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MULTISPECIES: molecular chaperone HtpG [Enterobacter]
Protein Classification
Hsp90 family chaperone protein ( domain architecture ID 11480452 )
Hsp90 (heat shock protein 90) family chaperone protein, such as molecular chaperone HtpG (high-temperature protein G) that facilitates the folding and conformational changes of a wide array of proteins
List of domain hits
Name
Accession
Description
Interval
E-value
PRK05218
PRK05218 heat shock protein 90; Provisional
4-624
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 1122.51
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 4 Q ET RG FQ S EVKQLLHLMIHSLYSNKEIFLRELISNASDA A DKLRF R AL SN P D LYEGDG E L RV R V SF N KE N RTLTI A DNGI 83
Cdd:PRK05218 3 M ET GE FQ A EVKQLLHLMIHSLYSNKEIFLRELISNASDA I DKLRF E AL TD P A LYEGDG D L KI R I SF D KE A RTLTI S DNGI 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 84 GM N R D EVI DH LGTIAKSGTK A FLE SMGS DQ A KDSQLIGQFGVGFYSAF I VADKVTV R TR A AG DS AE n G V L WES K GEGEYT 163
Cdd:PRK05218 83 GM T R E EVI EN LGTIAKSGTK E FLE KLKG DQ K KDSQLIGQFGVGFYSAF M VADKVTV I TR S AG PA AE - A V R WES D GEGEYT 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 164 VDD I T K AD RGTEITLHL R E G ED D FL ND WR V RSII S KYSD H I AL P VEI EK Q E ekdgetvvs W E K IN K A Q ALWTR N KSEI K D 243
Cdd:PRK05218 162 IEE I E K EE RGTEITLHL K E D ED E FL DE WR I RSII K KYSD F I PV P IKL EK E E --------- E E T IN S A S ALWTR S KSEI T D 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 244 D EY N EFYKH I AHDF T DPL T W S HN R VEG KQ EYT S LLYIP AQ AP W D MW NRD H K H GLKLYV Q RVFIMDDAE QFM P N YLRFV R G 323
Cdd:PRK05218 233 E EY K EFYKH L AHDF D DPL F W I HN N VEG PF EYT G LLYIP KK AP F D LF NRD R K G GLKLYV K RVFIMDDAE ELL P E YLRFV K G 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 324 L IDS N DLPLNVSREILQ DST V TRNL R N A L TK RA L QM LEKLAK D D A EKY QT FWK Q FG L VLKEG PA ED T AN V E TI AKLLRFA 403
Cdd:PRK05218 313 V IDS E DLPLNVSREILQ EDR V VKKI R K A I TK KV L DE LEKLAK N D R EKY EK FWK E FG P VLKEG LY ED F AN R E KL AKLLRFA 392
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 404 STH tds SAQT VSL E EYV S RMKEGQ E KIYYIT A DS YA AAK S SPHLEL LR KKGIEVLLL S D R IDE WMMN YL T EFDGK A F Q SV 483
Cdd:PRK05218 393 STH --- EGKY VSL A EYV E RMKEGQ K KIYYIT G DS RE AAK N SPHLEL FK KKGIEVLLL T D P IDE FWIS YL E EFDGK P F K SV 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 484 A KA D ESID K LAD E VD E SAK EAE KALE P FV ER V K TL LGD R VK E VR FT HRLTD T PA IVTT D ADE MSTQM A KL FA AAGQ A VPE 563
Cdd:PRK05218 470 A RG D LDLG K EDE E EK E EKE EAE EEFK P LL ER L K EA LGD K VK D VR LS HRLTD S PA CLVA D EGD MSTQM E KL LK AAGQ E VPE 549
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556480674 564 V K Y I F E L NP D HPLVK RA AD TQ DEA R F AEWV ELL L DQ S LLAE R G T LEDP NL F I KR V N A LLL A 624
Cdd:PRK05218 550 S K P I L E I NP N HPLVK KL AD EA DEA K F KDLA ELL Y DQ A LLAE G G S LEDP AA F V KR L N E LLL K 610
Name
Accession
Description
Interval
E-value
PRK05218
PRK05218 heat shock protein 90; Provisional
4-624
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 1122.51
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 4 Q ET RG FQ S EVKQLLHLMIHSLYSNKEIFLRELISNASDA A DKLRF R AL SN P D LYEGDG E L RV R V SF N KE N RTLTI A DNGI 83
Cdd:PRK05218 3 M ET GE FQ A EVKQLLHLMIHSLYSNKEIFLRELISNASDA I DKLRF E AL TD P A LYEGDG D L KI R I SF D KE A RTLTI S DNGI 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 84 GM N R D EVI DH LGTIAKSGTK A FLE SMGS DQ A KDSQLIGQFGVGFYSAF I VADKVTV R TR A AG DS AE n G V L WES K GEGEYT 163
