTPHNRVIALDAATGKE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 169 KWHYDTKSSRKALTQPvLKNRGVSYWQAKNPVKgeACQKMVYMGTVDGKLFALDADSGKPCSGFADNGVLDLNQWNTVNA 248
Cdd:cd10280   79 LWRFDPKAGADAAPGH-QTCRGVSYWEDGAAAA--ACARRIFFGTGDARLIALDARTGKPCPDFGDNGVVDLREGLGRVK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 249 KYPLSVLQPPTVVGNHLLVGWAGKDWAYAEAPPGTVFSVNAQTGKLEWTFEAIPAEI---------RKRTGTANVWTHMS 319
Cdd:cd10280  156 PGFYSSTSPPTVYGDLVIVGSAVADNQAVDAPSGVIRAFDVRTGKLVWAFDTIPPPGeagpdtagaWYTRGGPNVWAGMS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 320 ADEANGLVYLPVSSPSPNYWGGNRVDAIPLGTSTTALDINTGKVVWSRQWVHHDVWDYDINSAPTLMDITVDGKQIPALV 399
Cdd:cd10280  236 ADEKLGLVYLPTGSATPDFYGGDRPGDNLFANSLVALDAATGKRRWHFQTVHHDLWDYDLPAQPTLVDVPRDGKTVPAVA 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 400 QATKQGFLFVVNRLTGEDVWPIEERPVPQGDgsVQGEVLSPTQPFPTKPAPLLDQSKKPEIWKLADIVGGGQCSRLWDNL 479
Cdd:cd10280  316 QPTKQGFVFVLDRRTGKPLWPVEERPVPQGD--VPGERTSPTQPFPTLPPPFARQGLTEDDMWGATPFDQLACRIQFRSL 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 480 TYEGMYTPPTTKgeGTLTYPDSAGGVQWGGVAFDPQKQIAIVNTSHIVQYVKLYSREDYDNADKDSGNESGF-----APQ 554
Cdd:cd10280  394 RYEGLFTPPSLD--GTLIFPGNDGGANWGGAAVDPERGILYVNSNRLPFVIQLVPRAPGDPAGVAGGGEGGGggggpSPQ 471

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 555 EGAPYGMRLLVASNWLGMPCWQPPFGEIVAIDMHTGDVKWRRPVGASQQYGFF---MPESWGSPTIGGPAVTAGGVIFIG 631
Cdd:cd10280  472 AGTPYGVGRGRFLSPLGLPCQAPPWGTLTAIDLNTGKILWQVPLGTVPDLGPKgipLPIPTGTPNLGGPVVTAGGLVFIA 551

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556411779 632 ASMDAKVRAYSVESGEELWSDQAEAPAVANPSVYEYKGRQYVAFVAGGNTILKDQVGDQVVVYAL 696
Cdd:cd10280  552 ATQDNYLRAFDKATGKELWEARLPAGGQATPMTYEVDGKQYVVIAAGGHGSLGTKRGDSVIAYAL 616
PQQ_membr_DH TIGR03074
membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; This protein ...
 66-697 0e+00

membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Members of this family have several predicted transmembrane helices in the N-terminal region, and include the quinoprotein glucose dehydrogenase (EC 1.1.5.2) of Escherichia coli and the quinate/shikimate dehydrogenase of Acinetobacter sp. ADP1 (EC 1.1.99.25). Sequences closely related except for the absense of the N-terminal hydrophobic region, scoring in the gray zone between the trusted and noise cutoffs, include PQQ-dependent glycerol (EC 1.1.99.22) and and other polyol (sugar alcohol) dehydrogenases.


Pssm-ID: 274418 [Multi-domain]  Cd Length: 764  Bit Score: 535.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779   66 SGDGKKVASASQPATPLVPGTpTWDSFHGQLNAQKYSPLTQITADNVNKLTKVWEFHTGDVSDGKGDTPATvWSATPIFA 145
Cdd:TIGR03074 116 VGALDTEVPATAAAAPAVPAG-DWAAYGRTQAGQRYSPLDQINPDNVGNLKVAWTYHTGDLKTPDDPGEAT-FQATPLKV 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  146 NDTLYIGTPFDRLIALDPGTGKEKWHYDTKSSRKALTQpVLKNRGVSYWQAKNPVKGEA-------CQKMVYMGTVDGKL 218
Cdd:TIGR03074 194 GDTLYLCTPHNKVIALDAATGKEKWKFDPKLKTEADRQ-HQTCRGVSYYDAPAAAAGPAgpaapadCARRIILPTSDARL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  219 FALDADSGKPCSGFADNGVLDLNQwNTVNAK----YPLSvlqPPTVVGNHLLVGWAGKDWAYAEAPPGTVFSVNAQTGKL 294
Cdd:TIGR03074 273 IALDADTGKLCEDFGNNGTVDLTA-GMGPTPpgyyYPTS---PPLVAGTTVVIGGRVADNYSTDEPSGVIRAFDVNTGAL 348

