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Conserved domains on  [gi|556474217|ref|WP_023325822|]
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MULTISPECIES: sensor histidine kinase [Enterobacter]

Protein Classification

sensor histidine kinase( domain architecture ID 11461692)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to an external signal

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
297-551 1.48e-72

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


:

Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 235.92  E-value: 1.48e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 297 IHSMLVIPLWEKGVVTGTLKIYYCHAHQITSTLQEMAIGLSQIISTQLEVSRAEQLREMANKAELRALQSKINPHFLFNA 376
Cdd:COG3275   97 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNT 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 377 LNAISSSIRLNPDTARQLIFNLSRYLRYNIELKDDEQIDIKKELYQIKDYIAIEQARFGDKLTVIYDIDEEV-NCVIPSL 455
Cdd:COG3275  177 LNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELlDLLIPPL 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 456 LIQPLVENAIVHGIQPCKGKGVVTISVTESGNRVRIAVRDTGHGIDPKviervesNEMPGNKIGLLNVHHRVKLLYGD-- 533
Cdd:COG3275  257 LLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQPK-------KKKKGSGIGLKNVRERLELLYGDky 329

                        250
                 ....*....|....*....
gi 556474217 534 GLHIQRLEP-GTEIAFYVP 551
Cdd:COG3275  330 SLEIESTDGgGTKVTLKIP 348
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 28-194 1.89e-43

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


:

Pssm-ID: 429599  Cd Length: 170  Bit Score: 152.72  E-value: 1.89e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217   28 IRLFRELLHKSAHSPKELLAVTAIFSLFALFSTWSGVPVE-GSLVNVRIIAVMSGGILFGPWVGVITGVIAGTHRYLidI 106
Cdd:pfam07694   1 IPLFRRLLSKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYF--L 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217  107 GGVTAVPCFITSIIAGVLSGWISRKIPKKQR---WRAGIVAGMVCETLTMILVVVWAPTTELGLDIVSKIGIPMIL-GSV 182
Cdd:pfam07694  79 GGFTALACGISTILAGLIAGLLHRRLKRRRRlisPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILvNSL 158

                         170
                  ....*....|..
gi 556474217  183 CIGFIVLLVQSV 194
Cdd:pfam07694 159 GTAIFLSILRDR 170
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
297-551 1.48e-72

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 235.92  E-value: 1.48e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 297 IHSMLVIPLWEKGVVTGTLKIYYCHAHQITSTLQEMAIGLSQIISTQLEVSRAEQLREMANKAELRALQSKINPHFLFNA 376
Cdd:COG3275   97 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNT 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 377 LNAISSSIRLNPDTARQLIFNLSRYLRYNIELKDDEQIDIKKELYQIKDYIAIEQARFGDKLTVIYDIDEEV-NCVIPSL 455
Cdd:COG3275  177 LNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELlDLLIPPL 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 456 LIQPLVENAIVHGIQPCKGKGVVTISVTESGNRVRIAVRDTGHGIDPKviervesNEMPGNKIGLLNVHHRVKLLYGD-- 533
Cdd:COG3275  257 LLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQPK-------KKKKGSGIGLKNVRERLELLYGDky 329

                        250
                 ....*....|....*....
gi 556474217 534 GLHIQRLEP-GTEIAFYVP 551
Cdd:COG3275  330 SLEIESTDGgGTKVTLKIP 348
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 452-551 3.79e-45

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 154.54  E-value: 3.79e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 452 IPSLLIQPLVENAIVHGIQPCKGKGVVTISVTE-SGNRVRIAVRDTGHGIDPKVIERVESNEMPGNKIGLLNVHHRVKLL 530
Cdd:cd16955    1 IPKLMIQPLVENAIVHGIQEKKGKGVVKISVKKqLKNRLHIAVEDNGIGISPKVIERVEQDEMPGNKIGLLNVHQRLKLG 80

                         90       100
                 ....*....|....*....|..
gi 556474217 531 YGDGLHIQRL-EPGTEIAFYVP 551
Cdd:cd16955   81 YGEGLHIRSRpDPGTLIAFYIP 102
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 28-194 1.89e-43

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


Pssm-ID: 429599  Cd Length: 170  Bit Score: 152.72  E-value: 1.89e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217   28 IRLFRELLHKSAHSPKELLAVTAIFSLFALFSTWSGVPVE-GSLVNVRIIAVMSGGILFGPWVGVITGVIAGTHRYLidI 106
Cdd:pfam07694   1 IPLFRRLLSKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYF--L 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217  107 GGVTAVPCFITSIIAGVLSGWISRKIPKKQR---WRAGIVAGMVCETLTMILVVVWAPTTELGLDIVSKIGIPMIL-GSV 182
Cdd:pfam07694  79 GGFTALACGISTILAGLIAGLLHRRLKRRRRlisPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILvNSL 158

                         170
                  ....*....|..
gi 556474217  183 CIGFIVLLVQSV 194
Cdd:pfam07694 159 GTAIFLSILRDR 170
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 359-438 2.86e-31

