|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15389 |
PRK15389 |
fumarate hydratase; Provisional |
2-537 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 237955 [Multi-domain] Cd Length: 536 Bit Score: 1229.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 2 SNKPFIYQNPFPLAHDDTEYYLLTKEHVSVAEFEGQEVLKVEPEALTLLAQQAFHDAAFMLRPSHQKQVAAILDDPEASQ 81
Cdd:PRK15389 1 SMPPFKYQDLFPLGKDDTEYRLLTSDGVSVAEFEGREILKVEPEALTLLAEEAFHDISHLLRPAHLQQLAKILDDPEASD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 82 NDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSQGVYNTYIEDNLRYSQNAALDMYKEVNTG 161
Cdd:PRK15389 81 NDKFVALDLLKNANIAAGGVLPMCQDTGTAIIMGKKGQRVWTGGDDEEALSRGVYDTYTELNLRYSQNAPLDMYEEKNTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 162 TNLPAQIDLYSVDGDEYKFLCMAKGGGSANKTYLYQETKALITPAKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAEAT 241
Cdd:PRK15389 161 TNLPAQIDIYATEGDEYKFLFMAKGGGSANKTFLYQETKALLNPDRLLAFLVEKMRTLGTAACPPYHLAIVIGGTSAEAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 242 LKTVKLASTRYYDALPTEGNEHGQAFRDVQLEQELLQEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPIGMGVSCSAD 321
Cdd:PRK15389 241 LKTVKLASAKYLDALPTEGNEHGHAFRDLELEQEVLKLTQKLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSAD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 322 RNIKAKINRDGIWIEKLEHNPGQYIPESLRQQGEGDVVSIDLNKPMNEILAQLSAHPVSTRLSLNGTIIVARDIAHAKLK 401
Cdd:PRK15389 321 RNIKAKITRDGIFLEQLETNPARYLPEVLREKLEGEVVKIDLNRPMAEILAELSKYPVKTRLSLTGTIIVARDIAHAKLK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 402 ELIDNGEELPQYVKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDLLQSHGASMIMLAKGNRSQQVTDACHKHGGFY 481
Cdd:PRK15389 401 ERLDAGEGLPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQAAGGSMVMLAKGNRSQQVTDACKKHGGFY 480
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 556473976 482 LGSIGGPAAVLAQNSIKSLECVAYPELGMEAIWKIEVENFPAFILVDDKGNDFFQQ 537
Cdd:PRK15389 481 LGSIGGPAARLAQDCIKKVEVLEYPELGMEAVWKIEVEDFPAFILVDDKGNDFFKE 536
|
|
| TtdA |
COG1951 |
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy ... |
41-341 |
3.61e-136 |
|
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441554 Cd Length: 289 Bit Score: 396.37 E-value: 3.61e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 41 KVEPEALTLLAQQAFHDAAFMLRPSHQKQVAAILDDpEASQNDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQR 120
Cdd:COG1951 3 EIDPEDLTEAVAELIIEASYYLPPDVLEALKEALEK-EESPNAKDVLAQILENAEIAAEGKLPICQDTGTAVVFVKIGQD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 121 VWTGGGDEAALSQGVYNTYIEDNLRYSQNAALDmykEVNTGTNLPAQIDLYSVDGDEYKFLCMAKGGGSANKTYLYqetk 200
Cdd:COG1951 82 VPIDGDLEEAINEGVRRAYKEGPLRKSVVDPLT---RKNTGDNTPAVIHIEIVPGDKLEITVAPKGGGSENKSALK---- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 201 aLITPAK----LKNYLVEKMRTLGTAACPPYHIAFVIGGTsAEATLKTVKLASTRYYDALPTEgnehgqaFRDVQLEQEL 276
Cdd:COG1951 155 -MLNPSEglegVKKFVLETVKEAGGNPCPPGIVGVGIGGT-AEKAAKLAKKALLRPLDERNPD-------PRLAELEEEL 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556473976 277 LQEAQNLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPIGMGVSCSADRNIKAKINRDGIWieKLEHN 341
Cdd:COG1951 226 LEAINKLGIGPQgLGGKTTALDVKIERAPRHIASLPVAVNINCWATRHATAVIDGDGPF--ELESP 289
|
|
| Fumerase_C |
pfam05683 |
Fumarase C-terminus; This family consists of the C terminal region of several bacterial ... |
332-537 |
6.00e-130 |
|
Fumarase C-terminus; This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth.
