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Conserved domains on  [gi|556475800|ref|WP_023327405|]
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MULTISPECIES: cyclopropane-fatty-acyl-phospholipid synthase family protein [Enterobacter]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 11454891)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.-.-
Gene Ontology:  GO:0032259|GO:0008757|GO:1904047|GO:0008168
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CMAS super family cl47167
Mycolic acid cyclopropane synthetase; This family consist of ...
 129-401 2.08e-93

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


The actual alignment was detected with superfamily member pfam02353:

Pssm-ID: 481507 [Multi-domain]  Cd Length: 272  Bit Score: 281.52  E-value: 2.08e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800  129 SRAQARENIAAHYDLGNTFYAHFLDRELLYSSALFTADEQDLTTAQQAKMARLCDQLALSEADHLLEIGTGWGAMAEYAA 208
Cdd:pfam02353   1 SKTRDAENIQAHYDLSNDFFALFLDPTMTYSCAYFERPDMTLEEAQQAKLDLILDKLGLKPGMTLLDIGCGWGGLMRRAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800  209 RHYGCRVTTTTLSQEQYVWATERIARAGLQDRVEVLLCDYRDLTGQYDKLVSIEMIEAVGQRYLPTFFRTCQARLRPGGR 288
Cdd:pfam02353  81 ERYDVNVVGLTLSKNQYKLARKRVAAEGLARKVEVLLQDYRDFDEPFDRIVSVGMFEHVGHENYDTFFKKLYNLLPPGGL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800  289 MAIQAITIQDQRYR-DYSKSVDFIQRYIFPGGFLPSITAMNELMtRHTDFVVRNLFDMGPDYARTLAHWRQRFVHAWQEI 367
Cdd:pfam02353 161 MLLHTITGLHPDETsERGLPLKFIDKYIFPGGELPSISMIVESS-SEAGFTVEDVESLRPHYAKTLDLWAENLQANKDEA 239

                         250       260       270
                  ....*....|....*....|....*....|....
gi 556475800  368 EKLgFDERFRRMWLYYFGYCEAGFNARTISVVQL 401
Cdd:pfam02353 240 IAL-QSEEFYRMWMLYLTGCAVAFRIGYIDVHQF 272
 
Name Accession Description Interval E-value
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 129-401 2.08e-93

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 281.52  E-value: 2.08e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800  129 SRAQARENIAAHYDLGNTFYAHFLDRELLYSSALFTADEQDLTTAQQAKMARLCDQLALSEADHLLEIGTGWGAMAEYAA 208
Cdd:pfam02353   1 SKTRDAENIQAHYDLSNDFFALFLDPTMTYSCAYFERPDMTLEEAQQAKLDLILDKLGLKPGMTLLDIGCGWGGLMRRAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800  209 RHYGCRVTTTTLSQEQYVWATERIARAGLQDRVEVLLCDYRDLTGQYDKLVSIEMIEAVGQRYLPTFFRTCQARLRPGGR 288
Cdd:pfam02353  81 ERYDVNVVGLTLSKNQYKLARKRVAAEGLARKVEVLLQDYRDFDEPFDRIVSVGMFEHVGHENYDTFFKKLYNLLPPGGL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800  289 MAIQAITIQDQRYR-DYSKSVDFIQRYIFPGGFLPSITAMNELMtRHTDFVVRNLFDMGPDYARTLAHWRQRFVHAWQEI 367
Cdd:pfam02353 161 MLLHTITGLHPDETsERGLPLKFIDKYIFPGGELPSISMIVESS-SEAGFTVEDVESLRPHYAKTLDLWAENLQANKDEA 239

                         250       260       270
                  ....*....|....*....|....*....|....
gi 556475800  368 EKLgFDERFRRMWLYYFGYCEAGFNARTISVVQL 401
Cdd:pfam02353 240 IAL-QSEEFYRMWMLYLTGCAVAFRIGYIDVHQF 272
PRK11705 PRK11705
cyclopropane fatty acyl phospholipid synthase;
56-401 3.42e-87

cyclopropane fatty acyl phospholipid synthase;


