|
Name |
Accession |
Description |
Interval |
E-value |
| AcnA |
COG1048 |
Aconitase A [Energy production and conversion]; Aconitase A is part of the Pathway/BioSystem: ... |
1-912 |
0e+00 |
|
Aconitase A [Energy production and conversion]; Aconitase A is part of the Pathway/BioSystem: Lysine biosynthesisTCA cycle
Pssm-ID: 440669 [Multi-domain] Cd Length: 891 Bit Score: 1679.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 1 MNSFDTQQQLTINGEQYHIHSLKGL---GDKAKRLPFSLKVLLENLLRNEDGVNIKEQDIQALLDWDPKAKPSAEVAFTP 77
Cdd:COG1048 2 MDSFKARKTLTVGGKPYTYYSLPALeeaGGDISRLPYSLKILLENLLRNEDGETVTEEDIKALANWLPKARGDDEIPFRP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 78 ARVVMQDFTGVPAIVDLAAMRDAMEKLGGDPAKINPLSPAELVIDHSVQVDGYGDDGAFDLNAKLEYERNKERYEFLRWG 157
Cdd:COG1048 82 ARVLMQDFTGVPAVVDLAAMRDAVARLGGDPKKINPLVPVDLVIDHSVQVDYFGTPDALEKNLELEFERNRERYQFLKWG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 158 QTAFDNLKVVPPATGIVHQVNLEFLARVVFNDSENGKSIAYPDTLVGTDSHTTMINglgvlgwgvggIEAEAAMLGQPIS 237
Cdd:COG1048 162 QQAFDNFRVVPPGTGIVHQVNLEYLAFVVWTREEDGETVAYPDTLVGTDSHTTMINglgvlgwgvggIEAEAAMLGQPVS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 238 LLIPQVVGFKLNGRLPEGTTATDLVLTVTEMLRNHGVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGIFPIDDET 317
Cdd:COG1048 242 MLIPEVVGVKLTGKLPEGVTATDLVLTVTEMLRKKGVVGKFVEFFGPGLASLSLADRATIANMAPEYGATCGFFPVDEET 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 318 INYLRLTNRDEDHLKLIEDYAKHQGLWRHEGD-EAHYTDTLELKLDDVVPSLAGPKRPQDRITLDKAGDVIGQHLKGFQD 396
Cdd:COG1048 322 LDYLRLTGRSEEQIELVEAYAKAQGLWRDPDApEPYYSDVLELDLSTVEPSLAGPKRPQDRIPLSDLKEAFRAALAAPVG 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 397 ERMARRdksdieeariesegpttnpdepvdeaqfmgaAKVKFKGQEFELNDGACVIAAITSCTNTSNPSVILAAGLVAQK 476
Cdd:COG1048 402 EELDKP-------------------------------VRVEVDGEEFELGHGAVVIAAITSCTNTSNPSVMIAAGLLAKK 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 477 AKQLGINVKPWVKTSLAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTCIGNSGPLADEISEAIQKHKLVVSSILSGN 556
Cdd:COG1048 451 AVEKGLKVKPWVKTSLAPGSKVVTDYLERAGLLPYLEALGFNVVGYGCTTCIGNSGPLPPEISEAIEENDLVVAAVLSGN 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 557 RNFEGRIHQDVKMNFLASPPLVVAYAIAGRTDIDVYNEPLAQDENGNDIYLKNIWPSVSEVSELVQKTVTREMFEKSYAN 636
Cdd:COG1048 531 RNFEGRIHPDVKANFLASPPLVVAYALAGTVDIDLTTDPLGTDKDGKPVYLKDIWPSGEEIPAAVFKAVTPEMFRARYAD 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 637 VYEGDSRWQKIQIPDGKLYDWDDGSTYIKKAPFFEGMSVEPPGVPTIEGARCLAKLGDSVTTDHISPAGAIKAEAPAGIY 716
Cdd:COG1048 611 VFDGDERWQALEVPAGELYDWDPDSTYIRRPPFFEGLQLEPEPFKDIKGARVLAKLGDSITTDHISPAGAIKADSPAGRY 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 717 LQEKGVEKAQFNSYGSRRGNHEVMMRGTFANVRLKNLLAPGTEGGVTRTQPDDKLASIYDAAMEYEKSNTPLIVLAGKEY 796
Cdd:COG1048 691 LLEHGVEPKDFNSYGSRRGNHEVMMRGTFANIRIKNLLAPGTEGGYTKHQPTGEVMSIYDAAMRYKAEGTPLVVLAGKEY 770
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 797 GTGSSRDWAAKGSLLLGVKAVVAQSYERIHRSNLIGMGVLPLQFKEGESHESLNLTGQEQFDIEGLYDKT---NEVSIIA 873
Cdd:COG1048 771 GTGSSRDWAAKGTRLLGVKAVIAESFERIHRSNLVGMGVLPLQFPEGESAESLGLTGDETFDIEGLDEGLapgKTVTVTA 850
|
890 900 910
....*....|....*....|....*....|....*....
gi 567929592 874 TNAEGKKVSFSADVRIDTPKEWDYYKHGGILQYVLRNML 912
Cdd:COG1048 851 TRADGSTEEFPVLHRIDTPVEVEYYRAGGILQYVLRQLL 889
|
|
| PRK09277 |
PRK09277 |
aconitate hydratase AcnA; |
1-912 |
0e+00 |
|
aconitate hydratase AcnA;
Pssm-ID: 236445 [Multi-domain] Cd Length: 888 Bit Score: 1674.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 1 MNSFDTQQQLTINGEQYHIHSLKGLGDKA----KRLPFSLKVLLENLLRNEDGVNIKEQDIQALLDWDPKAKPSAEVAFT 76
Cdd:PRK09277 4 TDSFKARKTLEVGGKSYDYYSLRALEAKGlgdiSRLPYSLRVLLENLLRNEDGRSVTEEDIEALAEWLPKAKPDREIPFR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 77 PARVVMQDFTGVPAIVDLAAMRDAMEKLGGDPAKINPLSPAELVIDHSVQVDGYGDDGAFDLNAKLEYERNKERYEFLRW 156
Cdd:PRK09277 84 PARVVMQDFTGVPAVVDLAAMRDAIADLGGDPAKINPLVPVDLVIDHSVQVDYFGTPDAFEKNVELEFERNEERYQFLKW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 157 GQTAFDNLKVVPPATGIVHQVNLEFLARVVFNDsENGKSIAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPI 236
Cdd:PRK09277 164 GQKAFDNFRVVPPGTGICHQVNLEYLAPVVWTR-EDGELVAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 237 SLLIPQVVGFKLNGRLPEGTTATDLVLTVTEMLRNHGVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGIFPIDDE 316
Cdd:PRK09277 243 SMLIPEVVGVKLTGKLPEGVTATDLVLTVTEMLRKKGVVGKFVEFFGEGLASLSLADRATIANMAPEYGATCGFFPIDEE 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 317 TINYLRLTNRDEDHLKLIEDYAKHQGLWRHEGDEAHYTDTLELKLDDVVPSLAGPKRPQDRITLDKAgdvigqhlkgfqd 396
Cdd:PRK09277 323 TLDYLRLTGRDEEQVALVEAYAKAQGLWRDPLEEPVYTDVLELDLSTVEPSLAGPKRPQDRIPLSDV------------- 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 397 ermarrdKSDIEEARIESEGPTTNPDEPVdeaqfmgaakvkfkGQEFELNDGACVIAAITSCTNTSNPSVILAAGLVAQK 476
Cdd:PRK09277 390 -------KEAFAKSAELGVQGFGLDEAEE--------------GEDYELPDGAVVIAAITSCTNTSNPSVMIAAGLLAKK 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 477 AKQLGINVKPWVKTSLAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTCIGNSGPLADEISEAIQKHKLVVSSILSGN 556
Cdd:PRK09277 449 AVEKGLKVKPWVKTSLAPGSKVVTDYLEKAGLLPYLEALGFNLVGYGCTTCIGNSGPLPPEIEKAINDNDLVVTAVLSGN 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 557 RNFEGRIHQDVKMNFLASPPLVVAYAIAGRTDIDVYNEPLAQDENGNDIYLKNIWPSVSEVSELVQKTVTREMFEKSYAN 636
Cdd:PRK09277 529 RNFEGRIHPLVKANYLASPPLVVAYALAGTVDIDLEKDPLGTDKDGNPVYLKDIWPSDEEIDAVVAKAVKPEMFRKEYAD 608
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 637 VYEGDSRWQKIQIPDGKLYDWDDGSTYIKKAPFFEGMSVEPPGVPTIEGARCLAKLGDSVTTDHISPAGAIKAEAPAGIY 716
Cdd:PRK09277 609 VFEGDERWNAIEVPEGPLYDWDPDSTYIRNPPYFEGMLAEPGPVRDIKGARVLALLGDSITTDHISPAGAIKADSPAGKY 688
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 717 LQEKGVEKAQFNSYGSRRGNHEVMMRGTFANVRLKNLLAPGTEGGVTRTQPDDKLASIYDAAMEYEKSNTPLIVLAGKEY 796
Cdd:PRK09277 689 LLEHGVEPKDFNSYGSRRGNHEVMMRGTFANIRIRNEMVPGVEGGYTRHFPEGEVMSIYDAAMKYKEEGTPLVVIAGKEY 768
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 797 GTGSSRDWAAKGSLLLGVKAVVAQSYERIHRSNLIGMGVLPLQFKEGESHESLNLTGQEQFDIEGLYDKT--NEVSIIAT 874
Cdd:PRK09277 769 GTGSSRDWAAKGTRLLGVKAVIAESFERIHRSNLVGMGVLPLQFKPGESRKTLGLDGTETFDIEGLEDLKpgATVTVVIT 848
|
890 900 910
....*....|....*....|....*....|....*...
