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Conserved domains on  [gi|556426413|ref|WP_023311340|]
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MULTISPECIES: amino acid ABC transporter permease [Enterobacter]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 2-235 3.31e-47

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 156.00  E-value: 3.31e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413   2 PALDWQGVLtgQPLQWILSGFLTTLWVTLAGMLLASLLALLFMLLRLSGGRPGNAVVSSWVSLFRNTPLLVQLLFWYFaa 81
Cdd:COG0765    1 MFFDFSVLL--DYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYF-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  82 wnGLPQAFRDavnadhswsilpgnvwwfTPEFLCSAWGLGVFTSAFLIEEVESGLRSVPAGQREAALAQGFSAWRLFRYI 161
Cdd:COG0765   77 --GLPLLGID------------------LSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRI 136

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556426413 162 LLPQGLANAWQPVVGQYLNLMKLSSLASGIGFAELTYQVRQIESYNAHALEAFTLGTALYLLTGLVMGMVLVRI 235
Cdd:COG0765  137 ILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRL 210
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 2-235 3.31e-47

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 156.00  E-value: 3.31e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413   2 PALDWQGVLtgQPLQWILSGFLTTLWVTLAGMLLASLLALLFMLLRLSGGRPGNAVVSSWVSLFRNTPLLVQLLFWYFaa 81
Cdd:COG0765    1 MFFDFSVLL--DYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYF-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  82 wnGLPQAFRDavnadhswsilpgnvwwfTPEFLCSAWGLGVFTSAFLIEEVESGLRSVPAGQREAALAQGFSAWRLFRYI 161
Cdd:COG0765   77 --GLPLLGID------------------LSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRI 136

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556426413 162 LLPQGLANAWQPVVGQYLNLMKLSSLASGIGFAELTYQVRQIESYNAHALEAFTLGTALYLLTGLVMGMVLVRI 235
Cdd:COG0765  137 ILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRL 210
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 5-235 1.16e-17

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 78.94  E-value: 1.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413   5 DWQGVLTGQPLqwILSGFLTTLWVTLAGMLLASLLALLFMLLRLSGGRPGNAVVSSWVSLFRNTPLLVQLLFWYFAawng 84
Cdd:PRK09494   4 DWSAIWPAIPL--LLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFA---- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  85 LPQAFRDaVNADhswsilpgnvwwftpEFLCSAWGLGVFTSAFLIEEVESGLRSVPAGQREAALAQGFSAWRLFRYILLP 164
Cdd:PRK09494  78 LPMAFND-LRID---------------PFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGP 141

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556426413 165 QGLANAWQPVVGQYLNLMKLSSLASGIGFAELTYQVRQIESYNAHALEAFTLGTALYLLTGLVMGMVLVRI 235
Cdd:PRK09494 142 LALRRMLPPLGNQWIISIKDTSLFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRL 212
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 51-233 3.13e-09

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 54.98  E-value: 3.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  51 GRPGNAVVSSWVSLFRNTPLLVQLLFWYFAAWNGLPqafrdavnadhsWSILPGNVWWftpeflcSAWGLGVFTSAFLIE 130
Cdd:cd06261   30 RGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLG------------WGILPGLGLP-------ALILALLLIAPFARL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413 131 EVESGLRSVPAGQREAALAQGFSAWRLFRYILLPQGLANAWQPVVGQYLNLMKLSSLASGIGFAELTYqvrqIESYNAHA 210
Cdd:cd06261   91 IRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPG----PGTGLLLI 166

                        170       180
                 ....*....|....*....|...
gi 556426413 211 LEAFTLGTALYLLTGLVMGMVLV 233
Cdd:cd06261  167 FAILFPGDLGVAAAVALILLLLS 189
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 18-130 3.84e-08