Pssm-ID: 183282  Cd Length: 383  Bit Score: 269.41  E-value: 3.42e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800  56 DVQILTPAVYWRVLTGGSLAAAEAWMDGEWETAQLTPLLQILaLNGEVLGRLEKGFRLLgrpLERLRH-WTRRNSRAQAR 134
Cdd:PRK11705  38 DIQVHNPRFFKRVLQEGSLGLGESYMDGWWDCDRLDEFFSRV-LRAGLDEKLPHHLKDT---LRILRArLFNLQSKKRAW 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 135 ENIAAHYDLGNTFYAHFLDRELLYSSALFtADEQDLTTAQQAKMARLCDQLALSEADHLLEIGTGWGAMAEYAARHYGCR 214
Cdd:PRK11705 114 IVGKEHYDLGNDLFEAMLDPRMQYSCGYW-KDADTLEEAQEAKLDLICRKLQLKPGMRVLDIGCGWGGLARYAAEHYGVS 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 215 VTTTTLSQEQYVWATERiaRAGLQdrVEVLLCDYRDLTGQYDKLVSIEMIEAVGQRYLPTFFRTCQARLRPGGRMAIQAI 294
Cdd:PRK11705 193 VVGVTISAEQQKLAQER--CAGLP--VEIRLQDYRDLNGQFDRIVSVGMFEHVGPKNYRTYFEVVRRCLKPDGLFLLHTI 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 295 TiqdqRYRDYSKSVDFIQRYIFPGGFLPSITAMNELMTRHtdFVVRNLFDMGPDYARTLAHWRQRFVHAWQEIEKlGFDE 374
Cdd:PRK11705 269 G----SNKTDTNVDPWINKYIFPNGCLPSVRQIAQASEGL--FVMEDWHNFGADYDRTLMAWHENFEAAWPELAD-NYSE 341

                        330       340
                 ....*....|....*....|....*..
gi 556475800 375 RFRRMWLYYFGYCEAGFNARTISVVQL 401
Cdd:PRK11705 342 RFYRMWRYYLLSCAGAFRARDIQLWQV 368
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 139-293 1.00e-70

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 219.42  E-value: 1.00e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 139 AHYDLGNTFYAHFLDRELLYSSALFTADEQDLTTAQQAKMARLCDQLALSEADHLLEIGTGWGAMAEYAARHYGCRVTTT 218
Cdd:COG2230    1 HHYDLGNDFYRLFLDPTMTYSCAYFEDPDDTLEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556475800 219 TLSQEQYVWATERIARAGLQDRVEVLLCDYRDL--TGQYDKLVSIEMIEAVGQRYLPTFFRTCQARLRPGGRMAIQA 293
Cdd:COG2230   81 TLSPEQLEYARERAAEAGLADRVEVRLADYRDLpaDGQFDAIVSIGMFEHVGPENYPAYFAKVARLLKPGGRLLLHT 157
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 193-292 1.15e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 58.21  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 193 LLEIGTGWGAMAEYAARHYGCRVTTTTLSQEQYVWAtERIARAGLQDRVEVLLCDYRDLT----GQYDKLVSIEMIEAVG 268
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVALELA-RKAAAALLADNVEVLKGDAEELPpeadESFDVIISDPPLHHLV 80

                         90       100
                 ....*....|....*....|....
gi 556475800 269 QRYLPtFFRTCQARLRPGGRMAIQ 292
Cdd:cd02440   81 EDLAR-FLEEARRLLKPGGVLVLT 103
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
192-289 3.34e-03

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 38.55  E-value: 3.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800   192 HLLEIGTGWGA-MAEYAARHYGCRVTTTTLSQEQYVWATERIARAGLQDRVEVLlcdYRDLT-----GQYDKLVSIEMIE 265
Cdd:smart00828   2 RVLDFGCGYGSdLIDLAERHPHLQLHGYTISPEQAEVGRERIRALGLQGRIRIF---YRDSAkdpfpDTYDLVFGFEVIH 78

                           90       100
                   ....*....|....*....|....
gi 556475800   266 AVGQRYLptFFRTCQARLRPGGRM 289
Cdd:smart00828  79 HIKDKMD--LFSNISRHLKDGGHL 100
 
Name Accession Description Interval E-value
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 129-401 2.08e-93