Pssm-ID: 461714 [Multi-domain] Cd Length: 204 Bit Score: 377.20 E-value: 6.00e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 332 GIWIEKLEHNPGQYIPESLRQQGEgDVVSIDLNKPmnEILAQLSAHPVSTRLSLNGTIIVARDIAHAKLKELIDNGEELP 411
Cdd:pfam05683 1 GSGPEQLEPPPLEYWPEWEEDDLA-EAVRVDLNRP--ETREELSKWPVGTRLLLSGTLLTGRDAAHKRIKEMLDKGEPLP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 412 QYVKD--HPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDLLQSHGASMIMLAKGNRSQQVTDACHKHGGFYLGSIGGpA 489
Cdd:pfam05683 78 EYVDLngRPIYYAGPVDTPGGEVVGSAGPTTATRMDKYVDDFLEKGGSMGMIGKGNRGPAVTEACKKHGGFYLGAIGG-A 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 556473976 490 AVLAQNSIKSLECVAYPELGMEAIWKIEVENFPAFILVDDKGNDFFQQ 537
Cdd:pfam05683 157 AYLAAKAIKKVEVVAFEELGMEAIWEFEVEDFPAFVAVDDKGNSFHKT 204
|
|
| ttdB_fumA_fumB |
TIGR00723 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S ... |
372-537 |
1.83e-80 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase beta chain and the C-terminal region of the class I fumarase (where the N-terminal region is homologous to the tartrate dehydratase alpha chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 129806 Cd Length: 168 Bit Score: 249.28 E-value: 1.83e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 372 AQLSAHPVSTRLSLNGTIIVARDIAHAKLKELIDNGEELPQYVKDHPIYYAGPAKTPEGYA-SGSLGPTTAGRMDSYVDL 450
Cdd:TIGR00723 1 EQILKLKVGDVVYLTGTIFTARDEAHARLLELIDEGKELPFDLNGSVIYHAGPIVTKNGEWeVVSVGPTTSARMNPFEPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 451 LQSHGASMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQnSIKSLECVAYPELGM-EAIWKIEVENF-PAFILVD 528
Cdd:TIGR00723 81 LLEKLGVMAIIGKGGMSKEVVEACRKYKAVYLAFPGGCAALLAQ-SVKKVEGVAWEDLGMpEAIWELEVEDFgPLIVAID 159
|
....*....
gi 556473976 529 DKGNDFFQQ 537
Cdd:TIGR00723 160 SHGNSIFQE 168
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15389 |
PRK15389 |
fumarate hydratase; Provisional |
2-537 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 237955 [Multi-domain] Cd Length: 536 Bit Score: 1229.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 2 SNKPFIYQNPFPLAHDDTEYYLLTKEHVSVAEFEGQEVLKVEPEALTLLAQQAFHDAAFMLRPSHQKQVAAILDDPEASQ 81
Cdd:PRK15389 1 SMPPFKYQDLFPLGKDDTEYRLLTSDGVSVAEFEGREILKVEPEALTLLAEEAFHDISHLLRPAHLQQLAKILDDPEASD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 82 NDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSQGVYNTYIEDNLRYSQNAALDMYKEVNTG 161
Cdd:PRK15389 81 NDKFVALDLLKNANIAAGGVLPMCQDTGTAIIMGKKGQRVWTGGDDEEALSRGVYDTYTELNLRYSQNAPLDMYEEKNTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 162 TNLPAQIDLYSVDGDEYKFLCMAKGGGSANKTYLYQETKALITPAKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAEAT 241
Cdd:PRK15389 161 TNLPAQIDIYATEGDEYKFLFMAKGGGSANKTFLYQETKALLNPDRLLAFLVEKMRTLGTAACPPYHLAIVIGGTSAEAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 242 LKTVKLASTRYYDALPTEGNEHGQAFRDVQLEQELLQEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPIGMGVSCSAD 321
Cdd:PRK15389 241 LKTVKLASAKYLDALPTEGNEHGHAFRDLELEQEVLKLTQKLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSAD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 322 RNIKAKINRDGIWIEKLEHNPGQYIPESLRQQGEGDVVSIDLNKPMNEILAQLSAHPVSTRLSLNGTIIVARDIAHAKLK 401
Cdd:PRK15389 321 RNIKAKITRDGIFLEQLETNPARYLPEVLREKLEGEVVKIDLNRPMAEILAELSKYPVKTRLSLTGTIIVARDIAHAKLK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 402 ELIDNGEELPQYVKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDLLQSHGASMIMLAKGNRSQQVTDACHKHGGFY 481
Cdd:PRK15389 401 ERLDAGEGLPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQAAGGSMVMLAKGNRSQQVTDACKKHGGFY 480
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 556473976 482 LGSIGGPAAVLAQNSIKSLECVAYPELGMEAIWKIEVENFPAFILVDDKGNDFFQQ 537