Cdd:PRK05218 83 GM T R E EVI EN LGTIAKSGTK E FLE KLKG DQ K KDSQLIGQFGVGFYSAF M VADKVTV I TR S AG PA AE - A V R WES D GEGEYT 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 164 VDD I T K AD RGTEITLHL R E G ED D FL ND WR V RSII S KYSD H I AL P VEI EK Q E ekdgetvvs W E K IN K A Q ALWTR N KSEI K D 243
Cdd:PRK05218 162 IEE I E K EE RGTEITLHL K E D ED E FL DE WR I RSII K KYSD F I PV P IKL EK E E --------- E E T IN S A S ALWTR S KSEI T D 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 244 D EY N EFYKH I AHDF T DPL T W S HN R VEG KQ EYT S LLYIP AQ AP W D MW NRD H K H GLKLYV Q RVFIMDDAE QFM P N YLRFV R G 323
Cdd:PRK05218 233 E EY K EFYKH L AHDF D DPL F W I HN N VEG PF EYT G LLYIP KK AP F D LF NRD R K G GLKLYV K RVFIMDDAE ELL P E YLRFV K G 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 324 L IDS N DLPLNVSREILQ DST V TRNL R N A L TK RA L QM LEKLAK D D A EKY QT FWK Q FG L VLKEG PA ED T AN V E TI AKLLRFA 403
Cdd:PRK05218 313 V IDS E DLPLNVSREILQ EDR V VKKI R K A I TK KV L DE LEKLAK N D R EKY EK FWK E FG P VLKEG LY ED F AN R E KL AKLLRFA 392
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 404 STH tds SAQT VSL E EYV S RMKEGQ E KIYYIT A DS YA AAK S SPHLEL LR KKGIEVLLL S D R IDE WMMN YL T EFDGK A F Q SV 483
Cdd:PRK05218 393 STH --- EGKY VSL A EYV E RMKEGQ K KIYYIT G DS RE AAK N SPHLEL FK KKGIEVLLL T D P IDE FWIS YL E EFDGK P F K SV 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 484 A KA D ESID K LAD E VD E SAK EAE KALE P FV ER V K TL LGD R VK E VR FT HRLTD T PA IVTT D ADE MSTQM A KL FA AAGQ A VPE 563
Cdd:PRK05218 470 A RG D LDLG K EDE E EK E EKE EAE EEFK P LL ER L K EA LGD K VK D VR LS HRLTD S PA CLVA D EGD MSTQM E KL LK AAGQ E VPE 549
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556480674 564 V K Y I F E L NP D HPLVK RA AD TQ DEA R F AEWV ELL L DQ S LLAE R G T LEDP NL F I KR V N A LLL A 624
Cdd:PRK05218 550 S K P I L E I NP N HPLVK KL AD EA DEA K F KDLA ELL Y DQ A LLAE G G S LEDP AA F V KR L N E LLL K 610
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
4-624
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 1052.79
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 4 Q ET RG FQ S EVKQLL H LMIHSLYSNKEIFLRELISNASDA A DKLRF R AL SN P D L Y E G DG E L RV R VSFN KE NR TLTI A DNGI 83
Cdd:COG0326 3 K ET GE FQ A EVKQLL D LMIHSLYSNKEIFLRELISNASDA I DKLRF L AL TD P E L K E E DG D L KI R IEVD KE AK TLTI S DNGI 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 84 GM N R D EVI DH LGTIAKSGT KA FLE SMGS DQ A KDS Q LIGQFGVGFYSAF I VADKV T V R TR A AG DS AE n G V L WES K G E GEYT 163
Cdd:COG0326 83 GM T R E EVI EN LGTIAKSGT RE FLE KLKG DQ K KDS D LIGQFGVGFYSAF M VADKV E V V TR S AG ED AE - A V R WES D G D GEYT 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 164 VDDIT KA D RGTEITLHL R E GEDD FL ND WR V R S II S KYSD H I AL P VEI E KQ EE KDG E tvvs W E K IN K A Q ALWTR N KSEI K D 243
Cdd:COG0326 162 IEEAE KA E RGTEITLHL K E DAEE FL EE WR L R E II K KYSD F I PV P IKM E GE EE ETE E ---- D E T IN S A T ALWTR S KSEI T D 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 244 D EY N EFYKH IA HDF T DPL T W S H NR VEG KQ EYT S LLYIP AQ AP W D MWN RD H K H G L KLYV Q RVFIMDDAE QFM P N YLRFVRG 323
Cdd:COG0326 238 E EY K EFYKH LF HDF E DPL F W I H LN VEG PF EYT G LLYIP KK AP F D LYD RD R K G G I KLYV K RVFIMDDAE DLL P E YLRFVRG 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 324 LI DS N DLPLNVSREILQ DSTVTRNL R N A L TK RA L QM LEKLAK D D A EKY QT FWK Q FGLVLKEG PA ED TA N V E T IA K LLRF A 403
Cdd:COG0326 318 VV DS P DLPLNVSREILQ EDRQLKKI R K A I TK KV L DE LEKLAK N D R EKY EK FWK E FGLVLKEG AL ED FK N R E K IA D LLRF E 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 404 ST HTD ssa QT V S L E EYV S RMKEGQ E KIYYIT AD S YA AA KS SPHLE LLRK KGIEVLLL S D R IDE WMMNY L T EFDGK A F Q SV 483