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 281.52  E-value: 2.08e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800  129 SRAQARENIAAHYDLGNTFYAHFLDRELLYSSALFTADEQDLTTAQQAKMARLCDQLALSEADHLLEIGTGWGAMAEYAA 208
Cdd:pfam02353   1 SKTRDAENIQAHYDLSNDFFALFLDPTMTYSCAYFERPDMTLEEAQQAKLDLILDKLGLKPGMTLLDIGCGWGGLMRRAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800  209 RHYGCRVTTTTLSQEQYVWATERIARAGLQDRVEVLLCDYRDLTGQYDKLVSIEMIEAVGQRYLPTFFRTCQARLRPGGR 288
Cdd:pfam02353  81 ERYDVNVVGLTLSKNQYKLARKRVAAEGLARKVEVLLQDYRDFDEPFDRIVSVGMFEHVGHENYDTFFKKLYNLLPPGGL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800  289 MAIQAITIQDQRYR-DYSKSVDFIQRYIFPGGFLPSITAMNELMtRHTDFVVRNLFDMGPDYARTLAHWRQRFVHAWQEI 367
Cdd:pfam02353 161 MLLHTITGLHPDETsERGLPLKFIDKYIFPGGELPSISMIVESS-SEAGFTVEDVESLRPHYAKTLDLWAENLQANKDEA 239

                         250       260       270
                  ....*....|....*....|....*....|....
gi 556475800  368 EKLgFDERFRRMWLYYFGYCEAGFNARTISVVQL 401
Cdd:pfam02353 240 IAL-QSEEFYRMWMLYLTGCAVAFRIGYIDVHQF 272
PRK11705 PRK11705
cyclopropane fatty acyl phospholipid synthase;
56-401 3.42e-87

cyclopropane fatty acyl phospholipid synthase;


Pssm-ID: 183282  Cd Length: 383  Bit Score: 269.41  E-value: 3.42e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800  56 DVQILTPAVYWRVLTGGSLAAAEAWMDGEWETAQLTPLLQILaLNGEVLGRLEKGFRLLgrpLERLRH-WTRRNSRAQAR 134
Cdd:PRK11705  38 DIQVHNPRFFKRVLQEGSLGLGESYMDGWWDCDRLDEFFSRV-LRAGLDEKLPHHLKDT---LRILRArLFNLQSKKRAW 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 135 ENIAAHYDLGNTFYAHFLDRELLYSSALFtADEQDLTTAQQAKMARLCDQLALSEADHLLEIGTGWGAMAEYAARHYGCR 214
Cdd:PRK11705 114 IVGKEHYDLGNDLFEAMLDPRMQYSCGYW-KDADTLEEAQEAKLDLICRKLQLKPGMRVLDIGCGWGGLARYAAEHYGVS 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 215 VTTTTLSQEQYVWATERiaRAGLQdrVEVLLCDYRDLTGQYDKLVSIEMIEAVGQRYLPTFFRTCQARLRPGGRMAIQAI 294
Cdd:PRK11705 193 VVGVTISAEQQKLAQER--CAGLP--VEIRLQDYRDLNGQFDRIVSVGMFEHVGPKNYRTYFEVVRRCLKPDGLFLLHTI 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 295 TiqdqRYRDYSKSVDFIQRYIFPGGFLPSITAMNELMTRHtdFVVRNLFDMGPDYARTLAHWRQRFVHAWQEIEKlGFDE 374
Cdd:PRK11705 269 G----SNKTDTNVDPWINKYIFPNGCLPSVRQIAQASEGL--FVMEDWHNFGADYDRTLMAWHENFEAAWPELAD-NYSE 341

                        330       340
                 ....*....|....*....|....*..
gi 556475800 375 RFRRMWLYYFGYCEAGFNARTISVVQL 401
Cdd:PRK11705 342 RFYRMWRYYLLSCAGAFRARDIQLWQV 368
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 139-293 1.00e-70

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 219.42  E-value: 1.00e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 139 AHYDLGNTFYAHFLDRELLYSSALFTADEQDLTTAQQAKMARLCDQLALSEADHLLEIGTGWGAMAEYAARHYGCRVTTT 218
Cdd:COG2230    1 HHYDLGNDFYRLFLDPTMTYSCAYFEDPDDTLEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGV 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 556475800 219 TLSQEQYVWATERIARAGLQDRVEVLLCDYRDL--TGQYDKLVSIEMIEAVGQRYLPTFFRTCQARLRPGGRMAIQA 293
Cdd:COG2230   81 TLSPEQLEYARERAAEAGLADRVEVRLADYRDLpaDGQFDAIVSIGMFEHVGPENYPAYFAKVARLLKPGGRLLLHT 157
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 194-287 2.61e-15

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 71.06  E-value: 2.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800  194 LEIGTGWGAMAEYAARHYGCRVTTTTLSQEQYVWATERIARAGLqdRVEVLLCDYRDL---TGQYDKLVSIEMIEAVGQR 270
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLpfpDGSFDLVVSSGVLHHLPDP 79

