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Conserved domains on  [gi|556425838|ref|WP_023310765|]
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MULTISPECIES: glucosamine-6-phosphate deaminase [Enterobacterales]

Protein Classification

glucosamine-6-phosphate deaminase( domain architecture ID 10794581)

glucosamine-6-phosphate deaminase catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and an ammonium ion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-259 0e+00

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


:

Pssm-ID: 129593  Cd Length: 259  Bit Score: 498.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838    1 MRLIPLATAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKD 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838   81 HPESYHSFMHRNFFDHVDIPSENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  161 TLTHDTRVANSRFFDGDVNQVPKYALTVGVGTLLDAEEVMILVLGGVKAQALQAAVEGNVNHMWTISCLQLHPKSVIVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*....
gi 556425838  241 EPSTMELKVKTLKYFNELE 259
Cdd:TIGR00502 241 ENATQELKVKTVEYFNELE 259
 
Name Accession Description Interval E-value
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-259 0e+00

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 498.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838    1 MRLIPLATAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKD 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838   81 HPESYHSFMHRNFFDHVDIPSENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  161 TLTHDTRVANSRFFDGDVNQVPKYALTVGVGTLLDAEEVMILVLGGVKAQALQAAVEGNVNHMWTISCLQLHPKSVIVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*....
gi 556425838  241 EPSTMELKVKTLKYFNELE 259
Cdd:TIGR00502 241 ENATQELKVKTVEYFNELE 259
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-261 2.03e-179

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 493.58  E-value: 2.03e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838   1 MRLIPLATAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKD 80
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  81 HPESYHSFMHRNFFDHVDIPSENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838 161 TLTHDTRVANSRFFDGDVNQVPKYALTVGVGTLLDAEEVMILVLGGVKAQALQAAVEGNVNHMWTISCLQLHPKSVIVCD 240
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250       260
                 ....*....|....*....|.
gi 556425838 241 EPSTMELKVKTLKYFNELEAE 261
Cdd:PRK00443 241 EAAASELKVKTVKYFTELEAE 261
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-247 4.33e-133

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 375.28  E-value: 4.33e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  10 EQVGKWAARHIVNRINAFKPtadrpFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKDHPESYHSFM 89
Cdd:cd01399    1 EEMSEAAAELIAELIREKPP-----AVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFM 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  90 HRNFFDHVDIPSENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVA 169
Cdd:cd01399   76 RENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQA 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556425838 170 NSRFFDGDvNQVPKYALTVGVGTLLDAEEVMILVLGGVKAQALQAAVEGNVNHMWTISCLQLHPKSVIVCDEPSTMEL 247
Cdd:cd01399  156 NARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-248 1.76e-119

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 341.37  E-value: 1.76e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838   1 MRLIPLATAEQVGKWAARHIVNRINAFkpTADRP-FVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPK 79
Cdd:COG0363    2 MRVIIFPDAEELAAAAAERAAERIAEA--IAEKGrAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGLPP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  80 DHPESYHSFMHRNFFDHVDIPSENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRT-R 158
Cdd:COG0363   80 DHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSETdR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838 159 IKTLTHDTRVANSRFFDgDVNQVPKYALTVGVGTLLDAEEVMILVLGGVKAQALQAAVEGNVNHMWTISCLQLHPKSVIV 238
Cdd:COG0363  160 VVTLDESTRQANARFFG-SIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWF 238

                        250
                 ....*....|
gi 556425838 239 CDEPSTMELK 248
Cdd:COG0363  239 LDEAAASLLT 248
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
7-223 1.44e-25

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 100.39  E-value: 1.44e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838    7 ATAEQVGKWAARHIVNRINAFkpTADR-PFVLGLPTGGTPLTAYKALVEMHkaGQVSFKHVVTFNMDE-YVglPKDHPES 84
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAA--LAERgRFTLALSGGSTPKPLYELLAAAP--ARLDWSRVHVFWGDErCV--PPDDPDS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838   85 YHSFMHRNFFDHVDIPSENINLLNGNAPDIDAECRQYEEKIRSYGK---------IHLfmgGVGNDGHIA--F-NEPAss 152
Cdd:pfam01182  75 NYGMAREALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvfdlVLL---GMGPDGHTAslFpGSPA-- 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556425838  153 LASRTRIKTLTHDTRVAnsrffdgdvnqvPKYALTVGVGTLLDAEEVMILVLGGVKAQALQAAVEGNVNHM 223
Cdd:pfam01182 150 LEETDRLVVAVTDSPKP------------PPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDPL 208
 
