NCBI Conserved Domain Search

Conserved domains on [gi|556490405|ref|WP_023338131|]

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MULTISPECIES: bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD [Enterobacter]

Protein Classification

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase( domain architecture ID 11484949)

bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/ 5,10-methenyltetrahydrofolate cyclohydrolase reversibly catalyzes oxidation of 5,10-methylene-THF to 5,10-methenyl-THF and hydrolysis of 5,10-methenyl-THF to 10-formyl-THF

CATH: 3.40.50.720|3.40.50.10860

EC: 1.5.1.5|3.5.4.9

Gene Ontology: GO:0004488|GO:0003824|GO:0016787|GO:0009086|GO:0006164|GO:0006730

PubMed: 1748668|10386884

SCOP: 4000102

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

PRK10792

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-285

0e+00

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 236760 [Multi-domain] Cd Length: 285 Bit Score: 612.69 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   1 MAAKIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK10792   1 MTAKIIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSDPASQVYVASKRKACEEVGFVSRSYDLPETTSEAELL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  81 ELIDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK10792  81 ALIDELNADPTIDGILVQLPLPAHIDNVKVLERIHPDKDVDGFHPYNVGRLAQRIPLLRPCTPRGIMTLLERYGIDTYGL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKV 240
Cdd:PRK10792 161 NAVVVGASNIVGRPMSLELLLAGCTVTVCHRFTKNLRHHVRNADLLVVAVGKPGFIPGEWIKPGAIVIDVGINRLEDGKL 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 556490405 241 VGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEEYHDV 285
Cdd:PRK10792 241 VGDVEFETAAERASWITPVPGGVGPMTVATLLENTLQACEEYHDP 285

Name

Accession

Description

Interval

E-value

PRK10792

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-285

0e+00

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 236760 [Multi-domain] Cd Length: 285 Bit Score: 612.69 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   1 MAAKIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK10792   1 MTAKIIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSDPASQVYVASKRKACEEVGFVSRSYDLPETTSEAELL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  81 ELIDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK10792  81 ALIDELNADPTIDGILVQLPLPAHIDNVKVLERIHPDKDVDGFHPYNVGRLAQRIPLLRPCTPRGIMTLLERYGIDTYGL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKV 240
Cdd:PRK10792 161 NAVVVGASNIVGRPMSLELLLAGCTVTVCHRFTKNLRHHVRNADLLVVAVGKPGFIPGEWIKPGAIVIDVGINRLEDGKL 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 556490405 241 VGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEEYHDV 285
Cdd:PRK10792 241 VGDVEFETAAERASWITPVPGGVGPMTVATLLENTLQACEEYHDP 285

FolD

COG0190

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...

1-286

0e+00

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];

Pssm-ID: 439960 [Multi-domain] Cd Length: 285 Bit Score: 513.79 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   1 MAAKIIDGKTIAQQVRSEVAEKVKARKVAGkRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:COG0190    1 MMAQILDGKAVAAEIREELKERVAALKAKG-ITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  81 ELIDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:COG0190   80 ALIDELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKV 240
Cdd:COG0190  160 HAVVVGRSNIVGKPLALLLLRRNATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGINRVEDGKL 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 556490405 241 VGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEEYHDVE 286
Cdd:COG0190  240 VGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQAGLR 285

THF_DHG_CYH_C

pfam02882

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;

124-283

8.52e-95

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;

Pssm-ID: 427036 Cd Length: 160 Bit Score: 276.27 E-value: 8.52e-95

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENA 203
Cdd:pfam02882   1 HPYNLGRLVLGKPCFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLNANATVTVCHSKTKDLAEITREA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  204 DLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEEYH 283
Cdd:pfam02882  81 DIVVVAVGKPELIKADWIKPGAVVIDVGINRVGNGKLVGDVDFENVKEKASAITPVPGGVGPMTVAMLLQNTVEAAKRQL 160

NAD_bind_m-THF_DH_Cyclohyd

cd01080

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...

116-280

9.59e-90

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding domain of the Methylene-Tetrahydrofolate Dehydrogenase/cyclohydrolase (m-THF DH/cyclohydrolase) bifunctional enzyme. Tetrahydrofolate is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofucntional DH, as well as bifunctional m-THF m-THF DHm-THF DHDH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains the bifunctional DH/cyclohydrolase. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains.

Pssm-ID: 133448 Cd Length: 168 Bit Score: 264.03 E-value: 9.59e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 116 PDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKN 195
Cdd:cd01080    1 PEKDVDGLHPVNLGRLALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLLNRNATVTVCHSKTKN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 196 LRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLE---SGKVVGDVVYEDAAARASYITPVPGGVGPMTVATLI 272
Cdd:cd01080   81 LKEHTKQADIVIVAVGKPGLVKGDMVKPGAVVIDVGINRVPdksGGKLVGDVDFESAKEKASAITPVPGGVGPMTVAMLM 160


                 ....*...
gi 556490405 273 QNTLQACE 280
Cdd:cd01080  161 KNTVEAAK 168

Name

Accession

Description

Interval

E-value

PRK10792

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-285

0e+00

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 236760 [Multi-domain] Cd Length: 285 Bit Score: 612.69 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   1 MAAKIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK10792   1 MTAKIIDGKTIAQQVRSEVAQKVQARVAAGLRAPGLAVVLVGSDPASQVYVASKRKACEEVGFVSRSYDLPETTSEAELL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  81 ELIDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK10792  81 ALIDELNADPTIDGILVQLPLPAHIDNVKVLERIHPDKDVDGFHPYNVGRLAQRIPLLRPCTPRGIMTLLERYGIDTYGL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKV 240
Cdd:PRK10792 161 NAVVVGASNIVGRPMSLELLLAGCTVTVCHRFTKNLRHHVRNADLLVVAVGKPGFIPGEWIKPGAIVIDVGINRLEDGKL 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 556490405 241 VGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEEYHDV 285
Cdd:PRK10792 241 VGDVEFETAAERASWITPVPGGVGPMTVATLLENTLQACEEYHDP 285

FolD

COG0190

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase ...