                          90
                  ....*....|....*..
gi 556475800  271 YLPTFFRTCQARLRPGG 287
Cdd:pfam13649  80 DLEAALREIARVLKPGG 96
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 179-291 1.15e-11

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 61.93  E-value: 1.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 179 ARLCDQLALSEADHLLEIGTGWGAMAEYAARHyGCRVTTTTLSQEQYVWATERIARAGLqdRVEVLLCDYRDL---TGQY 255
Cdd:COG2226   12 EALLAALGLRPGARVLDLGCGTGRLALALAER-GARVTGVDISPEMLELARERAAEAGL--NVEFVVGDAEDLpfpDGSF 88

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 556475800 256 DKLVSIEMIEAVgqRYLPTFFRTCQARLRPGGRMAI 291
Cdd:COG2226   89 DLVISSFVLHHL--PDPERALAEIARVLKPGGRLVV 122
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 193-292 1.15e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 58.21  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 193 LLEIGTGWGAMAEYAARHYGCRVTTTTLSQEQYVWAtERIARAGLQDRVEVLLCDYRDLT----GQYDKLVSIEMIEAVG 268
Cdd:cd02440    2 VLDLGCGTGALALALASGPGARVTGVDISPVALELA-RKAAAALLADNVEVLKGDAEELPpeadESFDVIISDPPLHHLV 80

                         90       100
                 ....*....|....*....|....
gi 556475800 269 QRYLPtFFRTCQARLRPGGRMAIQ 292
Cdd:cd02440   81 EDLAR-FLEEARRLLKPGGVLVLT 103
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 176-291 1.74e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 58.11  E-value: 1.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 176 AKMARLCDQLALSEAdHLLEIGTGWGAMAEYAARHyGCRVTTTTLSQEQYVWATERIARAglqdRVEVLLCDYRDL---T 252
Cdd:COG2227   12 RRLAALLARLLPAGG-RVLDVGCGTGRLALALARR-GADVTGVDISPEALEIARERAAEL----NVDFVQGDLEDLpleD 85

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 556475800 253 GQYDKLVSIEMIEAVgqRYLPTFFRTCQARLRPGGRMAI 291
Cdd:COG2227   86 GSFDLVICSEVLEHL--PDPAALLRELARLLKPGGLLLL 122
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 185-287 2.74e-09

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 55.96  E-value: 2.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 185 LALSEADHLLEIGTGWG----AMAEYAARhyGCRVTTTTLSQEQYVWATERIARAGLQDRVEVLLCDYRD-----LTGQY 255
Cdd:COG4122   12 ARLLGAKRILEIGTGTGystlWLARALPD--DGRLTTIEIDPERAAIARENFARAGLADRIRLILGDALEvlprlADGPF 89

                         90       100       110
                 ....*....|....*....|....*....|..
gi 556475800 256 DkLVsieMIEAVGQRYlPTFFRTCQARLRPGG 287
Cdd:COG4122   90 D-LV---FIDADKSNY-PDYLELALPLLRPGG 116
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 178-302 3.76e-09

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 56.08  E-value: 3.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 178 MARLCDQLALSEADHLLEIGTGWGAMAEYAARHYGCRVTTTTLSQEQYVWATERIARAGLqDRVEVLLCDYRDL----TG 253
Cdd:COG0500   15 AALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGL-GNVEFLVADLAELdplpAE 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 556475800 254 QYDKLVSIEMIEAVGQRYLPTFFRTCQARLRPGGRMAIQAITIQDQRYR 302
Cdd:COG0500   94 SFDLVVAFGVLHHLPPEEREALLRELARALKPGGVLLLSASDAAAALSL 142
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 194-291 7.57e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 49.97  E-value: 7.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800  194 LEIGTGWGAMAEYAARhYGCRVTTTTLSQEQYVWATERIARAGLQDRVevllCDYRDLT---GQYDKLVSIEMIEAVgqR 270
Cdd:pfam08241   1 LDVGCGTGLLTELLAR-LGARVTGVDISPEMLELAREKAPREGLTFVV----GDAEDLPfpdNSFDLVLSSEVLHHV--E 73

                          90       100
                  ....*....|....*....|.
gi 556475800  271 YLPTFFRTCQARLRPGGRMAI 291
Cdd:pfam08241  74 DPERALREIARVLKPGGILII 94
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
189-292 3.94e-07