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 49.84  E-value: 3.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413   18 ILSGFLTTLWVTLAGMLLASLLALLFMLLRLSGGRPGNAVVSSWVSLFRNTPLLVQLLFWYFaawnGLPQAFRDavnadh 97
Cdd:TIGR01726   5 LLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYF----GLPLIGIR------ 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 556426413   98 swsilpgnvwwfTPEFLCSAWGLGVFTSAFLIE 130
Cdd:TIGR01726  75 ------------LSPLTAAVIALTLFYGAYLAE 95
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 51-235 4.47e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 48.83  E-value: 4.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413   51 GRPGNAVVSSWVSLFRNTPLLVQLLFWYFAAWNGLPQafrdavnadhswsilpgnvWWFTPEFLCSAWGLGVFTSAFlie 130
Cdd:pfam00528  13 GRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILG-------------------HGILPAIILALLGWAGYARLI--- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  131 eVESGLRSVPAGQREAALAQGFSAWRLFRYILLPQGLANAWQPVVGQYLNLMKLSSLASGIG-FAELTYQVRQ-IESYNA 208
Cdd:pfam00528  71 -RRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGsWPGLGLLLIEaILGYDY 149

                         170       180
                  ....*....|....*....|....*..
gi 556426413  209 HALEAFTLGTALYLLTGLVMGMVLVRI 235
Cdd:pfam00528 150 PEIQGPVLAAALILLLLNLLVDILQRL 176
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 2-235 3.31e-47

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 156.00  E-value: 3.31e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413   2 PALDWQGVLtgQPLQWILSGFLTTLWVTLAGMLLASLLALLFMLLRLSGGRPGNAVVSSWVSLFRNTPLLVQLLFWYFaa 81
Cdd:COG0765    1 MFFDFSVLL--DYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYF-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  82 wnGLPQAFRDavnadhswsilpgnvwwfTPEFLCSAWGLGVFTSAFLIEEVESGLRSVPAGQREAALAQGFSAWRLFRYI 161
Cdd:COG0765   77 --GLPLLGID------------------LSPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRI 136

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556426413 162 LLPQGLANAWQPVVGQYLNLMKLSSLASGIGFAELTYQVRQIESYNAHALEAFTLGTALYLLTGLVMGMVLVRI 235
Cdd:COG0765  137 ILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRL 210
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 15-235 2.66e-22

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 91.69  E-value: 2.66e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  15 LQWILSGFLTTLWVTLAGMLLASLLALLFMLLRLSGGRPGNAVVSSWVSLFRNTPLLVQLLFWYFaawnGLPQaFrDAVN 94
Cdd:COG4160   10 LPLLLSGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYY----GLGQ-F-EWVR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  95 ADHSWsilpgnvWWFTPEFLCSAWGLGVFTSAFLIEEVESGLRSVPAGQREAALAQGFSAWRLFRYILLPQGLANAWQPv 174
Cdd:COG4160   84 ESWLW-------PLLRDPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPA- 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556426413 175 vgqYLN----LMKLSSLASGIGFAELTYQVRQIESYNAHALEAFTLGTALYlltgLVMGMVLVRI 235
Cdd:COG4160  156 ---YSNevilMLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIY----LVITFLLTRL 213
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 61-197 2.08e-20

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 89.05  E-value: 2.08e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  61 WVSLFRNTPLLVQLLFWYFAAWNGLPQAfRDAVN-------------------ADHSWSIL------------------- 102
Cdd:COG4597  131 YVEIFRNIPLLLQIFFWYFAVLEALPSP-RQSLSlfdgvflnnrglylpapvfEPGFGWVLaallaaivaafvlrrwarr 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413 103 -------PGNVWW--------------------------------------FTPEFLCSAWGLGVFTSAFLIEEVESGLR 137
Cdd:COG4597  210 rqeatgqRFPVWWislallvglpllaflllgaplsldypelkgfnfrggltLSPEFVALLLALSLYTAAFIAEIVRAGIQ 289

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413 138 SVPAGQREAALAQGFSAWRLFRYILLPQGLANAWQPVVGQYLNLMKLSSLASGIGFAELT 197
Cdd:COG4597  290 AVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNSSLAVAIGYPDLV 349
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 5-235 1.16e-17

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 78.94  E-value: 1.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413   5 DWQGVLTGQPLqwILSGFLTTLWVTLAGMLLASLLALLFMLLRLSGGRPGNAVVSSWVSLFRNTPLLVQLLFWYFAawng 84
Cdd:PRK09494   4 DWSAIWPAIPL--LLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFA---- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  85 LPQAFRDaVNADhswsilpgnvwwftpEFLCSAWGLGVFTSAFLIEEVESGLRSVPAGQREAALAQGFSAWRLFRYILLP 164
Cdd:PRK09494  78 LPMAFND-LRID---------------PFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGP 141