1-286

0e+00

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism];

Pssm-ID: 439960 [Multi-domain] Cd Length: 285 Bit Score: 513.79 E-value: 0e+00

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   1 MAAKIIDGKTIAQQVRSEVAEKVKARKVAGkRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:COG0190    1 MMAQILDGKAVAAEIREELKERVAALKAKG-ITPGLAVVLVGDDPASQVYVRNKHKACEEVGIESELIRLPADTTQEELL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  81 ELIDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:COG0190   80 ALIDELNADPSVHGILVQLPLPKHIDEEAVLEAIDPEKDVDGFHPVNLGRLVLGEPGFVPCTPAGIMELLERYGIDLAGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKV 240
Cdd:COG0190  160 HAVVVGRSNIVGKPLALLLLRRNATVTVCHSRTKDLAEHTRQADILVAAVGKPGLITADMVKPGAVVIDVGINRVEDGKL 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 556490405 241 VGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEEYHDVE 286
Cdd:COG0190  240 VGDVDFESVAEKASAITPVPGGVGPMTIAMLLENTLKAAERQAGLR 285

PRK14190

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

1-285

4.24e-134

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184560 [Multi-domain] Cd Length: 284 Bit Score: 380.90 E-value: 4.24e-134

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   1 MAAKIIDGKTIAQQVRSEVAEKVKARKVAGKrAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14190   1 MMAVIIDGKEVAKEKREQLKEEVVKLKEQGI-VPGLAVILVGDDPASHSYVRGKKKAAEKVGIYSELYEFPADITEEELL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  81 ELIDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK14190  80 ALIDRLNADPRINGILVQLPLPKHIDEKAVIERISPEKDVDGFHPINVGRMMLGQDTFLPCTPHGILELLKEYNIDISGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKV 240
Cdd:PRK14190 160 HVVVVGRSNIVGKPVGQLLLNENATVTYCHSKTKNLAELTKQADILIVAVGKPKLITADMVKEGAVVIDVGVNRLENGKL 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 556490405 241 VGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEEYHDV 285
Cdd:PRK14190 240 CGDVDFDNVKEKASYITPVPGGVGPMTITMLMHNTVELAKRAGGR 284

PRK14189

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;

1-280

3.84e-129

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;

Pssm-ID: 184559 [Multi-domain] Cd Length: 285 Bit Score: 368.25 E-value: 3.84e-129

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   1 MAAKIIDGKTIAQQVRSEVAEKVKARKVAGKRaPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14189   1 MTAQLIDGNALSKQLRAEAAQRAAALTARGHQ-PGLAVILVGDNPASQVYVRNKVKACEDNGFHSLKDRYPADLSEAELL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  81 ELIDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK14189  80 ARIDELNRDPKIHGILVQLPLPKHIDSHKVIEAIAPEKDVDGFHVANAGALMTGQPLFRPCTPYGVMKMLESIGIPLRGA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKV 240
Cdd:PRK14189 160 HAVVIGRSNIVGKPMAMLLLQAGATVTICHSKTRDLAAHTRQADIVVAAVGKRNVLTADMVKPGATVIDVGMNRDDAGKL 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 556490405 241 VGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACE 280
Cdd:PRK14189 240 CGDVDFAGVKEVAGYITPVPGGVGPMTITMLLVNTIEAAE 279

PRK14191

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

4-280

3.32e-128

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172679 [Multi-domain] Cd Length: 285 Bit Score: 366.01 E-value: 3.32e-128

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   4 KIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELI 83
Cdd:PRK14191   2 VLLDGKALSYKIEKDLKNKIQILTAQTGKRPKLAVILVGKDPASQTYVNMKIKACERVGMDSDLHTLQENTTEAELLSLI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  84 DTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14191  82 KDLNTDQNIDGILVQLPLPRHIDTKMVLEAIDPNKDVDGFHPLNIGKLCSQLDGFVPATPMGVMRLLKHYHIEIKGKDVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 164 VIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVGD 243
Cdd:PRK14191 162 IIGASNIVGKPLAMLMLNAGASVSVCHILTKDLSFYTQNADIVCVGVGKPDLIKASMVKKGAVVVDIGINRLNDGRLVGD 241

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 556490405 244 VVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACE 280
Cdd:PRK14191 242 VDFENVAPKASFITPVPGGVGPMTIVSLLENTLIAAE 278

PRK14188

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

2-279

3.65e-127

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184558 [Multi-domain] Cd Length: 296 Bit Score: 363.51 E-value: 3.65e-127

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   2 AAKIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLE 81
Cdd:PRK14188   1 MATIIDGKAFAADVRATVAAEVARLKAAHGVTPGLAVVLVGEDPASQVYVRSKGKQTKEAGMASFEHKLPADTSQAELLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  82 LIDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLN 161
Cdd:PRK14188  81 LIARLNADPAIHGILVQLPLPKHLDSEAVIQAIDPEKDVDGLHVVNAGRLATGETALVPCTPLGCMMLLRRVHGDLSGLN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 162 AVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLES---- 237
Cdd:PRK14188 161 AVVIGRSNLVGKPMAQLLLAANATVTIAHSRTRDLPAVCRRADILVAAVGRPEMVKGDWIKPGATVIDVGINRIPApekg 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 556490405 238 ---GKVVGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQAC 279
Cdd:PRK14188 241 egkTRLVGDVAFAEAAEVAGAITPVPGGVGPMTIACLLANTLTAA 285

PRK14186

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

3-278

8.41e-122

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 237636 [Multi-domain] Cd Length: 297 Bit Score: 350.13 E-value: 8.41e-122

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   3 AKIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLEL 82
Cdd:PRK14186   2 ALILDGKALAAEIEQRLQAQIESNLPKAGRPPGLAVLRVGDDPASAVYVRNKEKACARVGIASFGKHLPADTSQAEVEAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  83 IDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNA 162
Cdd:PRK14186  82 IAQLNQDERVDGILLQLPLPKHLDEVPLLHAIDPDKDADGLHPLNLGRLVKGEPGLRSCTPAGVMRLLRSQQIDIAGKKA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 163 VVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLES----G 238
Cdd:PRK14186 162 VVVGRSILVGKPLALMLLAANATVTIAHSRTQDLASITREADILVAAAGRPNLIGAEMVKPGAVVVDVGIHRLPSsdgkT 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 556490405 239 KVVGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14186 242 RLCGDVDFEEVEPVAAAITPVPGGVGPMTVTMLLVNTVLS 281