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 47.90  E-value: 3.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 189 EADHLLEIGTGWGAMAEY-AARHYGCRVTTTTLSQEqyvwATERiARAGLqDRVEVLLCDYRDLT--GQYDKLVSIEMIE 265
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALlAERFPGARVTGVDLSPE----MLAR-ARARL-PNVRFVVADLRDLDppEPFDLVVSNAALH 74

                         90       100
                 ....*....|....*....|....*..
gi 556475800 266 AVGQRylPTFFRTCQARLRPGGRMAIQ 292
Cdd:COG4106   75 WLPDH--AALLARLAAALAPGGVLAVQ 99
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 194-288 3.82e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 42.35  E-value: 3.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800  194 LEIGTGWGAMAEYAARHY-GCRVTTTTLSQEQYVWATERIARAGLQD--RVEVLLCDYRDLTG-QYDKLVSIEMIEAVgq 269
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALpGLEYTGLDISPAALEAARERLAALGLLNavRVELFQLDLGELDPgSFDVVVASNVLHHL-- 78

                          90
                  ....*....|....*....
gi 556475800  270 RYLPTFFRTCQARLRPGGR 288
Cdd:pfam08242  79 ADPRAVLRNIRRLLKPGGV 97
PLN02244 PLN02244
tocopherol O-methyltransferase
 188-291 4.20e-05

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 45.12  E-value: 4.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 188 SEADHLLEIGTGWGAMAEYAARHYGCRVTTTTLSQEQYVWATERIARAGLQDRVEVLLCDYRDL---TGQYDKLVSIEMI 264
Cdd:PLN02244 117 KRPKRIVDVGCGIGGSSRYLARKYGANVKGITLSPVQAARANALAAAQGLSDKVSFQVADALNQpfeDGQFDLVWSMESG 196

                         90       100
                 ....*....|....*....|....*....
gi 556475800 265 EAV--GQRYLPTFFRTCqarlRPGGRMAI 291
Cdd:PLN02244 197 EHMpdKRKFVQELARVA----APGGRIII 221
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
191-296 5.58e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 44.26  E-value: 5.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 191 DHLLEIGTGWGAMAEYAARHYGCRVTTTTLSQEQYVWATERIARAGLQDRVEVLLCDYRDLT--GQYDKLVSiEMIE--A 266
Cdd:COG4076   37 DVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRITVINADATDLDlpEKADVIIS-EMLDtaL 115

                         90       100       110
                 ....*....|....*....|....*....|
gi 556475800 267 VGQRYLPTFFRTCQARLRPGGRMAIQAITI 296
Cdd:COG4076  116 LDEGQVPILNHARKRLLKPGGRIIPERITN 145
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 178-291 8.57e-05

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 43.15  E-value: 8.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 178 MARLCDQLALSEADHLLEIGTGWGAMAEYAARHyGCRVTTTTLSQEQYVWATERIARAGLqDRVEVLlcdYRDLT----- 252
Cdd:COG2518   55 VARMLEALDLKPGDRVLEIGTGSGYQAAVLARL-AGRVYSVERDPELAERARERLAALGY-DNVTVR---VGDGAlgwpe 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 556475800 253 -GQYDKLVsiemIEAVGQRYLPTFFrtcqARLRPGGRMAI 291
Cdd:COG2518  130 hAPFDRII----VTAAAPEVPEALL----EQLAPGGRLVA 161
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
132-305 3.10e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 41.52  E-value: 3.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 132 QARENIAAHYDLGNTFYAHFLDRELLYSsalftadeqdlttAQQAKMARLCDQLALSEADHLLEIGTGWGAMAEYAARHY 211
Cdd:COG4976    2 ALDAYVEALFDQYADSYDAALVEDLGYE-------------APALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRG 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 212 GcRVTTTTLSQEqyvwATERIARAGLQDRVEVL-LCDYRDLTGQYDKLVSIEMIEAVGQryLPTFFRTCQARLRPGGRMA 290
Cdd:COG4976   69 Y-RLTGVDLSEE----MLAKAREKGVYDRLLVAdLADLAEPDGRFDLIVAADVLTYLGD--LAAVFAGVARALKPGGLFI 141

