MULTISPECIES: type II toxin-antitoxin system CcdA family antitoxin [Enterobacter]
Protein Classification
type II toxin-antitoxin system CcdA family antitoxin( domain architecture ID 14516)
type II toxin-antitoxin (TA) system CcdA family antitoxin similar to CcdA, the antitoxin component of the TA system that inhibits the post-segregational killing of plasmid-free cells, and that binds to and blocks the activity of the toxin CcdB
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| CcdA super family | cl02188 | Post-segregation antitoxin CcdA; This family consists of several Enterobacterial ... |
27-56 | 8.85e-03 | ||
Post-segregation antitoxin CcdA; This family consists of several Enterobacterial post-segregation antitoxin CcdA proteins. The F plasmid-carried bacterial toxin, the CcdB protein, is known to act on DNA gyrase in two different ways. CcdB poisons the gyrase-DNA complex, blocking the passage of polymerases and leading to double-strand breakage of the DNA. Alternatively, in cells that overexpress CcdB, the A subunit of DNA gyrase (GyrA) has been found as an inactive complex with CcdB. Both poisoning and inactivation can be prevented and reversed in the presence of the F plasmid-encoded antidote, the CcdA protein. The actual alignment was detected with superfamily member pfam07362: Pssm-ID: 470490 Cd Length: 71 Bit Score: 31.02 E-value: 8.85e-03
|
||||||
| Name | Accession | Description | Interval | E-value | ||
| CcdA | pfam07362 | Post-segregation antitoxin CcdA; This family consists of several Enterobacterial ... |
27-56 | 8.85e-03 | ||
Post-segregation antitoxin CcdA; This family consists of several Enterobacterial post-segregation antitoxin CcdA proteins. The F plasmid-carried bacterial toxin, the CcdB protein, is known to act on DNA gyrase in two different ways. CcdB poisons the gyrase-DNA complex, blocking the passage of polymerases and leading to double-strand breakage of the DNA. Alternatively, in cells that overexpress CcdB, the A subunit of DNA gyrase (GyrA) has been found as an inactive complex with CcdB. Both poisoning and inactivation can be prevented and reversed in the presence of the F plasmid-encoded antidote, the CcdA protein. Pssm-ID: 429428 Cd Length: 71 Bit Score: 31.02 E-value: 8.85e-03
|
||||||
| Name | Accession | Description | Interval | E-value | ||
| CcdA | pfam07362 | Post-segregation antitoxin CcdA; This family consists of several Enterobacterial ... |
27-56 | 8.85e-03 | ||
Post-segregation antitoxin CcdA; This family consists of several Enterobacterial post-segregation antitoxin CcdA proteins. The F plasmid-carried bacterial toxin, the CcdB protein, is known to act on DNA gyrase in two different ways. CcdB poisons the gyrase-DNA complex, blocking the passage of polymerases and leading to double-strand breakage of the DNA. Alternatively, in cells that overexpress CcdB, the A subunit of DNA gyrase (GyrA) has been found as an inactive complex with CcdB. Both poisoning and inactivation can be prevented and reversed in the presence of the F plasmid-encoded antidote, the CcdA protein. Pssm-ID: 429428 Cd Length: 71 Bit Score: 31.02 E-value: 8.85e-03
|
||||||
| Blast search parameters | ||||
|