gi 567929592 875 NAEGKKVSFSADVRIDTPKEWDYYKHGGILQYVLRNML 912
Cdd:PRK09277 849 RADGEVVEFPVLCRIDTAVEVDYYRNGGILQYVLRDLL 886
|
|
| acnA |
PRK12881 |
aconitate hydratase AcnA; |
1-912 |
0e+00 |
|
aconitate hydratase AcnA;
Pssm-ID: 237246 [Multi-domain] Cd Length: 889 Bit Score: 1420.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 1 MNSFDTQQQLTINGEQYHIHSL----KGLGDKAKRLPFSLKVLLENLLRNEDGVNIKEQDIQALLDWDPKAKPSAEVAFT 76
Cdd:PRK12881 3 HNLHKTLKEFDVGGKTYKFYSLpalgKELGGDLARLPVSLRVLLENLLRNEDGKKVTEEHLEALANWLPERKSDDEIPFV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 77 PARVVMQDFTGVPAIVDLAAMRDAMEKLGGDPAKINPLSPAELVIDHSVQVDGYGDDGAFDLNAKLEYERNKERYEFLRW 156
Cdd:PRK12881 83 PARVVMQDFTGVPALVDLAAMRDAAAEAGGDPAKINPLVPVDLVVDHSVAVDYFGQKDALDLNMKIEFQRNAERYQFLKW 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 157 GQTAFDNLKVVPPATGIVHQVNLEFLARVVFNDSENGKSIAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPI 236
Cdd:PRK12881 163 GMQAFDNFRVVPPGTGIMHQVNLEYLARVVHTKEDDGDTVAYPDTLVGTDSHTTMINGIGVLGWGVGGIEAEAVMLGQPV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 237 SLLIPQVVGFKLNGRLPEGTTATDLVLTVTEMLRNHGVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGIFPIDDE 316
Cdd:PRK12881 243 YMLIPDVVGVELTGKLREGVTATDLVLTVTEMLRKEGVVGKFVEFFGEGVASLTLGDRATIANMAPEYGATMGFFPVDEQ 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 317 TINYLRLTNRDEDHLKLIEDYAKHQGLWRHEGDEAHYTDTLELKLDDVVPSLAGPKRPQDRITLdkaGDViGQHLKGFQd 396
Cdd:PRK12881 323 TLDYLRLTGRTEAQIALVEAYAKAQGLWGDPKAEPRYTRTLELDLSTVAPSLAGPKRPQDRIAL---GNV-KSAFSDLF- 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 397 ermarrdksdieeariesegpttnpDEPVDEAQFMGAAKvkfKGQEFELNDGACVIAAITSCTNTSNPSVILAAGLVAQK 476
Cdd:PRK12881 398 -------------------------SKPVAENGFAKKAQ---TSNGVDLPDGAVAIAAITSCTNTSNPSVLIAAGLLAKK 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 477 AKQLGINVKPWVKTSLAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTCIGNSGPLADEISEAIQKHKLVVSSILSGN 556
Cdd:PRK12881 450 AVERGLTVKPWVKTSLAPGSKVVTEYLERAGLLPYLEKLGFGIVGYGCTTCIGNSGPLTPEIEQAITKNDLVAAAVLSGN 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 557 RNFEGRIHQDVKMNFLASPPLVVAYAIAGRTDIDVYNEPLAQDENGNDIYLKNIWPSVSEVSELVQKTVTREMFEKSYAN 636
Cdd:PRK12881 530 RNFEGRIHPNIKANFLASPPLVVAYALAGTVRRDLMTEPLGKGKDGRPVYLKDIWPSSAEIDALVAFAVDPEDFRKNYAE 609
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 637 VYEGDSRWQKIQIPDGKLYDWDDGSTYIKKAPFFEGMSVEPPGVPTIEGARCLAKLGDSVTTDHISPAGAIKAEAPAGIY 716
Cdd:PRK12881 610 VFKGSELWAAIEAPDGPLYDWDPKSTYIRRPPFFDFSMGPAASIATVKGARPLAVLGDSITTDHISPAGAIKADSPAGKY 689
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 717 LQEKGVEKAQFNSYGSRRGNHEVMMRGTFANVRLKNLLAPGTEGGVTRTQPDDKLASIYDAAMEYEKSNTPLIVLAGKEY 796
Cdd:PRK12881 690 LKENGVPKADFNSYGSRRGNHEVMMRGTFANVRIKNLMIPGKEGGLTLHQPSGEVLSIYDAAMRYQAAGTPLVVIAGEEY 769
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 797 GTGSSRDWAAKGSLLLGVKAVVAQSYERIHRSNLIGMGVLPLQFKEGESHESLNLTGQEQFDIEGLYDKTN---EVSIIA 873
Cdd:PRK12881 770 GTGSSRDWAAKGTRLLGVKAVIAESFERIHRSNLVGMGVLPLQFKGGDSRQSLGLTGGETFDIEGLPGEIKprqDVTLVI 849
|
890 900 910
....*....|....*....|....*....|....*....
gi 567929592 874 TNAEGKKVSFSADVRIDTPKEWDYYKHGGILQYVLRNML 912
Cdd:PRK12881 850 HRADGSTERVPVLCRIDTPIEVDYYKAGGILPYVLRQLL 888
|
|
| aconitase_1 |
TIGR01341 |
aconitate hydratase 1; This model represents one form of the TCA cycle enzyme aconitate ... |
15-912 |
0e+00 |
|
aconitate hydratase 1; This model represents one form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It is found in bacteria, archaea, and eukaryotic cytosol. It has been shown to act also as an iron-responsive element binding protein in animals and may have the same role in other eukaryotes. [Energy metabolism, TCA cycle]
Pssm-ID: 273562 [Multi-domain] Cd Length: 876 Bit Score: 1331.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 15 EQYHIHSLKGL---GDKAKRLPFSLKVLLENLLRNEDGVNIKEQDIQALLDWDPKAKPSAEVAFTPARVVMQDFTGVPAI 91
Cdd:TIGR01341 1 KTYYYYSLKALeesGGKISKLPYSIRILLESVLRNLDGFSITEEDIENILKWKIGEVADTEIAFKPARVVMQDFTGVPAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 92 VDLAAMRDAMEKLGGDPAKINPLSPAELVIDHSVQVDGYGDDGAFDLNAKLEYERNKERYEFLRWGQTAFDNLKVVPPAT 171
Cdd:TIGR01341 81 VDLAAMREAMKNLGGDPKKINPLVPVDLVIDHSVQVDYYGTEYALEFNMELEFERNLERYQFLKWAQKAFRNFRVVPPGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 172 GIVHQVNLEFLARVVFNDSENGKSIAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPISLLIPQVVGFKLNGR 251
Cdd:TIGR01341 161 GIIHQVNLEYLATVVFKAEVDGELTAYPDSLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPYYMNVPEVIGVKLTGK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 252 LPEGTTATDLVLTVTEMLRNHGVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGIFPIDDETINYLRLTNRDEDHL 331
Cdd:TIGR01341 241 LQEGVTATDLVLTVTQMLRKKGVVGKFVEFFGPGLSELSLADRATIANMAPEYGATCGFFPIDDVTLQYLRLTGRDGDHV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 332 KLIEDYAKHQGLWRHEGDEAHYTDTLELKLDDVVPSLAGPKRPQDRITLDkagDVIGQHLKgfqdermarrdksdieear 411
Cdd:TIGR01341 321 ELVEKYARAQGLFYDDSEEPRYTDVVELDLSDVEPSVAGPKRPQDRIPLR---EVKAKFSK------------------- 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 412 iESEGPTTNPDEPVD-EAQFMgaakvKFKGQEFELNDGACVIAAITSCTNTSNPSVILAAGLVAQKAKQLGINVKPWVKT 490
Cdd:TIGR01341 379 -ELEKNGGDKGFTLRkEPLKK-----KVNGQNKQLEDGAVVIAAITSCTNTSNPSVMLGAGLLAKKAVELGLKVPPYVKT 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 491 SLAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTCIGNSGPLADEISEAIQKHKLVVSSILSGNRNFEGRIHQDVKMN 570
Cdd:TIGR01341 453 SLAPGSKVVTDYLAESGLLPYLEELGFNLVGYGCTTCIGNSGPLPKYVEEAIKKNDLEVYAVLSGNRNFEGRIHPLVKGN 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 571 FLASPPLVVAYAIAGRTDIDVYNEPLAQDENGNDIYLKNIWPSVSEVSELVQKTVTREMFEKSYANVYEGDSRWQKIQIP 650
Cdd:TIGR01341 533 YLASPPLVVAYALAGNIDINLYTEPIGTDKDGKPVYLRDIWPSNKEIAAYVNMAVKPEMFKKEYENIFEGNERWNSIKTP 612
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 651 DGKLYDWDDGSTYIKKAPFFEGMSVEPPGVPTIEGARCLAKLGDSVTTDHISPAGAIKAEAPAGIYLQEKGVEKAQFNSY 730
Cdd:TIGR01341 613 SGDTYSWDEKSTYIRLPPFFEEMKQDPEEVEDIKGARILLLLGDSITTDHISPAGSITKDSPAGKYLQERGVSRRDFNSY 692
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 731 GSRRGNHEVMMRGTFANVRLKNLLAPGTEGGVTRTQPDDKLASIYDAAMEYEKSNTPLIVLAGKEYGTGSSRDWAAKGSL 810
Cdd:TIGR01341 693 GSRRGNHEVMMRGTFANIRIKNLMVKGKEGGYTVHFPDGKVASVYDAAMQYKKEGTPLVVIAGKEYGSGSSRDWAAKGTK 772
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 811 LLGVKAVVAQSYERIHRSNLIGMGVLPLQFKEGESHESLNLTGQEQFDIEGL--YDKTNEVSIIATNAEGKKVSFSADVR 888
Cdd:TIGR01341 773 LLGVKAVIAESFERIHRSNLVGMGVIPLQFPQGEDAETLGLTGDETIDIDGIkdLKPGKEVTVTFTNSKGEKITFKCVLR 852
|
890 900
....*....|....*....|....