Name Accession Description Interval E-value
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-259 0e+00

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 498.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838    1 MRLIPLATAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKD 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838   81 HPESYHSFMHRNFFDHVDIPSENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  161 TLTHDTRVANSRFFDGDVNQVPKYALTVGVGTLLDAEEVMILVLGGVKAQALQAAVEGNVNHMWTISCLQLHPKSVIVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*....
gi 556425838  241 EPSTMELKVKTLKYFNELE 259
Cdd:TIGR00502 241 ENATQELKVKTVEYFNELE 259
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-261 2.03e-179

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 493.58  E-value: 2.03e-179
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838   1 MRLIPLATAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKD 80
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  81 HPESYHSFMHRNFFDHVDIPSENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838 161 TLTHDTRVANSRFFDGDVNQVPKYALTVGVGTLLDAEEVMILVLGGVKAQALQAAVEGNVNHMWTISCLQLHPKSVIVCD 240
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250       260
                 ....*....|....*....|.
gi 556425838 241 EPSTMELKVKTLKYFNELEAE 261
Cdd:PRK00443 241 EAAASELKVKTVKYFTELEAE 261
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-253 5.06e-146

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 408.76  E-value: 5.06e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838   1 MRLIPLATAEQVGKWAARHIVNRINAFKPTADRPFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKD 80
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  81 HPESYHSFMHRNFFDHVDIPSENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIK 160
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838 161 TLTHDTRVANSRFFDGDVNQVPKYALTVGVGTLLDAEEVMILVLGGVKAQALQAAVEGNVNHMWTISCLQLHPKSVIVCD 240
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                        250
                 ....*....|...
gi 556425838 241 EPSTMELKVKTLK 253
Cdd:PTZ00285 241 EDATLELKVKTTK 253
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 10-247 4.33e-133

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 375.28  E-value: 4.33e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  10 EQVGKWAARHIVNRINAFKPtadrpFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKDHPESYHSFM 89
Cdd:cd01399    1 EEMSEAAAELIAELIREKPP-----AVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFM 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  90 HRNFFDHVDIPSENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVA 169
Cdd:cd01399   76 RENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQA 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556425838 170 NSRFFDGDvNQVPKYALTVGVGTLLDAEEVMILVLGGVKAQALQAAVEGNVNHMWTISCLQLHPKSVIVCDEPSTMEL 247
Cdd:cd01399  156 NARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-248 1.76e-119

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 341.37  E-value: 1.76e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838   1 MRLIPLATAEQVGKWAARHIVNRINAFkpTADRP-FVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPK 79
Cdd:COG0363    2 MRVIIFPDAEELAAAAAERAAERIAEA--IAEKGrAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGLPP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  80 DHPESYHSFMHRNFFDHVDIPSENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRT-R 158
Cdd:COG0363   80 DHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSETdR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838 159 IKTLTHDTRVANSRFFDgDVNQVPKYALTVGVGTLLDAEEVMILVLGGVKAQALQAAVEGNVNHMWTISCLQLHPKSVIV 238
Cdd:COG0363  160 VVTLDESTRQANARFFG-SIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVTWF 238

                        250
                 ....*....|
gi 556425838 239 CDEPSTMELK 248
Cdd:COG0363  239 LDEAAASLLT 248
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 16-247 1.98e-81

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 257.26  E-value: 1.98e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  16 AARHIVNRINAF---KPTADRPFVLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKDHPESYHSFMHRN 92
Cdd:PRK02122  39 ASRAVAQEIATLireRQAEGKPCVLGLATGSSPIGVYAELIRMHREEGLSFKNVITFNLDEYYPMQPDSLQSYHRFMKEN 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  93 FFDHVDIPSENINLLNGNAP--DIDAECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLTHDTRVAN 170
Cdd:PRK02122 119 LFDHVDIPPENIHIPDGTIPkeEIDEYCRDYEEKIEAAGGIDFQLLGIGRTGHIGFNEPGSGRNSRTRLVTLDHITRRDA 198