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  295 EWTFE-------AIPAEIRKRT-GTANVWTHMSADEANGLVYLPVSSPSPNYWGGNRV-DAIPLGTSTTALDINTGKVVW 365
Cdd:TIGR03074 349 VWAWDpgnpdptAPPAPGETYTrNSPNSWSVASYDEKLGLVYLPMGNQTPDQWGGDRTpADEKYSSSLVALDATTGKERW 428

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  366 SRQWVHHDVWDYDINSAPTLMDITV-DGKQIPALVQATKQGFLFVVNRLTGEDVWPIEERPVPQGDgsVQGEVLSPTQPF 444
Cdd:TIGR03074 429 VFQTVHHDLWDMDVPAQPSLVDLPKaDGTTVPALVAPTKQGQIYVLDRRTGEPIVPVEEVPVPQGA--VPGERYSPTQPF 506

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  445 --PTKPAPLLDQSkkpEIW------KLAdivgggqCSRLWDNLTYEGMYTPPTTkgEGTLTYPDSAGGVQWGGVAFDPQK 516
Cdd:TIGR03074 507 svLTFGPPTLTES---DMWgatpfdQLA-------CRIQFKSLRYEGLYTPPSE--QGSLVFPGNLGGFNWGGVAVDPTR 574

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  517 QIAIVNTSHIVQYVKLYSREDYDNADKD---SGNESGFAPQEGAPYGMRLLVASNWLGMPCWQPPFGEIVAIDMHTGDVK 593
Cdd:TIGR03074 575 QVMFVNPMRLPFVSQLVPRAPGDEAPSGakgKGTEMGLNPNKGTPYAVNMNPFLSPLGIPCQAPPWGYMAAIDLKTGKVV 654

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  594 WRRPVGASQQYGFF-----MPESWGSPTIGGPAVTAGGVIFIGASMDAKVRAYSVESGEELWsdQAEAPA--VANPSVY- 665
Cdd:TIGR03074 655 WQHPNGTVRDTGPMgipmpLPIPIGVPTLGGPLATAGGLVFIGATQDNYLRAYDLSTGKELW--EARLPAggQATPMTYm 732

                         650       660       670
                  ....*....|....*....|....*....|..
gi 556411779  666 EYKGRQYVAFVAGGNTILKDQVGDQVVVYALP 697
Cdd:TIGR03074 733 GKDGKQYVVIVAGGHGSSGTKRGDYVIAYALP 764
Gcd COG4993
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
89-697 0e+00

Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];


Pssm-ID: 444017 [Multi-domain]  Cd Length: 515  Bit Score: 527.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  89 WDSFHGQLNAQKYSPLTQITADNVNKLTKVWEFHTGDVsdgkgdtPATVWSATPIFANDTLYIGTPFDRLIALDPGTGKE 168
Cdd:COG4993    5 WLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGDL-------PERGHEATPLVVDGVLYVCTPHNRVFALDAATGKE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 169 KWHYDTKSSRKALTQPVlKNRGVSYWQAKnpvkgeacqkmVYMGTVDGKLFALDADSGKPCsgfadngvldlnqWNTVNA 248
Cdd:COG4993   78 LWRYDPKLPDDAACCDV-VNRGVAYYDGR-----------IFLGTLDGRLVALDAKTGKVC-------------WDVKVG 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 249 KYPL--SVLQPPTVVGNHLLVGWAGKDWAyaeaPPGTVFSVNAQTGKLEWTFEAIP-----------AEIRKRTGTANVW 315
Cdd:COG4993  133 DPKKgyTITSAPLVVKDKVIVGGSGGEFG----PRGVVRAYDARTGKLVWRFDTIPdpgepgaetwpPGDTWKRGGGNVW 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 316 THMSADEANGLVYLPVSSPSPNYWGGNRVDAIPLGTSTTALDINTGKVVWSRQWVHHDVWDYDINSAPTLMDITVDGKQI 395
Cdd:COG4993  209 GTMSYDPELGLVYLPTGNPAPDWNGGQRPGDNLYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDLPVDGKTR 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 396 PALVQATKQGFLFVVNRLTGEDVWpieerpvpqgdgsvqgevlspTQPFpTKPAPLldqSKKPEIWKLADIvgggqcsrl 475
Cdd:COG4993  289 KALVQATKNGFIYVLDRETGEPLV---------------------TQPF-VKPPNW---ATEIDMWGATPI--------- 334

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 476 wdnltyegmYTPPTTKGEGTLTYPDSAGGVQWGGVAFDPQKQIAIVNTSHIVQYVKLYSREdydnadkdsgnesgfaPQE 555
Cdd:COG4993  335 ---------QTPPSLDGKTTLICPGALGGKNWGPAAYDPETGLLYVPANELCMDYELVPRE----------------YQA 389

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 556 GAPY-GMRLLVasnwlgMPCWQPPFGEIVAIDMHTGDVKWRRPVGAsqqygffmpeswgsPTIGGPAVTAGGVIFIGAsM 634
Cdd:COG4993  390 GAPYlGATLTM------YPCPAPPWGTLTAIDLNTGKIVWQVPLGF--------------PNWGGPLATAGGLVFIGT-L 448

