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Conserved domains on  [gi|567928971|ref|WP_024031376|]
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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Pseudoalteromonas]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
5-146 9.19e-29

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 103.32  E-value: 9.19e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567928971   5 IKIDRYNQKILAILHLTADLTNVELAEQVNLSPSACFQRVKALKEAGYFRTFHADINLEQICEHVFAYMEFTLEDNNLaa 84
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRL-- 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 567928971  85 rRKFLADIHNIPEIMDCMQLSGDIDYISFCCFADIQALNAMC-DRLtgSSQYAIKKLTTRIVL 146
Cdd:COG1522   79 -DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLlERL--AALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
5-146 9.19e-29

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 103.32  E-value: 9.19e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567928971   5 IKIDRYNQKILAILHLTADLTNVELAEQVNLSPSACFQRVKALKEAGYFRTFHADINLEQICEHVFAYMEFTLEDNNLaa 84
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRL-- 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 567928971  85 rRKFLADIHNIPEIMDCMQLSGDIDYISFCCFADIQALNAMC-DRLtgSSQYAIKKLTTRIVL 146
Cdd:COG1522   79 -DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLlERL--AALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 7-111 7.94e-22

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 84.49  E-value: 7.94e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567928971     7 IDRYNQKILAILHLTADLTNVELAEQVNLSPSACFQRVKALKEAGYFRTFHADINLEQICEHVFAYMEFTLEDNNlaARR 86
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPD--KLE 78

                           90       100
                   ....*....|....*....|....*
gi 567928971    87 KFLADIHNIPEIMDCMQLSGDIDYI 111
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYL 103
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-111 8.95e-16

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 70.56  E-value: 8.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567928971   1 MKKTIK-IDRYNQKILAILHLTADLTNVELAEQVNLSPSACFQRVKALKEAGYFRTFHADINLEQICEHVFAYMEFTLED 79
Cdd:PRK11169   5 KKRPGKdLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNR 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 567928971  80 NNLAARRKFLADIHNIPEIMDCMQLSGDIDYI 111
Cdd:PRK11169  85 GAPDVFEQFNAAVQKLEEIQECHLVSGDFDYL 116
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
6-52 2.79e-10

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 52.82  E-value: 2.79e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 567928971    6 KIDRynqKILAILHLTADLTNVELAEQVNLSPSACFQRVKALKEAGY 52
Cdd:pfam13412   1 ETDR---KILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGV 44
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 13-52 1.97e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 41.13  E-value: 1.97e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 567928971  13 KILAILHlTADLTNVELAEQVNLSPSACFQRVKALKEAGY 52
Cdd:cd00090   11 RILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGL 49
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
5-146 9.19e-29

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 103.32  E-value: 9.19e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567928971   5 IKIDRYNQKILAILHLTADLTNVELAEQVNLSPSACFQRVKALKEAGYFRTFHADINLEQICEHVFAYMEFTLEDNNLaa 84
Cdd:COG1522    1 MELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRL-- 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 567928971  85 rRKFLADIHNIPEIMDCMQLSGDIDYISFCCFADIQALNAMC-DRLtgSSQYAIKKLTTRIVL 146
Cdd:COG1522   79 -DEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLlERL--AALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 7-111 7.94e-22

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 84.49  E-value: 7.94e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567928971     7 IDRYNQKILAILHLTADLTNVELAEQVNLSPSACFQRVKALKEAGYFRTFHADINLEQICEHVFAYMEFTLEDNNlaARR 86
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPD--KLE 78

                           90       100
                   ....*....|....*....|....*
gi 567928971    87 KFLADIHNIPEIMDCMQLSGDIDYI 111
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYL 103
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-111 8.95e-16

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 70.56  E-value: 8.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567928971   1 MKKTIK-IDRYNQKILAILHLTADLTNVELAEQVNLSPSACFQRVKALKEAGYFRTFHADINLEQICEHVFAYMEFTLED 79
Cdd:PRK11169   5 KKRPGKdLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNR 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 567928971  80 NNLAARRKFLADIHNIPEIMDCMQLSGDIDYI 111
Cdd:PRK11169  85 GAPDVFEQFNAAVQKLEEIQECHLVSGDFDYL 116
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
6-52 2.79e-10

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 52.82  E-value: 2.79e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 567928971    6 KIDRynqKILAILHLTADLTNVELAEQVNLSPSACFQRVKALKEAGY 52
Cdd:pfam13412   1 ETDR---KILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGV 44
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
8-48 5.38e-08

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 46.98  E-value: 5.38e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 567928971    8 DRYNQKILAILHLTADLTNVELAEQVNLSPSACFQRVKALK 48
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 86-148 2.20e-07

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 45.98  E-value: 2.20e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 567928971   86 RKFLADIHNIPEIMDCMQLSGDIDYISFCCFADIQALNAMCDRLTGSSQyAIKKLTTRIVLER 148
Cdd:pfam01037  12 EEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLP-GVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 13-52 1.97e-05

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 41.13  E-value: 1.97e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 567928971  13 KILAILHlTADLTNVELAEQVNLSPSACFQRVKALKEAGY 52
Cdd:cd00090   11 RILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGL 49
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-65 3.74e-04

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 38.92  E-value: 3.74e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 567928971   1 MKKTIKIDRYNQKILAILHLTADLTNVELAEQVNLSPSACFQRVKALKEAGYFRTFHADINLEQI 65
Cdd:PRK11179   1 MMENYQIDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQL 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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