gi 567929592 889 IDTPKEWDYYKHGGILQYVLRNML 912
Cdd:TIGR01341 853 IDTEVELDYYKHGGILQYVLRKFL 876
|
|
| PTZ00092 |
PTZ00092 |
aconitate hydratase-like protein; Provisional |
2-912 |
0e+00 |
|
aconitate hydratase-like protein; Provisional
Pssm-ID: 240263 [Multi-domain] Cd Length: 898 Bit Score: 1311.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 2 NSFDTQQQLTINGEQYHIHSLKGLGD-KAKRLPFSLKVLLENLLRNEDGVNIKEQDIQALLDWDPKAKPSAEVAFTPARV 80
Cdd:PTZ00092 14 NPFEKVLKTLKDGGSYKYYSLNELHDpRLKKLPYSIRVLLESAVRNCDEFDVTSKDVENILNWEENSKKQIEIPFKPARV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 81 VMQDFTGVPAIVDLAAMRDAMEKLGGDPAKINPLSPAELVIDHSVQVDGYGDDGAFDLNAKLEYERNKERYEFLRWGQTA 160
Cdd:PTZ00092 94 LLQDFTGVPAVVDLAAMRDAMKRLGGDPAKINPLVPVDLVIDHSVQVDFSRSPDALELNQEIEFERNLERFEFLKWGSKA 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 161 FDNLKVVPPATGIVHQVNLEFLARVVFNDSengkSIAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPISLLI 240
Cdd:PTZ00092 174 FKNLLIVPPGSGIVHQVNLEYLARVVFNKD----GLLYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQPISMVL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 241 PQVVGFKLNGRLPEGTTATDLVLTVTEMLRNHGVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGIFPIDDETINY 320
Cdd:PTZ00092 250 PEVVGFKLTGKLSEHVTATDLVLTVTSMLRKRGVVGKFVEFYGPGVKTLSLADRATIANMAPEYGATMGFFPIDEKTLDY 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 321 LRLTNRDEDHLKLIEDYAKHQGLWRHEGDEAHYTDTLELKLDDVVPSLAGPKRPQDRITLDkagDVigqhlkgfqderma 400
Cdd:PTZ00092 330 LKQTGRSEEKVELIEKYLKANGLFRTYAEQIEYSDVLELDLSTVVPSVAGPKRPHDRVPLS---DL-------------- 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 401 RRDKSDIEEARIESEGPTTNPDEPVDEAQFMgaakvkFKGQEFELNDGACVIAAITSCTNTSNPSVILAAGLVAQKAKQL 480
Cdd:PTZ00092 393 KKDFTACLSAPVGFKGFGIPEEKHEKKVKFT------YKGKEYTLTHGSVVIAAITSCTNTSNPSVMLAAGLLAKKAVEK 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 481 GINVKPWVKTSLAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTCIGNSGPLADEISEAIQKHKLVVSSILSGNRNFE 560
Cdd:PTZ00092 467 GLKVPPYIKTSLSPGSKVVTKYLEASGLLKYLEKLGFYTAGYGCMTCIGNSGDLDPEVSEAITNNDLVAAAVLSGNRNFE 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 561 GRIHQDVKMNFLASPPLVVAYAIAGRTDIDVYNEPLAQDENGNDIYLKNIWPSVSEVSELVQKTVTREMFEKSYANVYEG 640
Cdd:PTZ00092 547 GRVHPLTRANYLASPPLVVAYALAGRVNIDFETEPLGSDKTGKPVFLRDIWPSREEIQALEAKYVKPEMFKEVYSNITQG 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 641 DSRWQKIQIPDGKLYDWDDGSTYIKKAPFFEGMSVEPPGVPTIEGARCLAKLGDSVTTDHISPAGAIKAEAPAGIYLQEK 720
Cdd:PTZ00092 627 NKQWNELQVPKGKLYEWDEKSTYIHNPPFFQTMELEPPPIKSIENAYCLLNLGDSITTDHISPAGNIAKNSPAAKYLMER 706
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 721 GVEKAQFNSYGSRRGNHEVMMRGTFANVRLKNLLAPGTeGGVTRTQPDDKLASIYDAAMEYEKSNTPLIVLAGKEYGTGS 800
Cdd:PTZ00092 707 GVERKDFNTYGARRGNDEVMVRGTFANIRLINKLCGKV-GPNTVHVPTGEKMSIYDAAEKYKQEGVPLIVLAGKEYGSGS 785
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 801 SRDWAAKGSLLLGVKAVVAQSYERIHRSNLIGMGVLPLQFKEGESHESLNLTGQEQFDIEGLYD--KTNEVsIIATNAEG 878
Cdd:PTZ00092 786 SRDWAAKGPYLQGVKAVIAESFERIHRSNLVGMGILPLQFLNGENADSLGLTGKEQFSIDLNSGelKPGQD-VTVKTDTG 864
|
890 900 910
....*....|....*....|....*....|....
gi 567929592 879 KkvSFSADVRIDTPKEWDYYKHGGILQYVLRNML 912
Cdd:PTZ00092 865 K--TFDTILRIDTEVEVEYFKHGGILQYVLRKLV 896
|
|
| PLN00070 |
PLN00070 |
aconitate hydratase |
14-912 |
0e+00 |
|
aconitate hydratase
Pssm-ID: 215047 [Multi-domain] Cd Length: 936 Bit Score: 1104.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 14 GEQYHIHSLKGLGD-KAKRLPFSLKVLLENLLRNEDGVNIKEQDIQALLDWDPKAKPSAEVAFTPARVVMQDFTGVPAIV 92
Cdd:PLN00070 58 GEFGKYYSLPALNDpRIDKLPYSIRILLESAIRNCDNFQVTKEDVEKIIDWENTSPKQVEIPFKPARVLLQDFTGVPAVV 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 93 DLAAMRDAMEKLGGDPAKINPLSPAELVIDHSVQVDGYGDDGAFDLNAKLEYERNKERYEFLRWGQTAFDNLKVVPPATG 172
Cdd:PLN00070 138 DLACMRDAMNNLGGDPNKINPLVPVDLVIDHSVQVDVARSENAVQANMELEFQRNKERFAFLKWGSTAFQNMLVVPPGSG 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 173 IVHQVNLEFLARVVFNDsengKSIAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPISLLIPQVVGFKLNGRL 252
Cdd:PLN00070 218 IVHQVNLEYLGRVVFNT----DGILYPDSVVGTDSHTTMIDGLGVAGWGVGGIEAEAAMLGQPMSMVLPGVVGFKLSGKL 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 253 PEGTTATDLVLTVTEMLRNHGVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGIFPIDDETINYLRLTNRDEDHLK 332
Cdd:PLN00070 294 RDGVTATDLVLTVTQMLRKHGVVGKFVEFYGEGMSELSLADRATIANMSPEYGATMGFFPVDHVTLQYLKLTGRSDETVA 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 333 LIEDYAKHQGL---WRHEGDEAHYTDTLELKLDDVVPSLAGPKRPQDRITLdkagdvigqhlkgfqdeRMARRDKSDIEE 409
Cdd:PLN00070 374 MIEAYLRANKMfvdYNEPQQERVYSSYLELDLEDVEPCISGPKRPHDRVPL-----------------KEMKADWHSCLD 436
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 410 ARIESEGPTTnPDEPVDEAqfmgaAKVKFKGQEFELNDGACVIAAITSCTNTSNPSVILAAGLVAQKAKQLGINVKPWVK 489
Cdd:PLN00070 437 NKVGFKGFAV-PKEAQSKV-----AKFSFHGQPAELRHGSVVIAAITSCTNTSNPSVMLGAGLVAKKACELGLEVKPWIK 510
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 490 TSLAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTCIGNSGPLADEISEAIQKHKLVVSSILSGNRNFEGRIHQDVKM 569
Cdd:PLN00070 511 TSLAPGSGVVTKYLLKSGLQKYLNQQGFHIVGYGCTTCIGNSGELDESVASAITENDIVAAAVLSGNRNFEGRVHPLTRA 590
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 570 NFLASPPLVVAYAIAGRTDIDVYNEPLAQDENGNDIYLKNIWPSVSEVSELVQKTVTREMFEKSYANVYEGDSRWQKIQI 649
Cdd:PLN00070 591 NYLASPPLVVAYALAGTVDIDFEKEPIGTGKDGKDVFFRDIWPSNEEVAEVVQSSVLPDMFKSTYEAITKGNPMWNQLSV 670
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 650 PDGKLYDWDDGSTYIKKAPFFEGMSVEPPGVPTIEGARCLAKLGDSVTTDHISPAGAIKAEAPAGIYLQEKGVEKAQFNS 729
Cdd:PLN00070 671 PSGTLYSWDPKSTYIHEPPYFKNMTMSPPGPHGVKDAYCLLNFGDSITTDHISPAGSIHKDSPAAKYLMERGVDRKDFNS 750
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 730 YGSRRGNHEVMMRGTFANVRLKNLLAPGTEGGVTRTQPDDKLASIYDAAMEYEKSNTPLIVLAGKEYGTGSSRDWAAKGS 809
Cdd:PLN00070 751 YGSRRGNDEIMARGTFANIRIVNKLLKGEVGPKTVHIPTGEKLSVFDAAMKYKSEGHDTIILAGAEYGSGSSRDWAAKGP 830
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 810 LLLGVKAVVAQSYERIHRSNLIGMGVLPLQFKEGESHESLNLTGQEQFDIEgLYDKTNEV----SIIATNAEGKkvSFSA 885
Cdd:PLN00070 831 MLLGVKAVIAKSFERIHRSNLVGMGIIPLCFKSGEDADTLGLTGHERYTID-LPSNISEIkpgqDVTVTTDNGK--SFTC 907
|
890 900
....*....|....*....|....*..
gi 567929592 886 DVRIDTPKEWDYYKHGGILQYVLRNML 912
Cdd:PLN00070 908 TLRFDTEVELAYFDHGGILPYVIRNLI 934
|
|
| AcnA_IRP |
cd01586 |
Aconitase A catalytic domain; Aconitase A catalytic domain. This is the major form of the TCA ... |
79-586 |
0e+00 |
|
Aconitase A catalytic domain; Aconitase A catalytic domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydrolyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group also includes sequences that have been shown to act as an iron-responsive element (IRE) binding protein in animals and may have the same role in other eukaryotes.