Cdd:PRK15389 481 LGSIGGPAARLAQDCIKKVEVLEYPELGMEAVWKIEVEDFPAFILVDDKGNDFFKE 536
|
|
| PRK15391 |
PRK15391 |
class I fumarate hydratase; |
1-548 |
0e+00 |
|
class I fumarate hydratase;
Pssm-ID: 185289 [Multi-domain] Cd Length: 548 Bit Score: 1224.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 1 MSNKPFIYQNPFPLAHDDTEYYLLTKEHVSVAEFEGQEVLKVEPEALTLLAQQAFHDAAFMLRPSHQKQVAAILDDPEAS 80
Cdd:PRK15391 1 MSNKPFIYQAPFPMGKDNTEYYLLTSDYVSVADFDGETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 81 QNDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSQGVYNTYIEDNLRYSQNAALDMYKEVNT 160
Cdd:PRK15391 81 ENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEEALSKGVYNTYIEDNLRYSQNAALDMYKEVNT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 161 GTNLPAQIDLYSVDGDEYKFLCMAKGGGSANKTYLYQETKALITPAKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAEA 240
Cdd:PRK15391 161 GTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAET 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 241 TLKTVKLASTRYYDALPTEGNEHGQAFRDVQLEQELLQEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPIGMGVSCSA 320
Cdd:PRK15391 241 NLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 321 DRNIKAKINRDGIWIEKLEHNPGQYIPESLRQQGEGDVVSIDLNKPMNEILAQLSAHPVSTRLSLNGTIIVARDIAHAKL 400
Cdd:PRK15391 321 DRNIKAKINREGIWIEKLEHNPGQYIPQELRQAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 401 KELIDNGEELPQYVKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDLLQSHGASMIMLAKGNRSQQVTDACHKHGGF 480
Cdd:PRK15391 401 KELIDAGKELPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGF 480
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556473976 481 YLGSIGGPAAVLAQNSIKSLECVAYPELGMEAIWKIEVENFPAFILVDDKGNDFFQQIQNQQCKGCSQ 548
Cdd:PRK15391 481 YLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVNKQCANCTK 548
|
|
| PRK15390 |
PRK15390 |
fumarate hydratase FumA; Provisional |
1-546 |
0e+00 |
|
fumarate hydratase FumA; Provisional
Pssm-ID: 185288 [Multi-domain] Cd Length: 548 Bit Score: 1103.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 1 MSNKPFIYQNPFPLAHDDTEYYLLTKEHVSVAEFEGQEVLKVEPEALTLLAQQAFHDAAFMLRPSHQKQVAAILDDPEAS 80
Cdd:PRK15390 1 MSNKPFHYQAPFPLKKDDTEYYLLTSEHVSVSEFEGQEILKVAPEALTLLARQAFHDASFMLRPAHQQQVADILRDPEAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 81 QNDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSQGVYNTYIEDNLRYSQNAALDMYKEVNT 160
Cdd:PRK15390 81 ENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDMYKEVNT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 161 GTNLPAQIDLYSVDGDEYKFLCMAKGGGSANKTYLYQETKALITPAKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAEA 240
Cdd:PRK15390 161 GTNLPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYQETKALLTPGKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAET 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 241 TLKTVKLASTRYYDALPTEGNEHGQAFRDVQLEQELLQEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPIGMGVSCSA 320
Cdd:PRK15390 241 NLKTVKLASAKYYDELPTEGNEHGQAFRDVELEKELLIEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 321 DRNIKAKINRDGIWIEKLEHNPGQYIPESLRQQGEGDVVSIDLNKPMNEILAQLSAHPVSTRLSLNGTIIVARDIAHAKL 400
Cdd:PRK15390 321 DRNIKAKINRQGIWIEKLEHNPGKYIPEELRKAGEGEAVRVDLNRPMKEILAQLSQYPVSTRLSLNGTIIVGRDIAHAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 401 KELIDNGEELPQYVKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDLLQSHGASMIMLAKGNRSQQVTDACHKHGGF 480
Cdd:PRK15390 401 KERMDNGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDACKKHGGF 480
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556473976 481 YLGSIGGPAAVLAQNSIKSLECVAYPELGMEAIWKIEVENFPAFILVDDKGNDFFQQIQNQQCKGC 546