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556411779 635 DAKVRAYSVESGEELWSDQAEAPAVANPSVYEYKGRQYVAFVAGGNT----ILKDQVGDQVVVYALP 697
Cdd:COG4993  449 DGYLRAFDAKTGKELWKFRLPSGGQATPMTYEVDGKQYVAVAAGGGGwlglGLYTPQGDYLIAFALP 515
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 84-678 8.60e-74

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 247.98  E-value: 8.60e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  84 PGTPTWDSFHGQLNAQKYSPLTQITADNVNKLTKVWEFHTGDVSDGKgdtpatvwSATPIFANDTLYIGTPFDRLIALDP 163
Cdd:cd10277    6 KETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGGKQRGQ--------ESQPIVNDGVMYVTTSYNRVFAIDA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 164 GTGKEKWHYDTKSSRKALTQPVLKNRGVSYWQAKnpvkgeacqkmVYMGTVDGKLFALDADSGKPCsgfadngvldlnqW 243
Cdd:cd10277   78 KTGKELWKYKHRLPEDIRPCCDVVNRGVALYGDK-----------VYFGTLDAHLVALDAKTGKVV-------------W 133

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 244 NTVNAKYPL--SVLQPPTVVGNHLLVGWAGKDWAYAeappGTVFSVNAQTGKLEWTFEAIPAEIRK-----------RTG 310
Cdd:cd10277  134 KKKVADYKAgySMTLAPLVVKGKVIVGVSGGEFGVR----GFIAALDAETGKEVWRTYTVPGPGEPgstdtwpgdawKTG 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 311 TANVWTHMSADEANGLVYLPVSSPSPnyWGGNRVDAIPLGT-STTALDINTGKVVWSRQWVHHDVWDYDINSAPTLMDIT 389
Cdd:cd10277  210 GGATWLTGTYDPETNLLYWGVGNPAP--WNGDLRPGDNLYTsSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDYT 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 390 VDGKQIPALVQATKQGFLFVVNRLTGEDVWpieerpvpqgdgsvqgevlspTQPFPTKP--APLLDQSKKPEiwkladiv 467
Cdd:cd10277  288 KNGKPVKALVHADRNGFFYVLDRTNGKLIW---------------------ATPFVKKItwASIDLKTGRPI-------- 338

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 468 gggqcsrlwdnltyEGMYTPPTTKGEGTLTYPDSAGGVQWGGVAFDPQKQIAIVNTSHivqyvklySREDYdnadkdSGN 547
Cdd:cd10277  339 --------------YDEDKVPPKKGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVPANH--------WCMDL------TGE 390

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 548 ESGFAPqeGAPY-GMRLLVasnwlgMPCWQPPFGEIVAIDMHTGDVKWRRPVGAsqqygffmpeswgsPTIGGPAVTAGG 626
Cdd:cd10277  391 PVSYKK--GAAYlGAGFTI------KPPFEDHIGELQAIDPTTGKKVWEHKTPL--------------PLWGGVLTTAGG 448

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|..
gi 556411779 627 VIFIGASmDAKVRAYSVESGEELWSDQAEAPAVANPSVYEYKGRQYVAFVAG 678
Cdd:cd10277  449 LVFTGTP-DGYFRAFDAKTGKELWEFQTGSGIIGPPVTWEVDGKQYVAVLSG 499
PQQ_DH_like cd00216
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases ...
 109-695 6.30e-56

PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases with pyrroloquinoline quinone (PQQ) as a cofactor, such as ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller, and the family also includes distantly related proteins which are not enzymatically active and do not bind PQQ.


Pssm-ID: 199833 [Multi-domain]  Cd Length: 434  Bit Score: 197.06  E-value: 6.30e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 109 ADNVNKLTKVWEFHTGDVSDGKGDtpatvwsATPIFANDTLYIGTPFDRLIALDPGTGKEKWHYDTKSSRKALTQ-PVLK 187
Cdd:cd00216    1 ADNVFQLTPAWSFSTGDGGNRGSE-------LTPIVVDGVMYATTSFSRVFALDADDGKEIWSYDPALKDGWFEAcCDLV 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 188 NRGVSYWQAKnpvkgeacqkmVYMGTVDGKLFALDADSGKPCSGFADNGVLDLNqwntvnakyplSVLQPPTVVGNHLLV 267
Cdd:cd00216   74 NRGVAVWGGK-----------VYIGVLDGRVYALNAETGKVAWKVKNADVLGGY-----------TATSAPVVVDGLVII 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 268 GWAGKDWAYAeappGTVFSVNAQTGKLEWTFEAIPAE-------------IRKRTGTANVWTHMSA--------DEANGL 326
Cdd:cd00216  132 GSSGDEFGVR----GYLTAYDVATGEEKWRFYLVMPDpnllpgkdstvtdRNTPTGDEHTWTSGGGtgwssaayDAELNL 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 327 VYLPVSSPSPNYWGGNRVDAIPLGTST-TALDINTGKVVWSRQWVHHDVWDYDINSAPTLMDITVDGKQIPALVQATKQG 405
Cdd:cd00216  208 IYVGGGNPTPWNWGGNRTPGDNLYTSSiVAVNADTGEMKWQYQTTPHDAWDYDGDNTPVLADIKVKGKKVKVLFAPAKNG 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 406 FLFVVNRLTGEDVWPIEErpvpqgdgsvqgevlsptqpfptkpaplldqskkpeiwkladivgggqcsrlwdnltyegmy 485
Cdd:cd00216  288 NFYVLDRRNGELVSARPL-------------------------------------------------------------- 305

