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Conserved domains on  [gi|556480684|ref|WP_023332264|]
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MULTISPECIES: HNH endonuclease [Enterobacter]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HNH_5 super family cl23656
HNH endonuclease; This domain is related to other HNH domain families such as pfam01844. ...
 37-80 3.15e-05

HNH endonuclease; This domain is related to other HNH domain families such as pfam01844. Suggesting that these proteins have a nucleic acid cleaving function.


The actual alignment was detected with superfamily member pfam14279:

Pssm-ID: 464124 [Multi-domain]  Cd Length: 56  Bit Score: 40.40  E-value: 3.15e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 556480684   37 CYICE-TKSPLDINVEHFIPhmGDINKKFDWSNLYLVCSRCNNIK 80
Cdd:pfam14279   1 CIYCGkEFPEKNLTIEHIIP--ESLGGKNKISNLQTLCKKCNSKK 43
HNHc super family cl00083
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 24-143 3.14e-03

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


The actual alignment was detected with superfamily member TIGR02646:

Pssm-ID: 469607 [Multi-domain]  Cd Length: 144  Bit Score: 36.72  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480684   24 DVYIALEQSFYKKCYICE-TKSPLDINVEHFIPHMGDINKKFDWSNLYLVC----SRCNNIKLAKYKNlLDCCNDSVWDK 98
Cdd:TIGR02646  14 EVHNQLLQLQGGLCAYCErEIELLGSHIEHFRPKGAYPPLTLDWSNLFGSChresKQGNPLHCGRFKD-NSCGSNNFDEL 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 556480684   99 VKLLpgfSPGAKNFFI--------------EAMVHDAAtiETADLLNevYNNDKTINKR 143
Cdd:TIGR02646  93 IDPL---ADDCEQLFTylltgkiepresraPTDVEKAK--ETIEVLN--LNAKRLTRRR 144
 
Name Accession Description Interval E-value
HNH_5 pfam14279
HNH endonuclease; This domain is related to other HNH domain families such as pfam01844. ...
 37-80 3.15e-05

HNH endonuclease; This domain is related to other HNH domain families such as pfam01844. Suggesting that these proteins have a nucleic acid cleaving function.


Pssm-ID: 464124 [Multi-domain]  Cd Length: 56  Bit Score: 40.40  E-value: 3.15e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 556480684   37 CYICE-TKSPLDINVEHFIPhmGDINKKFDWSNLYLVCSRCNNIK 80
Cdd:pfam14279   1 CIYCGkEFPEKNLTIEHIIP--ESLGGKNKISNLQTLCKKCNSKK 43
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
36-80 5.02e-04

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 37.27  E-value: 5.02e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 556480684  36 KCYICETK-SPLDINVEHFIPH-MGDINkkfDWSNLYLVCSRCNNIK 80
Cdd:COG1403   21 RCQYCGRPfSGDALEVDHIIPRsRGGTD---TWENLVLLCRRCNRRK 64
TIGR02646 TIGR02646
TIGR02646 family protein; Members of this uncharacterized protein family are found exclusively ...
 24-143 3.14e-03

TIGR02646 family protein; Members of this uncharacterized protein family are found exclusively in bacteria. Neighboring genes in various genomes are also uncharacterized or may annotated as similar to restriction system proteins. [Hypothetical proteins, Conserved]


Pssm-ID: 131694 [Multi-domain]  Cd Length: 144  Bit Score: 36.72  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480684   24 DVYIALEQSFYKKCYICE-TKSPLDINVEHFIPHMGDINKKFDWSNLYLVC----SRCNNIKLAKYKNlLDCCNDSVWDK 98
Cdd:TIGR02646  14 EVHNQLLQLQGGLCAYCErEIELLGSHIEHFRPKGAYPPLTLDWSNLFGSChresKQGNPLHCGRFKD-NSCGSNNFDEL 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 556480684   99 VKLLpgfSPGAKNFFI--------------EAMVHDAAtiETADLLNevYNNDKTINKR 143
Cdd:TIGR02646  93 IDPL---ADDCEQLFTylltgkiepresraPTDVEKAK--ETIEVLN--LNAKRLTRRR 144
 
Name Accession Description Interval E-value
HNH_5 pfam14279
HNH endonuclease; This domain is related to other HNH domain families such as pfam01844. ...
 37-80 3.15e-05

HNH endonuclease; This domain is related to other HNH domain families such as pfam01844. Suggesting that these proteins have a nucleic acid cleaving function.


Pssm-ID: 464124 [Multi-domain]  Cd Length: 56  Bit Score: 40.40  E-value: 3.15e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 556480684   37 CYICE-TKSPLDINVEHFIPhmGDINKKFDWSNLYLVCSRCNNIK 80
Cdd:pfam14279   1 CIYCGkEFPEKNLTIEHIIP--ESLGGKNKISNLQTLCKKCNSKK 43
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
36-80 5.02e-04

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 37.27  E-value: 5.02e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 556480684  36 KCYICETK-SPLDINVEHFIPH-MGDINkkfDWSNLYLVCSRCNNIK 80
Cdd:COG1403   21 RCQYCGRPfSGDALEVDHIIPRsRGGTD---TWENLVLLCRRCNRRK 64
TIGR02646 TIGR02646
TIGR02646 family protein; Members of this uncharacterized protein family are found exclusively ...
 24-143 3.14e-03

TIGR02646 family protein; Members of this uncharacterized protein family are found exclusively in bacteria. Neighboring genes in various genomes are also uncharacterized or may annotated as similar to restriction system proteins. [Hypothetical proteins, Conserved]


Pssm-ID: 131694 [Multi-domain]  Cd Length: 144  Bit Score: 36.72  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556480684   24 DVYIALEQSFYKKCYICE-TKSPLDINVEHFIPHMGDINKKFDWSNLYLVC----SRCNNIKLAKYKNlLDCCNDSVWDK 98
Cdd:TIGR02646  14 EVHNQLLQLQGGLCAYCErEIELLGSHIEHFRPKGAYPPLTLDWSNLFGSChresKQGNPLHCGRFKD-NSCGSNNFDEL 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 556480684   99 VKLLpgfSPGAKNFFI--------------EAMVHDAAtiETADLLNevYNNDKTINKR 143
Cdd:TIGR02646  93 IDPL---ADDCEQLFTylltgkiepresraPTDVEKAK--ETIEVLN--LNAKRLTRRR 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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