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556426413 165 QGLANAWQPVVGQYLNLMKLSSLASGIGFAELTYQVRQIESYNAHALEAFTLGTALYLLTGLVMGMVLVRI 235
Cdd:PRK09494 142 LALRRMLPPLGNQWIISIKDTSLFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRL 212
PRK15100 PRK15100
cystine ABC transporter permease;
61-223 1.28e-11

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 62.46  E-value: 1.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  61 WVSLFRNTPLLVQLLFWYFaawnGLPQAFRDavnadhswsilpgnvwwfTPEFLCSAWGLGVFTSAFLIEEVESGLRSVP 140
Cdd:PRK15100  58 YVSIFRGTPLIAQLFMIYY----GLPQFGIE------------------LDPIPAAMIGLSLNTAAYAAETLRAAISSID 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413 141 AGQREAALAQGFSAWRLFRYILLPQGLANAWQPVVGQYLNLMKLSSLASGIGFAELtyqVRQIESYNAHALEAFTLGTAL 220
Cdd:PRK15100 116 KGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPEL---FRQAQLITSRTLEVFTMYLAA 192


                 ...
gi 556426413 221 YLL 223
Cdd:PRK15100 193 SLI 195
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
52-235 2.04e-11

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 62.00  E-value: 2.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  52 RPGNAVVSSWVSLFRNTPLLVQLLFWYFAAWNG---LPQAFRDAVNADHSWSILPGNVWWFTPeFLCSAWGLGVFTSAFL 128
Cdd:PRK11123  41 RPVAWPGTALVTLLRGLPEILVVLFIYFGSSQLlltLSDGFTLNLGFVQIPVQMDIENFEVSP-FLCGVIALSLLYAAYA 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413 129 IEEVESGLRSVPAGQREAALAQGFSAWRLFRYILLPQGLANAWQPVVGQYLNLMKLSSLASGIGFAELtyqVRQIESYNA 208
Cdd:PRK11123 120 SQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQWLVLLKDTALVSLISVNDL---MLQTKSIAT 196

                        170       180       190
                 ....*....|....*....|....*....|
gi 556426413 209 HALEAFT---LGTALYLLTGLVMGMVLVRI 235
Cdd:PRK11123 197 RTQEPFTwyiIAAAIYLVITLISQYILKRI 226
PRK15069 PRK15069
histidine ABC transporter permease HisM;
64-228 4.28e-10

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 58.14  E-value: 4.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  64 LFRNTPLLVQLLFWY-----FAAWNG---LPQAFRDAVNadhswsilpgnvwwftpeflCSAWGLGVFTSAFLIEEVESG 135
Cdd:PRK15069  65 VFRGTPLYVQLLVFYtgmysLEIVRGtdlLDAFFRSGLN--------------------CTILAFTLNTCAYTTEIFAGA 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413 136 LRSVPAGQREAALAQGFSAWRLFRYILLPQGLANAWqPVVGQYLNLMKLS-SLASGIGFAELTYQVRQIESYNAHALEAF 214
Cdd:PRK15069 125 IRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRAL-PAYSNEVILMLHAtTLAFTATVPDILKIARDINSATYQPFQAF 203

                        170
                 ....*....|....
gi 556426413 215 TLGTALYLLTGLVM 228
Cdd:PRK15069 204 GIAAVLYLIISFVL 217
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 51-233 3.13e-09

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 54.98  E-value: 3.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  51 GRPGNAVVSSWVSLFRNTPLLVQLLFWYFAAWNGLPqafrdavnadhsWSILPGNVWWftpeflcSAWGLGVFTSAFLIE 130
Cdd:cd06261   30 RGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLG------------WGILPGLGLP-------ALILALLLIAPFARL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413 131 EVESGLRSVPAGQREAALAQGFSAWRLFRYILLPQGLANAWQPVVGQYLNLMKLSSLASGIGFAELTYqvrqIESYNAHA 210
Cdd:cd06261   91 IRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPG----PGTGLLLI 166

                        170       180
                 ....*....|....*....|...
gi 556426413 211 LEAFTLGTALYLLTGLVMGMVLV 233
Cdd:cd06261  167 FAILFPGDLGVAAAVALILLLLS 189
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 18-130 3.84e-08