Pssm-ID: 153136 Cd Length: 404 Bit Score: 727.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 79 RVVMQDFTGVPAIVDLAAMRDAMEKLGGDPAKINPLSPAELVIDHSVQVDGYGDDGAFDLNAKLEYERNKERYEFLRWGQ 158
Cdd:cd01586 1 RVILQDFTGVPAVVDLAAMRDAVKRLGGDPEKINPLIPVDLVIDHSVQVDFYGTADALAKNMKLEFERNRERYEFLKWGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 159 TAFDNLKVVPPATGIVHQVNLEFLARVVFNDSENGKSIAYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPISL 238
Cdd:cd01586 81 KAFKNLRVVPPGTGIIHQVNLEYLARVVFTSEEDGDGVAYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQPISM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 239 LIPQVVGFKLNGRLPEGTTATDLVLTVTEMLRNHGVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGIFPIDdeti 318
Cdd:cd01586 161 LLPEVVGVKLTGKLRPGVTATDLVLTVTQMLRKVGVVGKFVEFFGPGVAKLSVADRATIANMAPEYGATCGFFPVD---- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 319 nylrltnrdedhlkliedyakhqglwrhegdeahyTDTLELKLDDVVPSLAGPKRPQDRITLdkagdvigqhlkgfqder 398
Cdd:cd01586 237 -----------------------------------TQVVELDLSTVEPSVSGPKRPQDRVPL------------------ 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 399 marrdksdieeariesegpttnpdepvdeaqfmgaakvkfkgqefelnDGACVIAAITSCTNTSNPSVILAAGLVAQKAK 478
Cdd:cd01586 264 ------------------------------------------------HGSVVIAAITSCTNTSNPSVMLAAGLLAKKAV 295
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 479 QLGINVKPWVKTSLAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTCIGNSGPLADEISEAIQKHKLVVSSILSGNRN 558
Cdd:cd01586 296 ELGLKVKPYVKTSLAPGSRVVTKYLEASGLLPYLEKLGFHVVGYGCTTCIGNSGPLPEEVEEAIKENDLVVAAVLSGNRN 375
|
490 500
....*....|....*....|....*...
gi 567929592 559 FEGRIHQDVKMNFLASPPLVVAYAIAGR 586
Cdd:cd01586 376 FEGRIHPLVRANYLASPPLVVAYALAGT 403
|
|
| Aconitase |
pfam00330 |
Aconitase family (aconitate hydratase); |
63-585 |
0e+00 |
|
Aconitase family (aconitate hydratase);
Pssm-ID: 459764 Cd Length: 460 Bit Score: 618.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 63 WDPKA--KPSAEVAFTPARVVMQDFTGVPAIVDLAAMRDAMEKLGGDPAKINPLSPAELVIDHSvqvdgygdDGAFDLNA 140
Cdd:pfam00330 4 WDAHLveELDGSLLYIPDRVLMHDVTSPQAFVDLRAAGRAVRRPGGTPATIDHLVPTDLVIDHA--------PDALDKNI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 141 KLEYERNKERYEFLRWGQTAFdNLKVVPPATGIVHQVNLEFLarvvfndsengksIAYPD-TLVGTDSHTTMINglgvlg 219
Cdd:pfam00330 76 EDEISRNKEQYDFLEWNAKKF-GIRFVPPGQGIVHQVGLEYG-------------LALPGmTIVGTDSHTTTHGglgala 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 220 wgvggIEAEAAMLGQPISLLIPQVVGFKLNGRLPEGTTATDLVLTVTEMLRNHGVVGKFVEFYGDGLADLPLADRATIAN 299
Cdd:pfam00330 142 fgvggSEAEHVLATQPLEMKKPKVVGVKLTGKLPPGVTAKDVILAIIGKLGVKGGTGKVVEFFGPGVRSLSMEGRATICN 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 300 MAPEYGATCGIFPIDDETINYLRLTNRDEDHlkLIEDYAKHQGLWRHEGDE-AHYTDTLELKLDDVVPSLAGPKRPQDRI 378
Cdd:pfam00330 222 MAIEYGATAGLFPPDETTFEYLRATGRPEAP--KGEAYDKAVAWKTLASDPgAEYDKVVEIDLSTIEPMVTGPTRPQDAV 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 379 TLDKAGDvigqhlkgfqdermarrdksdieeariesegptTNPDEPVDEAQFMGAAKVKFKGQEFELNDGACVIAAITSC 458
Cdd:pfam00330 300 PLSELVP---------------------------------DPFADAVKRKAAERALEYMGLGPGTPLSDGKVDIAFIGSC 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 459 TNTSNPSVILAAGLVAQkAKQLGINVKPWVKTSLAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTCIGNSGPLADEi 538
Cdd:pfam00330 347 TNSSIEDLRAAAGLLKK-AVEKGLKVAPGVKASVVPGSEVVRAYAEAEGLDKILEEAGFEWRGPGCSMCIGNSDRLPPG- 424
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 567929592 539 seaiqkhklvVSSILSGNRNFEGRIHQDVKmNFLASPPLVVAYAIAG 585
Cdd:pfam00330 425 ----------ERCVSSSNRNFEGRQGPGGR-THLASPALVAAAAIAG 460
|
|
| AcnA_IRP_Swivel |
cd01580 |
Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, ... |
691-861 |
7.29e-105 |
|
Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group also includes sequences that have been shown to act as an iron-responsive element (IRE) binding protein in animals and may have the same role in other eukaryotes. This is the aconitase-like swivel domain, which is believed to undergo swivelling conformational change in the enzyme mechanism.
Pssm-ID: 238812 [Multi-domain] Cd Length: 171 Bit Score: 321.92 E-value: 7.29e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 691 KLGDSVTTDHISPAGAIKAEAPAGIYLQEKGVEKAQFNSYGSRRGNHEVMMRGTFANVRLKNLLAPGTEGGVTRTQPDDK 770
Cdd:cd01580 1 LLGDSVTTDHISPAGSIAKDSPAGKYLAERGVKPRDFNSYGSRRGNDEVMMRGTFANIRLRNKLVPGTEGGTTHHPPTGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 771 LASIYDAAMEYEKSNTPLIVLAGKEYGTGSSRDWAAKGSLLLGVKAVVAQSYERIHRSNLIGMGVLPLQFKEGESHESLN 850
Cdd:cd01580 81 VMSIYDAAMRYKEEGVPLVILAGKEYGSGSSRDWAAKGPFLLGVKAVIAESFERIHRSNLVGMGILPLQFPPGENADSLG 160
|
170
....*....|.
gi 567929592 851 LTGQEQFDIEG 861
Cdd:cd01580 161 LTGEETYDIIG 171
|
|
| PRK07229 |
PRK07229 |
aconitate hydratase; Validated |
63-907 |
6.67e-83 |
|
aconitate hydratase; Validated
Pssm-ID: 235974 [Multi-domain] Cd Length: 646 Bit Score: 280.11 E-value: 6.67e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 63 WDPKAKPSAEVAFTPARVVMQDFTGVPAIVDLAAMrdameklGGDPAKInPLSPAElvIDHS-VQVDgygddgafdlnak 141
Cdd:PRK07229 15 VEGELEPGEEIAIRIDQTLTQDATGTMAYLQFEAM-------GLDRVKT-ELSVQY--VDHNlLQAD------------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 142 leyERNKERYEFLrwgQTAFDNLKVV--PPATGIVHQVNLEFLARvvfndseNGKsiaypdTLVGTDSHTT------MIn 213
Cdd:PRK07229 72 ---FENADDHRFL---QSVAAKYGIYfsKPGNGICHQVHLERFAF-------PGK------TLLGSDSHTPtagglgML- 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 214 glgvlgwgvgGI-----EAEAAMLGQPISLLIPQVVGFKLNGRLPEGTTATDLVLtvtEMLRNHGV---VGKFVEFYGDG 285
Cdd:PRK07229 132 ----------AIgagglDVALAMAGGPYYLKMPKVVGVKLTGKLPPWVSAKDVIL---ELLRRLTVkggVGKIIEYFGPG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 286 LADLPLADRATIANMAPEYGATCGIFPIDDETINYLRLTNRDEDHLKLIEDyakhqglwrhegDEAHYTDTLELKLDDVV 365
Cdd:PRK07229 199 VATLSVPERATITNMGAELGATTSIFPSDERTREFLKAQGREDDWVELLAD------------PDAEYDEVIEIDLSELE 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 366 PSLAGPKRPqdritlDKAGDVigqhlkgfqdermarrdkSDIEEariesegpttnpdEPVDEaqfmgaakvkfkgqefel 445
Cdd:PRK07229 267 PLIAGPHSP------DNVVPV------------------SEVAG-------------IKVDQ------------------ 291
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 446 ndgacviAAITSCTNTSNPSVILAAGLVaqKAKQlginVKPWVKTSLAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCT 525
Cdd:PRK07229 292 -------VLIGSCTNSSYEDLMRAASIL--KGKK----VHPKVSLVINPGSRQVLEMLARDGALADLIAAGARILENACG 358
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 526 TCIGNSG-PLADEIseaiqkhklvvsSILSGNRNFEGRI-HQDVKMnFLASPPLVVAYAIAGR-TDidvynePLaqdeng 602
Cdd:PRK07229 359 PCIGMGQaPATGNV------------SLRTFNRNFPGRSgTKDAQV-YLASPETAAASALTGViTD------PR------ 413
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 603 nDIYLKNI-WPSVSEVSELvqkTVTREMFEKSYAnvyEGDsrwqKIQIPDGKlydwddgstYIKKAPFFEGMsveppgvP 681
Cdd:PRK07229 414 -TLALENGeYPKLEEPEGF---AVDDAGIIAPAE---DGS----DVEVVRGP---------NIKPLPLLEPL-------P 466
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 682 TIEGARCLAKLGDSVTTDHISPAGaikaeapagiylqekgvekAQFNSYgsrRGNHEVMMRGTFanvrlknllapgtegg 761
Cdd:PRK07229 467 DLLEGKVLLKVGDNITTDHIMPAG-------------------AKWLPY---RSNIPNISEFVF---------------- 508
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 762 vTRTQPDdklasIYDAAMEYEKSntplIVLAGKEYGTGSSRDWAAKGSLLLGVKAVVAQSYERIHRSNLIGMGVLPLQFK 841
Cdd:PRK07229 509 -EGVDNT-----FPERAKEQGGG----IVVGGENYGQGSSREHAALAPRYLGVKAVLAKSFARIHKANLINFGILPLTFA 578
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 567929592 842 EGESHESLNLtGQEqFDIEGLYD--KTNEVSIIATNAeGKKVSFSADVridTPKEWDYYKHGGILQYV 907
Cdd:PRK07229 579 DPADYDKIEE-GDV-LEIEDLREflPGGPLTVVNVTK-DEEIEVRHTL---SERQIEILLAGGALNLI 640
|
|
| Aconitase |
cd01351 |
Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and ... |
79-585 |
1.98e-79 |
|
Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Aconitase catalytic domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course of the reaction. In eukaryotes two isozymes of aconitase are known to exist: one found in the mitochondrial matrix and the other found in the cytoplasm. Aconitase, in its active form, contains a 4Fe-4S iron-sulfur cluster; three cysteine residues have been shown to be ligands of the 4Fe-4S cluster. This is the Aconitase core domain, including structural domains 1, 2 and 3, which binds the Fe-S cluster. The aconitase family also contains the following proteins: - Iron-responsive element binding protein (IRE-BP), a cytosolic protein that binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5'UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'UTR of transferrin receptor mRNA. IRE-BP also express aconitase activity. - 3-isopropylmalate dehydratase (isopropylmalate isomerase), the enzyme that catalyzes the second step in the biosynthesis of leucine. - Homoaconitase (homoaconitate hydratase), an enzyme that participates in the alpha-aminoadipate pathway of lysine biosynthesis and that converts cis-homoaconitate into homoisocitric acid.