PRK14184

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-278

3.42e-118

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 237635 [Multi-domain] Cd Length: 286 Bit Score: 340.60 E-value: 3.42e-118

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   5 IIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELID 84
Cdd:PRK14184   3 LLDGKATAATIREELKTEVAALTARHGRAPGLAVILVGEDPASQVYVRNKERACEDAGIVSEAFRLPADTTQEELEDLIA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  85 TLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVV 164
Cdd:PRK14184  83 ELNARPDIDGILLQLPLPKGLDSQRCLELIDPAKDVDGFHPENMGRLALGLPGFRPCTPAGVMTLLERYGLSPAGKKAVV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 165 IGASNIVGRPMSMELLLAG----CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGkV 240
Cdd:PRK14184 163 VGRSNIVGKPLALMLGAPGkfanATVTVCHSRTPDLAEECREADFLFVAIGRPRFVTADMVKPGAVVVDVGINRTDDG-L 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 556490405 241 VGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14184 242 VGDCDFEGLSDVASAITPVPGGVGPMTIAQLLVNTVQS 279

PRK14183

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

4-278

1.67e-113

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184555 [Multi-domain] Cd Length: 281 Bit Score: 328.71 E-value: 1.67e-113

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   4 KIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELI 83
Cdd:PRK14183   2 QILDGKALSDKIKENVKKEVDELKLVKNIVPGLAVILVGDDPASHTYVKMKAKACDRVGIYSITHEMPSTISQKEILETI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  84 DTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14183  82 AMMNNNPNIDGILVQLPLPKHIDTTKILEAIDPKKDVDGFHPYNVGRLVTGLDGFVPCTPLGVMELLEEYEIDVKGKDVC 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 164 VIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVGD 243
Cdd:PRK14183 162 VVGASNIVGKPMAALLLNANATVDICHIFTKDLKAHTKKADIVIVGVGKPNLITEDMVKEGAIVIDIGINRTEDGRLVGD 241

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 556490405 244 VVYEDAAARASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14183 242 VDFENVAKKCSYITPVPGGVGPMTIAMLLSNTLKA 276

PRK14179

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;

3-279

5.76e-113

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase;

Pssm-ID: 237634 [Multi-domain] Cd Length: 284 Bit Score: 327.09 E-value: 5.76e-113

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   3 AKIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLEL 82
Cdd:PRK14179   2 TEIIDGKALAQKMQAELAEKVAKLKEEKGIVPGLVVILVGDNPASQVYVRNKERSALAAGFKSEVVRLPETISQEELLDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  83 IDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNA 162
Cdd:PRK14179  82 IERYNQDPTWHGILVQLPLPKHINEEKILLAIDPKKDVDGFHPMNTGHLWSGRPVMIPCTPAGIMEMFREYNVELEGKHA 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 163 VVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVG 242
Cdd:PRK14179 162 VVIGRSNIVGKPMAQLLLDKNATVTLTHSRTRNLAEVARKADILVVAIGRGHFVTKEFVKEGAVVIDVGMNRDENGKLIG 241

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 556490405 243 DVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQAC 279
Cdd:PRK14179 242 DVDFDEVAEVASYITPVPGGVGPMTITMLMEQTYQAA 278

PRK14166

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-280

1.88e-107

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172654 [Multi-domain] Cd Length: 282 Bit Score: 313.12 E-value: 1.88e-107

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   5 IIDGKTIAQQVRSEVAEKVKARKVAGKRaPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELID 84
Cdd:PRK14166   3 LLDGKALSAKIKEELKEKNQFLKSKGIE-SCLAVILVGDNPASQTYVKSKAKACEECGIKSLVYHLNENTTQNELLALIN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  85 TLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRL-CQRAPRLRPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14166  82 TLNHDDSVHGILVQLPLPDHICKDLILESIISSKDVDGFHPINVGYLnLGLESGFLPCTPLGVMKLLKAYEIDLEGKDAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 164 VIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVGD 243
Cdd:PRK14166 162 IIGASNIVGRPMATMLLNAGATVSVCHIKTKDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVDVGINRLESGKIVGD 241

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 556490405 244 VVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACE 280
Cdd:PRK14166 242 VDFEEVSKKSSYITPVPGGVGPMTIAMLLENTVKSAK 278

PRK14176

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

4-281

8.53e-107

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184553 [Multi-domain] Cd Length: 287 Bit Score: 311.74 E-value: 8.53e-107

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   4 KIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELI 83
Cdd:PRK14176   9 RIIDGKALAKKIEAEVRSGVERLKSNRGITPGLATILVGDDPASKMYVRLKHKACERVGIRAEDQFLPADTTQEELLELI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  84 DTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14176  89 DSLNKRKDVHGILLQLPLPKHLDPQEAMEAIDPAKDADGFHPYNMGKLMIGDEGLVPCTPHGVIRALEEYGVDIEGKNAV 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 164 VIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRlESGKVVGD 243
Cdd:PRK14176 169 IVGHSNVVGKPMAAMLLNRNATVSVCHVFTDDLKKYTLDADILVVATGVKHLIKADMVKEGAVIFDVGITK-EEDKVYGD 247

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 556490405 244 VVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEE 281
Cdd:PRK14176 248 VDFENVIKKASLITPVPGGVGPLTIAMLMKHVLMCAEK 285

PRK14193

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

1-280

1.11e-102

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 237637 [Multi-domain] Cd Length: 284 Bit Score: 301.16 E-value: 1.11e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   1 MAAKIIDGKTIAQQVRSEVAEKVKARKVAGkRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14193   1 MTAIILDGKATADEIKADLAERVAALKEKG-ITPGLGTVLVGDDPGSQAYVRGKHRDCAEVGITSIRRDLPADATQEELN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  81 ELIDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK14193  80 AVIDELNADPACTGYIVQLPLPKHLDENAVLERIDPAKDADGLHPTNLGRLVLNEPAPLPCTPRGIVHLLRRYDVELAGA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 161 NAVVIGASNIVGRPMSMELLLAGCTTTVT--HRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESG 238
Cdd:PRK14193 160 HVVVIGRGVTVGRPIGLLLTRRSENATVTlcHTGTRDLAAHTRRADIIVAAAGVAHLVTADMVKPGAAVLDVGVSRAGDG 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 556490405 239 KVVGDvVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACE 280
Cdd:PRK14193 240 KLVGD-VHPDVWEVAGAVSPNPGGVGPMTRAFLLTNVVERAE 280