Cdd:COG0326 398 ST KEG --- GY V T L A EYV E RMKEGQ K KIYYIT GE S RE AA EQ SPHLE IFKA KGIEVLLL T D P IDE FLISH L E EFDGK K F K SV 474
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 484 AKA D ESI DKL ADE vd ESAK E A E KALE P FV ER V K TL LGD R VK E VR FTH RLTD T PA IVTT D ADE MS TQ M A K LFA A A GQ AV PE 563
Cdd:COG0326 475 DSG D LDL DKL EEK -- KESE E E E EEFK P LL ER F K EA LGD K VK D VR VSA RLTD S PA CLVA D EGD MS RR M E K MLK A M GQ DM PE 552
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556480674 564 V K Y I F E L NP D HPLVK RA A DTQ DE AR F AEWV ELL L DQ S LLAE R G T LEDP NL F I KR V N A LL LA 624
Cdd:COG0326 553 A K P I L E I NP N HPLVK KL A AEE DE EL F KDLA ELL Y DQ A LLAE G G L LEDP AA F V KR L N K LL EK 613
HSP90
pfam00183 Hsp90 protein;
186-622
7.13e-149
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 440.07
E-value: 7.13e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 186 DF L NDWRVRSIIS KYS DH I AL P VEI -- EK Q EE KD ------------------------------------- G ETV VS WE K 226
Cdd:pfam00183 1 EY L EEKKIKELVK KYS EF I NF P IYL wv EK E EE VE vpdeeeeeeeeeeeeedddpkveeedeeeekkktkkv K ETV WE WE L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 227 I NK AQAL WTRN KS E IKDD EY N EFYK HIAH D FT DPL TWS H NR VEG KQ E YT SLL Y IP AQ AP W D MWNRDH K H - GL KLYV Q RVF 305
Cdd:pfam00183 81 L NK TKPI WTRN PK E VTEE EY A EFYK SLSK D WE DPL AVK H FS VEG EV E FK SLL F IP KR AP F D LFENKK K K n NI KLYV R RVF 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 306 I M DD A E QFM P N YL R FV R G LI DS N DLPLNVSRE I LQ DSTVTRNLRNA L TKR AL Q M LEKL A KDD a E K Y QT FWK Q FG LV LK E G 385
Cdd:pfam00183 161 I T DD F E DLI P E YL N FV K G VV DS D DLPLNVSRE T LQ QNKILKVIKKK L VRK AL D M FKEI A EEK - E D Y KK FWK E FG KN LK L G 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 386 PA ED TA N VETI AKLLRF A S TH td S SAQTV SL EE YVSRMKEGQ EK IYYIT AD S YAAAKS SP H LE L L R KKG I EVL L L S D R ID 465
Cdd:pfam00183 240 II ED SS N RNKL AKLLRF Y S SK -- S GDELT SL DD YVSRMKEGQ KH IYYIT GE S KEEVEN SP F LE R L K KKG Y EVL Y L T D P ID 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 466 E WMMNY L T EFDGK AFQS VAK ADESIDKLAD E v DESAK E AE K AL EP FVERV K TL LGD R V KE V RFTH RL T D T P AIVT T DADE 545
Cdd:pfam00183 318 E YAVQQ L K EFDGK KLVN VAK EGLELEEDEE E - KKKDE E LK K EF EP LTKWL K DV LGD K V EK V VVSN RL V D S P CVLV T SQYG 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 546 M S TQ M AKLFA A ag QA VPE --------- V K YIF E L NP D HP LV K ---- R AADTQ D EARFAEWVE LL LDQS LL AERGT LEDP N 612
Cdd:pfam00183 397 W S AN M ERIMK A -- QA LRK dssmssyms S K KTL E I NP R HP II K ellk R VEADK D DKTAKDLAL LL YETA LL RSGFS LEDP A 474
490
....*....|
gi 556480674 613 L F IK R VNAL L 622
Cdd:pfam00183 475 S F AS R IYRM L 484
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
14-204
9.11e-107
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 319.85
E-value: 9.11e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 14 K QLL H L M IHSLYSNKEIFLRELISNASDA A DKLR FRA L SN P D L YEG D G EL RV R V S FN KENRTLTI A D N GIGM NRD E V I DH 93
Cdd:cd16927 1 N QLL D L I IHSLYSNKEIFLRELISNASDA L DKLR YLS L TD P S L LDD D P EL EI R I S PD KENRTLTI S D T GIGM TKE E L I NN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 94 LGTIA K SGTKAFLE SMGSD q AKDS Q LIGQFGVGFYSAF I VADKVTV R T RA AGD S ae N G VL WES K G E G E YT VDDITKA - D R 172
Cdd:cd16927 81 LGTIA R SGTKAFLE ALQEG - AKDS D LIGQFGVGFYSAF M VADKVTV T T KS AGD D -- E G YR WES D G G G S YT IEEAEGE l G R 157
170 180 190
....*....|....*....|....*....|..