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 116.00  E-value: 2.86e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217  359 AELRALQSKINPHFLFNALNAISSSIRLNPDTARQLIFNLSRYLRYNIElKDDEQIDIKKELYQIKDYIAIEQARFGDKL 438
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLY-EGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 453-551 1.98e-12

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 63.82  E-value: 1.98e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217   453 PSLLIQpLVENAIVHGIQPCKGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERV---------ESNEMPGNKIGLLNV 523
Cdd:smart00387   3 PDRLRQ-VLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIfepffrtdkRSRKIGGTGLGLSIV 81

                           90       100
                   ....*....|....*....|....*...
gi 556474217   524 HHRVKLLYGDGLHIQRLEPGTEIAFYVP 551
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITLP 109
ECF-S COG4720
ECF-type riboflavin transporter, membrane (S) component [Coenzyme transport and metabolism];
46-160 2.04e-06

ECF-type riboflavin transporter, membrane (S) component [Coenzyme transport and metabolism];


Pssm-ID: 443755 [Multi-domain]  Cd Length: 170  Bit Score: 47.92  E-value: 2.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217  46 LAVTAIFS-LFALFSTWSGVPV--EGSLVNVRIIAVMSGGILFGPWVGVITGVIAGThryLIDI---GGVTAVPCFITSI 119
Cdd:COG4720    8 LVLIALFAaLVFVLTMFIKIPIpiTNGYIHLGDAFIYLAALLFGPKAGALAGGIGSA---LADLlsgYPIWAPWTFIIKG 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 556474217 120 IAGVLSGWISRKIPKKQRWRagIVAGMVCETLTMILVVVWA 160
Cdd:COG4720   85 LEGLIVGLIAKKLKKKSFKK--IILANILGGLVMVIGYYLA 123
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
453-508 4.07e-05

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 46.32  E-value: 4.07e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 556474217 453 PSLLIQPLVeNAIVHGIQPCKGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERV 508
Cdd:PRK10364 346 PDRLTQVLL-NLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAI 400
spIIAB TIGR01925
anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates ...
 461-501 4.92e-03

anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates spore development in B subtilis. SpoIIAB binds to sigma F, preventing formation of the transcription complex at the promoter. SpoIIAA (anti-anti-sigma F factor) binds to SpoIIAB to inhibit association with sigma F, however SpoIIAB can phosphorylate SpoIIAA, causing disassociation of the SpoIIAA/B complex. The SpoIIE phosphatase dephosphorylates SpoIIAA. [Regulatory functions, Protein interactions, Cellular processes, Sporulation and germination]


Pssm-ID: 130980 [Multi-domain]  Cd Length: 137  Bit Score: 37.59  E-value: 4.92e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 556474217  461 VENAIVHGIQpCKGKGVVTISVTESGNRVRIAVRDTGHGID 501
Cdd:TIGR01925  48 VTNAIIHGYE-ENCEGVVYISATIEDHEVYITVRDEGIGIE 87
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
297-551 1.48e-72

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 235.92  E-value: 1.48e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 297 IHSMLVIPLWEKGVVTGTLKIYYCHAHQITSTLQEMAIGLSQIISTQLEVSRAEQLREMANKAELRALQSKINPHFLFNA 376
Cdd:COG3275   97 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNT 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 377 LNAISSSIRLNPDTARQLIFNLSRYLRYNIELKDDEQIDIKKELYQIKDYIAIEQARFGDKLTVIYDIDEEV-NCVIPSL 455
Cdd:COG3275  177 LNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELlDLLIPPL 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 456 LIQPLVENAIVHGIQPCKGKGVVTISVTESGNRVRIAVRDTGHGIDPKviervesNEMPGNKIGLLNVHHRVKLLYGD-- 533
Cdd:COG3275  257 LLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQPK-------KKKKGSGIGLKNVRERLELLYGDky 329

                        250
                 ....*....|....*....
gi 556474217 534 GLHIQRLEP-GTEIAFYVP 551
Cdd:COG3275  330 SLEIESTDGgGTKVTLKIP 348
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
324-554 7.36e-61

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 207.95  E-value: 7.36e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 324 QITSTLQEMaigLSQIISTQLEVSRAEQLRemaNKAELRALQSKINPHFLFNALNAISSSIRLN-PDTARQLIFNLSRYL 402
Cdd:COG2972  213 ILARSFNEM---VERIKELIEEVYELELEK---KEAELKALQAQINPHFLFNTLNSIRWLAELEdPEEAEEMLEALSKLL 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 403 RYNIElKDDEQIDIKKELYQIKDYIAIEQARFGDKLTVIYDIDEEV-NCVIPSLLIQPLVENAIVHGIQPCKGKGVVTIS 481
Cdd:COG2972  287 RYSLS-KGDELVTLEEELELIKSYLEIQKLRFGDRLEVEIEIDEELlDLLIPKLILQPLVENAIEHGIEPKEGGGTIRIS 365