PRK14174

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-285

4.13e-101

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172662 [Multi-domain] Cd Length: 295 Bit Score: 297.50 E-value: 4.13e-101

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   5 IIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELID 84
Cdd:PRK14174   3 IIDGKKVSLDLKNELKTRVEAYRAKTGKVPGLTVIIVGEDPASQVYVRNKAKSCKEIGMNSTVIELPADTTEEHLLKKIE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  85 TLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRL-------CqraprLRPCTPRGIVTLLERYNIDT 157
Cdd:PRK14174  83 DLNNDPDVHGILVQQPLPKQIDEFAVTLAIDPAKDVDGFHPENLGRLvmghldkC-----FVSCTPYGILELLGRYNIET 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 158 YGLNAVVIGASNIVGRPMS----MELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGIN 233
Cdd:PRK14174 158 KGKHCVVVGRSNIVGKPMAnlmlQKLKESNCTVTICHSATKDIPSYTRQADILIAAIGKARFITADMVKPGAVVIDVGIN 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 556490405 234 RLE-----SG-KVVGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEEYHDV 285
Cdd:PRK14174 238 RIEdpstkSGyRLVGDVDYEGVSAKASAITPVPGGVGPMTIAMLLKNTLQSFERVNNL 295

PRK14182

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-277

5.82e-99

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172670 [Multi-domain] Cd Length: 282 Bit Score: 291.54 E-value: 5.82e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   5 IIDGKTIAQQVRSEVAEKVKARKVAGKrAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELID 84
Cdd:PRK14182   3 LIDGKQIAAKVKGEVATEVRALAARGV-QTGLTVVRVGDDPASAIYVRGKRKDCEEVGITSVEHHLPATTTQAELLALIA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  85 TLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRL-RPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14182  82 RLNADPAVHGILVQLPLPKHVDERAVLDAISPAKDADGFHPFNVGALSIGIAGVpRPCTPAGVMRMLDEARVDPKGKRAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 164 VIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVGD 243
Cdd:PRK14182 162 VVGRSNIVGKPMAMMLLERHATVTIAHSRTADLAGEVGRADILVAAIGKAELVKGAWVKEGAVVIDVGMNRLADGKLVGD 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 556490405 244 VVYEDAAARASYITPVPGGVGPMTVATLIQNTLQ 277
Cdd:PRK14182 242 VEFAAAAARASAITPVPGGVGPMTRAMLLVNTVE 275

PRK14194

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-283

3.47e-98

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172682 [Multi-domain] Cd Length: 301 Bit Score: 290.21 E-value: 3.47e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   1 MAAKIIDGKTIAQQVRSEVAEKVKARKVAGKRaPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14194   2 MSAKLIDGKAAAARVLAQVREDVRTLKAAGIE-PALAVILVGNDPASQVYVRNKILRAEEAGIRSLEHRLPADTSQARLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  81 ELIDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK14194  81 ALIAELNADPSVNGILLQLPLPAHIDEARVLQAINPLKDVDGFHSENVGGLSQGRDVLTPCTPSGCLRLLEDTCGDLTGK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESG-- 238
Cdd:PRK14194 161 HAVVIGRSNIVGKPMAALLLQAHCSVTVVHSRSTDAKALCRQADIVVAAVGRPRLIDADWLKPGAVVIDVGINRIDDDgr 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 556490405 239 -KVVGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEEYH 283
Cdd:PRK14194 241 sRLVGDVDFDSALPVVSAITPVPGGVGPMTIAFLMKNTVTAARLQA 286

PLN02616

tetrahydrofolate dehydrogenase/cyclohydrolase, putative

2-286

4.14e-98

tetrahydrofolate dehydrogenase/cyclohydrolase, putative

Pssm-ID: 215332 [Multi-domain] Cd Length: 364 Bit Score: 292.29 E-value: 4.14e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   2 AAKIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLE 81
Cdd:PLN02616  72 GAKVIDGKAVAKKIRDEITIEVSRMKESIGVVPGLAVILVGDRKDSATYVRNKKKACDSVGINSFEVRLPEDSTEQEVLK 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  82 LIDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRA--PRLRPCTPRGIVTLLERYNIDTYG 159
Cdd:PLN02616 152 FISGFNNDPSVHGILVQLPLPSHMDEQNILNAVSIEKDVDGFHPLNIGRLAMRGrePLFVPCTPKGCIELLHRYNVEIKG 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 160 LNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESG- 238
Cdd:PLN02616 232 KRAVVIGRSNIVGMPAALLLQREDATVSIVHSRTKNPEEITREADIIISAVGQPNMVRGSWIKPGAVVIDVGINPVEDAs 311

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 556490405 239 -----KVVGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEEYHDVE 286
Cdd:PLN02616 312 sprgyRLVGDVCYEEACKVASAVTPVPGGVGPMTIAMLLSNTLTSAKRIHNFQ 364

PRK14167

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

3-286

2.25e-97

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184549 [Multi-domain] Cd Length: 297 Bit Score: 288.21 E-value: 2.25e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   3 AKIIDGKTIAQQVRSEVAEKVKARKVAGKRaPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLEL 82
Cdd:PRK14167   2 TEIIDGNAVAAQIRDDLTDAIETLEDAGVT-PGLATVLMSDDPASETYVSMKQRDCEEVGIEAIDVEIDPDAPAEELYDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  83 IDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNA 162
Cdd:PRK14167  81 IDELNADEDVHGILVQMPVPDHVDDREVLRRIDPAKDVDGFHPENVGRLVAGDARFKPCTPHGIQKLLAAAGVDTEGADV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 163 VVIGASNIVGRPMSMELLLAG----CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESG 238
Cdd:PRK14167 161 VVVGRSDIVGKPMANLLIQKAdggnATVTVCHSRTDDLAAKTRRADIVVAAAGVPELIDGSMLSEGATVIDVGINRVDAD 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 556490405 239 -----KVVGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEEYHDVE 286
Cdd:PRK14167 241 tekgyELVGDVEFESAKEKASAITPVPGGVGPMTRAMLLYNTVKAASLQEGVD 293