                        170
                 ....*....|....*
gi 556475800 291 IQAITIQDQRYRDYS 305
Cdd:COG4976  142 FSVEDADGSGRYAHS 156
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 187-291 1.21e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 40.13  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 187 LSEADHLLEIGTGWGAMAEY-AARHYGCRVTTTTLSQEQYVWATERIARAGLQDRVEVLLCDYRDL-----TGQYDKLVS 260
Cdd:COG4123   35 VKKGGRVLDLGTGTGVIALMlAQRSPGARITGVEIQPEAAELARRNVALNGLEDRITVIHGDLKEFaaelpPGSFDLVVS 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 556475800 261 IE--MIEAVGQ----------RY-----LPTFFRTCQARLRPGGRMAI 291
Cdd:COG4123  115 NPpyFKAGSGRkspdearaiaRHedaltLEDLIRAAARLLKPGGRFAL 162
SpeE COG0421
Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];
185-294 1.32e-03

Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];


Pssm-ID: 440190 [Multi-domain]  Cd Length: 195  Bit Score: 39.81  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 185 LALSEADHLLEIGTGWGAMAEYAARHYG-CRVTT-------TTLSQEQYvwateRIARAGLQD-RVEVLLCD---Y-RDL 251
Cdd:COG0421   33 LFHPNPKRVLIIGGGDGGLARELLKHPPvERVDVveidpevVELAREYF-----PLLAPAFDDpRLRVVIGDgraFlREA 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 556475800 252 TGQYDkLVSIEMIEAVG---QRYLPTFFRTCQARLRPGGRMAIQAI 294
Cdd:COG0421  108 EESYD-VIIVDLTDPVGpaeGLFTREFYEDCRRALKPGGVLVVNLG 152
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
192-289 3.34e-03

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 38.55  E-value: 3.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800   192 HLLEIGTGWGA-MAEYAARHYGCRVTTTTLSQEQYVWATERIARAGLQDRVEVLlcdYRDLT-----GQYDKLVSIEMIE 265
Cdd:smart00828   2 RVLDFGCGYGSdLIDLAERHPHLQLHGYTISPEQAEVGRERIRALGLQGRIRIF---YRDSAkdpfpDTYDLVFGFEVIH 78

                           90       100
                   ....*....|....*....|....
gi 556475800   266 AVGQRYLptFFRTCQARLRPGGRM 289
Cdd:smart00828  79 HIKDKMD--LFSNISRHLKDGGHL 100
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 193-292 3.38e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 38.18  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800  193 LLEIGTGWGAMAEYaARHYGCRVTTTtlsqEQYVWATERIARAGLQDRVEVLLCDYrdLTGQYDKLVSIEMIEAVgqRYL 272
Cdd:pfam13489  26 VLDFGCGTGIFLRL-LRAQGFSVTGV----DPSPIAIERALLNVRFDQFDEQEAAV--PAGKFDVIVAREVLEHV--PDP 96

                          90       100
                  ....*....|....*....|
gi 556475800  273 PTFFRTCQARLRPGGRMAIQ 292
Cdd:pfam13489  97 PALLRQIAALLKPGGLLLLS 116
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 181-289 4.12e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 38.25  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 181 LCDQLALSEADHLLEIGTGWGAMAEYAARHY-GCRVTTTTLSqEQYVWATER-IARAGLQDrVEVLLCDYRD--LTGQYD 256
Cdd:COG2813   41 LLEHLPEPLGGRVLDLGCGYGVIGLALAKRNpEARVTLVDVN-ARAVELARAnAAANGLEN-VEVLWSDGLSgvPDGSFD 118

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 556475800 257 KLVS-------IEMIEAVGQRylptFFRTCQARLRPGGRM 289
Cdd:COG2813  119 LILSnppfhagRAVDKEVAHA----LIADAARHLRPGGEL 154
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 179-291 9.96e-03

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 37.30  E-value: 9.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556475800 179 ARLCDQLALSEADHLLEIGTGWGamaeyaarhYGCRVTTTTLSQEQYVWATERI------ARAGLQ----DRVEVLLCD- 247
Cdd:PRK13942  66 AIMCELLDLKEGMKVLEIGTGSG---------YHAAVVAEIVGKSGKVVTIERIpelaekAKKTLKklgyDNVEVIVGDg 136

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 556475800 248 ---YRDLTgQYDKLVsiemIEAVGQRYLPTFFRtcqaRLRPGGRMAI 291
Cdd:PRK13942 137 tlgYEENA-PYDRIY----VTAAGPDIPKPLIE----QLKDGGIMVI 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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