Cdd:PRK15390 481 YLGSIGGPAAVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQLTQCTRC 546
|
|
| PTZ00226 |
PTZ00226 |
fumarate hydratase; Provisional |
2-537 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 240319 [Multi-domain] Cd Length: 570 Bit Score: 1003.41 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 2 SNKPFIYQNPFPLA--HDDTEYYLLTK--EHVSVAEF--EGQEVLKVEPEALTLLAQQAFHDAAFMLRPSHQKQVAAILD 75
Cdd:PTZ00226 25 VNPEFNFVPIFQPVdpHDTEEYRRLEDlsDYVEVVEVggGGKEILKVPPEALTKLTSYAFSDIQHFLRKSHLAQLRRILD 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 76 DPEASQNDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSQGVYNTYIEDNLRYSQNAALDMY 155
Cdd:PTZ00226 105 DPEASDNDRFVAMTLLKNACIAAGRVLPGCQDTGTAIVLGKRGELIWTGGEDEKALSKGVYNAYTNRNLRYSQLAPLDMF 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 156 KEVNTGTNLPAQIDLYSVDGDEYKFLCMAKGGGSANKTYLYQETKALITPAKLKNYLVEKMRTLGTAACPPYHIAFVIGG 235
Cdd:PTZ00226 185 DEKNTGCNLPAQIDLYATPGNEYEFLFIAKGGGSANKTFLYQQTKSLLNPKSLRKFLEEKIKTIGTSACPPYHLAVVIGG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 236 TSAEATLKTVKLASTRYYDALPTEGNEHGQAFRDVQLEQELLQEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPIGMG 315
Cdd:PTZ00226 265 LSAEMTLKTVKLASCRYYDSLPTSGDEYGRAFRDLEWEEIILEKTQNIGIGAQFGGKYFAHDVRVIRLPRHGASCPIGIG 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 316 VSCSADRNIKAKINRDGIWIEKLEHNPGQYIPE-SLRQQGEGDVVSIDLNKPMNEILAQLSAHPVSTRLSLNGTIIVARD 394
Cdd:PTZ00226 345 VSCSADRQILAKINKDGVYLEQLEHDPAQYLPDiTEDDLSKTPVVKIDLNQPMEEILKQLSKYPVKTRLSLTGTLIVARD 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 395 IAHAKLKELIDNGEELPQYVKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDLLQSHGASMIMLAKGNRSQQVTDAC 474
Cdd:PTZ00226 425 IAHAKIVEMLENGEPLPEYMKNHPIYYAGPAKTPDGYASGSFGPTTAGRMDSYVDLFMENGGSFITLAKGNRSKAVTNAC 504
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556473976 475 HKHGGFYLGSIGGPAAVLAQNSIKSLECVAYPELGMEAIWKIEVENFPAFILVDDKGNDFFQQ 537
Cdd:PTZ00226 505 KKYGGFYLGSIGGPAAILAKDNIKKVEVLDFPELGMEAVWKIEVENFPAFIVVDDKGNDFYSQ 567
|
|
| PLN00133 |
PLN00133 |
class I-fumerate hydratase; Provisional |
5-539 |
0e+00 |
|
class I-fumerate hydratase; Provisional
Pssm-ID: 215068 [Multi-domain] Cd Length: 576 Bit Score: 915.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 5 PFIYQNPF-PLAHDDTEYYLLTKEHVSVAEFEGQEVLKVEPEALTLLAQQAFHDAAFMLRPSHQKQVAAILDDPEASQND 83
Cdd:PLN00133 40 AFDYQPLFdSNAKKTVPWRKLTGDHVSVVEAAGEKYLKVAPEALTLLSDTAMRDVAHLLRPGHLQQLRNILDDPEASDND 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 84 KYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSQGVYNTYIEDNLRYSQNAALDMYKEVNTGTN 163
Cdd:PLN00133 120 RFVALELLKNANIAAGRVLPGCQDTGTAIVMGKRGQRVLTDGEDEEHLSRGVYDAYTDTNLRYSQVAPLDMFEEKNTGTN 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 164 LPAQIDLYSVDGDEYKFLCMAKGGGSANKTYLYQETKALITPAKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAEATLK 243
Cdd:PLN00133 200 LPAQIDLYAAKGDEYHFQFIAKGGGSANKTFLYQQTKALLNEGSLEAFLEEKIKTIGTSACPPYHLAIVIGGLSAEQNLK 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 244 TVKLASTRYYDALPTEGNEHGQAFRDVQLEQELLQEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPIGMGVSCSADRN 323
Cdd:PLN00133 280 TVKLASTRYYDTLPTSGNALGRAFRDLEWEEKILKMTRGLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSADRQ 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 324 IKAKINRDGIWIEKLEHNPGQYIPESLRQQGEGDVVSIDLNKPMNEILAQLSAHPVSTRLSLNGTIIVARDIAHAKLKEL 403
Cdd:PLN00133 360 ALGKITKDGVFLEALETDPSKYLPDVTEDSLSDDVVKVDLNRPMSEIRETLSAHPVRTRLSLTGTLVVARDIAHAKLLER 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 404 IDNGEELPQYVKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDLLQSHGASMIMLAKGNRSQQVTDACHKHGGFYLG 483
Cdd:PLN00133 440 LEAGEGLPQYAKDHIIYYAGPAKTPEGYASGSFGPTTAGRMDSYVDRFMAAGGSFVTLAKGNRSAQVTNACKKHGGFYLG 519
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 556473976 484 SIGGPAAVLAQNSIKSLECVAYPELGMEAIWKIEVENFPAFILVDDKGNDFFQQIQ 539
Cdd:PLN00133 520 SIGGPAAILAQNCIKKVEVLENPELGMEAVWKIEVEDFPAFIVVDDKGNDFFKKWQ 575
|
|
| PRK15392 |
PRK15392 |
class I fumarate hydratase; |
3-546 |
0e+00 |
|
class I fumarate hydratase;
Pssm-ID: 185290 [Multi-domain] Cd Length: 550 Bit Score: 895.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 3 NKPFIYQNPFPLAHDDTEYYLLTKEHVSVAEFEGQEVLKVEPEALTLLAQQAFHDAAFMLRPSHQKQVAAILDDPEASQN 82
Cdd:PRK15392 2 SKPFIWQEPFLQNKDGTEYTLISDQHITVTELDGEEVIKIAPEALTLLARQAFYEASFFLRSAHLQQVASILNDPQASSN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 83 DKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSQGVYNTYIEDNLRYSQNAALDMYKEVNTGT 162
Cdd:PRK15392 82 DKYVALQLLRNAEVSAKGVLPNCQDTGTATIVASKGQQIWTGGNDAEALSKGIYSTFQENNLRFSQNAPLDMYTEVNTQT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 163 NLPAQIDLYSVDGDEYKFLCMAKGGGSANKTYLYQETKALITPAKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAEATL 242
Cdd:PRK15392 162 NLPAQIDISAVAGDEYHFLCVNKGGGSANKAALYQETKSLLQPEKLTAFLIEKMKSLGTAACPPYHIAFVVGGLSADQTL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 243 KTVKLASTRYYDALPTEGNEHGQAFRDVQLEQELLQEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPIGMGVSCSADR 322
Cdd:PRK15392 242 KVAKLASTKYYDNLPTSGNEQGQAFRDIELEKVLLEASQQFGIGAQFGGKYFAHDIRVIRLPRHGGSCPIAMALSCSADR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 323 NIKAKINRDGIWIEKLEHNPGQYIPESLRQQGEGDVVSIDLNKPMNEILAQLSAHPVSTRLSLNGTIIVARDIAHAKLKE 402
Cdd:PRK15392 322 NIKAKINKHGIWLEKLEHNPGQYIPASLREENHAQHVQLDLNRPLRDVMQDLARLPVGTRVSLSGPIVVARDIAHAKIKA 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 403 LIDNGEELPQYVKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDLLQSHGASMIMLAKGNRSQQVTDACHKHGGFYL 482
Cdd:PRK15392 402 RLDSGEPMPEYLKHHIVYYAGPAKTPENMACGSLGPTTGGRMDGYVDTFQAAGGSLVMLSKGNRSQQVTDACHKHGGFNL 481
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556473976 483 GSIGGPAAVLAQNSIKSLECVAYPELGMEAIWKIEVENFPAFILVDDKGNDFFQQIQNQ-QCKGC 546
Cdd:PRK15392 482 GSIGGAAALLAQEYVKSLRCLEYPELGMEAVWMMEVENLPAFILVDDKGNNFFSQFEQQhRCASC 546
|
|
| TtdA |
COG1951 |
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy ... |
41-341 |
3.61e-136 |
|
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441554 Cd Length: 289 Bit Score: 396.37 E-value: 3.61e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 41 KVEPEALTLLAQQAFHDAAFMLRPSHQKQVAAILDDpEASQNDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQR 120
Cdd:COG1951 3 EIDPEDLTEAVAELIIEASYYLPPDVLEALKEALEK-EESPNAKDVLAQILENAEIAAEGKLPICQDTGTAVVFVKIGQD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 121 VWTGGGDEAALSQGVYNTYIEDNLRYSQNAALDmykEVNTGTNLPAQIDLYSVDGDEYKFLCMAKGGGSANKTYLYqetk 200
Cdd:COG1951 82 VPIDGDLEEAINEGVRRAYKEGPLRKSVVDPLT---RKNTGDNTPAVIHIEIVPGDKLEITVAPKGGGSENKSALK---- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 201 aLITPAK----LKNYLVEKMRTLGTAACPPYHIAFVIGGTsAEATLKTVKLASTRYYDALPTEgnehgqaFRDVQLEQEL 276
Cdd:COG1951 155 -MLNPSEglegVKKFVLETVKEAGGNPCPPGIVGVGIGGT-AEKAAKLAKKALLRPLDERNPD-------PRLAELEEEL 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556473976 277 LQEAQNLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPIGMGVSCSADRNIKAKINRDGIWieKLEHN 341
Cdd:COG1951 226 LEAINKLGIGPQgLGGKTTALDVKIERAPRHIASLPVAVNINCWATRHATAVIDGDGPF--ELESP 289
|
|
| Fumerase_C |
pfam05683 |
Fumarase C-terminus; This family consists of the C terminal region of several bacterial ... |
332-537 |
6.00e-130 |
|
Fumarase C-terminus; This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth.
Pssm-ID: 461714 [Multi-domain] Cd Length: 204 Bit Score: 377.20 E-value: 6.00e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 332 GIWIEKLEHNPGQYIPESLRQQGEgDVVSIDLNKPmnEILAQLSAHPVSTRLSLNGTIIVARDIAHAKLKELIDNGEELP 411
Cdd:pfam05683 1 GSGPEQLEPPPLEYWPEWEEDDLA-EAVRVDLNRP--ETREELSKWPVGTRLLLSGTLLTGRDAAHKRIKEMLDKGEPLP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 412 QYVKD--HPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDLLQSHGASMIMLAKGNRSQQVTDACHKHGGFYLGSIGGpA 489
Cdd:pfam05683 78 EYVDLngRPIYYAGPVDTPGGEVVGSAGPTTATRMDKYVDDFLEKGGSMGMIGKGNRGPAVTEACKKHGGFYLGAIGG-A 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 556473976 490 AVLAQNSIKSLECVAYPELGMEAIWKIEVENFPAFILVDDKGNDFFQQ 537
Cdd:pfam05683 157 AYLAAKAIKKVEVVAFEELGMEAIWEFEVEDFPAFVAVDDKGNSFHKT 204
|
|
| Fumerase |
pfam05681 |
Fumarate hydratase (Fumerase); This family consists of several bacterial fumarate hydratase ... |
48-324 |
5.64e-117 |
|
Fumarate hydratase (Fumerase); This family consists of several bacterial fumarate hydratase proteins FumA and FumB. Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth. Three fumarases, FumA, FumB, and FumC, have been reported in E. coli. fumA and fumB genes are homologous and encode products of identical sizes which form thermolabile dimers of Mr 120,000. FumA and FumB are class I enzymes and are members of the iron-dependent hydrolases, which include aconitase and malate hydratase. The active FumA contains a 4Fe-4S centre, and it can be inactivated upon oxidation to give a 3Fe-4S centre.
Pssm-ID: 461713 Cd Length: 267 Bit Score: 346.71 E-value: 5.64e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 48 TLLAQQAFHDAAFMLRPSHQKQVAAILDDpEASQNDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGD 127
Cdd:pfam05681 1 TEAVAELIIEASTYLPPDVLEALKKALEK-EESPNAKFVLEQILENAEIAAEEKLPICQDTGMAVVFVKIGQDVHIEGGD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 128 -EAALSQGVYNTYIEDNLRYSQNAalDMYKEVNTGTNLPAQIDLYSVDGDEYKFLCMAKGGGSANKTYLYqetkaLITPA 206
Cdd:pfam05681 80 lEEAINEGVRRAYTEGPLRKSVVA--DPLTRKNTGDNTPAVIHIEIVPGDELKITVAPKGGGSENMSALK-----MLNPA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 207 ----KLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAEATLKTVKlASTRyydALPTEG-NEHGQAfrdvqLEQELLQEAQ 281
Cdd:pfam05681 153 dgleGVKKFVLETVKEAGPNACPPYIVGVGIGGTFEKAALLAKK-ALLR---PLGTRNpDPRGAE-----LEEELLEAIN 223
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 556473976 282 NLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPIGMGVSCSADRNI 324
Cdd:pfam05681 224 KLGIGPQgLGGKTTALDVHIERAPTHIASLPVAVNVQCWADRHA 267
|
|
| FumA |
COG1838 |
Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy ... |
359-546 |
1.50e-98 |
|
Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441443 Cd Length: 190 Bit Score: 296.63 E-value: 1.50e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 359 VSIDLNKPMNEIlaQLSAHPVSTRLSLNGTIIVARDIAHAKLKELIDNGEELPQYVKDHPIYYAGPAKTPEGYASGSLGP 438
Cdd:COG1838 2 ATIRLNTPLTEE--DVRKLKAGDRVLLSGTIYTARDAAHKRLVELLDRGEPLPVDLKGQVIYYVGPAPAKPGYVIGSAGP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 439 TTAGRMDSYVDLLQSHGASMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQnSIKSLECVAYPELGMEAIWKIEV 518
Cdd:COG1838 80 TTSTRMDKYTPELLEELGLKGMIGKGGRSPEVIEAMKKHGAVYLAAVGGAAALLAK-AIKKVEVVAYEDLGPEAIWKLEV 158
|
170 180
....*....|....*....|....*...
gi 556473976 519 ENFPAFILVDDKGNDFFQQIQNQQCKGC 546
Cdd:COG1838 159 EDFPLIVAIDSKGNSLYEQGRAKARARL 186
|
|
| ttdB_fumA_fumB |
TIGR00723 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S ... |
372-537 |
1.83e-80 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase beta chain and the C-terminal region of the class I fumarase (where the N-terminal region is homologous to the tartrate dehydratase alpha chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 129806 Cd Length: 168 Bit Score: 249.28 E-value: 1.83e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 372 AQLSAHPVSTRLSLNGTIIVARDIAHAKLKELIDNGEELPQYVKDHPIYYAGPAKTPEGYA-SGSLGPTTAGRMDSYVDL 450
Cdd:TIGR00723 1 EQILKLKVGDVVYLTGTIFTARDEAHARLLELIDEGKELPFDLNGSVIYHAGPIVTKNGEWeVVSVGPTTSARMNPFEPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 451 LQSHGASMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQnSIKSLECVAYPELGM-EAIWKIEVENF-PAFILVD 528
Cdd:TIGR00723 81 LLEKLGVMAIIGKGGMSKEVVEACRKYKAVYLAFPGGCAALLAQ-SVKKVEGVAWEDLGMpEAIWELEVEDFgPLIVAID 159
|
....*....
gi 556473976 529 DKGNDFFQQ 537
Cdd:TIGR00723 160 SHGNSIFQE 168
|
|
| PRK06842 |
PRK06842 |
Fe-S-containing hydro-lyase; |
385-536 |
3.80e-46 |
|
Fe-S-containing hydro-lyase;
Pssm-ID: 180724 [Multi-domain] Cd Length: 185 Bit Score: 159.95 E-value: 3.80e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 385 LNGTIIVARDIAHAKLKELIDNGEELPQYVKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDLLQSHGAsMIMLAKG 464
Cdd:PRK06842 25 ISGYIYTARDAAHKRLIELLDKGEELPIDIKDQIIYYVGPSPAKPGKVIGSAGPTTSYRMDAYAPRLLDIGL-KGMIGKG 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556473976 465 NRSQQVTDACHKHGGFYLGSIGGPAAVLAQnSIKSLECVAYPELGMEAIWKIEVENFPAFILVDDKGNDFFQ 536
Cdd:PRK06842 104 ARSDEVIESIKKNKAVYFGAIGGAAALIAK-SIKKSEVIAYEDLGAEAIRKLEVKDFPVVVIIDSEGNNLYE 174
|
|
| PRK06246 |
PRK06246 |
fumarate hydratase; Provisional |
78-328 |
9.67e-38 |
|
fumarate hydratase; Provisional
Pssm-ID: 180486 Cd Length: 280 Bit Score: 140.30 E-value: 9.67e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 78 EASQNDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGD-EAALSQGVYNTYIEDNLRysQNAALDMYK 156
Cdd:PRK06246 39 EESPIGKEILKAILENAEIAKEEQVPLCQDTGMAVVFVEIGQDVHIEGGDlEDAINEGVRKGYEEGYLR--KSVVADPLT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 157 EVNTGTNLPAQIDLYSVDGDEYKFLCMAKGGGSANKTYLyqetkALITPA----KLKNYLVEKMRTLGTAACPPYHIAFV 232
Cdd:PRK06246 117 RKNTGDNTPAVIHTEIVPGDKLKITVAPKGGGSENMSAL-----KMLKPAdgleGIKKFVLETVKEAGGNPCPPIIVGVG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 233 IGGTSAEATlktvKLASTryydALPTEGNEHGQAFRDVQLEQELLQEAQNLGLGAQ-FGGKYFAHDIRVIRLPRHGASCP 311
Cdd:PRK06246 192 IGGTFDKAA----KLAKK----ALLRPIGERNPDPEIAALEEELLEEINKLGIGPMgLGGKTTALDVKIETYPCHIASLP 263
|
250
....*....|....*..
gi 556473976 312 IGMGVSCSADRNIKAKI 328
Cdd:PRK06246 264 VAVNIQCHAARHAEVVL 280
|
|
| ttdA_fumA_fumB |
TIGR00722 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region; A number of Fe-S ... |
76-328 |
8.85e-34 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase alpha chain and the N-terminal region of the class I fumarase (where the C-terminal region is homologous to the tartrate dehydratase beta chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 273234 Cd Length: 273 Bit Score: 129.12 E-value: 8.85e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 76 DPEASQNDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSQGVYNTYIEDNLRYSqnaALDMY 155
Cdd:TIGR00722 29 DREESEIAKINLEAILDNIEIAEKLGVPVCQDTGVPIFFVKVGSRFVLIGKLYEAIKQGVEEATEEVPLRPN---AVHPL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 156 KEVNTGTNL---PAQIDLYSVDGDEYKFLCMAKGGGSANKTYLyqetkALITPA----KLKNYLVEKMRTLGTAACPPYH 228
Cdd:TIGR00722 106 TRENTGDNTglgVPQIHVEIVPGDELEIVVFPKGAGSENPSAL-----KMLKPSdgieGVKKFVLETVKNAGGKPCPPII 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 229 IAFVIGGTsAEATLKTVKLASTRYYdalpteGNEHGQAfRDVQLEQELLQEAQNLGLGAQ-FGGKYFAHDIRVIRLPRHG 307
Cdd:TIGR00722 181 VGVGIGGS-FETAAKLAKKALLRPI------GERHPNP-KIAKLELELLEEINSLGIGPMgLGGKTTALDVKIESAHCHT 252
|
250 260
....*....|....*....|.
gi 556473976 308 ASCPIGMGVSCSADRNIKAKI 328
Cdd:TIGR00722 253 ASLPVAVNIQCWAHRRATLVV 273
|
|
| PRK06043 |
PRK06043 |
fumarate hydratase; Provisional |
385-539 |
3.43e-28 |
|
fumarate hydratase; Provisional
Pssm-ID: 180366 Cd Length: 192 Bit Score: 111.39 E-value: 3.43e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 385 LNGTIIVARDIAHAKLKELIDNGEELPQYVKDHPIYYAGP--AKTPEGYASGSLGPTTAGRMDSYV-DLLQSHGAsMIML 461
Cdd:PRK06043 25 ISGEILTARDEAHARILEMKEKGKELPFSLEGAVIYHCGPlmKKTDEGWKVVSAGPTTSARMSKMTpKLLEKVEV-RAII 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 462 AKGNRsQQVTDAChKHGGFYLGSIGGPAAvLAQNSIKSLECVAYPELGM-EAIWKIEVENF-PAFILVDDKGNDFFQQIQ 539
Cdd:PRK06043 104 GKGGM-KNVADAL-KGKCVYLAYTGGCAA-LAAESIKRVKAVHWLDLGMpEAVWVLEVEEFgPLIVGIDAKGNDLYSEVR 180
|
|
| PRK08228 |
PRK08228 |
L(+)-tartrate dehydratase subunit beta; Validated |
385-537 |
7.80e-24 |
|
L(+)-tartrate dehydratase subunit beta; Validated
Pssm-ID: 236192 Cd Length: 204 Bit Score: 99.36 E-value: 7.80e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 385 LNGTIIVARDIAHaklKELIDNGEELPQYVKDHPIYYAGP----AKTPEGYASGSLGPTTAGRMDSY-VDLLQSHGASMI 459
Cdd:PRK08228 26 LTGTLVTCRDVAH---RRLIELGRELPVDLNGGAIFHAGPivrpKKNDDKFEMVSVGPTTSMRMEKFeKEFIEQTGVKLI 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 460 mLAKGNRSQQVTDACHKHGGFYLGSIGGpAAVLAQNSIKSLECVAYPELGM-EAIWKIEVENF-PAFILVDDKGNDFFQQ 537
Cdd:PRK08228 103 -VGKGGMGPGTEEGCQEFKALHCVFPAG-CAVLAATQVEEIEDAQWRDLGMpETLWVCRVKEFgPLIVSIDTHGNNLFEE 180
|
|
| PRK08395 |
PRK08395 |
fumarate hydratase; Provisional |
379-536 |
1.76e-16 |
|
fumarate hydratase; Provisional
Pssm-ID: 169425 Cd Length: 162 Bit Score: 77.16 E-value: 1.76e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 379 VSTRLSLNGTIIVARDIAHAKLKElidngEELPQYVKDHPIYYAGPAKTPEGYASGslGPTTAGRMDSYVDLLQSHGASM 458
Cdd:PRK08395 17 AGDVVYLSGIIYTARDLAHRRFLS-----EGFPFNPEGAVIYHCGPLVKNKKIVSA--GPTTSARMNKYLDFLFSLGVRG 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556473976 459 IMLAKGNRSQQVtdachKHGGFYLGSIGGpAAVLAQNSIKSLECVAYPELGM-EAIWKIEVENFPAFILVDDKGNDFFQ 536
Cdd:PRK08395 90 IIGKGGMNAEPF-----KGRAVYFAFPGG-AGSLAAKSIKRVRDVYWEDLGMpDAVWELEVEDFPLLVAIDSKGRSLYR 162
|
|
| PRK08230 |
PRK08230 |
tartrate dehydratase subunit alpha; Validated |
74-331 |
4.23e-11 |
|
tartrate dehydratase subunit alpha; Validated
Pssm-ID: 181309 Cd Length: 299 Bit Score: 63.96 E-value: 4.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 74 LDDPEASQNDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSQGVYNTYIEDNLRYSqnaALD 153
Cdd:PRK08230 36 LKDAETSPLAKIIYDTMFENQQLAIDLNRPSCQDTGVIQFFVKVGARFPLLGELESILKEAVEEATVKAPLRHN---AVE 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 154 MYKEVNTGTNLPAQI---------DLYSVDGDEYkflcMAKGGGSanktyLYQETKALItPAK----LKNYLVEKMRTLG 220
Cdd:PRK08230 113 TFDEYNTGKNTGSGVpwvfweivpDSDDAEIEVY----MAGGGCT-----LPGRAKVLM-PGEgyegVVKFVFDVITSYG 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473976 221 TAACPPYHIAFVIgGTSAEATLKTVKLASTRyydalPTeGNEHGQAfRDVQLEQeLLQEAQN-LGLGAQ-FGGKYFAHDI 298
Cdd:PRK08230 183 VNACPPLLVGVGI-ATSVETAAVLSKKAILR-----PI-GSRNPNP-RAAELEK-RLEEGLNrIGLGPQgLTGNSSVMGV 253
|
250 260 270
....*....|....*....|....*....|...
gi 556473976 299 RVIRLPRHGASCPIGMGVSCSADRNIKAKINRD 331
Cdd:PRK08230 254 NIESAARHPSTIGVAVSTGCWAHRRGTIVFDAD 286
|
|
| |