Pssm-ID: 153129 [Multi-domain] Cd Length: 389 Bit Score: 262.82 E-value: 1.98e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 79 RVVMQDFTGVPAIVDLAAMrdameklgGDPAKINPLSPAELVIDHSVQvdgygddgafdlnakLEYERNKERYEFLRWgq 158
Cdd:cd01351 1 RVMLQDATGPMAMKAFEIL--------AALGKVADPSQIACVHDHAVQ---------------LEKPVNNEGHKFLSF-- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 159 tAFDNLKV--VPPATGIVHQVNLEFLARvvfndsengksiaYPDTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPI 236
Cdd:cd01351 56 -FAALQGIafYRPGVGIIHQIMVENLAL-------------PGDLLVGSDSHTTSYGGLGAISTGAGGGDVAFVMAGGPA 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 237 SLLIPQVVGFKLNGRLPEGTTATDLVLTVTEMLRNHGVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGIFPIDDE 316
Cdd:cd01351 122 WLKKPEVVGVNLTGKLSPGVTGKDVVLKLGGIVGVDGVLNRIVEFYGEGVSSLSIEDRLTICNMMAELGATTGIFPEDKT 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 317 TINYLRLTNRdEDHLKLIEDYAKHQglwrHEGDEAHYTDTLELKLDDVVPSLAGPKRPQDRITLdkagdvigqhlkgfqd 396
Cdd:cd01351 202 TLKWLEATGR-PLLKNLWLAFPEEL----LADEGAEYDQVIEIDLSELEPDISGPNRPDDAVSV---------------- 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 397 ermarrdkSDIEEARIesegpttnpdepvdeaqfmgaakvkfkgqefelndgacVIAAITSCTNtSNPSVILAAGLVAQK 476
Cdd:cd01351 261 --------SEVEGTKI--------------------------------------DQVLIGSCTN-NRYSDMLAAAKLLKG 293
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 477 AKqlginVKPWVKTSLAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTCIGNSGPLADEiseaiqkhklVVSSILSGN 556
Cdd:cd01351 294 AK-----VAPGVRLIVTPGSRMVYATLSREGYYEILVDSGARILPPGCGPCMGNGARLVAD----------GEVGVSSGN 358
|
490 500
....*....|....*....|....*....
gi 567929592 557 RNFEGRIHQDVKMNFLASPPLVVAYAIAG 585
Cdd:cd01351 359 RNFPGRLGTYERHVYLASPELAAATAIAG 387
|
|
| Aconitase_C |
pfam00694 |
Aconitase C-terminal domain; Members of this family usually also match to pfam00330. This ... |
713-843 |
7.13e-48 |
|
Aconitase C-terminal domain; Members of this family usually also match to pfam00330. This domain undergoes conformational change in the enzyme mechanism.
Pssm-ID: 459908 [Multi-domain] Cd Length: 131 Bit Score: 166.39 E-value: 7.13e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 713 AGIYLQEKGVEKAQFNSYGSRRGNHEVMMRGTFANVRLKNLLAPGTEGGVTRTQPDDKLASIYDAAMEYEKSNTPLIVLA 792
Cdd:pfam00694 1 MPVFLKLKGKTTPDFNSNVDTDLIIPKQFLGTIANIGIGNINFEGWRYGKVRYLPDGENPDFYDAAMRYKQHGAPIVVIG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 567929592 793 GKEYGTGSSRDWAAKGSLLLGVKAVVAQSYERIHRSNLIGMGVLPLQFKEG 843
Cdd:pfam00694 81 GKNFGCGSSREHAAWALRDLGIKAVIAESFARIHRNNLIKNGLLPLEFPEE 131
|
|
| LeuC |
COG0065 |
Homoaconitase/3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism] ... |
79-589 |
1.44e-46 |
|
Homoaconitase/3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism]; Homoaconitase/3-isopropylmalate dehydratase large subunit is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439835 Cd Length: 417 Bit Score: 172.52 E-value: 1.44e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 79 RVVMQDFTGVPAIvdlaamrDAMEKLGG----DPAKINplspaeLVIDHSVQVDGygddgafdlnakleyERNKERYEFL 154
Cdd:COG0065 30 LHLVHDVTSPQAF-------EGLREAGGrkvwDPDRIV------AVFDHNVPTKD---------------PKSAEQVKTL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 155 R-----WGQTAFDNLKVvppatGIVHQVNLEflarvvfndsengKSIAYP-DTLVGTDSHTTM----------INGLgvl 218
Cdd:COG0065 82 RefakeFGITFFDVGDP-----GICHVVLPE-------------QGLVLPgMTIVGGDSHTCThgafgafafgIGTT--- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 219 gwgvggiEAEAAMLGQPISLLIPQVVGFKLNGRLPEGTTATDLVLTVTEMLRNHGVVGKFVEFYGDGLADLPLADRATIA 298
Cdd:COG0065 141 -------DVAHVLATGTLWFKVPETMRIEVTGKLPPGVTAKDLILAIIGKIGADGATGKAIEFAGEAIRALSMEERMTLC 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 299 NMAPEYGATCGIFPIDDETINYLRltNRdedhlklieDYAKHQGLWRHEGdeAHYTDTLELKLDDVVPSLAGPKRPQDRI 378
Cdd:COG0065 214 NMAIEAGAKAGIIAPDETTFEYLK--GR---------PFAPWRTLKSDED--AVYDKEVEIDASDLEPQVAWPHSPDNVV 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 379 TLDKAGDVigqhlkgfqdermarrdksdieeariesegpttnpdePVDEAqFMGaakvkfkgqefelndgacviaaitSC 458
Cdd:COG0065 281 PVSELEGI-------------------------------------KIDQV-FIG------------------------SC 298
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 459 TNtsnpSVI----LAAGLVaqKAKQlginVKPWVKTSLAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTCIG-NSGP 533
Cdd:COG0065 299 TN----GRIedlrAAAEIL--KGRK----VAPGVRAIVVPGSQEVYRQAEAEGLDEIFIEAGAEWREPGCGMCLGmNMGV 368
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 567929592 534 LADEiseaiqkhKLVVSSIlsgNRNFEGRI-HQDVKmNFLASPPLVVAYAIAGR-TDI 589
Cdd:COG0065 369 LAPG--------ERCASTS---NRNFEGRMgSPGSR-TYLASPATAAASAIAGRiTDP 414
|
|
| AcnA_Bact |
cd01585 |
Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA ... |
169-585 |
2.95e-44 |
|
Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Bacterial Aconitase-like catalytic domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course of the reaction. This distinct subfamily is found only in bacteria and Archaea. Its exact characteristics are not known.
Pssm-ID: 153135 Cd Length: 380 Bit Score: 164.54 E-value: 2.95e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 169 PATGIVHQVNLEFLARvvfndseNGKsiaypdTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPISLLIPQVVGFKL 248
Cdd:cd01585 66 PGNGICHQVHLERFAV-------PGK------TLLGSDSHTPTAGGLGMLAIGAGGLDVALAMAGEPYYIPMPKVVGVRL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 249 NGRLPEGTTATDLVLtvtEMLRNHGV---VGKFVEFYGDGLADLPLADRATIANMAPEYGATCGIFPIDDETINYLRLTN 325
Cdd:cd01585 133 TGELPPWVTAKDVIL---ELLRRLTVkggVGKIFEYTGPGVATLSVPERATITNMGAELGATTSIFPSDERTREFLAAQG 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 326 RDEDHLKLIEDyakhqglwrhegDEAHYTDTLELKLDDVVPSLAGPKRPqDRItldkagdvigqhlkgfqdermarrdks 405
Cdd:cd01585 210 REDDWVELAAD------------ADAEYDEEIEIDLSELEPLIARPHSP-DNV--------------------------- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 406 dieeARIESEGPTtnpdePVDEaqfmgaakvkfkgqefelndgacviAAITSCTNTSNPSVILAAGLVAqkakqlGINVK 485
Cdd:cd01585 250 ----VPVREVAGI-----KVDQ-------------------------VAIGSCTNSSYEDLMTVAAILK------GRRVH 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 486 PWVKTSLAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTCIG-NSGPLADEIseaiqkhklvvsSILSGNRNFEGRIH 564
Cdd:cd01585 290 PHVSMVVAPGSKQVLEMLARNGALADLLAAGARILESACGPCIGmGQAPPTGGV------------SVRTFNRNFEGRSG 357
|
410 420
....*....|....*....|.
gi 567929592 565 QDVKMNFLASPPLVVAYAIAG 585
Cdd:cd01585 358 TKDDLVYLASPEVAAAAALTG 378
|
|
| IPMI |
cd01583 |
3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and ... |
79-586 |
4.00e-43 |
|
3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Aconatase-like catalytic domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-isopropylmalate. IPMI is involved in fungal and bacterial leucine biosynthesis and is also found in eukaryotes.
