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Conserved domains on  [gi|556466064|ref|WP_023317829|]
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MULTISPECIES: type IV conjugative transfer system pilin TraA [Enterobacteriaceae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TraA super family cl11503
TraA; Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced ...
 13-100 1.52e-08

TraA; Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced in response to a peptide sex pheromone, cPD1, secreted from plasmid-free recipient cells. cPD1 is taken up by a pPD1 donor cell and binds to an intracellular receptor, TraA. Once a recipient cell acquires pPD1, it starts to produce an inhibitor of cPD1, termed iPD1, which functions as a TraA antagonist and blocks self-induction in donor cells. TraA transduces the signal of cPD1 to the mating response.


The actual alignment was detected with superfamily member TIGR02758:

Pssm-ID: 299752  Cd Length: 93  Bit Score: 47.88  E-value: 1.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556466064   13 RNLGAVAMAVMFVALMMTPSLhahAVDLFKNGKTTVKDTFGGSSTVIWILYVIEILSALFTYTKTKNL-AVFCGIAAVMV 91
Cdd:TIGR02758   6 LLLGVTAIAALSALAAFQPAL---AADLFAGGKATVKATAGKDSSVEMAMILAGLLVAAVMGFMTKNWfAALGGFAGGSI 82


                  ....*....
gi 556466064   92 FVNVVFGLI 100
Cdd:TIGR02758  83 FWNVGMALV 91
 
Name Accession Description Interval E-value
TraA_TIGR TIGR02758
type IV conjugative transfer system pilin TraA; TraA is the single structural subunit of the ...
 13-100 1.52e-08

type IV conjugative transfer system pilin TraA; TraA is the single structural subunit of the pilus found in type IV conjugative transfer systems. This family is generally found in gammaproteobacteria. The pilins show considerable heterogeneity among the different conjugative plasmit types. All of them however contain an N-terminal part which is cleaved off by a leader peptidase (LepB, or similar) to result in a 68-78 amino acid product. Pilins may be further processed by acetylation (in F-like systems by the TraX protein) or by cyclization (in P-like systems by the TraF protein).


Pssm-ID: 131805  Cd Length: 93  Bit Score: 47.88  E-value: 1.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556466064   13 RNLGAVAMAVMFVALMMTPSLhahAVDLFKNGKTTVKDTFGGSSTVIWILYVIEILSALFTYTKTKNL-AVFCGIAAVMV 91
Cdd:TIGR02758   6 LLLGVTAIAALSALAAFQPAL---AADLFAGGKATVKATAGKDSSVEMAMILAGLLVAAVMGFMTKNWfAALGGFAGGSI 82


                  ....*....
gi 556466064   92 FVNVVFGLI 100
Cdd:TIGR02758  83 FWNVGMALV 91
TraA pfam05513
TraA; Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced ...
 15-95 4.78e-05

TraA; Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced in response to a peptide sex pheromone, cPD1, secreted from plasmid-free recipient cells. cPD1 is taken up by a pPD1 donor cell and binds to an intracellular receptor, TraA. Once a recipient cell acquires pPD1, it starts to produce an inhibitor of cPD1, termed iPD1, which functions as a TraA antagonist and blocks self-induction in donor cells. TraA transduces the signal of cPD1 to the mating response.


Pssm-ID: 283228  Cd Length: 120  Bit Score: 39.27  E-value: 4.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556466064   15 LGAVAMAVMFVALMMTPSlhaHAVDLFKNGKTTVKDTFGGSSTVIWILYVIEILSALFTYTKTKNLAVFCGIAAVMVFVN 94
Cdd:pfam05513  38 IPAAALAAFFPDAAMAAG---GAQDLMASGDATVKATFGKDSSAVKWVILAEVLAGAIMYMMTKNVKFLAGFAIISTFIA 114