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 556474217 482 VTESGNRVRIAVRDTGHGIDPKVIERV---ESNEMPGNKIGLLNVHHRVKLLYGD--GLHIQ-RLEPGTEIAFYVPNER 554
Cdd:COG2972  366 IRKEGDRLVITVEDNGVGMPEEKLEKLleeLSSKGEGRGIGLRNVRERLKLYYGEeyGLEIEsEPGEGTTVTIRIPLEE 444
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 452-551 3.79e-45

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 154.54  E-value: 3.79e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 452 IPSLLIQPLVENAIVHGIQPCKGKGVVTISVTE-SGNRVRIAVRDTGHGIDPKVIERVESNEMPGNKIGLLNVHHRVKLL 530
Cdd:cd16955    1 IPKLMIQPLVENAIVHGIQEKKGKGVVKISVKKqLKNRLHIAVEDNGIGISPKVIERVEQDEMPGNKIGLLNVHQRLKLG 80

                         90       100
                 ....*....|....*....|..
gi 556474217 531 YGDGLHIQRL-EPGTEIAFYVP 551
Cdd:cd16955   81 YGEGLHIRSRpDPGTLIAFYIP 102
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 452-551 1.94e-44

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 152.99  E-value: 1.94e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 452 IPSLLIQPLVENAIVHGIQPCKGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERVESNEMPGNKIGLLNVHHRVKLLY 531
Cdd:cd16924    1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPKVLNILGKKPKEGNGIGLYNVHQRLILLF 80

                         90       100
                 ....*....|....*....|...
gi 556474217 532 GDGLHIQRL---EPGTEIAFYVP 551
Cdd:cd16924   81 GEDYGIHIAsepDKGTRITFTIP 103
5TM-5TMR_LYT pfam07694
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ...
 28-194 1.89e-43

5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).


Pssm-ID: 429599  Cd Length: 170  Bit Score: 152.72  E-value: 1.89e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217   28 IRLFRELLHKSAHSPKELLAVTAIFSLFALFSTWSGVPVE-GSLVNVRIIAVMSGGILFGPWVGVITGVIAGTHRYLidI 106
Cdd:pfam07694   1 IPLFRRLLSKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYF--L 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217  107 GGVTAVPCFITSIIAGVLSGWISRKIPKKQR---WRAGIVAGMVCETLTMILVVVWAPTTELGLDIVSKIGIPMIL-GSV 182
Cdd:pfam07694  79 GGFTALACGISTILAGLIAGLLHRRLKRRRRlisPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILvNSL 158

                         170
                  ....*....|..
gi 556474217  183 CIGFIVLLVQSV 194
Cdd:pfam07694 159 GTAIFLSILRDR 170
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 359-438 2.86e-31

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 116.00  E-value: 2.86e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217  359 AELRALQSKINPHFLFNALNAISSSIRLNPDTARQLIFNLSRYLRYNIElKDDEQIDIKKELYQIKDYIAIEQARFGDKL 438
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLY-EGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 452-551 5.78e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 67.85  E-value: 5.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 452 IPSLLIQPLVENAIVHGIQPCKGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERVESNEMPGnkIGLLNVHHRVKLLY 531
Cdd:cd16956    1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTLARILIRSSNG--LGLNLVDKRLRQAF 78

                         90       100
                 ....*....|....*....|...
gi 556474217 532 GD--GLHIQ-RLEPGTEIAFYVP 551
Cdd:cd16956   79 GNdyGLDIEcAPGEGTRITIRLP 101
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 452-551 1.09e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 64.37  E-value: 1.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 452 IPSLLIQPLVENAIVHGIQPCKGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIER-----VESNEmpGNKIGLLNVHHR 526
Cdd:cd16957    1 VPPFALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLlgkttVTSEK--GTGTALENLNRR 78

                         90       100
                 ....*....|....*....|....*...
gi 556474217 527 VKLLYGD--GLHIQRLE-PGTEIAFYVP 551
Cdd:cd16957   79 LIGLFGSeaCLHIESEVhGGTEVWFVIP 106
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 453-551 1.98e-12

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 63.82  E-value: 1.98e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217   453 PSLLIQpLVENAIVHGIQPCKGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERV---------ESNEMPGNKIGLLNV 523
Cdd:smart00387   3 PDRLRQ-VLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIfepffrtdkRSRKIGGTGLGLSIV 81

                           90       100
                   ....*....|....*....|....*...
gi 556474217   524 HHRVKLLYGDGLHIQRLEPGTEIAFYVP 551
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITLP 109
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 361-508 1.08e-08

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 57.12  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 361 LRALQSKINPHFLFNALNAISSSIRlnpdTARQLIFNLSRYLRynielKDDEQ---IDIKKelyQIKDYIAIEQARFGDK 437
Cdd:COG4191  168 RRRLEDEPDPEELREALERILEGAE----RAAEIVRSLRAFSR-----RDEEErepVDLNE---LIDEALELLRPRLKAR 235