Pssm-ID: 153133 Cd Length: 382 Bit Score: 161.59 E-value: 4.00e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 79 RVVMQDFTGVPAIvdlAAMRDAMEKLGGDPAKINplspaeLVIDHSVQVDGYgddgafdlnakLEYERNKE-RYEFLRWG 157
Cdd:cd01583 1 LHLVHDVTSPQAF---EGLREAGREKVWDPEKIV------AVFDHNVPTPDI-----------KAAEQVKTlRKFAKEFG 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 158 QTAFDnlkvvPPATGIVHQVNLEflarvvfndsengKSIAYP-DTLVGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPI 236
Cdd:cd01583 61 INFFD-----VGRQGICHVILPE-------------KGLTLPgMTIVGGDSHTCTHGAFGAFATGIGTTDVAHVLATGKL 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 237 SLLIPQVVGFKLNGRLPEGTTATDLVLTVTEMLRNHGVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGIFPIDDE 316
Cdd:cd01583 123 WFRVPETMRVNVEGKLPPGVTAKDVILYIIGKIGVDGATYKAMEFAGEAIESLSMEERMTLCNMAIEAGAKAGIVAPDET 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 317 TINYLR-LTNRDEDHLKLIEDyakhqglwrhegdeAHYTDTLELKLDDVVPSLAGPKRPQDRITLDKAGDVigqhlkgfq 395
Cdd:cd01583 203 TFEYLKgRGKAYWKELKSDED--------------AEYDKVVEIDASELEPQVAWPHSPDNVVPVSEVEGI--------- 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 396 dermarrdksdieeariesegpttnpdePVDEAqFMGaakvkfkgqefelndgacviaaitSCTNTSNPSVILAAGLVaq 475
Cdd:cd01583 260 ----------------------------KIDQV-FIG------------------------SCTNGRLEDLRAAAEIL-- 284
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 476 KAKQlginVKPWVKTSLAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTCIG-NSGPLADeiseaiqkHKLVVSsilS 554
Cdd:cd01583 285 KGRK----VADGVRLIVVPASQRVYKQAEKEGLIEIFIEAGAEVRPPGCGACLGgHMGVLAP--------GERCVS---T 349
|
490 500 510
....*....|....*....|....*....|..
gi 567929592 555 GNRNFEGRIHQDVKMNFLASPPLVVAYAIAGR 586
Cdd:cd01583 350 SNRNFKGRMGSPGARIYLASPATAAASAITGE 381
|
|
| AcnA_Mitochondrial |
cd01584 |
Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA ... |
79-587 |
2.10e-39 |
|
Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Mitochondrial aconitase A catalytic domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediary product during the course of the reaction. In eukaryotes two isozymes of aconitase are known to exist: one found in the mitochondrial matrix and the other found in the cytoplasm. This is the mitochondrial form. The mitochondrial product is coded by a nuclear gene. Most members of this subfamily are mitochondrial but there are some bacterial members.
Pssm-ID: 153134 Cd Length: 412 Bit Score: 151.44 E-value: 2.10e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 79 RVVMQDFTGVPAIvdLAAMRDAMEKlggdpakinPLSPAELVIDHSVQVDgygDDGAFDLnaKLEYERNKERYEFLRwGQ 158
Cdd:cd01584 1 RVAMQDATAQMAL--LQFMSSGLPK---------VAVPSTIHCDHLIEAQ---VGGEKDL--KRAKDINKEVYDFLA-SA 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 159 TAFDNLKVVPPATGIVHQVNLEflarvvfndsengkSIAYPDTL-VGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPIS 237
Cdd:cd01584 64 GAKYGIGFWKPGSGIIHQIVLE--------------NYAFPGLLmIGTDSHTPNAGGLGGIAIGVGGADAVDVMAGIPWE 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 238 LLIPQVVGFKLNGRLPEGTTATDLVLTVTEMLRNHGVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGIFPIDDET 317
Cdd:cd01584 130 LKCPKVIGVKLTGKLSGWTSPKDVILKVAGILTVKGGTGAIVEYFGPGVDSLSCTGMGTICNMGAEIGATTSVFPYNERM 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 318 INYLRLTNRDEdhlklIEDYAKHQGLWRHEGDE-AHYTDTLELKLDDVVPSLAGPKRPQDRITLDKAGDVigqhlkgfqd 396
Cdd:cd01584 210 KKYLKATGRAE-----IADLADEFKDDLLVADEgAEYDQLIEINLSELEPHINGPFTPDLATPVSKFKEV---------- 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 397 ermarrdksdieeariesegpttnpdepvdeaqfmgaakVKFKGQEFELNDGacviaAITSCTNTSNPSVILAAGlVAQK 476
Cdd:cd01584 275 ---------------------------------------AEKNGWPLDLRVG-----LIGSCTNSSYEDMGRAAS-IAKQ 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 477 AKQLGINVKpwVKTSLAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTCIGnsgpladEISEAIQKHKLVVSSILSGN 556
Cdd:cd01584 310 ALAHGLKCK--SIFTITPGSEQIRATIERDGLLQTFRDAGGIVLANACGPCIG-------QWDRKDIKKGEKNTIVTSYN 380
|
490 500 510
....*....|....*....|....*....|..
gi 567929592 557 RNFEGRIHQDVK-MNFLASPPLVVAYAIAGRT 587
Cdd:cd01584 381 RNFTGRNDANPAtHAFVASPEIVTAMAIAGTL 412
|
|
| PRK00402 |
PRK00402 |
3-isopropylmalate dehydratase large subunit; Reviewed |
80-588 |
3.88e-32 |
|
3-isopropylmalate dehydratase large subunit; Reviewed
Pssm-ID: 234748 Cd Length: 418 Bit Score: 130.30 E-value: 3.88e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 80 VVMQDFTGVPAIvdlaamrDAMEKLGG----DPAKInplspaELVIDHSVQvdgygddgAFDLNAKleyERNKERYEFLR 155
Cdd:PRK00402 31 VMAHDITGPLAI-------KEFEKIGGdkvfDPSKI------VIVFDHFVP--------AKDIKSA---EQQKILREFAK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 156 wgQTAFDNLKVVppATGIVHQVNLEflarvvfndsengKSIAYP-DTLVGTDSHTT----------------Minglgvl 218
Cdd:PRK00402 87 --EQGIPNFFDV--GEGICHQVLPE-------------KGLVRPgDVVVGADSHTCtygalgafatgmgstdM------- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 219 gwgvggieAEAAMLGQpISLLIPQVVGFKLNGRLPEGTTATDLVLTVTEMLRNHGVVGKFVEFYGDGLADLPLADRATIA 298
Cdd:PRK00402 143 --------AAAMATGK-TWFKVPETIKVVLEGKLPPGVTAKDVILHIIGDIGVDGATYKALEFTGETIEALSMDERMTLA 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 299 NMAPEYGATCGIFPIDDETINYLR-LTNRDEDHLKLIEDyakhqglwrhegdeAHYTDTLELKLDDVVPSLAGPKRPQDR 377
Cdd:PRK00402 214 NMAIEAGAKAGIFAPDEKTLEYLKeRAGRDYKPWKSDED--------------AEYEEVYEIDLSKLEPQVAAPHLPDNV 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 378 ITLDKAGDVigqhlkgfqdermarrdksdieeariesegpttnpdePVDEAqFMGaakvkfkgqefelndgacviaaitS 457
Cdd:PRK00402 280 KPVSEVEGT-------------------------------------KVDQV-FIG------------------------S 297
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 458 CTNtsnpsvilaaG------LVAQKAKqlGINVKPWVKTSLAPGSQvvTDYLE--KAGLMDDLESLGFnLVGY-GCTTCI 528
Cdd:PRK00402 298 CTN----------GrledlrIAAEILK--GRKVAPGVRLIVIPASQ--KIYLQalKEGLIEIFVDAGA-VVSTpTCGPCL 362
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 567929592 529 GNS-GPLAD-EIseaiqkhklVVSsilSGNRNFEGRI-HQDVKMnFLASPPLVVAYAIAGR-TD 588
Cdd:PRK00402 363 GGHmGVLAPgEV---------CLS---TTNRNFKGRMgSPESEV-YLASPAVAAASAVTGKiTD 413
|
|
| Homoaconitase |
cd01582 |
Homoaconitase and other uncharacterized proteins of the Aconitase family; Homoaconitase ... |
168-586 |
6.70e-22 |
|
Homoaconitase and other uncharacterized proteins of the Aconitase family; Homoaconitase catalytic domain. Homoaconitase and other uncharacterized proteins of the Aconitase family. Homoaconitase is part of an unusual lysine biosynthesis pathway found only in filamentous fungi, in which lysine is synthesized via the alpha-aminoadipate pathway. In this pathway, homoaconitase catalyzes the conversion of cis-homoaconitic acid into homoisocitric acid. The reaction mechanism is believed to be similar to that of other aconitases.