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 486 tppttkgegtltypdsaggvqwGGVAFDPQKQIAIVntshivqyvklysredydnadkdsgnesgfapqegapygmrllv 565
Cdd:cd00216  306 ----------------------VPDSYDPDRELFYV-------------------------------------------- 319

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 566 asnwlgmpcwqPPFGEIVAIDMHTGDVKWRRPVgasqqygffmpeswGSPTIGGPAVTAGGVIFIGASmDAKVRAYSVES 645
Cdd:cd00216  320 -----------PANGRIMALDPVTGVVVWEKSE--------------LHPLLGGPLSTAGNLVFVGTS-DGYLKAYNADT 373

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556411779 646 GEELWSDQAEAPAVANPSVYEYKGRQYVAFVAGGNTILKD-----------QVGDQVVVYA 695
Cdd:cd00216  374 GEKLWQQKVPSGFQAEPVTYEVDGEQYVLIQAGGGGAFPLwggmadltrgtQMGGTVVVYK 434
PQQ_ADH_II cd10279
PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of ...
 89-678 5.53e-51

PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of monomeric and soluble type II alcohol dehydrogenases utilizes pyrroloquinoline quinone (PQQ) as a cofactor and is related to ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199837 [Multi-domain]  Cd Length: 549  Bit Score: 186.31  E-value: 5.53e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  89 WDSFHGQLNAQKYSPLTQITADNVNKLTKVWEFHTGDvSDGKgdtpatvwSATPIFANDTLYIGTPFDRLIALDPGTGKE 168
Cdd:cd10279    3 WLSYGRDYDEQRFSPLTQINRSNVGQLGLAWYFDLDT-NRGQ--------EATPLVVDGVMYVSGPWSVVYALDARTGKL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 169 KWHYDTK----SSRKALTQPVlkNRGVSYWQAKnpvkgeacqkmVYMGTVDGKLFALDADSGKpcsgfadngvldlNQW- 243
Cdd:cd10279   74 LWQYDPEvdreSGRKACCDVV--NRGVAVWDGK-----------VFVGTLDGRLIALDAKTGK-------------EVWs 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 244 -NTVNAKYPLSVLQPPTVVGNHLLVGWAGKDWAYAeappGTVFSVNAQTGKLEWTFEAIP------------AEIRKRTG 310
Cdd:cd10279  128 vDTIDPRKPYTITGAPRVAKGKVVIGNGGAEFGVR----GYVSAYDAETGKLVWRFYTVPgnpakpfehaslEAAAATWW 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 311 TA---------NVWTHMSADEANGLVYLPVSSPSPnyWggNRVDAIPLG------TSTTALDINTGKVVWSRQWVHHDVW 375
Cdd:cd10279  204 TGewwrtggggTVWDSITYDPELDLLYIGTGNGSP--W--NRKVRSPGGgdnlflSSIVALDADTGRYKWHYQTTPGDTW 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 376 DYDINSAPTLMDITVDGKQIPALVQATKQGFLFVVNRLTgedvwpieerpvpqgdgsvqGEVLSPTQPFPTKPAPLLD-Q 454
Cdd:cd10279  280 DYTATQPIILADLEIDGKPRKVLMHAPKNGFFYVLDRAT--------------------GKLLSAEPFVPVNWATGIDlK 339

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 455 SKKPeiwkladivgggqcsrlwdNLTYEGMYTPpttkgEGTLTYPDSAGGVQWGGVAFDPQKQIAIVNTSHIVQyvkLYS 534
Cdd:cd10279  340 TGRP-------------------IENPEARYTK-----GPKLVFPGPLGAHNWHPMSYNPDTGLVYIPAQEIPA---VYE 392

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 535 REDYDNADKDSGNESGFAPQEGAPygmrllvaSNWLGMPCWQPPFGEIVAIDMHTGDVKWRRPvgasqqygffMPESWGs 614
Cdd:cd10279  393 DDPGDFGYNPLGWNTGITPDATPP--------PAAAKRALRKATRGRLVAWDPVTQKAAWRVE----------HPGPWN- 453

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556411779 615 ptiGGPAVTAGGVIFIGaSMDAKVRAYSVESGEELWSDQAEAPAVANPSVYEYKGRQYVAFVAG 678
Cdd:cd10279  454 ---GGVLATAGNLVFQG-TADGELAAYDARTGEKLWSFDTGSGIVAAPMTYSVDGEQYVAVLAG 513
PQQ_MDH cd10278
Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the ...
 94-678 2.90e-48

Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the utilization of C1 compounds as a source of energy and carbon by bacteria. It catalyzes the oxidation of methanol to formaldehyde, transfering two electrons per methanol to cytochrome c(L) as the acceptor. Methanol dehydrogenase belongs to a family of dehydrogenases with pyrroloquinoline quinone (PQQ) as cofactor, which also includes dehydrogenases specific to other alcohols and membrane-bound glucose dehydrogenases. This alignment model for the large subunit contains an 8-bladed beta-propeller; the functional enzyme forms a heterotetramer composed of two large and two small subunits.


Pssm-ID: 199836 [Multi-domain]  Cd Length: 553  Bit Score: 178.67  E-value: 2.90e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  94 GQLNAQKYSPLTQITADNVNKLTKVWEFHTGDVSDGKGdtpatvwsaTPIFANDTLYIGTPF-DRLIALD-PGTGKEKWH 171
Cdd:cd10278    6 KDYANTRYSPLAQINKDNVKNLKVAWTFSTGVLRGHEG---------APLVVGDTMYVVTPFpNNVYALDlNDPGKILWK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 172 YDTKSSRKAltQPV----LKNRGVSYWQAKnpvkgeacqkmVYMGTVDGKLFALDADSGKpcsgfadngvldlNQWNTVN 247
Cdd:cd10278   77 YKPKQDPSA--VAVaccdVVNRGLAYADGK-----------IFFNQLDGHLVALDAKTGK-------------EVWKVKN 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 248 A--KYPLSVLQPPTVVGNHLLVGWAGKDWAYAeappGTVFSVNAQTGKLEWTFEA--------IPAEIRK---------- 307
Cdd:cd10278  131 GdpKVGETLTMAPLVVKDKVIVGISGGEFGVR----GYVTAYDLKTGKLVWRAYStgpdkdvlIGPDFNPfnphdggkdl 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 308 ----------RTGTANVWTHMSADEANGLVYLPVSSPSPnyW------GGNRvdaipLGTSTTALDINTGKVVWSRQWVH 371
Cdd:cd10278  207 glstwpgdawKIGGGTNWGWYSYDPKLNLVYYGTGNPGP--WnptqrpGDNK-----WSMTIFARDPDTGEAKWAYQMTP 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 372 HDVWDYDINSAPTLMDITVDGKQIPALVQATKQGFLFVVNRLTGEdvwPIEERPVpqgDGSVQGEVLSPTQPFPTKpapl 451
Cdd:cd10278  280 HDEWDYDGVNEMILVDQTVDGKKRKLLVHFDRNGFVYTLDRTTGE---LLSAEKF---DPVNNWKGVDLKTGRPVK---- 349

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 452 lDQSKKPEiwklADIVGGGQCsrlwdnltyegmytppttkgegtltyPDSAGGVQWGGVAFDPQKQIAIVNTSHIVQyvk 531
Cdd:cd10278  350 -DPEKSTH----MDHNVTDIC--------------------------PSAMGGKDQQPSSYSPKTGLFYVPTNHLCM--- 395

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 532 lysreDYDnadkdsgnesgfaPQE-----GAPYgmrllVASNWLGMPCWQPPFGEIVAIDMHTGDVKWRRPvgasQQYgf 606
Cdd:cd10278  396 -----DYE-------------PFEvnytaGQPY-----VGATLAMYPGPGGHMGQFKAWDPVTGKTKWEIK----ERF-- 446

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556411779 607 fmpeswgsPTIGGPAVTAGGVIFIGaSMDAKVRAYSVESGEELWSDQAEAPAVANPSVYEYKGRQYVAFVAG 678
Cdd:cd10278  447 --------PVWSGTLATAGGLVFYG-TLDGWFKAVDAKTGKLLWKFKLPSGIIGNPITYKHDGKQYVAVLSG 509
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 124-419 1.68e-15

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 76.29  E-value: 1.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  124 GDVSDGKGDTPATVWSAT--------PIFANDTLYIGTPFDRLIALDPGTGKEKWhydtkssRKALTQPVLKNRGVSywq 195
Cdd:pfam13360   3 GVVTALDAATGAELWRVDletglgggVAVDGGRLFVATGGGQLVALDAATGKLLW-------RQTLSGEVLGAPLVA--- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  196 aknpvkgeacQKMVYMGTVDGKLFALDADSGKPcsgfadngvldlnQWNTVNAKYPLSVLQP--PTVVGNHLLVGWAGkd 273
Cdd:pfam13360  73 ----------GGRVFVVAGDGSLIALDAADGRR-------------LWSYQRSGEPLALRSSgsPAVVGDTVVAGFSS-- 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  274 wayaeappGTVFSVNAQTGKLEWTfeaipAEIRKRTGTANVWthmsadEANGLVYLPVSSpspnywgGNRVDAIPLGTST 353
Cdd:pfam13360 128 --------GKLVALDPATGKVRWE-----APLAAPRGTNELE------RLVDITGTPVVA-------GGRVFASAYQGRL 181

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556411779  354 TALDINTGKVVWSRqwvhhdvwdyDINSaptLMDITVDGKQipaLVQATKQGFLFVVNRLTGEDVW 419
Cdd:pfam13360 182 VAFDAATGRRLWTR----------EISG---PNGPILDGDL---LYVVSDDGELYALDRATGAVVW 231
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 90-419 2.04e-14

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 75.35  E-value: 2.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779   90 DSFHGQLNAQKYSPLTQITAdnVNKLTKVWefhTGDVSDGKGDTPATVwsaTPIFANDTLYIGTPFDRLIALDPGTGKEK 169
Cdd:TIGR03300  17 SWFSSEDDEPQPAELPEFQP--TVKVDQVW---SASVGDGVGHYYLRL---QPAVAGGKVYAADADGTVAALDAETGKRL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  170 WHYDTKSsrkALTQPVLKNRGVSY-------------------WQAKnpVKGEAC------QKMVYMGTVDGKLFALDAD 224
Cdd:TIGR03300  89 WRVDLDE---RLSGGVGADGGLVFvgtekgevialdaedgkelWRAK--LSSEVLspplvaNGLVVVRTNDGRLTALDAA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  225 SGKPcsgfadngvldlnQWNTVNAKYPLSVLQ--PPTVVGNHLLVGWAGkdwayaeappGTVFSVNAQTGKLEWtfEAIP 302
Cdd:TIGR03300 164 TGER-------------LWTYSRVTPPLTLRGsaSPVIADGGVLVGFAG----------GKLVALDLQTGQPLW--EQRV 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  303 AEIRKRTGTANVwthmsadeaNGLVYLPVSSpspnywgGNRVDAIPLGTSTTALDINTGKVVWSRqwvhhdvwdyDINSA 382
Cdd:TIGR03300 219 ALPKGRTELERL---------VDVDGDPVVD-------GGQVYAVSYQGRVAALDLRSGRVLWKR----------DASSY 272

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 556411779  383 ptlMDITVDGKQipaLVQATKQGFLFVVNRLTGEDVW 419
Cdd:TIGR03300 273 ---QGPAVDDNR---LYVTDADGVVVALDRRSGSELW 303
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 100-439 3.79e-13

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 71.59  E-value: 3.79e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 100 KYSPLTQIT-ADNVNKLtkvWEFHTGDVSDGKGDTpatvwsaTPIFANDTLYIGTPFDRLIALDPGTGKEKWHYDTksSR 178
Cdd:cd10276    1 PPTDLPEPTpEFDPEVL---WSKSVGNGGMAGIDL-------TPVVAGDMVYAADANGQVSAFNATTGKIIWETSL--SG 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 179 KALtqpvlknrgvsywQAKNPVKGEAcqkMVYMGTVDGKLFALDADSGKPcsgfadngvldlnQWNTvnaKYPLSVLQ-P 257
Cdd:cd10276   69 KGF-------------LGGTPAVGNG---KIFVGTESGYLYALDAKDGSE-------------LWRT---EVSDSQLLsP 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 258 PTVVGNHLLVG-WAGK-----------DWAYAEAPP-----------------------GTVFSVNAQTGKLEWTFEAIP 302
Cdd:cd10276  117 PTYADGKIYVGtGDGRlyycnaetgkvVWNRTSTAPelslrggaapvgaydvvfvgdgnGTVVALNTGTGVDIWEFSVSE 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 303 AEIRkRTGTANVWTHMSADEANGLVYlpVSSPSPNYWGGNRVDAIPL-------GTSTT-----------------ALDI 358
Cdd:cd10276  197 PRGR-TELPRMIDSSVTYVVVGGYLY--STSYQGYLVALDFESGQFLwsrkasgGTSTStdangrvyvgdgegslyCLDA 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 359 NTGKVVWSrqwvhHDVWDYDINSAPTLMDitvdgkQIPALVQATKQGFLFVVNRLTGeDVWPieERPVPQGDGSVQGEVL 438
Cdd:cd10276  274 STGDELWS-----QTVLLGRVLSSPAIYV------GVYIYVTDNAEGYLYCLKDNDG-LTVA--RVEVDYSQYILQGPAV 339


                 .
gi 556411779 439 S 439
Cdd:cd10276  340 S 340
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 97-430 6.17e-13

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 71.00  E-value: 6.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  97 NAQKYSPLTQITadNVNKLTKVWEFHTGDVSDGKGdtpatvWSATPIFANDTLYIGTPFDRLIALDPGTGKEKWHYDTKS 176
Cdd:COG1520   16 DEPPPAPLPEFE--PSVKVKQLWSASVGDGVGKGY------SRLAPAVAGDRVYAADADGRVAALDAATGKELWRVDLGE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 177 ----------------SRKALtqpVL---KNRGVSYWQAKnpVKGEAC------QKMVYMGTVDGKLFALDADSGKPcsg 231
Cdd:COG1520   88 plsggvgadgglvvvgTEDGE---VIaldADDGEELWRAR--LSSEVLaapavaGGRVVVRTGDGRVYALDAATGER--- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 232 fadngvldlnQWNTVNAKYPLSVLQ--PPTVVGNHLLVGWAGkdwayaeappGTVFSVNAQTGKLEWtfEAIPAEIRKRT 309
Cdd:COG1520  160 ----------LWSYQRPVPALTLRGtsSPVIVGGAVLVGFAN----------GKLVALDLANGQPLW--EQRVAQPRGRT 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 310 ---------GTANVwthmsadeANGLVYlpVSSpspnYWGgnrvdaiplgtSTTALDINTGKVVWSRqwvhhdvwdyDIN 380
Cdd:COG1520  218 elerlvdvdGTPVV--------DGGVVY--AVA----YQG-----------RLAALDLRSGRVLWSR----------DLS 262