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 49.84  E-value: 3.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413   18 ILSGFLTTLWVTLAGMLLASLLALLFMLLRLSGGRPGNAVVSSWVSLFRNTPLLVQLLFWYFaawnGLPQAFRDavnadh 97
Cdd:TIGR01726   5 LLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYF----GLPLIGIR------ 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 556426413   98 swsilpgnvwwfTPEFLCSAWGLGVFTSAFLIE 130
Cdd:TIGR01726  75 ------------LSPLTAAVIALTLFYGAYLAE 95
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 51-235 4.47e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 48.83  E-value: 4.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413   51 GRPGNAVVSSWVSLFRNTPLLVQLLFWYFAAWNGLPQafrdavnadhswsilpgnvWWFTPEFLCSAWGLGVFTSAFlie 130
Cdd:pfam00528  13 GRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILG-------------------HGILPAIILALLGWAGYARLI--- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  131 eVESGLRSVPAGQREAALAQGFSAWRLFRYILLPQGLANAWQPVVGQYLNLMKLSSLASGIG-FAELTYQVRQ-IESYNA 208
Cdd:pfam00528  71 -RRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGsWPGLGLLLIEaILGYDY 149

                         170       180
                  ....*....|....*....|....*..
gi 556426413  209 HALEAFTLGTALYLLTGLVMGMVLVRI 235
Cdd:pfam00528 150 PEIQGPVLAAALILLLLNLLVDILQRL 176
artM PRK11122
arginine ABC transporter permease ArtM;
57-226 5.54e-07

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 49.19  E-value: 5.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  57 VVSSWVSLFRNTPLLVQLLFWYFAawnglPQAFRDAVNADHSWSILpGNVWwftpefLCSAWGLGVFTSAFLIEEVESGL 136
Cdd:PRK11122  47 LVRGYITLFTGTPLLVQIFLIYYG-----PGQFPWLQEYPWLWHLL-SQPW------LCAMLALALNSAAYSTQLFYGAV 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413 137 RSVPAGQREAALAQGFSAWRLFRyILLPQGLANAwqpvVGQYLN----LMKLSSLASGIGFAELTYQVRQIESYNAHALe 212
Cdd:PRK11122 115 RAIPEGQWQSCAALGMSKKQTLR-ILLPYAFKRA----LSSYSNevvlVFKSTSLAYTITLMDVMGYSQLLYGRTYDVM- 188

                        170
                 ....*....|....*
gi 556426413 213 AFTLGTALYLL-TGL 226
Cdd:PRK11122 189 VFGAAGIIYLVvNGL 203
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
1-232 2.79e-06

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 47.13  E-value: 2.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413   1 MPALDWQGVLTGQPlqWILSGFLTTLWVTLAGMLLASLLALLFMLLRLSGGRPGNAVVSSWVSLFRNTPlLVQLLFWYFA 80
Cdd:PRK15107   1 MYEFDWSSIVPSLP--YLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIP-LVMVLLWFYL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413  81 AWNGLPQafrdavnadhswsilpgNVWWFTPEF---LCSAW-GLGVFTSAFLIEEVESGLRSVPAGQREAALAQGFSAWR 156
Cdd:PRK15107  78 IVPGFLQ-----------------NVLGLSPKTdirLISAMvAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQ 140

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556426413 157 LFRYILLPQGLANAWQPVVGQYLNLMKLSSLASGIGFAELTYQVRQIESYNAHALEAFTLGTALYLLTGLVMGMVL 232
Cdd:PRK15107 141 SMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLV 216
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
120-172 4.10e-04

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 40.55  E-value: 4.10e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 556426413 120 LGVFTSAFLIEEVESGLRSVPAGQREAALAQGFSAWRLFRYILLPQ-------GLANAWQ 172
Cdd:PRK15135 100 LGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAmmryalpGIGNNWQ 159
MetP COG2011
ABC-type methionine transport system, permease component [Amino acid transport and metabolism]; ...
 132-168 4.61e-03

ABC-type methionine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 441614  Cd Length: 220  Bit Score: 37.34  E-value: 4.61e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 556426413 132 VESGLRSVPAGQREAALAQGFSAWRLFRYILLPQGLA 168
Cdd:COG2011  111 VENALREVDPGVIEAAQAMGASPWQIIFKVLLPEALP 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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