gi 556480674 173 GT E ITLHL R E GEDD FL NDW R VRSIIS KYSD H I 204
Cdd:cd16927 158 GT K ITLHL K E DAKE FL EEA R IKELVK KYSD F I 189
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
27-181
1.12e-11
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 61.90
E-value: 1.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 27 NKEIF LR ELI SN AS D A A D K LRFR alsnpdlyeg D G ELR V RVSFNKENRTL T IA DNG I G MN r D E VIDHL gtiaksgtkaf L 106
Cdd:smart00387 1 GDPDR LR QVL SN LL D N A I K YTPE ---------- G G RIT V TLERDGDHVEI T VE DNG P G IP - P E DLEKI ----------- F 58
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556480674 107 E SMGS d QA K D S QL IG QF G V G FYSAFIVADKV tvrtraagdsaengvlweskg E GE YT V DD it KADR GT EI T LH L R 181
Cdd:smart00387 59 E PFFR - TD K R S RK IG GT G L G LSIVKKLVELH --------------------- G GE IS V ES -- EPGG GT TF T IT L P 109
Name
Accession
Description
Interval
E-value
PRK05218
PRK05218 heat shock protein 90; Provisional
4-624
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 1122.51
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 4 Q ET RG FQ S EVKQLLHLMIHSLYSNKEIFLRELISNASDA A DKLRF R AL SN P D LYEGDG E L RV R V SF N KE N RTLTI A DNGI 83
Cdd:PRK05218 3 M ET GE FQ A EVKQLLHLMIHSLYSNKEIFLRELISNASDA I DKLRF E AL TD P A LYEGDG D L KI R I SF D KE A RTLTI S DNGI 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 84 GM N R D EVI DH LGTIAKSGTK A FLE SMGS DQ A KDSQLIGQFGVGFYSAF I VADKVTV R TR A AG DS AE n G V L WES K GEGEYT 163
Cdd:PRK05218 83 GM T R E EVI EN LGTIAKSGTK E FLE KLKG DQ K KDSQLIGQFGVGFYSAF M VADKVTV I TR S AG PA AE - A V R WES D GEGEYT 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 164 VDD I T K AD RGTEITLHL R E G ED D FL ND WR V RSII S KYSD H I AL P VEI EK Q E ekdgetvvs W E K IN K A Q ALWTR N KSEI K D 243
Cdd:PRK05218 162 IEE I E K EE RGTEITLHL K E D ED E FL DE WR I RSII K KYSD F I PV P IKL EK E E --------- E E T IN S A S ALWTR S KSEI T D 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 244 D EY N EFYKH I AHDF T DPL T W S HN R VEG KQ EYT S LLYIP AQ AP W D MW NRD H K H GLKLYV Q RVFIMDDAE QFM P N YLRFV R G 323
Cdd:PRK05218 233 E EY K EFYKH L AHDF D DPL F W I HN N VEG PF EYT G LLYIP KK AP F D LF NRD R K G GLKLYV K RVFIMDDAE ELL P E YLRFV K G 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 324 L IDS N DLPLNVSREILQ DST V TRNL R N A L TK RA L QM LEKLAK D D A EKY QT FWK Q FG L VLKEG PA ED T AN V E TI AKLLRFA 403
Cdd:PRK05218 313 V IDS E DLPLNVSREILQ EDR V VKKI R K A I TK KV L DE LEKLAK N D R EKY EK FWK E FG P VLKEG LY ED F AN R E KL AKLLRFA 392
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 404 STH tds SAQT VSL E EYV S RMKEGQ E KIYYIT A DS YA AAK S SPHLEL LR KKGIEVLLL S D R IDE WMMN YL T EFDGK A F Q SV 483
Cdd:PRK05218 393 STH --- EGKY VSL A EYV E RMKEGQ K KIYYIT G DS RE AAK N SPHLEL FK KKGIEVLLL T D P IDE FWIS YL E EFDGK P F K SV 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 484 A KA D ESID K LAD E VD E SAK EAE KALE P FV ER V K TL LGD R VK E VR FT HRLTD T PA IVTT D ADE MSTQM A KL FA AAGQ A VPE 563
Cdd:PRK05218 470 A RG D LDLG K EDE E EK E EKE EAE EEFK P LL ER L K EA LGD K VK D VR LS HRLTD S PA CLVA D EGD MSTQM E KL LK AAGQ E VPE 549
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556480674 564 V K Y I F E L NP D HPLVK RA AD TQ DEA R F AEWV ELL L DQ S LLAE R G T LEDP NL F I KR V N A LLL A 624
Cdd:PRK05218 550 S K P I L E I NP N HPLVK KL AD EA DEA K F KDLA ELL Y DQ A LLAE G G S LEDP AA F V KR L N E LLL K 610
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
4-624
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 1052.79
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 4 Q ET RG FQ S EVKQLL H LMIHSLYSNKEIFLRELISNASDA A DKLRF R AL SN P D L Y E G DG E L RV R VSFN KE NR TLTI A DNGI 83
Cdd:COG0326 3 K ET GE FQ A EVKQLL D LMIHSLYSNKEIFLRELISNASDA I DKLRF L AL TD P E L K E E DG D L KI R IEVD KE AK TLTI S DNGI 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 84 GM N R D EVI DH LGTIAKSGT KA FLE SMGS DQ A KDS Q LIGQFGVGFYSAF I VADKV T V R TR A AG DS AE n G V L WES K G E GEYT 163
Cdd:COG0326 83 GM T R E EVI EN LGTIAKSGT RE FLE KLKG DQ K KDS D LIGQFGVGFYSAF M VADKV E V V TR S AG ED AE - A V R WES D G D GEYT 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 164 VDDIT KA D RGTEITLHL R E GEDD FL ND WR V R S II S KYSD H I AL P VEI E KQ EE KDG E tvvs W E K IN K A Q ALWTR N KSEI K D 243
Cdd:COG0326 162 IEEAE KA E RGTEITLHL K E DAEE FL EE WR L R E II K KYSD F I PV P IKM E GE EE ETE E ---- D E T IN S A T ALWTR S KSEI T D 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 244 D EY N EFYKH IA HDF T DPL T W S H NR VEG KQ EYT S LLYIP AQ AP W D MWN RD H K H G L KLYV Q RVFIMDDAE QFM P N YLRFVRG 323