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556474217 438 -LTVIYDIDEEVNCVI--PSLLIQ---PLVENAIvHGIQPcKGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERV 508
Cdd:COG4191  236 gIEVELDLPPDLPPVLgdPGQLEQvllNLLINAI-DAMEE-GEGGRITISTRREGDYVVISVRDNGPGIPPEVLERI 310
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
376-508 1.92e-08

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 56.07  E-value: 1.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 376 ALNAISSSIrlnpDTARQLI---FNLSRYLRYNIELkDDEQIDIKKELYQIKDYIaieQARFGDK-LTVIYDIDEEVNCV 451
Cdd:COG0642  146 YLETILRSA----DRLLRLIndlLDLSRLEAGKLEL-EPEPVDLAELLEEVVELF---RPLAEEKgIELELDLPDDLPTV 217

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 556474217 452 I--PSLLIQ---PLVENAIVHGiqpcKGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERV 508
Cdd:COG0642  218 RgdPDRLRQvllNLLSNAIKYT----PEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERI 275
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 456-551 2.52e-08

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 51.99  E-value: 2.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217  456 LIQPLVENAIVHgiQPCKGKGVVTIsvtESGNRVRIAVRDTGHGIDPKVIERV-------ESNEMPGNKIGLLNVHHRVK 528
Cdd:pfam02518   9 VLSNLLDNALKH--AAKAGEITVTL---SEGGELTLTVEDNGIGIPPEDLPRIfepfstaDKRGGGGTGLGLSIVRKLVE 83

                          90       100
                  ....*....|....*....|...
gi 556474217  529 LLYGDGLHIQRLEPGTEIAFYVP 551
Cdd:pfam02518  84 LLGGTITVESEPGGGTTVTLTLP 106
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
460-546 5.08e-08

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 51.84  E-value: 5.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 460 LVENAIVHGiQPCKGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERVESNEMPGNkIGLLNVHHRVkllygDGLHIQR 539
Cdd:COG2172   42 AVTNAVRHA-YGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYSTLAEGG-RGLFLIRRLM-----DEVEYES 114


                 ....*..
gi 556474217 540 LEPGTEI 546
Cdd:COG2172  115 DPGGTTV 121
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 342-555 7.35e-08

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 54.85  E-value: 7.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 342 TQLEvSRAEQLREMANKAE-LRALQskinpHFLFNALNAISSSIRLN-PDTARQLIFNLSrylrynielkDDEQIDIKKE 419
Cdd:COG3290  174 TELE-RLEEELEGVKELAEaLRAQR-----HDFRNHLHTISGLLQLGeYDEALEYIDEIS----------EELQELIDSL 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 420 LYQIKDYI-------AIEQARfGDKLTVIYDIDeevnCVIPSLLIQP---------LVENAIVHGIQPCKGKGVVTISVT 483
Cdd:COG3290  238 LSRIGNPVlaalllgKAARAR-ERGIDLTIDID----SDLPDLPLSDtdlvtilgnLLDNAIEAVEKLPEEERRVELSIR 312

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556474217 484 ESGNRVRIAVRDTGHGIDPKVIERVESNEMPGNK-----IGLLNVHHRVKLLYGDgLHIQRLEP-GTEIAFYVPNERS 555
Cdd:COG3290  313 DDGDELVIEVEDSGPGIPEELLEKIFERGFSTKLgegrgLGLALVKQIVEKYGGT-IEVESEEGeGTVFTVRLPKEGE 389
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
395-508 1.66e-07

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 53.79  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 395 IFNLSRYLRYNIELkDDEQIDIKKELYQIKDYIaieQARFGDK-LTVIYDIDEEVNCVI--PSLLIQP---LVENAIVHG 468
Cdd:COG5002  222 LLDLSRLESGELKL-EKEPVDLAELLEEVVEEL---RPLAEEKgIELELDLPEDPLLVLgdPDRLEQVltnLLDNAIKYT 297

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 556474217 469 iqpcKGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERV 508
Cdd:COG5002  298 ----PEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRI 333
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
376-555 2.93e-07

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 51.83  E-value: 2.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 376 ALNAISSSIRLNPDTARQLIFNL---SRYLRYNIE--LK----DDEQIDIKKELYQIKDYI--AIEQARF---GDKLTVI 441
Cdd:COG2205   37 AAELLLDEEDLSPEERRELLEIIresAERLLRLIEdlLDlsrlESGKLSLELEPVDLAELLeeAVEELRPlaeEKGIRLE 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 442 YDIDEEVNCVI--PSLLIQ---PLVENAIVHGiqpcKGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERV-------- 508
Cdd:COG2205  117 LDLPPELPLVYadPELLEQvlaNLLDNAIKYS----PPGGTITISARREGDGVRISVSDNGPGIPEEELERIferfyrgd 192

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 556474217 509 ESNEMPGNKIGLLNVHHRVKLLYGDgLHIQ-RLEPGTEIAFYVPNERS 555
Cdd:COG2205  193 NSRGEGGTGLGLAIVKRIVEAHGGT-IWVEsEPGGGTTFTVTLPLAES 239
ECF-ribofla_trS pfam07155
ECF-type riboflavin transporter, S component; This family is the substrate-binding component ...
 46-191 4.70e-07

ECF-type riboflavin transporter, S component; This family is the substrate-binding component (S component) of the energy coupling-factor (ECF)-type riboflavin transporter. It is a transmembrane protein which binds riboflavin, and is responsible for riboflavin-uptake by cells.


