NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|556424572|ref|WP_023309499|]
View 

MULTISPECIES: YdgH/BhsA/McbA-like domain containing protein [Enterobacter]

Protein Classification

DUF1471 domain-containing protein( domain architecture ID 28000)

DUF1471 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
YdgH_BhsA-like super family cl11507
YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around ...
 7-89 5.41e-15

YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around 90 residues in length, including E. coli YdgH, YhcN, BhsA and McbA, which play a role in stress response, biofilm formation and pathogenesis. BhsA (also known as ComC) reduces the permeability of the outer membrane to copper and may decrease biofilm formation by repressing cell-cell interaction and cell surface interaction. Members of this entry have one copy of this domain with the exception of YdgH, which has three copies. The function of this domain is unknown, however, it is suggested to be directly involved in host-pathogen interaction.


The actual alignment was detected with superfamily member PRK09929:

Pssm-ID: 448290  Cd Length: 91  Bit Score: 63.78  E-value: 5.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556424572  7 IVTSLVIGSLSF---GVFAAKELEK---DKVAGmNLTKIGEISTSDTTAPMDARKELSKKADELGGTYYVVTSAEKQTKn 80
Cdd:PRK09929  3 IISKMLLGALAFavtNVYAAELMTKaefEKVES-QYEKIGTISTSNEMSTADAKEDLIKKADEKGADVLVLTSGQTDNK- 80


                ....*....
gi 556424572 81 VRATADVYK 89
Cdd:PRK09929 81 IHGTADIYK 89
 
Name Accession Description Interval E-value
PRK09929 PRK09929
hypothetical protein; Provisional
 7-89 5.41e-15

hypothetical protein; Provisional


Pssm-ID: 182151  Cd Length: 91  Bit Score: 63.78  E-value: 5.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556424572  7 IVTSLVIGSLSF---GVFAAKELEK---DKVAGmNLTKIGEISTSDTTAPMDARKELSKKADELGGTYYVVTSAEKQTKn 80
Cdd:PRK09929  3 IISKMLLGALAFavtNVYAAELMTKaefEKVES-QYEKIGTISTSNEMSTADAKEDLIKKADEKGADVLVLTSGQTDNK- 80


                ....*....
gi 556424572 81 VRATADVYK 89
Cdd:PRK09929 81 IHGTADIYK 89
YdgH_BhsA-like pfam07338
YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around ...
 36-88 1.16e-13

YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around 90 residues in length, including E. coli YdgH, YhcN, BhsA and McbA, which play a role in stress response, biofilm formation and pathogenesis. BhsA (also known as ComC) reduces the permeability of the outer membrane to copper and may decrease biofilm formation by repressing cell-cell interaction and cell surface interaction. Members of this entry have one copy of this domain with the exception of YdgH, which has three copies. The function of this domain is unknown, however, it is suggested to be directly involved in host-pathogen interaction.


Pssm-ID: 429417 [Multi-domain]  Cd Length: 55  Bit Score: 59.46  E-value: 1.16e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 556424572  36 LTKIGEISTS-DTTAPMDARKELSKKADELGGTYYVVTSA-EKQTKNVRATADVY 88
Cdd:pfam07338  1 LQPIGTVSVSgVFGSPSDAEAALSKKADAKGAKSYRIISAdEPNGGNWHGTAELY 55
ydgH_STM1478 NF040471
DUF1471 family protein YdgH; YdgH is the rare paralog in the DUF1471 family (PF07338) with ...
 1-89 8.46e-07

DUF1471 family protein YdgH; YdgH is the rare paralog in the DUF1471 family (PF07338) with three tandem copies of the DUF1471 domain instead of just one. Note that STM1478 from the Salmonella enterica model strain LT2 is also called SssB.