Pssm-ID: 153132 [Multi-domain] Cd Length: 363 Bit Score: 98.46 E-value: 6.70e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 168 PPATGIVHQVNLEflarvvfndsengKSIAYPDTL-VGTDSHTTMINGLGVLGWGVGGIEAEAAMLGQPISLLIPQVVGF 246
Cdd:cd01582 64 PAGRGIGHQIMIE-------------EGYAFPGTLaVASDSHSNMYGGVGCLGTPIVRTDAAAIWATGQTWWQIPPVAKV 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 247 KLNGRLPEGTTATDLVLTVTEMLRNHGVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGIFPIDdetinylrltnr 326
Cdd:cd01582 131 ELKGQLPKGVTGKDVIVALCGLFNKDQVLNHAIEFTGSGLNSLSVDTRLTIANMTTEWGALSGLFPTD------------ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 327 dedhlkliedyAKHqglwrhegdeahytdtLELKLDDVVPSLAGPKrpqdritldkagdvigqhlkgfqdermarrdksd 406
Cdd:cd01582 199 -----------AKH----------------LILDLSTLSPYVSGPN---------------------------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 407 ieeariesegpttnpdepvdeaqfmgAAKVKFKGQEFELNDGACVIAAITSCTNTSNPSVILAAGLVAQKAKQLGIN-VK 485
Cdd:cd01582 218 --------------------------SVKVSTPLKELEAQNIKINKAYLVSCTNSRASDIAAAADVVKGKKEKNGKIpVA 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 486 PWVKTSLAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTCIG-NSGPLAD-EIseaiqkhklvvsSILSGNRNFEGRI 563
Cdd:cd01582 272 PGVEFYVAAASSEVQAAAEKNGDWQTLLEAGATPLPAGCGPCIGlGQGLLEPgEV------------GISATNRNFKGRM 339
|
410 420
....*....|....*....|...
gi 567929592 564 HQDVKMNFLASPPLVVAYAIAGR 586
Cdd:cd01582 340 GSTEALAYLASPAVVAASAISGK 362
|
|
| PRK12466 |
PRK12466 |
3-isopropylmalate dehydratase large subunit; |
79-589 |
1.11e-20 |
|
3-isopropylmalate dehydratase large subunit;
Pssm-ID: 183543 Cd Length: 471 Bit Score: 96.13 E-value: 1.11e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 79 RVVMQDFTGVPAIVDLAAmrdameklggdpAKINPLSPAE--LVIDHSVQVDGYGDDGAFDLNAKL---EYERNKERYef 153
Cdd:PRK12466 30 RHLLNEYTSPQAFSGLRA------------RGRTVRRPDLtlAVVDHVVPTRPGRDRGITDPGGALqvdYLRENCADF-- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 154 lrwGQTAFDnlkVVPPATGIVHQVNLEflarvvfndsengKSIAYPD-TLVGTDSHTTMINGLGVLGWGVGGIEAEAAML 232
Cdd:PRK12466 96 ---GIRLFD---VDDPRQGIVHVVAPE-------------LGLTLPGmVIVCGDSHTTTYGALGALAFGIGTSEVEHVLA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 233 GQPISLLIPQVVGFKLNGRLPEGTTATDLVLTVTEMLRNHGVVGKFVEFYGDGLADLPLADRATIANMAPEYGATCGIFP 312
Cdd:PRK12466 157 TQTLVYRKPKTMRVRVDGELPPGVTAKDLILALIARIGADGATGYAIEFAGEAIRALSMEGRMTLCNMAVEAGARGGLIA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 313 IDDETINYLRLTNRDEDHlkliEDYAKHQGLWR--HEGDEAHYTDTLELK-------------------LDDVVPSLAGP 371
Cdd:PRK12466 237 PDETTFDYLRGRPRAPKG----ALWDAALAYWRtlRSDADAVFDREVEIDaadiapqvtwgtspdqavpITGRVPDPAAE 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 372 KRPQDRITLDKAGDVI----GQHLKGFqdermarrdksdieeariesegpttnpdePVDEAqFMGaakvkfkgqefelnd 447
Cdd:PRK12466 313 ADPARRAAMERALDYMgltpGTPLAGI-----------------------------PIDRV-FIG--------------- 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 448 gacviaaitSCTNTSNPSVILAAGLVAqkakqlGINVKPWVKTSLAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTC 527
Cdd:PRK12466 348 ---------SCTNGRIEDLRAAAAVLR------GRKVAPGVRAMVVPGSGAVRRQAEAEGLARIFIAAGFEWREPGCSMC 412
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 567929592 528 IGnsgpLADEISEAIQKhklVVSsilSGNRNFEGRIHQDVKMNfLASPPLVVAYAIAGR-TDI 589
Cdd:PRK12466 413 LA----MNDDVLAPGER---CAS---TTNRNFEGRQGPGARTH-LMSPAMVAAAAVAGHiTDV 464
|
|
| Aconitase_swivel |
cd00404 |
Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible ... |
786-851 |
1.60e-20 |
|
Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme mechanism. The aconitase family contains the following proteins: - Iron-responsive element binding protein (IRE-BP). IRE-BP is a cytosolic protein that binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5'UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'UTR of transferrin receptor mRNA. IRE-BP also express aconitase activity. - 3-isopropylmalate dehydratase (isopropylmalate isomerase), the enzyme that catalyzes the second step in the biosynthesis of leucine. - Homoaconitase (homoaconitate hydratase), an enzyme that participates in the alpha-aminoadipate pathway of lysine biosynthesis and that converts cis-homoaconitate into homoisocitric acid.
Pssm-ID: 238236 [Multi-domain] Cd Length: 88 Bit Score: 86.75 E-value: 1.60e-20
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 567929592 786 TPLIVLAGKEYGTGSSRDWAAKGSLLLGVKAVVAQSYERIHRSNLIGMGVLPLQFKEGESHESLNL 851
Cdd:cd00404 15 GPGVVIGDENYGTGSSREHAALELRLLGGRAVIAKSFARIFFRNLVDQGLLPLEFADPEDYLKLHT 80
|
|
| AcnA_Bact_Swivel |
cd01579 |
Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) ... |
691-847 |
2.20e-20 |
|
Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the course of the reaction. This is the aconitase-like swivel domain, which is believed to undergo swivelling conformational change in the enzyme mechanism. This distinct subfamily is found only in bacteria and archea. Its exact characteristics are not known.
Pssm-ID: 238811 [Multi-domain] Cd Length: 121 Bit Score: 87.49 E-value: 2.20e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 691 KLGDSVTTDHISPAGAikaeapagiylqekgvekaqfnSYGSRRGNHEVMMRGTFANVrlknllapgteggvtrtqpDDK 770
Cdd:cd01579 1 KVGDNITTDHIMPAGA----------------------KVLPLRSNIPAISEFVFHRV-------------------DPT 39
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 567929592 771 LAsiydaamEYEKSNTPLIVLAGKEYGTGSSRDWAAKGSLLLGVKAVVAQSYERIHRSNLIGMGVLPLQFKEGESHE 847
Cdd:cd01579 40 FA-------ERAKAAGPGFIVGGENYGQGSSREHAALAPMYLGVRAVLAKSFARIHRANLINFGILPLTFADEDDYD 109
|
|
| PRK05478 |
PRK05478 |
3-isopropylmalate dehydratase large subunit; |
247-589 |
4.30e-19 |
|
3-isopropylmalate dehydratase large subunit;
Pssm-ID: 235490 Cd Length: 466 Bit Score: 91.33 E-value: 4.30e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 247 KLNGRLPEGTTATDLVLTVtemLRNHGV---VGKFVEFYGDGLADLPLADRATIANMAPEYGATCGIFPIDDETINYLRl 323
Cdd:PRK05478 169 EVDGKLPPGVTAKDIILAI---IGKIGTaggTGYVIEFAGEAIRALSMEGRMTICNMSIEAGARAGLVAPDETTFEYLK- 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 324 tNRdeDHLKLIEDYAKHQGLWR--HEGDEAHYTDTLELK-------------------LDDVVPSLAGPKRPQDRITLDK 382
Cdd:PRK05478 245 -GR--PFAPKGEDWDKAVAYWKtlKSDEDAVFDKVVTLDaadiepqvtwgtnpgqvisIDGKVPDPEDFADPVKRASAER 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 383 AGDVIGqhLKGfqDERMarrdkSDIeeariesegpttnpdePVDEAqFMGaakvkfkgqefelndgacviaaitSCTNts 462
Cdd:PRK05478 322 ALAYMG--LKP--GTPI-----TDI----------------KIDKV-FIG------------------------SCTN-- 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 463 npSVI----LAAGLVaqKAKQLGINVKPWVktslAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTCIG-NsgplADE 537
Cdd:PRK05478 350 --SRIedlrAAAAVV--KGRKVAPGVRALV----VPGSGLVKAQAEAEGLDKIFIEAGFEWREPGCSMCLAmN----PDK 417
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 567929592 538 ISEaiqkHKLVVSsilSGNRNFEGR------IHqdvkmnfLASPPLVVAYAIAGR-TDI 589
Cdd:PRK05478 418 LPP----GERCAS---TSNRNFEGRqgkggrTH-------LVSPAMAAAAAITGHfVDV 462
|
|
| IPMI_Swivel |
cd01577 |
Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized ... |
789-855 |
2.54e-11 |
|
Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-isopropylmalate. IPMI is involved in fungal and bacterial leucine biosynthesis and is also found in eukaryotes. This is the aconitase-like swivel domain, which is believed to undergo swivelling conformational change in the enzyme mechanism.
Pssm-ID: 238809 [Multi-domain] Cd Length: 91 Bit Score: 60.68 E-value: 2.54e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 789 IVLAGKEYGTGSSR---DWAAKGsllLGVKAVVAQSYERIHRSNLIGMGVLPLQFKEGESHESLNLTGQE 855
Cdd:cd01577 20 IIVAGKNFGCGSSRehaPWALKD---AGIRAVIAESFARIFFRNAINNGLLPVTLADEDVEEVEAKPGDE 86
|
|
| AcnA_Mitochon_Swivel |
cd01578 |
Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and ... |
776-864 |
1.75e-10 |
|
Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme mechanism. In eukaryotes two isozymes of aconitase are known to exist: one found in the mitochondrial matrix and the other found in the cytoplasm. This is the mitochondrial form. The mitochondrial product is coded by a nuclear gene. Most members of this subfamily are mitochondrial but there are some bacterial members.