Pssm-ID: 429320  Cd Length: 167  Bit Score: 49.94  E-value: 4.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217   46 LAVTAIFS-LFALFSTWSGVPVEGSLVNVRI--IAVMSGGILFGPWVGVITGVIAGTHRYLIDIGGVTAVPCFITSIIAG 122
Cdd:pfam07155   4 VVAIAIGAaLFVVLTRFISIPTPNTKGYINLgdAFLALAAVLFGPVAGFLVGFIGHALKDLLSGYGIWWPWTLIISGLEG 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556474217  123 VLSGWISRKIPKKQRWRAGIVAGMVCETLTMIL--VVVWAPTTELGLDIVS----KIGIPMILGSVCIGFIVLLV 191
Cdd:pfam07155  84 LIVGLIAKRLGKNLKNGVFNIKGLLLFNLVMVIgyVIAWGLLAPFGDLIYSepanKVFLQSIPANIIQAVVGAII 158
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 416-551 8.19e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 48.18  E-value: 8.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 416 IKKELYQIKDYIAIEQARFGDKLTVI---YDIDEEVNCVIpSLLIQPLVENAIVHGIQPcKGKGVVTISVTESGNRVRIA 492
Cdd:cd16951    1 LGEYINRIASAINAIHAVGDIRINITgdtGPVSSEVATAI-GLVVNELLQNALKHAFSD-REGGTITIRSVVDGDYLRIT 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 556474217 493 VRDTGHGIDpkvierVESNEMPGNKIGLLNVHHRVKLLYGDGLHIQRLEPGTEIAFYVP 551
Cdd:cd16951   79 VIDDGVGLP------QDEDWPNKGSLGLQIVRSLVEGELKAFLEVQSAENGTRVNIDIP 131
ECF_trnsprt pfam12822
ECF transporter, substrate-specific component; Energy-coupling factor (ECF) transporters ...
 46-159 1.35e-06

ECF transporter, substrate-specific component; Energy-coupling factor (ECF) transporters consist of a substrate-specific component (known as the S component), and an energy-coupling module. The substrate-binding component is a small integral membrane protein which captures specific substrates and forms an active transporter in the presence of the energy-coupling AT module.


Pssm-ID: 432808  Cd Length: 157  Bit Score: 48.45  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217   46 LAVTAIFS----LFALFSTWSGVPVEGSLVNvriIAVMSGGILFGPWVGVITGVIAGTHRYLIDIG-GVTAVPCFI-TSI 119
Cdd:pfam12822   3 LVIIALLSalsiVLMFTPPFPPIPLKIDLSH---IPALLGALLLGPLAGILIGLLTSLLSALTTGGgGPTGEPANFlPGI 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 556474217  120 IAGVLSGWISRKIPKKQRWRA--GIVAGMVCETLTMILVVVW 159
Cdd:pfam12822  80 LIGLVAGYLYKYGRNKKKKRIllALILGTILGTLVATLLNLL 121
ECF-S COG4720
ECF-type riboflavin transporter, membrane (S) component [Coenzyme transport and metabolism];
46-160 2.04e-06

ECF-type riboflavin transporter, membrane (S) component [Coenzyme transport and metabolism];


Pssm-ID: 443755 [Multi-domain]  Cd Length: 170  Bit Score: 47.92  E-value: 2.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217  46 LAVTAIFS-LFALFSTWSGVPV--EGSLVNVRIIAVMSGGILFGPWVGVITGVIAGThryLIDI---GGVTAVPCFITSI 119
Cdd:COG4720    8 LVLIALFAaLVFVLTMFIKIPIpiTNGYIHLGDAFIYLAALLFGPKAGALAGGIGSA---LADLlsgYPIWAPWTFIIKG 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 556474217 120 IAGVLSGWISRKIPKKQRWRagIVAGMVCETLTMILVVVWA 160
Cdd:COG4720   85 LEGLIVGLIAKKLKKKSFKK--IILANILGGLVMVIGYYLA 123
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 455-550 2.91e-06

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 45.72  E-value: 2.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 455 LLIQPLVENAIVHGiQPCKGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERVESNEMPGNkIGLLNVHHRVkllygDG 534
Cdd:cd16936    3 LAVSEAVTNAVRHA-YRHDGPGPVRLELDLDPDRLRVEVTDSGPGFDPLRPADPDAGLREGG-RGLALIRALM-----DE 75