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 556411779 381 SAptlMDITVDGKQIpalVQATKQGFLFVVNRLTGEDVWPIEE-------RPVPQGD 430
Cdd:COG1520  263 SY---TGLAVDGNNL---YVTDDDGRVWALDRRNGAELWKQDAllyrgltAPVVLGD 313
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 91-395 7.79e-09

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 58.40  E-value: 7.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  91 SFHGQLNAQKYSPLTQItaDNVNKLTKVWefhTGDVSDGKGDtpatVWSA-TPIFANDTLYIGtpfDR---LIALDPGTG 166
Cdd:PRK11138  22 SFNSEEDVVKMSPLPQV--ENQFTPTTVW---STSVGDGVGD----YYSRlHPAVAYNKVYAA---DRaglVKALDADTG 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 167 KEKWHYDTKSSRKAL--TQPVLKNRGVSywqaknpvkgeACQKMVYMGTVDGKLFALDADSGKPcsgfadngvldlnQWN 244
Cdd:PRK11138  90 KEIWSVDLSEKDGWFskNKSALLSGGVT-----------VAGGKVYIGSEKGQVYALNAEDGEV-------------AWQ 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 245 TvnaKYPLSVLQPPTVVGNHLLVGWAGkdwayaeappGTVFSVNAQTGKLEWTFE-----------AIPAEIrkrTGTAN 313
Cdd:PRK11138 146 T---KVAGEALSRPVVSDGLVLVHTSN----------GMLQALNESDGAVKWTVNldvpsltlrgeSAPATA---FGGAI 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 314 VWThmsadeANGLVYL------------PVSSPSpnywGGNR------VDAIPL---GT--------STTALDINTGKVV 364
Cdd:PRK11138 210 VGG------DNGRVSAvlmeqgqliwqqRISQPT----GATEidrlvdVDTTPVvvgGVvyalayngNLVALDLRSGQIV 279

                        330       340       350
                 ....*....|....*....|....*....|.
gi 556411779 365 WSRqwvhhdvwdyDINSAptlMDITVDGKQI 395
Cdd:PRK11138 280 WKR----------EYGSV---NDFAVDGGRI 297
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 578-695 8.92e-07

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 51.56  E-value: 8.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 578 PFGEIVAIDMHTGDVKWRRPVGASQQYGffmpeswgsptiGGPAVtAGGVIFIGaSMDAKVRAYSVESGEELWSDQAEAP 657
Cdd:cd10276   46 ANGQVSAFNATTGKIIWETSLSGKGFLG------------GTPAV-GNGKIFVG-TESGYLYALDAKDGSELWRTEVSDS 111

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 556411779 658 AVANPSVYeYKGRQYVAFVAGGNTILKDQVGDQVVVYA 695
Cdd:cd10276  112 QLLSPPTY-ADGKIYVGTGDGRLYYCNAETGKVVWNRT 148
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 140-431 4.41e-06

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 49.55  E-value: 4.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  140 ATPIFANDTLYIGTPFDRLIALDPGTGKEKWHYDTkssrkalTQPVLKNRGVSywqakNPVkgeACQKMVYMGTVDGKLF 219
Cdd:TIGR03300 139 SPPLVANGLVVVRTNDGRLTALDAATGERLWTYSR-------VTPPLTLRGSA-----SPV---IADGGVLVGFAGGKLV 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  220 ALDADSGKPcsgFADN------GVLDLNQWNTVNAkyplsvlqPPTVVGNHLlvgwagkdwaYAEAPPGTVFSVNAQTGK 293
Cdd:TIGR03300 204 ALDLQTGQP---LWEQrvalpkGRTELERLVDVDG--------DPVVDGGQV----------YAVSYQGRVAALDLRSGR 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  294 LEWtfeaipaeirKRtgtanvwthmsadeanglvylPVSSPSPNYWGGNRVDAIPLGTSTTALDINTGKVVWSR-QWVHH 372
Cdd:TIGR03300 263 VLW----------KR---------------------DASSYQGPAVDDNRLYVTDADGVVVALDRRSGSELWKNdELKYR 311

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556411779  373 DVwdydinSAPTLMDitvdgkqiPALVQATKQGFLFVVNRLTGE-------DVWPIEERPVPQGDG 431
Cdd:TIGR03300 312 QL------TAPAVLG--------GYLVVGDFEGYLHWLDRDDGSfvarlktDGSGIASPPVVVGDG 363
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 578-682 8.03e-06

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 47.78  E-value: 8.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  578 PFGEIVAIDMHTGDVKWRRpvgasqqygffmpeSWGSPTIGGPAVtAGGVIFIgASMDAKVRAYSVESGEELWSDQAEAP 657
Cdd:pfam13360   1 ADGVVTALDAATGAELWRV--------------DLETGLGGGVAV-DGGRLFV-ATGGGQLVALDAATGKLLWRQTLSGE 64