Pssm-ID: 238810 [Multi-domain] Cd Length: 149 Bit Score: 60.17 E-value: 1.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 776 DAAMEYEKSNTPLIVLAGKEYGTGSSRDWAAKGSLLLGVKAVVAQSYERIHRSNLIGMGVLPLQFKEGESHESLNLTgqE 855
Cdd:cd01578 59 DTARDYKAHGIKWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYDKIHPD--D 136
|
....*....
gi 567929592 856 QFDIEGLYD 864
Cdd:cd01578 137 KVDILGLTD 145
|
|
| PRK14023 |
PRK14023 |
homoaconitate hydratase small subunit; Provisional |
789-906 |
2.17e-10 |
|
homoaconitate hydratase small subunit; Provisional
Pssm-ID: 184460 [Multi-domain] Cd Length: 166 Bit Score: 60.20 E-value: 2.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 789 IVLAGKEYGTGSSRDWAAKGSLLLGVKAVVAQSYERIHRSNLIGMGVLPlqFKEGESHESLNlTGQE-QFDIeglydktn 867
Cdd:PRK14023 52 ILVAGRNFGLGSSREYAPEALKMLGIGAIIAKSYARIFYRNLVNLGIPP--FESEEVVDALE-DGDEvELDL-------- 120
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 567929592 868 EVSIIATNAEgkkvsfsaDVRIDTPKEW--DYYKHGGILQY 906
Cdd:PRK14023 121 ETGVLTRGGE--------TFQLRPPPEFllEALKEGSILEY 153
|
|
| LeuD |
COG0066 |
3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; ... |
789-883 |
1.38e-09 |
|
3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; 3-isopropylmalate dehydratase small subunit is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439836 [Multi-domain] Cd Length: 195 Bit Score: 58.64 E-value: 1.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 789 IVLAGKEYGTGSSRD---WAAKGsllLGVKAVVAQSYERIHRSNLIGMGVLPLQFKEGESHESLNLTGQEQFDieglydk 865
Cdd:COG0066 67 ILVAGRNFGCGSSREhapWALKD---YGFRAVIAPSFADIFYRNAINNGLLPIELPEEAVDALFAAIEANPGD------- 136
|
90 100
....*....|....*....|...
gi 567929592 866 tnEVSI-----IATNAEGKKVSF 883
Cdd:COG0066 137 --ELTVdleagTVTNGTGETYPF 157
|
|
| PRK11413 |
PRK11413 |
putative hydratase; Provisional |
167-381 |
2.35e-08 |
|
putative hydratase; Provisional
Pssm-ID: 183125 [Multi-domain] Cd Length: 751 Bit Score: 58.10 E-value: 2.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 167 VPPATGIVHQVNLEFLArvvfndsENGKSIaypdtlVGTDSHT------TMinglgvlgwgvgGI-----EAEAAMLGQP 235
Cdd:PRK11413 123 VPPHIAVIHQYMREMMA-------GGGKMI------LGSDSHTrygalgTM------------AVgegggELVKQLLNDT 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 236 ISLLIPQVVGFKLNGRLPEGTTATDLVLTVT-EMLRNHGVVGKFVEFYGDGLADLPLADRATIANMAPEygATC--GIFP 312
Cdd:PRK11413 178 YDIDYPGVVAVYLTGKPAPGVGPQDVALAIIgAVFKNGYVKNKVMEFVGPGVSALSTDFRNGVDVMTTE--TTClsSIWQ 255
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 567929592 313 IDDETINYLRLTNRDEDHLKLiedyakhqglwrHEGDEAHYTDTLELKLDDVVPSLAGPKRPQDRITLD 381
Cdd:PRK11413 256 TDEEVHNWLALHGRGQDYCEL------------NPQPMAYYDGCISVDLSAIKPMIALPFHPSNVYEID 312
|
|
| LEUD_arch |
TIGR02087 |
3-isopropylmalate dehydratase, small subunit; This subfamily is most closely related to the ... |
764-910 |
1.49e-07 |
|
3-isopropylmalate dehydratase, small subunit; This subfamily is most closely related to the 3-isopropylmalate dehydratase, small subunits which form TIGR00171. This subfamily includes the members of TIGR02084 which are gene clustered with other genes of leucine biosynthesis. The rest of the subfamily includes mainly archaeal species which exhibit two hits to this model. In these cases it is possible that one or the other of the hits does not have a 3-isopropylmalate dehydratase activity but rather one of the other related aconitase-like activities.
Pssm-ID: 273961 [Multi-domain] Cd Length: 154 Bit Score: 51.65 E-value: 1.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 764 RTQPDDKLASIydaAME------YEKSNTPLIVLAGKEYGTGSSRDWAAKGSLLLGVKAVVAQSYERIHRSNLIGMGvLP 837
Cdd:TIGR02087 22 RTTDPDELASH---AMEgidpefAKKVRPGDVIVAGKNFGCGSSREQAALALKAAGIAAVIAESFARIFYRNAINIG-LP 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 567929592 838 LqfkegesheslnLTGQEQFDIEGlydktNEVSIIATNAEgKKVSFSADVRIDTPKEW--DYYKHGGILQYVLRN 910
Cdd:TIGR02087 98 L------------IEAKTEGIKDG-----DEVTVDLETGE-IRVNGNEEYKGEPLPDFllEILREGGLLEYLKKR 154
|
|
| leuD |
PRK00439 |
3-isopropylmalate dehydratase small subunit; Reviewed |
789-838 |
3.41e-07 |
|
3-isopropylmalate dehydratase small subunit; Reviewed
Pssm-ID: 234762 [Multi-domain] Cd Length: 163 Bit Score: 50.98 E-value: 3.41e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 567929592 789 IVLAGKEYGTGSSRD---WAAKGSlllGVKAVVAQSYERIHRSNLIGMGvLPL 838
Cdd:PRK00439 51 IIVAGKNFGCGSSREhapIALKAA---GVSAVIAKSFARIFYRNAINIG-LPV 99
|
|
| AcnB |
cd01581 |
Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA ... |
169-587 |
5.22e-06 |
|
Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Aconitase B catalytic domain. Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle. Aconitase has an active (4FE-4S) and an inactive (3FE-4S) form. The active cluster is part of the catalytic site that interconverts citrate, cis-aconitase and isocitrate. The domain architecture of aconitase B is different from other aconitases in that the catalytic domain is normally found at C-terminus for other aconitases, but it is at N-terminus for B family. It also has a HEAT domain before domain 4 which plays a role in protein-protein interaction. This alignment is the core domain including domains 1,2 and 3.
Pssm-ID: 153131 Cd Length: 436 Bit Score: 49.80 E-value: 5.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 169 PATGIVHQVnleflarvvFNDsengksIAYPDTL-VGTDSHTTMinGLGVLGWGVGGIEAEAAMLGQpISLLIPQVVGFK 247
Cdd:cd01581 91 PGDGVIHSW---------LNR------MLLPDTVgTGGDSHTRF--PIGISFPAGSGLVAFAAATGV-MPLDMPESVLVR 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 248 LNGRLPEGTTATDLV------------LTVTEMLRNHGVVGKFVEFygDGLADLpLADRA-TIANMAPEYGATCGIFPID 314
Cdd:cd01581 153 FKGKMQPGITLRDLVnaipyyaiqqglLTVEKKGKKNVFNGRILEI--EGLPDL-KVEQAfELTDASAERSAAACTVRLD 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 315 DET-INYLR---------LTNRDEDH---LKLIEDYAKhqglWRHEGD------EAHYTDTLELKLDDVV-PSLAGPKRP 374
Cdd:cd01581 230 KEPvIEYLEsnvvlmkimIANGYDDArtlLRRIIAMEE----WLANPPllepdaDAEYAAVIEIDLDDIKePILACPNDP 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 375 QDRITLDKAGdvigqhlkgfqdermarrdksdieeariesegpttnpDEPVDEAqFMGaakvkfkgqefelndgacviaa 454
Cdd:cd01581 306 DDVKLLSEVA-------------------------------------GKKIDEV-FIG---------------------- 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929592 455 itSCtnTSNPSVILAAGLVAQKAKQlgINVKPWVktslAPGSQVVTDYLEKAGLMDDLESLGFNLVGYGCTTCIGNSGPL 534
Cdd:cd01581 326 --SC--MTNIGHFRAAAKILRGKEF--KPTRLWV----APPTRMDWAILQEEGYYSIFGDAGARTEMPGCSLCMGNQARV 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 567929592 535 ADEISeaiqkhklVVSsilSGNRNFEGRIHQDVKMnFLASPPLVVAYAIAGRT 587
Cdd:cd01581 396 ADGAT--------VFS---TSTRNFDNRVGKGAEV-YLGSAELAAVCALLGRI 436
|
|
| leuD |
PRK01641 |
3-isopropylmalate dehydratase small subunit; |
789-852 |
3.65e-05 |
|
3-isopropylmalate dehydratase small subunit;
Pssm-ID: 179314 [Multi-domain] Cd Length: 200 Bit Score: 45.50 E-value: 3.65e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 567929592 789 IVLAGKEYGTGSSRD---WAakgslLL--GVKAVVAQSYERIHRSNLIGMGVLPLQ---------FKEGESHESLNLT 852
Cdd:PRK01641 70 ILLAGDNFGCGSSREhapWA-----LAdyGFRAVIAPSFADIFYNNCFKNGLLPIVlpeedvdelFKLVEANPGAELT 142
|
|
| PLN00072 |
PLN00072 |
3-isopropylmalate isomerase/dehydratase small subunit; Provisional |
789-839 |
2.36e-04 |
|
3-isopropylmalate isomerase/dehydratase small subunit; Provisional
Pssm-ID: 177701 [Multi-domain] Cd Length: 246 Bit Score: 43.69 E-value: 2.36e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 567929592 789 IVLAGKEYGTGSSRDWAAKGSLLLGVKAVVAQSYERIHRSNLIGMG-VLPLQ 839
Cdd:PLN00072 132 IIIGGENFGCGSSREHAPVALGAAGAKAVVAESYARIFFRNSVATGeVYPLE 183
|
|
| |