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556425838 171 SRFFdGDVNQVPKYALTVGVGTLLDAEEVMILVLGGVKAQALQAAVEGNVNHMWTISCLQLHPKSVIVCDEPSTMEL 247
Cdd:PRK02122 199 ASDF-FGEENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYLQEHPNATFVLDLAAASEL 274
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 13-239 1.93e-72

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 219.15  E-value: 1.93e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  13 GKWAARHIVNRINAFkPTADRPFVLGLPTGGTPLTAYKALVEMHKAGqvSFKHVVTFNMDEYVGLPkDHPESYHSFMHRN 92
Cdd:cd00458    1 AKEALKFIEDK*EKL-LEEKDDMVIGLGTGSTPAYFYKLLGEKLKRG--EISDIVGFPTDERYVPL-DSDQSNFRQAKLL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  93 FFDHVDIPSENINLLNGNAPDIDAECRQYEEKIRSYGKIHLFMGGVGNdghiafnepasslasrtriktlthdtrvansr 172
Cdd:cd00458   77 AFEHDIIPASNVHYVDTSLPIEKACEKYEREILDQVDAIDLAVDGAGY-------------------------------- 124

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556425838 173 ffdgdvnqvpkyaltvgvgtllDAEEVMILVLGGVKAQALQAAVEGNVNHMWTISCLQLHPKSVIVC 239
Cdd:cd00458  125 ----------------------RAGTVIVLVDGRKKVDYLCQNTEPGVIENGIFADIRGKEKDIVIV 169
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 36-240 4.54e-34

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 123.02  E-value: 4.54e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  36 VLGLPTGGTPLTAYKALVEMHKAGQVSFKHVVTFNMDEYVGLPKDHPESYHSFMHRNFFDHVDIPSENINLLNGNAPDiD 115
Cdd:PRK09762  31 VICLATGATPLLTYHYLVEKIHQQQVDVSQLTFVKLDEWVDLPLTMPGTCETFLQQHIVQPLGLREDQLISFRSEEIN-E 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838 116 AECRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPASSLASRTRIKTLthDTRVANSRFFDGDvNQVPKYALTVGVGTLLD 195
Cdd:PRK09762 110 TECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGESLQPACHISQL--DARTQQHEMLKTA-GRPVTRGITLGLKDILN 186

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 556425838 196 AEEVMILVLGGVKAQALQAAVEGNVNHMWTISCLQLHPKSV-IVCD 240
Cdd:PRK09762 187 AREVLLLVTGEGKQDATERFLTAKVSTAIPASFLWLHSNFIcLIDR 232
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
7-223 1.44e-25

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 100.39  E-value: 1.44e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838    7 ATAEQVGKWAARHIVNRINAFkpTADR-PFVLGLPTGGTPLTAYKALVEMHkaGQVSFKHVVTFNMDE-YVglPKDHPES 84
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAA--LAERgRFTLALSGGSTPKPLYELLAAAP--ARLDWSRVHVFWGDErCV--PPDDPDS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838   85 YHSFMHRNFFDHVDIPSENINLLNGNAPDIDAECRQYEEKIRSYGK---------IHLfmgGVGNDGHIA--F-NEPAss 152
Cdd:pfam01182  75 NYGMAREALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvfdlVLL---GMGPDGHTAslFpGSPA-- 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556425838  153 LASRTRIKTLTHDTRVAnsrffdgdvnqvPKYALTVGVGTLLDAEEVMILVLGGVKAQALQAAVEGNVNHM 223
Cdd:pfam01182 150 LEETDRLVVAVTDSPKP------------PPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDPL 208
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-247 7.13e-22