Cdd:COG0326 238 E EY K EFYKH LF HDF E DPL F W I H LN VEG PF EYT G LLYIP KK AP F D LYD RD R K G G I KLYV K RVFIMDDAE DLL P E YLRFVRG 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 324 LI DS N DLPLNVSREILQ DSTVTRNL R N A L TK RA L QM LEKLAK D D A EKY QT FWK Q FGLVLKEG PA ED TA N V E T IA K LLRF A 403
Cdd:COG0326 318 VV DS P DLPLNVSREILQ EDRQLKKI R K A I TK KV L DE LEKLAK N D R EKY EK FWK E FGLVLKEG AL ED FK N R E K IA D LLRF E 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 404 ST HTD ssa QT V S L E EYV S RMKEGQ E KIYYIT AD S YA AA KS SPHLE LLRK KGIEVLLL S D R IDE WMMNY L T EFDGK A F Q SV 483
Cdd:COG0326 398 ST KEG --- GY V T L A EYV E RMKEGQ K KIYYIT GE S RE AA EQ SPHLE IFKA KGIEVLLL T D P IDE FLISH L E EFDGK K F K SV 474
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 484 AKA D ESI DKL ADE vd ESAK E A E KALE P FV ER V K TL LGD R VK E VR FTH RLTD T PA IVTT D ADE MS TQ M A K LFA A A GQ AV PE 563
Cdd:COG0326 475 DSG D LDL DKL EEK -- KESE E E E EEFK P LL ER F K EA LGD K VK D VR VSA RLTD S PA CLVA D EGD MS RR M E K MLK A M GQ DM PE 552
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 556480674 564 V K Y I F E L NP D HPLVK RA A DTQ DE AR F AEWV ELL L DQ S LLAE R G T LEDP NL F I KR V N A LL LA 624
Cdd:COG0326 553 A K P I L E I NP N HPLVK KL A AEE DE EL F KDLA ELL Y DQ A LLAE G G L LEDP AA F V KR L N K LL EK 613
PTZ00272
PTZ00272 heat shock protein 83 kDa (Hsp83); Provisional
5-622
1.22e-170
heat shock protein 83 kDa (Hsp83); Provisional
Pssm-ID: 240341
Cd Length: 701
Bit Score: 502.67
E-value: 1.22e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 5 ET RG FQ S E VK QL LH L M I HSL YSNKEIFLRELISNASDA A DK L R FRA L SN P DLYEGDGE L RV RV SFN KEN R TLT IA DNGIG 84
Cdd:PTZ00272 3 ET FA FQ A E IN QL MS L I I NTF YSNKEIFLRELISNASDA C DK I R YQS L TD P SVLGESPR L CI RV VPD KEN K TLT VE DNGIG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 85 M NRDEVIDH LGTIA K SGTKAF L E SM gs DQAK D SQL IGQFGVGFYSA FI VAD K VTV RTRAAG D SA eng VL WES KGE G EY T V 164
Cdd:PTZ00272 83 M TKADLVNN LGTIA R SGTKAF M E AL -- EAGG D MSM IGQFGVGFYSA YL VAD R VTV TSKNNS D ES --- YV WES SAG G TF T I 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 165 DDITKA D -- RGT E ITLHL R E GEDDF L NDW R VRSI I S K Y S DH I ALPV E -- I EK -------------------------- Q E 214
Cdd:PTZ00272 158 TSTPES D mk RGT R ITLHL K E DQMEY L EPR R LKEL I K K H S EF I GYDI E lm V EK ttekevtdedeedtkkadedgeepkv E E 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 215 E K D G ------------ E TVVSW E KI NK AQA LWTR NKSEIKDD EY NE FYK H I AH D FT DP LTWS H NR VEG KQ E YT S LLYI P A 282
Cdd:PTZ00272 238 V K E G degkkkktkkvk E VTKEY E VQ NK HKP LWTR DPKDVTKE EY AA FYK A I SN D WE DP AATK H FS VEG QL E FR S IMFV P K 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 283 Q AP W DM WNRDH K - HGL KLYV Q RVFIMD DA E QFM P NY L R FV R G LI DS N DLPLN V SRE I LQ DSTVTRNL R NALT K RA L Q M LE 361
Cdd:PTZ00272 318 R AP F DM FEPNK K r NNI KLYV R RVFIMD NC E DLC P DW L G FV K G VV DS E DLPLN I SRE N LQ QNKILKVI R KNIV K KC L E M FD 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 362 KL A k DDA E K Y QT F WK QFG LVL K E G PA EDTAN VETIAK LLRF A S th T D S SAQTVS L EE YV S RMK E GQ EK IYYIT A DS YAAA 441
Cdd:PTZ00272 398 EV A - ENK E D Y KQ F YE QFG KNI K L G IH EDTAN RKKLME LLRF Y S -- T E S GEEMTT L KD YV T RMK A GQ KS IYYIT G DS KKKL 474
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 442 KS SP HL E LL R KK G I EVL LLSDR IDE WM M NYLTE F DG K A F QSVA K ad E SIDKLAD E VDESAK E A EK - A L E PFVERV K TL LG 520
Cdd:PTZ00272 475 ET SP FI E QA R RR G L EVL FMTEP IDE YV M QQVKD F ED K K F ACLT K -- E GVHFEES E EEKQQR E E EK a A C E KLCKTM K EV LG 552
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 521 D R V KE V RFTH RL TDT P A I VT T DADEM S TQ M AKLF aa AG QA VPE -------- V K YIF ELNP D HP LV K R ----- A AD TQ D E A 587
Cdd:PTZ00272 553 D K V EK V IVSE RL STS P C I LV T SEFGW S AH M EQIM -- RN QA LRD ssmaqymm S K KTM ELNP R HP II K E lrrrv G AD EN D K A 630
650 660 670
....*....|....*....|....*....|....*
gi 556480674 588 r FAEW V E LL L D Q SLL AERGT LEDP NLFIK R V N ALL 622
Cdd:PTZ00272 631 - VKDL V F LL F D T SLL TSGFQ LEDP TGYAE R I N RMI 664
HSP90
pfam00183 Hsp90 protein;
186-622
7.13e-149
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 440.07
E-value: 7.13e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 186 DF L NDWRVRSIIS KYS DH I AL P VEI -- EK Q EE KD ------------------------------------- G ETV VS WE K 226
Cdd:pfam00183 1 EY L EEKKIKELVK KYS EF I NF P IYL wv EK E EE VE vpdeeeeeeeeeeeeedddpkveeedeeeekkktkkv K ETV WE WE L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 227 I NK AQAL WTRN KS E IKDD EY N EFYK HIAH D FT DPL TWS H NR VEG KQ E YT SLL Y IP AQ AP W D MWNRDH K H - GL KLYV Q RVF 305
Cdd:pfam00183 81 L NK TKPI WTRN PK E VTEE EY A EFYK SLSK D WE DPL AVK H FS VEG EV E FK SLL F IP KR AP F D LFENKK K K n NI KLYV R RVF 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 306 I M DD A E QFM P N YL R FV R G LI DS N DLPLNVSRE I LQ DSTVTRNLRNA L TKR AL Q M LEKL A KDD a E K Y QT FWK Q FG LV LK E G 385
Cdd:pfam00183 161 I T DD F E DLI P E YL N FV K G VV DS D DLPLNVSRE T LQ QNKILKVIKKK L VRK AL D M FKEI A EEK - E D Y KK FWK E FG KN LK L G 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 386 PA ED TA N VETI AKLLRF A S TH td S SAQTV SL EE YVSRMKEGQ EK IYYIT AD S YAAAKS SP H LE L L R KKG I EVL L L S D R ID 465
Cdd:pfam00183 240 II ED SS N RNKL AKLLRF Y S SK -- S GDELT SL DD YVSRMKEGQ KH IYYIT GE S KEEVEN SP F LE R L K KKG Y EVL Y L T D P ID 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 466 E WMMNY L T EFDGK AFQS VAK ADESIDKLAD E v DESAK E AE K AL EP FVERV K TL LGD R V KE V RFTH RL T D T P AIVT T DADE 545
Cdd:pfam00183 318 E YAVQQ L K EFDGK KLVN VAK EGLELEEDEE E - KKKDE E LK K EF EP LTKWL K DV LGD K V EK V VVSN RL V D S P CVLV T SQYG 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 546 M S TQ M AKLFA A ag QA VPE --------- V K YIF E L NP D HP LV K ---- R AADTQ D EARFAEWVE LL LDQS LL AERGT LEDP N 612
Cdd:pfam00183 397 W S AN M ERIMK A -- QA LRK dssmssyms S K KTL E I NP R HP II K ellk R VEADK D DKTAKDLAL LL YETA LL RSGFS LEDP A 474
490
....*....|
gi 556480674 613 L F IK R VNAL L 622
Cdd:pfam00183 475 S F AS R IYRM L 484
PTZ00130
PTZ00130 heat shock protein 90; Provisional
2-610
2.80e-124
heat shock protein 90; Provisional
Pssm-ID: 185466 [Multi-domain]
Cd Length: 814
Bit Score: 386.70
E-value: 2.80e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 2 K G Q E TRGF Q S EV KQ L LHLMIH SLY SN KE I FLRELISNA S DA AD K L RF RA LS NPDLYEGDGE L RV R V S F NKE NRT L T I A D N 81
Cdd:PTZ00130 63 S G I E QHQY Q T EV TR L MDIIVN SLY TQ KE V FLRELISNA A DA LE K I RF LS LS DESVLGEEKK L EI R I S A NKE KNI L S I T D T 142
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 82 GIGM NRDEV I DH LGTIAKSGT KA FLE SM g S DQAK D SQ LIGQFGVGFYSAF I VADKV T V R T RAAG D SA eng VL WES KGEGE 161
Cdd:PTZ00130 143 GIGM TKEDL I NN LGTIAKSGT SN FLE AI - S KSGG D MS LIGQFGVGFYSAF L VADKV I V Y T KNNN D EQ --- YI WES TADAK 218
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 162 Y T VDDITKA --- D RGT E I T LHL R E GEDDFL ND WRVRSI ISKYS DH I AL P ----------------------------- V E 209
Cdd:PTZ00130 219 F T IYKDPRG stl K RGT R I S LHL K E DATNLM ND KKLVDL ISKYS QF I QY P iyllhenvyteevladiakemendpnyds V K 298
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 210 I E KQEEKDGE T ------ V VS W EKI N KAQAL W T R NKS E IK D DE Y NE F YKHIAHDFTD PL TWS H NRV EG KQ E YTS L L YIP AQ 283
Cdd:PTZ00130 299 V E ETDDPNKK T rtvekk V KK W KLM N EQKPI W L R PPK E LT D ED Y KK F FSVLSGFNDE PL YHI H FFA EG EI E FKC L I YIP SR 378
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 284 AP W dmw NR DH ---- KHGL KLYV Q RV FIM D DAEQ F M P N Y LR FV R G LI DS N DLPLNVSRE I LQ DSTVTRNLRNALTKRA L QM 359
Cdd:PTZ00130 379 AP S --- IN DH lftk QNSI KLYV R RV LVA D EFVE F L P R Y MS FV K G VV DS D DLPLNVSRE Q LQ QNKILKAVSKRIVRKI L DT 455
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 360 LEK L A K D ---------------- D A EK ------------- Y QTFW K QFGLV LK E G PA ED TA N VET I A KLL R F ast H T DSS 410
Cdd:PTZ00130 456 FRT L Y K E gkknketlraelaket D E EK kkeiqkkinepst Y KLIY K EYRKY LK T G CY ED DI N RNK I V KLL L F --- K T MLH 532
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 411 AQTV SL EE Y VSR MK EG Q EK IYY ITA DSY AAAKSS P H L ELLR KK G I E V LL L SDRI DE WMMNYLT E F DGK A F Q S VA K ADESI 490
Cdd:PTZ00130 533 PKSI SL DT Y IEN MK PD Q KF IYY ASG DSY EYLSKI P Q L QIFK KK N I D V VF L TESV DE SCVQRVQ E Y DGK K F K S IQ K GEITF 612
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 491 D k L ADEVDESAKEAE K ALEPFVERVKTL L GDRVKE V RFTH RL T D T P AI V TTDADEM S T QM A KL FAAAGQAVPEV K Y ---- 566
Cdd:PTZ00130 613 E - L TEDEKKKEEKVK K MYKALIDVISDT L RNQIFK V EISR RL V D A P CA V VSTEWGL S G QM E KL MKINVNNSDQI K A msgq 691
650 660 670 680
....*....|....*....|....*....|....*....|....*....
gi 556480674 567 - I F E L NPDHP ---- L V KR AADTQDEARFA E WVELLLDQSL LA ERGT LED 610
Cdd:PTZ00130 692 k I L E I NPDHP imid L L KR SVSNPKDSQLT E SIKIIYQSAK LA SGFD LED 740
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
14-204
9.11e-107
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 319.85
E-value: 9.11e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 14 K QLL H L M IHSLYSNKEIFLRELISNASDA A DKLR FRA L SN P D L YEG D G EL RV R V S FN KENRTLTI A D N GIGM NRD E V I DH 93
Cdd:cd16927 1 N QLL D L I IHSLYSNKEIFLRELISNASDA L DKLR YLS L TD P S L LDD D P EL EI R I S PD KENRTLTI S D T GIGM TKE E L I NN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 94 LGTIA K SGTKAFLE SMGSD q AKDS Q LIGQFGVGFYSAF I VADKVTV R T RA AGD S ae N G VL WES K G E G E YT VDDITKA - D R 172
Cdd:cd16927 81 LGTIA R SGTKAFLE ALQEG - AKDS D LIGQFGVGFYSAF M VADKVTV T T KS AGD D -- E G YR WES D G G G S YT IEEAEGE l G R 157
170 180 190
....*....|....*....|....*....|..
gi 556480674 173 GT E ITLHL R E GEDD FL NDW R VRSIIS KYSD H I 204
Cdd:cd16927 158 GT K ITLHL K E DAKE FL EEA R IKELVK KYSD F I 189
PRK14083
PRK14083 HSP90 family protein; Provisional
7-602
2.19e-46
HSP90 family protein; Provisional
Pssm-ID: 237603 [Multi-domain]
Cd Length: 601
Bit Score: 172.82
E-value: 2.19e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 7 RG FQ SEVKQLLH L MIHS LYS NKEIFL REL IS NA S DA adk LRF R ALSN P DL yegdg EL R V R VS - FNKENR TL TIA DNGIG M 85
Cdd:PRK14083 3 HR FQ VDLRGVID L LSRH LYS SPRVYV REL LQ NA V DA --- ITA R RALD P TA ----- PG R I R IE l TDAGGG TL IVE DNGIG L 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 86 NRD EV IDH L G TI AK S GTK afl ESMGSDQAK D sq LI GQFG V G FY S A F I VAD KVT V RT R A A G D S ae NG V L W ES K GE G E Y T V D 165
Cdd:PRK14083 75 TEE EV HEF L A TI GR S SKR --- DENLGFARN D -- FL GQFG I G LL S C F L VAD EIV V VS R S A K D G -- PA V E W RG K AD G T Y S V R 147
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 166 DITKADR -- GT EIT L HL R EGEDDF L NDWR V RSIIS KY SDHIAL P VEI E KQEEKDG ET VVS W eki NKAQALWTRNKSEI -- 241
Cdd:PRK14083 148 KLETERA ep GT TVY L RP R PDAEEW L ERET V EELAK KY GSLLPV P IRV E GEKGGVN ET PPP W --- TRDYPDPETRREAL la 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 242 -- KDDEYNEFYKH I ahdftd PL TWSHNRV EG kqeyts LL Y I - P AQAPW dmw NRDH KH gl KL Y VQ R VFIMDD AE QFM P NYL 318
Cdd:PRK14083 225 yg EELLGFTPLDV I ------ PL DVPSGGL EG ------ VA Y V l P YAVSP --- AARR KH -- RV Y LK R MLLSEE AE NLL P DWA 287
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 319 R FVR GLIDSND L PLNV SRE I L QDSTVTRNL R NA L TKRALQM L EK LA KD D A E KYQTFWKQFG L VL K EGPAE D TANVET I AK 398
Cdd:PRK14083 288 F FVR CVVNTDE L RPTA SRE A L YEDDALAAV R EE L GEAIRKW L IG LA TT D P E RLRRLLAVHH L GV K ALASH D DELLRL I LP 367
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 399 L L R F astht DSSAQTVS L E E YVS R MKE gqek I Y Y I - TA D SY ------ A A A KSSP -------- HL ELL RK kgievll L SDR 463
Cdd:PRK14083 368 W L P F ----- ETTDGRMT L A E IRR R HGV ---- I R Y T s SV D EF rqlapi A R A QGMG vinggyty DS ELL ER ------- L PRL 431
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 464 IDEW mmnyltefdgkafq S V AKA D es IDK L A D EVDESAK E A E K AL E PF VERVKTL L GDRVKE V RFT H RL - T D T PA IVTT D 542
Cdd:PRK14083 432 RPGL -------------- T V ERL D -- PAE L T D RLEPLTP E E E L AL R PF LAEAREV L APFGCD V VIR H FE p A D L PA LYLH D 495
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556480674 543 ADEMSTQMAK -------- L F A A ----- AGQAVPEVKYIF e LN PDH PLV K R A A DTQ D EARFAEW VE L L LD Q S LL 602
Cdd:PRK14083 496 RAAQHSRERE eaveeadd L W A D ilgsl DESQPAPRARLV - LN LRN PLV R R L A TLG D PKLLSRA VE A L YV Q A LL 567
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
27-181
1.12e-11
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 61.90