PRK14180

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

5-281

4.96e-97

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172668 [Multi-domain] Cd Length: 282 Bit Score: 286.93 E-value: 4.96e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   5 IIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELID 84
Cdd:PRK14180   3 LIDGKSLSKDLKERLATQVQEYKHHTAITPKLVAIIVGNDPASKTYVASKEKACAQVGIDSQVITLPEHTTESELLELID 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  85 TLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPR-LRPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14180  83 QLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDVDGFHPTNVGRLQLRDKKcLESCTPKGIMTMLREYGIKTEGAYAV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 164 VIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLEsGKVVGD 243
Cdd:PRK14180 163 VVGASNVVGKPVSQLLLNAKATVTTCHRFTTDLKSHTTKADILIVAVGKPNFITADMVKEGAVVIDVGINHVD-GKIVGD 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 556490405 244 VVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEE 281
Cdd:PRK14180 242 VDFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQE 279

PLN02516

methylenetetrahydrofolate dehydrogenase (NADP+)

3-276

1.24e-96

methylenetetrahydrofolate dehydrogenase (NADP+)

Pssm-ID: 178131 [Multi-domain] Cd Length: 299 Bit Score: 286.40 E-value: 1.24e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   3 AKIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLEL 82
Cdd:PLN02516   9 AQIIDGKAIAKAIRSEIAEEVAQLSEKHGKVPGLAVVIVGSRKDSQTYVNMKRKACAEVGIKSFDVDLPENISEAELISK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  83 IDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQ--RAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PLN02516  89 VHELNANPDVHGILVQLPLPKHINEEKILNEISLEKDVDGFHPLNIGKLAMkgREPLFLPCTPKGCLELLSRSGIPIKGK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRL----- 235
Cdd:PLN02516 169 KAVVVGRSNIVGLPVSLLLLKADATVTVVHSRTPDPESIVREADIVIAAAGQAMMIKGDWIKPGAAVIDVGTNAVsdpsk 248

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 556490405 236 ESG-KVVGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTL 276
Cdd:PLN02516 249 KSGyRLVGDVDFAEVSKVAGWITPVPGGVGPMTVAMLLKNTV 290

PRK14175

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-278

5.25e-96

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184552 [Multi-domain] Cd Length: 286 Bit Score: 284.50 E-value: 5.25e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   1 MAAKIIDGKTIAQQVRSEVAEKVKARKVAGkRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14175   1 MVAKILDGKQIAKDYRQGLQDQVEALKEKG-FTPKLSVILVGNDGASQSYVRSKKKAAEKIGMISEIVHLEETATEEEVL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  81 ELIDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK14175  80 NELNRLNNDDSVSGILVQVPLPKQVSEQKILEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADIDLEGK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKV 240
Cdd:PRK14175 160 NAVVIGRSHIVGQPVSKLLLQKNASVTILHSRSKDMASYLKDADVIVSAVGKPGLVTKDVVKEGAVIIDVGNTPDENGKL 239

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 556490405 241 VGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14175 240 KGDVDYDAVKEIAGAITPVPGGVGPLTITMVLNNTLLA 277

THF_DHG_CYH_C

pfam02882

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;

124-283

8.52e-95

Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain;

Pssm-ID: 427036 Cd Length: 160 Bit Score: 276.27 E-value: 8.52e-95

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  124 HPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENA 203
Cdd:pfam02882   1 HPYNLGRLVLGKPCFVPCTPRGIMELLKRYGIDLAGKNVVVVGRSNIVGKPLALLLLNANATVTVCHSKTKDLAEITREA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  204 DLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEEYH 283
Cdd:pfam02882  81 DIVVVAVGKPELIKADWIKPGAVVIDVGINRVGNGKLVGDVDFENVKEKASAITPVPGGVGPMTVAMLLQNTVEAAKRQL 160

PRK14173

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

1-280

1.47e-94

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 184551 [Multi-domain] Cd Length: 287 Bit Score: 280.56 E-value: 1.47e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   1 MAAKIIDGKTIAQQVRSEVaekvKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14173   1 MAARELSGPPAAEAVYAEL----RARLAKLPFVPHLRVVRLGEDPASVSYVRLKDRQAKALGLRSQVEVLPESTSQEELL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  81 ELIDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK14173  77 ELIARLNADPEVDGILVQLPLPPHIDFQRVLEAIDPLKDVDGFHPLNVGRLWMGGEALEPCTPAGVVRLLKHYGIPLAGK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRL--ESG 238
Cdd:PRK14173 157 EVVVVGRSNIVGKPLAALLLREDATVTLAHSKTQDLPAVTRRADVLVVAVGRPHLITPEMVRPGAVVVDVGINRVggNGG 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 556490405 239 K--VVGDVVYEdAAARASYITPVPGGVGPMTVATLIQNTLQACE 280
Cdd:PRK14173 237 RdiLTGDVHPE-VAEVAGALTPVPGGVGPMTVAMLMANTVIAAL 279

PRK14169

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

3-281

4.44e-94

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184550 [Multi-domain] Cd Length: 282 Bit Score: 279.14 E-value: 4.44e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   3 AKIIDGKTIAQQVRSEVAEKVKARKVAGKrAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLEL 82
Cdd:PRK14169   1 ATRLDGRAVSKKILADLKQTVAKLAQQDV-TPTLAVVLVGSDPASEVYVRNKQRRAEDIGVRSLMFRLPEATTQADLLAK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  83 IDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNA 162
Cdd:PRK14169  80 VAELNHDPDVDAILVQLPLPAGLDEQAVIDAIDPDKDVDGFSPVSVGRLWANEPTVVASTPYGIMALLDAYDIDVAGKRV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 163 VVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVG 242
Cdd:PRK14169 160 VIVGRSNIVGRPLAGLMVNHDATVTIAHSKTRNLKQLTKEADILVVAVGVPHFIGADAVKPGAVVIDVGISRGADGKLLG 239

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 556490405 243 DVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEE 281
Cdd:PRK14169 240 DVDEAAVAPIASAITPVPGGVGPMTIASLMAQTVTLAKR 278

PRK14185

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

4-278

1.06e-93

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184556 [Multi-domain] Cd Length: 293 Bit Score: 278.64 E-value: 1.06e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   4 KIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELI 83
Cdd:PRK14185   2 QLIDGKAISAQIKQEIAAEVAEIVAKGGKRPHLAAILVGHDGGSETYVANKVKACEECGFKSSLIRYESDVTEEELLAKV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  84 DTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14185  82 RELNQDDDVDGFIVQLPLPKHISEQKVIEAIDYRKDVDGFHPINVGRMSIGLPCFVSATPNGILELLKRYHIETSGKKCV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 164 VIGASNIVGRPMSMELLLAG----CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESG- 238
Cdd:PRK14185 162 VLGRSNIVGKPMAQLMMQKAypgdCTVTVCHSRSKNLKKECLEADIIIAALGQPEFVKADMVKEGAVVIDVGTTRVPDAt 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 556490405 239 -----KVVGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14185 242 rksgfKLTGDVKFDEVAPKCSYITPVPGGVGPMTIVSLMKNTLLA 286

PRK14178

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

5-278

1.40e-93

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172666 [Multi-domain] Cd Length: 279 Bit Score: 277.88 E-value: 1.40e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   5 IIDGKTIAQQvRSEVaekVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELID 84
Cdd:PRK14178   2 ILDGKAVSEK-RLEL---LKEEIIESGLYPRLATVIVGDDPASQMYVRMKHRACERVGIGSVGIELPGDATTRTVLERIR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  85 TLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVV 164
Cdd:PRK14178  78 RLNEDPDINGILVQLPLPKGVDTERVIAAILPEKDVDGFHPLNLGRLVSGLPGFAPCTPNGIMTLLHEYKISIAGKRAVV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 165 IGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLEsGKVVGDV 244
Cdd:PRK14178 158 VGRSIDVGRPMAALLLNADATVTICHSKTENLKAELRQADILVSAAGKAGFITPDMVKPGATVIDVGINQVN-GKLCGDV 236

                        250       260       270
                 ....*....|....*....|....*....|....
gi 556490405 245 VYEDAAARASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14178 237 DFDAVKEIAGAITPVPGGVGPMTIATLMENTFDA 270

PRK14177

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-282

1.46e-93

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172665 [Multi-domain] Cd Length: 284 Bit Score: 278.01 E-value: 1.46e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   1 MAAKIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14177   1 MSPILLDGKKLSEKIRNEIRETIEERKTKNKRIPKLATILVGNNPASETYVSMKVKACHKVGMGSEMIRLKEQTTTEELL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  81 ELIDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK14177  81 GVIDKLNLDPNVDGILLQHPVPSQIDERAAFDRIALEKDVDGVTTLSFGKLSMGVETYLPCTPYGMVLLLKEYGIDVTGK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINrleSGKv 240
Cdd:PRK14177 161 NAVVVGRSPILGKPMAMLLTEMNATVTLCHSKTQNLPSIVRQADIIVGAVGKPEFIKADWISEGAVLLDAGYN---PGN- 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 556490405 241 VGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEEY 282
Cdd:PRK14177 237 VGDIEISKAKDKSSFYTPVPGGVGPMTIAVLLLQTLYSFKEH 278

PRK14172

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate ...

4-281

3.65e-93

bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional

Pssm-ID: 172660 [Multi-domain] Cd Length: 278 Bit Score: 276.66 E-value: 3.65e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   4 KIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELI 83
Cdd:PRK14172   3 QIINGKEVALKIKEEIKNFVEERKENGLSIPKIASILVGNDGGSIYYMNNQEKVANSLGIDFKKIKLDESISEEDLINEI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  84 DTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14172  83 EELNKDNNVHGIMLQLPLPKHLDEKKITNKIDANKDIDCLTFISVGKFYKGEKCFLPCTPNSVITLIKSLNIDIEGKEVV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 164 VIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLEsGKVVGD 243
Cdd:PRK14172 163 VIGRSNIVGKPVAQLLLNENATVTICHSKTKNLKEVCKKADILVVAIGRPKFIDEEYVKEGAIVIDVGTSSVN-GKITGD 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 556490405 244 VVYEDAAARASYITPVPGGVGPMTVATLIQNtlqACEE 281
Cdd:PRK14172 242 VNFDKVIDKASYITPVPGGVGSLTTTLLIKN---VCEA 276

PLN02897

tetrahydrofolate dehydrogenase/cyclohydrolase, putative

3-284

2.76e-91

tetrahydrofolate dehydrogenase/cyclohydrolase, putative

Pssm-ID: 178485 [Multi-domain] Cd Length: 345 Bit Score: 274.53 E-value: 2.76e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   3 AKIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLEL 82
Cdd:PLN02897  56 TVVIDGNVIAEEIRTKIASEVRKMKKAVGKVPGLAVVLVGQQRDSQTYVRNKIKACEETGIKSLLAELPEDCTEGQILSA 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  83 IDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRA--PRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PLN02897 136 LRKFNEDTSIHGILVQLPLPQHLDESKILNMVRLEKDVDGFHPLNVGNLAMRGrePLFVSCTPKGCVELLIRSGVEIAGK 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESG-- 238
Cdd:PLN02897 216 NAVVIGRSNIVGLPMSLLLQRHDATVSTVHAFTKDPEQITRKADIVIAAAGIPNLVRGSWLKPGAVVIDVGTTPVEDSsc 295

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 556490405 239 ----KVVGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEEYHD 284
Cdd:PLN02897 296 efgyRLVGDVCYEEALGVASAITPVPGGVGPMTITMLLCNTLDAAKRIFL 345

NAD_bind_m-THF_DH_Cyclohyd

cd01080

NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NADP binding ...

116-280

9.59e-90

Pssm-ID: 133448 Cd Length: 168 Bit Score: 264.03 E-value: 9.59e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 116 PDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKN 195
Cdd:cd01080    1 PEKDVDGLHPVNLGRLALGRPGFIPCTPAGILELLKRYGIDLAGKKVVVVGRSNIVGKPLAALLLNRNATVTVCHSKTKN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 196 LRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLE---SGKVVGDVVYEDAAARASYITPVPGGVGPMTVATLI 272
Cdd:cd01080   81 LKEHTKQADIVIVAVGKPGLVKGDMVKPGAVVIDVGINRVPdksGGKLVGDVDFESAKEKASAITPVPGGVGPMTVAMLM 160


                 ....*...
gi 556490405 273 QNTLQACE 280
Cdd:cd01080  161 KNTVEAAK 168

PRK14187

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

5-287

1.64e-89

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172675 [Multi-domain] Cd Length: 294 Bit Score: 268.23 E-value: 1.64e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   5 IIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELID 84
Cdd:PRK14187   4 IIDGKKIANDITEILATCIDDLKRQHNLFPCLIVILVGDDPASQLYVRNKQRKAEMLGLRSETILLPSTISESSLIEKIN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  85 TLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLC--QRAPRLRPCTPRGIVTLLERYNIDTYGLNA 162
Cdd:PRK14187  84 ELNNDDSVHGILVQLPVPNHIDKNLIINTIDPEKDVDGFHNENVGRLFtgQKKNCLIPCTPKGCLYLIKTITRNLSGSDA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 163 VVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESG---K 239
Cdd:PRK14187 164 VVIGRSNIVGKPMACLLLGENCTVTTVHSATRDLADYCSKADILVAAVGIPNFVKYSWIKKGAIVIDVGINSIEEGgvkK 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 556490405 240 VVGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEEYHDVED 287
Cdd:PRK14187 244 FVGDVDFAEVKKKASAITPVPGGVGPMTIAFLMVNTVIAACNQKGIDD 291

PRK14192

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-281

2.71e-89

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 184561 [Multi-domain] Cd Length: 283 Bit Score: 267.10 E-value: 2.71e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   1 MAAKIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14192   1 MMALVLDGKALAKQIEEELSVRVEALKAKTGRTPILATILVGDDPASATYVRMKGNACRRVGMDSLKVELPQETTTEQLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  81 ELIDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGL 160
Cdd:PRK14192  81 AKIEELNANPDVHGILLQHPVPAQIDERACFDAISLAKDVDGVTCLGFGRMAMGEAAYGSATPAGIMRLLKAYNIELAGK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 161 NAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKv 240
Cdd:PRK14192 161 HAVVVGRSAILGKPMAMMLLNANATVTICHSRTQNLPELVKQADIIVGAVGKPELIKKDWIKQGAVVVDAGFHPRDGGG- 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 556490405 241 VGDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACEE 281
Cdd:PRK14192 240 VGDIELQGIEEIASAYTPVPGGVGPMTINTLIRQTVEAAEK 280

PRK14171

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

5-278

1.04e-87

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172659 [Multi-domain] Cd Length: 288 Bit Score: 263.36 E-value: 1.04e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   5 IIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELID 84
Cdd:PRK14171   4 IIDGKALANEILADLKLEIQELKSQTNASPKLAIVLVGDNPASIIYVKNKIKNAHKIGIDTLLVNLSTTIHTNDLISKIN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  85 TLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPR-LRPCTPRGIVTLLERYNIDTYGLNAV 163
Cdd:PRK14171  84 ELNLDNEISGIIVQLPLPSSIDKNKILSAVSPSKDIDGFHPLNVGYLHSGISQgFIPCTALGCLAVIKKYEPNLTGKNVV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 164 VIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVGD 243
Cdd:PRK14171 164 IIGRSNIVGKPLSALLLKENCSVTICHSKTHNLSSITSKADIVVAAIGSPLKLTAEYFNPESIVIDVGINRISGNKIIGD 243

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 556490405 244 VVYEDAAARASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14171 244 VDFENVKSKVKYITPVPGGIGPMTIAFLLKNTVKA 278

PRK14168

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

1-278

5.60e-87

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 237633 [Multi-domain] Cd Length: 297 Bit Score: 261.73 E-value: 5.60e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   1 MAAKIIDGKTIAQQVRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELL 80
Cdd:PRK14168   1 MSAKIIKGTEIREEILEEIRGEVAELKEKYGKVPGLVTILVGESPASLSYVTLKIKTAHRLGFHEIQDNQSVDITEEELL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  81 ELIDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLC--QRAPRLRPCTPRGIVTLLERYNIDTY 158
Cdd:PRK14168  81 ALIDKYNNDDSIHGILVQLPLPKHINEKKVLNAIDPDKDVDGFHPVNVGRLMigGDEVKFLPCTPAGIQEMLVRSGVETS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 159 GLNAVVIGASNIVGRPMSMELLLAG----CTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINR 234
Cdd:PRK14168 161 GAEVVVVGRSNIVGKPIANMMTQKGpganATVTIVHTRSKNLARHCQRADILIVAAGVPNLVKPEWIKPGATVIDVGVNR 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 556490405 235 L----ESGKVV--GDVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQA 278
Cdd:PRK14168 241 VgtneSTGKAIlsGDVDFDAVKEIAGKITPVPGGVGPMTIAMLMRNTLKS 290

PRK14170

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

3-280

7.60e-84

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172658 [Multi-domain] Cd Length: 284 Bit Score: 253.46 E-value: 7.60e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405   3 AKIIDGKTIAQQVRSEVAEKVKARKVAGKRaPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLEL 82
Cdd:PRK14170   2 GEIIDGKKLAKEIQEKVTREVAELVKEGKK-PGLAVVLVGDNQASRTYVRNKQKRTEEAGMKSVLIELPENVTEEKLLSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  83 IDTLNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTYGLNA 162
Cdd:PRK14170  81 VEELNEDKTIHGILVQLPLPEHISEEKVIDTISYDKDVDGFHPVNVGNLFIGKDSFVPCTPAGIIELIKSTGTQIEGKRA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 163 VVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGKVVG 242
Cdd:PRK14170 161 VVIGRSNIVGKPVAQLLLNENATVTIAHSRTKDLPQVAKEADILVVATGLAKFVKKDYIKPGAIVIDVGMDRDENNKLCG 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 556490405 243 DVVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACE 280
Cdd:PRK14170 241 DVDFDDVVEEAGFITPVPGGVGPMTITMLLANTLKAAK 278

PRK14181

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase ...

15-275

9.11e-78

bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD;

Pssm-ID: 172669 [Multi-domain] Cd Length: 287 Bit Score: 237.84 E-value: 9.11e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  15 VRSEVAEKVKARKVAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELIDTLNADKEIDG 94
Cdd:PRK14181   8 AAEHILATIKENISASSTAPGLAVVLIGNDPASEVYVGMKVKKATDLGMVSKAHRLPSDATLSDILKLIHRLNNDPNIHG 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405  95 ILVQLPLPAGIDNVKVLERIAPDKDVDGFHPYNVGR-LCQRAPRLRPCTPRGIVTLLERYNIDTYGLNAVVIGASNIVGR 173
Cdd:PRK14181  88 ILVQLPLPKHLDAQAILQAISPDKDVDGLHPVNMGKlLLGETDGFIPCTPAGIIELLKYYEIPLHGRHVAIVGRSNIVGK 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 174 PMSMELLL----AGCTTTVTHRFTKNLRHHVENADLLIVAVGKPGFIPGEWIKEGAIVVDVGINRLESGK-----VVGDV 244
Cdd:PRK14181 168 PLAALLMQkhpdTNATVTLLHSQSENLTEILKTADIIIAAIGVPLFIKEEMIAEKAVIVDVGTSRVPAANpkgyiLVGDV 247

                        250       260       270
                 ....*....|....*....|....*....|.
gi 556490405 245 VYEDAAARASYITPVPGGVGPMTVATLIQNT 275
Cdd:PRK14181 248 DFNNVVPKCRAITPVPGGVGPMTVAMLMRNT 278

THF_DHG_CYH

pfam00763

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;

6-121

4.57e-63

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain;

Pssm-ID: 459930 [Multi-domain] Cd Length: 115 Bit Score: 194.16 E-value: 4.57e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405    6 IDGKTIAQQVRSEVAEKVKARKvAGKRAPGLAVVLVGSNPASQIYVGSKRKACEEVGFVSRSYDLPETTSEAELLELIDT 85
Cdd:pfam00763   1 IDGKAIAKKIREELKEEVAALK-AGGRKPGLAVILVGDDPASQVYVRNKKKACEEVGIESELIRLPEDTTEEELLALIDK 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 556490405   86 LNADKEIDGILVQLPLPAGIDNVKVLERIAPDKDVD 121
Cdd:pfam00763  80 LNADPSVHGILVQLPLPKHIDEEKVLEAIDPEKDVD 115

NAD_bind_m-THF_DH_Cyclohyd_like

cd05212

NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and ...

140-280

3.65e-31

NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; NAD(P) binding domains of methylene-tetrahydrofolate dehydrogenase (m-THF DH) and m-THF DH/cyclohydrolase bifunctional enzymes (m-THF DH/cyclohydrolase). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. In addition, most DHs also have an associated cyclohydrolase activity which catalyzes its hydrolysis to N10-formyltetrahydrofolate. m-THF DH is typically found as part of a multifunctional protein in eukaryotes. NADP-dependent m-THF DH in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, mono-functional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express a monofunctional DH. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.

Pssm-ID: 133451 Cd Length: 140 Bit Score: 113.37 E-value: 3.65e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 140 PCTPRGIV-------TLLERYNIDTYGLNAVVIGASNIVGRPMSMELLLAGCTTTVTHRFTKNLRHHVENADLLIVAVGK 212
Cdd:cd05212    2 PCTPLFVSpvakavkELLNKEGVRLDGKKVLVVGRSGIVGAPLQCLLQRDGATVYSCDWKTIQLQSKVHDADVVVVGSPK 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 556490405 213 PGFIPGEWIKEGAIVVDVGINRLesgkvvgdvVYEDAAARASYITPVPGGVGPMTVATLIQNTLQACE 280
Cdd:cd05212   82 PEKVPTEWIKPGATVINCSPTKL---------SGDDVKESASLYVPMTGGVGKLTVAMRMQNMVRSVR 140

NAD_bind_m-THF_DH

cd01079

NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of ...

116-283

2.62e-12

NAD binding domain of methylene-tetrahydrofolate dehydrogenase; The NAD-binding domain of methylene-tetrahydrofolate dehydrogenase (m-THF DH). M-THF is a versatile carrier of activated one-carbon units. The major one-carbon folate donors are N-5 methyltetrahydrofolate, N5,N10-m-THF, and N10-formayltetrahydrofolate. The oxidation of metabolic intermediate m-THF to m-THF requires the enzyme m-THF DH. M-THF DH is a component of an unusual monofunctional enzyme; in eukaryotes, m-THF DH is typically found as part of a multifunctional protein. NADP-dependent m-THF DHs in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofunctional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains only the monofunctional DHs from S. cerevisiae and certain bacteria. M-THF DH, like other amino acid DH-like NAD(P)-binding domains, is a member of the Rossmann fold superfamily which includes glutamate, leucine, and phenylalanine DHs, m-THF DH, methylene-tetrahydromethanopterin DH, m-THF DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.

Pssm-ID: 133447 [Multi-domain] Cd Length: 197 Bit Score: 64.37 E-value: 2.62e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 116 PDKDVDGFHPYNVGRLCQ---------RAPRLRPCTPRGIVTLLE---------RYNIDTYGLNAVVIGASNIVGRPMSM 177
Cdd:cd01079    1 PHKDVEGLSHKYIFNLYHnirfldpenRKKSILPCTPLAIVKILEflgiynkilPYGNRLYGKTITIINRSEVVGRPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 178 elLLAGCTTTV-------THRFTKN-----LRHHVEN-----------ADLLIVAVGKPGF-IPGEWIKEGAIVVDV-GI 232
Cdd:cd01079   81 --LLANDGARVysvdingIQVFTRGesirhEKHHVTDeeamtldclsqSDVVITGVPSPNYkVPTELLKDGAICINFaSI 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 556490405 233 NRLEsgkvvgdvvyEDAAARASYITPVpggVGPMTVATLIQNTLQACEEYH 283
Cdd:cd01079  159 KNFE----------PSVKEKASIYVPS---IGKVTIAMLLRNLLRLYHNQH 196

garR

PRK11559

tartronate semialdehyde reductase; Provisional

170-229

2.91e-03

tartronate semialdehyde reductase; Provisional

Pssm-ID: 183197 [Multi-domain] Cd Length: 296 Bit Score: 38.49 E-value: 2.91e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 556490405 170 IVGRPMSMELLLAGCTTTVTHRFTKNLRHHV--------------ENADLLI-----------VAVGKPGFIPGewIKEG 224
Cdd:PRK11559  12 IMGKPMSKNLLKAGYSLVVYDRNPEAVAEVIaagaetastakavaEQCDVIItmlpnsphvkeVALGENGIIEG--AKPG 89


                 ....*
gi 556490405 225 AIVVD 229
Cdd:PRK11559  90 TVVID 94

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01