                         90
                 ....*....|....*.
gi 556474217 535 LHIQRLEPGTEIAFYV 550
Cdd:cd16936   76 VGYRRTPGGKTVWLEL 91
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 430-508 3.92e-06

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 49.58  E-value: 3.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 430 EQARFGDKLTVIYDIDEEVNCVI--PSLLIQP---LVENAIvhgiQPCKGKGVVTISVTESGNRVRIAVRDTGHGIDPKV 504
Cdd:COG5000  290 EPALKEKDIRLELDLDPDLPEVLadRDQLEQVlinLLKNAI----EAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEV 365


                 ....
gi 556474217 505 IERV 508
Cdd:COG5000  366 LERI 369
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 453-508 1.55e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 43.95  E-value: 1.55e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 556474217 453 PSLLIQPLVeNAIVHGIQPCKGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERV 508
Cdd:cd16943    1 PSQLNQVLL-NLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRI 55
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
423-508 1.70e-05

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 47.15  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 423 IKDYIAIEQARFGDKLTVIYDIDEEVNCVI--PSLLIQpLVENAIVHGIQPCKGKGVVTISV----------TESGNRVR 490
Cdd:COG3852  210 LERVLELLRAEAPKNIRIVRDYDPSLPEVLgdPDQLIQ-VLLNLVRNAAEAMPEGGTITIRTrverqvtlggLRPRLYVR 288

                         90
                 ....*....|....*...
gi 556474217 491 IAVRDTGHGIDPKVIERV 508
Cdd:COG3852  289 IEVIDNGPGIPEEILDRI 306
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 460-507 2.76e-05

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 44.88  E-value: 2.76e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 556474217 460 LVENAIVHGIQP-----CKGK---GVVTISVTESGNRVRIAVRDTGHGIDPKVIER 507
Cdd:cd16916   46 LLRNAVDHGIEApeerlAAGKppeGTITLRAEHQGNQVVIEVSDDGRGIDREKIRE 101
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
460-507 2.84e-05

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 46.71  E-value: 2.84e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556474217 460 LVENAIVHGIQP-----CKGK---GVVTISVTESGNRVRIAVRDTGHGIDP-----KVIER 507
Cdd:COG0643  285 LVRNAVDHGIETpeerlAAGKpetGTITLSAYHEGGRVVIEVSDDGRGLDLekiraKAIEK 345
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 379-520 3.84e-05

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 46.32  E-value: 3.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 379 AISSSIRLnpdtaRQLIFNLSRYLRYNIELKDDEQIDIKKELYQIKD--YIAIEQARFgdklTVIYDIDEEVNCvIPSLL 456
Cdd:COG4251  326 IRDAAERM-----QALIDDLLAYSRVGRQELEFEPVDLNELLEEVLEdlEPRIEERGA----EIEVGPLPTVRG-DPTLL 395

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556474217 457 ---IQPLVENAIVHGIQpcKGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERV--------ESNEMPGNKIGL 520
Cdd:COG4251  396 rqvFQNLISNAIKYSRP--GEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIfeifqrlhSRDEYEGTGIGL 468
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
453-508 4.07e-05

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 46.32  E-value: 4.07e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 556474217 453 PSLLIQPLVeNAIVHGIQPCKGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERV 508
Cdd:PRK10364 346 PDRLTQVLL-NLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAI 400
GAF COG2203
GAF domain [Signal transduction mechanisms];
130-462 4.66e-05

GAF domain [Signal transduction mechanisms];


Pssm-ID: 441805 [Multi-domain]  Cd Length: 712  Bit Score: 46.34  E-value: 4.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 130 RKIPKKQRWRAGIVAGMVCETLTMILVVVWAPTTELGLDIVSKIGIPMILGSVCIGFIVLLVQSVEGEKEASAARQAKLA 209
Cdd:COG2203  117 VALALAEALAARLLDLLLLGLGGRLRGVVLRGLRSAALLLSRVDTDLVGQLAALAGLILDIARLLTQRARLELERLALLN 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 210 --LDIANKTLPLfrhvnAESLRQVCEIIRHDIHADAVAITNIDH------VLAYVGVGEHNYRDNDDTISPTtRQAINYG 281
Cdd:COG2203  197 eiSQALRSALDL-----EELLQRILELAGELLGADRGAILLVDEdggeleLVAAPGLPEEELGRLPLGEGLA-GRALRTG 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 282 KIII-----------KNNDEAHRTPEIHSMLVIPLWEKGVVTGTLKIYYCHAHQITSTLQEMAIGLSQIISTQLEVSRAE 350
Cdd:COG2203  271 EPVVvndastdprfaPSLRELLLALGIRSLLCVPLLVDGRLIGVLALYSKEPRAFTEEDLELLEALADQAAIAIERARLY 350