E-value: 1.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 27 NKEIF LR ELI SN AS D A A D K LRFR alsnpdlyeg D G ELR V RVSFNKENRTL T IA DNG I G MN r D E VIDHL gtiaksgtkaf L 106
Cdd:smart00387 1 GDPDR LR QVL SN LL D N A I K YTPE ---------- G G RIT V TLERDGDHVEI T VE DNG P G IP - P E DLEKI ----------- F 58
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 556480674 107 E SMGS d QA K D S QL IG QF G V G FYSAFIVADKV tvrtraagdsaengvlweskg E GE YT V DD it KADR GT EI T LH L R 181
Cdd:smart00387 59 E PFFR - TD K R S RK IG GT G L G LSIVKKLVELH --------------------- G GE IS V ES -- EPGG GT TF T IT L P 109
HATPase_c
pfam02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
27-184
2.52e-06
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain]
Cd Length: 109
Bit Score: 46.59
E-value: 2.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 27 NK E IF LR ELI SN AS D A A D K LRFR A lsnpdlyegd GE LR V RV S f NKENR TLT IA DNGIG MNRDE v IDHLGT iaksgtk A F L 106
Cdd:pfam02518 1 GD E LR LR QVL SN LL D N A L K HAAK A ---------- GE IT V TL S - EGGEL TLT VE DNGIG IPPED - LPRIFE ------- P F S 61
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556480674 107 ESMGSDQ akdsqli G QF G V G FYSAFIVADKV tvrtraagdsae N G VLWESKGE G eytvdditkad R GT EI TL H L REGE 184
Cdd:pfam02518 62 TADKRGG ------- G GT G L G LSIVRKLVELL ------------ G G TITVESEP G ----------- G GT TV TL T L PLAQ 109
HATPase_TopVIB-like
cd16933 Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ...
21-222
1.07e-04
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain]
Cd Length: 203
Bit Score: 43.88
E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 21 I H SLY snke IFL REL IS N AS DA A dklrfralsnpdly E GD G E L - RVR V SFNKENR --- TLTIA DNG I G MNRDEV idhlgt 96
Cdd:cd16933 17 I R SLY ---- TTV REL VE N SL DA T -------------- E EA G I L p DIK V EIEEIGK dhy KVIVE DNG P G IPEEQI ------ 72
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 97 iaksg T K A F LESMGSDQAKDS Q LI GQ F G V G ----- F YS AFIVADK V TVRTRAAGDSAENG V --- LWES K G E G --- E YTVD 165
Cdd:cd16933 73 ----- P K V F GKVLYGSKYHNK Q SR GQ Q G L G isaav L YS QMTTGKP V EIISSTKDSNYAYV V klm IDTD K N E P eil E KEEV 147
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 166 DITKADR GT EIT L H L RE geddfl N DWRV RS I I SK Y SDH --- IA LPV EI EKQEEKDGET V V 222
Cdd:cd16933 148 ENRYKWH GT RVE L E L EG ------ N WVAA RS Q I LE Y YKR tav IA PYA EI IFIVPDGETE V F 201
HATPase_c_3
pfam13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
29-168
1.40e-03
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433332 [Multi-domain]
Cd Length: 135
Bit Score: 39.24
E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 29 E IF L R ELI S N AS DA adklrf R A LS npdlyegdge LRVR V SF N KENR T - LT I A D N G I GM NRD E V I DH L G t I A K S GTK A fle 107
Cdd:pfam13589 2 E GA L A ELI D N SI DA ------ D A TN ---------- IKIE V NK N RGGG T e IV I E D D G H GM SPE E L I NA L R - L A T S AKE A --- 61
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 556480674 108 smgsdq AKD S QLI G QF G V G FYS A - FIVAD K V TV RTRAA G D S AENGVLWE - SKG E GEYTVDDI T 168
Cdd:pfam13589 62 ------ KRG S TDL G RY G I G LKL A s LSLGA K L TV TSKKE G K S STLTLDRD k ISN E NDWLLPLL T 118
HATPase_MORC-like
cd16931 Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
34-129
5.12e-03
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.
Pssm-ID: 340408 [Multi-domain]
Cd Length: 118
Bit Score: 37.39
E-value: 5.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480674 34 EL IS NA S DA - A DK L RFRALSNPD L yeg D G EL rvrvsfnkenr T L TIA D N G I GM NRD E VIDHL gtiaksgtkafle S M G SD 112
Cdd:cd16931 18 EL VD NA R DA d A TR L DIFIDDINL L --- R G GF ----------- M L SFL D D G N GM TPE E AHHMI ------------- S F G FS 70
90
....*....|....*....
gi 556480674 113 QAK -- D SQL IG QF G V GF Y S 129
Cdd:cd16931 71 DKR sd D HDH IG RY G N GF K S 89
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