Pssm-ID: 439699 [Multi-domain]  Cd Length: 317  Bit Score: 44.70  E-value: 8.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556424572   1 MKLVTGIVTSLVIGSLS--FGVFAAKELEKDKVAgmNLTKIGEIS-TSDTTAPMDARKELSKKADELGG-TYYVV-TSAE 75
Cdd:NF040471   1 MKLKNTILASALLLSLTalSSAQAAQELTPEKAA--ALKPFDRITvTGRFNAIYEAADAVSRRADKMGAaSFYIQdTNDV 78

                         90
                 ....*....|....
gi 556424572  76 KQTKNVRATADVYK 89
Cdd:NF040471  79 NNSGNWRVTADLYH 92
 
Name Accession Description Interval E-value
PRK09929 PRK09929
hypothetical protein; Provisional
 7-89 5.41e-15

hypothetical protein; Provisional


Pssm-ID: 182151  Cd Length: 91  Bit Score: 63.78  E-value: 5.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556424572  7 IVTSLVIGSLSF---GVFAAKELEK---DKVAGmNLTKIGEISTSDTTAPMDARKELSKKADELGGTYYVVTSAEKQTKn 80
Cdd:PRK09929  3 IISKMLLGALAFavtNVYAAELMTKaefEKVES-QYEKIGTISTSNEMSTADAKEDLIKKADEKGADVLVLTSGQTDNK- 80


                ....*....
gi 556424572 81 VRATADVYK 89
Cdd:PRK09929 81 IHGTADIYK 89
YdgH_BhsA-like pfam07338
YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around ...
 36-88 1.16e-13

YdgH/BhsA/McbA-like domain; This domain is found in several Enterobacterial proteins of around 90 residues in length, including E. coli YdgH, YhcN, BhsA and McbA, which play a role in stress response, biofilm formation and pathogenesis. BhsA (also known as ComC) reduces the permeability of the outer membrane to copper and may decrease biofilm formation by repressing cell-cell interaction and cell surface interaction. Members of this entry have one copy of this domain with the exception of YdgH, which has three copies. The function of this domain is unknown, however, it is suggested to be directly involved in host-pathogen interaction.


Pssm-ID: 429417 [Multi-domain]  Cd Length: 55  Bit Score: 59.46  E-value: 1.16e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 556424572  36 LTKIGEISTS-DTTAPMDARKELSKKADELGGTYYVVTSA-EKQTKNVRATADVY 88
Cdd:pfam07338  1 LQPIGTVSVSgVFGSPSDAEAALSKKADAKGAKSYRIISAdEPNGGNWHGTAELY 55
ydgH_STM1478 NF040471
DUF1471 family protein YdgH; YdgH is the rare paralog in the DUF1471 family (PF07338) with ...
 1-89 8.46e-07

DUF1471 family protein YdgH; YdgH is the rare paralog in the DUF1471 family (PF07338) with three tandem copies of the DUF1471 domain instead of just one. Note that STM1478 from the Salmonella enterica model strain LT2 is also called SssB.


Pssm-ID: 439699 [Multi-domain]  Cd Length: 317  Bit Score: 44.70  E-value: 8.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556424572   1 MKLVTGIVTSLVIGSLS--FGVFAAKELEKDKVAgmNLTKIGEIS-TSDTTAPMDARKELSKKADELGG-TYYVV-TSAE 75
Cdd:NF040471   1 MKLKNTILASALLLSLTalSSAQAAQELTPEKAA--ALKPFDRITvTGRFNAIYEAADAVSRRADKMGAaSFYIQdTNDV 78

                         90
                 ....*....|....
gi 556424572  76 KQTKNVRATADVYK 89
Cdd:NF040471  79 NNSGNWRVTADLYH 92
PRK10259 PRK10259
hypothetical protein; Provisional
 1-89 2.47e-06

hypothetical protein; Provisional


Pssm-ID: 137782  Cd Length: 86  Bit Score: 41.63  E-value: 2.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556424572  1 MKLVTGIVTSLVIGSLSFGVFAAKELEKDKVAGMNltKIGEISTSDTTAPMDARKELSKKADELGGTYYVVTSAEKQTKn 80
Cdd:PRK10259  1 MKTINTVVAAMALSTLSFGVFAAEPVTASQAQNMN--KIGVVSADGASTLDALEAKLAEKAAAAGASGYSITSATNNNK- 77


                ....*....
gi 556424572 81 VRATADVYK 89
Cdd:PRK10259 78 LSGTAVIYK 86
PRK14864 PRK14864
biofilm peroxide resistance protein BsmA;
23-71 1.58e-04

biofilm peroxide resistance protein BsmA;


Pssm-ID: 184866  Cd Length: 104  Bit Score: 36.94  E-value: 1.58e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 556424572  23 AKELEKDKVAGmnLTKIGEISTSDTTAPMDARKELSKKADELGGTYYVV 71
Cdd:PRK14864  37 AQEIRRAQTQG--LQKMGTVSALVRGSPDDAEREIQAKANAAGADYYVI 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH