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Conserved domains on  [gi|556473977|ref|WP_023325582|]
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MULTISPECIES: LysR family transcriptional regulator [Enterobacter]

Protein Classification

LysR family transcriptional regulator( domain architecture ID 11426483)

LysR family transcriptional regulator containing an N-terminal HTH (helix-turn-helix) DNA-binding domain and a C-terminal substrate binding domain, which is structurally homologous to the type 2 periplasmic-binding (PBP2) fold proteins

CATH:  3.40.190.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  19047729|8257110|15808743
SCOP:  4000316

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
7-243 6.42e-26

DNA-binding transcriptional regulator, LysR family [Transcription];


:

Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 103.02  E-value: 6.42e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977   7 SFAQLEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQRQAHLLMRQVKAFEAF 86
Cdd:COG0583    2 DLRQLRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRGLRLTEAGERLLERARRILAELEEAEAE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  87 AREVPHGATQDLTLVYDPFTPRAFLHGVIAEMAVR--KIRLSLICASRDESERLLANNDADLAICqaRNRSVGNDMEWRA 164
Cdd:COG0583   82 LRALRGGPRGTLRIGAPPSLARYLLPPLLARFRARhpGVRLELREGNSDRLVDALLEGELDLAIR--LGPPPDPGLVARP 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556473977 165 LGAIEMDFYAASGLfadsasplslldlslvpqlvmhpasdePVARRLQISGHTlftnepEMLRGLLERGCGWGFLPTHF 243
Cdd:COG0583  160 LGEERLVLVASPDH---------------------------PLARRAPLVNSL------EALLAAVAAGLGIALLPRFL 205
 
Name Accession Description Interval E-value
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
7-243 6.42e-26

DNA-binding transcriptional regulator, LysR family [Transcription];


Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 103.02  E-value: 6.42e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977   7 SFAQLEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQRQAHLLMRQVKAFEAF 86
Cdd:COG0583    2 DLRQLRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRGLRLTEAGERLLERARRILAELEEAEAE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  87 AREVPHGATQDLTLVYDPFTPRAFLHGVIAEMAVR--KIRLSLICASRDESERLLANNDADLAICqaRNRSVGNDMEWRA 164
Cdd:COG0583   82 LRALRGGPRGTLRIGAPPSLARYLLPPLLARFRARhpGVRLELREGNSDRLVDALLEGELDLAIR--LGPPPDPGLVARP 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556473977 165 LGAIEMDFYAASGLfadsasplslldlslvpqlvmhpasdePVARRLQISGHTlftnepEMLRGLLERGCGWGFLPTHF 243
Cdd:COG0583  160 LGEERLVLVASPDH---------------------------PLARRAPLVNSL------EALLAAVAAGLGIALLPRFL 205
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
8-67 3.61e-12

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 60.48  E-value: 3.61e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977    8 FAQLEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGE 67
Cdd:pfam00126   1 LRQLRLFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFERTTRGVRLTEAGE 60
LysR_Sec_metab NF040786
selenium metabolism-associated LysR family transcriptional regulator; LysR family ...
 8-89 6.14e-09

selenium metabolism-associated LysR family transcriptional regulator; LysR family transcriptional regulators regularly appear encoded adjacent to selenecysteine incorporation proteins such as SelB. This model represents one especially well-conserved subgroup of such transcription factors from species such as Merdimonas faecis, Sellimonas intestinalis, Syntrophotalea acetylenica, and Hydrogenivirga caldilitoris. Seed alignment members were selected by proximity to selB, but not all family members are expected to have similar genomic locations.


Pssm-ID: 468737 [Multi-domain]  Cd Length: 298  Bit Score: 56.09  E-value: 6.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977   8 FAQLEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQRQA-HLLMRQVKAFEAF 86
Cdd:NF040786   3 LKQLEAFVNVAEYKSFSKAAKKLFLTQPTISAHISSLEKELGVRLFVRNTKEVSLTEDGKLLYEYAkEMLDLWEKLEEEF 82


                 ...
gi 556473977  87 ARE 89
Cdd:NF040786  83 DRY 85
PRK10094 PRK10094
HTH-type transcriptional activator AllS;
11-175 1.63e-08

HTH-type transcriptional activator AllS;


Pssm-ID: 182237 [Multi-domain]  Cd Length: 308  Bit Score: 54.81  E-value: 1.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  11 LEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQRQAHLLMRQVKAFEAFAREV 90
Cdd:PRK10094   7 LRTFIAVAETGSFSKAAERLCKTTATISYRIKLLEENTGVALFFRTTRSVTLTAAGEHLLSQARDWLSWLESMPSELQQV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  91 PHGATQDLTLV-----YDPFTPR---AFLHGVIAEMAVRkIRLSLICASRDEserlLANNDADLAICQARNRSVGNDMEW 162
Cdd:PRK10094  87 NDGVERQVNIVinnllYNPQAVAqllAWLNERYPFTQFH-ISRQIYMGVWDS----LLYEGFSLAIGVTGTEALANTFSL 161

                        170
                 ....*....|...
gi 556473977 163 RALGAIEMDFYAA 175
Cdd:PRK10094 162 DPLGSVQWRFVMA 174
 
Name Accession Description Interval E-value
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
7-243 6.42e-26

DNA-binding transcriptional regulator, LysR family [Transcription];


Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 103.02  E-value: 6.42e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977   7 SFAQLEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQRQAHLLMRQVKAFEAF 86
Cdd:COG0583    2 DLRQLRAFVAVAEEGSFTAAAERLGVSQPAVSRQIRRLEEELGVPLFERTGRGLRLTEAGERLLERARRILAELEEAEAE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  87 AREVPHGATQDLTLVYDPFTPRAFLHGVIAEMAVR--KIRLSLICASRDESERLLANNDADLAICqaRNRSVGNDMEWRA 164
Cdd:COG0583   82 LRALRGGPRGTLRIGAPPSLARYLLPPLLARFRARhpGVRLELREGNSDRLVDALLEGELDLAIR--LGPPPDPGLVARP 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556473977 165 LGAIEMDFYAASGLfadsasplslldlslvpqlvmhpasdePVARRLQISGHTlftnepEMLRGLLERGCGWGFLPTHF 243
Cdd:COG0583  160 LGEERLVLVASPDH---------------------------PLARRAPLVNSL------EALLAAVAAGLGIALLPRFL 205
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
8-67 3.61e-12

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 60.48  E-value: 3.61e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977    8 FAQLEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGE 67
Cdd:pfam00126   1 LRQLRLFVAVAETGSFTAAAERLGLSQPAVSRQIKRLEEELGVPLFERTTRGVRLTEAGE 60
LysR_Sec_metab NF040786
selenium metabolism-associated LysR family transcriptional regulator; LysR family ...
 8-89 6.14e-09

selenium metabolism-associated LysR family transcriptional regulator; LysR family transcriptional regulators regularly appear encoded adjacent to selenecysteine incorporation proteins such as SelB. This model represents one especially well-conserved subgroup of such transcription factors from species such as Merdimonas faecis, Sellimonas intestinalis, Syntrophotalea acetylenica, and Hydrogenivirga caldilitoris. Seed alignment members were selected by proximity to selB, but not all family members are expected to have similar genomic locations.


Pssm-ID: 468737 [Multi-domain]  Cd Length: 298  Bit Score: 56.09  E-value: 6.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977   8 FAQLEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQRQA-HLLMRQVKAFEAF 86
Cdd:NF040786   3 LKQLEAFVNVAEYKSFSKAAKKLFLTQPTISAHISSLEKELGVRLFVRNTKEVSLTEDGKLLYEYAkEMLDLWEKLEEEF 82


                 ...
gi 556473977  87 ARE 89
Cdd:NF040786  83 DRY 85
PRK10094 PRK10094
HTH-type transcriptional activator AllS;
11-175 1.63e-08

HTH-type transcriptional activator AllS;


Pssm-ID: 182237 [Multi-domain]  Cd Length: 308  Bit Score: 54.81  E-value: 1.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  11 LEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQRQAHLLMRQVKAFEAFAREV 90
Cdd:PRK10094   7 LRTFIAVAETGSFSKAAERLCKTTATISYRIKLLEENTGVALFFRTTRSVTLTAAGEHLLSQARDWLSWLESMPSELQQV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  91 PHGATQDLTLV-----YDPFTPR---AFLHGVIAEMAVRkIRLSLICASRDEserlLANNDADLAICQARNRSVGNDMEW 162
Cdd:PRK10094  87 NDGVERQVNIVinnllYNPQAVAqllAWLNERYPFTQFH-ISRQIYMGVWDS----LLYEGFSLAIGVTGTEALANTFSL 161

                        170
                 ....*....|...
gi 556473977 163 RALGAIEMDFYAA 175
Cdd:PRK10094 162 DPLGSVQWRFVMA 174
PRK11242 PRK11242
DNA-binding transcriptional regulator CynR; Provisional
 14-148 7.10e-08

DNA-binding transcriptional regulator CynR; Provisional


Pssm-ID: 183051 [Multi-domain]  Cd Length: 296  Bit Score: 52.65  E-value: 7.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  14 FTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQRQAHLLMRQVKAfeafAREVPHG 93
Cdd:PRK11242   9 FLAVAEHGNFTRAAEALHVSQPTLSQQIRQLEESLGVQLFDRSGRTVRLTDAGEVYLRYARRALQDLEA----GRRAIHD 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556473977  94 AtQDLT-----LVYDP-FTprAFLHG-VIAEMAVR--KIRLSLICASRDESERLLANNDADLAI 148
Cdd:PRK11242  85 V-ADLSrgslrLAMTPtFT--AYLIGpLIDAFHARypGITLTIREMSQERIEALLADDELDVGI 145
PRK13348 PRK13348
HTH-type transcriptional regulator ArgP;
9-85 1.88e-07

HTH-type transcriptional regulator ArgP;


Pssm-ID: 237357 [Multi-domain]  Cd Length: 294  Bit Score: 51.51  E-value: 1.88e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556473977   9 AQLEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRdGRTLRLTPEGEQLQRqaHLlmRQVKAFEA 85
Cdd:PRK13348   5 KQLEALAAVVETGSFERAARRLHVTPSAVSQRIKALEESLGQPLLVR-GRPCRPTPAGQRLLR--HL--RQVALLEA 76
PRK09906 PRK09906
DNA-binding transcriptional regulator HcaR; Provisional
 11-147 2.94e-07

DNA-binding transcriptional regulator HcaR; Provisional


Pssm-ID: 182137 [Multi-domain]  Cd Length: 296  Bit Score: 50.92  E-value: 2.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  11 LEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQRQAHLLMRQVKAFEAFAREV 90
Cdd:PRK09906   6 LRYFVAVAEELNFTKAAEKLHTAQPSLSQQIKDLENCVGVPLLVRDKRKVALTAAGEVFLQDARAILEQAEKAKLRARKI 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 556473977  91 PHgATQDLTLVYDPFTPRAFLHGVIAEMAVRK--IRLSLICASRDESERLLANNDADLA 147
Cdd:PRK09906  86 VQ-EDRQLTIGFVPSAEVNLLPKVLPMFRLRHpdTLIELVSLITTQQEEKLRRGELDVG 143
PRK15421 PRK15421
HTH-type transcriptional regulator MetR;
10-85 4.56e-07

HTH-type transcriptional regulator MetR;


Pssm-ID: 185319 [Multi-domain]  Cd Length: 317  Bit Score: 50.40  E-value: 4.56e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556473977  10 QLEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQRQAHLLMRQV-KAFEA 85
Cdd:PRK15421   6 HLKTLQALRNCGSLAAAAATLHQTQSALSHQFSDLEQRLGFRLFVRKSQPLRFTPQGEILLQLANQVLPQIsQALQA 82
PRK12680 PRK12680
LysR family transcriptional regulator;
7-148 4.10e-06

LysR family transcriptional regulator;


Pssm-ID: 183677 [Multi-domain]  Cd Length: 327  Bit Score: 47.69  E-value: 4.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977   7 SFAQLEAFTAVAE-NGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLR-LTPEGEQLQRQAHLLMRQVKAFE 84
Cdd:PRK12680   2 TLTQLRYLVAIADaELNITLAAARVHATQPGLSKQLKQLEDELGFLLFVRKGRSLEsVTPAGVEVIERARAVLSEANNIR 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 556473977  85 AFAREVPHGATQDLTLVYDPFTPRAFLHGVIAEM--AVRKIRLSLICASRDESERLLANNDADLAI 148
Cdd:PRK12680  82 TYAANQRRESQGQLTLTTTHTQARFVLPPAVAQIkqAYPQVSVHLQQAAESAALDLLGQGDADIAI 147
PRK09791 PRK09791
LysR family transcriptional regulator;
8-82 4.93e-06

LysR family transcriptional regulator;


Pssm-ID: 182077 [Multi-domain]  Cd Length: 302  Bit Score: 47.06  E-value: 4.93e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556473977   8 FAQLEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQRQAHLLMRQVKA 82
Cdd:PRK09791   7 IHQIRAFVEVARQGSIRGASRMLNMSQPALTKSIQELEEGLAAQLFFRRSKGVTLTDAGESFYQHASLILEELRA 81
PRK12682 PRK12682
transcriptional regulator CysB-like protein; Reviewed
 16-148 8.93e-06

transcriptional regulator CysB-like protein; Reviewed


Pssm-ID: 183679 [Multi-domain]  Cd Length: 309  Bit Score: 46.52  E-value: 8.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  16 AVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDG-RTLRLTPEGEQLQRQAHLLMRQVKAFEAFAREVPHGA 94
Cdd:PRK12682  12 AVRRNLNLTEAAKALHTSQPGVSKAIIELEEELGIEIFIRHGkRLKGLTEPGKAVLDVIERILREVGNIKRIGDDFSNQD 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 556473977  95 TQDLTLVYDPFTPRAFLHGVIAEMAVR--KIRLSLICASRDESERLLANNDADLAI 148
Cdd:PRK12682  92 SGTLTIATTHTQARYVLPRVVAAFRKRypKVNLSLHQGSPDEIARMVISGEADIGI 147
PRK11074 PRK11074
putative DNA-binding transcriptional regulator; Provisional
 11-103 1.49e-05

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 182948 [Multi-domain]  Cd Length: 300  Bit Score: 45.70  E-value: 1.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  11 LEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQRQAHLLMRQVKAFEAFAREV 90
Cdd:PRK11074   7 LEVVDAVARTGSFSAAAQELHRVPSAVSYTVRQLEEWLAVPLFERRHRDVELTPAGEWFVKEARSVIKKMQETRRQCQQV 86

                         90
                 ....*....|...
gi 556473977  91 PHGATQDLTLVYD 103
Cdd:PRK11074  87 ANGWRGQLSIAVD 99
PRK11716 PRK11716
HTH-type transcriptional activator IlvY;
44-79 3.93e-05

HTH-type transcriptional activator IlvY;


Pssm-ID: 236961 [Multi-domain]  Cd Length: 269  Bit Score: 44.04  E-value: 3.93e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 556473977  44 LEDGLGYALFIRDGRTLRLTPEGEQLQRQAHLLMRQ 79
Cdd:PRK11716  15 LEEELGQPLFVRDNRSVTLTEAGEELRPFAQQTLLQ 50
rbcR CHL00180
LysR transcriptional regulator; Provisional
 4-73 5.19e-05

LysR transcriptional regulator; Provisional


Pssm-ID: 177082 [Multi-domain]  Cd Length: 305  Bit Score: 43.86  E-value: 5.19e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977   4 LIYSFAQLEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQRQA 73
Cdd:CHL00180   3 LPFTLDQLRILKAIATEGSFKKAAESLYISQPAVSLQIKNLEKQLNIPLFDRSKNKASLTEAGELLLRYG 72
LysR_substrate pfam03466
LysR substrate binding domain; The structure of this domain is known and is similar to the ...
 98-242 5.67e-05

LysR substrate binding domain; The structure of this domain is known and is similar to the periplasmic binding proteins. This domain binds a variety of ligands that caries in size and structure, such as amino acids, sugar phosphates, organic acids, metal cations, flavonoids, C6-ring carboxylic acids, H2O2, HOCl, homocysteine, NADPH, ATP, sulphate, muropeptides, acetate, salicylate, citrate, phenol- and quinolone derivatives, acetylserines, fatty acid CoA, shikimate, chorismate, homocysteine, indole-3-acetic acid, Na(I), c-di-GMP, ppGpp and hydrogen peroxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460931 [Multi-domain]  Cd Length: 205  Bit Score: 43.43  E-value: 5.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977   98 LTLVYDPFTPRAFLHGVIAEMAVR--KIRLSLICASRDESERLLANNDADLAIcqARNRSVGNDMEWRALGAIEMDFYAA 175
Cdd:pfam03466   4 LRIGAPPTLASYLLPPLLARFRERypDVELELTEGNSEELLDLLLEGELDLAI--RRGPPDDPGLEARPLGEEPLVLVAP 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556473977  176 SGLFADSASPLSLLDLSLVPQLVMHPASD--EPVARRLQISGHT----LFTNEPEMLRGLLERGCGWGFLPTH 242
Cdd:pfam03466  82 PDHPLARGEPVSLEDLADEPLILLPPGSGlrDLLDRALRAAGLRprvvLEVNSLEALLQLVAAGLGIALLPRS 154
PRK12684 PRK12684
CysB family HTH-type transcriptional regulator;
16-148 6.86e-05

CysB family HTH-type transcriptional regulator;


Pssm-ID: 237173 [Multi-domain]  Cd Length: 313  Bit Score: 43.81  E-value: 6.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  16 AVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLR-LTPEGEQLQRQAHLLMRQVKAFEAFAREVPHGA 94
Cdd:PRK12684  12 AVRQNFNLTEAAKALYTSQPGVSKAIIELEDELGVEIFTRHGKRLRgLTEPGRIILASVERILQEVENLKRVGKEFAAQD 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 556473977  95 TQDLTLVYDPFTPRAFLHGVIAEMAVR--KIRLSLICASRDESERLLANNDADLAI 148
Cdd:PRK12684  92 QGNLTIATTHTQARYALPAAIKEFKKRypKVRLSILQGSPTQIAEMVLHGQADLAI 147
PRK15243 PRK15243
virulence genes transcriptional activator SpvR;
10-120 9.53e-05

virulence genes transcriptional activator SpvR;


Pssm-ID: 185155 [Multi-domain]  Cd Length: 297  Bit Score: 43.12  E-value: 9.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  10 QLEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQR--QAHLLMrqvkaFEAFA 87
Cdd:PRK15243   8 KLKIFITLMETGSFSIATSVLYITRTPLSRVISDLERELKQRLFIRKNGTLIPTEFAQTIYRkvKSHYIF-----LHALE 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 556473977  88 REV-PHGATQDLTLVYDPFTPRAFLHGVIAEMAV 120
Cdd:PRK15243  83 QEIgPTGKTKQLEIIFDEIYPESLKNLIISALTI 116
ModE COG2005
DNA-binding transcriptional regulator ModE (molybdenum-dependent) [Transcription];
16-83 1.41e-04

DNA-binding transcriptional regulator ModE (molybdenum-dependent) [Transcription];


Pssm-ID: 441608 [Multi-domain]  Cd Length: 118  Bit Score: 40.58  E-value: 1.41e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 556473977  16 AVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIR------DGRTlRLTPEGEQLQRQAHLLMRQVKAF 83
Cdd:COG2005   29 AIDETGSISAAAKAMGMSYKRAWDLIDAMNNLLGEPLVERqtggkgGGGA-RLTPEGRRLLALYRRLEAEAQRA 101
PRK11139 PRK11139
DNA-binding transcriptional activator GcvA; Provisional
 11-69 2.05e-04

DNA-binding transcriptional activator GcvA; Provisional


Pssm-ID: 182990 [Multi-domain]  Cd Length: 297  Bit Score: 42.14  E-value: 2.05e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 556473977  11 LEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQL 69
Cdd:PRK11139  11 LRAFEAAARHLSFTRAAEELFVTQAAVSHQIKALEDFLGLKLFRRRNRSLLLTEEGQRY 69
PRK10837 PRK10837
putative DNA-binding transcriptional regulator; Provisional
 10-89 3.11e-04

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 182768 [Multi-domain]  Cd Length: 290  Bit Score: 41.60  E-value: 3.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  10 QLEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQRQAHLLMRQVKAFEAFARE 89
Cdd:PRK10837   7 QLEVFAEVLKSGSTTQASVMLALSQSAVSAALTDLEGQLGVQLFDRVGKRLVVNEHGRLLYPRALALLEQAVEIEQLFRE 86
PRK10086 PRK10086
DNA-binding transcriptional regulator DsdC;
6-70 3.62e-04

DNA-binding transcriptional regulator DsdC;


Pssm-ID: 182231 [Multi-domain]  Cd Length: 311  Bit Score: 41.53  E-value: 3.62e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556473977   6 YSFAQLEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQ 70
Cdd:PRK10086  14 WQLSKLHTFEVAARHQSFALAADELSLTPSAVSHRINQLEEELGIKLFVRSHRKVELTEEGKRVF 78
PRK11151 PRK11151
DNA-binding transcriptional regulator OxyR; Provisional
 11-87 2.15e-03

DNA-binding transcriptional regulator OxyR; Provisional


Pssm-ID: 182999 [Multi-domain]  Cd Length: 305  Bit Score: 39.24  E-value: 2.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556473977  11 LEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQRQAHLLMRQVKAFEAFA 87
Cdd:PRK11151   6 LEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQAGLLLVDQARTVLREVKVLKEMA 82
PRK12683 PRK12683
transcriptional regulator CysB-like protein; Reviewed
 16-148 2.35e-03

transcriptional regulator CysB-like protein; Reviewed


Pssm-ID: 237172 [Multi-domain]  Cd Length: 309  Bit Score: 38.87  E-value: 2.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  16 AVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDG-RTLRLTPEGEQLQRQAHLLMRQVKAFEAFAREVPHGA 94
Cdd:PRK12683  12 AVRQNFNLTEVANALYTSQSGVSKQIKDLEDELGVEIFIRRGkRLTGLTEPGKELLQIVERMLLDAENLRRLAEQFADRD 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 556473977  95 TQDLTLVYDPFTPRAFLHGVIAEM--AVRKIRLSLICASRDESERLLANNDADLAI 148
Cdd:PRK12683  92 SGHLTVATTHTQARYALPKVVRQFkeVFPKVHLALRQGSPQEIAEMLLNGEADIGI 147
PRK09986 PRK09986
LysR family transcriptional regulator;
11-100 5.27e-03

LysR family transcriptional regulator;


Pssm-ID: 182183 [Multi-domain]  Cd Length: 294  Bit Score: 37.78  E-value: 5.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  11 LEAFTAVAENGSLSKAAVALKKDRTTLRDLVDFLEDGLGYALFIRDGRTLRLTPEGEQLQRQAHLLMRQVKAFEAFAREV 90
Cdd:PRK09986  12 LRYFLAVAEELHFGRAAARLNISQPPLSIHIKELEDQLGTPLFIRHSRSVVLTHAGKILMEESRRLLDNAEQSLARVEQI 91

                         90
                 ....*....|
gi 556473977  91 PHGATQDLTL 100
Cdd:PRK09986  92 GRGEAGRIEI 101
cysB PRK12681
HTH-type transcriptional regulator CysB;
41-89 7.57e-03

HTH-type transcriptional regulator CysB;


Pssm-ID: 183678 [Multi-domain]  Cd Length: 324  Bit Score: 37.57  E-value: 7.57e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 556473977  41 VDFLEDGLGYALFIRDGRTL-RLTPEGEQLQRQAHLLMRQVKAFEAFARE 89
Cdd:PRK12681  37 VRMLEDELGIQIFARSGKHLtQVTPAGEEIIRIAREILSKVESIKSVAGE 86
cbl PRK12679
HTH-type transcriptional regulator Cbl;
44-152 9.08e-03

HTH-type transcriptional regulator Cbl;


Pssm-ID: 183676 [Multi-domain]  Cd Length: 316  Bit Score: 37.10  E-value: 9.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556473977  44 LEDGLGYALFIRDG-RTLRLTPEGEQLQRQAHLLMRQVKAFEAFAREVPHGATQDLTLVYDPFTPRAFLHGVIAEMAVR- 121
Cdd:PRK12679  40 LEDELGIEIFIRRGkRLLGMTEPGKALLVIAERILNEASNVRRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELf 119

                         90       100       110
                 ....*....|....*....|....*....|..
gi 556473977 122 -KIRLSLICASRDESERLLANNDADLAICQAR 152
Cdd:PRK12679 120 pEVRLELIQGTPQEIATLLQNGEADIGIASER 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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