                          90       100
                  ....*....|....*....|....*
gi 556411779  658 AVANPSVYEykGRQYVafVAGGNTI 682
Cdd:pfam13360  65 VLGAPLVAG--GRVFV--VAGDGSL 85
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 579-691 2.04e-05

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 46.63  E-value: 2.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  579 FGEIVAIDMHTGDVKWRRPVGAsqqygffmpeswgsPTIGGPAVtAGGVIFIGASmDAKVRAYSVESGEELWSDQAEAPA 658
Cdd:pfam13360  42 GGQLVALDAATGKLLWRQTLSG--------------EVLGAPLV-AGGRVFVVAG-DGSLIALDAADGRRLWSYQRSGEP 105

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 556411779  659 VA---NPSVYEYKGRQYVAFVAGGNTILKDQVGDQV 691
Cdd:pfam13360 106 LAlrsSGSPAVVGDTVVAGFSSGKLVALDPATGKVR 141
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 544-666 2.27e-05

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 47.12  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 544 DSGNESGFAPQEGAPYGMRLLVASnwlgmpcwqpPFGEIVAIDMHTGDVKWRRPVGasqqygffmpeswgSPTIGGPAVt 623
Cdd:COG1520   41 GDGVGKGYSRLAPAVAGDRVYAAD----------ADGRVAALDAATGKELWRVDLG--------------EPLSGGVGA- 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 556411779 624 AGGVIFIGaSMDAKVRAYSVESGEELWSDQAEAPAVANPSVYE 666
Cdd:COG1520   96 DGGLVVVG-TEDGEVIALDADDGEELWRARLSSEVLAAPAVAG 137
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 580-666 4.01e-05

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 46.46  E-value: 4.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 580 GEIVAIDMHTGDVKWRRPVgaSQQYGFFmPESWGSPTIGGPAVtAGGVIFIGaSMDAKVRAYSVESGEELWSDQAEAPAV 659
Cdd:PRK11138  79 GLVKALDADTGKEIWSVDL--SEKDGWF-SKNKSALLSGGVTV-AGGKVYIG-SEKGQVYALNAEDGEVAWQTKVAGEAL 153


                 ....*..
gi 556411779 660 ANPSVYE 666
Cdd:PRK11138 154 SRPVVSD 160
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 580-658 4.44e-05

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 46.46  E-value: 4.44e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556411779  580 GEIVAIDMHTGDVKWRRPVGASqqygffmpeswgspTIGGPAVTAGGVIFIGAsmDAKVRAYSVESGEELWSDQAEAPA 658
Cdd:TIGR03300 115 GEVIALDAEDGKELWRAKLSSE--------------VLSPPLVANGLVVVRTN--DGRLTALDAATGERLWTYSRVTPP 177
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 580-658 7.81e-05

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 45.57  E-value: 7.81e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556411779 580 GEIVAIDMHTGDVKWRRPVGAsqqygffmpESWGSPTIggpavtAGGVIFIgASMDAKVRAYSVESGEELWSDQAEAPA 658
Cdd:COG1520  107 GEVIALDADDGEELWRARLSS---------EVLAAPAV------AGGRVVV-RTGDGRVYALDAATGERLWSYQRPVPA 169
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 580-680 3.22e-04

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 43.47  E-value: 3.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 580 GEIVAIDMHTGDVKWRRPVGASQqygffmpeswgsptIGGPAVTAGGVIFIGASmDAKVRAYSVESGEELWSDQAEAPAV 659
Cdd:cd10276   90 GYLYALDAKDGSELWRTEVSDSQ--------------LLSPPTYADGKIYVGTG-DGRLYYCNAETGKVVWNRTSTAPEL 154

                         90       100
                 ....*....|....*....|.
gi 556411779 660 ANPSVYEYKGRQYVAFVAGGN 680
Cdd:cd10276  155 SLRGGAAPVGAYDVVFVGDGN 175
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 578-661 1.00e-03

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 41.84  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779  578 PFGEIVAIDMHTGDVKWRRPVGasqqygffmpeswgSPTIGGPAVtAGGVIFIGaSMDAKVRAYSVESGEELW-----SD 652
Cdd:TIGR03300  73 ADGTVAALDAETGKRLWRVDLD--------------ERLSGGVGA-DGGLVFVG-TEKGEVIALDAEDGKELWraklsSE 136


                  ....*....
gi 556411779  653 QAEAPAVAN 661
Cdd:TIGR03300 137 VLSPPLVAN 145
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 141-222 5.31e-03

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 39.62  E-value: 5.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556411779 141 TPIFANDTLYIGTPFDRLIALDPGTGKEKWHYDTKSSRKaLTQPV-------------------LKNRGVSYWQAKNPVK 201
Cdd:cd10276  251 TSTDANGRVYVGDGEGSLYCLDASTGDELWSQTVLLGRV-LSSPAiyvgvyiyvtdnaegylycLKDNDGLTVARVEVDY 329

                         90       100
                 ....*....|....*....|....*...
gi 556411779 202 GEACQ-------KMVYMGTVDGKLFALD 222
Cdd:cd10276  330 SQYILqgpavsdGWLYYGTDDGYLYALT 357
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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