                  .
gi 556466064   95 V 95
Cdd:pfam05513 115 I 115
PRK13734 PRK13734
conjugal transfer pilin subunit TraA; Provisional
 15-95 7.13e-05

conjugal transfer pilin subunit TraA; Provisional


Pssm-ID: 237485  Cd Length: 120  Bit Score: 38.76  E-value: 7.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556466064  15 LGAVAMAVMFVALMMTPslhAHAVDLFKNGKTTVKDTFGGSSTVIWILYVIEILSALFTYTKTKNLAVFCGIAAVMVFVN 94
Cdd:PRK13734  36 IPVAVLMMFFPQLAMAG---AGGQDLMASGNTTVKATFGKDSSVVKWVVLAEVLVGAVMYMMTKNVKFLAGFAIISVFIA 112


                 .
gi 556466064  95 V 95
Cdd:PRK13734 113 V 113
 
Name Accession Description Interval E-value
TraA_TIGR TIGR02758
type IV conjugative transfer system pilin TraA; TraA is the single structural subunit of the ...
 13-100 1.52e-08

type IV conjugative transfer system pilin TraA; TraA is the single structural subunit of the pilus found in type IV conjugative transfer systems. This family is generally found in gammaproteobacteria. The pilins show considerable heterogeneity among the different conjugative plasmit types. All of them however contain an N-terminal part which is cleaved off by a leader peptidase (LepB, or similar) to result in a 68-78 amino acid product. Pilins may be further processed by acetylation (in F-like systems by the TraX protein) or by cyclization (in P-like systems by the TraF protein).


Pssm-ID: 131805  Cd Length: 93  Bit Score: 47.88  E-value: 1.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556466064   13 RNLGAVAMAVMFVALMMTPSLhahAVDLFKNGKTTVKDTFGGSSTVIWILYVIEILSALFTYTKTKNL-AVFCGIAAVMV 91
Cdd:TIGR02758   6 LLLGVTAIAALSALAAFQPAL---AADLFAGGKATVKATAGKDSSVEMAMILAGLLVAAVMGFMTKNWfAALGGFAGGSI 82


                  ....*....
gi 556466064   92 FVNVVFGLI 100
Cdd:TIGR02758  83 FWNVGMALV 91
TraA pfam05513
TraA; Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced ...
 15-95 4.78e-05

TraA; Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced in response to a peptide sex pheromone, cPD1, secreted from plasmid-free recipient cells. cPD1 is taken up by a pPD1 donor cell and binds to an intracellular receptor, TraA. Once a recipient cell acquires pPD1, it starts to produce an inhibitor of cPD1, termed iPD1, which functions as a TraA antagonist and blocks self-induction in donor cells. TraA transduces the signal of cPD1 to the mating response.


Pssm-ID: 283228  Cd Length: 120  Bit Score: 39.27  E-value: 4.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556466064   15 LGAVAMAVMFVALMMTPSlhaHAVDLFKNGKTTVKDTFGGSSTVIWILYVIEILSALFTYTKTKNLAVFCGIAAVMVFVN 94
Cdd:pfam05513  38 IPAAALAAFFPDAAMAAG---GAQDLMASGDATVKATFGKDSSAVKWVILAEVLAGAIMYMMTKNVKFLAGFAIISTFIA 114


                  .
gi 556466064   95 V 95
Cdd:pfam05513 115 I 115
PRK13734 PRK13734
conjugal transfer pilin subunit TraA; Provisional
 15-95 7.13e-05

conjugal transfer pilin subunit TraA; Provisional


Pssm-ID: 237485  Cd Length: 120  Bit Score: 38.76  E-value: 7.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556466064  15 LGAVAMAVMFVALMMTPslhAHAVDLFKNGKTTVKDTFGGSSTVIWILYVIEILSALFTYTKTKNLAVFCGIAAVMVFVN 94
Cdd:PRK13734  36 IPVAVLMMFFPQLAMAG---AGGQDLMASGNTTVKATFGKDSSVVKWVVLAEVLVGAVMYMMTKNVKFLAGFAIISVFIA 112


                 .
gi 556466064  95 V 95
Cdd:PRK13734 113 V 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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