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 351 QLREMANKAELRALQSKINPHFLFNALNAISSSIRLNPDTARQLIFNLSRYLRYNIELKDDEQIDIKKELYQIKDYIAIE 430
Cdd:COG2203  351 EALEAALAALLQELALLRLLLDLELTLLRLRQLLLELLLALLLLLSLLGAELLLLLLDAADLSGLLALEGLLLLDLLLLL 430

                        330       340       350
                 ....*....|....*....|....*....|..
gi 556474217 431 QARFGDKLTVIYDIDEEVNCVIPSLLIQPLVE 462
Cdd:COG2203  431 LLLRRILLLRVLRRLLLGDEEGLVLLLALAEL 462
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
478-551 6.11e-05

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 44.99  E-value: 6.11e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556474217 478 VTISVTESGNRVRIAVRDTGHGIDPkviervesNEMPGNKIGLLNVHHRVKLLYGDgLHIQRLEP-GTEIAFYVP 551
Cdd:COG4585  183 VTVTLEVDDGELTLTVRDDGVGFDP--------EAAPGGGLGLRGMRERAEALGGT-LTIGSAPGgGTRVRATLP 248
CbiM COG0310
ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism];
81-159 2.98e-04

ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440079  Cd Length: 198  Bit Score: 42.03  E-value: 2.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217  81 GGILFGPWVGVITGVIAgthryLI-------DiGGVTAVPCFITSI-IAGVLSGWISRKIPKKQRWR---AGIVAGMVCE 149
Cdd:COG0310   74 AAILLGPWAAFLAITIV-----LLlqallfgD-GGLTTLGANIFNMaIPGPFVGYLVYRLLRKLGPRlalAAFLAGALGV 147

                         90
                 ....*....|
gi 556474217 150 TLTMILVVVW 159
Cdd:COG0310  148 LLAALLTALE 157
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 457-551 6.96e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 38.69  E-value: 6.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 457 IQPLVENAIVHGiqpckGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERVESNempgnkiGLLNVHHRVKLLYGDgLH 536
Cdd:cd16917    5 VQEALTNALKHA-----GASRVRVTLSYTADELTLTVVDDGVGFDGPAPPGGGGF-------GLLGMRERAELLGGT-LT 71

                         90
                 ....*....|....*.
gi 556474217 537 IQRLEP-GTEIAFYVP 551
Cdd:cd16917   72 IGSRPGgGTRVTARLP 87
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 476-507 1.13e-03

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 41.64  E-value: 1.13e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 556474217 476 GVVTISVTESGNRVRIAVRDTGHGIDPKVIER 507
Cdd:COG5805  415 GTITIHTEEEDNSVIIRVIDEGIGIPEERLKK 446
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
454-566 2.19e-03

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 40.82  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 454 SLLIQPLVENAIVHGIQPCKGKGVVTISVTES---------------GNRVRIAVRDTGHGIDPKVIERV-E---SNEMP 514
Cdd:PRK13837 558 PAELQQVLMNLCSNAAQAMDGAGRVDISLSRAklrapkvlshgvlppGRYVLLRVSDTGAGIDEAVLPHIfEpffTTRAG 637

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 556474217 515 GNKIGLLNVHHRVKLLYGDGLHIQRLEPGTEIAFYVP-NERSPVHSATSLLPQ 566
Cdd:PRK13837 638 GTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPpSSKVPVAPQAFFGPG 690
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 423-504 3.10e-03

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 40.27  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 423 IKDYI-----AIEQARFGDKLTVIYDIDE---EVNCVIP-SLLIQPLVENAIVHGiQPCKGKGVVTISVTESGNRVRIAV 493
Cdd:COG3920  361 LRDYLrellePLRDSYGGRGIRIELDGPDvelPADAAVPlGLILNELVTNALKHA-FLSGEGGRIRVSWRREDGRLRLTV 439

                         90
                 ....*....|.
gi 556474217 494 RDTGHGIDPKV 504
Cdd:COG3920  440 SDNGVGLPEDV 450
HATPase_SpoIIAB-like cd16942
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ...
 461-500 3.12e-03

Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.


Pssm-ID: 340418 [Multi-domain]  Cd Length: 135  Bit Score: 38.29  E-value: 3.12e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 556474217 461 VENAIVHGIQpCKGKGVVTISVTESGNRVRIAVRDTGHGI 500
Cdd:cd16942   47 VTNAIIHGYN-NDPNGIVSISVIIEDGVVHLTVRDEGVGI 85
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
47-194 3.94e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.89  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217  47 AVTAIFSLFALFSTWSGVPVEGSLVNV-------------RIIAVMSGGILFGpwVGVITGVIAGTHRYLIDIG----GV 109
Cdd:COG2211  191 VLGLLAFLLTFFGTKERPVPEEEKVSLkeslkallknrpfLLLLLAYLLFFLA--LALVAALLLYYFKYVLGLSaalvGL 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 110 TAVPCFITSIIAGVLSGWISRKIPKKQRWRAGIVAGMVCetltmILVVVWAPTTELGLdivskIGIPMILGSVCIGFIVL 189
Cdd:COG2211  269 LLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG-----LLLLFFLGPGNLWL-----LLVLAALAGIGLGAILV 338