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 90.97  E-value: 7.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838   1 MRLIPLATAEQVGKWAARHIVNRInafkpTADRPFVLGLPTGGTPLTAYKALVEMHKaGQVSFKHVVTFNMDEyvgLPKD 80
Cdd:PRK12358   1 MKIIITKDYEEMSRVAAHHLLGYM-----SKTKRVNLAITAGSTPKGMYEYLITLVK-GKAWYDNVHYYNFDE---IPFR 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  81 HPESYH---SFMHRNFFDHVDIPSENINLLN-GNApdidaecRQYEEKIRSYGKIHLFMGGVGNDGHIAFNEPA-SSLAS 155
Cdd:PRK12358  72 GKEGEGvtiTNLRNLFFTPAGIKEENIHKLTiDNY-------REHDQKLARDGGLDLVVLGLGADGHFCGNLPGtTHFHD 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838 156 RTRIKTLTHDTR--VANSRFfDGDVNQVPKYALTVGVGTLLDAEEVMILVLGGVKAQALQAAVEGNVNHMWTISCLQLHP 233
Cdd:PRK12358 145 ETVEVPIQGEMVdiVAHGEL-GGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHP 223

                        250
                 ....*....|....
gi 556425838 234 KSVIVCDEPSTMEL 247
Cdd:PRK12358 224 NLTVILDEAAAAEL 237
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 10-239 8.63e-21

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 87.62  E-value: 8.63e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  10 EQVGKWAARHIVNRINAfKPTADRPFVLGLPTGGTPLTAYKALVEMHkagQVSFKHVVTFNMDE-YVglPKDHPESYHSF 88
Cdd:cd01400    1 EALAEALADRIAEALAA-AIAKRGRFSLALSGGSTPKPLYELLAAAP---ALDWSKVHVFLGDErCV--PPDDPDSNYRL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  89 MHRNFFDHVDIPSENINLLNGNApDIDAECRQYEEKIRS----YGKIHLFMGGVGNDGHIA--FNEPASSLASRTRIKTL 162
Cdd:cd01400   75 AREALLSHVAIPAANIHPIPTEL-GPEDAAAAYEKELRAlfggVPPFDLVLLGMGPDGHTAslFPGHPALLEETDRLVVA 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556425838 163 THDTRVAnsrffdgdvnqvPKYALTVGVGTLLDAEEVMILVLGGVKAQALQAAVEGNVNHMWTISCLQLHPKSVIVC 239
Cdd:cd01400  154 VTDSPKP------------PPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPGEVLWF 218
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 35-242 2.53e-16

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 75.87  E-value: 2.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838   35 FVLGLPTGGTPLTAYKALVEMhkagQVSFKHVVTFNMDE-YVglPKDHPESYHSFMHRNFFDHVDIPSENINLLNGNAPD 113
Cdd:TIGR01198  30 FSLALSGGRSPIALLEALAAQ----PLDWSRIHLFLGDErYV--PLDHADSNTGLAREALLDRVAIPASNIHPMPTELSD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  114 IDAECRQYEEKIRSY------GKIHLFMGGVGNDGHIA--FNEpasSLASRTRIKTLThdtrvansrFFDGDVNQvPKYA 185
Cdd:TIGR01198 104 IEEAAELYEQELAAAfqpivfPVFDLLLLGMGPDGHTAslFPH---TPALQETERLVT---------VLTKSPKP-PHER 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 556425838  186 LTVGVGTLLDAEEVMILVLGGVKAQALQAAVE-GNVNHMWTISCLQLHPKSVIVCDEP 242
Cdd:TIGR01198 171 ITLTLPAINAARKVFLLIAGEEKRNALAEALAvEAEPYPLPAAGVLHSGKTLWLLDYA 228
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 69-217 1.59e-03

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 39.07  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838  69 FNMDEYVgLPKDHPESYHSFMHRNFFDHVDIPSENINLLNGNAPDIDAeCRQYEEKIRSYGKIH--------------LF 134
Cdd:PLN02360  77 FWADERV-VAKNHADSNYKLAKDGLLSKVPVVPSHVYSINDTVTAEEA-ATDYEFAIRQLVKTRtigvsdisdcpkfdLI 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556425838 135 MGGVGNDGHIAF---NEPASSLASrtriKTLTHDTrvansrffdgDVNQVPKYALTVGVGTLLDAEEVMILVLGGVKAQA 211
Cdd:PLN02360 155 LLGMGSDGHVASlfpNHPALEEKD----DWVTFIT----------DSPKPPPERITFTLPVINSASNVAVVATGESKANA 220


                 ....*.
gi 556425838 212 LQAAVE 217
Cdd:PLN02360 221 VHLAID 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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