                 ....*
gi 556474217 190 LVQSV 194
Cdd:COG2211  339 LPWAM 343
CbiM pfam01891
Cobalt uptake substrate-specific transmembrane region; This family of proteins forms part of ...
 31-158 4.78e-03

Cobalt uptake substrate-specific transmembrane region; This family of proteins forms part of the cobalt-transport complex in prokaryotes, CbiMNQO. CbiMNQO and NikMNQO are the most widespread groups of microbial transporters for cobalt and nickel ions and are unusual uptake systems as they consist of eg two transmembrane components (CbiM and CbiQ), a small membrane-bound component (CbiN) and an ATP-binding protein (CbiO) but no extracytoplasmic solute-binding protein. Similar components constitute the nickel transporters with some variability in the small membrane-bound component, either NikN or NikL, which are not similar to CbiN at the sequence level. CbiM is the substrate-specific component of the complex and is a seven-transmembrane protein. The CbiMNQO and NikMNQO systems form part of the coenzyme B12 biosynthesis pathway. The NikM protein is pfam10670.


Pssm-ID: 460375 [Multi-domain]  Cd Length: 202  Bit Score: 38.71  E-value: 4.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217   31 FRELLHKSAHSPKELLAV-TAIFSLFALFSTWSGVPVEGSLVNVRIIavmsgGILFGPWVGVITGVIAgthrYLIDI--- 106
Cdd:pfam01891  27 LRRLRKELKERRIPLLALlAAFFFAASMINIPIPGGSSGHLLGAGLL-----AILLGPWAAFLAIAVV----LLLQAllf 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 556474217  107 --GGVTAVP--CFITSIIAGVLSGWISRKIPKKQRWRAGIVAGMVCETLTMILVVV 158
Cdd:pfam01891  98 gdGGITTLGanTLNMAVPGVLVGYLVYRLLSKLRVLLAAFLAGFLAVLLAALLVAL 153
spIIAB TIGR01925
anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates ...
 461-501 4.92e-03

anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates spore development in B subtilis. SpoIIAB binds to sigma F, preventing formation of the transcription complex at the promoter. SpoIIAA (anti-anti-sigma F factor) binds to SpoIIAB to inhibit association with sigma F, however SpoIIAB can phosphorylate SpoIIAA, causing disassociation of the SpoIIAA/B complex. The SpoIIE phosphatase dephosphorylates SpoIIAA. [Regulatory functions, Protein interactions, Cellular processes, Sporulation and germination]


Pssm-ID: 130980 [Multi-domain]  Cd Length: 137  Bit Score: 37.59  E-value: 4.92e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 556474217  461 VENAIVHGIQpCKGKGVVTISVTESGNRVRIAVRDTGHGID 501
Cdd:TIGR01925  48 VTNAIIHGYE-ENCEGVVYISATIEDHEVYITVRDEGIGIE 87
envZ PRK09467
osmolarity sensor protein; Provisional
 401-508 5.38e-03

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 39.51  E-value: 5.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217 401 YLRYNIELkDDEQIDIKKelyQIKDYIAIEQARFGDkltviydIDEEVNCVIPSLLIQP---------LVENAIVHGiqp 471
Cdd:PRK09467 282 YLRTGQEM-PMEMADLNA---LLGEVIAAESGYERE-------IETALQPGPIEVPMNPiaikralanLVVNAARYG--- 347

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 556474217 472 ckgKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERV 508
Cdd:PRK09467 348 ---NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHL 381
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 460-508 6.40e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 36.50  E-value: 6.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 556474217 460 LVENAIVHGIQPCKGKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERV 508
Cdd:cd16915    8 LIDNALDALAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKV 56
MFS_1 pfam07690
Major Facilitator Superfamily;
15-202 7.28e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.94  E-value: 7.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217   15 AALMLICLFFLIRIRLFRELLHKSAHSPKELLAVTAIFSLFALFSTWsgvpvegslvnVRIIAVMSGGILFGpwVGVITG 94
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLW-----------LLLALLLFGFAFFG--LLTYLP 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556474217   95 VIAGTHRYLIDIGGVTAVPCFITSIIAGVLSGWISRKIPKKQRWRAGIVAGMVCetltMILVVVWAPTTELGLDIVSKIG 174
Cdd:pfam07690 225 LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA----ALGLLLLSLTLSSLWLLLALLL 300

                         170       180
                  ....*....|....*....|....*...
gi 556474217  175 IPMILGSVCIGFIVLLVQSVEGEKEASA 202
Cdd:pfam07690 301 LGFGFGLVFPALNALVSDLAPKEERGTA 328
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 460-508 8.59e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 36.27  E-value: 8.59e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 556474217 460 LVENAIVHGiqpckgKGVVTISVTESGNRVRIAVRDTGHGIDPKVIERV 508
Cdd:cd16950    8 LVDNALRYG------GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDEL 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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